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1.
Article in English | WPRIM | ID: wpr-914754

ABSTRACT

Cardiac magnetic resonance imaging (MRI) serves as a clinical gold-standard noninvasive imaging technique for the assessment of global and regional cardiac function. Conventional cardiac MRI is limited by the long acquisition time, the need for ECG gating and/or long breathhold, and insufficient spatiotemporal resolution. Real-time cardiac cine MRI refers to high spatiotemporal cardiac imaging using data acquired continuously without synchronization or binning, and therefore of potential interest in overcoming the limitations of conventional cardiac MRI. Novel acquisition and reconstruction techniques must be employed to facilitate real-time cardiac MRI. The goal of this study is to discuss methods that have been developed for realtime cardiac MRI. In particular, we classified existing techniques into two categories based on the use of non-iterative and iterative reconstruction. In addition, we present several research trends in this direction, including deep learning-based image reconstruction and other advanced real-time cardiac MRI strategies that reconstruct images acquired from real-time free-breathing techniques.

2.
Chinese Journal of Dermatology ; (12): 920-923, 2021.
Article in Chinese | WPRIM | ID: wpr-911532

ABSTRACT

Nail unit tumors are a group of rare tumors only occurring in the nail unit, including onychopapilloma, onychomatricoma, onychocytic matricoma, onycholemmal carcinoma, and so on. These tumors have specific clinical manifestations and pathological features due to their special anatomical locations. This review focuses on clinical manifestations, histopathological characteristics and treatment of the above tumors.

3.
Article in Chinese | WPRIM | ID: wpr-907442

ABSTRACT

Follicular thyroid carcinoma(FTC) is a differentiated thyroid carcinoma originated from thyroid follicular cells. The sensitivity and specificity of ultrasound classification and scoring systems in diagnosis of follicular carcinoma are insufficient. Ultrasound guided fine needle aspiration(US-FNA) can screen but cannot diagnose FTC. Core needle biology(CNB) can reduce repeated FNA and unnecessary operations, and improve the diagnostic accuracy of FN patients, but CNB still has many controversies. Ultrasound guided FNA combined with gene detection (such as RAS) can significantly improve the diagnostic accuracy of follicular neoplasm. In recent years, artificial intelligence assisted diagnosis has shown high specificity in distinguishing FTC from follicular thyroid adenoma (FTA), which is conducive to the standardized treatment of thyroid follicular neoplasm. In this paper, the research progress of ultrasound based in diagnosis of FTC was reviewed.

