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An. acad. bras. ciênc ; 89(3,supl): 2141-2154, 2017. tab, graf
Article in English | LILACS | ID: biblio-886785


ABSTRACT The purpose of this study was to evaluate the antiproliferative and antigenotoxic activity of Sambucus australis Cham. & Schltdl. aqueous extracts on the cell cycle of Allium cepa L. as well as determine the phenolic compounds in such extracts. S. australis inflorescences and leaves of two accessions were used for aqueous extract preparation at concentrations: 0.003 g/ml and 0.012 g/ml. A. cepa bulbs were rooted in distilled water and, subsequently, placed in treatments for 24 hours. Rootlets were collected and fixed in modified Carnoy's solution for 24 hours and kept. The squash technique was performed for slide preparation. Root tips were smashed and stained with 2% acetic orcein, and a total of 4000 cells per treatment were analyzed. The phenolic compounds were determined using high-performance liquid chromatography and data was analyzed using the Scott-Knott test. The results show that S. australis aqueous extracts have antiproliferative potential. Besides, the extracts prepared from S. australis leaves of both accessions at a concentration of 0.012 g/ml have shown antigenotoxic activity. The phytochemical analysis allowed us to determine the presence of flavonoids and phenolic acids, of which kaempferol and chrologenic acid were the most predominant compounds in the extracts from the inflorescences and leaves, respectively.

Flavonoids/chemistry , Plant Extracts/chemistry , Plant Leaves/chemistry , Sambucus/chemistry , Adoxaceae/chemistry , Phenols/analysis , Water/analysis , Plant Extracts/pharmacology , Phytochemicals/analysis , Antioxidants/analysis , Antioxidants/pharmacology
Braz. j. phys. ther. (Impr.) ; 18(2): 144-151, 16/05/2014. tab, graf
Article in English | LILACS | ID: lil-709553


Objectives: To investigate whether the muscle strength decrease that follows anterior cruciate ligament (ACL) reconstruction would lead to different cardiorespiratory adjustments during dynamic exercise. Method: Eighteen active male subjects were submitted to isokinetic evaluation of knee flexor and extensor muscles four months after ACL surgery. Thigh circumference was also measured and an incremental unilateral cardiopulmonary exercise test was performed separately for both involved and uninvolved lower limbs in order to compare heart rate, oxygen consumption, minute ventilation, and ventilatory pattern (breath rate, tidal volume, inspiratory time, expiratory time, tidal volume/inspiratory time) at three different workloads (moderate, anaerobic threshold, and maximal). Results: There was a significant difference between isokinetic extensor peak torque measured in the involved (116.5±29.1 Nm) and uninvolved (220.8±40.4 Nm) limbs, p=0.000. Isokinetic flexor peak torque was also lower in the involved limb than in the uninvolved limb (107.8±15.4 and 132.5±26.3 Nm, p=0.004, respectively). Lower values were also found in involved thigh circumference as compared with uninvolved limb (46.9±4.3 and 48.5±3.9 cm, p=0.005, respectively). No differences were found between the lower limbs in any of the variables of the incremental cardiopulmonary tests at all exercise intensities. Conclusions: Our findings indicate that, four months after ACL surgery, there is a significant deficit in isokinetic strength in the involved limb, but these differences in muscle strength requirement do not produce differences in the cardiorespiratory adjustments to exercise. Based on the hypotheses from the literature which explain the differences in the physiological responses to exercise for different muscle masses, we can deduce that, after 4 months of a rehabilitation program after an ACL reconstruction, individuals probably ...

