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1.
Acta Pharmaceutica Sinica B ; (6): 222-236, 2021.
Article in English | WPRIM | ID: wpr-881092

ABSTRACT

Lianhuaqingwen (LHQW) capsule, a herb medicine product, has been clinically proved to be effective in coronavirus disease 2019 (COVID-19) pneumonia treatment. However, human exposure to LHQW components and their pharmacological effects remain largely unknown. Hence, this study aimed to determine human exposure to LHQW components and their anti-COVID-19 pharmacological activities. Analysis of LHQW component profiles in human plasma and urine after repeated therapeutic dosing was conducted using a combination of HRMS and an untargeted data-mining approach, leading to detection of 132 LHQW prototype and metabolite components, which were absorbed

2.
Article in Chinese | WPRIM | ID: wpr-864509

ABSTRACT

Objective:To explore the effect of kangaroo care on the neurological behavior of neonatal intensive care unit (NICU) neonates with asphyxia.Methods:Totally 76 cases of neonatal asphyxia admitted to NICU from January 2018 to December 2018 were randomly divided into observation group (40 cases) and observation group (36 cases). The control group was given routine nursing care, while the observation group was given kangaroo nursing intervention on the basis of the control group. The neurobehavioral changes, the occurrence of nervous system damage and the physical development after 42 days of birth were compared between the two groups.Results:The scores of behavior ability (11.64 ± 0.26), original reflex (5.89 ± 0.32), passive muscle tension (7.64 ± 0.46), active muscle tension (7.83 ± 0.55), general reaction (6.17 ± 0.46) in the intervention observation group were significantly higher than those in the control group (11.02 ± 0.39), original reflex (5.53 ± 0.31), passive muscle tension (7.21 ± 0.47), active muscle tension (6.17 ± 0.46) Tension (7.41 ± 0.41), general reaction (5.88 ± 0.41) ( t values were 8.227, 4.970, 4.027, 3.740, 2.888, P<0.05). The incidence of neurological damage in the observation group was 2.50% (1/40) which was significantly lower than 16.67% (6/36) in the control group ( χ 2=4.117, P < 0.05). The growth of body weight (2.17 ± 0.42) kg, length (7.15 ± 1.74) cm and head circumference (4.38 ± 0.93) cm in the observation group were significantly higher than those in the control group (1.68 ± 0.39) kg, (5.89 ± 1.81) cm, (3.81 ± 0.79) cm ( t values were 5.252, 3.093, 2.863, P<0.05). Conclusion:Kangaroo nursing can effectively promote the neurological development and physical development of neonatal asphyxia, and reduce the nervous system damage of asphyxiated neonates, and the operation is simple and easy, which is worthy of clinical application.

3.
Article in English | WPRIM | ID: wpr-772269

ABSTRACT

Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents the first review on the cutting edge research of poly(amido amine) (PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP). PAMAM was excellent nucleation template, and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization. NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities. PAMAM+NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates, superior acid-neutralization, and ions release. Therefore, the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone. PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions. Besides, the long-term remineralization capability of PAMAM+NACP was established. After prolonged fluid challenge, the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration. Furthermore, the hardness of pre-demineralized dentin was increased back to that of healthy dentin, indicating a complete remineralization. Therefore, the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization, hardness increase, and caries-inhibition capabilities.


Subject(s)
Amines , Pharmacology , Calcium , Calcium Phosphates , Chemistry , Pharmacology , Dentin , Chemistry , Humans , Nanocomposites , Chemistry , Nanoparticles , Tooth Remineralization , Methods
4.
Chinese Journal of Epidemiology ; (12): 697-701, 2019.
Article in Chinese | WPRIM | ID: wpr-805456