4.
Chinese Journal of Endemiology ; (12): 179-185, 2021.
Article in Chinese | WPRIM | ID: wpr-883689

ABSTRACT

Objective:To investigate the characteristics and significance of insulin-like growth factor 1(IGF- 1) and insulin-like growth factor binding protein 2 (IGFBP2) expressions in ankle cartilage of patients with Kashin-Beck disease (KBD).Methods:In this case-control study, 10 KBD patients who were hospitalized in the Department of Orthopedics of Shaanxi Provincial People's Hospital from January 2010 to December 2016 were selected as KBD group, and 10 patients with ankle fracture caused by trauma but without talus injury during the same period were selected as control group, the cartilage tissues of the two groups were collected. IGF-1, IGFBP2 positive cells, the mRNA and protein expressions of IGF-1, IGFBP2 in the cartilage tissues were detected by immunohistochemistry, real-time fluorescent quantitative PCR and Western blotting, respectively. According to the expressions of IGF-1 and IGFBP2 in ankle cartilage of KBD patients, a patient with amputation caused by trauma was selected in Shaanxi Provincial People's Hospital, and ankle joint cartilage was taken to prepare chondrocytes for in vitro cell verification experiments. The chondrocyte were divided into control group (0 ng/ml T-2 toxin), T-2 treatment group (20 ng/ml T-2 toxin) and T-2+ IGFBP2 silenced group (20 ng/ml T-2 toxin+ 50 nmol/L IGFBP2 siRNA), the MTT method and dimethyl methylene blue staining were used to detect the activity of chondrocyte and the secretion of sulfated glycosaminoglycan (sGAG). Results:In the control group and the KBD group, the number of IGF-1[(47.26 ± 8.97), (68.15 ± 7.42) cells] and IGFBP2 positive cells [(27.56 ± 5.40), (71.85 ± 7.62) cells] in the cartilage tissues were significantly different ( t = 4.487, 9.402, P < 0.01). Compared with the control group, the IGF-1, IGFBP2 mRNA and protein expression levels in KBD group were significantly higher, the differences were significantly different ( t = 3.340, 20.700, 4.684, 8.699, P < 0.05 or < 0.01). In cell experiment, the chondrocyte activitives and sGAG contents of the control group, T-2 treatment group, and T-2+ IGFBP2 silenced group were significantly different ( F = 226.70, 80.66, P < 0.01); among them, the cell activitives and sGAG contents of the T-2 treatment group and T-2+ IGFBP2 silenced group were lower than those of control group ( P < 0.05), and the T-2+ IGFBP2 silenced group were higher than those of the T-2 treatment group ( P < 0.05). Conclusions:The expressions of IGF-1 and IGFBP2 in the ankle cartilage of KBD patients are significantly higher. Silencing IGFBP2 gene can reduce the inhibitory effect of T-2 toxin on chondrocyte activity and the secretion of sGAG.

5.
China Pharmacy ; (12): 451-456, 2020.
Article in Chinese | WPRIM | ID: wpr-817291

ABSTRACT

OBJECTIVE:To study the composition and contents of flavonoids chemical components in waste material during industrialization of Pueraria thomsonii resources,and to provide reference for comprehensive development and reasonable utilization of the variety. METHODS :Using“No. 2 Gange”of P. thomsonii from Jiangxi as objects ,UPLC-Q-TOF-MS and HPLC method were adopted to detect the components and contents of flavonoids in the root (with or without cortex ),cortex,flower, fibrous root ,stem,head and dregs (with or without cortex )of P. thomsonii as well as dry matter of industrial wastewater (with or without cortex )after precipitation of pueraria powder. RESULTS :The linearity ,precision,repeatability,stability and recovery of the established method for content determination of 7 flavonoids(puerarin,daidzin,iridoxine-7-O-xylose glucoside ,genistin, iridin,daidzein and kakkalide )were all in line with the requirements. Totally 12 kinds of flavonoids were identified ,among which the flavonoids in the root ,cortex,stem,fibrous root ,head and dregs of P. thomsonii as well as dry matter of industrial wastewater were the same ,mainly were puerarin ,daidzin,genistein,daidzein and malonyl-daidzein. The flower of P. thomsonii mainly included iridoxine- 7-O-xylose glucoside ,genistin,iridin,kakkalide,6″-O-xylosyldaidzein,but the components as puerarin , daidzin and its aglycone were not be detected. The content of puerarin in the head of P. thomsonii was the highest (5.765%). The contents of puerarin in root and dregs of P. thomsonii as well as dry matter of industrial waste-water in samples with cortex were all higher than in corresponding peeled sample. CONCLUSIONS :The waste material from the industrialization of P. thomsonii resources contains a lot of flavonoids with rich species and high content ,and can be used as an important raw material for obtaining flavonoids such as puerarin.

