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1.
Article in Chinese | WPRIM | ID: wpr-751038

ABSTRACT

Objective @#To compare the shaping ability of 3 different nickel (Ni)-titanium (Ti) systems in simulated root canals in resin and to provide a reference for clinicians.@*Methods@#Forty-eight resin blocks were prepared using the F360 (Komet, Brasseler GmbH & Co., Lemgo, Germany) (Group 1), F6 SkyTaper (20/06) (Komet, Brasseler GmbH & Co., Lemgo, Germany) (Group 2), F6 SkyTaper (25/06) (Komet, Brasseler GmbH & Co., Lemgo, Germany) (Group 3) and Reciproc R25 systems (VDW, Munich, Germany) (Group 4) (n=12 canals/group). The images taken before and after preparation were superimposed and analyzed by Adobe Photoshop v7.0. The amount of resin removed by each system was measured, and the centering ability was assessed. The data were statistically analyzed using SPSS 20.0.@*Results @#At the 1 mm point, the transportation in Group 4 [(0.10 ± 0.03) mm] was significantly greater than that in Groups 2 [(0.05 ± 0.03) mm] and 3 [(0.05 ± 0.03) mm] (P < 0.05). At the 8 mm and 9 mm points, the transportation values in Group 4 [(0.12 ± 0.06) mm and (0.13 ± 0.05) mm] were significantly higher than those in Groups 2 [(0.05 ± 0.05) mm and (0.05 ± 0.05) mm] and 3 [(0.05 ± 0.04) mm and (0.06 ± 0.05) mm] (P < 0.05). At the 10 mm point, the transportation was significantly greater in Group 4 [(0.13 ± 0.06) mm] than in Group 2 [(0.06 ± 0.06) mm].@*Conclusion@#F6 SkyTaper exhibits better centering ability than Reciproc.

2.
Chinese Journal of School Health ; (12): 676-679, 2019.
Article in Chinese | WPRIM | ID: wpr-818691

ABSTRACT

Objective@#To investigate the relationship between after-school schedule and bone mineral density in middle-school students in Shanghai, to provide a reference for taking targeted measures.@*Methods@#From November 2017 to April 2018,eighteen classes of six middle schools in Shanghai (from urban districts, urban-suburb combined districts and suburban districts, respectively) were selected based on cluster random sampling. In each school, 2-4 classes were further randomly chosen in the 6th grade. Questionnaires were completed by 518 students and their parents, as well as physical examination and bone mineral density assessment.@*Results@#The average time spent on after-school academic learning during weekends was 4.0 (IQR: 2.0, 6.0) h. The Z-score of bone density was 0.3 (IQR: -0.7, 1.0). The smooth curve fit model showed a non-linear relationship between after-school academic learning time during weekends and the Z-scores of bone mineral densities. A two-stage multiple linear regression analysis was further applied according to the fit results, and the results showed that when total afterschool academic learning time <4.5 hours during weekends, the learning time was inversely correlated with the bone density Z-scores (β=-0.11,P=0.01), and when the learning time ≥4.5 hours, there was no significant correlation between the learning time and bone density Z-scores (β=0.02, P=0.65). Parent and student questionnaires showed that there was a non-linear relationship between students’ daily time spent on outdoor sports-related activities and bone density Z-scores. When time spent on the outdoor activities ≥45 minutes per day, outdoor activities were positively correlated with bone density Z-scores (P<0.05). However, when the time spent on outdoor activities <45 minutes per day, there was no significant relationship between outdoor activities and bone density Z-scores (P>0.05).@*Conclusion@#Too much time on after-school academic learning during weekends or limited time on outdoor activities are both related to impaired bone mineral densities. Therefore, a reasonable after-school schedule for middle-school students is important for physical development, especially during weekends.

