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1.
Article in Chinese | WPRIM | ID: wpr-904497

ABSTRACT

objective:To analyze the contributed papers and publications in the first half year of 2020 from Shanghai Journal of Preventive Medicine, especially the COVID-19 papers, to provide basis for the academic journals to win out during the public hot points. Methods:All the papers contributed in the first half year of 2020 from Shanghai Journal of Preventive Medicine, were collected to analyze the sources parameters, editing parameters. All published papers were collected to analyze the sources parameters, editing parameters and their usages (downloads and citations). Results:There were 450 papers contributed in the first half year of 2020, 129 papers were accepted accounting for 28.67%. Among them, 116 papers were COVID-19 papers accounting for 25.78%, and 32 papers were accepted accounting for 24.81%. the March was the highest month of contribution, also for COVID-19 papers. Many academic domains such as infectious disease, women and children health, clinic science, chronic disease, social medicine, public hygiene and others were predominated among those papers. COVID-19 papers dominated in domains of infectious disease and social medicine. According to the non-COVID-19 papers, the COVID-19 papers had higher numbers of peer reviewers, lower days for back improvement, lower days for refusals or acceptance, also had lower copy percentages by plagiarism check (all P<0.05). there were 106 papers published in the first half year of 2020. Published COVID-19 papers had higher number of authors, higher numbers of references in term of governments reports, foreign references and less than 5 years references (all P<0.05). Those published COVID-19 papers had better usages than those no-COVID-19 papers, adjusted downloads were 2 077.37/year vs 111.53/year, adjusted citations were 12.99/year vs 0.49/year. It was obvious that the published COVID-19 papers had very excellent social influences and academic influences (P<0.001). Conclusion:Publication in the first half year of 2020 from Shanghai Journal of Preventive Medicine is high-qualified and is good for the journal’s improvement in social influences and academic influences. It is important for academic journals to pay more attention to the hot points of public health accordingly.

2.
Chinese Journal of Urology ; (12): 925-931, 2021.
Article in Chinese | WPRIM | ID: wpr-911151

ABSTRACT

Objective:To comprehensively analyze the expression profile of circular RNA (circRNA) and construct competing endogenous RNA (ceRNA) regulatory networks in tuberous sclerosis complex related renal angiomyolipoma (TSC-RAML).Methods:According to the diagnostic criteria of TSC determined by the international consensus group on tuberous sclerosis in 2012, tumor tissues and paired normal renal tissues of 3 patients with TSC-RAML who were diagnosed in our hospital from January 2017 to January 2019 were collected. The circRNA, miRNA and mRNA of 3 paired samples were detected by circRNA, miRNA chip technology and next generation sequencing respectively, and the differential molecules were determined. Gene Ontology(GO) functional enrichment analysis and Kyoto Encyclopedia of genes and genomes(KEGG) pathway enrichment analysis were performed based on differential mRNA molecules and host genes of circRNA. Based on differential circRNA, miRNA and mRNA, up-regulated and down-regulated ceRNA regulatory networks were established.Results:A total of 330 up-regulated and 336 down-regulated differential circRNA, 8 up-regulated and 7 down-regulated miRNA, 800 up-regulated and 1130 down-regulated mRNA were screened. Through GO and KEGG enrichment analysis, many pathways including lipid metabolism, focal adhesion and mineral absorption were abnormally altered. Finally, the up-regualted ceRNA network led by hsa_circ_0092022, hsa_circ_0076859 and hsa_circ_0033388 and down-regulated network led by hsa_circ_0000374, hsa_circ_0000141, hsa_circ_0072665, hsa_circ_0009503 and hsa_circ_0000009 were constructed.Conclusions:There were many differentially expressed circRNA between TSC-RAML and paired normal renal tissues. ceRNA regulatory networks may be involved in the occurrence and development of TSC-RAML.