6.
Article in Chinese | WPRIM | ID: wpr-866080

ABSTRACT

Objective:To detect the expression levels of interleukin (IL)-1β, insulin-like growth factors (IGF)-1 in serum and synovial fluid of patients with Kaschin-Beck disease (KBD) and osteoarthritis (OA) and analyze the relationship between IL-1β, IGF-1 levels and visual analogue scale (VAS) score.Methods:From January 2010 to December 2016, 60 patients visited the department of orthopedics of Shaanxi Provincial People's Hospital were selected, included 20 patients with KBD (arthroscopic debridement of ankle), 20 patients with OA (arthroscopic debridement of ankle), and 20 patients with ankle fracture (no talus injury) as control group. The peripheral blood and synovial fluid samples from the patients were collected. Enzyme-linked immunosorbent assay was used to detect the expression levels of IL-1β, IGF-1 in serum and synovial fluid. In each group, VAS score was calculated pre-operative and post-operative at 3, 7, 14 and 28 d. The relationship between IL-1β, IGF-1 levels and VAS score was evaluated by correlation analysis.Results:Synovial fluid IL-1β and IGF-1 levels in the KBD and OA groups were (67.32 ± 6.22), (56.46 ± 5.43) and (24.36 ± 6.22), (21.45 ± 4.35) pg/ml, respectively, which were higher than those in the control group [(27.01 ± 3.15), (10.21 ± 2.50) pg/ml, P < 0.05]. Meanwhile, serum IL-1β and IGF-1 levels in the KBD and OA groups were higher than those in the control group ( P < 0.05). Pearson correlation analysis showed that the expression levels of IL-1β and IGF-1 in serum pre-operative and post-operative at 3, 7, 14 and 28 d were positively correlated with VAS score in KBD and OA groups, respectively ( r = 0.427, 0.502, 0.562, 0.628, P < 0.05). Conclusion:The levels of IL-1β and IGF-1 in synovial fluid from ankle joints and serum are significantly increased in KBD group and OA group, and the levels of IL-1β and IGF-1 in serum are positively correlated with VAS score, respectively.

7.
Article in English | WPRIM | ID: wpr-829026

ABSTRACT

BRAF is a serine/threonine kinase that harbors activating mutations in ∼7% of human malignancies and ∼60% of melanomas. Despite initial clinical responses to BRAF inhibitors, patients frequently develop drug resistance. To identify candidate therapeutic targets for BRAF inhibitor resistant melanoma, we conduct CRISPR screens in melanoma cells harboring an activating BRAF mutation that had also acquired resistance to BRAF inhibitors. To investigate the mechanisms and pathways enabling resistance to BRAF inhibitors in melanomas, we integrate expression, ATAC-seq, and CRISPR screen data. We identify the JUN family transcription factors and the ETS family transcription factor ETV5 as key regulators of CDK6, which together enable resistance to BRAF inhibitors in melanoma cells. Our findings reveal genes contributing to resistance to a selective BRAF inhibitor PLX4720, providing new insights into gene regulation in BRAF inhibitor resistant melanoma cells.

8.
China Pharmacy ; (12): 3404-3407, 2019.
Article in Chinese | WPRIM | ID: wpr-817403

ABSTRACT

OBJECTIVE: To provide reference for the development and sustainable utilization of TCM industry with regional characteristics. METHODS: Taking Shicheng county of Jiangxi province as an example, field investigation was carried out on Paeoniaceae suffruticosa planting base in the county, a few representative P. suffruticosa planting bases in the county were selected as sample points, and GPS was used to locate and record the location information of sample points. The remote sensing image was automatically extracted by computer, the artificial visual interpretation method was used to get P. suffruticosa planting area image. Then combined with the field inspection verification, P. suffruticosa planting area was obtained, and the investigation results were analyzed. RESULTS: Through remote sensing interpretation of the planting area of P. suffruticosa in Shicheng county, it was obtained that the total planting area of P. suffruticosa in Shicheng county was 42 597 951.505 square meters (63 864.995 mu) in 2018, accounting for about 33% of the cultivated land area, which was 42.12% higher than the conventional planting area of 44 936 mu in 2013. The distribution of P. suffruticosa planting in Shicheng county was mainly concentrated in Xiaosong town and Fengshan town in the north, and Daqu town and Pingshan town in the south. CONCLUSIONS: Remote sensing technology has the advantages of fast data acquisition, large amount of information, high accuracy and strong timeliness, which greatly avoids the complexity of work, saves a lot of manpower and material resources. The technology can provide technology support for obtaining the regional planting area and distribution information of TCM such as P. suffruticosa, dynamic monitoring, scientific warning of the market status of TCM, and guiding the large-scale, standardized and intensive development of TCM cultivation.

