ABSTRACT
Study on the acute toxicity of Hypericum japonicum and Hypericum patulum to determine the ability to treat some diseases of liver. Haft of the upper of Hypericum japonicum Thumb. ex Murr. collected in April, when it having flowers in Ha Tay province. Raw materials have been dried in shade to compound extracts to the experiments. The leaves of Hypericum patulum Thumb. ex Murr. collected in October in Sa Pa. Raw materials have been dried, compounded extracts and mixed the water by this method. Results have shown that at indicated doses, the herbs show no acute toxicity
Subject(s)
Toxicity , Hypericum , Plant ExtractsABSTRACT
Water extract of Hypericum patulum Thumb. ex Murr. has been proved to possess the effects of decreasing GPT hepatoyeast and bilirubin, inhibiting anti-cirrhotic, decreasing the amount of colagen by 26.4%, antioxidant, amount of MDA of the treated mice decreased by 22.62%. Water extract of Hypericum patulum Thumb. ex Murr. has chronic anti - inflammatory effect on the model causing experimental granuloma, reducing the mass of tumor by 30.22%. In addition, water extract of Hypericum patulum Thumb. ex Murr. has clearly choleretic activities, increasing the number of producing bile by 78.55% as compared with physiological control group. Water extract of Hypericum patulum Thumb. ex Murr. has promising for a medicament for chronic hepatitis activity.