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1.
Article in Chinese | WPRIM | ID: wpr-909822

ABSTRACT

Objective:To investigate the epidemiological and etiological characteristics of hand-feet-mouth disease (HFMD) in Dali Bai Autonomous Prefecture and to provide scientific evidence for the prevention of HFMD.Methods:The HFMD cases during January 2015 to December 2019 in Dali Bai Autonomous Prefecture were collected through the Chinese Information System for Disease Control and Prevention. The demographic data, incidence rate of HFMD and epidemiological characteristics were analysed. Coxsackie virus A16(CoxA16), enterovirus 71(EV71) and other enterovirus nucleic acid in stool samples of HFMD patients were detected by real-time reverse transcription polymerase chain reaction. Chi-square test was used as statistical method.Results:From 2015 to 2019, 30 730 cases of HFMD were reported in Dali Bai Autonomous Prefecture. The annual incidence rate was 171.50/100 000, and the incidence rate was on rise from 2016 to 2019. There were 24(0.08%) severe cases. Yongping County, Binchuan County and Dali City were with the top three average annual incidence rate. The peak incidence was from June to July in summer, 9 168 cases (29.83%) were reported. The peak incidence was from September to October in autumn, 5 988 cases (19.49%) were reported. The epidemic intensity in summer was higher than that in autumn. Among 30 730 cases, there were 17 373 males and 13 357 females. The annual incidence rate of male patients was 120.29/100 000, and that of female was 75.83/100 000. The difference was statistically significant ( χ2=1 637.467, P<0.01). The highest incidence was in infancy (one to <three years old), followed by preschool stage (three to <six years old) and the incidence rate was 4 158.96/100 000 and 1 953.11/100 000, respectively. From infancy, the incidence decreased with age. Severe cases concentrated in infancy with a total of 16 cases, accounting for 66.67% of severe cases. The affected population was mainly scattered children, and a total of 20 516 cases (66.76%) were reported. Among the 1 294 laboratory confirmed cases, 792 (61.21%) were CoxA16 infected cases, 320 (24.73%) were EV71 infected cases, and 182(14.06%) were other enterovirus infected cases. Conclusions:The incidence of HFMD in Dali Bai Autonomous Prefecture has obvious seasonal, age and population characteristics. It is necessary to strengthen the cooperation among departments, health education and strict implementation of prevention and control measures in order to reduce the incidence and improve the ability of early identification and treatment of severe cases.

2.
Article in Chinese | WPRIM | ID: wpr-886532

ABSTRACT

@#Objective    To determine the clinical efficacy of transapical transcatheter mitral valve-in-valve treatment for patients with deteriorated mitral bioprosthesis after aortic-mitral double valve replacement. Methods    The clinical data of 9 patients who underwent transapical transcatheter mitral valve-in-valve implantation after aortic-mitral double valve replacement due to mitral bioprosthesis deterioration from May 2020 to January 2021 in our hospital were retrospectively analyzed, including 4 males and 5 females with a mean age of 72.44±7.57 years. Results    Surgeries were performed successfully in all patients with no conversion to median sternotomy. The mean procedural time was 101.33±48.49 min, the mechanical ventilation time was 23.11±26.54 h, the ICU stay was 1.89±1.05 d and the postoperative hospital stay was 6.11±2.02 d. Residual mild mitral regurgitation was only observed in 1 patient. Only 1 patient needed postoperative blood transfusion. No major complications were observed in all patients. There was no death in postoperative 90 days. Conclusion    For patients with deteriorated mitral bioprosthesis after aortic-mitral double valve replacement, transapical transcatheter mitral valve-in-valve implantation achieves good clinical results and effectively  improves the hemodynamics without increasing the risk of postoperative left ventricular outflow tract obstruction. The surgery is feasible and effective.