Adult , Humans , Male , Anterior Cruciate Ligament Reconstruction , Exercise Test , Muscle Strength , Heart/physiology , Leg/physiology , Metabolism , Respiration
Braz. j. phys. ther. (Impr.) ; 17(6): 572-578, dez. 2013. tab
Article in English | LILACS | ID: lil-696986


BACKGROUND: Data obtained on an isokinetic dynamometer are useful to characterize muscle status and have been reported in muscle imbalance studies in different types of sport. However, few studies have assessed elite handball players to establish reference values. OBJECTIVE: The purpose of this study was to compare, for the dominant (D) and non-dominant (ND) side, the isokinetic profile of shoulder rotator muscle strength between male handball players (H) and asymptomatic non-athletes (NA). METHOD: Isokinetic concentric and eccentric strength tests for D upper limbs were performed by the H group (n=20) and the NA group (n=12). Internal and external rotator muscle peak torque in concentric action was assessed at 60°/s and 300°/s and in eccentric action at 300°/s. We also calculated conventional balance (the ratio of external rotator peak torque to internal rotator peak torque in concentric action) and functional balance (the ratio of external rotator peak torque in eccentric action to internal rotator peak torque in concentric action). RESULTS: In the H group, dominant limbs were stronger in concentric action for external rotation at 60 and 300°/s. The conventional balance ratio for the D side was significantly lower at 60 and 300°/s for H compared to NA. The functional ratio for the D side was significantly lower at 300º/s for H compared to NA. CONCLUSIONS: Compared to asymptomatic non-athletes, handball players presented significant muscular imbalance resulting from daily sports practice, a known risk factor for shoulder injuries. .

Adult , Humans , Male , Range of Motion, Articular , Shoulder Joint/physiology , Sports/physiology , Biomechanical Phenomena , Brazil
Braz. j. phys. ther. (Impr.) ; 14(4): 316-321, jul.-ago. 2010. tab
Article in Portuguese | LILACS | ID: lil-560703


OBJETIVOS: Determinar a relação potência-duração em exercícios de membros superiores (MMSS) e verificar a relação dos parâmetros derivados dessa função com indicadores fisiológicos de aptidão aeróbia. Métodos: Dez homens saudáveis (26,2±2,3 anos, 75,0±11,8 kg, 178,2±11,5 cm e 15,0±5,7 por cento de gordura) realizaram um teste de rampa em cicloergômetro de braço com incrementos de 20 W/min. Posteriormente, cinco testes de carga constante até a exaustão a 70, 80, 90, 95 e 100 por cento da diferença entre LV1 e o VO2pico foram realizados. A potência crítica (PC) foi obtida por meio da linearização da função potência-duração. RESULTADOS: A relação potência-duração foi descrita pela função ajustada (r=0,98±0,02). O VO2 na PC (2,66±0,62 l/min) foi maior do que no LV1 (1,62±0,38 l/min) e LV2 (2,36±0,59 l/min, respectivamente), mas menor do que o VO2pico (3,06±0,62 l/min). A carga da PC (103,0±26,0 W) foi diferente da encontrada em LV1 (69,5±21 W) e VO2pico (151,0±26,3 W), mas não da em LV2 (103,5±30,8 W). A associação entre a PC e esses indicadores de aptidão aeróbia foram todas significantes quando expressas em VO2 (0,73 a 0,78; p<0,05) e em W (0,83 a 0,91; p<0,05). A determinação da PC em exercícios dinâmicos de MMSS é simples e de baixo custo, podendo ser utilizada pelo fisioterapeuta na prescrição e avaliação do treinamento de MMSS. CONCLUSÃO: A relação potência-duração em exercícios com os MMSS pode ser descrita por uma função hiperbólica e está associada a indicadores fisiológicos da aptidão aeróbia.

