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1.
Organ Transplantation ; (6): 463-468, 2024.
Article in Chinese | WPRIM | ID: wpr-1016913

ABSTRACT

With persistent breakthrough and maturity of surgical procedures and postoperative immunosuppressive therapy, the survival rate of liver transplant recipients and grafts has been significantly increased. The shortage of donor liver has become the main obstacle for clinical development of liver transplantation. How to expand the source of donor liver has become an urgent issue. Groundbreaking progresses have been made in the use of common marginal donor livers in clinical liver transplantation, such as elderly donor liver, steatosis donor liver, viral hepatitis donor liver and liver from donation after cardiac death. Nevertheless, multiple restrictions still exist regarding the use of marginal donor liver. Consequently, the definition of marginal donor liver and research progress in the application of common marginal donor livers were reviewed, and the opportunities and challenges of mariginal donoor liver were illustrated, aiming to provide reference for expanding the donor pool for clinical liver transplantation and bringing benefits to more patients with end-stage liver disease.

2.
Journal of Clinical Hepatology ; (12): 2506-2512, 2023.
Article in Chinese | WPRIM | ID: wpr-998322

ABSTRACT

Since the 1970s, patients with chronic pancreatitis (CP) have benefited from total pancreatectomy with autologous islet cell transplantation (TPAIT). With the continuous development of surgical techniques and perioperative management over the past few decades, there have been improvements in islet cell function, insulin independence rate, and the survival rate of patients. This article summarizes the preoperative indications for TPAIT, the development of surgical operations, postoperative management and monitoring, and prognosis, so as to help clinicians learn more about TPAIT.

3.
Chinese Journal of Epidemiology ; (12): 581-586, 2023.
Article in Chinese | WPRIM | ID: wpr-985530

ABSTRACT

Objective: To forecast mortality, age-standardized mortality, and probability of premature mortality from diabetes, and to simulate the impact of controlling risk factors by 2030 in China. Methods: We simulated the burden of disease from diabetes in six scenarios according to the development goals of risk factors control by the WHO and Chinese government. Based on the theory of comparative risk assessment and the estimates of the burden of disease for China from the Global Burden of Disease Study 2015, we used the proportional change model to project the number of deaths, age-standardized mortality, and probability of premature mortality from diabetes under different scenarios of risk factors control in 2030. Results: If the trends in exposures to risk factors from 1990 to 2015 continued. Mortality, age-standardized mortality, and probability of premature mortality from diabetes would increase to 32.57/100 000, 17.32/100 000, and 0.84% by 2030, respectively. During that time, mortality, age-standardized mortality and probability of premature mortality for males would all be higher than for females. If the goals of controlling risk factors were all achieved, the number of deaths from diabetes in 2030 would decrease by 62.10% compared to the predicted numbers based on the historical trends in exposure to risk factors, and the probability of premature mortality would drop to 0.29%. If only the exposure to a single risk factor were achieved by 2030, high fasting plasma glucose control would have the greatest impact on diabetes, resulting in a 56.00% reduction in deaths compared to the predicted numbers based on the historical trends, followed by high BMI (4.92%), smoking (0.65%), and low physical activity (0.53%). Conclusions: Risk factors control plays an important role in reducing the number of deaths, age-standardized mortality rate, and probability of premature mortality from diabetes. We suggest taking comprehensive measures to control relevant risk factors for certain populations and regions, to achieve the goal of reducing the burden of disease from diabetes as expected.


Subject(s)
Male , Female , Humans , Risk Factors , Diabetes Mellitus/epidemiology , Mortality, Premature , Smoking , Cost of Illness , China/epidemiology , Global Burden of Disease
4.
Article in Chinese | WPRIM | ID: wpr-988753