9.
Article in Chinese | WPRIM | ID: wpr-733930

ABSTRACT

Objective To explore the clinical effect of dynamic enhancement combined with diffusion -weighted magnetic resonance imaging( MRI) in the diagnosis of benign and malignant breast lesions. Methods From January 2017 to January 2018,100 patients with breast lesions in Zhoushan Hospital were selected in the study. The patients received MR-DWI and DCE-MRI inspection,and the results were compared with the pathological verification results. Results The ADC value of benign breast lesions was (1. 65 ± 0. 24) × 10 -3 mm2/s. The ADC value of malignant breast lesions was (1. 17 ± 0. 17) × 10 -3 mm2/s,and there was statistically significant difference in ADC value between patients with benign and malignant breast lesions(t=5. 021,P<0. 05). The number of type Ⅰ,typeⅡ and type Ⅲ curve cases of 88 patients with benign lesions was 62 cases(70. 45%),18 cases(20. 45%) and 8 cases(9. 09%),respectively. The number of patients with type Ⅰ,type Ⅱ and type Ⅲ curve of malignant lesion was 3 cases(15. 00%),5 cases(25. 00%) and 12 cases(60. 00%),respectively. For dynamic enhancement type Ⅰand type Ⅲ curve in breast benign and malignant lesions,the difference was statistically significant(χ2 =8. 254,P<0. 05). The area under the curve of the joint diagnosis compared with the simple use of ADC and DEC-MRI,the difference was statistically significant(χ2 =6. 032,P<0. 05). The ADC compared with DEC-the area under the curve of MRI in the diagnosis had no obvious difference(χ2 =5. 221,P>5. 221). Conclusion The integrated use of DWI and DCE-MRI can lay the solid data for the diagnosis of breast malignant tumor,and effectively strengthen the diagnostic sensitivity and specificity,and make clinical intervention and clinical treatment easily.

10.
Article in Chinese | WPRIM | ID: wpr-753311

ABSTRACT

Objective To systematically evaluate the effects of new antiepileptic drugs on bone metabolism in children. Methods Chinese and English databases such as Pubmed, Cochrance Library, China Knowledge Network, Wanfang Knowledge Service Platform, and Weipu Chinese Journal Full-text Database were searched. The search time was limited for each database from the first issue to August 2018, and new anti-epileptic clinical trial of the effects of drugs on bone metabolism in children was selected. The literature was independently read by two reviewers. The effect size was extracted according to the inclusion and exclusion criteria, and the quality of the study was evaluated. The system evaluation (Meta analysis) was performed using Revman 5.3 software. Results A total of 526 cases in the experimental group (children taking antiepileptic drugs) and 478 cases in the control group (healthy children or children without taking antiepileptic drugs) were included in 16 pieces of literatures. Meta-analysis showed that there was no significant difference in bone mineral density between experimental group and control group ( SMD=-0.03, 95% CI :-0.17-0.10, P=0.62). As for bone turnover markers, there was significant differences in serum total alkaline phosphatase (ALP) between the two groups ( SMD=0.19, 95% CI : 0.03- 0.36, P=0.02), while there were no significant differences in serum calcium, serum phosphorus, serum bone specific alkaline phosphatase, serum vitamin D and the ratio of deoxypyridinoline andcreatinine (DPD/Cr). Conclusions The new antiepileptic drugs have no effect on bone mineral density. In the aspect of bone turnover markers, the serum total alkaline phosphatase of the children taking the new antiepileptic drugs is higher, but has no effect on other bone turnover markers.