3.
Article in Chinese | WPRIM | ID: wpr-888128

ABSTRACT

The tumor prescriptions contained in Dictionary of Tumor Formulas, Compendium of Good Tumor Formulas, Chinese Pharmacopoeia, Ministry of Health Drug Standards for Chinese Medicine Formulas and National Compilation of Standards for Proprietary Chinese Medicines were selected and organized to construct a database for tumor prescriptions, and the data mining techniques were applied to investigate the prescription regularity of colorectal cancer prescriptions. The formula data were extracted after screening in strict accordance with the inclusion and exclusion criteria, and were then analyzed with Microsoft Excel 2010 for frequency statistics, Apriori block provided by SPSS Clementine 12.0 software for correlation rule analysis, and arules and arulesViz packages in R 4.0.2 software for correlation rule visualization. In addition, SPSS 18.0 software was used for cluster analysis and factor analysis, in which cluster analysis was performed by Ochiai algorithm with bicategorical variables in systematic clustering method and factor analysis was performed mainly with principal component analysis. A total of 285 prescriptions were included in the statistical analysis, and the frequency statistics showed that 43 herbs had been used more than 16 times. The association rules analysis showed that 26 high-frequency me-dicine pair rules were obtained, and the association rules for those dispelling evil spirits, strengthening the body, resolving stasis, dispelling dampness, etc. were visualized. In the cluster analysis, we generated a dendrogram from which 7 groups of traditional Chinese medicines with homogeneity were extracted. 10 common factors were obtained in the factor analysis. The types of herbal medicines involved in the colorectal cancer prescription included anti-cancer antidotes, strengthening and tonifying medicines, blood-regulating medicines, and expectorant medicines, corresponding to the treatment for eliminating evil spirits, strengthening, resolving stasis, and expectorating dampness. The prescriptions for anti-cancer detoxification were normally based on the pairs composed of Scutellaria barbata-Hedyotis diffusa and Sophora flavescens, Sargentodoxa cuneata, S. barbata, often combined with stasis relieving drug and dampness eliminating drug, reflecting the characteristics of treatment for both toxicity and stasis, dampness and toxicity simultaneously. The prescriptions for strengthening the righteousness and tonifying the deficiency were composed of Astragalus membranaceus and Atractylodes macrocephala mainly, exerting the effect of benefiting Qi, strengthening the spleen and drying dampness, tonifying kidney and essence, tonifying blood and invigorating blood. Meanwhile, anti-cancer detoxification medicines shall be reduced as much as possible. The compatibility of the medicines for the intestinal tract reflected the principle of using the right medicine for the right condition and eliminating evil spirits or strengthening the body, as appropriate.


Subject(s)
Colorectal Neoplasms/drug therapy , Data Mining , Drug Prescriptions , Drugs, Chinese Herbal/therapeutic use , Humans , Medicine, Chinese Traditional
4.
Article in Chinese | WPRIM | ID: wpr-884656

ABSTRACT

Objective:To study the value of metastatic positivety in lymph nodes group 8a in deciding on extended lymph node dissection in pancreaticoduodenectomy(PD) for pancreatic head cancer.Methods:A retrospective study on 165 patients with pancreatic head cancer treated with PD at the Department of Pancreas and Spleen Surgery, Hepatobiliary Hospital of Hunan Provincial People's Hospital between January 2014 to June 2019 was performed. There were 101 males and 64 females with ages ranging from 38 to 75 (median 57) years. Patients who underwent standard lymph node dissection were included in the standard group ( n=88), and extended lymph node dissection in the extended group ( n=77). These patients were further divided into 4 subgroup. Subgroup A (standard PD in patients with negative nodes in group 8a, n=61), Subgroup B (extended PD in patients with negative nodes in group 8a, n=47), Subgroup C (standard PD in patients with positive nodes in group 8a, n=27), and Subgroup D (extended PD in patients with positive nodes in group 8a, n=30). The operation time, intraoperative blood loss, postoperative survival rates, complications were compared among the groups and subgroups. Results:The operation time and intraoperative blood loss of the standard group were (456.8±30.4) min and (264.28±101.14) ml, respectively, which were significantly lower than the extended group of (507.1±45.7) min and (388.9±155.3) ml (all P<0.05). The incidence of postoperative complications in the extended group (31.2%, 24/77) was significantly higher than that in the standard group (14.8%, 13/88) ( P<0.05). When compared with subgroup B, the cumulative survival rate of patients in subgroup A was not significantly different ( P>0.05). However, the cumulative survival rate of patients in subgroup C was significantly lower than that in subgroup D ( P<0.05). The cumulative survival rate of subgroup A was also significantly better than that of subgroup C ( P<0.05). There was no significant difference in the cumulative survival rates between group B and group D ( P>0.05). Conclusions:PD with extended lymph node dissection improved the survival rates in patients with cancer of the head of the pancreas with positive lymph nodes in group 8a. For these patients, extended lymph node dissection is recommended. With negative lymph nodes in group 8a, standard lymph node dissection is recommended.

5.
Article in Chinese | WPRIM | ID: wpr-875959

ABSTRACT

Media convergence is the combination and convergence of every element of media in forms of breakdown of traditional classification, formats and distribution etc. It means the blending of its contents, consumers and operations in full and a new media was developed named as new media. The paper tries to explore the media convergence by starting from the paper-printed media, especially from the scientific journals. It is obvious that the basement is the electronization of media, comprehensive use of multi-technology is the fundamental tools, and it made the results of the inevitability of deep changes in term of thoughts, mindset and managerial principles as well. At the same time, the adverse effect of media convergence consequently coming from the freedom and openness of media convergence will be considered and avoided, so the surveillance of administrative functions and technicals should be adopted or developed accordingly.