ABSTRACT

Background Diacetyl (DC) is widely used in the food flavoring industry and excessive occupational exposure to DC can cause serious respiratory diseases. However, there is no corresponding national standard method for the determination of DC in the air of workplace. Objective To establish a method for the determination of DC in workplace air by high performance liquid chromatography using 4-nitro-o-phenylenediamine (NPDA) as precolumn derivatization. Methods DC in the air of workplace was collected by solution absorption method. This experiment used NPDA as the derivatization reagent. By adjusting acidity of solution and optimizing concentration ration of DC/NPDA, derivatization temperature, and time, a method for the determination of DC in workplace air was proposed, and its performance indexes such as linearity, detection limit, and lower limit of quantification were obtained. Sampling efficiency was evaluated by relative comparison method, and sample stability was evaluated by sample preservation test. Accuracy and precision of the method were evaluated by standard addition recovery test with blank samples, and an interference test was carried out by adding standard samples. The established method was applied to actual samples to evaluate its adaptability. Results A combination of 60 °C for 2 h was selected for derivatization because a higher derivatization reaction temperature and a longer reaction time associated with a higher derivatization efficiency. The solution was separated by SB-C18 column (250 mm×4.6 mm, 5 μm) at 30 ℃, using a mixture of methanol and water (v/v, 65%/35%) as mobile phase with an elution flow rate of 1.0 mL·min−1, and was detected with a variable wavelength detector (λmax=257 nm) by qualitative analysis based on retention time and quantitative analysis based on external standard method. In terms of the proposed method, the linear range of detection was from 5 μg·L−1 to 2000 μg·L−1, with a correlation coefficient of 0.9999, and a detection limit of 1.3 μg·L−1, the quantitative detection of the lower limit was 4.3 μg·L−1, with a sampling volume V0 of 3.0 L, the minimum detection concentration was 4.3 μg·m−3, and the minimum quantitative concentration was 14.3 μg·m−3. The recovery rate was 99.1%-100.8%, the intra-batch precision was 0.5%-3.0%, and the inter-batch precision was 1.2%-2.0%. The average sampling efficiency of this method was 94.5%, and the sample could be stored at 4 °C for at least 14 d. The coexisting components in the air of the workplace did not interfere with the determination of DC. The DC content in the air of a flavor workplace was 5.86-8.85 mg·m−3. Conclusion A determination method for DC in workplace air by high performance liquid chromatography using NPDA as precolumn derivatization after being collected by 1.0% phosphoric acid absorbent is proposed and has the advantages of simple operation, high sensitivity, and good accuracy. With no DC loss and degradation, the method may satisfy the request for DC determination in the air of workplace.

5.
Chinese Journal of Biotechnology ; (12): 2644-2655, 2023.
Article in Chinese | WPRIM | ID: wpr-981222

ABSTRACT

Nearly a quarter of the world's population is infected with Mycobacterium tuberculosis and remains long-term asymptomatic infection. Rv2626c is a latent infection-related protein regulated by DosR of M. tuberculosis. In this study, the Rv2626c protein was prokaryotically expressed and purified, and its immunobiological characteristics were analyzed using RAW264.7 cells and mice as infection models. SDS-PAGE and Western blotting analysis showed that the Rv2626c-His fusion protein was mainly expressed in soluble form and specifically reacted with the rabbit anti-H37RV polyclonal serum. In addition, we found that the Rv2626c protein bound to the surface of RAW264.7 macrophages and up-regulated the production of NO. Moreover, the Rv2626c protein significantly induced the production of pro-inflammatory cytokines IFN-γ, TNF-α, IL-6 and MCP-1, and induced strong Th1-tendency immune response. These results may help to reveal the pathogenic mechanism of M. tuberculosis and facilitate the development of new tuberculosis vaccine.


Subject(s)
Animals , Mice , Rabbits , Mycobacterium tuberculosis/genetics , Tuberculosis , Antigens, Bacterial , Cytokines , Immunity, Cellular
6.
J. forensic med ; Fa yi xue za zhi;(6): 262-270, 2023.
Article in English | WPRIM | ID: wpr-981859

ABSTRACT

OBJECTIVES@#To compare the application value of the likelihood ratio (LR) method and identity by state (IBS) method in the identification involving half sibling relationships, and to provide a reference for the setting of relevant standards for identification of half sibling relationship.@*METHODS@#(1) Based on the same genetic marker combinations, the reliability of computer simulation method was verified by comparing the distributions of cumulated identity by state score (CIBS) and combined full sibling index in actual cases with the distributions in simulated cases. (2) In different numbers of three genetic marker combinations, the simulation of full sibling, half sibling and unrelated individual pairs, each 1 million pairs, was obtained; the CIBS, as well as the corresponding types of cumulative LR parameters, were calculated. (3) The application value of LR method was compared with that of IBS method, by comparing the best system efficiency provided by LR method and IBS method when genetic markers in different amounts and of different types and accuracy were applied to distinguish the above three relational individual pairs. (4) According to the existing simulation data, the minimum number of genetic markers required to distinguish half siblings from the other two relationships using different types of genetic markers was estimated by curve fitting.@*RESULTS@#(1) After the rank sum test, under the premise that the real relationship and the genetic marker combination tested were the same, there was no significant difference between the simulation method and the results obtained in the actual case. (2) In most cases, under the same conditions, the system effectiveness obtained by LR method was greater than that by IBS method. (3) According to the existing data, the number of genetic markers required for full-half siblings and half sibling identification could be obtained by curve fitting when the system effectiveness reached 0.95 or 0.99.@*CONCLUSIONS@#When distinguishing half sibling from full sibling pairs or unrelated pairs, it is recommended to give preference to the LR method, and estimate the required number of markers according to the identification types and the population data, to ensure the identification effect.