3.
Article in Chinese | WPRIM | ID: wpr-881239

ABSTRACT

@#Objective    To investigate the effectiveness and safety of totally endoscopic transmitral myectomy (TETM) for hypertrophic obstructive cardiomyopathy (HOCM), comparing with traditional sternotomy modified Morrow procedure (SMMP). Methods    Thirty-eight patients with HOCM who needed surgical intervention were selected from our hospital in 2019, including 14 males and 24 females, with an average age of 56 (44-68) years. According to the operation method, they were divided into a TETM group (n=18) and a SMMP group (n=20). Appropriate patients  were screened by propensity matching scores. Finally, the clinical data of two matched groups were compared and

4.
Article in Chinese | WPRIM | ID: wpr-871652

ABSTRACT

Objective:To explore the early surgical outcomes of Thoracoscopic Transmitral Myectomy(TTM) on patients with hypertrophic obstructive cardiomyopathy(HOCM).Methods:Preoperative echocardiography and cardiac magnetic resonance were used to evaluate the patient's hypertrophy extent, mitral valve morphology and function. Myocardial resection was performed via the trans-mitral approach under total thoracoscopy, and the surgical methods and early results were analyzed.Results:From April 2019 to October 2019, a total of 15 cases of TTM were performed by a single surgeon in our ward. Preoperative imaging evaluation revealed that 6 patients(40.0%) had predominantly hypertrophic basal septum while another 9 patients(60.0%) had concomitant midventricular septal hypertrophy. Two(13.3%) patients were interrogated ruptured posterior mitral chord by preoperative echocardiogram. After myocardial resection, the mitral valve was treated as follows: 11 patients(73.3%) underwent anterior leaflet enlargement, and 3(20.0%) were directly reattached to mitral valve annulus, and 1(6.7%) underwent bioprosthetic mitral replacement. There was no case of perioperative death, ventricular septal perforation, residual left ventricular outflow tract obstruction and complete atrioventricular block. Median aortic crossclamp time, cardiopulmonary bypass time, postoperative ventilator use time, ICU stay time, and postoperative hospital stay were 129.0min(116.0, 147.0), 184.0 min(158.0, 227.0), 22.0 h(9.0, 26.0), 3 days(2, 7) and 9 days(7, 14) respectively. No patient lost to follow up, the median follow-up time was 4 months(2, 5). One patient(6.7%) underwent mitral angioplasty three months after surgery due to a tear in the A3 area; the ventricular septal thickness and left ventricular outflow tract pressure decreased significantly(preoperative vs follow-up), and were(19.3±3.3)mm vs. (8.9±4.4) mm( P=0.001), (90.8±23.2)mmHg vs. (8.9±4.4) mmHg(1 mmHg = 0.133kPa)( P<0.001) respectively; no residual SAM was observed during follow-up. Patients with moderate-to severe mitral regurgitation were decreased from 12(80.0%) before surgery to 1(6.7%) during follow up( P<0.001). Conclusion:TTM is a safe and effective procedure for HOCM patients with appropriate surgical indications, providing better exposure to septum from basal to apical area, eliminating left ventricular outflow tract obstruction and SAM-related mitral regurgitation. The anterior mitral valve leaflet should be carefully treated during surgery to reduce the occurrence of residual mitral regurgitation resulted in inappropriate selection of patch size and suturing technique.

5.
Chinese Journal of Geriatrics ; (12): 910-913, 2020.
Article in Chinese | WPRIM | ID: wpr-869485

ABSTRACT

Objective:To analyze the causes of puncture wound infections induced by the high pressure resistant injectable PICC catheter in patients undergoing hematopoietic stem cell transplantation and management measures.Methods:linical data of 75 patients undergoing hematopoietic stem cell transplantation who were treated with the high pressure resistant injectable PICC catheter in our hospital from Nov.2017 to Nov.2019 were retrospectively analyzed.According to whether there were puncture wound infections, patients were divided into the infection group(n=26)and the non-infection group(n=49). Bacterial culture results of the infection group were recorded, and the related factors for puncture wound infections caused by the injectable PICC catheter were analyzed.Effective strategies to prevent high-risk factors, treatment frequency, treatment effect and healing time for patients with different degrees of puncture wound infections were discussed.Results:There were 26 patients in the infection group.The proportions of bacteria types associated with PICC catheter-related infections, in descending order, were as follows: Staphylococcus aureus(46.51%), Klebsiella pneumoniae(30.77%), Corynebacterium(15.38%)and others(7.69%). Significant differences were found in materials used, season of tube placement, timing of dressing changes, duration of catheterization, success rate of first tube placement and condition of dressing films between the non-infection and infection groups( t=5.5, 4.9, 5.0, 13.6, 9.4 and 6.2, all P<0.05). Logistic multi-factor analysis showed that non-U-shaped fixation, delay in dressing changes, long duration of tube placement, low success rate of first tube placement, and loose dressing films were the high-risk factors for PICC catheter-related infections( OR=2.78, 2.42, 3.16, 2.66 and 2.32, all P<0.05). Compared with patients with moderate and mild infections, patients with severe infections had a higher frequency of treatment, a lower total effectiveness rate and a longer healing time( F=10.353, 8.775 and 12.341, all P<0.05). Conclusions:Materials, timing of dressing changes, catheterization time, success rate of first tube placement and condition of dressing films are the high-risk factors for puncture wound infections caused by high pressure resistant injectable PICC catheters in patients undergoing hematopoietic stem cell transplantation.Developing effective intervention strategies can help control the incidence of wound infections.

