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1.
Asian Journal of Andrology ; (6): 300-305, 2021.
Article in English | WPRIM | ID: wpr-879751

ABSTRACT

We performed this study to investigate the diagnostic performance of prostate-specific antigen density (PSAD) in a multicenter cohort of the Chinese Prostate Cancer Consortium. Outpatients with prostate-specific antigen (PSA) levels ≥4.0 ng ml

2.
Article in Chinese | WPRIM | ID: wpr-873746

ABSTRACT

Objective To investigate the distribution and changing trend of canine echinococcosis in Inner Mongolia Autonomous Region, so as to provide the scientific evidence for prevention and control of canine echinococcosis in high-risk areas of Inner Mongolia Autonomous Region. Methods All data pertaining to Echinococcus infections in canine feces and sampling survey of human echinococcosis were collected from the echinococcosis-endemic foci of Inner Mongolia Autonomous Region from 2012 to 2018, and the prevalence of Echinococcus infections was investigated in dogs and humans. In addition, the spatial distribution characteristics and clusters of canine echinococcoses were identified. Results A total of 164 139 canine fecal samples were detected in the echinococcosis-endemic foci of Inner Mongolia Autonomous Region from 2012 to 2018, and there were 2 136 fecal samples positive for Echinococcus coproantigens. The positive rates of Echinococcus coproantigens were 0.54% to 1.73% in dogs from 2012 to 2018, with a tendency towards a decline seen in the prevalence of Echinococcus infections in dogs (χ2 = 108.83, P < 0.01), and there was a significant difference in the positive rate of Echinococcus coproantigens in dogs among years (χ2 = 155.27, P < 0.01). Three-dimensional trend analysis showed that canine echinococcosis was mainly concentrated in east of central Inner Mongolia Autonomous Region, and a high prevalence was detected in New Barag Right Banner and Sonid Right Banner. The global spatial distribution of canine echinococcosis appeared a random pattern in Inner Mongolia Autonomous Region from 2012 to 2018 (Moran’s I > 0, P > 0.05), and there were “high-high” and “high-low” clusters of canine echinococcosis in local areas. The prevalence of human echinococcosis was 0.08%, and there was a significant difference in the prevalence among regions (χ2 = 147.61, P < 0.01), with a high prevalence seen in West Ujimqin Banner, Jarud Banner and New Barag Right Banner. In addition, the prevalence of human echinococcosis correlated positively with the Echinococcus coproantigen-positive rate in dogs (r = 0.52, P < 0.01). Conclusions The prevalence of Echinococcus infections shows an overall tendency towards a decline in dogs in Inner Mongolia Autonomous Region from 2012 to 2018, with a high prevalence found in New Barag Right Banner and Sonid Right Banner. Human echinococcosis is concentrated in clusters of canine echinococcosis, where health education and targeted control interventions requires to be intensified.

3.
Article in English | WPRIM | ID: wpr-878336

ABSTRACT

Objective@#Evidence is lacking regarding the combined effects of smoking and obesity on mortality from coronary heart disease in male veterans. This study aimed to explore the combined effect of smoking and obesity on coronary heart disease mortality in male veterans in China.@*Methods@#A cohort of 1,268 male veterans from 22 veteran centers in Xi'an (Shaanxi Province, China) were followed up once every 2 years from February 1, 1987 to October 30, 2016. The endpoint was death from any cause. The hazard ratio ( @*Results@#The total follow-up was 24394.21 person-years; each subject was followed up for a mean duration of 19.24 years. By the end of the study, of the 1,268 veterans, 889 had died, 363 were alive, and 16 were lost to follow-up. Cox regression analysis results revealed that current smoking ( @*Conclusion@#Our results suggest that obese veterans who smoke might be an important target population for coronary heart disease mortality control.


Subject(s)
Aged , China/epidemiology , Coronary Disease/mortality , Humans , Male , Middle Aged , Obesity/complications , Proportional Hazards Models , Risk Factors , Smoking , Veterans/statistics & numerical data
4.
Acta Physiologica Sinica ; (6): 175-180, 2021.
Article in English | WPRIM | ID: wpr-878246

ABSTRACT

The great omentum is an intraperitoneal organ and plays an important role in protecting the environment of the peritoneal cavity. Several specialized innate immune cells including B1 cells and resident macrophages are found in the omentum, which may be attributed to the unique niche and its special stromal cells. However, it is not clear how these omental innate immune cells contribute to the peritoneal immunity. This review attempts to summarize the latest research on the omental innate immunity and discuss its involvement in the immune response of the peritoneal cavity.


