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China Pharmacy ; (12): 1372-1376, 2020.
Article in Chinese | WPRIM | ID: wpr-821804


OBJECTIVE:To systematically e valuate the efficacy and safety of duloxetine in the improvement of pain symptoms of knee osteoarthritis (KOA),and to provide evidence-based reference for clinical treatment of KOA. METHODS :Retrieved from PubMed,Embase,Medline,Cochrane Library ,CNKI,VIP and Wanfang database ,during the establishment of the database to Sept. 2019,RCTs about duloxetine (trial group )vs. placebo (control group )in the improvement of pain symptoms of KOA were collected. After data extraction and quality evaluation using Cochrane system evaluator ’s manual 5.1.0,Meta-analysis was performed by using Stata 14.0 software for WOMAC total score ,WOMAC pain score ,WOMAC stiffness score ,WOMAC function score and BPI-S score ,as well as the incidence of adverse reaction such as dry mouth ,somnolence and nausea. RESULTS:A total of 6 RCTs were included ,involving 2 059 patients. Meta-analysis results showed that WOMAC total score [MD=-0.34,95%CI(-0.48,-0.20),P<0.05],WOMAC pain score [MD =-0.41,95%CI(-0.54,-0.29),P<0.05], WOMAC stiffness score [MD =-0.24,95% CI(-0.37,-0.12),P<0.05],WOMAC function score [MD =-0.43,95%CI (-0.55,-0.31),P<0.05],BPI-S score [MD =-0.38,95%CI(-0.48,-0.28),P<0.05] of trial group were significantly lower than those of control group ;the incidence of dry mouth [RR =3.55,95%CI(2.00,6.29),P<0.05],somnolence [RR =3.23, 95%CI(1.88,5.54),P<0.05] and nausea [RR =6.95,95%CI(2.99,16.15),P<0.05] in trial group were significantly higher than control group ,with significant difference. CONCLUSIONS :Duloxetine can relieve the pain and improve knee function in patients with KOA ,but it is necessary to pay attention to its adverse reactions.

Chinese Journal of Trauma ; (12): 64-68, 2010.
Article in Chinese | WPRIM | ID: wpr-390939


Objective To compare the clinical outcome of shape memory alloy (SMA) embra-cing fixator and reconstruction plate fixation in treatment of displaced or comminuted midshaft clavicle fractures. Methods There were 65 patients with displaced or comminuted midshaft clavicle fractures surgically treated with either a SMA embracing fixator or a reconstruction plate. The patients were divided into two groups according to fixation methods, ie, SMA embracing fixator group (30 patients at average age of 28.1 years) and reconstruction plate group (35 patients at average age of 26.1 years). All pa-tients were followed up for mean 12 months and shoulder function was evaluated using shoulder score. Results Compared with reconstruction plate group, SMA embracing fixator had shorter operation time, smaller wound incision and less loss blood (all P < 0.05). However, there was no statistical difference in aspects of hospital stay, cost, JOA shoulder score and bone union rate between two groups (all P > 0.05). Conclusion The internal fixation with SMA embracing fixator is better than reconstruction plate fixation in treatment of midshaft clavicle fractures.

Article in Chinese | WPRIM | ID: wpr-404369


BACKGROUND:The non-steroidal antiinflammatory drugs (NSAIDs) were widely used to prevent heterotopic bone formation following total hip arthroplasty (THA),however,its efficacy and safety is poorly understood.OBJECTIVE:To determine the efficacy and safety of postoperative NSAIDs therapy in patients undergoing THA using Meta analysis.METHODS:The databases of PubMed,Embase,Cochrane Library,Chinese biomedical literature,CNKI,VIP as well as bibliographies of retrieved articles were researched for randomized controlled trials comparing NSAID versus control after THA,and the data were analyzed using Review Manager 5.0.RESULTS AND CONCLUSION:A total of 13 randomized controlled trials totaling 4706 participants were included.The result of meta analysis showed that low dose aspirin did not significantly affect the incidence of heterotopic bone formation (HBF) [RR=0.99,95% CI (0.87,1.14) rather than medium to high dose NSAIDs [RR=0.44,95% CI(0.30,0.64),there was no significant difference between two group in hip pain and physical function,the incidence of HBF was 16.0% in NSAID-group and 11.1% in 7 Gy group.Apart from low dose aspirin,medium to high doses of postoperative NSAIDs produce a substantial reduction in the incidence of HBF at the cost of minor high gastrointestinal side effect.Limited evidence showed there were no significant differences between the groups for improvements in hip pain and physical function,7 Gy fraction is more effective than use of NSAID.