6.
Article in Chinese | WPRIM | ID: wpr-791100

ABSTRACT

Objective To explore the mediating effect of the childbirth self-efficacy between mind-fulness level and fear of childbirth in pregnant women. Methods A total of 285 pregnant women were measured with five facet mindfulness questionnaire(FFMQ),childbirth attitude questionnaire(FOC),and the short form of the Chinese childbirth self-efficacy inventory(CBSEI-C32). Results The scores of mindful-ness level, fear of childbirth, outcome expectancy and self-efficacy expectancy were ( 127. 51 ± 11. 12), (31. 44±8. 84),(109. 36±30. 52) and(110. 02±30. 03),respectively. Pearson correlation analysis showed that mindfulness level was positively correlated with outcome expectancy and self-efficacy expectancy ( r=0. 247,r=0. 235,both P<0. 01),while negatively correlated with fear of childbirth(r=-0. 274,P<0. 01). Outcome expectancy and self-efficacy expectancy were negatively correlated with fear of childbirth ( r=-0. 251,r=-0. 233,both P<0. 01). The mediating effect of outcome expectancy and self-efficacy expectancy between mindfulness level and fear of childbirth was significant(P<0. 01),and the mediating effect sizes were 17. 8% and 15. 6%, respectively. Conclusion Childbirth self-efficacy partly mediates mindfulness level and fear of childbirth in pregnant women.

7.
Article in Chinese | WPRIM | ID: wpr-800643

ABSTRACT

Objective@#To investigate the effectiveness and safety of Huatan-Quzhuo decoction in combination with western medicine for the treatment of carotid atherosclerotic plaques.@*Methods@#A total of 194 patients with carotid atherosclerosis were selected were randomly divided into two groups, 97 in each group. The control group was treated with simvastatin. The observation group was treated with Huatan-Quzhuo decoction on the basis of the control group. The serum levels of interleukin-1 (IL-1), tumor necrosis factor α (TNF-α), malondialdehyde (MDA), and superoxide dismutase (SOD) were observed before and after treatment in the two groups. The Sod, IMT, number of plaques, number of vulnerable plaques and area of plaques, carotid artery intima-media thickness (IMT), number of plaques, number of vulnerable plaques, and area of plaques were detected.@*Results@#After treatment, the levels of TC, TG, and LDL-C in the observation group were significantly lower than those in the control group (t were 4.546, 6.712, 4.872, P<0.01). After treatment, the IMT (0.85 ± 0.11 mm vs. 1.08 ± 0.13 mm, t=13.302), number of plaques (0.74 ± 0.36 vs. 1.02 ± 0.42, t=4.985), number of vulnerable plaques (0.24 ± 0.25 vs. 0.41 ± 0.27, t=4.550), and plaque area (50.06 ± 9.73 mm2 vs. 68.52 ± 11.24 mm2, t=12.230) in the observation group were significantly lower than those in the control group (P<0.01). The levels of IL-1, TNF-α and MDA in the observation group were significantly lower than the control group (t were 13.089, 4.769, 10.442, P<0.01). The level of SOD was observation group was significantly higher than the control group (t=11.636, P<0.01).@*Conclusions@#The combination of Huatan-Quzhuo decoction and western medicine in the treatment of carotid artery atherosclerosis can regulate the level of blood lipids, improve the degree of atherosclerosis, reduce the degree of inflammation and oxidative stress.