Subject(s)
Immunity, Innate , Macrophages , Omentum , Peritoneal Cavity , Stromal Cells
5.
Article in Chinese | WPRIM | ID: wpr-863263

ABSTRACT

Objective To investigate the epidemiological characteristics and its associated risk factors of lower urinary tract symptoms in young Chinese obese males.Methods A total of 126 young males aged 20-40 years admitted to Beijing Friendship Hospital,Capital Medical University were enrolled into two different groups in this study,including 74 obese patients visited metabolic weight loss clinic were included in the experimental group,and 52 conditionally healthy persons were included in the control group.Blood pressure (systolic blood pressure,diastolic blood pressure),insulin resistance (fasting blood glucose,insulin,C-peptide),blood lipid metabolism (triglycerides,high-density lipoprotein cholesterol),and sex hormones (estrogen) of the two groups of subjects.Hormones,serum testosterone),C-reactive protein (CRP),International prostate symptom score (IPSS) and quality of life score (QOL).were compared between the two groups of subjects.Comparisons of measurement data between groups were statistically analyze by t test,expressed by mean ± standard deviation (Mean ± SD);the correlation between body mass index and LUTS was analyzed by Spearman rank correlation,and the risk factors of LUTS and clinical variables were analyzed by univariate logistic regression.The significant variables were analyzed by multivariate logistic regression.Results There were significant statistical differences between experimental group and control group in terms of systolic blood pressure [(144.30 ± 15.78) mmHg vs (125.9 ±66.11) mmHg,P<0.001],diastolic blood pressure [(89.46 ± 12.76) mmHg vs (81.35 ±4.58) mmHg,P =0.001],and fasting blood glucose [(6.73 ± 3.15) mmol/L vs (5.26 ± 1.47) mmol/L,P =0.016],insulin [(26.60 ± 19.09) mg/dLvs (13.43 ±7.68) mg/dL,P<0.001],C-peptide [(4.20±1.73) ng/mL vs (1.59 ± 0.52) ng/mL,P=0.001],triglycerides [(2.42 ± 1.88) mg/dL vs (1.45 ± 0.79) mg/dL,P =0.007),estrogen [(52.32±21.77) ng/L vs (42.11 ± 12.19) ng/L,P =0.023] and CRP [(6.49±4.96) mg/L vs (1.62 ±1.53) mg/L,P =0.037],but no statistical difference regarding high-density lipoprotein [(1.10 ± 0.55) mg/dL vs (1.06 ±0.26) mg/dL,P =0.669] and serum testosterone [(275.00 ± 100.68) ng/dL vs (280.28 ± 85.52) ng/dL,P =0.823].In addition,the experimental group had higher IPSS [(3.81 ± 1.88)scores vs (0.69 ±0.30) scores,P <0.001] and QOL scores [(2.76 ±0.68) scores vs (0.12 ±0.08) scores,P<0.001] than the control group,and higher risk of LUTS [86.49% vs 42.31%,P < 0.001],especially moderate LUTS (21.62% vs 0,P =0.011).Spearman rank correlation analysis showed that obesity (body mass index≥30 kg/m2) was significantly associated with moderate LUTS risk (r =0.407,P < 0.001);Univariate logistic regression analysis showed that systolic blood pressure,insulin,and C-peptide were important risk factors of moderate LUTS in young obese patients (P =0.009,0.029,0.002).Systolic blood pressure and fasting C-peptide were independent risk factors by multivariate logistic regression analysis (P =0.011,0.003).Conclusions The middle severity of LUTS was prevalent in young obese males,and systolic blood pressure and C-peptide were its significant independent risk factors.

6.
Article in Chinese | WPRIM | ID: wpr-872364

ABSTRACT

Coding system is the basis of delicacy and informatization management of medical supplies, and is the link between enterprise production and clinical use. Rational construction of coding system can realize dynamic analysis of big data, guide clinical use, improve the use efficiency, and form a traceability system. Coordinating with medical security standardization work guidance, the authors analyzed the characteristics of current classification, and constructed a new medical supplies coding system by combining the clinical characteristics, price supervision, level of risk, properties of medical charge and insurance, production date and traceability, etc. This new medical supply coding system could contribute to analyzing the usage structure and strengthening price supervision, medical supplies classification and traceability management, which could be appropriate for the monitoring of the whole supply chain, from production, logistics, procurement, supplies usage, charge, medical insurance to traceability management.