OBJECTIVES: To determine the power-duration relationship in upper limb exercises and to investigate the relationships between parameters derived from this function with physiological indicators of aerobic fitness. METHODS: Ten healthy men (26.2±2.3 years, 75.0±11.8 kg, 178.2±11.5 cm and 15.0±5.7 percent body fat) performed a ramped test on an arm cycle ergometer with increments of 20 W/min. Subsequently, five tests with constant load were performed until exhaustion, with 70, 80, 90, 95 and 100 percent difference between VT1 and VO2peak. The critical power (CP) was obtained by means of linearization of the power-duration function. RESULTS: The power-duration relationship was described using an adjusted function (r=0.98±0.02). The VO2 at CP (2.66±0.62 l/min) was higher than VT1 (1.62±0.38 l/min) and VT2 (2.36±0.59 l/min), but lower than VO2peak (3.06±0.62 l/min). The CP workload (103.0±26 W) was significantly different from VT1 (69.5±21 W) and VO2peak workloads (151.0±26.3), but was no different of VT2 (103.5±30.8 W). The association between critical power and aerobic condition indexes were always significant when expressed as VO2 (0.73 to 0.78, p<0.05) and in W (0.83 to 0.91, p<0.05). Determination of CP in upper-limb dynamic exercises is simple and inexpensive, and can be used by physical therapists for prescribing and evaluating upper-limb training programs. CONCLUSIONS: The power-duration relationship in upper-limb exercises can be described by a hyperbolic function and it is associated with physiological indicators of aerobic fitness.

Adult , Humans , Male , Young Adult , Arm/physiology , Exercise/physiology , Physical Endurance/physiology , Time Factors , Young Adult
Arq. bras. endocrinol. metab ; 54(6): 550-554, ago. 2010. ilus, tab
Article in English | LILACS | ID: lil-557851


OBJECTIVE: The aim of this study was to evaluate the accuracy of the measurement of thyroglobulin in washout needle aspiration biopsy (FNAB-Tg) to detect papillary thyroid cancer (PTC) metastases. SUBJECTS AND METHODS: Forty-three patients (51.4 ± 14.6 years) with PTC diagnosis and evidence of enlarged cervical lymph nodes (LN) were included. An ultrasound-guided fine-needle aspiration of suspicious LN was performed, for both cytological examination and measurement of FNAB-Tg. RESULTS: The median values of FNAB-Tg in patients with metastatic LN (n = 5) was 3,419 ng/mL (11.1-25,538), while patients without LN metastasis (n = 38) showed levels of 3.7 ng/mL (0.8-7.4). Considering a 10 ng/mL cutoff value for FNAB-Tg, the sensitivity and specificity was 100 percent. There were no differences on the median of FNAB-Tg measurements between those on (TSH 0.07 mUI/mL) or off levothyroxine (TSH 97.4 mUI/mL) therapy (3.3 vs. 3.8 ng/mL, respectively; P = 0.2). CONCLUSION: The results show that evaluation of FNAB-Tg in cervical LN is a valuable diagnostic tool for PTC metastases that can be used independent of the thyroid status.

OBJETIVO: O objetivo deste estudo foi avaliar a acurácia da dosagem de tireoglobulina no lavado da agulha da punção aspirativa (PAAF-Tg) de linfonodos (LN) cervicais para detecção de metástases do câncer papilar de tireoide (CPT). SUJEITOS E MÉTODOS: Foram incluídos 43 pacientes (51,4 ± 14,6 anos) com diagnóstico de CPT e evidência de LN cervicais aumentados. Os LN suspeitos foram submetidos à punção aspiração com agulha fina guiada por ecografia para análise citológica e dosagem de tireoglobulina (PAAF-Tg). RESULTADOS: A mediana dos valores de PAAF-Tg nos LN metastáticos (n = 5) foi 3.419,0 ng/mL (11,1-25.538), enquanto nos LN não metastáticos (n= 38) a mediana foi de 3,7 ng/mL (0,8-7,4). Utilizando-se o nível de 10 ng/mL como ponto de corte, observaram-se sensibilidade e especificidade de 100 por cento. Os níveis de TSH sérico não interferiram na dosagem de PAAF-Tg (3,3 e 3,8 ng/mL nos grupos com TSH supresso (TSH 0,07 mUI/mL) e hipotireoidismo (TSH 97,4 mUI/mL), respectivamente, P = 0,2). CONCLUSÃO: Os resultados demonstram que a dosagem de PAAF-Tg é uma ferramenta importante no diagnóstico de metástases do CPT, podendo ser utilizada independente do "status" tireoidiano.