ABSTRACT

Objective@#To investigate the relations between dietary intake during pregnancy and the incidence of their babies with small for gestational age (SGA).@*Methods@#Data on demographics, dietary intake of protein, fat, and carbohydrates of the pregnant mothers during the first, second and third trimester, were collected. Information related to birth weight and gestational age of the infants were also gathered. A total of 8 102 women, who delivered their babies at the First Affiliated Hospital of Shanxi Medical University from March 2012 to September 2016, were enrolled in this project. Among them, 961 mothers had infants with SGA but the other 7 141 of them having normal infants. Unconditional logistic regression model was used to analyze the effect of dietary nutrient intake on SGA the first, second and third trimester.@*Results@#We found that low dietary intake of protein during the first trimester and following trimesters during pregnancy were positively associated with higher risk of SGA (OR=1.534, 95%CI: 1.217-1.934; OR=1.268, 95%CI: 1.005-1.599; OR=1.310, 95%CI: 1.036-1.655). When adjusting for maternal pre-pregnancy BMI, we found that when mothers were with a pre-pregnancy BMI less than 18.5 or with low maternal intake of protein during the first trimester, positive association with higher risk of SGA (OR=1.872, 95%CI: 1.033-3.395; OR=1.754, 95%CI: 1.125-2.734), was noticed. However, for mothers with a pre-pregnancy BMI between 18.5 and 24.0 or with low protein intake during the first trimester, significant association with higher risk of SGA (OR=1.465, 95%CI: 1.089-1.972) was found.@*Conclusions@#Through our observation, maternal dietary intake during pregnancy seemed to be associated with the risk of SGA but the effects of dietary intake were different, according to the BMI of pre-pregnancy population. Early pregnancy appeares as the key period for dietary intake which may influence the SGA.

5.
Chinese Journal of Epidemiology ; (12): 682-685, 2019.
Article in Chinese | WPRIM | ID: wpr-805453

ABSTRACT

Objective@#To explore the effect of lipopolysaccharide intervention program on Legionella pneumonia.@*Methods@#C3H/HeN mice (6-8 weeks old) were used as experimental animals. The mice were randomly divided into lipopolysaccharide intervention, non-lipopolysaccharide intervention and control groups. Each group was again divided into three time points: 12 h, 24 h and 48 h. Mice in the lipopolysaccharide intervention group were intraperitoneally injected with E. coli lipopolysaccharide (100 ng per mice), and the rest groups were intraperitoneally injected with normal saline. After 24 hours, mice in the lipopolysaccharide intervention and the non-intervention groups mice were infected with Legionella by tracheal injection and the control group was given the same amount of saline. All the mice were killed at 12, 24 and 48 hours respectively. The mice were anatomized, lungs of the mice were separated and weighed. Organ coefficients (lung weight/body weight of mice) were calculated. 1 ml Orbital blood was collected. Toll-like receptor 4 (TLR4) levels of peripheral blood mononuclear cells were measured by flow cytometry. The contents of TNF-α and IL-1β in the upper left lung lobe were measured by ELISA.@*Results@#In the lung organs, the coefficients of lipopolysaccharide non-intervention group were higher than the other groups and there was no significant difference seen between the lipopolysaccharide intervention group and the controls. TLR4 peaked at 12 hours in both the lipopolysaccharide intervention and the non-intervention groups while the TLR4 level in the intervention group was higher than that in the non-intervention group. There were no significant differences appeared on the TLR4 expression levels between the two Legionella pneumonia modelled groups at 24 or 48 hours. There was no significant difference seen regarding the concentration of TNF-α and IL-1β between the intervention and the control groups. The secretion levels of TNF-α and IL-1β in the non-intervention group were higher than those in the intervention group at each time point.@*Conclusion@#The lipopolysaccharide intervention program may alleviate the inflammatory symptoms of Legionella infection.