8.
Article in Chinese | WPRIM | ID: wpr-797991

ABSTRACT

Objective@#To explore the mediating effect of the childbirth self-efficacy between mindfulness level and fear of childbirth in pregnant women.@*Methods@#A total of 285 pregnant women were measured with five facet mindfulness questionnaire(FFMQ), childbirth attitude questionnaire(FOC), and the short form of the Chinese childbirth self-efficacy inventory(CBSEI-C32).@*Results@#The scores of mindfulness level, fear of childbirth, outcome expectancy and self-efficacy expectancy were(127.51±11.12), (31.44±8.84), (109.36±30.52)and(110.02±30.03), respectively.Pearson correlation analysis showed that mindfulness level was positively correlated with outcome expectancy and self-efficacy expectancy(r=0.247, r=0.235, both P<0.01), while negatively correlated with fear of childbirth(r=-0.274, P<0.01). Outcome expectancy and self-efficacy expectancy were negatively correlated with fear of childbirth(r=-0.251, r=-0.233, both P<0.01). The mediating effect of outcome expectancy and self-efficacy expectancy between mindfulness level and fear of childbirth was significant(P<0.01), and the mediating effect sizes were 17.8% and 15.6%, respectively.@*Conclusion@#Childbirth self-efficacy partly mediates mindfulness level and fear of childbirth in pregnant women.

9.
Article in Chinese | WPRIM | ID: wpr-823589

ABSTRACT

Objective To investigate the effectiveness and safety of Huatan-Quzhuo decoction in combination with western medicine for the treatment of carotid atherosclerotic plaques. Methods A total of 194 patients with carotid atherosclerosis were selected were randomly divided into two groups, 97 in each group. The control group was treated with simvastatin. The observation group was treated with Huatan-Quzhuo decoction on the basis of the control group. The serum levels of interleukin-1 (IL-1), tumor necrosis factor α (TNF-α), malondialdehyde (MDA), and superoxide dismutase (SOD) were observed before and after treatment in the two groups. The Sod, IMT, number of plaques, number of vulnerable plaques and area of plaques, carotid artery intima-media thickness (IMT), number of plaques, number of vulnerable plaques, and area of plaques were detected. Results After treatment, the levels of TC, TG, and LDL-C in the observation group were significantly lower than those in the control group (t were 4.546, 6.712, 4.872, P<0.01). After treatment, the IMT (0.85 ± 0.11 mm vs. 1.08 ± 0.13 mm, t=13.302), number of plaques (0.74 ± 0.36 vs. 1.02 ± 0.42, t=4.985), number of vulnerable plaques (0.24 ± 0.25 vs. 0.41 ± 0.27, t=4.550), and plaque area (50.06 ± 9.73 mm2 vs. 68.52 ± 11.24 mm2, t=12.230) in the observation group were significantly lower than those in the control group (P<0.01). The levels of IL-1, TNF-α and MDA in the observation group were significantly lower than the control group (t were 13.089, 4.769, 10.442, P<0.01). The level of SOD was observation group was significantly higher than the control group ( t=11.636, P<0.01). Conclusions The combination of Huatan-Quzhuo decoction and western medicine in the treatment of carotid artery atherosclerosis can regulate the level of blood lipids, improve the degree of atherosclerosis, reduce the degree of inflammation and oxidative stress.

10.
Article in Chinese | WPRIM | ID: wpr-745477

ABSTRACT

Objective To analyze the relationship between onset of myocardial infarction(MI)to bivalent antibiotics therapy and outcome in elderly female MI patients.Methods One hundred and fourteen elderly MI patients admitted to our hospital from January 2016to January 2018were divided intoΔT≤188min group(n=57)andΔT>188min group(n=57)according to the onset of MI to bivalent antibiotics therapy.The major adverse cardiac events(MACE),arrhythmia,angina pectoris,heart failure and death were compared between the two groups.Results MACE occurred in 44out of the 144MI patients included in this study.Of the 44MI patients,17died,6 were diagnosed with arrhythmia,16were diagnosed with angina pectoris,5were diagnosed with heart failure.The incidence of arrhythmia,heart failure and the mortality were significantly higher while the incidence of angina pectoris was significantly lower inΔT≤188min group than inΔT> 188min group(7.0%vs 3.5%,7.0%vs 1.8%,15.8%vs 14.0%,7.0%vs 21.1%,P<0.05).Age,diabetes,ΔT,hyperlipidemia,hypertension and coronary artery disease were the independent influencing factors for the poor outcome in MI patients(P<0.05,P<0.01).Conclusion TheΔT should be shortened,the MI patients should be timely treated,the criminal blood vessels should be opened,and the ischemic myocardium should be saved in order to prevent the occurrence of severe cardiovascular events and reduce the mortality in elderly MI patients.

