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1.
Basic & Clinical Medicine ; (12): 454-458, 2024.
Article in Chinese | WPRIM | ID: wpr-1018638

ABSTRACT

Objective To describe the incidence and mortality of brain tumors in China in 2020 and to predict the disease burden up to 2040.Methods The brain tumor incidence and mortality in 2020 were recorded based on the data from International Agency for Cancer Research(IARC),Cancer Today database.The incidence and mortality were standardized by age using Segi's world standard population.The burden of brain tumors in 2040 was predicted with assuming that national rates remained constant in 2020.Results It was estimated there were approximately 79 600 new brain tumors cases and 65 200 deaths in China in 2020.The age-standardized incidence and mortality rates of brain tumors in China were 4.1/100 000 and 3.2/100 000,respectively,which were lower than the United States of America,most of European countries and Australia.The incidence and mortality were higher than Africa,central America,and the Caribbean.From 2020 to 2040,the brain tumors cases and deaths are predicted to have an increase as 32.1%and 41.5%respectively.Conclusions The disease burden of brain tumors was still heavy in China.Further studies are urgently needed to clarify the epidemic trend of tissue typing and risk factors of brain tumors,which may support the development of effective prevention strategies.

2.
Article in Chinese | WPRIM | ID: wpr-994268

ABSTRACT

Objective:To investigate the Chinese anesthesiologist′s proficiency, training experience and needs of flexible bronchoscope-guided awake flexible bronchoscopy intubation (AFBI) using a questionnaire method.Methods:The cluster sampling was used, and self-designed questionnaires that addressed 54 questions in 5 categories were distributed through WeChat and online platforms. The survey took one month, and the answers were automatically recorded by the WeChat server.Results:A total of 1 250 anesthesiologists participated in the survey in 30 provinces of China, 9 of them were not anesthesiologists, and 1 241 (99.28%) questionnaires were validated. In the valid questionnaires, 52.70% (654) of the anesthesiologists were from tertiary hospitals, and 74.78% (928) of the anesthesiologists were attending physicians or above, only 7.57% (94) of the anesthesiologists had sufficient confidence in AFBI. Twenty-five point two two percent (313) of the anesthesiologists preferred fiberoptic intubation as the first tool when dealing with the anticipated difficult airway. Forty-eight point one one percent (597) of the anesthesiologists had implemented AFBI. Among them, 80.74% (482) had experienced unsuccessful AFBI practices. Eight hundred and ninety-four anesthesiologists had received AFBI training, and the most common AFBI training strategy was theoretical lectures. In addition, the degree of satisfaction regarding the theoretical lectures quality, technical training, clinical practice relativity and non-technical skills training was 21.47% (192), 14.32% (128), 12.3% (110) and 17.90% (160), respectively. The degree of satisfaction with all the 4 training elements mentioned above was 7.27% (65).Conclusions:The awareness and practice of Chinese anesthesiologists in terms of clinical application of AFBI to treat difficult airways need to be strengthened at present, and the lack of high-quality AFBI training may be the key.

3.
Article in Chinese | WPRIM | ID: wpr-955653

ABSTRACT

There are many difficulties in digital medical teaching, including new course content, multiple key and difficult points, wide knowledge coverage, large knowledge structure span, high requirements for teachers, and few shared resources for online teaching during the epidemic. This research aims to give full play to the advantages of our team in the field of digital medicine, and promote the construction of network resources of this course and its extensive development in more universities through the exploratory and research on the course construction and teaching mode of the Digital Medicine MOOC (massive open online course). The questionnaire study found that the satisfaction score of the average satisfaction score of MOOC teaching in terms of students' pre-class preview, quick grasp of knowledge points in class and after-class review reached more than 90 points, and the score of improving students' learning initiative was (88.10±10.87) points. It can be seen that the use of MOOC teaching mode can significantly help students to preview before class, master knowledge points in class and review after class, and improve students' initiative in learning. The research suggests that the production of Digital Medicine MOOC should keep the consistency and individuality of all knowledge points under the framework of digital medical knowledge; teachers should focus on the explanation of basic knowledge points and deepen in further step integrated with frontiers of this field; it’s suggested to make a separate MOOC on frontier knowledge and application explanation, so as to cope with the outdated courseware content caused by the development and update of this subject.