6.
Chinese Journal of Epidemiology ; (12): 830-835, 2018.
Article in Chinese | WPRIM | ID: wpr-738055

ABSTRACT

Objective To investigate the influence of dietary cholesterol intake on gestational diabetes mellitus (GDM),at one year prior to and first and second trimesters of pregnancy.Methods Between March 2012 and September 2016,the pregnant women from the First Affiliated Hospital of Shanxi Medical University were asked to fill in a set of questionnaires,by which information on general demographic characteristics,diagnosis of GDM and dietary cholesterol intake was collected.Unconditional logistic regression method was used to analyze the influence of dietary cholesterol intake on GDM,at one year prior to and first and second trimesters of pregnancy.The association on dietary cholesterol intake and GDM between age groups was also analyzed.Results Data on 9 005 subjects,including 1 388 pregnant women with GDM,was collected.When the amount of cholesterol intake was stratified into quartile,results from the unconditional logistic regression showed that dietary cholesterol intake appeared ≥76.50 mg/d,both in the periods of one year prior to and the second trimester of pregnancy.This amount of dietary cholesterol intake would increase the risk of GDM (one year prior to pregnant:OR=1.230,95%CI:1.018-1.485;second trimester:OR=1.228,95%C1:1.014-1.486).Women who took ≥76.50 mg/d of daily cholesterol during the period of one year prior to,or 46.75-76.50 mg/d during the second trimester of pregnancy,the risks of GDM (OR=4.644,95%CI:1.106-19.499) would increase.Women with daily cholesterol intake over 76.50 mg/d during the period of one year prior to or at the second trimester of pregnancy,there appeared a risk on GDM (OR=1.217,95% CI:1.012-1.463).When maternal age was divided in two different subgroups and the cholesterol intake level was ≥76.50 mg/d both in the period of one year prior to pregnancy or at the second trimester,the risk of GDM appeared in the subgroup of <35 years old (OR=1.336,95%CI:1.083-1.647;OR=1.341,95%CI:1.087-1.654).However,no significant association was found in the maternal age group of ≥35 years old.Conclusion High level of dietary cholesterol intake would increase the risk of GDM,both in the period of one year prior to and at the second trimester of pregnancy.

7.
Chinese Journal of Epidemiology ; (12): 805-809, 2018.
Article in Chinese | WPRIM | ID: wpr-738050

ABSTRACT

Objective To explore the relationship between the status of HBsAg-positive infection of mothers and the non/low-response to hepatitis B vaccine of their infants.Methods A total of 225 pairs of mothers and their infants were recruited in our cohort from June 2011 to July 2013.Infants were given three doses of hepatitis B vaccine at hour 24,first month and month 6th respectively and were followed up for one year after birth.HBV serological markers and HBV DNA in the peripheral blood of both mothers and infants were detected by Electro-chemiluminescence immunoassay and fluorescence quantitative Polymerase Chain Reaction.Results Six HBV infection models were detected in HBsAg-positive mothers,and "HBsAg (+),HBeAg (+),anti-HBc (+)" (model one) and "HBsAg (+),anti-HBe (+),anti-HBc (+)" (model two) accounted for 92.5% (208/225) of all the models.Rate of non/low-response to hepatitis B vaccine in infants born to mothers in model one was lower than those in model two,the differences are statistically significant (x2=4.80,P=0.029).The rate of non/low-response to hepatitis B vaccine in infants showed a downward trend with the rising of HBeAg level in their mothers (x2=4.86,P=0.028).Results from the unconditional logistic regression analysis showed that the HBeAg of the HBsAg-positive mothers was significantly correlated with the low risk of non/low-response to hepatitis B vaccine in infants (OR=0.598,95%CI:0.378-0.947).The positive rate of serum HBV DNA in HBsAg-positive mothers was 54.2%,while the rate of non/low-response to hepatitis B vaccine in infants born to HBV DNA positive mothers was similar to those infants born to HBV DNA negative mothers (X2=0.22,P=0.640).Conclusions "HBsAg (+),HBeAg (+),anti-HBc (+)" and "HBsAg (+),anti-HBe(+),anti-HBc (+)" were the common models seen in HBsAg-positive mothers,and the rate of non/low-response to hepatitis B vaccine was different between the two models.HBeAg of HBsAg-positive mothers might have positive effects on the immune response to hepatitis B vaccine in infants but the mechanisms remained not clear.HBV DNA of the HBsAg-positive mothers did not seem to be correlated with the immune response to hepatitis B vaccine in infants.

