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1.
Article in Chinese | WPRIM | ID: wpr-1014626

ABSTRACT

Cholestatic liver disease is a common disease that causes bile flow dysfunction due to various reasons. The etiology of cholestatic liver disease is complexed, and therapeutic drugs are extremely limited. To date, ursodeoxycholic acid is the only FDA-approved drug for treating primary biliary cirrhosis, whereas its efficacy is limited to early stage of the disease, therefore novel drugs are urgently needed. Nuclear receptors become therapeutic hotspot target in cholestasis since these receptors play a key role in regulating bile acid homeostasis. Peroxisome proliferator-activated receptor (PPAR) is an important nuclear receptor involved in regulating multiple mechanisms of cholestasis in vivo. It can improve intrahepatic cholestasis by inhibiting bile acid synthesis, reducing bile acid toxicity, affecting the expression of bile acid metabolic enzymes and transporters, and can play an anti-inflammatory, anti-oxidation and anti-fibrosis role. A number of studies have shown that PPAR agonists represented by fibrates alone or in combination can improve liver function indexes, inflammatory factors and fibrosis markers in patients with cholestasis. This review analyzes and summarizes the lastest advances in the molecular mechanism of PPAR as a therapeutic target for cholestasis and drug treatment in development or have been used in clinical.

2.
Article in Chinese | WPRIM | ID: wpr-614398

ABSTRACT

Objective To compare the impact of bowel preparation on postoperative complications of patients undergoing radical cystectomy(RC) with ileal conduit diversion(ICD) by meta-analysis.Methods All literature were collected from VIP,CNKI,WanFang Data,CBMdisc,Pubmed,Medline,Embase dated from inception to April 2016.Then literature were grouped into mechanical bowel preparation and nonmechanical bowel preparation,whose differences in the wound,intestinal function,infection and other complications were compared.Results Three RCTs,four cohort studies and 656 cases were taken into account.No statistical difference was observed in the wound infection,wound dehiscence,fascia dehiscence,intestinal obstruction,anastomosis fistula,intestinal fistula,urinary leakage,death of indicators between the two groups.Conclusion Preoperative mechanical bowel preparation did not reduce the occurrence of postoperative complications of the patients with RC undergoing ICD.

3.
Article in Chinese | WPRIM | ID: wpr-501551

ABSTRACT

Objective To make specific clear labels which can lead us to easily distinguish tube category,function,the drainage of fluid properties and so on,and to improve the safety of patients tube management.Methods Using BarTender software to create labels format,and printing out all kinds of the labels by bar code printer,pasting around at suitable locations.Results Labels designed and printed by Bar-Tender software could be more efficient,accurate and clear to mark patients’drain,which avoided illegible writing.Conclusion Labels de-signed and printed by BarTender software can help doctors and nurses identifying the tube and handover management.

4.
Article in Chinese | WPRIM | ID: wpr-604846

ABSTRACT

Objective To investigate the correlation between hemorrhage in transurethral resection of prostate ( TURP) and cystospasm and psychonosema of the patients with hyperplasia of prostate. Methods All clinic data of 322 patients with hyperplasia of prostate who have had TURP from 2009 to 2013 were reviewed. These patients were divided into four groups according to the volume of hemorrhage( H):H<400 mL, 400≤H<600 mL, 600≤H<800 mL, H≥800 mL. The quantity of cystospasm and psychonosema was measured by three catego-ries:no symptom, light symptom without treatment, severe symptom with treatment. The differences of the four groups were compared through statistical methods. Results The incidence rates of cystopasm and severity degree of psychonosema were increased with the raise of hemorrhage . Conclusion There is a positive correlation between the incidence rates of cystopasm and psychonosema and the volume of hem-orrhage in the patients with hyperplasia of prostate who have had TURP.

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