11.
Chinese Journal of Orthopaedics ; (12): 298-304, 2019.
Article in Chinese | WPRIM | ID: wpr-745400

ABSTRACT

Objective To investigate the therapeutic effect of anteromedial ankle approach for talus fracture.Methods From January 2012 to October 2018,the data of 28 cases of talus fracture treated by anteromedial ankle approach were retrospectively analyzed,including 26 males and 2 females,aged 24-61 years with an average of 38.6 years.All 25 cases of closed injuries and 3 cases of open injuries were fresh injuries.There were 16 cases of traffic injuries,8 falling injuries,2 heavy object injuries and 2 sprains.Among the 28 patients,17 were talus neck fractures,and according to Hawkins talus neck fracture classification,there were 1 case of type Ⅰ,12 type Ⅱ,and 4 type Ⅲ.There were 11 cases of talus fracture,which were classified according to Sneppen talus fracture types:2 cases of type Ⅰ,8 cases of type Ⅱ and 1 case of type Ⅴ.Among them,2 cases of talus neck fracture complicated with T12 vertebral body fractures and 2 cases complicated with calcaneal fractures.The time from injury to operation for 3 patients with open fracture was 3-6 hours.25 cases of closed fracture injuries took 2-10 hours to operate,with an average time of 5.6 hours.All patients were fixed with cannulated screws through the anteromedial ankle approach.The weight-bearing time and strength of lower limbs were determined according to fracture healing after surgery.The ankle function was evaluated by American Orthopaedic Foot and Ankle Society (AOFAS) Score.Results All 28 patients were followed up for 23 to 82 months,with an average of 37.5 months.All fractures healed.The healing time of talus neck fracture was 3.5-8 months,with an average of 5 months.The healing time of talus fracture was 3-7 months,averaging 4.5 months.At the latest follow-up,AOFAS score ranged from 68 to 100,with an average of 82.5 points,including excellent in 15 cases,good in 8 cases,fair in 4 cases and poor in 1 case,with the excellent and good rate of 82.1% (23/28).There were no signs of fracture displacement,malunion,loosening and prolapse of internal fixation,fracture and ischemic necrosis of talus after operation.Traumatic arthritis occurred in 9 patients,with an incidence rate of 32.1% (9/28).Tibial joint was involved in 5 cases,talus joint in 3 cases,tibialis in 1 case and talus joint in 1 case.Among them,traumatic arthritis occurred in 2 cases of open injury.Nine patients (32.1%) suffered from traumatic arthritis 6-10 months after operation,with an average of 8 months.According to conservative treatments such as weight control,ankle immobilization,physiotherapy,anti-inflammatory and analgesic,nutrition of articular cartilage drugs,joint traction and plasty were given.The patients' conditions improved to different degrees and could tolerate walking and normal life and work.Conclusion The anteromedial ankle approach has the advantages of minimal vessel injuries,clear exposure for direct reduction,low rate of necrosis of talus and satisfactory curative effect.

12.
Article in Chinese | WPRIM | ID: wpr-801598

ABSTRACT

Objective@#To investigate the effect of diabetes on the risk of stroke recurrence within 1 year after onset of ischemic stroke.@*Methods@#Patients with ischemic stroke admitted to the Department of Neurology, the Second Hospital of Hebei Medical University from October 2016 to August 2017 were enrolled prospectively. Their baseline clinical data were collected and they were followed up for one year. The risk factors for ischemic stroke in recurrence group and non-recurrence group were compared. Cox proportional hazard regression model was used to determine the independent risk factors for ischemic stroke recurrence. Kaplan-Meier survival analysis was used to explore the impact of risk factors on the risk of stroke recurrence.@*Results@#A total of 1 436 patients with ischemic stroke were included. During the follow-up of 1 year, a total of 183 patients had recurrence (12.74%). There were significant differences in the proportion of patients with diabetes, atrial fibrillation, hyperhomocysteinemia, oral antiplatelet drugs, and statins after discharge, and baseline fasting blood glucose level between the recurrence and the non-recurrence group (all P<0.05). Multivariate Cox proportional hazards analysis showed that diabetes mellitus (hazard ratio [HR] 1.574, 95% confidence interval [CI] 1.161-2.134; P=0.003) was an independent risk factor for stroke recurrence. Taking statins (HR 0.686, 95% CI 0.481-0.979; P=0.038) and antiplatelet agents (HR 0.678, 95% CI 0.467-0.983; P=0.041) after discharge were the independent protective factors for ischemic stroke recurrence. Kaplan-Meier survival analysis showed that the recurrence rate of ischemic stroke in patients with diabetes was significantly higher than that in those without diabetes (log-rank test, P=0.003). The recurrence rate of stroke in patients taking statins and antiplatelet drugs was significantly lower than that in patients who did not take the corresponding drugs (log-rank test, all P<0.001).@*Conclusions@#Diabetes is an independent risk factor for ischemic stroke recurrence, and taking statins and antiplatelet drugs are the independent protective factors for ischemic stroke recurrence.