8.
Chinese Journal of Epidemiology ; (12): 631-635, 2018.
Article in Chinese | WPRIM | ID: wpr-738014

ABSTRACT

Objective To estimate the prevalence of HIV/HCV co-infection and explore the influence factors and their interaction on HIV/HCV co-infection of patient's access to methadone maintenance treatment (MMT).Methods A face to face interviews were conducted among 750 patients at two MMT clinics in Guangxi Zhuang Autonomous Region.The questionnaires information included demographic characteristics,HIV and HCV infection status,history of drug abuse,urine test for morphine,high risk sex behaviors,needle sharing,dropped out etc.Methods of x2 test one-way,multivariate logistic regression and interactions were used to analyze the related factors of HIV/HCV co-infection.Results The study subjects included 750 participants,18.31% (127/691) of patients were co-infected with HIV and HCV.The HIV/HCV co-infection rate in patients who shared needles with others or dropped out of treatment was 35.84% (81/226) and 19.88% (64/322) respectively,which were higher than those who have never shared needles or dropped out (9.89%,46/465 and 17.07%,63/369).Logistic regression analysis results showed that after adjusted for confounding factors,patients who shared needles (OR=4.50,95%CI:2.72-7.43) and dropped out of treatment (OR=1.71,95%CI:1.04-2.80) were more likely to be infected with HIV/HCV.Interaction analysis showed that sharing needles and dropping out of treatment exist additive effect on co-infection of HIV and HCV (RERI=4.21,AP=0.44,SI=1.95).Conclusions Needle sharing and dropping out of treatment are associated with HIV/HCV co-infection.Health education,psychological counseling and other measures should be taken to reduce needle sharing and dropping out of MMT.

9.
Chinese Journal of Epidemiology ; (12): 830-835, 2018.
Article in Chinese | WPRIM | ID: wpr-736587

ABSTRACT

Objective To investigate the influence of dietary cholesterol intake on gestational diabetes mellitus (GDM),at one year prior to and first and second trimesters of pregnancy.Methods Between March 2012 and September 2016,the pregnant women from the First Affiliated Hospital of Shanxi Medical University were asked to fill in a set of questionnaires,by which information on general demographic characteristics,diagnosis of GDM and dietary cholesterol intake was collected.Unconditional logistic regression method was used to analyze the influence of dietary cholesterol intake on GDM,at one year prior to and first and second trimesters of pregnancy.The association on dietary cholesterol intake and GDM between age groups was also analyzed.Results Data on 9 005 subjects,including 1 388 pregnant women with GDM,was collected.When the amount of cholesterol intake was stratified into quartile,results from the unconditional logistic regression showed that dietary cholesterol intake appeared ≥76.50 mg/d,both in the periods of one year prior to and the second trimester of pregnancy.This amount of dietary cholesterol intake would increase the risk of GDM (one year prior to pregnant:OR=1.230,95%CI:1.018-1.485;second trimester:OR=1.228,95%C1:1.014-1.486).Women who took ≥76.50 mg/d of daily cholesterol during the period of one year prior to,or 46.75-76.50 mg/d during the second trimester of pregnancy,the risks of GDM (OR=4.644,95%CI:1.106-19.499) would increase.Women with daily cholesterol intake over 76.50 mg/d during the period of one year prior to or at the second trimester of pregnancy,there appeared a risk on GDM (OR=1.217,95% CI:1.012-1.463).When maternal age was divided in two different subgroups and the cholesterol intake level was ≥76.50 mg/d both in the period of one year prior to pregnancy or at the second trimester,the risk of GDM appeared in the subgroup of <35 years old (OR=1.336,95%CI:1.083-1.647;OR=1.341,95%CI:1.087-1.654).However,no significant association was found in the maternal age group of ≥35 years old.Conclusion High level of dietary cholesterol intake would increase the risk of GDM,both in the period of one year prior to and at the second trimester of pregnancy.

10.
Chinese Journal of Epidemiology ; (12): 805-809, 2018.
Article in Chinese | WPRIM | ID: wpr-736582

ABSTRACT

Objective To explore the relationship between the status of HBsAg-positive infection of mothers and the non/low-response to hepatitis B vaccine of their infants.Methods A total of 225 pairs of mothers and their infants were recruited in our cohort from June 2011 to July 2013.Infants were given three doses of hepatitis B vaccine at hour 24,first month and month 6th respectively and were followed up for one year after birth.HBV serological markers and HBV DNA in the peripheral blood of both mothers and infants were detected by Electro-chemiluminescence immunoassay and fluorescence quantitative Polymerase Chain Reaction.Results Six HBV infection models were detected in HBsAg-positive mothers,and "HBsAg (+),HBeAg (+),anti-HBc (+)" (model one) and "HBsAg (+),anti-HBe (+),anti-HBc (+)" (model two) accounted for 92.5% (208/225) of all the models.Rate of non/low-response to hepatitis B vaccine in infants born to mothers in model one was lower than those in model two,the differences are statistically significant (x2=4.80,P=0.029).The rate of non/low-response to hepatitis B vaccine in infants showed a downward trend with the rising of HBeAg level in their mothers (x2=4.86,P=0.028).Results from the unconditional logistic regression analysis showed that the HBeAg of the HBsAg-positive mothers was significantly correlated with the low risk of non/low-response to hepatitis B vaccine in infants (OR=0.598,95%CI:0.378-0.947).The positive rate of serum HBV DNA in HBsAg-positive mothers was 54.2%,while the rate of non/low-response to hepatitis B vaccine in infants born to HBV DNA positive mothers was similar to those infants born to HBV DNA negative mothers (X2=0.22,P=0.640).Conclusions "HBsAg (+),HBeAg (+),anti-HBc (+)" and "HBsAg (+),anti-HBe(+),anti-HBc (+)" were the common models seen in HBsAg-positive mothers,and the rate of non/low-response to hepatitis B vaccine was different between the two models.HBeAg of HBsAg-positive mothers might have positive effects on the immune response to hepatitis B vaccine in infants but the mechanisms remained not clear.HBV DNA of the HBsAg-positive mothers did not seem to be correlated with the immune response to hepatitis B vaccine in infants.

