1.
Fudan University Journal of Medical Sciences
; (6): 115-118, 2024.
Article
in Chinese
| WPRIM
| ID: wpr-1019588
ABSTRACT
HHIP gene encoded human hedgehog-interacting protein,locating on chromosome 4q31.21-31.3.As an endogenous antagonist of Hedgehog(Hh)signaling pathway,HHIP inhibits the activation of Hh signaling pathway.In human cancers,the Hh signaling pathway has always been abnormally activated,and HHIP expression is generally down-regulated in most types of tumor tissues.The expression level of HHIP is positively correlated with overall survival of tumor patients,which is expected to be used as an independent prognostic marker.This review focused on the progress of HHIP research regarding its biological function,mechanism,and clinical value in tumor.