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1.
Journal of Practical Radiology ; (12): 1676-1680, 2019.
Article in Chinese | WPRIM | ID: wpr-789927

ABSTRACT

Objective To compare the values of the lung nodule image quality by using two adaptive statistical iterative reconstruction (ASIR)in a chest phantom CT imaging study.Methods Non-enhanced CT of chest phantom with routine dose was obtained on both GE Discovery CT and Revolution CT.The scan parameters included tube voltage of 120 kVp,a noise index of 14 HU,slice thickness of 5 mm.All scans were reconstructed with FBP and different percentages of (20%-100% ASIR)when using Discovery CT,and different percentages of ASIR-V (20%-100% ASIR-V)when using Revolution CT.The CT attenuation values and SD (the SD represented image noise)of the subcutaneous uniform tissue were measured at the level of thoracic entry,trachea carina and hepatic portal.Based on the standard FBP(FBPs )algorithm,the image noise reduction rate of reconstructed images using different iterative percentage of standard algorithms ASIR and ASIR-V(ASIRs and ASIR-Vs )were compared.The paired t test was used to compare the noise of ASIRs and ASIR-Vs images under the same iterative percentage.The subj ective image quality was independently evaluated by two experienced radiologists,Kappa test was used to evaluate consistency,Wilcoxon test was used to compare subjective scores.Results For all ASIRs and ASIR-Vs images,the objective image noise of subcutaneous uniform tissue decreased along with increasing percentage.Comparison with the average noises of CT image reconstructed with the FBPs algorithm,the image noise reconstructed with ASIRs from 20% to 1 00% were reduced by 1 1.0 6%-48.9 7%,while the image noise reconstructed with ASIR-Vs from 20% to 100% were reduced by 17.06%-79.50%.The image noise of different percentage ASIR-Vs was significantly lower than that of same percentage ASIRs between 40% and 1 00% (P<0.05 ).In terms of subj ective image evaluation,all ASIR1 and ASIR-V1 reconstructions had good diagnostic acceptability.Two readers scored good or moderate consistency in each iterative reconstruction of each lung nodule.Nodules of smaller size and less dense were more likely to have score differences.The 60%ASIR1 showed significantly superior visibility of lung nodules when compared to other percentages (P<0.05).60% and 80% ASIR-V1 series showed significantly superior visibility of lung nodules when compared to the 60% ASIR1 and ASIR-V1 of other percentages (P<0.05).Conclusion In routine dose non-enhanced chest CT, ASIR-V shows greater potential in reducing image noise and improves lung nodule image quality when compared to the same level ASIR algorithm. Combining both the obj ective and subj ective evaluation of images,reconstructed with 60% and 80% ASIR-V in the non-enhanced chest CT image is recommended for the observation and evaluation of pulmonary nodules.

2.
Journal of Practical Radiology ; (12): 634-637,646, 2019.
Article in Chinese | WPRIM | ID: wpr-752412

ABSTRACT

Objective Toexploretheroleofmodel-basediterativereconstruction (MBIR)algorithminimprovingthequalityof thyroidCTimagesbyreducinghardeningartifactsattheentrancetothethorax.Methods ChestCTscansof20patientswiththyroidnoduleswere retrospectivelyreviewed.AlgorithmsofFBP,ASIR40,MBIRSTNDandMBIRNR40 wereusedtoreconstructatthe0.625mmslicethickness.Region ofinterestwasplacedonthecoronalimageswiththemostobvioushardeningartifacts.ThestandarddeviationsoftheCTvaluesof theleftandrightthyroidarteriesandthesurroundingnormalthyroidtissueweremeasured,furthermore,thevalueofthyroidartifact index(AI)andAI=sqrt(SDa2-SDb2)werecalculated.Tworadiologistsused4-pointmethodtoassessimageartifactssubjectivly.(1 point,severeartifacts,unclearthyroidrimsandnodules,undiagnosed;2points,moderateartifacts,poorlydisplayingthyroid margins andinternaldetails,affectivediagnosis;3points,mildartifacts,showingthyroid marginandinternaldetails,noaffectingthediagnosis;4 points ,no ribbon artifacts ,displaying thyroid edge and internal details very w ell ).ANOVA and paired t-test w ere used to co m pare the CTvaluesofnormalthyroidtissueofleftandrightlobeamongdifferentreconstructedimagesofthyroid.Subjectivescoredifferenceswere testedusingthe W ilcoxon symbolscale.Results ThevalueofCTreductionandAIatFBPandASIR40reconstructionimagesweresignificantly greaterthanthoseatMBIRSTNDandMBIRNR40reconstructionimages. Whiletherewerenodifferenceofleftandrightlobeofthyroid CTreductionand AIvalueatFBPand ASIR40reconstruction imagesnorthoseatMBIRSTNDandMBIRNR40reconstructionimages. SubjectiveevaluationofclavicleartifactswasincreasedatMBIRSTND and MBIRNR40image,andMBIRNR40imagehadoptimalsubjectiveevaluationresults(P<0.05).Conclusion MBIRcansignificantlyreducethe impactoftheclavicularharnesshardeningartifactsandnoiseonthethyroidanditsnodulesduringCTscans,especiallyoptimizingthe low-densitycontrastsettingofMBIRNR40.