11.
Chinese Journal of Epidemiology ; (12): 631-635, 2018.
Article in Chinese | WPRIM | ID: wpr-736546

ABSTRACT

Objective To estimate the prevalence of HIV/HCV co-infection and explore the influence factors and their interaction on HIV/HCV co-infection of patient's access to methadone maintenance treatment (MMT).Methods A face to face interviews were conducted among 750 patients at two MMT clinics in Guangxi Zhuang Autonomous Region.The questionnaires information included demographic characteristics,HIV and HCV infection status,history of drug abuse,urine test for morphine,high risk sex behaviors,needle sharing,dropped out etc.Methods of x2 test one-way,multivariate logistic regression and interactions were used to analyze the related factors of HIV/HCV co-infection.Results The study subjects included 750 participants,18.31% (127/691) of patients were co-infected with HIV and HCV.The HIV/HCV co-infection rate in patients who shared needles with others or dropped out of treatment was 35.84% (81/226) and 19.88% (64/322) respectively,which were higher than those who have never shared needles or dropped out (9.89%,46/465 and 17.07%,63/369).Logistic regression analysis results showed that after adjusted for confounding factors,patients who shared needles (OR=4.50,95%CI:2.72-7.43) and dropped out of treatment (OR=1.71,95%CI:1.04-2.80) were more likely to be infected with HIV/HCV.Interaction analysis showed that sharing needles and dropping out of treatment exist additive effect on co-infection of HIV and HCV (RERI=4.21,AP=0.44,SI=1.95).Conclusions Needle sharing and dropping out of treatment are associated with HIV/HCV co-infection.Health education,psychological counseling and other measures should be taken to reduce needle sharing and dropping out of MMT.

12.
Chinese Journal of Neurology ; (12): 754-758, 2018.
Article in Chinese | WPRIM | ID: wpr-711019

ABSTRACT

Progression of acute isolated pontine infarction (IPI) is a common clinical event that positively correlates with the patients' adverse prognosis.Therefore,exploration on the relevant factors and predictors to the progression of IPI has become the current research hotspot.To date,the relevant factors that have been proposed include basilar artery branch disease,female,hypertension and blood pressure fluctuation,hyperglycemia,morphological features of the lesions (ventral surface of pons involvement,located at the lower pons,multiple axial slices affected,conglomerated beads shape),severe white matter diseases,atherosclerosis,long diameter and midline location of basilar artery,and so on.However,the interpretation on existing results has to be cautious as the definition for progressive IPI,criteria for inclusion and exclusion,and examinations are inconsistent in different studies.The investigation on relevant factors to the progression of IPI still requires standardized,large-scale prospective clinical studies.

13.
Chinese Medical Ethics ; (6): 194-197, 2018.
Article in Chinese | WPRIM | ID: wpr-706066

ABSTRACT

Under the"Internet +" era, some medical staff' s treatment philosophy cannot adapt to the current situation, and patients are prone to produce high expectations because of inadequate basic medical knowledge and the habit of acquiring medical information from Internet. However, when the difference between reality and expec-tations are large, they might be in disputes with medical staffs, and coupled with the lag of hospital management, the doctor-patient communication often is not smooth situation. Therefore, it is recommended that medical staffs improve humanistic quality meanwhile improving technology, patients should develop the habit of acquiring medical information from Internet correctly, hospital needs to optimize management and allocate medical resource reasona-bly, and society should also create positive atmosphere.