7.
Article in Chinese | WPRIM | ID: wpr-865528

ABSTRACT

Objective:To investigate the effect of placement error on target volume and critical structure in intensity modulated radiation therapy (IMRT) in patients with nasopharyngeal carcinoma.Methods:The study period was from January 2018n to March 2019.The 60 patients with nasopharyngeal carcinoma who were treated in Zhejiang Cancer Hospital for this period and received radiation therapy were treated with simultaneous integration and intensity-modulated radiation therapy.The total tumor volume and clinical setting were set. The target volume and low-risk lymph node area were 70.0, 59.4 and 54.0 Gy respectively, with a total of 33 divisions; 3, 5 and 10 mm were moved around the top, bottom, left and right to simulate the placement error; the average dose, the maximum dose, the planned target volume and >110% and <93% prescription dose were evaluated. For both parotid glands, the average dose and >50% parotid gland dose was evaluated; the maximum dose and 2 cc spinal cord tolerance dose were analyzed.Results:Compared with no displacement, the maximum percentage change in the average dose of the total tumor volume (GTV-70 Gy) at the center displacement of 3 mm was smaller (2.2%), and the maximum percentage changes of the average dose at the center displacement of 5mm and 10mm were 6.4% and 16.0% respectively.; Analysis of clinical target volume (CTV) and planned target volume (PTV) dose volume analysis of different displacements showed that the average volume of CTV-54 Gy was (112.06 ± 55.92) cc (range 50.6-243.8 cc), compared to V54 (%) The maximum percentage changes of center displacements of 3, 5 and 10 mm were 1.5%, 6.8% and 23.8%. The positioning error of 3mm along the posterior and lateral sides can significantly affected the dose of the spinal cord; the positioning error along the lateral and anterior directions could significantly affect the dose of the parotid glands on both sides. The maximum average dose produced by the left displacement under the same conditions was (46.38 ± 5.35) Gy.Conclusions:In the intensity-modulated radiotherapy for nasopharyngeal carcinoma, the position error should be confirmed regularly at the same time to achieve a better target volume dose and improve the treatment effect.

8.
International Journal of Surgery ; (12): 614-619, 2020.
Article in Chinese | WPRIM | ID: wpr-863389

ABSTRACT

Objective:To analyze the risk factors of stress urinary incontinence after transurethral enucleation of prostate.Methods:A retrospective analysis of the clinical data of 326 patients who underwent transurethral enucleation of prostate at the Beijing Friendship Hospital, Capital Medical University due to benign prostatic hyperplasia from March 2016 to December 2019. Patients were divided into stress urinary incontinence group ( n=78) and non-stress urinary incontinence group ( n=248) according to whether there was stress urinary incontinence one week after the catheter was removed. Age, body mass index, hypertension, diabetes, hyperlipidemia, prostate volume, the time of lower urinary tract symptoms (LUTS), total prostate specific antigen, preoperative indwelling catheter status, operation type, operation time, percentage of hemoglobin reduction and catherization time were compared between the two groups. Measurement data were expressed as mean±standard deviation ( Mean± SD), and t-test was used for comparison between groups; Chi-square test or Fisher exact probability method was used for comparison of count data between groups. Single factor and multivariate Logistic regression analysis were used to screen independent predictors. Results:Age [(73.9±7.3) years vs (69.5±7.8) years, P<0.001], body mass index [(25.6±3.0) kg/m 2vs (24.6±2.9) kg/m 2, P=0.004], the time of LUTS [(5.42±5.65) years vs (5.05±5.19) years, P=0.008], and hypertension (57.7% vs 43.6%, P=0.037), prostate volume [(77.1±33.2) mL vs (62.5±30.2) mL, P<0.001], operation time [(115.0±45.7) min vs (99.8±41.4) min, P=0.006] in stress urinary incontinence group were significantly higher than those in the non-stress urinary incontinence group, the differences were statistically significant. Age ( OR=1.05, 95% CI: 1.02-1.07, P<0.001), body mass index ( OR=1.08, 95% CI: 1.03-1.14, P=0.003), LUTS ( OR=1.21, 95% CI: 1.14-1.29, P=0.015)and prostate volume ( OR=1.11, 95% CI: 1.10-1.11, P=0.011) were independent risk factors for stress urinary incontinence after transurethral enucleation of prostate by multivariate Logistic regression analysis. Conclusion:Age≥70years, body mass index≥25 kg/m 2, LUTS during≥5 years and prostate volume≥75 mL are independent risk factors for stress urinary incontinence after transurethral enucleation of prostate.