3.
Acta Physiologica Sinica ; (6): 511-520, 2018.
Article in Chinese | WPRIM | ID: wpr-687800

ABSTRACT

Hypoxic exposure activates hypoxia inducible factors (HIFs) to up-regulate the expression of its target genes. These genes encode glucose metabolism related proteins, such as glucose transporters (GLUTs) and glycolysis related enzymes, including lactate dehydrogenase A (LDHA) and aldolase A (ALDA). Therefore, HIFs participate in oxygenolysis of glucose and play an important role in mediating hypoxia response and weight loss. Exercise training influences fatty acid metabolism, insulin sensitivity and body energy balance through activating peroxisome proliferator-activated receptors (PPARs), which plays an active role in losing weight. In addition, hypoxic exposure or exercise training can activate energy sensor 5'-AMP activated protein kinase (AMPK) in cells and promote oxidation of glucose and fatty acid and weight loss. It has been shown that hypoxic training exerts a better effects on controlling weight, compared with either hypoxic exposure or exercise training alone. This paper reviewed synergistic interactions among HIFs, PPARs and AMPK under hypoxic training and proposed possible mechanisms of hypoxic training-induced weight loss via AMPK-HIFs axis or AMPK-PPARs axis, thus providing theoretical guidance for application of hypoxic training in weight control.

5.
China Pharmacy ; (12): 115-118, 2017.
Article in Chinese | WPRIM | ID: wpr-507832

ABSTRACT

OBJECTIVE:To prepare total flavonoids of Hippophae rhamnoides(TFH)-PVP K30 solid dispersion,and to char-acterize and study its in vitro dissolution. METHODS:Solvent method was used to prepare TFH-PVP K30 solid dispersion with dif-ferent drug-loading ratio of 1:1,1:2,1:3,1:4,1:5;single factor test was designed to screen drug-loading ratio using dissolution parameter Td as index;orthogonal test was designed to optimize ultrasonic time,temperature of water bath and drying time for prep-aration technology using in vitro dissolution rate as index,and then validated. SEM,DSC and FT-IR were used to characterize sol-id dispersion. RESULTS:Td of TFH-PVP K30 solid dispersion was the lowest when drug-loading ratio was 1:3. Optimal technolo-gy was ultrasonic time 10 min,temperature of water bath 60 ℃ and drying time 12 h. 90 min accumulative dissolution rate of pre-pared TFH-PVP K30 solid dispersion was 90.22% in average(RSD=1.74%,n=3). The results of SEM,DSC and FT-IR showed that the drug as amorphous form dispersed in the PVP K30,the formation of hydrogen bond of the both. CONCLUSIONS:TFH-PVP K30 solid dispersion is prepared successfully,and in vitro dissolution rate of it is improved significantly.