Adult , Aged , Female , Humans , Male , Middle Aged , Biopsy, Fine-Needle/methods , Carcinoma, Papillary/diagnosis , Lymph Nodes/chemistry , Thyroglobulin/analysis , Thyroid Neoplasms/diagnosis , Biomarkers, Tumor/analysis , Carcinoma, Papillary/secondary , Lymph Nodes/pathology , Lymphatic Metastasis/diagnosis , Neck , Sensitivity and Specificity , Thyroid Neoplasms/secondary , Thyrotropin/physiology
J. epilepsy clin. neurophysiol ; 13(3): 131-136, Sept. 2007. tab
Article in Portuguese | LILACS | ID: lil-471130


INTRODUÇÃO: Pessoas com epilepsia tem sido constantemente desaconselhadas a participarem de atividades físicas ou esportivas por receio do exercício provocar crises epilépticas. Apesar da atitude médica atual recomendando a participação em atividades esportivas, o estigma ainda persiste e as pessoas com epilepsia continuam menos ativas que a população em geral. OBJETIVOS: Neste sentido, vários estudos clínicos e experimentais têm demonstrado um efeito benéfico do exercício físico na epilepsia. O judô é um esporte tradicional e popular e pessoas com epilepsia freqüentemente perguntam aos médicos se podem participar deste tipo de esporte. CONCLUSÃO: Baseado nestas questões, este artigo de revisão propõe avaliar os riscos e benefícios da atividade física em pessoas com epilepsia e discutir o papel do judô neste contexto.

INTRODUCTION: Persons with epilepsy have previously been discouraged from participation in physical activity and sports for fear of inducing seizures or increasing seizure frequency. Despite a shift in medical recommendations toward encouraging rather than restricting participation, the stigma remains and persons with epilepsy continue to be less active than the general population. OBJECTIVES: In these lines, several clinical and experimental studies have demonstrated a positive effect of physical exercise on epilepsy. Judo is a traditional and popular sport and people with epilepsy often ask physicians whether they may engage in this sport. CONCLUSIONS: Based on this, our review article is designed to show the risks and benefits of physical activity in patients with epilepsy and discusses the role of judo in this context.

Humans , Seizures/surgery , Martial Arts , Epilepsy/therapy , Motor Activity
Rev. Clín. Ortod. Dent. Press ; 6(4): 42-49, ago.-set. 2007. ilus, tab
Article in Portuguese | LILACS, BBO | ID: biblio-856195


Objetivou-se neste trabalho realizar uma revisão de literatura sobre o processo de soldagem em Ortodontia, pelo fato do mesmo só ser conhecido sob um enfoque empírico. A técnica de soldagem é universalmente aceita e de resultados clinicamente eficazes. Descreveu-se não somente a técnica em si, mas também o comportamento de todos os componentes qua a interagem durante o procedimento de soldagem, incluindo alterações atômicas, mecânicas e físicas. Abordou-se o processo de soldagem a ouro por ter sido o percursor em Ortodontia de todas as outras técnicas envolvendo solda, além de demandar grande habilidade manual, por ser um procedimento de extrema complexidade de execução. Comparou-se também tais procedimentos com a soldagem autógena, avaliando-se vantagens e desvantagens clínicas de seu emprego. Não foram observadas alterações significativas nas características físico-estruturais dos elementos a serem soldados heteroginamente, não havendo assim, nenhuma desvantagem relevante em relação à soldagem autógena

Gold , Metallurgy , Silver , Dental Soldering/methods
Rev. bras. farmacogn ; 17(1): 49-54, jan.-mar. 2007. tab
Article in Portuguese | LILACS | ID: lil-451564


