Vascular endothelial growth factor (VEGF) is the main regulator of physiological angiogenesis during embryonic development, bone growth, and reproductive function, and it also participates in a series of pathological changes. Traditional Chinese medicine (TCM), with a history of more than 2000 years, has been widely used in clinical practice, while the exploration of its mechanisms has only begun. This review summarizes the research of recent years on the influence of TCM on VEGF. It is found that many Chinese medicines and recipes have a regulatory effect on VEGF, indicating that Chinese medicine has broad prospects as a complementary and alternative therapy, providing new treatment ideas for clinical applications and the theoretical basis for research on the mechanisms of TCM.
Subject(s)Drugs, Chinese Herbal/therapeutic use , Medicine, Chinese Traditional , Vascular Endothelial Growth Factor A
With the recent upsurge of studies in the field of microbiology, we have learned more about the complexity of the gastrointestinal microecosystem. More than 30 genera and 1000 species of gastrointestinal microflora have been found. The structure of the normal microflora is relatively stable, and is in an interdependent and restricted dynamic equilibrium with the body. In recent years, studies have shown that there is a potential relationship between gastrointestinal microflora imbalance and gastric cancer (GC) and precancerous lesions. So, restoring the balance of gastrointestinal microflora is of great significance. Moreover, intervention in gastric premalignant condition (GPC), also known as precancerous lesion of gastric cancer (PLGC), has been the focus of current clinical studies. The holistic view of traditional Chinese medicine (TCM) is consistent with the microecology concept, and oral TCM can play a two-way regulatory role directly with the microflora in the digestive tract, restoring the homeostasis of gastrointestinal microflora to prevent canceration. However, large gaps in knowledge remain to be addressed. This review aims to provide new ideas and a reference for clinical practice.
Subject(s)Drugs, Chinese Herbal/therapeutic use , Gastrointestinal Microbiome , Humans , Medicine, Chinese Traditional , Precancerous Conditions/pathology , Stomach Neoplasms/pathology
It has been confirmed that the body′s response to hepatitis C virus (HCV) is not only associated with virus, but also associated with some cytokines and their gene polymorphisms. In this paper, the current research on some cytokines associated with HCV and their gene polymorphisms is reviewed. And it is shown that interleukin-28B is closely associated with the course and prognosis of chronic hepatitis C (CHC). Therefore, it is of great significance for the clinical diagnosis and treatment of CHC to investigate host cytokines and their gene polymorphisms.