9.
Chinese Medical Journal ; (24): 2295-2301, 2020.
Article in English | WPRIM | ID: wpr-826593

ABSTRACT

BACKGROUND@#Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events. This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions.@*METHODS@#Consecutive patients with coronary heart disease who underwent two serial coronary angiographies were included. All coronary non-target lesions were recorded at first coronary angiography and analyzed using quantitative coronary angiography at both procedures. Patients were grouped into non-smokers, quitters, and smokers according to their smoking status. Clinical outcomes including rapid lesion progression, lesion re-vascularization, and myocardial infarction were recorded at second coronary angiography. Multivariable Cox regression analysis was used to investigate the association between smoking status and clinical outcomes.@*RESULTS@#A total of 1255 patients and 1670 lesions were included. Smokers were younger and more likely to be male compared with non-smokers. Increase in percent diameter stenosis was significantly lower (2.7 [0.6, 7.1] % vs. 3.5 [0.9, 8.9]%) and 3.4 [1.1, 7.7]%, P = 0.020) in quitters than those in smokers and non-smokers. Quitters tended to have a decreased incidence of rapid lesions progression (15.8% [76/482] vs. 21.6% [74/342] and 20.6% [89/431], P = 0.062), lesion re-vascularization (13.1% [63/482] vs. 15.5% [53/432] and 15.5% [67/431], P = 0.448), lesion-related myocardial infarction (0.8% [4/482] vs. 2.6% [9/342] and 1.4% [6/431], P = 0.110) and all-cause myocardial infarction (1.9% [9/482] vs. 4.1% [14/342] and 2.3% [10/431], P = 0.128) compared with smokers and non-smokers. In multivariable analysis, smoking status was not an independent predictor for rapid lesion progression, lesion re-vascularization, and lesion-related myocardial infarction except that a higher risk of all-cause myocardial infarction was observed in smokers than non-smokers (hazards ratio: 3.00, 95% confidence interval: 1.04-8.62, P = 0.042).@*CONCLUSION@#Smoking cessation mitigates the increase in percent diameter stenosis of coronary non-target lesions, meanwhile, smokers are associated with increased risk for all-cause myocardial infarction compared with non-smokers.

10.
Article in Chinese | WPRIM | ID: wpr-825232

ABSTRACT

Objective To investigate the epidemiological characteristics of human echinococcosis in Inner Mongolia Autonomous Region, so as to provide evidence for the development of the precision control strategy of human echinococcosis in the region. Methods A sampling survey of human echinococcosis was conducted in 28 banners (counties, districts) of Inner Mongolia Autonomous Region from 2012 to 2017, and the epidemiological characteristics were descriptively analyzed. Results A total of 90 058 residents were examined for echinococcosis in 28 banners (counties, districts) of Inner Mongolia Autonomous Region from 2012 to 2017, and 71 patients were detected with echinococcosis, with a detection rate of 0.08%. No echinococcosis cases were identified in 8 banners (counties), and there were 6 banners (counties) with echinococcosis prevalence of 0.1% to 1%, and 14 with prevalence of 0 to 0.1%. The echinococcosis prevalence was significantly greater in women (0.11%) than in men (0.05%) (χ2 = 10.09, P = 0.001), and the highest prevalence was detected in patients at ages of over 50 years (38 cases, 53.52%). In addition, the highest echinococcosis prevalence was detected in herdsmen (0.14%), or in primary school children (0.13%). Conclusions Human echinococcosis is widely, but lowly prevalent in Inner Mongolia Region, with a diverse density of infections. Echinococcosis has remarkable characteristics of regional and population clusters in Inner Mongolia Region, and the management of echinococcosis requires to be reinforced in key regions and populations.

11.
Journal of Medical Postgraduates ; (12): 708-714, 2020.
Article in Chinese | WPRIM | ID: wpr-822588

ABSTRACT

ObjectiveThe methods based on bladder cancer markers which could be applied to early diagnosis and postoperative recurrence monitoring of bladder cancer were current research hotspots. This study aims to screen aptamers that specifically recognize human bladder cancer cell lines (EJ, T24, BIU87) through cell-based systematic evolution of ligand by exponential enrichment (CELL-SELEX).MethodsFor CELL-SELEX screening, bladder cancer cell lines EJ, T24, and BIU87 were used as positive control cells. HCV 29 (human normal urothelial cell line), 293T (human embryonic kidney cell line), huh7 (human hepatocellular carcinoma cell line) were used as negative control cells. PCR upstream primers were labeled with FITC, downstream primer was labeled with Biotin. ssDNA fragments collected from each round were amplified by PCR, and the amplified product was then purified using a DNA purification Kit. The biotin-streptavidin magnetic separation methods were used to isolate the PCR product to obtain secondary FITC-ssDNA for the next CELL-SELEX round. The screening process was monitored by flow cytometry. ssDNA pool with the highest binding rates to bladder cancer cell lines(EJ, T24, and BIU87) was selected to PCR amplification, product purification, molecular cloning, and sequencing. According to the sequencing results, the secondary structure of the aptamer was pre-simulated by Dnaman software. Aptamer labeled with FITC was synthesized in vitro, flow cytometry was used to detect the binding rate of the aptamer to bladder cancer cell lins (EJ, T24 and BIU87).ResultsWith the advance of the CELL-SELEX process, the binding rate of FITC-ssDNA to bladder cancer cell lins (EJ, T24, and BIU87) increased gradually. By the 15th round, the binding rate of FITC-ssDNA to EJ cells reached the highest level. The apt1 had the highest enrichment among the 15th round ssDNA pool. By the 18th round, the binding rate of FITC-ssDNA to T24 or BIU87 cells reached the highest level. The apt2 and apt3 had the highest enrichment among the 18th round ssDNA pool. DNA structure prediction showed that the secondary structure of apt1, apt2, and apt3 was mainly stem-loop structure. Flow cytometry showed that the highest binding rate was FITC-apt1 to EJ cells, FITC-apt2 to T24 cells, and FITC-apt3 to BIU87 cells, respectively. There is no significant combination between these aptamers with the negative cells.ConclusionIn this study, three kinds of aptamers with high specificity for bladder cancer cell lines were successfully screened by CELL-SELEX. The apt1 can specifically recognize EJ cells, apt2 can specifically recognize T24 cells and apt3 can specifically recognize BIU87 cells, all of which provide experimental evidence for early diagnosis and targeted therapy technology research of bladder cancer.