14.
Chinese Journal of Epidemiology ; (12): 1624-1628, 2017.
Article in Chinese | WPRIM | ID: wpr-737886

ABSTRACT

Objective To reveal the prevalence and the related factors of hepatitis B (HepB) virus infection among HIV/AIDS patients.Methods We conducted a cross-sectional study in two HIV clinics,affiliated to local Centers of Disease Control and Prevention in Guangxi Zhuang Autonomous Regional.A face-to-face interview,with questionnaire was conducted to collect information on socio-demographic characteristics,drug use,and sexual behavior.Blood samples were used to test HBsAg.x2 test or Fisher's exact test and unconditional logistic regression models were used to identify the influencing factors.Results The prevalence of HBV and HIV co-infection was 13.85% (113/816).Results from multivariate logistic regression analyses showed that age (25-45),family history of HBV and history of HepB vaccination were independent influencing factors for HBV and HIV coinfection,with OR (95% CI) as 1.738 (1.031-2.931),2.898 (1.678-5.005) and 1.744 (1.052-2.892),respectively.Conclusion The prevalence of HBV among HIV/AIDS patients was significantly higher than that in general population.HIV/AIDS patients aged between 25 and 45 and with family history of HBV were more likely to be infected with HBV,while HepB vaccination was associated with the reduction of HIV/HBV coinfection.Specific comprehensive prevention and treatment programs on HIV/AIDS patients need to be set up.

15.
Chinese Journal of Epidemiology ; (12): 1410-1414, 2017.
Article in Chinese | WPRIM | ID: wpr-737844

ABSTRACT

Objective To explore the relationship between HBeAg in HBsAg positive mothers and CD4 + CD25 + Foxp3 + regulatory T cells (Treg) in newborns,as well as how they would influence the increasing risk on HBV intrauterine transmission.Methods We collected information on general demographic characteristics and delivery on 270 HBsAg positive mothers and their newborns from the Third People's Hospital of Taiyuan.Fluorescence quantitative polymerase chain reaction (FQ-PCR) and chemiluminescence immunoassay (CLIA) were used to detect HBV DNA and HBV serological markers in peripheral blood from both mothers and neonates.The expression of Treg and other immune cells in peripheral blood of neonates were detected with flow cytometry (FCM).Results Maternal HBeAg positive rates were associated with an increased risk of intrauterine transmission (0R=4.08,95% CI:1.89-8.82).Rates of T.reg in newborns born to HBsAg-positive mothers were higher than that of the negative group (Z=2.29,P=0.022).Each pair of the subjects was assigned to five different groups according to the HBeAg titers of mothers.Frequencies of both Treg and HBeAg in newboms and HBV DNA in mothers between the above said 5 groups showed similar trends of changing patterns and the differences between groups were statistically significant (x2=18.73,P<0.001;x2=181.60,P<0.001;x2=183.09,P<0.001).Results from partial correlation analysis showed that after adjusting for neonatal HBeAg and maternal HBV DNA,mother's HBeAg titers were positively related to the percentage of Treg in their newboms (rs=0.19,P=0.039).In addition,the frequencies of Treg were negatively correlated with pDC and CD4 + T cell in their newborns (rs=-0.21,P=0.017;r,=-0.23,P=0.009).Conclusion HBeAg from HBsAg positive mothers might have inhibited the function of neonatal DC cells and T cells to reduce the immune response to HBV by up-regulating the proportion of Treg and finally increased the risk of HBV intrauterine transmission.