6.
Article in Chinese | WPRIM | ID: wpr-693345

ABSTRACT

Objective To investigate the relationship between methylation of CpG island in glutathione S-transferase P1(GSTP1) promoter region and injury induced by isoniazid in HL-7702 cells.Methods HL-7702 cells were divided into the control group and three isoniazid groups(200,400,800 mg/L).Colorimetric method was used to detect the activity level of lactate dehydrogenase in the medium of HL-7702 cells;the mRNA expression of GSTP1,DNA methyltransferases 1(DNMT1),DNMT3a and DNMT3b were de?tected by real-time fluorescence quantitative PCR;the protein expression levels of DNMT1,DNMT3a and DNMT3b were detected by enzyme-linked immunosorbent assay;the methylation of the CpG island in the GSTP1 promoter region was determined by the bisulfite sequencing PCR.Results The activity level of lactate dehydrogenase in supernatants of the HL-7702 cells in isoniazid group(400, 800 mg/L)was higher than that in the control group(P<0.01).Compared with the control group,the mRNA expression of DNMT 1、3a、3b and GSTP1 were elevated in 400 and 800 mg/L isoniazid groups(P<0.05,P<0.01).The proteins expression of DNMT1 and 3a in the 400 and 800 mg/L isoniazid groups were higher than that in the control group(P<0.05,P<0.01),and the protein expression of DNMT 3b in the 800 mg/L isoniazid groups were higher than that in the control group(P<0.01).The methylation level of CpG is?land in GSTP1 promoter region of three isoniazid groups were decreased.Conclusion The CpG island in the promoter of GSTP1 has hypomethylation in hepatocyte cells damaged by isoniazid.

7.
Journal of Practical Radiology ; (12): 204-207, 2016.
Article in Chinese | WPRIM | ID: wpr-485783

ABSTRACT

Objective To explore the value of the spectral CT iodine-based material decomposition technique in differential diagnosis of central pulmonary carcinoma from obstructive pneumonia and atelectasis.Methods 25 cases with central pulmonary carcinoma complicating with obstructive pneumonia and atelectasis underwent CT plain scan and spectral contrast scan including pulmonary-arterial-phase (PAP) and bronchial-arterial-phase(BAP).Conventional CT images and iodine base images were generated in each phase by GSI viewer.The 4 groups of images differences between the tumor and the obstructive pneumonia and atelectasis were analyzed.Results The margin of the tumor was ill-defined in plain scan.The cases that showed difference between the tumor and the obstructive pneumonia and atelectasis in 4 groups of images were respectively as follows,10 in conventional CT images of PAP,1 6 in conventional CT images of BAP,1 9 in iodine base images of PAP,and 23 in iodine base images of BAP.The difference of the 4 groups was significant (χ2 =16.54,P0.05),but were better than that of the conventional CT images of PAP(χ2 =6.65,P <0.05).Conclusion Spectral CT iodine-based material decomposition technique is helpful to improve subjective diagnosis of central pulmonary carcinoma complicating with obstructive pneumonia and atelectasis,especially in iodine base images of BAP,it can provide accurate information for clinical stage and treatment.

8.
Journal of Practical Radiology ; (12): 1285-1288, 2016.
Article in Chinese | WPRIM | ID: wpr-495954

ABSTRACT

Objective To explore the application of low dose of radiation combined with low concentration of contrast medium in the energy spectrum CT of the coronary artery angiography.Methods 60 patients with suspected diagnosis of coronary heart disease were randomly divided into A,B two groups,30 cases in each group.Group A with 350 mg I/mL contrast agent,undergoing conventional CT scanning;Group B using 300 mg I/mL contrast agent,the gems energy spectrum CT scanning with low-dose.Two groups both adopted forward-looking heart switch control scanning mode.After scanning,group A reconstructed conventional images of 40% ASiR sequence,group B rebuilded axial surface images of single energy 65 keV and 40% ASiR sequence,all the reconstruction images were introduced to AW4.6 workstations used for analysis.Double-blind subjective rating was done by two experienced doctors to measure CT values and SD of aortic sinus (AS),left main (LMA),the left anterior descending branch proximal (LAD-p),left circumflex branch proximal (LCX-p), right coronary artery proximal (RCA-p)and pericardial fat,AS the noise (SD),to calculate the signal-to-noise ratio (SNR)and contrast to noise ratio (CNR),to calculate the effective doses of radiation(ED)by recording CTDI and DLP,and to record iodine intake.By using two independent samples t test to compare two groups of patients’the effective radiation doses,iodine intake,the average CT value,SD,SNR and CNR.Results The subjective image quality score differences and coronary measuring section CT values between the two groups had no statistical significance.In the aspects of effective radiation dose,group B reduced about 29% compared to group A,the difference was statistically significant.Iodine intake in group B decreased about 16% than in group A.Conclusion In coronary artery CT imaging, spectral scanning with low dose of radiation and reconstruction images with single energy can effectively reduce the radiation dose and iodine intake,at the same time it can obtain the approximate image quality like conventional scanning.