6.
Article in Chinese | WPRIM | ID: wpr-905419

ABSTRACT

Objective:To observe the effect of early weight-bearing on the appropriate population with intertrochanteric fracture after surgery. Methods:From April, 2017 to December, 2018, a total of 45 patients with Evans-Jensen type II intertrochanteric fracture and fracture reduction as positive medial cortex support (PMCS) after proximal femoral nail anti-rotation (PFNA) fixation were randomly divided into control group (n = 22) and experimental group (n = 23). Weight-bearing as tolerated (WBAT) was initiated from six weeks after surgery in the control group, and within 48 h after surgery in the experimental group. The frequency of WBAT in two groups increased gradually from three times a day for ten minutes a time to five times a day for 20 minutes a time until clinical healing of fracture. The length of stay, hospital cost, the fracture healing time and the complication incidence were compared between two groups, as well as the scores of Visual Analogue Scale (VAS) and Harris Hip Score at six weeks, three months and six months after surgery. Results:Compared with the control group, the length of stay was shorter (t = 3.716, P < 0.01), the hospital cost was lower, but no significant difference was found (t = 1.540, P > 0.05), and the fracture healing time was shorter (t = 6.248, P < 0.001) in the experimental group. The complication incidence was lower in the experimental group, but there was no significant difference (χ2= 2.198, P > 0.05). Six weeks, three months and six months after surgery, there was no significant difference in the score of VAS between two groups (t < 1.330, P > 0.05). The score of Harris Hip Score was significantly higher in the experimental group than in the control group six weeks after surgery (t = -5.115, P < 0.001), however, no significant difference was found in other time points (|t| < 1.799, P > 0.05). Conclusion:Early weight-bearing within 48 h after PFNA fixation for Evans-Jensen type II intertrochanteric fractures and reduction with PMCS could shorten the length of stay, shorten the bony healing time and promote early recovery of hip function.