11.
Article in Chinese | WPRIM | ID: wpr-744597

ABSTRACT

Objective To investigate the susceptibility and resistance profile of clinical isolates in Hunan Yongzhou Hospital during 2016 and 2017. Methods Antimicrobial susceptibility testing was carried out according to a unified protocol using KirbyBauer method or automated systems. Results were analyzed according to CLSI 2016 breakpoints. Results A total of 6 354 clinical isolates were collected from January 2016 to December 2017, of which 4 876(76.7%)were gram-negative bacteria, and 1 478(23.3%)were gram-positive bacteria. The top five bacterial species were Escherichia coli(33.0%), Klebsiella(17.0%), Staphylococcus aureus(9.6%), Acinetobacter(8.6%), and Pseudomonas aeruginosa(7.4%). The prevalence of methicillin-resistant Staphylococcus aureus(MRSA)was 33.8%, and prevalence of methicillin-resistant coagulase negative Staphylococcus(MRCNS)was 76.2%. The resistance rates of methicillin resistant strains(MRSA and MRCNS)to most of the tested drugs were significantly higher than those of methicillin sensitive strains(MSSA and MSCNS). No vancomycin or linezolid resistant staphylococci were identified. The resistance rate of Enterococcus faecium to most antimicrobial agents was significantly lower than that of Enterococcus faecium. No enterococcal isolate was resistant to vancomycin or linezolid. The non-meningitis S. pneumoniae strains isolated from children showed slightly higher resistance rate to penicillin(20.8%)than the strains isolated from adults(13.3%). The prevalence of extended spectrum beta-lactamases(ESBLs)in Escherichia coli and Klebsiella pneumoniae was 48.0% and 35.7%, respectively. Most Enterobacteriaceae strains were highly sensitive to carbapenem antibiotics, showing lower resistancerate(<4%). The prevalence of carbapenem-resistant Klebsiella pneumoniae was 18.8%, and the prevalence of carbapenem-resistant E. cloacae was 14.5%. The prevalence of Acinetobacter baumannii strain resistant to imipenem and meropenem was 76.4% and 78.6%, respectively. Conclusions Bacterial resistance is still serious. It is necessary to strengthen the monitoring of bacterial resistance, infection control, and rational use of antibiotics.

12.
Journal of Practical Radiology ; (12): 362-366, 2019.
Article in Chinese | WPRIM | ID: wpr-743537

ABSTRACT

Objective ToinvestigatethevalueofDCEGMRIimagingindifferentiatingmalignanttransformationinvertedpapilloma (IP)frombenignIP.Methods 24casesofIPconfirmedbyoperationandpathologywerecollectedfromJanuary2012toJanuary 2018,including14caseswithbenignIPand10patientswithIP malignanttransformation.Thedynamicenhancementparametersof thetwogroups,theproductoftransferconstant(Ktrans),therefluxrateconstant(Kep),theextravascularextracellularspacevolume fraction (Ve)andthedifferenceoftheareaundertheinitialcurve(iAUC)wereanalyzed.Thesensitivityandspecificityofdifferent parametersintheidentificationofbenignIPandIP malignancytransformationwereevaluated.Results Thereweredifferencesno significantdifferenceinageandsexbetweenbenignIPgroupandIPmalignanttransformationgroup.Therewasasignificantdifference abouttheconvolutedcerebriformpatternbetweenthetwogroups(P=0.004).Therewasnosignificantdifferenceofstagingbetween thetwogroups(P=0.136).TheKtransvaluesofbenignIPgroupandIPmalignanttransformationgroupwere0.21±0.53 (min-1), 0.36±0.93 (min-1),andtherewasasignificantdifferencebetweenthetwogroups(P=0.000).TheiAUCvaluesofbenignIPgroupand IP malignanttransformationgroupwere29.05±5.45,41.14±9.47,respectively,andthedifferenceofiAUCbetweentwogroupswas statisticallysignificant(P=0.001).TherewasnosignificantdifferenceinKepandVebetweenbenignIPfromIPmalignanttransformation (P>0.05).Conclusion BenignIPhasatypicalconvolutedcerebriG formpatternandtheabsenceofitindicatesmalignanttransformation. Thestagingoflesioncan’tdifferentiatethebenignIPfromIP malignanttransformation.DCEGMRIexaminationisworthyinthe evaluationbenignIPandIP malignanttransformation,especiallyKtransandiAUCvalues.