9.
Chinese Journal of Medical Imaging ; (12): 955-958,960, 2015.
Article in Chinese | WPRIM | ID: wpr-603637

ABSTRACT

PurposeTo explore the feasibility of personalized energy spectrum scanning in upper abdomen CT by comparing the image quality and radiation dose of optimizing choice spectrum scanning protocol with conventional 120 kVp scan.Material and Methods Sixty patients undergoing abdominal CT scan with and without contrast enhancement were prospectively collected and randomly assigned into two groups. Group A (30 patients) underwent conventional 120 kVp scan and spectral enhancement scanning; group B (30 patients) underwent spectrum scan and 120 kVp enhancement scanning. Spectral scanning protocol was based on individual choice with conventional 120 kVp NI10-5 mm average mAs scan for every patient. The CT dose index of volume (CTDIvol) and effective dose (ED) during non-contrast phase and portal venous phase were recorded. The CT value, standard deviation (SD), signal noise ratio (SNR) and contrast noise ratio (CNR) were measured in the liver parenchyma, spleen parenchyma and portal venous trunk.Results The CTDIvol and ED of spectrum scanning were less than 120 kVp scan but there was no statistical difference (P>0.05). The SD of group B GSI imaging was less than group A 120 kVp (P<0.05), while the SNR was greater than group A. The SD of group A GSI portal venous phase in the liver, spleen and portal vein was less than group B 120 kVp (P<0.05).ConclusionThe optimized energy spectrum scanning protocol can reduce radiation dose with quality of single energy image from the energy spectrum equal to or better than the conventional 120 kVp scanning protocol. Personalized energy spectrum scan protocol provides multi-parameter diagnosis and multi-application platform and can be used routinely in the upper abdomen scan.

10.
Article in Chinese | WPRIM | ID: wpr-600927

ABSTRACT

Objective To study the influence of prothrombin complex concentrates (PCC) containing different levels of antithrombin (AT) and heparin on its procoagulation and anticoagulation activities.Methods PCC containing traces of heparin and AT were prepared.The design of orthogonal experiment: set AT and heparin two variable factors, each factor respectively from three levels: 0, 0.4, 0.8 IU/mL; 0, 2.5, 5.0 IU/mL.Their influence on the procoagulation and anticoagulation activities of PCC were analysed.Results The R value of the influence of AT on thrombin inhibitory capacities was higher than that of heparin.With the increase of AT level, time to peak gradually extended.Lag time of 0.4 IU/mL and 0.8 IU/mL AT was the same.The peak height of 0.4 IU/mL AT was highest.The higher the level of AT, the greater the impact on thrombin inhibitory capacities.0.4 IU/mL and 0.8 IU/mL AT had similar impact on thrombin inhibitory capacities.The R values of the influence of heparin on thrombin generation were higher than that of AT.With the increase of heparin level, lag time and time to peak were longer while the peak height declined sharply.0 IU/mL and 2.5 IU/mL heparin had similar influence on thrombin generation.The higher the level of heparin, the greater influence on thrombin inhibitory capacities.2.5 IU/mL and 5.0 IU/mL heparin had similar influence on thrombin inhibitory capacities.Conclusion AT has greater influence on the anticoagulation activities of PCC than that of heparin, while heparin has greater influence on the procoagulation activities of PCC than that of AT.PCC containing medium levels of AT and heparin is relatively balanced between procoagulation and anticoagulation.

