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Article in Chinese | WPRIM | ID: wpr-696983


Objective To explore the use double butterfly wings raised platform method for patients with fixed effects of abdominal cavity drainage tube. Methods For the treatment of gynecological surgery in the hospital and abdominal cavity drainage tube of the clinical data of 245 patients were analyzed, and on October 31, 2016 as the cut-off time was divided into the control group of 119 cases and observation group of 126 cases in control group were treated by conventional methods for abdominal cavity drainage tube, observation group of patients with double butterfly wings raised platform in the abdominal cavity drainage tube was fixed, and comparative analysis of two groups patients with abdominal cavity drainage tube drainage effect, pull the pain caused by fixed effects, and the drainage tube. Results The observation group and the control group there was no statistically significant difference total indwelling time, pain score, to observe group posted time (2.00±1.36), respectively (3.00± 0.62), the control group, respectively (5.00 ± 1.89), (0.35 ± 0.05) points, two groups compare the difference was statistically significant (t=7.883,3.457, P<0.01), the observation group without pipe of 100.0%(126/126), the control group without pipe of 89.9%(107/119), part of the pipe of 7.6%(9/119), completely pipe of 2.5% (3/119), two groups compare the difference was statistically significant (Z=-15.305, P<0.01). Conclusion Compared with the conventional abdominal cavity drainage tube fixed method, double butterfly wings raised platform method fixed abdominal cavity drainage tube fixed effect is better, can significantly ease the pain of patients suffer, saved the time nursing.

Article in Chinese | WPRIM | ID: wpr-696681


Objective To evaluate the long-term efficacy of neonatal immunoprophylaxis in children born from mothers infected with hepatitis B virus (HBV),and to clarify whether a booster vaccination is required.Methods Totally 252 children of HBV infected mothers,who were negative for hepatitis B surface antigen (HBsAg) tested in Nanjing Drum Tower Hospital in 2012,were enrolled to participate in this study from July to September,2017.Revaccination of hepatitis B vaccine was recorded and other relevant informations were collected.HBV serologic markers were detected in each child.Results Totally 198 children (78.6%) were followed up.They were (8.4 ± 2.2) years old and 112 cases were boys.All 198 children were negative for both HBsAg and hepatitis B core antibody (anti-HBc).The overall positive rate of hepatitis B surface antibody (anti-HBs) (≥ 10 IU/L) was 65.7%.During period of 2012 to 2017,53 children were boosted with hepatitis B vaccine.Their median anti-HBs titer in 2017 was higher than that in 2012 (327.95 IU/L vs.158.01 IU/L),and the difference was significant (Z =-4.480,P <0.05).The other 145 children were not revaccinated,their median anti-HBs titer was decreased from 214.19 IU/L in 2012 to 70.49 IU/L in 2017,and the difference was significant (Z =-6.575,P < 0.05).Of 145 children who were not revaccinated,25 cases had anti-HBs levels < 10 IU/L and 120 cases ≥ 10 IU/L in 2012,and the other 47 cases also showed the antibody < 10 IU/L in 2017,but none of them was infected with HBV.Conclusions Neonatal immunoprophylaxis in infants from HBV-infected can provide long-term protection against hepatitis B.The children with anti-HBs < 10 IU/L are still immune to HBV and booster vaccination for them seems unnecessary.

Article in Chinese | WPRIM | ID: wpr-466750


Objective To explore the expression levels of immune-related microRNA-146b (miR-146b),microRNA-155 (miR-155) and microRNA-30b(miR-30b) in human breast milk and its relationship with maternal and infant's health.Methods One hundred and thirty-four mothers and their infants from obstetrical department were recruited in the study after delivery.The subjects were divided into 2 groups,breast feeding group(n =86) and formula-feeding group(n =48),and were followed up 3 months after delivery.Breast milk samples were collected at 2-5 days after delivery(colostrum) and 3 months after delivery(mature milk).The expression levels of microRNAs in milk samples were detected by real-time PCR.The relationship between levels of microRNAs and maternal and infant-related factors was analyzed.Results 1.MiR-146b,miR-155 and miR-30b expressions were abundant both in human colostrums (5.950 ± 0.823,3.899 ± 0.920,4.057 ± 0.604) and mature milk (4.840 ± 0.805,2.128 ± 0.969,4.929 ± 0.566).The levels of miR-146b and miR-155 were higher in colostrum than that of mature milk (t =7.716,10.215,all P < 0.01),while the level of miR-30b was higher in mature milk than that of colostrums(t =-8.626,P < 0.0l).2.Additionally,the level of miR-30b was negatively correlated with maternal pre-pregnancy body mass index (r =-0.298,P < 0.01).3.The levels of miR-146b and miR-30b were higher in mothers giving birth by vaginal delivery than those who underwent cesarean section(t =2.356,3.108,all P <0.05).4.The levels of miR-146b and miR-155 were higher in colostrum-fed girls than boys (t =-2.204,-2.985,all P < 0.05).5.The level of miR-146b in mature milk was negatively correlated with 3-month-old infant' s Z score of body weight (r =-0.425,P < 0.05) and body length (r =-0.569,P < 0.01).6.During follow-up,the incidence of baby eczema in breast feeding group (8.82%,3/34 cases) was lower than that in formula milk feeding group(29.17%,14/48 cases) (x2 =5.012,P =0.025).Conclusions The levels of immunocompetent microRNAs in human milk are influenced by the lactation period,maternal prepregnancy body mass index,mode of delivery and infant sex.The immune-related microRNAs in human milk could be involved in the regulation of infant's immunity and growth.