13.
Chinese Journal of Geriatrics ; (12): 851-854, 2018.
Article in Chinese | WPRIM | ID: wpr-709370

ABSTRACT

Objective To explore the clinical characteristics of cognitive impairment in different age groups with the same severity of white matter lesions.Methods This study involved 110 consecutively recruited patients with white matter lesions(WMLs)from the Department of Neurology at Beijing Tiantan Hospital from August 2014 to March 2017.Patients were aged from 50 to 85 with a mean age of 63.1±9.7,and they were divided into an elderly group with a mean age of 71.6±5.2 (range:65-85 years)and a middle aged group with a mean age of 54.8 ± 3.4 (range:50-60 years).The severity of white matter lesions was evaluated with the Fazekas scale.MoCA was used to evaluate the cognitive function of patients.Results For Fazekas 1,the MoCA score was 25.5 ± 2.2 in the elderly group and 28.1 ± 1.4 in the middle aged group(t =6.946,P =0.000);the score for visuospatial and execution abilities was 3.8 ± 0.9 in the elderly group and 4.5 ± 0.6 in the middle aged group(t =3.7 2 6,P =0.0 2 3);the score for delayed memory was 2.7 ± 1.5 in the elderly group and 4.0 ± 1.0 in the middle aged group(t =4.365,P =0.018).For Fazekas 2,the MoCA score was 22.5±2.5 in the elderly group and 24.1 ± 1.5 in the middle aged group(t =3.361,P =0.034);the score for visuospatial and execution abilities was 2.8 ± 1.2 in the elderly group and 3.8 ± 0.8 in the middle aged group(t=6.473,P=0.007);the score for concentration was 4.6± 1.3 in the elderly group and 5.6±0.5 in the middle aged group(t=0.491,P=0.721).For Fazekas 3:the MoCA score was 15.2 ± 3.4 in the elderly group and 19.4 ± 2.8 in the middle aged group(t =4.709,P =0.001);the score for visuospatial and execution abilities was 1.8 ± 1.1 in the elderly group and 2.8± 1.4 in the middle aged group(t =1.563,P =0.043);the score for concentration was 3.3± 1.1 in the elderly group and 4.4± 1.4 in the middle aged group(t=2.231,P=0.026);the score for orientation was 4.2 ± 1.3 in the elderly group and 5.7 ± 0.5 in the middle aged group (t=3.255,P =0.000).Conclusions WMLs can increase the risk of vascular cognitive impairment and cause decline in multiple cognitive functions in both middle aged and elderly people.Cognitive dysfunction in age-related WMLs is mainly characterized by impairment in visuospatial and execution abilities.

14.
Article in Chinese | WPRIM | ID: wpr-707769

ABSTRACT

Objective To compare the difference in risks of obstetric complications of singleton pregnancy between women with hyperandrogenic polycystic ovary syndrome (PCOS) and women with normoandrogenic PCOS. Methods Prospective cohort study. This study was a secondary analysis of data collected during a multicenter randomized controlled clinical trial. Women who got clinical singleton pregnancy were grouped according to whether they were diagnosed with hyperandrogenism at baseline. There were 118 women with hyperandrogenism and 366 women without hyperandrogenism. The incidences of obstetric complications and birth weight were compared between the two groups. Results Women with hyperandrogenic PCOS had a significantly higher risk of preterm delivery than women with normoandrogenic PCOS [12.7% (15/118) versus 3.6% (13/366); OR=3.94, 95%CI: 1.82-8.56]. After adjustment of age, duration of infertility, body mass index, and fresh or frozen embryo transfer group, hyperandrogenism was still associated with an increased risk of preterm delivery (OR=3.67, 95%CI: 1.67-8.07). Compared with women with normoandrogenic PCOS, women with hyperandrogenic PCOS had similar risks of pregnancy loss, gestational diabetes mellitus, pre-eclampsia, placenta previa, and postpartum hemorrhage (all P>0.05). Birth weight as well as the risks of being small for gestational age and large for gestational age were also comparable between the two groups (all P>0.05). Conclusion In women with PCOS and singleton pregnancy, those with preconceptional hyperandrogenism have a higher risk of preterm delivery than those without hyperandrogenism.