Subject(s)
Humans , Siblings , Genetic Markers , Computer Simulation , Irritable Bowel Syndrome/genetics , Reproducibility of Results , Genotype
7.
Chinese Journal of Hematology ; (12): 484-489, 2023.
Article in Chinese | WPRIM | ID: wpr-984648

ABSTRACT

Objective: To assess the efficacy and safety of polymyxin B in neutropenic patients with hematologic disorders who had refractory gram-negative bacterial bloodstream infection. Methods: From August 2021 to July 2022, we retrospectively analyzed neutropenic patients with refractory gram-negative bacterial bloodstream infection who were treated with polymyxin B in the Department of Hematology of the First Affiliated Hospital of the Soochow University between August 2021 to July 2022. The cumulative response rate was then computed. Results: The study included 27 neutropenic patients with refractory gram-negative bacterial bloodstream infections. Polymyxin B therapy was effective in 22 of 27 patients. The median time between the onset of fever and the delivery of polymyxin B was 3 days [interquartile range (IQR) : 2-5]. The median duration of polymyxin B treatment was 7 days (IQR: 5-11). Polymyxin B therapy had a median antipyretic time of 37 h (IQR: 32-70). The incidence of acute renal dysfunction was 14.8% (four out of 27 cases), all classified as "injury" according to RIFLE criteria. The incidence of hyperpigmentation was 59.3%. Conclusion: Polymyxin B is a viable treatment option for granulocytopenia patients with refractory gram-negative bacterial bloodstream infections.


Subject(s)
Humans , Polymyxin B/adverse effects , Retrospective Studies , Gram-Negative Bacterial Infections/complications , Fever/drug therapy , Sepsis/drug therapy , Anti-Bacterial Agents/therapeutic use , Bacteremia/complications
8.
Chinese Journal of School Health ; (12): 834-838, 2022.
Article in Chinese | WPRIM | ID: wpr-934809

ABSTRACT

Objective@#To explore character strengths of college students who sought counseling, and its relationship with mental health.@*Methods@#A total of 180 college students who sought counseling were investigated by using the short version of Character Strengths Questionnaire and the Symptom Checklist 90 (SCL-90) during March 2020 to October 2021.@*Results@#The top five character strengths of college students who sought counseling were appreciation, authenticity, gratitude, humor, love of learning ( 8.39± 1.64, 7.82±1.74, 7.73±1.57, 7.29±1.81, 7.17±1.88); The bottom five character strengths were kindness, bravery, persistence, zest, leadership (5.59±1.75, 5.81±1.30, 5.86±1.72, 5.98±1.59, 6.06±1.60). Linear regression analysis found love, social intelligence and insight showed associations with different dimensions of mental health, with correlation coefficient of each regression equation between -0.12 and 0.16, and the coefficient of determination between 0.05 and 0.19 ( P <0.01). Love had a negativeassociation with all factors of SCL- 90 ( β=-0.314--0.159, P <0.05), which could explain 3.3%-12.5% of the variation of each factor. Social intelligence had a negative association with obsessive compulsive, interpersonal sensitivity and anxiety ( β=-0.200--0.150, P <0.05), which can explain 1.6%-3.2% of the variation. Insight had a positive association with somatization, hostility and paranoia ( β=0.168-0.279, P <0.05), which can explain 2.3%-3.8% of the variation.@*Conclusion@#The lack and excess of character strengths is associated with mental health problems. Therefore, it would be more effective to help counseling cases build an appropriate and balanced character in the context of a strengths based approach.