11.
Article in Chinese | WPRIM | ID: wpr-476308

ABSTRACT

BACKGROUND:Titanium aloy and stainless steel are two common internal fixation materials, but there are some difference in their therapeutic effects and biocompatibility. OBJECTIVE:To explore the therapeutic effects and biocompatibility of titanium aloy and stainless steel internal fixation materials for the treatment of spinal tuberculosis. METHODS:Seventy-one spinal tuberculosis patients, 35 males and 36 females, aged 17-81 were enroled. Among them, 35 patients received titanium aloy internal fixation, and the 36 patients underwent stainless steel internal fixation. At the end of 12-month folow-up, Cobb angle changes, therapeutic effect and Frankel grade were analyzed in the two groups. RESULTS AND CONCLUSION:Before treatment, there was no difference in the spinal kyphosis angle and Frankel grade between the two groups. At the last folow-up, the Frankel grade and Cobb angle were both improved in the two groups (P < 0.05), but there was stil no difference between the two groups. The cure rate was 97% (n=34) in the titanium aloy group and 92% in the stainless steel group (n=33), and no significant difference was found between the two groups. These two kinds of internal fixation materials exhibited good biocompatibility, and no infection and other adverse reactions occurred. These findings indicate that both titanium aloy and stainless steel as internal fixation materials have good biocompatibility and therapeutic effects.

12.
Journal of Practical Radiology ; (12): 1100-1103, 2015.
Article in Chinese | WPRIM | ID: wpr-461317

ABSTRACT

Objective To compare the virtual non-enhanced chest CT (VNCT)generated from spectral CT with conventional non-enhanced chest CT in patients with lung disease in terms of CT number accuracy and image quality.Methods A total of 30 patients with lung disease proved by pathology underwent the conventional non-enhanced thoracic CT and contrast enhanced CT with spectral imaging mode in arterial phase (AP)and venous phase (VP).The VNCT images were reconstructed based on the enhanced spectral CT imaging data.The mean CT number,signal to noise ratio (SNR)for the lesions and image quality score were obtained and compared between the true non-contrast CT (TNCT)and the VNCT (including AP and VP)with paired t test.Results The mean±standard deviation for CT number were (38.74±5.17)HU,(39.08±5.07)HU and (38.96± 5.18)HU for TNCT,VNCT at AP and VNCT at VP,respectively, with no statistical difference (P>0.05).All 3 sets of images demonstrated acceptable image quality,even though there were statistically significant differences in the SNR value and image quality score.The mean ± standard deviation values for SNR were 4.74±0.42 with TNCT, 3.79 ± 0.5 1 with VNCT at AP and 3.77 ± 0.39 with VNCT at VP (P <0.05),and the image quality scores were 5.00 ±0.00 with TNCT,4.17±0.65 with VNCT at AP and 4.17±0.53 with VNCT at VP (P<0.05).Conclusion In patients with lung disease,the vir-tual non-enhanced CT images generated from spectral CT provide accurate CT numbers for lesions and acceptable image quality com-pared with the true non-contrast CT.VNCT may be used to replace TNCT to improve work flow and reduce radiation dose.

13.
Journal of Practical Radiology ; (12): 1018-1021, 2015.
Article in Chinese | WPRIM | ID: wpr-459703

ABSTRACT

Objective To evaluate the clinical value of spectral CT monochromatic imaging in improvement of imaging quality of bronchial arteries.Methods We retrospevtively analyzed the chest CT images in 38 patients who underwent the contrast-enhanced spectral CT.These images included a set of 140 kVp polychromatic images and default 70 keV monochromatic images.Using a standard Gemstone Spectral Imaging (GSI)viewer at an advanced workstation (AW4.6),an optimal energy level (in keV)for obtai-ning the best CNR of the bronchial artery could be automatically obtained.The SNR,CNR and objective imaging quality score for these 3 imaging sets (140 kVp,70 keV and optimal energy level)were obtained and compared with one-way ANOVA .Results The optimal energy levels for obtaining the best CNR were (62.58±2.74)keV.The SNR of the 140 kVp polychromatic images,70 keV monochromatic images,and the optimal keV monochromatic images were 1 6.44±5.85,20.96 ±8.32 and 24.91 ±9.91,the CNR were 13.30±5.45,1 7.25±6.97 and 20.67±8.62,and the subjective imaging quality scores were 1.97 ±0.82,3.24±0.75 and 4.47±0.60,respectively,exhibiting significant differences among groups (F =10.1 7,10.1 7 and 1 1 1.12,P <0.00).The optimal monochromatic group was superior to the 70 keV group and the 140 kVp mixed-energy group.Conclusion Monochromatic images at approximately 62 keV in dual-energy spectral CTA yields the best CNR and highest diagnostic confidence for imaging bronchial ar-teries,which may improve imaging quality for imaging bronchial arteries.