13.
Article in Chinese | WPRIM | ID: wpr-799850

ABSTRACT

Nitrous oxide (N2O) is an anesthetic which is also known to have abuse potential. Nitrous oxide-induced disease is occasionally encountered in the clinic, and there have been only several case reports about nitrous oxide-induced disease. In this article we review the reported cases of severe nerve injury following N2O abuse.

14.
Article in Chinese | WPRIM | ID: wpr-824774

ABSTRACT

Nitrous oxide (N2O) is an anesthetic which is also known to have abuse potential.Nitrous oxide-induced disease is occasionally encountered in the clinic,and there have been only several case reports about nitrous oxide-induced disease.In this article we review the reported cases of severe nerve injury following N2O abuse.

15.
Article in Chinese | WPRIM | ID: wpr-805588

ABSTRACT

Objective@#To understand the status quo of quality of work life and turnover intention of nurses, and to explore the correlation between them, so as to provide scientific basis for formulating nursing intervention measures to improve quality of life and reduce turnover intention.@*Methods@#In December 2018, Random sampling method was used to select 400 nurses from a third-class hospital as the subjects of investigation. The quality of life of nurses was assessed by the quality of work life scale. The turnover intention of nurses was assessed by the turnover intention scale.@*Results@#Nurses' quality of work life was average 2.97±0.59 points, 2.78±0.60 points for job security, 2.61±0.66 points for work welfare, 3.11±0.70 points for job change, 3.34±0.71 points for self-growth, 2.97±0.63 points for environmental support, 2.51±0.80 points for promotion system, 3.41±0.68 points for interpersonal interaction and 3.01±0.72 points for decision-making. Nurses' turnover intention was average 2.46 points. The eight dimensions of quality of work life were negatively correlated with turnover intention I (the possibility of resigning from the present job) and II (the motivation to seek other jobs) (P<0.05) , but not with turnover intention III (the possibility of obtaining external work) (P>0.05) . Multivariate regression analysis showed that age, nurse-job seniority, annual income and self-growth, job change, environmental support, job security and job welfare were negatively correlated with turnover intention I and II (P<0.05) , while night shift frequency was positively correlated with turnover intention I and turnover intention II (P<0.05) .@*Conclusion@#The quality of nursing staff's work life is low, which is closely related to their turnover intention. Managers should take targeted measures in some aspects such as environ mental support and promotion system to improve the quality of nursing staff's work life and reduce their turnover intention.

