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Article in Chinese | WPRIM | ID: wpr-936115


OBJECTIVE@#To evaluate the clinical effect of root canal obturation therapy using cold flowable gutta-percha on young permanent teeth after apexification.@*METHODS@#Ninety cases of young permanent teeth with pulp necrosis or periapical periodontitis treated by apexification were randomly divided into two groups. The cases in each group were divided into single root canal and multiple root canal according to the number of the root canal, and divided into classifications Ⅰ, and Ⅱ/Ⅲ/Ⅳ according to Frank's classification of root development after apexification. Cold flowable gutta-percha and warm gutta-percha obturation techniques were used for root canal obturation of the two groups. The operation time was recorded, and the patients' therapy pain degree was evaluated by visual analog scale (VAS) immediately after operation. Periapical X-ray was performed after operation to evaluate the effect of the root canal filling. The total length of the root was divided into equal three parts on the X-ray film, and three-dimensional tightness of the apical, middle, and coronal region of the root canals were statistically analyzed respectively. Clinical examinations and X-ray examination were performed 6 and 12 months after the operation to evaluate the treatment success rate.@*RESULTS@#The operation time of cold flowable gutta-percha group was significantly lower than that of the control group, which were 51 s and 74 s (P < 0.05); The percentages of pain and discomfort in the two groups were 26.67% and 40.00%, respectively. There were two cases of underfilling and no overfilling in both groups. The percentages of proper filling and tight three-dimensional obturation in the experimental and control groups were 71.11% and 60.00% respectively; and the percentages of tight three-dimensional obturation in the apical third areas were 86.67% and 66.67%, the difference was significant (P < 0.05). There was no significant difference in the three-dimensional tightness between the two groups in the middle and coronal third areas. The percentages of tight three-dimensional obturation in classification Ⅰ groups were 86.67%, 83.33%, 93.33% and 76.67%, 90.00%, 96.67% in experimental and control group, respectively; The percentages of classification Ⅱ/Ⅲ/Ⅳ groups were 86.67%, 86.67%, 100.00% and 46.67%, 86.67%, 100.00%, respectively, and the difference was significant (P < 0.05). There were no apical lesions that occurred in either group during the one-year review period.@*CONCLUSION@#The application of cold flowable gutta-percha on young permanent teeth root canal obturation after apexification can achieve good obturation effect. The root obturation effect in the apical third area is significantly better than that of warm gutta-percha obturation techniques. Cold flowable gutta-percha can shorten the clinical treatment time and ameliorate the patients' therapy comfort.

Apexification , Dental Pulp Cavity , Gutta-Percha , Humans , Radiography , Root Canal Filling Materials , Root Canal Obturation , Root Canal Preparation
Article in Chinese | WPRIM | ID: wpr-880113


METHODS@#To establish the acquired aplastic anemia mouse model through the X-ray irradiation in combination with lymphocytes injection. AA Group: the purified Pan T lymphocytes from the spleen of C57BL/6J mice were enriched and injected to the mice through tail vein(5×10@*RESULTS@#Compared with 4, 5 Gy irradiated mice in AA groups, the survival time of 3 Gy irradiated AA groups was significantly prolonged. 3, 4 and 5 Gy X-ray irradiation combined with Pan T lymphocyte injection could successfully induced severe reduction of red blood cells, blood neutrophils, and platelets, severe reduction of bone marrow nucleated cells, severe bone marrow hematopoietic failure, and the significant expansion of T lymphocytes ratio in the bone marrow. CD4@*CONCLUSION@#3, 4 and 5 Gy X-ray irradiation combined with 5×10

Anemia, Aplastic , Animals , Bone Marrow , Bone Marrow Cells , CD8-Positive T-Lymphocytes , Humans , Mice , Mice, Inbred C57BL
Chinese Journal of Stomatology ; (12): 157-161, 2011.
Article in Chinese | WPRIM | ID: wpr-339784


<p><b>OBJECTIVE</b>To investigate the role of pulp in the root resorption of primary teeth without permanent tooth germs.</p><p><b>METHODS</b>The animal model without permanent tooth germs was established by surgery in Beagle dog. The root resorption was observed by taking periapical radiographs periodically. The samples of mandibular bone and pulp at different resorption stages were collected. The distribution of odontoclasts and the activating factor was analyzed by histological staining and semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR). The role of pulp in the root resorption of primary teeth was tested by early pulpectomy.</p><p><b>RESULTS</b>In the root resorption of primary molars without permanent teeth germs, a large number of odontoclasts were present on the pulpal surface of the root canal. Semi-quantification RT-PCR showed that the ratios of the expression of receptor activator of NF-κB ligand (RANKL) mRNA and β-actin in the pulp of permanent teeth and primary teeth without permanent teeth germ during different periods of root resorption are 0.1314, 0.1901, 0.2111 and 0.6058 (P > 0.05). The root resorption of primary teeth without permanent teeth germs in test groups was about 5 weeks later than that of control group.</p><p><b>CONCLUSIONS</b>The pulp of primary tooth played an important role in the root resorption of primary tooth without permanent tooth germ.</p>

Actins , Metabolism , Animals , Dental Pulp , Metabolism , Physiology , Dental Pulp Cavity , Metabolism , Dogs , Male , Molar , Osteoclasts , Cell Biology , RANK Ligand , Genetics , Metabolism , RNA, Messenger , Metabolism , Root Resorption , Metabolism , Tooth Germ , Tooth, Deciduous , Physiology
Article in Chinese | WPRIM | ID: wpr-561543


Objective To investigate the incidence and clinical characteristics of urinary carcinoma in the patients with aristolochic acid nephropathy(AAN)in uremia stage who received maintenance hemodialysis or renal transplantation.Methods The data of 38 AAN patients who had received renal replacement therapy and treated in the authors' service from Mar.2000 to Dec.2006 were reviewed,and the incidence and clinical pathological features of urinary carcinoma in these 38 AAN patients were summarized,in order to look for correlation between the frequency of hemodialysis and the occurrence of carcinoma.Results 15 of the 38 AAN patients received hemodialysis,and the remaining 23 patients underwent renal transplantation.During the follow-up period,seven patients who received hemodialysis were reported to have developed urinary carcinoma,the incidence was 46.7%(7/15),which was significantly higher than the incidence in patients who had undergone renal transplantation(3/23,13.0%;P0.05).Conclusion The prevalence of urinary carcinoma was much lower in the AAN patients who had undergone successful renal transplantation than in those patients who received only maintenance hemodialysis.Renal transplantation may be of a better treatment for the AAN patients in uremia stage.There was no correlation between the frequency of hemodialysis and the incidence of carcinoma.