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Int. braz. j. urol ; 49(5): 580-589, Sep.-Oct. 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1506417


ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

Int. braz. j. urol ; 37(3): 314-319, May-June 2011. tab
Article in English | LILACS | ID: lil-596005


PURPOSE: To compare the efficacy of three different formulations containing Betamethasone Valerate versus placebo in the topical treatment of phimosis. As a secondary goal, we compared the outcomes after 30 and 60 days of treatment. MATERIALS AND METHODS: Two hundred twenty boys aged 3 to 10 years old with clinical diagnosis of phimosis were enrolled. Patients were randomized to one of the following groups: Group 1: Betamethasone Valerate 0.2 percent plus Hyaluronidase; Group 2: Betamethasone Valerate 0.2 percent; Group 3: Betamethasone Valerate 0.1 percent or Group 4: placebo. Parents were instructed to apply the formula twice a day for 60 days and follow-up evaluations were scheduled at 30, 60 and 240 days after the first consultation. Success was defined as complete and easy foreskin retraction. RESULTS: One hundred ninety-five patients were included at our final analysis. Group 1 (N = 54), 2 (N = 51) and 3 (N = 52) had similar success and improvement rates, all treatment groups had higher success rates than placebo(N = 38). After 60 days of treatment, total and partial response rates for Groups 1, 2 and 3 were 54.8 percent and 40.1 percent, respectively, while placebo had a success rate of 29 percent. Success and improvement rates were significantly better in 60 days when compared to 30 days. CONCLUSIONS: Betamethasone Valerate 0.1 percent, 0.2 percent and 0.2 percent in combination with Hyaluronidase had equally higher results than placebo in the treatment of phimosis in boys from three to ten years-old. Patients initially with partial or no response can reach complete response after 60 days of treatment.

Child , Child, Preschool , Humans , Male , /administration & dosage , Glucocorticoids/administration & dosage , Hyaluronoglucosaminidase/administration & dosage , Phimosis/drug therapy , Administration, Topical , Double-Blind Method , Drug Administration Schedule , Prospective Studies , Treatment Outcome
Einstein (Säo Paulo) ; 7(4)2009. tab
Article in Portuguese | LILACS | ID: lil-541622


Objective: The aim of the present study was to assess the influence of video game as warm-up before dry-lab laparoscopic activities. Methods: Eleven medical students participated in this prospective randomized crossover study. Students were divided into two groups. Students in Group 1 had to execute an interrupted suture with the dominant hand using a standardized technique (non-video game group). Students in Group 2 performed the same suture, but after playing a video game match (video game group). After this initial task, groups were crossed. The time spent to complete each task was recorded, and the participants and observers had to judge the performance for each laparoscopic exercise. These variables were used as a measure of performance. Results: Mean time for laparoscopic surgery in this subset of inexperienced laparoscopic students was similar between non-video game versus video game groups (254.6 ± 187.7 versus 255.8 ± 183.6; p = 0.875). Subjective impression of observers regarding students? performance was also similar (p = 0.662), but subjective impression of the participant about his own performance was different between both groups, with 64.7 versus 20.0% of participants that considered their performance good for video game versus non-video game groups (p = 0.044). Conclusions: In conclusion, video games used as warm-up for laparoscopic practice seem to make inexperienced surgeons more confident and comfortable with the procedures, even though objective measures, as operative time and observers impression of surgeons performance do not seem to be affected by video game warm-up.

Objetivo: Avaliar o efeito de um jogo de video game como aquecimento pré-operatório para o cirurgião laparoscópico. Métodos: Foi realizado um estudo prospectivo cruzado com 11 estudantes de medicina e médicos residentes com pouca experiência em laparoscopia. Um grupo realizou suturas laparoscópicas em caixa preta sem aquecimento inicial, enquanto outro realizou aquecimento por meio de jogos de video game. Os grupos foram cruzados em um segundo momento. Resultados: O tempo médio para confecção de sutura laparoscópica foi semelhante entre os grupos Direto versus Video game (254,6 ± 187,7 versus 255,8 ± 183,6; p = 0,875). A impressão subjetiva dos avaliadores sobre o grau de dificuldade para a realização da tarefa também foi semelhante entre os grupos (p = 0,662). Em relação à percepção do cirurgião quanto ao grau de dificuldade para a realização do procedimento cirúrgico, observou-se que os cirurgiões do grupo Video game versus Direto tiveram uma percepção subjetiva de maior facilidade para a realização do exercício, sendo que a porcentagem de exercícios considerados de dificuldade baixa ou moderada foi de 64,7 versus 20,0% entre os grupos (p = 0,044). Conclusões: O emprego de jogo de video game como aquecimento para a cirurgia laparoscópica em cirurgiões pouco experientes parece torná-los mais receptivos para as dificuldades do procedimento, embora não altere o tempo para a realização dos procedimentos e nem a percepção alheia do grau de dificuldade.