15.
Cancer Research and Clinic ; (6): 365-369, 2018.
Article in Chinese | WPRIM | ID: wpr-712830

ABSTRACT

Objective To investigate the effects of cerium oxide nanoparticles of different sizes on the number and constructions of immune cells in peripheral blood of mice after X-ray irradiation. Methods Mice were randomly divided into 4 groups according to body weight layer and the weight of each mouse was weighed. All mice were divided into 6 groups according to weight from high to low, and there were 4 mice in each group. Then 1 mouse was randomly taken from each group to form the control group. Model group, 5 nm and 25 nm cerium oxide nanoparticles groups were formed in turn. There were 6 mice in each group. The mice in model group and cerium oxide nanoparticles administration groups were irradiated once with 3 Gy of X-rays. The mice in cerium oxide nanoparticles groups began to be intraperitoneally administrated once a day with 10 μg 5 nm or 25 nm cerium oxide nanoparticles per kilogram body weight on the 4th day before irradiation and once every other 2 days after irradiation. The mice in the control group and model group were intraperitoneally administrated with 0.9 % saline. The mice were killed on the 10th days after irradiation. White cells count (WBC) and classification in peripheral blood were detected by using automatic globulimeter, and lymphocyte subsets were analyzed by using flow cytometry. Results Compared with the control group, the number of WBC, neutrophil granulocytes, monocytes, lymphocytes, total T lymphocytes, CD4+and CD8+T lymphocytes and the percentages in the model group were decreased (all P<0.05), and percentages of the lymphocytes, B cells and NK cells and ratio of CD4 to CD8 were increased in model group (all P< 0.05). Compared with the model group, the above parameters except percentages of T lymphocytes, CD4+and CD8+T lymphocytes were improved in mice of 5 nm cerium oxide nanoparticle group (all P <0.05). Compared with the control group, the number of WBC and lymphocytes were decreased in the 5 nm cerium oxide nanoparticle group (P<0.05), and there were no significances in other parameters compared with the control group (all P >0.05). Compared with the control group, the number of WBC and lymphocytes, the number and percentages of T lymphocytes, CD4+and CD8+T lymphocytes and the percentages were decreased (all P< 0.05), and percentage of NK cells and ratio of CD4 to CD8 were significantly increased in 25 nm cerium oxide nanoparticles group (all P< 0.05). The number of lymphocytes and CD8+T lymphocytes in 25 nm cerium oxide nanoparticles group was lower than that in 5 nm cerium oxide nanoparticles group (all P < 0.05). Conclusions The effects of cerium oxide nanoparticles of different sizes on the immune cells of mice after X-ray irradiation are different, and 5 nm cerium oxide nanoparticle is superior to 25 nm cerium oxide nanoparticle.

16.
Article in Chinese | WPRIM | ID: wpr-712483

ABSTRACT

To implement the task of health anti-poverty campaign,the medical alliance of northwest Guangxi hospitals made full use of its synergy strengths to achieve remarkable progress in constructing a telemedicine cooperation network, nurturing medical discipline of primary hospitals in the alliance, promoting regional medical resources sharing, and improving the humanities connection mechanism.To further develop health anti-poverty via medical alliances,relevant institutions are recommended to probe into such problems as telemedicine compensation mechanism,precision-based disciplinary support,breakdown of resource sharing barriers and profit distribution mechanisms.

17.
Clinical Medicine of China ; (12): 362-365, 2018.
Article in Chinese | WPRIM | ID: wpr-706686

ABSTRACT

Objective To investigate the correlation between serum lectin like oxidized low density lipoprotein receptor-1 ( sLOX-1 ) and left ventricular diastolic function in patients with essential hypertension. Methods From January 2016 to July 2017, one hundred and forty-six patients with essential hypertension were selected and divided into two groups according to the ratio of E/ A,the left ventricular diastolic function group (76 cases) and the left ventricular diastolic function group (70 cases),the sLOX-1 level of the patients was detected by ELISA method, and the left ventricular diastolic function was evaluated by echocardiography. The correlation between sLOX-1 and left ventricular diastolic function was analyzed. Results The serum sLOX-1 levels in left ventricular diastolic function group (( 208. 12 ± 13. 48 ) μg/ L ) were significantly higher than those inthe left ventricular diastolic function group ((152. 12 ± 12. 96) μg/ L) . The difference between the two groups was statistically significant (t= 6. 586,P= 0. 000). Logistic regression analysis showed that serum sLOX-1 was a influence factor of left ventricular diastolic function (OR= 2. 42,95%CI 1. 42-2. 82,P = 0. 036) . Conclusion The levels of serum sLOX-1 can be used as a indicator of left ventricular diastolic function.