9.
Zhonghua Yu Fang Yi Xue Za Zhi ; (12): 567-573, 2022.
Article in Chinese | WPRIM | ID: wpr-935326

ABSTRACT

Objective: Predictive models were used to evaluate the impact of common risk factors on the number of cardio-cerebrovascular deaths and the probability of premature death. Methods: Using the data for China estimated by the Global Burden of Disease study 2015 (GBD 2015), we calculated the population attribution fraction (PAF) of risk factors. The proportional change model was used to estimate the number of unattributable deaths by 2030, and to predict the number of deaths, mortality, standardized mortality and probability of premature death by 2030. Results: According to the natural change trend of risk factors from 1990 to 2015, the number of deaths and mortality would reach 6.12 million and 428.53/100 000 by 2030, with an increase of 59.92% and 52.87%. By 2030, the probability of premature death from cardio-cerebrovascular diseases among Chinese aged 30-70 years old would continue to decline, from 11.43% to 11.28% for men, and from 5.79% to 4.43% for women. If the goals of all included risk factors were reached by 2030, 2 289 200 cardio-cerebrovascular deaths would be avoided. If only the exposure to a single risk factor was achieved by 2030, blood pressure, total cholesterol, and fine particulate matter exposure were the three most important factors affecting cardio-cerebrovascular deaths, which would reduce 1 332 800, 609 100 and 306 800 deaths, respectively. Among the involved risk factors, the control of blood pressure would mostly decrease the number of deaths due to ischemic heart disease and hemorrhagic stroke, about 677 300 and 391 100 deaths, accordingly. Conclusion: The control of risk factors is of great significance in reducing deaths and probability of premature death due to cardio-cerebrovascular diseases. If the control targets of all risk factors could be achieved by 2030, the burden of cardio-cerebrovascular diseases would be reduced greatly.


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Blood Pressure , Cerebrovascular Disorders/epidemiology , China/epidemiology , Mortality, Premature , Risk Factors
10.
Article in Chinese | WPRIM | ID: wpr-935347

ABSTRACT

Objective: To predict the number of deaths, standardized mortality and probability of premature mortality caused by malignant cancer in the context of risk factor control at different levels in China in 2030, and assess the possibility of achieving the target of reducing the probability of premature mortality of malignant cancer. Methods: According to the risk factor control standard for malignant cancer used both at home and abroad, the results of China from Global Burden of Disease Study 2015 were used to calculate the population attributable fraction of the risk factors. Based on the comparative risk assessment theory, the deaths of malignant cancer were classified as attributable deaths and un-attributable deaths. Proportional change model was used to predict risk factor exposure and un-attributable deaths of malignant cancer in the future, then the number of deaths, standardized mortality rate and probability of premature mortality of malignant cancer in 2030 was estimated. Data analyses were performed by using software R 3.6.1. Results: If the risk factor exposure level during 1990-2015 remains, the number of deaths, standardized mortality rate, and probability of premature mortality of malignant cancer would increase to 3.62 million, 153.96/100 000 and 8.92% by 2030, respectively. If the risk factor exposure control level meets the requirement, the probability of premature mortality from cancer in people aged 30-70 years would drop to 7.57% by 2030. Conclusions: The control of risk factor exposure will play an important role in reducing deaths, standardized mortality rate and probability of premature mortality of malignant cancer. But more efforts are needed to achieve the goals of Health China Action.


Subject(s)
Adult , Aged , Humans , Middle Aged , China/epidemiology , Cost of Illness , Mortality, Premature , Neoplasms/epidemiology , Risk Factors
11.
Chinese Journal of Epidemiology ; (12): 201-206, 2022.
Article in Chinese | WPRIM | ID: wpr-935371