16.
Chinese Journal of Oncology ; (12): 373-377, 2019.
Article in Chinese | WPRIM | ID: wpr-805236

ABSTRACT

Objective@#To investigate the correlation between cervical lymph node skip metastasis with ultrasonographic characteristics of papillary thyroid micro- carcinoma (PTMC).@*Methods@#We reviewed ultrasonographic features of 385 primary PTMC and cervical lymph node metastasis, confirmed by pathology in Tianjin Medical University Cancer Institute and Hospital, to evaluate the efficacy of ultrasonography in the diagnosis of cervical lymph node metastasis of PTMC patients. The relationship between ultrasonographic features of primary lesions and skip metastasis of cervical lymph nodes was analyzed by χ2 test and multiple factor Cox regression.@*Results@#Among the 385 cases of PTMC patients with cervical lymph node metastasis, 231 cases were central lymph node metastasis alone, 31 cases were lateral cervical lymph node metastasis alone, 123 cases were both central and lateral cervical lymph node metastasis. Among the 354 cases without skip metastasis of cervical lymph nodes, 48 cases were level Ⅱ, 92 cases were level Ⅲ, 83 cases were level Ⅳ, 9 cases were level Ⅴ, 354 cases were level Ⅵ. Among the 31 cases with skipping metastasis of cervical lymph nodes, 12 cases were level Ⅱ, 14 cases were level Ⅲ, 14 cases were level Ⅳ, 1 case was level Ⅴ. The sensitivity and specificity of preoperative ultrasonography in the diagnosis of central cervical lymph node metastasis were 46.3% and 66.7%, respectively, and those of lateral cervical lymph node were 91.0% and 87.8%, respectively. Univariate analysis showed that the abutment/perimeter, diameter and location of PTMC were significantly associated with skip metastasis (P<0.05), multivariate analysis showed that abutment/perimeter and location of PTMC were significantly associated with skip metastasis (P<0.05).@*Conclusions@#The sensitivity and specificity of preoperative ultrasound diagnosis for lateral cervical lymph node metastasis of PTMC is higher than that of central metastasis. PTMC with abutment/perimeter ≥1/4 and upper portion location are prone to skip metastasis.

17.
Article in Chinese | WPRIM | ID: wpr-706786

ABSTRACT

Objective:To compare the relationship between the operative strategies and clinical outcomes of type Ⅲ and Ⅳ hilar chol-angiocarcinomas(HCs).Methods:We retrospectively analyzed the clinical data and long-term outcomes for 50 cases of type Ⅲ and Ⅳ HC that underwent surgery at the Tianjin Medical University Cancer Hospital.Results:Fifty patients were followed up and the median follow-up duration was 27 months.The hilar limited hepatectomy group included 13 cases;the median disease-free survival was 6 months,and 1-and 2-year disease-free survival rates were 30.8% and 23.1%,respectively.The median overall survival was 20 months, and the 1-and 2-year overall survival rates were 76.9% and 38.5%,respectively.The extended hepatectomy group included 37 cases;the median disease-free survival was 14 months,and 1-and 2-year disease-free survival rates were 59.5% and 32.4%,respectively.The median overall survival was 37 months,and the 1-and 2-year overall survival rates were 83.8% and 51.4%,respectively.Compared with the hilar limited hepatectomy group,the extended hepatectomy group had significantly longer median disease-free and overall survival(P<0.05).The 1-and 2-year disease-free and overall survival rates were higher for the extended hepatectomy group.There was no significant difference in morbidity and mortality between the two groups(P>0.05).Conclusions:Extended hepatectomy is a safe operation that delays recurrence at early time points and improves the prognosis for patients with type Ⅲ and Ⅳ HC.

18.
Article in Chinese | WPRIM | ID: wpr-706751

ABSTRACT

Recently,the incidence of papillary thyroid carcinoma(PTC)has been increasing yearly.Ultrasonography is considered the first tool in the screening and diagnosis of thyroid nodules.Ultrasound-guided fine needle aspiration(US-FNA)biopsy is an effective, minimally invasive intervention for the differential diagnosis of thyroid nodules before operation.The diagnosis of US-FNA is classified by the Bethesda diagnostic system. Although fine needle aspiration cytology has high sensitivity and specificity, unclear diagnoses, such as atypical follicular lesions,are still existed.US-FNA combined with genetic mutation analysis(BRAF,RAS,and RET/PTC rearrange-ment)for such atypical lesions(BethesdaⅢ-Ⅴ),as well as microRNA analysis,can significantly improve the diagnostic accuracy of in-definite nodules.This process facilitates standardized clinical management of benign and malignant thyroid nodules.