14.
Article in English | WPRIM | ID: wpr-267208

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effects of electroacupuncture (EA) of different intensities on lactate dehydrogernase (LDH), succinate dehydrogenase (SDH) and ATPase in brain tissue of rats with cerebral ischemia-reperfusion injury (CI/R).</p><p><b>METHODS</b>Forty male SD rats were uniformly randomized into sham operation group (group A), CI/R group (group B), CI/R+5 mA EA (group C), CI/R+3 mA EA (group D) and CI/R+1 mA EA (group E) groups with eight rats in each group. Transient general brain ischemia was induced by four-vessel occlusion and reperfusion. The rats in group C, group D and group E were punctured and stimulated at Baihui (GV20), Mingmen (GV4) and Zusanli (ST36) with the same intermittent and rarefaction-dense wave (30 to 50 Hz) and different electric current intensities: 5 mA, 3 mA and 1 mA for 20 min after CI/R. Then the activities of Na(+)-K(+)-ATPase, SDH and LDH in mitochondria of brain tissue were measured by spectrophotometry. The ischemic cerebral cortex tissue was taken for observing the ultrastructure changes of impaired nerve cells.</p><p><b>RESULTS</b>Compared with group A, the activities of LDH, SDH and Na(+)-K(+)-ATPase were lowerer in the group B (P<0.05 or P<0.01). However, the activities of LDH, SDH and Na(+)-K(+)-ATPase were higher in the group D than those in the group B (P<0.05 orP<0.01). In group A, the anatomical structure of the cerebral cortex cells was basically normal; in group B, the neuronal cellular structures were severely damaged, the neuronal mitochondria got swelling, the mitochondrial cristae were broken, the medullated nerve fifibers were not integrated. In group C, group D and group E, the ultrastructure of impaired neuron were improved. Group D was the best among three groups above.</p><p><b>CONCLUSION</b>EA of 3 mA intensity could strengthen aerobic metabolism by elevating the activities of SDH and LDH, meanwhile maintaining the ionic equilibrium in the exterior and interior brain cell and relieving the cellular edema by reinforcing the activities of Na(+)-K(+)-ATPase.</p>


Subject(s)
Animals , Brain , Metabolism , Electroacupuncture , Energy Metabolism , Male , Mitochondria , Metabolism , Rats , Rats, Sprague-Dawley , Reperfusion Injury , Metabolism
15.
Article in Chinese | WPRIM | ID: wpr-454419

ABSTRACT

Objective To investigate the differences in the attitudes toward physician-nurse collaboration among undergraduate nurses and physicians,and provide evidence for creating good physiciannurse atmosphere of cooperation.Methods The Jefferson Scale of Attitudes toward Physician-Nurse Collaboration (JSAPNC) was administered to 96 undergraduate nurses and 52 physicians in admitting department.Results The participants' score of JSAPNC were relatively high,especially on the items Caring as opposed to curing and Nurse autonomy.The score of undergraduate nurses was lower than physicians on the item there are a lot of overlap responsibilities between nurses and physicians ;the score of undergraduate nurses was higher than physicians on the item physician authority.Conclusions Undergraduate nurses and physicians have a positive attitude toward physician-nurse collaboration.Nurses believe that some of their duties are common during their work,but the communication was not ideal.The overall health care rounds should include physicians and nurses,which can increase the communication,strengthen the spirit of collaboration and create good physician-nurse atmosphere.

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