ABSTRACT

Objective: To forecast the burden of chronic obstructive pulmonary disease (COPD) in China by 2030 and evaluate the effectiveness of controlling risk factors based on the predictive model. Methods: Based on the relationship between the death of COPD and exposure to risk factors and the theory of comparative risk assessment, we used the estimates of the Global Burden of Disease Study 2015 (GBD2015) for China, targets for controlling risk factors, and proportion change model to project the number of deaths, standardized mortality rate, and probability of premature mortality from chronic respiratory diseases by 2030 in different scenarios and to evaluate the impact of controlling the included risk factors to the disease burden of COPD in 2030. Results: If the trends in exposure to risk factors from 1990 to 2015 continued, the number of deaths and the mortality for COPD would be 1.06 million and 73.85 per 100 000 population in China by 2030, respectively, with an increase of 15.81% and 10.69% compared to those in 2015. Compared to 2015, the age-standardized mortality rate would decrease by 38.88%, and the premature mortality would reduce by 52.73% by 2030. If the smoking rate and fine particulate matter (PM2.5) concentration separately achieve their control targets by 2030, there would be 0.34 and 0.27 million deaths that could be avoided compared to the predicted numbers based on the natural trends in exposure to risk factors and the probability of premature death would reduce to 0.59% and 0.52%, respectively. If the control targets of all included risk factors were achieved by 2030, a total of 0.53 million deaths would be averted, and the probability of premature death would decrease to 0.44%. Conclusions: If the exposures to risk factors continued as showed from 1990 to 2015, the number of deaths and mortality for COPD would increase by 2030 compared to 2015, and the standardized mortality and the probability of premature death would decrease significantly, which would achieve the targets of preventing and controlling COPD. If the exposure to the included risk factors all achieved the targets by 2030, the burden of COPD would be reduced, suggesting that the control of tobacco use and air pollution should be enhanced to prevent and control COPD.


Subject(s)
Humans , Air Pollutants/analysis , Air Pollution/prevention & control , China/epidemiology , Cost of Illness , Environmental Exposure , Particulate Matter/analysis , Pulmonary Disease, Chronic Obstructive/prevention & control , Risk Factors
12.
Article in Chinese | WPRIM | ID: wpr-1014799

ABSTRACT

AIM: To investigate the influence of CYP3A5 gene polymorphism on the anti-hypertensive efficacy of calcium channel blocker in patients with ischemic stroke and hypertension. METHODS: A total of 108 cases of ischemic stroke patients with hypertension were included and divided into experimental group and control group, and 54 cases in each group, the experimental group selected amlodipine tablets and levamlodipine tablets respectively according to the results of genetic testing, while the control group selected amlodipine tablets, which in order to investigate the antihypertensive efficacy of the two groups. RESULTS: The effective rate of experimental group and control group was 77.78% and 57.41% (P 0.05). In the experimental group, the antihypertensive effect of GG and AG genotype patients after taking amlodipine tablets was significantly higher than that of AA type patients, and GG type patients had a stronger antihypertensive effect than AG type patients after taking amlodipine tablets. CONCLUSION: CYP3A5 gene polymorphism is very important for blood pressure control by calcium channel blockers in patients with ischemic stroke and hypertension.