19.
Chinese Journal of Oncology ; (12): 196-200, 2018.
Article in Chinese | WPRIM | ID: wpr-806254

ABSTRACT

Objective@#To investigate the correlation between ultrasonographic features of papillary thyroid carcinoma and central cervical lymph node metastasis.@*Methods@#We retrospectively analyzed 486 patients with papillary thyroid carcinoma(PTC), pathologically confirmed after surgery in Tianjin Medical University Cancer Institute & Hospital. All patients were divided into central cervical lymph node metastasis group and non-metastasis group. No lateral cervical lymph node metastasis was found in preoperative ultrasonography and postoperative pathology. The characteristics of the ultrasound was observed and analyzed.@*Results@#297 out of 486 patients with papillary thyroid carcinomahad central metastasis, and the other 189 cases did not. Take pathology results as a standard, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate of preoperative ultrasound diagnosis in PTC patients with central cervical lymph node metastasis were 35.3%, 88.6%, 83.2%, 47.4%, 56.6%, respectively. Univariate analysis showed that multi-focus, taller-than-wide, diameter>1 cm, located in the lower pole, ill-defined margin, hypoechogenicity, micro-calcification, capsule invasion more than 1/4 perimeter of papillary thyroid carcinoma were significantly associated with central cervical lymph node metastasis (all P<0.05). Multivariate analysis showed that diameter>1 cm, micro-calcification, capsule invasion more than 1/4 perimeter of papillary thyroid carcinoma became independent risk factors of central cervical neck lymph node metastasis (all P<0.05).@*Conclusions@#Preoperative description of ultrasonographical features has important value to assess central cervical lymph node metastasis in patients with papillary thyroid carcinoma. More information could be provided for clinical treatment. When the papillary thyroid carcinoma presented as diameter>1 cm, micro-calcification, and capsule invasion more than 1/4 perimeter of, there will be a greater risk of central cervical lymph node metastasis, and we shall suggest prophylactic central lymph cervical node dissection.

20.
China Pharmacist ; (12): 432-434, 2018.
Article in Chinese | WPRIM | ID: wpr-705551

ABSTRACT

Objective:To observe the intervention effect of acarbose on cerebral arterial thrombosis complicated with impaired glu-cose tolerance(IGT).Methods: Totally 120 cases of IGT patients with ischemic stroke were randomly divided into the observation group (58 cases) and the control group(62 cases). The two groups were given the same basic treatment,while the observation group was treated with acarbose 50 mg,po,tid for 3 months additionally. Before and after the treatment,the levels of blood lipid and blood glucose,serum high-sensitivity C reactive protein(hsCRP) and carotid intima media thickness(IMT) and the other adverse drug reac-tions were detected in the two groups. After 6-month follow-up,the new incidence of IGT was compared between the groups.Results:After the treatment,2 hPG,HbAlc,hsCRP and the other indicators in the observation group were significantly improved when com-pared with those before the treatment(P<0.01 or P<0.05),while only hsCRP in the control group was significantly improved when compared with that before the treatment(P<0.05) and that in the observation group. 2 hPG,HbAlc,hsCRP,IMT and the other in-dicators in the observation group were significantly better than those in the control group(P<0.01 or P<0.05). There was no signifi-cant change in the level of blood lipid in the two groups. There was no adverse drug reaction during the treatment. After the 6-month follow-up,the new incidence of IGT in the observation group was 1.82%,which was significantly lower than that in the control group (7.27%,P<0.05).Conclusion: Among the patients with cerebral arterial thrombosis complicated with impaired glucose tolerance, the normal treatment measures plus acarbose can effectively delay carotid artery IMT incrassation and decrease the risk of cardiovascular events recurrence with better relative safety.

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