7.
Article in Chinese | WPRIM | ID: wpr-865070

ABSTRACT

Objective:To investigate the classification and surgical management of chronic calcifying pancreatitis.Methods:The retrospective and descriptive study was conducted. The clinical data of 121 patients with chronic calcifying pancreatitis who were admitted to Hunan Provincial People′s Hospital from January 2015 to December 2019 were collected. There were 99 males and 22 females, aged from 10 to 78 years, with a median age of 43 years. The patients with type Ⅰ chronic calcifying pancreatitis underwent pancreaticoduodenectomy, duodenum-preserving pancreatic head total resection, or duodenum-preserving pancreatic head spoon-type resection respectively, and external drainage when combined with peripancreatic pseudocyst. Patients with type Ⅱ chronic calcifying pancreatitis underwent resection of pancreatic body and tail combined with splenectomy or dissection of pancreatic duct combined with pancreato-jejunum Roux-en-Y anastomosis. Patients with type Ⅲ chronic calcifying pancreatitis underwent pancreaticoduodenectomy or duodenum-preserving pancreatic head spoon-type resection, and external drainage when combined with peripancreatic pseudocyst. Patients with type Ⅳ chronic calcifying pancreatitis underwent basin-type internal drainage. Observation indicators: (1) surgical situations; (2) postoperative situations; (3) follow-up. Follow-up using outpatient examination and telephone interview was performed to detect the recurrence of pain or chronic pancreatitis, the data of blood glucose, the morbidity of diabetes and diarrhea after surgery up to January 2020. Measurement data with normal distribution were represented as Mean± SD and measurement data with skewed distribution were described as M (range). Count data were represented as absolute numbers. Results:(1) Surgical situations: of the 48 patients with type Ⅰ chronic calcifying pancreatitis, 15 patients underwent pancreaticoduodenectomy with the operation time of (6.8±1.9)hours and volume of intraoperative blood loss of (398±110)mL, 8 patients underwent duodenum-preserving pancreatic head total resection due to no dilation of pancreatic duct with the operation time of (3.7±0.8)hours and volume of intraoperative blood loss of (137±62)mL, 25 patients underwent duodenum-preserving pancreatic head spoon-type resection due to dilation of pancreatic duct with the operation time of (3.9±1.5)hours and volume of intraoperative blood loss of (123±58)mL. Of the 8 patients with type Ⅱchronic calcifying pancreatitis, 2 patients underwent resection of pancreatic body and tail combined with splenectomy with an average operation time of 5.1 hours and an average volume of intraoperative blood loss of 200 mL, 6 patients underwent dissection of pancreatic duct combined with pancreato-jejunum Roux-en-Y anastomosis with the operation time of (2.7±0.8)hours and volume of intraoperative blood loss of (145±39)mL. Of the 49 patients with type Ⅲ chronic calcifying pancreatitis, 4 patients were underwent pancreaticoduodenectomy with the operation time of (7.2±1.4)hours and volume of intraoperative blood loss of (415±98)mL, 45 patients underwent duodenum-preserving pancreatic head spoon-type resection due to dilation of pancreatic duct with the operation time of (4.3±1.1)hours and volume of intraoperative blood loss of (135±47)mL. Sixteen patients with type Ⅳ chronic calcifying pancreatitis underwent basin-type internal drainage with the operation time of (3.3±1.3)hours and volume of intraoperative blood loss of (150±27)mL. (2) Postoperative situations: 15 of the 48 patients with type Ⅰ chronic calcifying pancreatitis who underwent pancreaticoduodenectomy had the time to first anal flatus of (2.9±1.1)days, time to initial fluid diet intake of (3.5±1.1)days, and duration of hospital stay of (14.8±2.7)days, respectively. Of the 3 patients who had postoperative complications, 2 had gastrointestinal hemorrhage (1 case was cured after hemostasis under gastroscope and the other was cured after interventional therapy), 1 with grade A pancreatic fistula was cured after delaying the time of extubation, no biliary fistula occurred. Eight patients undergoing duodenum-preserving pancreatic head total resection had the time to first anal flatus of (2.0±0.5)days, time to initial fluid diet intake of (2.5±0.4)days, and duration of hospital stay of (9.5±2.5)days, respectively. One case with postoperative grade A pancreatic fistula was cured after delaying the time of extubation. Twenty-five patients undergoing duodenum-preserving pancreatic head spoon-type resection had the time to first anal flatus of (2.4±0.8)days, time to initial fluid diet intake of (2.5±1.3)days, and duration of hospital stay of (9.8±3.1)days, respectively. One case with postoperative gastrointestinal hemorrhage was cured after interventional therapy and 1 case with grade A pancreatic fistula was cured after delaying the time of extubation. Two of the 8 patients with type Ⅱ chronic calcifying pancreatitis who underwent resection of pancreatic body and tail combined with splenectomy had an average time to first anal flatus of 3.0 days, an average time to initial fluid diet intake of 3.5 days, and an average duration of hospital stay of 14.0 days, respectively.There was no complication during perioperative period. Six of the 8 patients with type Ⅱ chronic calcifying pancreatitis who underwent dissection of the pancreatic duct combined with pancerato-jejunum Roux-en-Y anastomosis had the time to first anal flatus of (2.5±0.5)days, time to initial fluid diet intake of (2.5±0.7)days, and duration of hospital stay of (8.5±1.5)days, respectively. Two cases with postoperative grade A pancreatic fistula were cured after delaying the time of extubation. Four of the 49 patients with type Ⅲ pancreatic duct stone who underwent pancreaticoduodenectomy had the time to first anal flatus of (3.2±0.8)days, time to initial fluid diet intake of (4.1±1.2)days, and duration of hospital stay of (15.3±2.4)days, respectively. One case with postoperative grade A pancreatic fistula was cured after delaying the time of extubation without hemorrhage or biliary fistula. Forty-five of the 49 patients with type Ⅲ chronic calcifying pancreatitis who underwent duodenum-preserving pancreatic head spoon-type resection had the time to first anal flatus of (2.5±1.6)days, time to initial fluid diet intake of (2.8±0.9)days, and duration of hospital stay of (10.1±2.8)days, respectively. One case with postoperative anastomotic bleeding was cured after reoperation. One case with grade A pancreatic fistula was cured after delaying the time of extubation and 1 case with postoperative grade B pancreatic fistula was cured after puncture-duct-douch treatment. Sixteen patients with type Ⅳ chronic calcifying pancreatitis who underwent basin-type internal drainage had the time to first anal flatus of (2.6±0.7)days, time to initial fluid diet intake of (3.3±0.5)days, and duration of hospital stay of (10.4±3.0)days respectively. One case with intraperitoneal hemorrhage which represented as small amount of dark red liquid in the drainage tube of jejunum loop was cured after puncture-duct-douch treatment with noradrenaline sodium chloride solution. (3) Follow-up: Of the 121 patients, 113 (44 of type Ⅰ, 7 of type Ⅱ, 46 of type Ⅲ, 16 of type Ⅳ) were followed up for 3-58 months, with an average time of 34 months. During the follow-up, 13 patients (5 of type Ⅰ, 1 of type Ⅱ, 6 of type Ⅲ, 1 of type Ⅳ) had the recurrence of pain or pancreatitis, 55 patients (15 of type Ⅰ, 40 of type Ⅲ) with abdominal pain were improved significantly, and 45 patients (24 of type Ⅰ, 6 of type Ⅱ, 15 of type Ⅳ) did not have abdominal pain. Of the 37 patients (13 of type Ⅰ, 2 of type Ⅱ, 17 of type Ⅲ, 5 of type Ⅳ) with diabetes , 20 (6 of type Ⅰ, 2 of type Ⅱ, 12 of type Ⅲ) had blood glucose returned to normal and 17 (7 of type Ⅰ, 5 of type Ⅲ, 5 of type Ⅳ) needed controlling blood sugar with medicine. There were 5 patients (4 of type Ⅰ, 1 of type Ⅲ) diagnosed with diabetes and 3 patients (1 of type Ⅱ, 2 of type Ⅲ) with diarrhea postoperatively. Two patients of type Ⅲ chronic calcifying pancreatitis died, including 1 died of pancreatic cancer at 18 months after pancreaticoduodenectomy and 1 died of severe acute pancreatitis at 5 months after duodenum-preserving pancreatic head spoon-type resection.Conclusions:Chronic calcifying pancreatitis is a benign disease and should be treated to preserve functional tissues. Different surgical procedures should be adopted to treat different types of calcifying pancreatitis.

