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China Pharmacy ; (12): 1697-1701, 2019.
Article in Chinese | WPRIM | ID: wpr-817124


OBJECTIVE: To evaluate the efficacy and safety of Yinxie capsules combined with Acitretin capsules in the treatment of psoriasis vulgaris in order to provide reference for clinical drug use. METHODS: Retrieved from PubMed, Embase, Cochrane Library, CBM, CNKI, VIP, Wanfang database, randomized controlled trials (RCTs) about Yinxie capsules combined with Acitretin capsules (trial group) vs. Acitretin capsules (control group) in the treatment of psoriasis vulgaris were collected. After literature screening, data extraction and quality evaluation with Cochrane 5.1.0 bias risk evaluation tool, Meta-analysis was performed by using Rev Man 5.3 software, and trial sequence analysis (TSA) was conducted with TSA 0.9 software. RESULTS: A total of 7 RCTs with 660 patients were included. Results of Meta-analysis showed that the total response rate [RR=1.15,95%CI(1.04, 1.28), P=0.007], the levels of IL-4 [SMD=0.85,95%CI(0.02, 1.68),P=0.04] and IL-10 [SMD=0.56,95%CI(0.28, 0.83), P<0.000 1] in trial group were significantly higher than control group. The psoriasis area and severity index score [MD=-2.34,95%CI(-2.77,  -1.91),P<0.000 01], incidence of dry eye [RR=0.32,95%CI(0.23, 0.45),P<0.001], dry skin [RR=0.47,95%CI(0.32, 0.71),P<0.001], folliculitis [RR=0.42,95%CI(0.30, 0.59),P<0.001], the elevation of ALT [RR=0.18,95%CI(0.05, 0.61),P=0.005] and hyperlipidemia [RR=0.48,95%CI(0.35, 0.65),P<0.001] in trial group were significantly lower than control group. There was no statistical significance in nose bleeding between 2 groups [RR=0.46,95%CI(0.16, 0.37),P=0.16]. TSA showed that the evidence of enhancing total response rate by Yinxie capsules combined with Acitretin capsules in the treatment of psoriasis vulgaris was reliable. CONCLUSIONS: Yinxie capsules combined with Acitretin capsules show good efficacy and safety for psoriasis vulgaris.

Article in Chinese | WPRIM | ID: wpr-574268


[Objective] To observe the therapeutic effect of oral use of heat-clearing, damp-removing and toxicity-clearing herbal medicine combined with ultrasonic wave and herbal medicine mask treatment in treating acne simplex (AS). [Methods] Two hundred and ten cases of AS were randomized into groups A and B. Group A ( n=113) was treated with modified Yinchenhao Decoction and Qingfei Decoction for oral use and added with ultrasonic wave and mask prepared with herbal medicine including Borneolum Syntheticum, Flos Lonicerae, Radix Scutellariae, Radix Salviae Miltiorrhizae, Fructus Forsythiae; group B ( n=97) was treated with metronidazole 0.2 g, tid, and vitamin Bg 20mg, tid, as well as erythromycin ointment for external application. After a 4-week treatment, the therapeutic effect was compared. [Results] The total effective rale was 80.6% in group A and 41.3% in group B, and the markedly effective rate was 50.5% in group A and 28.9% in group B, the difference being significant (P

Article in Chinese | WPRIM | ID: wpr-574797


[Objective] To observe the therapeutic effect of Qingfei Jianpi Decoction (QJD) for the treatment of acne vulgaris (AV) . [Methods] One hundred and five cases of AV were randomized into two groups: group A (n =64) was treated with QJD, a prescription medicine mainly composed of Herba Houttuyniae, Cortex Lycii, Cortex Moutan, Radix Scutellariae, Radix Fici Simplicissimae, Radix Flemingiae Philippinensis, Rhizoma Atractylodis Macrocephalae, Poria, etc. , and group B (n=41) with tetracycline for 4 weeks. After treatment, the therapeutic effect, changes of facial lesion and signs, and side effects were observed. A 3-month follow-up was made for the cured patients to investigate the recurrence rate. [Results] Facial lesion and seborrheic degree were relieved in group A, the difference being significant as compared with those before treatment (P0.05 ) . The therapeutic effect was better in group A than that in group B (P

Article in Chinese | WPRIM | ID: wpr-575734


【Objective】To observe the effect of treating psoriasis vulgari(PV)by solving disorders of blood system.【Methods】Two hundred and six patients with PV were randomized into groups A and B.Group B(n=70)was treated with oral use of clarityne,vitamin C,Tripterygium Glycosides Tablets,and roxithromycin,as well as external application of sulphur ointment or clobetasol propionate ointment.Group A(n=136)was additionally treated with basic recipe(composed of Rhizoma Smilacis Glabrae,Radix Isatidis,Folium Isatidis,Radix Rehmanniae,Cortex Moutan,Herba Hedyotis Diffusae,Herba Lobeliae Chinensis,Nidus Vespae,Rhizoma Chuanxiong,Rhizoma Alismatis,Herba Plataginis,Fructus Kochiae,Cortex Dictamni,Radix Glycyrrhizac).Meanwhile,patients in group A were classified into 3 syndrome patterns of blood heat,blood stasis and blood dryness,and treated with corresponding recipes.After three courses of treatment(3 month in total),the therapeutic effect,as well as the side effects and recurrence rate was evaluated in the two groups.【Results】In group A,71 patients were cured,22 markedly effective,26 effective,17 ineffective and the total effective rate was 87.50%,and 23,15,21,11 and 84.28% in group B,respectively.The therapeutic effect in group A was superior to that in group B(P