12.
Article in Chinese | WPRIM | ID: wpr-821649

ABSTRACT

Objective To investigate the spatial distribution patterns and changing tendency of reported echinococcosis patients in Inner Mongolia Autonomous Region from 2013 to 2018, so as to provide the evidence for the management of echinococcosis in high-risk areas. Methods All data pertaining to echinococcosis patients in Inner Mongolia Autonomous Region were captured from the National Notifiable Communicable Disease Reporting System from 2013 to 2018 and analyzed using a spatial epidemiological method. Results The incidence of reported echinococcosis was 0.22 to 0.41 per 100 000 in Inner Mongolia Autonomous Region from 2013 to 2018, and the number of banner reporting echinococcosis patients increased from 24 in 2013 to 39 in 2018. The highly prevalent areas of echinococcosis were mainly concentrated in West Ujimqin Banner (the highest incidence, 19.23 per 100 000), East Ujimqin Banner (the highest incidence, 12.93 per 100 000) and New Barag Right Banner (the highest incidence, 11.66 per 100 000). Three-dimensional trend analysis showed that the areas with high incidence of reported echinococcosis were mainly located in central by eastern parts of Inner Mongolia Autonomous Region. There was a positive spatial autocorrelation in the number of echinococcosis patients, and the cases appeared a clustering distribution (Moran’s I > 0, P < 0.05), with “high-high” and “low-high” regions. Conclusion The reported echinococcosis patients show a spatial aggregation in Inner Mongolia Autonomous Region, and the hotspot areas are mainly concentrated in Xilingol League and Chifeng City, in which targeted control interventions for Inner Mongolia Autonomous Region are recommended to be intensified.

13.
Article in English | WPRIM | ID: wpr-828987

ABSTRACT

Objective@#To determine the factors influencing insomnia and construct early insomnia warning tools for rescuers to informbest practices for early screening and intervention.@*Methods@#Cluster sampling was used to conduct a cross-sectional survey of 1,133 rescuers from one unit in Beijing, China. Logistic regression modeling and R software were used to analyze insomnia-related factors and construct a PRISM model, respectively.@*Results@#The positive rate of insomnia among rescuers was 2.74%. Accounting for participants' age, education, systolic pressure, smoking, per capita family monthly income, psychological resilience, and cognitive emotion regulation, logistic regression analysis revealed that, compared with families with an average monthly income less than 3,000 yuan, the odds ratio ( ) values and the [95% confidence interval ( )] for participants of the following categories were as follows: average monthly family income greater than 5,000 yuan: 2.998 (1.307-6.879), smoking: 4.124 (1.954-8.706), and psychological resilience: 0.960 (0.933-0.988). The ROC curve area of the PRISM model (AUC) = 0.7650, specificity = 0.7169, and sensitivity = 0.7419.@*Conclusion@#Insomnia was related to the participants' per capita family monthly income, smoking habits, and psychological resilience on rescue workers. The PRISM model's good diagnostic value advises its use to screen rescuer early sleep quality. Further, advisable interventions to optimize sleep quality and battle effectiveness include psychological resilience training and smoking cessation.