Int. braz. j. urol ; 34(6): 739-748, Nov.-Dec. 2008. tab
Article in English | LILACS | ID: lil-505669


PURPOSE: Although laparoscopy is considered the mainstay for most renal procedures in adults, its role in the pediatric population is still controversial, especially for smaller children. We reviewed our experience in pediatric renal laparoscopic surgery in three pediatric age groups in an attempt to identify if age has an impact on feasibility and surgical outcomes. MATERIALS AND METHODS: From November 1995 to May 2006, 144 pediatric laparoscopic renal procedures were performed at our institution. The charts of these patients were reviewed for demographic data, urologic pathology and surgical procedure, as well as perioperative complications and post-operative outcomes. The findings were stratified into 3 groups, according to patient age (A: < 1 year, B: 1 to 5 years and C: 6-18 years). RESULTS: Median age of the patients was 4.2 years (42 days - 18 years). We performed 54 nephrectomies, 33 nephroureterectomies, 19 upper pole nephrectomies, 11 radical nephrectomies, 22 pyeloplasties and 4 miscellaneous procedures. The 3 age groups were comparable in terms of the procedures performed. Conversion rates were 0 percent, 1.4 percent and 1.9 percent for groups A, B and C, respectively (p = 0.72). Incidence of perioperative complications was 5 percent, 8.2 percent and 7.8 percent for age groups A to C, respectively (p = 0.88). CONCLUSIONS: Most renal procedures can be performed safely by laparoscopy in the pediatric population, with excellent aesthetic and functional outcomes. The morbidity related to the procedure was minimal irrespective of the age group.

Adolescent , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Kidney Diseases/surgery , Laparoscopy , Age Factors , Feasibility Studies , Intraoperative Complications , Laparoscopy/adverse effects , Laparoscopy/methods , Postoperative Complications , Time Factors , Treatment Outcome
Int. braz. j. urol ; 32(3): 316-321, May-June 2006. ilus
Article in English | LILACS | ID: lil-433380


OBJECTIVES: Describe and illustrate a new minimally invasive approach for the radical resection of inguinal lymph nodes. SURGICAL TECHNIQUE: From the experience acquired in 7 operated cases, the video endoscopic inguinal lymphadenectomy (VEIL) technique was standardized in the following surgical steps: 1) Positioning of the inferior member extended in abduction, 2) Introduction of 3 work ports distal to the femoral triangle, 3) Expansion of the working space with gas, 4) Retrograde separation of the skin flap with a harmonic scalpel, 5) Identification and dissection of the long saphenous vein until the oval fossa, 6) Identification of the femoral artery, 7) Distal ligature of the lymph node block at the femoral triangle vertex, 8) Liberation of the lymph node tissue up to the great vessels above the femoral floor, 9) Distal ligature of the long saphenous vein, 10) Control of the saphenofemoral junction, 11) Final liberation of the surgical specimen and endoscopic view showing that all the tissue of the region was resected, 12) Removal of the surgical specimen through the initial orifice, 13) Vacuum drainage and synthesis of the incisions. COMMENTS: The VEIL technique is feasible and allows the radical removal of inguinal lymph nodes in the same limits of conventional surgery dissection. The main anatomic repairs of open surgery can be identified by the endoscopic view, confirming the complete removal of the lymphatic tissue within the pre-established limits. Preliminary results suggest that this technique can potentially reduce surgical morbidity. Oncologic follow-up is yet premature to demonstrate equivalence on the oncologic point of view.

Humans , Male , Inguinal Canal/surgery , Lymph Node Excision/methods , Video-Assisted Surgery/methods , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Lymphatic Metastasis , Prospective Studies , Penile Neoplasms/pathology , Penile Neoplasms/surgery , Treatment Outcome
Int. braz. j. urol ; 31(6): 526-533, Nov.-Dec. 2005. tab
Article in English | LILACS | ID: lil-420478


INTRODUCTION: We describe our experience with hand-assisted laparoscopy (HAL) as an option for the treatment of large renal specimens. MATERIALS AND METHODS: Between March 2000 and August 2004, 13 patients candidate to nephrectomies due to benign renal conditions with kidneys larger than 20 cm were included in a prospective protocol. Unilateral nephrectomy was performed in cases of hydronephrosis (6 patients) or giant pyonephrosis (4 patients). Bilateral nephrectomy was performed in 3 patients with adult polycystic kidney disease (APKD) with low back pain refractory to clinical treatment previous to kidney transplant. The technique included the introduction of 2 to 3 10 mm ports, manual incision to allow enough space for the surgeon's wrist without a commercial device to keep the pneumoperitoneum. The kidney was empty, preferably extracorporeally, enough to be removed through manual incision. We have assessed operative times, transfusions, complications, conversions, hospital stay and convalescence. RESULTS: The patients mean age (9 women and 4 men) was 58 years. Mean operating time was 120 n 10 min (hydronephrosis), 160 n 28 min (pyonephrosis) and 190 n 13 min (bilateral surgery for APKD). There was a need for a conversion in 1 case and another patient needed a transfusion due to a lesion in the renal vein; 2 patients had minor complications. CONCLUSION: HAL surgery is a minimally invasive alternative in the treatment of large renal specimens, with or without significant inflammation.

Humans , Male , Female , Hydronephrosis/surgery , Laparoscopy/methods , Nephrectomy/methods , Polycystic Kidney Diseases/surgery , Pyelonephritis/surgery , Follow-Up Studies , Prospective Studies , Tomography, X-Ray Computed , Treatment Outcome