4.
Article in Chinese | WPRIM | ID: wpr-911586

ABSTRACT

Objective:To explore the diagnostic value of magnetic resonance imaging (MRI) for patients with pathologic nipple discharge.Methods:A retrospective analysis was made on patients with nipple discharge who underwent breast MRI and surgical excision between Oct 2010 to Oct 2020. Sensitivity, speci?city, positive predictive value, and negative predictive value of MRI were calculated.Results:A total of 184 patients fulfilled our selection criteria, including breast cancer in 43 cases (23.4%), intraductal papilloma in 96 cases (52.2%) and other benign diseases in 45 cases (24.5%). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of MRI for intraductal lesions of pathologic nipple discharge were respectively 76.8%, 52.2%, 82.8% and 42.9%. The sensitivity, specificity, PPV and NPV of MRI for pathologic malignant nipple discharge were respectively 97.7%, 41.1%, 33.6% and 98.3%. Among the 43 cases of breast cancer, 10 cases (23.3%) were occult malignancy with negative ultrasound and mammography and malignant lesions were detected by MRI. The sensitivity, specificity, PPV and NPV of MRI for occult malignancy were 81.8%, 53.7%, 24.4%, and 97.3%.Conclusion:MRI is a valuable additional diagnostic tool for the evaluation of pathologic nipple discharge, especially when conventional imaging is negative .

5.
Chinese Critical Care Medicine ; (12): 374-375, 2020.
Article in Chinese | WPRIM | ID: wpr-866817

ABSTRACT

Upper limb injury is a common disease in hand surgery. After surgery, it is necessary to raise the patient 's arm to reduce limb swelling and promote recovery. In clinic, clothes or pillows are usually placed under the arm to raise it, but in this way the arm cannot be fixed well and easily slide down, without ideal raising effect. Therefore, the upper limb raising pad for assisting the raising of the affected limb is specially designed. The device is composed of shell, mounting plate, strut, elastic band and spring. The position of the strut is adjusted by squeezing or lifting the spring, so as to change the inclination angle of the mounting plate and to adjust the raising height of the upper limb. After the height is determined, the affected limb is placed comfortably and then fixed with the elastic band. The device can freely adjust the raising height of the affected limb and effectively fix the affected limb to reduce its swelling, thus promoting recovery. This device is worthy to be clinically popularized and applied.

6.
Article in Chinese | WPRIM | ID: wpr-870416

ABSTRACT

Objective To verify that lncRNA-C21orF96 regulates the expression of miRNA-875-5p and USF2 genes and promotes the invasion and metastasis of gastric cancer.Methods RT-PCR was used to measure the expression of lncRNA-C21orF96 related miRNA in gastric cancer cells.pcDNA3.1 plasmid was used to over-express lncRNA-C21orF96 in KATO-Ⅲ and siRNA was used to knockdown the expression of lncRNA-C21orF96 in SGC-7901,and RT-PCR was used to measure the expression of miRNA-875-5p and USF2 genes;By overexpressing lncRNA-C21orF96 in MKN45,transwell was used to observe changes of cells invasion and migration.Results LncRNA-C21orF96 showed a significant inverse relationship with miR-875-5p,(SGC-7901:21.19 ±1.09 vs.3.28 ±0.06,P<0.01;SNU-16:24.76 ±2.09 vs.8.16 ±0.07,P < 0.01).In KATO-Ⅲ over-expressing lncRNA-C21 orF96,miR-875-5p expression decreased significantly while USF2 expression increased (P <0.01);In SGC-7901 with lncRNA-C21orF96 knockdown,miR-875-5p expression increased significantly while USF2 expression decreased (P < 0.05).The number of cells passing through the artificial basement membrane in the experimental group was significantly different from that in the control group (migration:216.19 ± 2.30 vs.89.19 ± 4.60,P<0.001;invasion:146.18 ±5.3 vs.59.18 ± 2.60,P < 0.001).Conclusions The overexpression of lncRNA-C21orF96 significantly reduces the expression of miR-875-5p and promotes the expression of USF2,hence promoting the invasion and metastasis of gastric cancer.