8.
Article in Chinese | WPRIM | ID: wpr-828301

ABSTRACT

OBJECTIVE@#To study and analyze the clinical effect of the self-developed new adjustable weight-bearing rehabilitation brace in the rehabilitation of the femoral intertrochanteric fracture after the operation of PFNA.@*METHODS@#From July 2015 to June 2017, 62 patients with typeⅡ (Evans-Jensen classification) intertrochanteric fracture of femur were treated with PFNA internal fixation. There were 11 males and 19 females in the routine rehabilitation group, with an average age of (70.73± 6.09) years;17 males and 15 females in the brace rehabilitation group, with an average age of (71.25±6.60) years. Among them, the patients in the routine rehabilitation group recovered according to the routine method, and the patients in the support rehabilitation group used the self-developed new adjustable weight-bearing rehabilitation support of lower limbs to assist the early rehabilitation. The pain intensity(VAS score), weight-bearing of affected limb, clinical healing time of fracture, Harris score and complications were recorded and analyzed.@*RESULTS@#Nine patients lost their visit half a year later, the other 53 patients were followed up for 9 to 18 months. The VAS score at 1, 3, 6 months after operation of brace rehabilitation group was lower than that of routine rehabilitation group(<0.05). The weight bearing of the limbs in the rehabilitation group was significantly higher than that in the conventional rehabilitation group(<0.05), but the clinical healing time of fracture in the brace rehabilitation group was shorter than that in the routine rehabilitation group(<0.05). In addition, the Harris score of the postoperativebrace rehabilitation group was better than that of the conventional rehabilitation group(<0.05). The incidence of complications was lower than that of the conventional rehabilitation group(=0.048).@*CONCLUSION@#In the rehabilitation of Evans Jensen typeⅡintertrochanteric fracture after PFNA internal fixation, the new self-developed adjustable weight-bearing rehabilitation brace can significantly relieve postoperative pain, regulate and moderately increase the stress stimulation at the fracture end, so as to promote fracture healing, accelerate the recovery of hip joint function, reduce the incidence of complications, and its clinical effect is safe and reliable.


Subject(s)
Aged , Bone Nails , Braces , Female , Fracture Fixation, Intramedullary , Hip Fractures , Humans , Lower Extremity , Male , Middle Aged , Retrospective Studies , Treatment Outcome , Weight-Bearing
9.
Article in Chinese | WPRIM | ID: wpr-781761

ABSTRACT

In this paper, the micro-video teaching mode was explored in the course construction of . The micro-video teaching contents include the academic thought, experience in diagnosis and treatment, characteristic technology and clinical manipulation of famous acupuncture experts in the Henan University of CM. Each micro-video film is designed within 15-18 min, including three sections of knowledge, i.e. basic theory, technological application and clinical manipulation. Each section is designed within 5-6 min. The construction of the teaching course of is the innovation of practice mode of TCM and the new approach to the inheritance of the experience of experts. The construction of micro-video teaching course propels the reform of teaching mode, improves the learning initiative of students and clinical manipulative ability so as to improve the teaching effect and quality.


Subject(s)
Acupuncture Therapy , Humans , Learning , Moxibustion , Students , Teaching
10.
Chinese Medical Journal ; (24): 1974-1982, 2019.
Article in English | WPRIM | ID: wpr-802779

ABSTRACT

Objective@#Ultrasound imaging is well known to play an important role in the detection of thyroid disease, but the management of thyroid ultrasound remains inconsistent. Both standardized diagnostic criteria and new ultrasound technologies are essential for improving the accuracy of thyroid ultrasound. This study reviewed the global guidelines of thyroid ultrasound and analyzed their common characteristics for basic clinical screening. Advances in the application of a combination of thyroid ultrasound and artificial intelligence (AI) were also presented.@*Data sources@#An extensive search of the PubMed database was undertaken, focusing on research published after 2001 with keywords including thyroid ultrasound, guideline, AI, segmentation, image classification, and deep learning.@*Study selection@#Several types of articles, including original studies and literature reviews, were identified and reviewed to summarize the importance of standardization and new technology in thyroid ultrasound diagnosis.@*Results@#Ultrasound has become an important diagnostic technique in thyroid nodules. Both standardized diagnostic criteria and new ultrasound technologies are essential for improving the accuracy of thyroid ultrasound. In the standardization, since there are no global consensus exists, common characteristics such as a multi-feature diagnosis, the performance of lymph nodes, explicit indications of fine needle aspiration, and the diagnosis of special populations should be focused on. Besides, evidence suggests that AI technique has a good effect on the unavoidable limitations of traditional ultrasound, and the combination of diagnostic criteria and AI may lead to a great promotion in thyroid diagnosis.@*Conclusion@#Standardization and development of novel techniques are key factors to improving thyroid ultrasound, and both should be considered in normal clinical use.