16.
Chinese Journal of Epidemiology ; (12): 1263-1268, 2017.
Article in Chinese | WPRIM | ID: wpr-737816

ABSTRACT

Objective To investigate the association between periconceptional folic acid supplementation and small for gestational age (SGA) birth based on maternal pre-pregnancy body mass index (BMI) and provide evidence for the development of comprehensive prevention programs on SGA birth.Methods Between March,2012 and September,2016,a total of 8 523 pregnant women delivering in the First Affiliated Hospital of Shanxi Medical University were surveyed to collect the information about their demographic characteristics,folic acid supplementation before and during pregnancy and about their infants.Among their infants,1 066 were small for gestational age (case group),7 457 were appropriate for gestational age (AGA) (control group).Unconditional logistic regression model was used to evaluate the association between periconceptional folic acid supplementation and SGA birth in the context of different pre-pregnancy BMI.Results The overall incidence of SGA birth was 12.51% (1 066/8 523).After adjusting the confounding factors,prepregnancy BMI< 18.5 kg/m2 was a risk factor for SGA birth (OR=1.22,95% CI:1.01-1.47),prepregnancy BMI≥24.0 kg/m2 was associated with a reduced risk of SGA birth (OR=0.81,95%CI:0.68-0.97).After adjusting confounding factors,periconceptional folic acid supplementation was a protective factor for SGA birth (OR=0.82,95%CI:0.68-0.98).After stratified by pre-pregnancy BMI,periconceptional folic acid supplementation was associated with the reduced risk of SGA birth in overweight group (24.0 kg/m2≤BMI<28.0 kg/m2) with OR of 0.55 (95%CI:0.36-0.85).No significant association was observed in other groups.When examined by folic acid supplement type,periconceptional single folic acid supplementation (400 μg per tablet) was a protective factor for SGA birth (OR=0.82,95% CI:0.69-0.99).After stratified by pre-pregnancy BMI,periconceptional single folic acid supplementation (400 μg per tablet) was associated with the reduced risk of SGA birth in overweight groups (OR =0.56,95 % CI:0.36-0.86).No association was observed between periconceptional folic acid containing multivitamin supplementation and SGA birth.Conclusions Periconceptional folic acid supplementation (400 μg) was associated with reduced risk of SGA birth in women with prepregnancy BMI≥24.0 kg/m2 and <28.0 kg/m2.No association between folic acid supplementation and SGA was observed in other groups.This study suggests that pre-pregnancy BMI might modify the influence of folic acid supplementation on the risk of SGA birth.

17.
Chinese Journal of Epidemiology ; (12): 950-953, 2017.
Article in Chinese | WPRIM | ID: wpr-737753

ABSTRACT

Objective To explore the effect of interleukin-6 (IL-6) and Interleukin-12(IL-12) on immune response to hepatitis B vaccination in infants of HBsAg-positive mothers.Methods A total of 91 neonates whose mothers were HBsAg-positive were included and followed up for 12 months.HBV DNA and HBV serological markers in the peripheral blood of the neonates and infants were detected with fluorescence quantitative polymerase chain reaction (FQ-PCR) and chemiluminescence immunoassay (CLIA),and the levels of IL-6 and IL-12 in the peripheral blood of the neonates and infants were detected with enzyme-linked immunosorbent assay (ELISA).Results The non-/hypo-response rate to hepatitis B vaccination was 35.16% (32/91) in the 91 infants.In the neonatal period and infantile period,the level of IL-6 in non-/hypo-response group was lower than that in high-response group,while the level of IL-12 was higher than that in high-response group,and there was significant difference (P<0.01).From the neonatal period to the infantile period,the level of IL-6 increased,while the level of IL-12 descended in both groups,and there was significant difference (P<0.01).Furthermore,the level of anti-HBs of infants was positively correlated with the level of IL-6 (rs =0.70,0.79,P< 0.01),and was negatively correlated with the level of IL-12 (rs=-0.71,-0.72,P<0.01) in the neonatal period and the infantile period.From the neonatal period to the infantile period,the increased level of IL-6 was positively associated with the level of anti-HBs (rs =-0.74,P<0.01),while the decreased level of IL-12 was negatively associated with the level of anti-HBs (rs=-0.42,P<0.01).The level of IL-6 was negatively correlated with the level of IL-12 in the neonatal period and the infantile period (rs=-0.68,-0.70,P<0.01).Conclusions IL-6 might promote the immune response to hepatitis B vaccination in infants whose mothers were HBsAg-positive,while IL-12 might inhibit the immune response.IL-6 and IL-12 would affect the immune response to hepatitis B vaccination in infants of HBsAg-positive mothers at the same time.