7.
Article in Chinese | WPRIM | ID: wpr-862157

ABSTRACT

Objective To investigate the value of mean platelet volume (MPV) combined with Gensini score in predicting short-term prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI). Methods A total of 186 patients with STEMI who underwent emergency PCI were enrolled. The relevant laboratory tests were completed before PCI, and MPV was detected. Gensini score was obtained according to the results of coronary angiography. The occurrence of major adverse cardiovascular events (MACE) after PCI was recorded. Then statistical analysis was performed. Results There were 36 patients with MACE after PCI (MACE group) and 150 patients without MACE (non-MACE group). The total cholesterol (TC), platelet count (Plt), D-dimer, N-terminal pro-brain natriuretic peptide (NT-proBNP), MPV, Gensini score and the proportion of lesions involving three vessels of coronary arteries were statistically different between the two groups (all P<0.05). MPV, Gensini score, Plt, NT-proBNP and lesions involving three vessels of coronary arteries were independent risk factors for MACE after PCI in patients with STEMI (all P<0.05). ROC analysis showed that the AUC for MPV (threshold as 0.86 fl) combined with Gensini score (threshold as 82.17) in predicting MACE in patients with STEMI after PCI was 0.92(95%CI [0.87, 0.98]), the sensitivity and specificity was 92.70% and 83.33%, respectively. Conclusion The occurrence of MACE in patients with STEMI after emergency PCI is related to MPV and Gensini score before intervention. MPV combined with Gensini score can be used to screen out high-risk patients.

8.
Zhonghua xinxueguanbing zazhi ; (12): 1000-1004, 2019.
Article in Chinese | WPRIM | ID: wpr-800150

ABSTRACT

Objective@#To investigate the prevalence characters of peripheral artery disease (PAD) and associated factors among people aged 35 and above in Beijing.@*Methods@#This was a cross-sectional study. A total of 5 208 community-based individuals aged equal and above 35 in Beijing were chosen with stratified multistage random sampling method. Structure questionnaire was used to collected the information of demographic factors, habits and chronic disease history. Ankle brachial blood pressure was detected and ankle brachial index (ABI) was calculated. ABI was used to diagnose PAD (ABI≤0.90). Based on the 2010 Beijing Municipal Population Census, the age-and gender-specific weight-adjusted sample was acquired to estimate the prevalence of PAD and corresponding 95% confidence intervals (CI). Multivariate logistic regression analysis was performed to estimate the associated factors of PAD.@*Results@#The age-and sex-standardized prevalence of PAD was 3.84% (200/5 208, 95%CI 3.32%-4.36%). There was no significant difference between male and female (3.83%(102/2 664, 95%CI 3.10%-4.56%) vs. 3.85% (98/2 544, 95%CI 3.10%-4.60%), P=0.965). The prevalence of PAD in urban was higher than that in rural (4.34% (163/3 755, 95%CI 3.69%-4.99%) vs. 2.55% (37/1 453, 95%CI 1.74%-3.36%), P=0.001). Furthermore, the prevalence of PAD increased with age (Ptrend<0.01), and the difference between genders did not change with ageing (all P>0.05). In addition, age (OR=1.03, 95%CI 1.01-1.04), urban (OR=1.52, 95%CI 1.08-2.12), smoking (OR=1.83, 95%CI 1.29-2.59), hypertension (OR=1.61, 95%CI 1.17-2.22) and diabetes (OR=1.44, 95%CI 1.08-1.93) were related with increased risk of PAD in logistic regression analysis models.@*Conclusions@#The prevalence of PAD increases with age in Beijing and there are significant difference between urban and rural on prevalence of PAD. Age, urban, smoking, hypertension and diabetes are related with increased risk of PAD.