13.
Article in Chinese | WPRIM | ID: wpr-906334

ABSTRACT

Objective:To observe the effect of modified Cangfu Daotantang on metabolism and pregnancy in patients with spleen deficiency and phlegm-dampness type polycystic ovary syndrome (PCOS). Method:One hundred and twelve patients were randomly divided into control group and observation group according to the random number table. Both groups took non-pharmacological interventions, oral metformin hydrochloride, 500mg/time, 3 times/day; oral ethinyl estradiol and cyproterone tablets, 1 tablet/time, 1 time/day, starting from the third to fifth day of menstruation and lasting for twenty-one days, for a total of 3 menstrual cycles. Patients in control group additionally took Erchen pills orally, 10 g/time, 2 times/day, while patients in observation group additionally took modified Cangfu Daotantang orally, 1 dose/day. The course of treatment was six menstrual cycles in both groups (or termination after conception). The waist-to-hip ratio (WHR), body mass index (BMI), insulin resistance index (HOMA-IR), pancreatic <italic>β</italic>-cell function (HOMA-<italic>β</italic>), triglycerides (TG), low-density lipoprotein (LDL) and non-high-density lipoprotein (nHDL) elevation after treatment were compared. The number of ovulation cycles monitored by B-ultrasound (6 menstrual cycles), ovulation rate, human chorionic gonadotropin (HCG) day endometrial thickness, follicle diameter, cervical mucus score>8 points and endometrial morphology type A rate were measured and recorded. The recovery of menstruation, pregnancy and early miscarriage were recorded. Luteinizing hormone (LH), estradiol (E<sub>2</sub>), follicle stimulating hormone (FSH), dehydroepiandrosterone sulfate (DHEAS), testosterone (T), anti-Müllerian hormone (AMH) levels, and insulin before and after treatment -Like growth factor-1 (IGF-1), leptin (LP), adiponectin (APN), growth differentiation factor-9 (GDF-9) and tumor necrosis factor-<italic>α</italic> (TNF-<italic>α</italic>) levels were detected. Result:WHR, BMI and HOMA-IR levels of the observation group were lower than those of the control group (<italic>P</italic><0.05, <italic>P</italic><0.01). HOMA-<italic>β</italic> level was higher than that in the control group (<italic>P</italic><0.01). The increase rates of LDL, TG, and nHDL in the observation group were 19.61%(10/51),25.49%(13/51),23.53%(12/51), respectively, lower than 41.18%(21/51),47.06%(24/51),45.10%(23/51)respectively in the control group (<italic>χ</italic><sup>2</sup>=5.607, <italic>χ</italic><sup>2</sup>=5.131, <italic>χ</italic><sup>2</sup>=5.263, <italic>P</italic><0.05). The menstrual recovery rate in the observation group was 90.20% (46/51), higher than 72.55% (37/51) in the control group (<italic>χ</italic><sup>2</sup>=5.239,<italic>P</italic><0.05). The observation group had more ovulation cycles than the control group (<italic>P</italic><0.01). The pregnancy rate in the observation group was 50.98% (26/51), higher than 31.37% (16/51) in the control group (<italic>χ</italic><sup>2</sup>=4.047,<italic>P</italic><0.05). On HCG day after treatment, the endometrial thickness and follicle diameter in the observation group were better than those in the control group (<italic>P</italic><0.01). The proportion of patients with cervical mucus score> 8 points was 78.43% (40/51) in the observation group, higher than 56.86% (29/51) in the control group (<italic>χ</italic><sup>2</sup>=5.420,<italic>P</italic><0.05). The intimal morphology type A rate in the observation group was 52.94% (27/51), higher than 31.37% (16/51) in the control group (<italic>χ</italic><sup>2</sup>=4.864,<italic>P</italic><0.05). The levels of AMH, E<sub>2</sub>, DHEAS, LH, T , IGF-1, LP and TNF-<italic>α</italic> in the observation group were lower than those in the control group (<italic>P</italic><0.01), while the APN and GDF-9 levels were superior to those in the control group (<italic>P</italic><0.01). Conclusion:On the basis of conventional western medicine intervention, modified Cangfu Daotantang can regulate abnormal metabolism and reproductive endocrine in patients with PCOS, improve conception, and regulate the expression of IGF-1, GDF-9, adipocytokines and inflammatory factors, improve ovulation and improve pregnancy rate.

14.
Journal of Experimental Hematology ; (6): 1940-1944, 2021.
Article in Chinese | WPRIM | ID: wpr-922228

ABSTRACT

OBJECTIVE@#To investigate the distribution of Rh phenotype, irregular antibodies screenting and postpartum follow-up of RhD@*METHODS@#The samples of 313 RhD@*RESULTS@#The Rh serological phenotypes of 313 RhD@*CONCLUSION@#The Rh serological phenotype of RhD


Subject(s)
Female , Humans , Infant, Newborn , Pregnancy , Blood Group Antigens , Hematologic Tests , Pregnant Women , Prenatal Diagnosis , Rh-Hr Blood-Group System
15.
Chinese Journal of Neuromedicine ; (12): 1237-1242, 2021.
Article in Chinese | WPRIM | ID: wpr-1035554

ABSTRACT

Objective:To explore the clinical features and treatment efficiencies of pediatric giant posterior fossa tumors.Methods:A retrospective analysis was performed. The clinical data of 18 children with giant posterior fossa tumors, whose maximum diameter of any section was over 5 cm, admitted to our hospital from January 2015 to June 2020, were collected. The surgical treatment results were analyzed.Results:The tumor volume of 18 children was (63.9±20.7) mL (33.2-116.2 mL). Sixteen children had different degrees of preoperative obstructive hydrocephalus; ommaya capsule implantation was performed in 2, ventriculoperitoneal shunt was performed in one, and external ventricular drainage was performed in one before surgery; intraoperative external ventricle drainage was performed in 5; and the left 7 had postoperative self-healing. Tumor resection was performed in 17 children, including 10 with total resection and 7 with subtotal resection. The postoperative pathological results indicated medulloblastoma in 10 patients, ependymoma in 3 patients, pilocytic astrocytoma in 2 patients, oligodendroglioma in 1 patient, and yolk sac tumor in 1 patient;12 patients were treated with chemotherapy and 9 with radiotherapy. Postoperative persistent hydrocephalus was noted in 2 patients, cerebellar mutism in 2 patients, and subarachnoid hemorrhage combined with ventricular hematocele in 1 patient. The follow-up period ranged from 3 to 67 months: 13 children survived for more than one year (10 lived without tumor recurrence); 8 of the 10 patients with total tumor resection had progression-free survival for more than 1 year (the other 2 patients were lost of follow-up), while 3 of the 7 patients with subtotal resection had progression-free survival for more than 1 year.Conclusion:Pediatric giant posterior fossa tumors have high complication rate, high recurrence rate and poor prognosis; symptomatic treatment, total resection of the tumors, and adjuvant radiotherapy/ chemotherapy are effective treatment methods.