Subject(s)
Adolescent , Adult , China , Epidemiology , Cross-Sectional Studies , Humans , Incidence , Income , Male , Models, Theoretical , Occupational Diseases , Epidemiology , Rescue Work , Resilience, Psychological , Risk Factors , Sleep Initiation and Maintenance Disorders , Epidemiology , Smoking , Epidemiology , Socioeconomic Factors , Young Adult
14.
Article in Chinese | WPRIM | ID: wpr-799270

ABSTRACT

Objective@#To investigate the epidemiological characteristics and its associated risk factors of lower urinary tract symptoms in young Chinese obese males.@*Methods@#A total of 126 young males aged 20-40 years admitted to Beijing Friendship Hospital, Capital Medical University were enrolled into two different groups in this study, including 74 obese patients visited metabolic weight loss clinic were included in the experimental group, and 52 conditionally healthy persons were included in the control group. Blood pressure (systolic blood pressure, diastolic blood pressure), insulin resistance (fasting blood glucose, insulin, C-peptide), blood lipid metabolism (triglycerides, high-density lipoprotein cholesterol), and sex hormones (estrogen) of the two groups of subjects. Hormones, serum testosterone), C-reactive protein (CRP), International prostate symptom score (IPSS) and quality of life score (QOL). were compared between the two groups of subjects. Comparisons of measurement data between groups were statistically analyze by t test, expressed by mean ± standard deviation (Mean±SD); the correlation between body mass index and LUTS was analyzed by Spearman rank correlation, and the risk factors of LUTS and clinical variables were analyzed by univariate logistic regression. The significant variables were analyzed by multivariate logistic regression.@*Results@#There were significant statistical differences between experimental group and control group in terms of systolic blood pressure [(144.30±15.78) mmHg vs (125.9±66.11) mmHg, P<0.001], diastolic blood pressure [(89.46±12.76) mmHg vs (81.35±4.58) mmHg, P=0.001], and fasting blood glucose [(6.73±3.15) mmol/L vs (5.26±1.47) mmol/L, P=0.016], insulin [(26.60±19.09) mg/dL vs (13.43±7.68) mg/dL, P<0.001], C-peptide [(4.20±1.73) ng/mL vs (1.59±0.52) ng/mL, P=0.001], triglycerides [(2.42±1.88) mg/dL vs (1.45±0.79) mg/dL, P=0.007), estrogen [(52.32±21.77) ng/L vs (42.11±12.19) ng/L, P=0.023] and CRP [(6.49±4.96) mg/L vs (1.62±1.53) mg/L, P=0.037], but no statistical difference regarding high-density lipoprotein [(1.10±0.55) mg/dL vs (1.06±0.26) mg/dL, P=0.669] and serum testosterone [(275.00±100.68) ng/dL vs (280.28±85.52) ng/dL, P=0.823]. In addition, the experimental group had higher IPSS[(3.81±1.88) scores vs (0.69±0.30) scores, P<0.001] and QOL scores [(2.76±0.68) scores vs (0.12±0.08) scores, P<0.001] than the control group, and higher risk of LUTS [86.49% vs 42.31%, P<0.001], especially moderate LUTS ( 21.62% vs 0, P=0.011). Spearman rank correlation analysis showed that obesity (body mass index≥30 kg/m2) was significantly associated with moderate LUTS risk (r=0.407, P<0.001); Univariate logistic regression analysis showed that systolic blood pressure, insulin, and C-peptide were important risk factors of moderate LUTS in young obese patients (P=0.009, 0.029, 0.002). Systolic blood pressure and fasting C-peptide were independent risk factors by multivariate logistic regression analysis (P=0.011, 0.003).@*Conclusions@#The middle severity of LUTS was prevalent in young obese males, and systolic blood pressure and C-peptide were its significant independent risk factors.

15.
Article in Chinese | WPRIM | ID: wpr-743893

ABSTRACT

BACKGROUND: Intra-articular injection of sodium hyaluronate can safely and effectively treat knee osteoarthritis and obviously improves the pain and function of knee joint. The efficacy of extracorporeal shock wave therapy for early-and middle-term knee osteoarthritis still remains controversial. OBJECTIVE: To compare the effects of extracorporeal shock wave therapy and intra-articular injection of sodium hyaluronate for early-and middle-term knee osteoarthritis. METHODS: According to the inclusion criteria, a total of 77 patients with knee osteoarthritis were enrolled, and randomly divided into extracorporeal shock wave therapy group and sodium hyaluronate therapy group. The extracorporeal shock wave therapy group underwent 5 sessions of 2 000 shockwave pulses performed on the affected knee with the dosage adjusted to 0.2 mJ/mm2 energy. The sodium hyaluronate group was administered intra-articularly sodium hyaluronate once per week for 5 weeks. The results were assessed with the Visual Analogue Scale, Lequesne index and Western Ontario and McMaster Universities Osteoarthritis Index. RESULTS AND CONCLUSION:① After 5 weeks of treatment, the Visual Analogue Scale, Western Ontario and McMaster Universities Osteoarthritis Index and Lequesne index in the two groups were significantly decreased compared with the baseline (P < 0.05). All above indexes in the extracorporeal shock wave therapy group were significantly lower than those in the sodium hyaluronate therapy group (P < 0.05).② These results indicate that the extracorporeal shock wave therapy and sodium hyaluronate therapy are effective for early-and middle-term knee osteoarthritis, and the former is more significant.