11.
Article in Chinese | WPRIM | ID: wpr-744551

ABSTRACT

Objective To observed the clinical effect of long-term sacral nerve stimulation on anal rectal pain after lumbar surgery.Methods A total of 18 cases with functional anorectal pain (FARP) after lumbar surgery in our hospital from April 2015 to March 2018were selected, of whom 3 cases refuse to accept the treatment, the other 15 cases received sacral nerve electrical stimulation.The Pittsburgh Sleep Quality Index (PSQI) and simplified MPQ pain questionnaire were used to evaluate the clinical effect in preoperative and postoperative1 week, 1 month, 3 months, 6 months, 9 months and 1 year respectively.Results Fifteen cases of permanent sacral nerve stimulation before and after , The MPQ scale and PSQI of 15 patients with implantation of permanent sacral nerve stimulation in postoperative 1 week were better than those before implantation , the differences were significant( P< 0. 05) . In the MPQ scale , the PPI and PRI at 6 months after operation was better than those before implantation , the difference was statistically significant ( P < O. 01 ) ; PSQI and V AS score after 2 months were better than those before implantation , the difference were statistically significant( P < 0.01) , meanwhile in 1-year of follow-up , the PSQI and VAS score continued to decline , but the change was not obvious. Conclusion Long-term sacral nerve electrical stimulation in the treatment of lumbar anorectal pain has a good clinical effect , which can improve patients ' quality of life.

12.
Article in Chinese | WPRIM | ID: wpr-816061

ABSTRACT

OBJECTIVE: To evaluate the predictive value of various gastric cancer risk scoring systems based on the detection of pepsinogen and gastrin 17 for the risk of developing gastric cancer. METHODS: One hundred and forty-four patients were enrolled into the study from the First Affiliated Hospital of Anhui Medical University between April 2018 and October 2018.Among them, seventyfour patients were diagnosed with early gastric cancer while seventy patients didn't have gastric cancer(control group). The levels of serum pepsinogen I(PGI)/pepsinogen II(PGII), gastrin-17(G-17) and H.pylori antibody were measured. Patients were scored according to the Japanese ABC method, the modified ABC method, and the Chinese new gastric cancer risk scoring system. Compare the accuracy of the three methods for predicting the risk of developing gastric cancer. RESULTS: Compared with the control group, there was no significant difference in PG levels between the two groups, the serum G-17 levels were lower in gastric cancer patients than those in control group(P<0.05). According to the ABC method, the incidence rates of gastric cancer in the four groups of ABCD were 48.6%,59.4%, 0.0% and 100% respectively; the incidence rates of gastric cancer in the three groups of modified ABC method were 57.6%, 35.9% and 50% respectively. The cut-off value of new gastric cancer risk scoring system to diagnose gastric cancer was 11. The sensitivity,specificity, accuracy, positive predictive value and negative predictive value were 64.8%, 71.4%, 68.1%, 70.6 and 65.8% respectively. But in the low risk group, there were 26 cases(35.1%) of gastric cancer. Comparing the low-risk with the middle-high-risk population of gastric cancer, there were more females in the low risk group. CONCLUSION: The Japanese ABC method and the modified ABC method have value for limited screening gastric cancer and are not suitable for China's national conditions. The screening efficacy of the new gastric cancer scoring system for gastric cancer is significantly higher than the other two methods; however we should be vigilant when it is used in women with low risk.

13.
Chinese Medical Journal ; (24): 1974-1982, 2019.
Article in English | WPRIM | ID: wpr-774697

ABSTRACT

OBJECTIVE@#Ultrasound imaging is well known to play an important role in the detection of thyroid disease, but the management of thyroid ultrasound remains inconsistent. Both standardized diagnostic criteria and new ultrasound technologies are essential for improving the accuracy of thyroid ultrasound. This study reviewed the global guidelines of thyroid ultrasound and analyzed their common characteristics for basic clinical screening. Advances in the application of a combination of thyroid ultrasound and artificial intelligence (AI) were also presented.@*DATA SOURCES@#An extensive search of the PubMed database was undertaken, focusing on research published after 2001 with keywords including thyroid ultrasound, guideline, AI, segmentation, image classification, and deep learning.@*STUDY SELECTION@#Several types of articles, including original studies and literature reviews, were identified and reviewed to summarize the importance of standardization and new technology in thyroid ultrasound diagnosis.@*RESULTS@#Ultrasound has become an important diagnostic technique in thyroid nodules. Both standardized diagnostic criteria and new ultrasound technologies are essential for improving the accuracy of thyroid ultrasound. In the standardization, since there are no global consensus exists, common characteristics such as a multi-feature diagnosis, the performance of lymph nodes, explicit indications of fine needle aspiration, and the diagnosis of special populations should be focused on. Besides, evidence suggests that AI technique has a good effect on the unavoidable limitations of traditional ultrasound, and the combination of diagnostic criteria and AI may lead to a great promotion in thyroid diagnosis.@*CONCLUSION@#Standardization and development of novel techniques are key factors to improving thyroid ultrasound, and both should be considered in normal clinical use.