16.
Biomed. environ. sci ; Biomed. environ. sci;(12): 444-447, 2020.
Article in English | WPRIM | ID: wpr-828995

ABSTRACT

Pseudorabies virus (PRV), a veterinary pathogen that infects domestic animals as well as wild animals such as wild boar and feral swine, was recently reported to infect human and led to endophthalmitis and encephalitis. A retrospective seroepidemiologic survey was conducted using 1,335 serum samples collected from patients with encephalitis and ELISA positive rates were 12.16%, 14.25%, and 6.52% in 2012, 2013, and 2017, respectively. The virus neutralizing antibody titers of positive samples correlated well with ELISA results. The pseudorabies virus antibody positive rate of patients with encephalitis were higher than that of healthy people in 2017. The above results suggest that some undefined human encephalitis cases may be caused by PRV infection.


Subject(s)
Adult , Animals , Female , Humans , Male , Middle Aged , Young Adult , Antibodies, Viral , Blood , China , Encephalitis , Allergy and Immunology , Virology , Enzyme-Linked Immunosorbent Assay , Herpesvirus 1, Suid , Allergy and Immunology , Prevalence , Pseudorabies , Blood , Allergy and Immunology , Virology , Retrospective Studies , Seroepidemiologic Studies
17.
Article in Chinese | WPRIM | ID: wpr-802605

ABSTRACT

Objective@#To understand the level of compassion satisfaction of medical oncology nurses and to explore the mediating effect of resilience in the relationship between empathy ability and compassion satisfaction of medical oncology nurses, and to investigate the moderating effect of social support in this mediating role.@*Methods@#A total of 291 medical oncology nurses from 7 general hospitals in Dalian were measured with self-made general questionnaire, professional quality of life scale, Chinese version of Jefferson empathy scale, perceived social support scale and Ego-Resiliency Scale.@*Results@#The scores of compassion satisfaction of medical oncology nurses was (34.79±5.87).Pearson correlation analysis showed that there was a significant positive correlation between empathy, resilience, social support and compassion satisfaction (r=0.222-0.402, P<0.01). Resilience partially mediated the relationship between empathy ability and compassion satisfaction, the value of mediating effect was 23.1% of the total effect. The effect of resilience and compassion satisfaction among medical oncology nurses was also moderated by social support, that is, social support regulates the latter half of the process of empathy, resilience and compassion satisfaction. The higher the level of social support, the stronger the mediating effect of empathy through resilience on compassion satisfaction.@*Conclusions@#The level of compassion satisfaction of medical oncology nurses in Dalian is low and needs to be improved. The are close relationships among empathy ability, resilience, social support and compassion satisfaction. It is a moderated mediating effect model. It is suggested that managers should pay attention to the role of psychological resilience and provide high-level social support to improve the level of compassion satisfaction of medical oncology nurses.

18.
Article in Chinese | WPRIM | ID: wpr-752565

ABSTRACT

Objective To understand the level of compassion satisfaction of medical oncology nurses and to explore the mediating effect of resilience in the relationship between empathy ability and compassion satisfaction of medical oncology nurses, and to investigate the moderating effect of social support in this mediating role. Methods A total of 291 medical oncology nurses from 7 general hospitals in Dalian were measured with self-made general questionnaire, professional quality of life scale, Chinese version of Jefferson empathy scale, perceived social support scale and Ego-Resiliency Scale. Results The scores of compassion satisfaction of medical oncology nurses was (34.79 ± 5.87).Pearson correlation analysis showed that there was a significant positive correlation between empathy, resilience, social support and compassion satisfaction (r=0.222- 0.402, P<0.01). Resilience partially mediated the relationship between empathy ability and compassion satisfaction, the value of mediating effect was 23.1% of the total effect. The effect of resilience and compassion satisfaction among medical oncology nurses was also moderated by social support, that is, social support regulates the latter half of the process of empathy, resilience and compassion satisfaction. The higher the level of social support, the stronger the mediating effect of empathy through resilience on compassion satisfaction. Conclusions The level of compassion satisfaction of medical oncology nurses in Dalian is low and needs to be improved. The are close relationships among empathy ability, resilience, social support and compassion satisfaction. It is a moderated mediating effect model. It is suggested that managers should pay attention to the role of psychological resilience and provide high-level social support to improve the level of compassion satisfaction of medical oncology nurses.