18.
Journal of Practical Radiology ; (12): 611-613,628, 2017.
Article in Chinese | WPRIM | ID: wpr-609083

ABSTRACT

Objective To study the effect of the combination of pathidine hydrochloride and anisodamine on the intraoperative effiacy of transhepatic biliary drainage and stent implantation done on the patient with advanced malignant obstructive jaundice.Methods 100 cases of percutaneous transhepatic catheterizde drainage (PTCD) and percutaneous transhepatic biliary stenting (PTBS) done for advanced malignant obstructive jaundice were divided into control group and experimental group,50 cases in each group.In experimental group,100 mg pethidine hydrochloride and 10 mg anisodamine were injected intramuscularly 30 min before operation,while in control group,no analgesic or antispasmodic were used before and during operation.The blood pressure and heart rate were observed,the incidence rate of biliary-cardiac reflex and operating time were recorded,while the scale of pain felt by patient was evaluated with visual analogue scale.Results Compared to the control group,the patients in experimental group have more stable vital signs,feel more comfortable,suffering shorter operative time,less incidence rate of biliary cardiac reflex and less pain by using pethidine hydrochloride and anisodamine.Conclusion Application of pathidine hydrochloride and anisodamine during the transhepatic biliary drainage and stent implantation done on the patient with advanced malignant obstructive jaundice may release pain,reduce operating time.It is safe,at lower cost and can be used as routine medicine before PTCD or PTBS.

19.
Tianjin Medical Journal ; (12): 372-376, 2017.
Article in Chinese | WPRIM | ID: wpr-514824

ABSTRACT

Objective To investigate the effect of brain natriuretic peptide (BNP) on serum angiotensin-converting enzyme (ACE) 2 levels in acute heart failure patients with reduced ejection fraction (HFrEF). Methods A total of 106 patients with acute HFrEF were selected, and were divided randomly into control group and trial group. The control group was under routine treatment, while the trial group was under routine treatment combined with lyophiluzed recombinant human BNP for 24-hour. Cardiac functional parameters were measured by echocardiography both at the enrollment and the end of 7-day treatment. Serum levels of ACE2 and N-terminal pro-BNP (NT-proBNP) were determined using commercially available ELISA kits at the enrollment, the end of 24-hour treatment, and the end of 7-day treatment,respectively. Results A total of 103 patients with acute HFrEF were enrolled (control group=51, trial group=52). There were no significant differences in the use of drugs (e.g., aspirin) and serum biochemical indices (e.g. cardiac troponin I, creatinine) before treatment between these two groups. Compared to systolic blood pressure (SBP) at admission, SBP on the second day after treatment were significantly decreased in two groups (P0.05);there were also no significant differences in DBP on the second day after treatment, and LVEF on the seventh day after treatment (P>0.05), while SBP was significantly higher on the second day after treatment in control group than that of trial group (P < 0.05). Serum levels of NT-proBNP were decreased with the prolongation of time in two groups. Serum levels of ACE2 were decreased with the prolongation of time in control group, while were increased initially following decreased (which were still higher on the seventh day after treatment than that at admission) with the prolongation of time in trial group. Serum levels of NT-proBNP were higher after 2 days treatment or 7 days of treatment in control group than those of trial group, while serum levels of ACE2 were decreased after 2 days of treatment or 7 days of treatment in control group than those of trial group (P<0.05). Conclusion Patients with acute HFrEF may benefit from BNP by increasing serum ACE2 levels.

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Article in Chinese | WPRIM | ID: wpr-513634

ABSTRACT

Inhibin B(INHB) and anti-Müllerian hormone(AMH) detection have important clinical significance in assisted reproductive technology.INHB for evaluation of male testis function is very meaningful,playing a guiding role in the treatment of oligospermatism.INHB has very high clinical diagnosis value for evaluation of ovarian reserve function,being an important indicator to predict the effect of controlled ovarian hyperstimulation.AMH for evaluation of women ovarian function is significant,and is a diagnosis index of reproductive domain related diseases such as polycystic ovary syndrome and one of the important indices for evaluation of assisted reproductive outcomes.

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