14.
China Pharmacy ; (12): 1640-1643, 2018.
Article in Chinese | WPRIM | ID: wpr-704860

ABSTRACT

OBJECTIVE:To establish HPLC fingerprint of Homalocladium platycladum,and to carry on the cluster analysis. METHODS:HPLC method was adopted. The determination was performed on Ultimate C18 column with mobile phase consisted of acetonitrile-0.1% phosphoric acid(gradient elution)at the flow rate of 0.5 mL/min. The detection wavelength was set at 360 nm, and column temperature was 28 ℃. The sample size was 10 μL. Using quercetin as reference substance,HPLC chromatograms of 13 batches of samples were determined. The similarity evaluation was carried out by using Similarity Evaluation System for TCM Chromatographic Fingerprint(2012 edition)to determine common peak. Cluster analysis were also conducted. RESULTS:A total of 12 common peaks were established in HPLC fingerprints of 13 batches of samples. The similarity was higher than 0.90. After validation,HPLC chromatograms of 13 batches of sample were in good agreement with control fingerprint. 13 batches of medicinal materials were clustered into 2 categories;S4,S6 and S10 were clustered into one category,and the rest were a category. CONCLUSIONS:Established fingerprint and cluster analysis results can provide reference for quality evaluation of H. platycladum and its exploitation and utilization.

15.
China Pharmacy ; (12): 1462-1466, 2018.
Article in Chinese | WPRIM | ID: wpr-704822

ABSTRACT

OBJECTIVE:To analyze the current status and problems of medicine purchase and distribution of county,township public medical institutions in Hubei province,and to propose targeted policy recommendations. METHODS:By stratified typical sampling,medicine data of 3 county medical institutions and 40 township medical institutions in 3 counties of Hubei province were collected from medicine bidding and purchasing platform of county health and family planning bureau and hospital information system (HIS). Medicine purchase and distribution,distribution rate,purchase and distribution of essential medicine,Chinese patent medicine and injection,general information of top 10 medicines in the list of purchase amount were analyzed in different levels of medical institutions. RESULTS:The medicine purchase and distribution amount of the township medical institutions were lower than those of county medical institutions, but the total amount and distribution rate were higher than county medical institutions. The purchase amount of essential medicine accounted for nearly 3/4 of the total amount (90.6% of the township medical institutions,and 48.4% of the county medical institutions);the purchase amount of Chinese patent medicine accounted for about 1/4 of the total amount (35.4% of the township medical institutions,15.4% of the county medical institutions);purchase amount of injection accounted for nearly half (34.6% of the township medical institutions,and 59.3% of the county medical institutions). The distribution rates of essential medicine,Chinese patent medicine and injection were 93.0%,93.3%,and 93.2%in township medical institutions,and 81.8%,78.6% and 79.6% in county medical institutions,respectively. The rate of medicine distribution of township medical institutions was higher than that of the county medical institutions. The top 10 medicines in the list of purchase amount included 6 kinds of antibiotics,and the top 5 medicines included 2 kinds of injection. CONCLUSIONS:The policy of essential medicine purchase is well implemented in Hubei province,and purchase rate of essential medicine meet the policy requirements(40%-50%);but the proportion of injection purchase can partly reflect the high usage of injection,which may indicate the abuse of injection, and Chinese patent medicine has become an integral part of medicine purchase. Moreover, medicines still have the status of distribution untimely,and medicine distribution of the township medical institutions is better than that of county medical institutions.

16.
Chinese Health Economics ; (12): 11-13, 2018.
Article in Chinese | WPRIM | ID: wpr-703467

ABSTRACT

The reform of public hospital was the focus and difficulty in the new round of health care system reform.More complex situations and more arduous challenges,which occurred in deepening the reform,were gradually leading the solution retransfer to the analysis of fundamental orientation mechanisms of public hospitals in theoretical and practical dimension.The co-existence of policy orientation,social orientation and self-orientation,relying on their own way or combined effect,made a significant impact on the further development of public hospitals.

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Article in Chinese | WPRIM | ID: wpr-699686

ABSTRACT

Objective To develop a remote diabetic retinopathy (DR) screening system and to evaluate the effectiveness of the screening system in community.Methods A cross-sectional study was carried out under the informed consent of subjects in Peking University People's Hospital and Beijing Xicheng District Desheng Community Health Service Center from June 2015 to December 2016.A remote DR screening system was established in Peking University People's Hospital and Beijing Xicheng District Desheng Community Health Service Center during June 2015 to December 2016.Based on non-mydriatic digital eye fundus camera photography and the internet transmission technology,anterior ocular segment and fundus images of 2 473 eyes from 1 355 community subjects with type 2 diabetes mellitus were transmitted from Beijing Xicheng District Desheng Community Health Service Center to the reading center of Peking University People's Hospital,and the results were provided to the subjects after analysis,including visual examination,diagnosis and follow-up rate of the subjects,the agreement between remote screening system and conventional screening method was analyzed and compared.Results The visual acuities of the 2 473 eyes of 1 355 subjects were obtained by trained community physician,and the visual acuity was ≤0.05 in 103 eyes (4.2%),>0.05-0.3 in 780 eyes (31.5%),>0.3 in 1 590 eyes (64.3%).A good consistency was found in the diagnosis and grading of DR (Kappa value =0.895) and in diagnosis of macular disorder (Kappa value =0.763)between the remote screening system and conventional screening method.In addition,the diagnosis results of retinal photocoagulation were consistent between the two methods (Kappa value =1.000).The mean duration of the remote screening system for one subject was 10 minutes,which was shorter than 23 minutes of conventional screening method.The follow-up rate of remote screening system was 75.2%.Conclusions There is a high consistency in the DR diagnosis and evaluation between the remote non-mydriatic screening system and conventional screening method.The screening program with follow-up requests has a satisfying follow-up rate,which could meet the demand of DR screening.