19.
Article in Chinese | WPRIM | ID: wpr-753116

ABSTRACT

Objective :To study sympathetic activity in aged patients with essential hypertension (EH) complicated left ven-tricular hypertrophy (LVH).Methods : A total of 248 aged EH patients were selected from our hospital from Jun 2015 to Jun 2017- According to blood pressure level ,they were divided into EH stage 1 group (n=78) ,stage 2 group (n=89) and stage 3 group (n=81).According to presence of LVH ,patients were divided into no LVH group (n=122) and complicat-ed LVH group (n=126).According to blood pressure level ,LVH patients were divided into stage 1 group (n=28) ,stage 2 group (n=41) and stage 3 group (n=57).Another 130 healthy aged people undergoing physical examination were regar-ded as normal aged group .Plasma norepinephrine (NE) and epinephrine (E) contents were measured and compared among all groups ,and 24h DCG was performed.Results :Compared with normal aged group ,there were significant rise in plasma contents of NE [ (238-33 ± 18-04) ng/L vs.(312-90 ± 23-20) ng/L ,(279-28 ± 20-85) ng/L] ,E [ (262-86 ± 24-56) ng/L vs.(366-57 ± 25-53) ng/L ,(301-20 ± 23-80) ng/L] in complicated LVH group and no LVH group ( P=0-001 all) ,and plasma NE and E contents gradually and significantly rose along with blood pressure stage rose , P=0-001 all. Compared with normal aged group ,there was significant rise in mean heart rate [ (64-80 ± 5-40) beats/min vs.(69-02 ± 4-56) beats/min ,(66-72 ± 4-98) beats/min] in complicated LVH group and no LVH group ( P=0-001 ,0-017) ;signif-icant reductions in SDNN [ (122-07 ± 7-73) ms vs.(109-51 ± 8-13) ms ,(99-25 ± 7-89) ms] ,SDANN [ (111-72 ± 13-33) ms vs.(103-52 ± 10-41) ms ,(94-78 ± 8-75) ms] ,rMSSD [ (43-98 ± 6-31) ms vs.(37-25 ± 6-42) ms ,(32-05 ± 5-19) ms] and PNN50 [ (7-67 ± 0-71)% vs.(5-41 ± 0-67)%,(3-39 ± 0-63)%] in no LVH group and complicated LVH group , P=0-001 all ,above indexes gradually and significantly reduced along with blood pressure stage rose , P=0-001 all.Conclusion :Sympathetic activity significantly elevates in aged EH + LVH patients.Controlling sympathetic ac-tivity will help to improve prognosis .

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Article in Chinese | WPRIM | ID: wpr-755171

ABSTRACT

Objective To study the diagnostic value of endoscopic ultrasonography (EUS) in patients with cholangiopancreatic duct dilatation (CPDD).Methods Forty-five patients with CPDD and without any visual or detected obstructive lesions after traditional uhrasonography (US) were re-examined by EUS,CT and MRI.The diagnostic rates of EUS and the other imaging technologies were compared.Results All the 45 patients underwent successful EUS examination.Among them,there were 18 patients with periampullary tumor,10 patients with lower common bile duct stones,1 patient with pancreatic duct stones,3 patients with chronic pancreatitis,1 patient with an intrapancreatic choledochal cyst,4 patients with inflammatory strictures of papilla of duodenum and 2 patients with terminal bile duct inflammatory stenosis.However,1 patient with a lower common bile duct tumor,1 patient with a small pancreatic head carcinoma and 1 patient with sphincter of Oddi dysfunction (SOD) were not diagnosed.The diagnostic rates of obstructive lesions by US,EUS,CT and MRI were 7.1%,92.9%,33.3%,31.0%,respectively.The diagnostic rates of tumor were 10.0%,90.0%,35.0%,25.0%,respectively.As compared with the other examination methods,EUS was best in detecting small carcinoma.Conclusion EUS plays an important role in the diagnosis of lesions causing cholangiopancreatic duct dilatation.

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