16.
Article in Chinese | WPRIM | ID: wpr-742779

ABSTRACT

OBJECTIVE To explore the mechanism of Aurora kinase A (Aurora-A) promoting cancer cell chemotherapy resistance in nasopharyngeal carcinoma. METHODS The expression of Aurora-A in nasopharyngeal carcinoma tissues and adjacent tissues were detected by Western bolt and Q-PCR. The highexpressing Aurora A cell line CNE2 was used to detected the cell apoptosis and the expression of key pathway marker protein after Aurora-A inhibitor VX680 and cisplatin treatment by using Flow cytometry and WB. RESULTS The expression of Aurora-A in nasopharyngeal carcinoma tissues was significantly higher than that in adjacent tissues. Comparing to normal nasopharyngeal cells NP69, Aurora-A was significantly highly expressed in all of nasopharyngeal carcinoma cells and was highest in CNE2. Inhibiton of Aurora-A increased the cell apoptosis and the expression of p-AKT, p21 and Cleaved-Caspase-3 after using cisplatin or the Aurora-A inhibitor VX680 treatment. CONCLUSION The results shown that Aurora-A confer chemoresistance to cisplatin treatment through p-AKT/p21/Cleaved-Caspase-3 pathway.

17.
Article in Chinese | WPRIM | ID: wpr-824368

ABSTRACT

Objective To analyze the epidemiological characteristics and its trends of other infectious diarrhea diseases in infants in Inner Mongolia Autonomous Region.Methods Statistical analysis was conducted on other infectious diarrhea cases of infants in Inner Mongolia Autonomous Region from China Information System for Disease Prevention and Control from 2005 to 2016.The main methods were descriptive epidemiology for population,area and time distribution of these registered cases in Inner Mongolia Autonomous Region.The trends were analyzed by the ratio of fixed base and ring base.Area map method was used for regional differences.Results From 2005 to 2016,17 760 other infectious diarrhea diseases of infants were reported in Inner Mongolia Autonomous Region,accounting for 58%of the total reposed cases.The cases number and incidence showed an overall upward trend.After 2011,the growth rate of case reports and incidences slowed down relatively.The peak of the incidence was in July and August(4 739 cases),accounting for27%of cases of the whole year.Seventy-three point forty-four percent of the cases were located in Hulunbeier City(5 161 cases,29.06%),Hohhot City(4 465 cases,25.14%)and Baotou City(3 417 cases,19.24%).Except for Wuhai City.the remaining 11 cities showed increased incidence of other infectious diarrhea diseases in infants.The ratio of male to female was 1.55∶1,and the incidence in males was higher than that in females every year.Twelve-month-old(5 800 cases,33%)had the greatest proportion.Clinical diagnosis(56.26%)and confirmed diagnosis(43.51%)were the main categories,but the rate of pathogen labeling was only 7.60%.Conclusions After 2011,the incidence of other infectious diarrhea diseases of infants in Inner Mongolia Autonomous Region have slowed down relatively.However,the incidence has significant time,region and population aggregation.