3.
Pakistan Journal of Medical Sciences. 2013; 29 (3): 762-767
in English | IMEMR | ID: emr-127336

ABSTRACT

Polymorphisms in XPG were considered to contribute to the clinical outcome of patients receiving platinum drug chemotherapy. We investigated the impact of several potential SNPs of XPG on the efficacy of platinum-based chemotherapy in NSCLC patients. A total of 433 patients were consecutively selected between Nov. 2006 and Dec. 2007, and were followed-up up to Nov. 2011. The genotyping of six SNPs [rs2296147, rs751402, rs873601, rs4150375, rs17655 and rs2094258] were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. Patients carrying CT+TT genotype of rs2296147 had a significantly longer median PFS [17.5 months] and OS [26.8 months] than CC genotype. Hazard ratio [HR] for PFS and OS in patients with CT+TT genotype of rs2296147 was respectively 0.73[0.51-0.97] and 0.66[0.48-0.99] when compare CC genotype, respectively. Similarly, patients with rs2094258 AG+GG genotype had a longer median progression time [18.4 months] and overall survival time [27.3 months] when compared with those with AA genotype, and HRs[95% CI] for PFS and OS were 0.44[0.34-0.78] and 0.51[0.39-0.82], respectively. Our study suggests rs2296147 CT+TT and rs2094258 AG+GG genotypes contribute to the better survival of NSCLC. Our study provides significant information on role of prognostic value of XPG SNPs, and detecting of XPG could be used as predictive markers toward individualizing NSCLC treatment strategies


Subject(s)
Humans , Female , Male , Carcinoma, Non-Small-Cell Lung/mortality , Lung Neoplasms , Xeroderma Pigmentosum , Polymorphism, Single Nucleotide , Survival Rate , Disease-Free Survival , Biomarkers
4.
Article in Chinese | WPRIM | ID: wpr-349789

ABSTRACT

The factors influencing the long-term survival of patients with proximal gastric cancer(PGC)after curative resection were investigated.Data from 171 patients who underwent curative resection for PGC were retrospectively analyzed.The patients were grouped according to the clinicopathological factors and operative procedures.The tumor depth(T stage)and lymph node metastasis(pN stage)were graded according to the fifth edition of TNM Staging System published by UICC in1997.The metastatic lymph node ratio(MLR)was divided into four levels: 0%,<10%,10%-30%and >30%.The data of survival rate were analyzed by Kaplan-Meier method(log-rank test)and Cox regression model.The 5-year overall survival rate of 171 patients was 37.32%.The univariate analysis demonstrated that the survival time of the postoperative patients with PGC was related to tumor size(;(2=4.57,P=-0.0325),gross type(χ2=21.38,P<0.001),T stage(χ2=27.91,P<0.001),pN stage(χ2=44.72,P<0.001),MLR(χ2=61.12,P<0.001),TNM stage(χ2=44.91,P<0.001),and range of gastrectomy (χ2=4.36,P=0.0368).Multivariate analysis showed that MLR(χ2=10.972,P=0.001),pN stage(χ2=6.640,P=0.010),TNM stage(χ2=7.081,P=0.007),T stage(χ2=7.687,P=0.006)and gross type(χ2=6.252,P=0.012)were the independent prognostic factors.In addition,the prognosis of patients who underwent total gastrectomy(TG)was superior to that of patients who underwent proximal gastrectomy(PG)for the cases of tumor ≥5 cm(χ2=6.31,P=0.0120),Borrmann Ⅲ/Ⅳ(χ2=7.96,P=0.0050),T4(χ2=4.57,P=0.0325),pN2(χ2=5.52,P=0.0188),MLR 10%-30%(χ2=4.46,P=0.0347),MLR >30%(χ2=13.34,P=0.0003),TNM Ⅲ(χ2=14.05,P=0.0002)or TNM Ⅳ stage(χ2=4.37,P=0.0366);and combining splenectomy was beneficial to the cases of T3(χ2=5.68,P=0.0171)or MLR >30%(χ2=6.11,P=0.0134).It was concluded that MLR,pN stage,TNM stage,T stage,and gross type had advantages in providing a precise prognostic evaluation for patients undergoing curative resection for PGC,in which MLR was the most valuable index.TG and combining splenectomy were useful to improve the prognosis to patients with PGC of TNM Ⅲ/Ⅳ stage,serosa invasion,or extensive regional lymph node metastasis.

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