9.
Article in Chinese | WPRIM | ID: wpr-805612

ABSTRACT

Objective@#To explore the effect of reconstructing the finger extension function by using partial flexor digitorum profundus tendon transposition.@*Methods@#Twelve patients were treated by using the partial proximal end of the tendon core of flexor digitorum profundus tendon regionⅠand part of region Ⅱ to cut off to the base of the distal digital phalanx, and puncturing at the end of the phalanx with a 2.0 drill. The tendon strips were pierced to the back overlap sutured to the proximal end of the avulsion of the extensor tendon .@*Results@#In 3-18 month follow-up, the average follow-up duration was 10.6 months. According to Dargan function evaluation method, 12 cases were excellent and one case was poor.@*Conclusions@#The method of reconstructing the extensor tendon by partial flexor deep tendon is a reliable method for the treatment of Mallet finger.

10.
Article in Chinese | WPRIM | ID: wpr-754608

ABSTRACT

Gauze packing and drainage is a routine treatment for various types of fistula and sinus pressure ulcers. Because the external orifice of pressure ulcer or fistula is relatively small and the sinus deep, the conventional gauze packing has many drawbacks. Under the situation the operator is not skillful enough and no appropriate tools, it is necessary to pull the external orifice by tweezers to dilate the sinus and perform gauze packing and drainage, which brings great pain to patients, possibly leading to wound enlargement and delayed healing. At present, there is lack of auxiliary tools to improve gauze packing. Therefore, we developed and designed a gauze filler for packing and drainage of various kinds of fistula and sinus pressure ulcers, the device has the following advantages: good drainage effect, simple operation, low cost, safety and effectiveness. It not only improves the comfort of patients, reduces the number of dressing changes, reduce the number of dressing changes, shorten the hospitalization time and pay expense, but also reduces the burden of medical workers thus it is worthwhile to popularize and apply the newly designed gauze filler in clinical practice.

11.
Article in Chinese | WPRIM | ID: wpr-755844

ABSTRACT

Objective To evaluate the oncological safety of axillary reverse mapping in patients with breast cancer.Methods Patients with sentinel lymph node biopsy(SLNB) or axillary lymphnode dissection (ALND) between Oct 2015 and Feb 2016 were enrolled in this study prospectively.Axillary reverse mapping (ARM) procedure was done using a radioisotope before the surgery.All the ARM nodes were identified and sent separately for histologic analysis.Results 78 patients underwent 78 axillary operations.Of 53 patients with SLNB,33 (62.3%)had ARM nodes identified.22 (41.5%)had the crossover of the ARM nodes with the SLNs,and one (4.5%) had positive ARM node.Of 36 patients with ALND,33 (91.7%) had ARM nodes identified.9(25%)had positive ARM nodes.Positive ARM node status was significantly associated with advanced axillary disease(P =0.036).Conclusion Preserving ARM nodes in SLNB is oncologically safe to reduce upper extremity lymphedema.

12.
Journal of Practical Radiology ; (12): 1743-1746, 2019.
Article in Chinese | WPRIM | ID: wpr-789935

ABSTRACT

Objective To evaluate the value of barium esophagography and CT in the diagnosis of congenital pyriform sinus fistula (CPSF).Methods The preoperative radiographic data of 5 9 CPSF patients were analyzed retrospectively,which were confirmed by operation.5 5 patients underwent barium esophagography,and 5 7 patients underwent pre-and post-contrast CT scans.The images of barium esophagography and CT were analyzed and the positive diagnostic rates (PDR)between the two imaging modalities and among the different CT features were compared.Results Among the 5 9 patients,left fistula was found in 5 5 cases,right fistula was found in 2 cases and bilateral fistula in 2 cases.For the patients examined with barium esophagography,53 sinus tracts or fistulas from the pyriform in 52 patients(including 2 patients with bilateral fistula)were depicted.The other 3 patients had negative results.The overall PDR of barium esophagography was 93.0%(53/57).CT findings of CPSF included the narrowness of pyriform fossa,sinus tract or fistula in the neck,bubble sign medial to the superior pole of thyroid,low density in thyroid,thyroid morphologic change,and so on.For the 5 7 patients (including 2 patients with bilateral fistula)examined with CT.The PDR of narrowness of pyriform fossa was 44.1%(26/59),the PDR of sinus tract or fistula was 1 3.6%(8/5 9),the PDR of bubble sign medial to the superior pole of thyroid was 55.9%(33/5 9),the PDR of low density in thyroid was 1 6.9%(1 0/5 9),the PDR of thyroid morphologic change(defect sign of superior pole of thyroid)was 9 1.5%(54/5 9 ).And the total PDR of thyroid density or morphologic change was 94.9%(56/59).Conclusion Barium esophagography can be the main modality to diagnose CPSF because of its high PDR.Although the PDR of CT for direct sign(sinus tract or fistula)is not high,its PDR for indirect sign (thyroid density or morphologic change)is very high.So CT has great value for patients suspected of CPSF.