18.
Article in Chinese | WPRIM | ID: wpr-698677

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BACKGROUND:Collagen-bioglass-polycaprolacton (COL-BG-PCL) composites have good biocompatibility, mechanical properties and biodegradability that are beneficial to cell adhesion, proliferation and angiogenesis. OBJECTIVE:To study the effect of COL-BG-PCL bioactive scaffold on the proliferation, migration and differentiation of human dental pulp cells (hDPCs). METHODS:hDPCs were isolated and cultured on the COL-BG-PCL bioactive scaffold. MTT, cell scratch test and enzyme-linked immunosorbent assay (ELISA) assay were used to detect the proliferation, migration and differentiation abilities of hDPCs before and at 1, 3, 7, 14, 24 days after inoculation onto the COL-BG-PCL bioactive scaffold. RESULTS AND CONCLUSION:Compared with the cells without inoculation onto the COL-BG-PCL bioactive scaffold, (1) the proliferation ability of the cells cultured on the COL-BG-PCL scaffold was significantly enhanced (P<0.01), and with the prolongation of the inoculation time, the cell proliferation ability was gradually increased; (2) the cell migration ability of the cells cultured on the COL-BG-PCL scaffold was significantly enhanced (P<0.01), and with the prolongation of the inoculation time, the migration ability of the cells cultured on the COL-BG-PCL scaffold was gradually increased; (3) the level of alkaline phosphatase in the supernatant of the cells cultured on the COL-BG-PCL scaffold was significantly increased (P<0.01), and with the prolongation of the inoculation time, the level of alkaline phosphatase in the supernatant was gradually increased. In summary, the COL-BG-PCL scaffold can promote the proliferation, migration and differentiation of hDPCs.

19.
Article in Chinese | WPRIM | ID: wpr-695920

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Objective To investigate the effect of electroacupuncture on hypothalamic insulin receptor substrate 1 (IRS-1) in a rat model of type 2 diabetes mellitus (T2DM). Methods Sixty Wistar rats were randomized to a normal group (15 rats) and an observation group (45 rats). In the observation group, a rat model of T2DM was made by high-energy diet induction. After the model was successfully made 8 weeks later, the observation group was randomized to model making, treatment and blocker groups, 15 rats each. The treatment group received electroacupuncture and the blocker group, electroacupuncture plus intraventricular perfusion of phosphatidylinositol 3-hydroxyl kinase (PI3K) blocker. After 8 weeks of treatment, fasting plasma glucose (FPG) was measured using a glucometer, fasting insulin (Fins) was determined by ELISA, insulin resistance index (IRI) was calculated and IRS-1 expression was examined by SABC immunohistochemistry assay in every group of rats. Results FPG and Fins increased significantly (both P<0.01) and IRI and IRS-1 expression decreased significantly (P<0.01) in the model making group compared with the normal group. FPG and Fins decreased significantly (both P<0.01) and IRI and IRS-1 expression increased significantly (P<0.01) in the treatment group compared with the model making group. FPG and Fins decreased significantly (P<0.05, P<0.01) and IRI and IRS-1 expression increased significantly (P<0.01) in the treatment group compared with the blocker group. Conclusion Electroacupuncture can improve FPG, Fins and insulin sensitivity by regulating hypothalamic IRS-1 expression in T2DM rats.

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Shanghai Journal of Preventive Medicine ; (12): 1016-1019,1024, 2018.
Article in Chinese | WPRIM | ID: wpr-789461

ABSTRACT

[Objective] To investigate the prevalence, drug resistance and molecular characteristics of MRSA in hospital environment, so as to provide basis for prevention and control of nosocomial MRSA infection. [Methods]Specimens from Dec 2014 to May 2015 were collected from a tertiary hospital in Jing'an District of Shanghai and MRSA strains isolated from hospital environment and characterized by antimicrobial susceptibility testing and pulsed-field gel electrophoresis (PFGE). [Results]From 316 specimens were detected 46 MRSA strains with contamination rate being 14.6% (46/316). And 22 (7.0%) were detected to be carriers of MRSA on the surfaces of ICU environment. MRSA had higher resistant rate to cefuroxime, levofloxacin, ciprofloxacin, Ampicillin/sulbactam, erythrocin, gentamycin than MSSA, and the difference was statistically significant (P<0.01). A total of 8 PFGE patterns were identified among the 14 MRSA isolates, which were mostly similar from one clone. [Conclusion] MRSA strains isolated from ICU in this hospital are multi-resistant to β-lactam antibiotics, quinolones and macrolides. There is clonal pollution in the environment. It is necessary to decrease the contamination rates between patients and environment, health care workers and environment, also it is worthwhile to increase the disinfection rate of environment.

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