18.
Chinese Journal of Epidemiology ; (12): 911-915, 2017.
Article in Chinese | WPRIM | ID: wpr-737746

ABSTRACT

Objective To investigate the influencing factors for non/low-response to hepatitis B vaccine in infants of HBsAg-positive mothers.Methods A total of 286 HBsAg-positive pregnant women and their infants were recruited from the Third People's Hospital of Taiyuan during July 2011 to January 2013.The infants were immunized with hepatitis B vaccine according to the 0-1-6 month vaccination schedule and followed up for 12 months.The serum HBV DNA level of mothers,neonates and infants were detected by electro chemilum inescence immunoassay kits and fluorescene quantiative polymerase chain rection.Results Among 286 infants,the rate of non/low-response to hepatitis B vaccine was 18.53% (53/286).Non-conditional logistic regression analysis indicated that the mother's HBV DNA level ≥ 1 × 107 copies/ml (0R=2.592,95%CI:1.121-5.996) and natural birth (OR=1.932,95%CI:1.021-3.654) were the risk factors for non/low-response to hepatitis B vaccine,the risks were 2.592 times and 1.932 times higher compared with the infants whose mothers were HBV DNA negative and the infants whose mothers had cesarean delivery.There was no multiplicative or additive interaction between high HBV DNA load and natural birth (OR=1.055,95%CI:0.209-5.321),(RERI=1.617,95%CI:-4.038-7.272;AP=0.364,95%CI:-).527-1.225;SI=1.195,95%CI:0.270-13.135).After stratified analysis of mother's HBV DNA level,delivery mode of mothers was not associated with non/low-response of their infants.Conclusion The mother's load of HBV DNA ≥ 1 × 107 copies/ml might be the factor for non/low-response to hepatitis B vaccine in infants of HBsAg positive mothers.

19.
Chinese Journal of Epidemiology ; (12): 646-650, 2017.
Article in Chinese | WPRIM | ID: wpr-737700

ABSTRACT

Objective To estimate the incidence of drop out of treatment in patients with access to methadone maintenance treatment and explore the correlation and interaction between insufficient methadone dosage and morphine positive urine on the drop out in Guangxi Zhuang Autonomous Region.Methods Face to face interview was conducted in 1 031 patients at 3 methadone maintenance treatment clinics in Guangxi.Results The study included 1 031 participants,40.6% of them (419/1 031) had stopped treatment.The drop out rates in urine morphine positive group and methadone dosage < 100 mg/d group were 57.6% (99/172) and 37.4% (347/929) respectively,higher than those in urine morphine negative group and methadone dosage ≥ 100 mg/d group (42.3%,363/ 859,and 26.5%,27/102).Orderly logistic regression analysis results showed that after adjusted factors,such as gender,age,marital status,ethnic group,patients who received a dosage less than 1 00 mg/day (OR=3.05,95%CI:1.84-5.06) and had morphine positive urine (OR=2.25,95%CI:1.59-3.19) were more likely to drop out of the treatment.Interaction analysis showed that dosage less than 100 mg/d and morphine positive urine during treatment had additive interaction (RERI=256.46,AP=0.87,S=8.05) and multiplication interaction (OR=2.45,95%CI:1.71-3.49).Conclusion Insufficient dosage and morphine positive urine were significantly correlated with drop out of treatment in patients with access to methadone maintenance treatment.

20.
Chinese Journal of Epidemiology ; (12): 1624-1628, 2017.
Article in Chinese | WPRIM | ID: wpr-736418

ABSTRACT

Objective To reveal the prevalence and the related factors of hepatitis B (HepB) virus infection among HIV/AIDS patients.Methods We conducted a cross-sectional study in two HIV clinics,affiliated to local Centers of Disease Control and Prevention in Guangxi Zhuang Autonomous Regional.A face-to-face interview,with questionnaire was conducted to collect information on socio-demographic characteristics,drug use,and sexual behavior.Blood samples were used to test HBsAg.x2 test or Fisher's exact test and unconditional logistic regression models were used to identify the influencing factors.Results The prevalence of HBV and HIV co-infection was 13.85% (113/816).Results from multivariate logistic regression analyses showed that age (25-45),family history of HBV and history of HepB vaccination were independent influencing factors for HBV and HIV coinfection,with OR (95% CI) as 1.738 (1.031-2.931),2.898 (1.678-5.005) and 1.744 (1.052-2.892),respectively.Conclusion The prevalence of HBV among HIV/AIDS patients was significantly higher than that in general population.HIV/AIDS patients aged between 25 and 45 and with family history of HBV were more likely to be infected with HBV,while HepB vaccination was associated with the reduction of HIV/HBV coinfection.Specific comprehensive prevention and treatment programs on HIV/AIDS patients need to be set up.

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