13.
Article in Chinese | WPRIM | ID: wpr-806067

ABSTRACT

Objective@#To observe and study clinical efficacy of restruction of finger pulp using tibial flap.@*Methods@#From January 2009 to October 2013, we reconstructed the 20 finger pulps with free tibial flap of the second toe.@*Results@#20 flaps survived completely and were followed up for 6 months to 2 years, with an average of 1 year. There were no obvious scars in the reconstructive finger pulps. And the reconstructed finger pulps all had good appearance, texture, a fingerprint point discrimination at 6-8 mm, and finger function recovered well.@*Conclusions@#The shape of finger pulp after reconstuction with the free tibial flap of the second toe has the similar appearance to the normal finger pulp and a good sensory function, which is one of the best ways to reconstruct the finger pulp defects.

14.
Article in Chinese | WPRIM | ID: wpr-806892

ABSTRACT

Objective@#To investigate the effect of free abdominal flap in repairing soft tissue defects of the foot.@*Methods@#From 2011.10 to 2017.11, there were 5 patients whose foot had soft tissue defect, in order to repairing, we had to do debridment at the early time, then made the anterior iliac artery or the inferior epigastric artery as the axial vessel.@*Results@#After the flap transplantation there was no vascular crisis in the 5 patients , followed up for 3 months to 1 years, the blood supply, texture, elasticity and the foot was well in shape and feeling, the patients were satisfied, and the feet were functionally normal.@*Conclusions@#The application of free abdominal skin flap covers the soft tissue defect of the foot, the wound surface, the blood vessel the donor site is consistent, the flap is easy to prepare, and the area can be sutured directly, this is an effective treatment method.

15.
Chinese Journal of Epidemiology ; (12): 179-183, 2018.
Article in Chinese | WPRIM | ID: wpr-736461

ABSTRACT

Objective To investigate the rates on prevalence,awareness,treatment and control of hypertension in population older than 15 years of age in Beijing,2013-2014.Methods A cross-sectional survey was conducted in Beijing between 2013-2014.Stratified multistage random sampling method was used to select representative sample of 13 057 Chinese individuals aged over 15 years,from the general population.Blood pressure was measured for three readings at sitting position after resting for at least five minutes with an average reading recorded.A standardized structured questionnaire was developed to collect history of hypertension and antihypertensive treatment.Results A total of 4 663 community residents aged over 15 years were hypertensive among the 13 057 individuals,with the standardized prevalence rate as 32.7%,in Beijing area.The age-standardized prevalence rates of hypertension appeared 34.6% in men and 30.8% in women.The age-and sexstandardized prevalence of hypertension rates were 33.3% in urban and 24.6% in rural areas.The prevalence of hypertension increased with age and appeared higher in men than in women,in urban than in rural residents.Among the hypertensive patients,rates of awareness,treatment and control were 66.8%,64.6% and 31.6%,respectively.Conclusion High prevalence of hypertension with low rates on awareness and treatment and control,appeared in the general population of Beijing.Related strategies should be developed regarding prevention,control and management of hypertension,to reduce the burden of this disease.