18.
Article in Chinese | WPRIM | ID: wpr-819008

ABSTRACT

Objective To evaluate the role of polysaccharide from Phellinus igniarius (PPI) in the improvement of oxidative stress, hepatic granuloma and hepatic fibrosis in Schistosoma japonicum-iniected in mice. Methods The mouse model of schistosomiasis was established by S. japonicum cercariae infection via the abdomen. Balb/c mice were randomly assigned into 5 groups, including the healthy control group (Group A), infection control group (Group B), PPI treatment group (Group C), praziquantel treatment group (Group D) and PPI-praziquantel combination group (Group E), of 10 mice in each group. Each mouse in groups B, C, D and E was infected with (30 ± 2) S. japonicum cercariae. Then, mice in groups D and E were given praziquantel by gavage at a dose of 500 mg/kg for successive two days on day 42 post-infection, while mice in groups C and E were given PPI by gavage at a dose of 400 mg/kg for successive 30 days on day 42 post-infection. Histopathological changes of hepatic tissues were observed using hematoxylin-eosin (HE) staining, and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN) were determined, while the activities of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), glutathione reductase (GSH-R) and glutathione (GSH) were detected in Mouse liver homogenates. The expression of transforming growth factor-beta (TGF-β) and alpha-smooth muscle actin (α-SMA) was quantified in hepatic tissues using immunohistochemistry, and the Nrf2 and Gsta4 gene expression was quantified using quantitative real-time PCR (qPCR) assay. Results Untreated mice presented typical pathological changes of schistosomal hepatic disorders, while PPI treatment effectively alleviated hepatic egg granulomas and collagen deposition. S. japonicum infection resulted in aggravation of hepatic lipid peroxidation, induction of oxidative stress, elevated serum MDA level and a reduction in the activity of GSH and antioxidant enzymes activities in mice. As compared to infected but untreated mice, PPI treatment suppressed hepatic lipid peroxidation, increased the GSH activity and restored the activity of antioxidant enzymes. In addition, PPI treatment inhibited the TGF-β signaling pathway and up-regulated the Nrf2 and Gsta4 gene expression. Conclusions PPI plays a critical role in the treatment of schistosomiasis-induced hepatic fibrosis. It may improve oxidative stress damages through up-regulating Nrf2 and Gsta4 gene expression, thereby suppressing the development of hepatic egg granulomas and hepatic fibrosis.

19.
Article in Chinese | WPRIM | ID: wpr-818588

ABSTRACT

Objective To evaluate the role of polysaccharide from Phellinus igniarius (PPI) in the improvement of oxidative stress, hepatic granuloma and hepatic fibrosis in Schistosoma japonicum-iniected in mice. Methods The mouse model of schistosomiasis was established by S. japonicum cercariae infection via the abdomen. Balb/c mice were randomly assigned into 5 groups, including the healthy control group (Group A), infection control group (Group B), PPI treatment group (Group C), praziquantel treatment group (Group D) and PPI-praziquantel combination group (Group E), of 10 mice in each group. Each mouse in groups B, C, D and E was infected with (30 ± 2) S. japonicum cercariae. Then, mice in groups D and E were given praziquantel by gavage at a dose of 500 mg/kg for successive two days on day 42 post-infection, while mice in groups C and E were given PPI by gavage at a dose of 400 mg/kg for successive 30 days on day 42 post-infection. Histopathological changes of hepatic tissues were observed using hematoxylin-eosin (HE) staining, and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN) were determined, while the activities of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), glutathione reductase (GSH-R) and glutathione (GSH) were detected in Mouse liver homogenates. The expression of transforming growth factor-beta (TGF-β) and alpha-smooth muscle actin (α-SMA) was quantified in hepatic tissues using immunohistochemistry, and the Nrf2 and Gsta4 gene expression was quantified using quantitative real-time PCR (qPCR) assay. Results Untreated mice presented typical pathological changes of schistosomal hepatic disorders, while PPI treatment effectively alleviated hepatic egg granulomas and collagen deposition. S. japonicum infection resulted in aggravation of hepatic lipid peroxidation, induction of oxidative stress, elevated serum MDA level and a reduction in the activity of GSH and antioxidant enzymes activities in mice. As compared to infected but untreated mice, PPI treatment suppressed hepatic lipid peroxidation, increased the GSH activity and restored the activity of antioxidant enzymes. In addition, PPI treatment inhibited the TGF-β signaling pathway and up-regulated the Nrf2 and Gsta4 gene expression. Conclusions PPI plays a critical role in the treatment of schistosomiasis-induced hepatic fibrosis. It may improve oxidative stress damages through up-regulating Nrf2 and Gsta4 gene expression, thereby suppressing the development of hepatic egg granulomas and hepatic fibrosis.

20.
Article in Chinese | WPRIM | ID: wpr-813066

ABSTRACT

Giant cell reparative granuloma (GCRG) is a type of non-neoplastic lesion that can be rarely found in clinical practices. Due to the lack of specificity in symptoms, signs and auxiliary examinations, it is likely to be misdiagnosed, and thereby affecting the treatment and prognosis. In July 2018, a GCRG patient who was described with "4 years of hearing loss in the left ear, accompanied by 2 months of preauricular swelling" as the first symptom was admitted in our hospital. Both the HRCT and MRI scans for the temporal bone suggested the presence of tumor at the left lateral skull base, but the nature still needed further examination. Intraoperatively, the tumor was completely removed and repaired locally. Pathological examination confirmed the symptoms as GCRG. Immunohistochemistry showed the expression of CD68 and CD163 in the tumor cells. Postoperatively, the patient recovered well without complications, and had the stitches removed before being discharged on schedule.


Subject(s)
Bone Neoplasms , Giant Cell Tumors , Giant Cells , Granuloma, Giant Cell , Humans , Temporal Bone
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