Achyrocline satureioides (marcela) é utilizada na medicina popular brasileira, na forma de chá, como tratamento de patologias digestivas e inflamatórias. O efeito anti-proliferativo de infusões de marcela sobre o ciclo celular da cebola foi avaliado, utilizando-se inflorescências de marcela recém coletadas (2005) e após armazenamento por 30 meses (2003). Preparou-se as infusões em duas concentrações: 5,0 mg/mL (concentração usual como chá) e 20 mg/mL. Utilizaram-se 3 grupos de 6 bulbos de cebola para cada população de marcela. Retirou-se um grupo de bulbos controle de cada população. Todos os bulbos enraizados em água destilada foram transferidos para os extratos de marcela e permaneceram por 24 horas, (os bulbos controle permaneceram em água). As radículas foram coletadas, fixadas em etanol-ácido acético (3:1) por 24 h e estocadas em álcool 70 por cento. Foram analisadas 6000 células por grupo de bulbos, e os índices mitóticos calculados submetidos a análise estatística pelo teste chi2 a 5 por cento. Conclui-se que as infusões de marcela possuem ação antiproliferativa sobre o ciclo celular da cebola e que essa ação inibitória da divisão celular aumenta conforme aumento da concentração, bem como após o armazenamento.

Achyrocline saturoides (marcela) is used in Brazilian folk medicine as a tea in the treatment of digestive and inflammatory diseases. The anti-proliferative effect of infusions of marcela on onion cell cycle was evaluated by using the inflorescences of recently collected marcela and after the storage for 30 months. Marcela inflorescences were collected for the infusion preparations in 2003 and in 2005 (used still fresh). We prepared the infusions at two concentrations 5.0 mg/mL (concentration used as tea) and 20 mg/mL. We used two groups of six onion bulbs for each population of marcela, and one group of bulbs of each population was withdrawn as a control group. All bulbs rooted in distilled water and after they were transferred to the extracts of marcela and they were kept there for 24 hours (control bulbs remained under water). The root tips were collected, after fixed in ethanol acetic acid (3:1) for 24 hours and, stored under alcohol 70 percent. A total of 6000 cells per group of bulbs was analyzed, and the mitotic indexes were calculated and undergone to statistical analysis by using chi2 at 5 percent. The conclusions were that the infusions of marcela have anti-proliferative action on the cell cycle of onion and that this inhibitory action on the cell division increases according to the increase of the infusion concentration, after storage as well.

Achyrocline , Onions , Asteraceae , Mitotic Index , Plants, Medicinal
Medicina (Ribeiräo Preto) ; 35(4): 497-504, out.-dez. 2002. ilus
Article in Portuguese | LILACS | ID: lil-400368


Considerando-se que as aferições da Acuidade Visual (AV) com os optotipos de Snellen não correspondem ao real poder da visão, desde a década de 1980, vêm os estudiosos pesquisando novas formas de avaliar o fenômeno, culminando com a aplicação da Função da Sensibilidade ao Contraste (FCS), um exame psicofísico, de inestimável valor no estabelecimento do diagnóstico precoce de inúmeras doenças. Entretanto, apesar do interesse despertado e dos valores relativos a sua sensibilidade e especificidade, o estudo da FSC não teve a utilização que seria de se esperar, na rotina oftalmológica, devido a resultados que, a princípio, parecem conflitantes. A despeito disso, para os autores deste artigo, as aparentes discrepƒncias são devidas a diferentes formas de abordagem do exame, cuja aplicação não tem obedecido a uma necess ria padronização metodológica, e acreditam que, tão logo haja uma uniformização de avaliação da FSC, os resultados passarão a ser coerentes e sua plena aceitação ser  um fato. Al‚m do grande valor no diagn¢stico precoce de inúmeras doençaas, a FSC também poder  ser muito útil na Medicina do Trabalho e na avaliação das condições psicofísicas de candidatos a obtenção de autorização para conduzir veículos automotores terrestres, marítimos e aéreos, podendo ser um fator limitante na habilitação dessas pessoas

Humans , Male , Female , Contrast Sensitivity , Diagnostic Techniques, Ophthalmological , Glaucoma , Ocular Hypertension