16.
Chinese Journal of Epidemiology ; (12): 179-183, 2018.
Article in Chinese | WPRIM | ID: wpr-737929

ABSTRACT

Objective: To investigate the rates on prevalence, awareness, treatment and control of hypertension in population older than 15 years of age in Beijing, 2013-2014. Methods: A cross-sectional survey was conducted in Beijing between 2013-2014. Stratified multistage random sampling method was used to select representative sample of 13 057 Chinese individuals aged over 15 years, from the general population. Blood pressure was measured for three readings at sitting position after resting for at least five minutes with an average reading recorded. A standardized structured questionnaire was developed to collect history of hypertension and antihypertensive treatment. Results: A total of 4 663 community residents aged over 15 years were hypertensive among the 13 057 individuals, with the standardized prevalence rate as 32.7%, in Beijing area. The age-standardized prevalence rates of hypertension appeared 34.6% in men and 30.8% in women. The age-and sexstandardized prevalence of hypertension rates were 33.3% in urban and 24.6% in rural areas. The prevalence of hypertension increased with age and appeared higher in men than in women, in urban than in rural residents. Among the hypertensive patients, rates of awareness, treatment and control were 66.8%, 64.6% and 31.6%, respectively. Conclusion: High prevalence of hypertension with low rates on awareness and treatment and control, appeared in the general population of Beijing. Related strategies should be developed regarding prevention, control and management of hypertension, to reduce the burden of this disease.


Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Age Distribution , Antihypertensive Agents/therapeutic use , Asian People/statistics & numerical data , Awareness , Blood Pressure , Blood Pressure Determination , China/epidemiology , Cross-Sectional Studies , Health Knowledge, Attitudes, Practice , Hypertension/epidemiology , Prevalence , Rural Population , Sex Distribution , Surveys and Questionnaires , Urban Population
17.
Article in Chinese | WPRIM | ID: wpr-700242

ABSTRACT

Objective To investigate the prevalence and risk factors of H-type hypertension among middle-aged and elderly people in Beijing community. Methods A cross-sectional study by recruiting 1 458 middle-aged and elderly people from a cohort of the "Beijing Longitudinal Study of Aging" in 2009 was conducted. All participants were asked to complete a standardized questionnaire, physical examination and laboratory examinations. Hyperhomocysteinemia was defined as homocysteine (Hcy) > 15 μmol/L, and H- type hypertension was defined as having hypertension and hyperhomocysteinemia simultaneously. The prevalence of H-type hypertension was estimated by using the results of 2000 Beijing population census to weight the data. Multivariate Logistic regression analysis was preformed to estimate the associated factors of H-type hypertension. Results The age was (69.48 ± 8.09) years, and the distribution of Hcy was skewed with the median of 16.56 μmol/L. After weight, the prevalence of hyperhomocysteinemia was 57.20% (834/1 458), and the prevalence of H-type hypertension was 35.32% (515/1 458), accounting for 59.47% (515/866) in patients with hypertension. The ageing, male, hyperuricemia, estimated glomerular filtration rate (eGFR) and insufficiency of fishes/ shrimps were independent risk factors of H-type hypertension ( OR = 2.30, 1.04, 1.02, 0.95 and 0.67; 95% CI 1.54-3.44, 1.02-1.06, 1.04-1.06, 0.94-0.97 and 0.46-0.97; P<0.01 or<0.05). Conclusions The proportion of H-type hypertension is high in the middle-aged and elderly people in Beijing community. Lowering uric acid, protection of renal function and intake sufficient fishes and shrimps might prevent and control H-type hypertension.

18.
Journal of Chinese Physician ; (12): 342-346, 2018.
Article in Chinese | WPRIM | ID: wpr-705830

ABSTRACT

Objective To investigate the effect of long-term walking exercise on the health status of low-labor-intensity population under long-term walking exercise.Methods A total of 100 volunteer teachers from universities in Beijing were enrolled.After physical examination,they were randomly divided into control group and observation group.The observation group regularly carried out corresponding encouragingactivities and recorded the daily number of steps.The corresponding indexes were measured again after 450 days.Results 45.24% participants in the observation group got more than 75% participation rate.The lower the participation rate,the lower the average daily steps (P < 0.05).The fasting blood glucose,systolic blood pressure,LDL and total cholesterol were lower than other groups in the group participation rate <25% (P <0,05).The body mass index,systolic blood pressure,fasting blood glucose,total cholesterol,ratio diabetes and hypertension in low activities group (< 7 500 steps/day) were lower than those in other groups (P < 0.05).Conclusions Walking exercise can achieve good long-term persistence with constant feedback.For those who are older and whose initial indicators are higher,participation rate and exercise volume are more likely to be better under the guidance of encouragement.Persisting long-term walking exercise can help reduce blood pressure and blood lipids.

19.
Article in Chinese | WPRIM | ID: wpr-706929

ABSTRACT

Objective To investigate the effects of Shenfu injection on early post-operative cognitive dysfunction (POCD) and brain derived neurotrophic factor (BDNF) in patients with burns. Methods Fifty-six patients with burns and ready to receive surgical treatment of scars admitted to Affiliated Hospital of Southwest Medical University from July 2015 to January 2017 were enrolled, and they were divided into a control group and a Shenfu group by random number table, 28 cases in each group. The regimen of anesthesia induction before operation and anesthesia maintenance in the operation in two groups was the same, and the patients in Shenfu group received intravenous drip of Shenfu injection 40 mL at 0.5 hour before surgery. The Mini-mental State Examination Scale (MMSE) was used to evaluate the cognitive function after surgery, and MMSE score reduction of > 2 scores was recognized as cognitive impairment after operation;patient's pain degree was evaluated by using visual analogue scale (VAS); the levels of serum BDNF were detected by the enzyme-linked immunosorbent assay (ELISA) at 0.5 hour before operation, immediately after operation, and 12 hours, 1 day, 3 days after operation. Results The MMSE scores were significantly decreased in the two groups after surgery, but decreasing degree of the MMSE scores in Shenfu group were significantly slower than those of the control group (1 day after surgery was 22.8±2.9 vs. 20.5±3.2, 3 days after surgery was 25.6±3.1 vs. 23.2±3.0, both P < 0.05). The incidence of POCD in the Shenfu group was significantly lower than that of the control group [7.1% (2/28) vs. 42.9% (12/28), P < 0.05]. The VAS scores were significantly higher in the two groups after surgery, but there was no significant difference between the two groups at each time point (all P > 0.05). The serum BDNF levels were significantly increased in two groups at immediate post-operation and 12 hours after surgery compared with those 1 day before operation, in addition, the BDNF level in Shenfu group was obviously higher than that in the control group (mg/L: 13.5±4.2 vs. 9.9±3.3, 11.4±3.5 vs. 9.1±3.2, both P < 0.05), the serum BDNF levels in two groups returned to their preoperative levels on 1 day and 3 days after surgery (all P > 0.05). Conclusion The Shenfu injection can reduce the incidence of early POCD in patients with large area burns and its mechanism may be related to the increase of BNDF expression.

20.
Article in Chinese | WPRIM | ID: wpr-710609

ABSTRACT

Objective To evaluate the long-term safety of sentinel lymph node biopsy mapped by combination of indocyanine green and methylene blue in breast cancer patients.Methods 198 breast cancer patients with clinical negative axillary lymph node received sentinel lymph node biopsy mapped by combination of indocyanine green and methylene blue.Patients were followed up and regional lymph node recurrence,disease free survival(DFS) and overall survival(OS) were analyzed.Results After a median follow-up of 70 months,2 patients had ipsilateral lymph node recurrence with a regional lymph node recurrence rate of 1% (2/198).14 patient had recurrence or metastasis and 6 patients died of distant metastasis.The estimated 6 years DFS was 94.4% and OS was 96.5%.The incidence of arm lymphoedema within patients who received axillary lymph node dissection was 4.5% and it was 2.5% in patients who received sentinel lymph node biopsy.Conclusions The sentinel lymph node biopsy mapped by combination of indocyanine green and methylene blue was safe and reliable method for further staging axillary lymph node stastus.

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