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Kampo Medicine ; : 361-366, 1992.
Article in Japanese | WPRIM | ID: wpr-367932


Abstract Combined treatment with high-dose methylprednisolone and Kampoherbal medicine (Xiao-Chai-Hu-Tang and Jia-Wei-Gui-Pi-Tang) brought about a striking clinical improvement in a 24-year-old woman with severe hepatitis-associated aplastic anemia. Laboratory findings on admission were summarized as follows: granulocytes 325/μ<i>l</i>, erythrocytes 2, 450, 000/μ<i>l</i>, platelets 10, 000/μ<i>l</i>, bone marrow nucleated cells 27, 000/μ<i>l</i>, and GPT 569IU/<i>l</i>. Neither anti-lymphocyte globulin, high-dose methylprednisolone alone nor oxymetholone was effective on any hematological finding although intravenous administration of high-dose glycyrrhizin improved the liver dysfunction. The patient needed repeated transfusions of leukocyte-poor washed red blood cells and HLA-matched platelet concentrates for a period of 1.5 years until the hematopoietic function recovered 3 months after combined treatment with high-dose methylprednisolone and Kampo-herbal medicine. Laboratory findings on discharge were as follows: granulocytes 1, 050/μ<i>l</i>, erythrocytes 3, 460, 000/μ<i>l</i>, reticulocytes 100, 000/μ<i>l</i>, platelets 47, 000/μ<i>l</i>, bone marrow nucleated cells 118, 000/μ<i>l</i>, and GPT 52IU/<i>l</i>. Six months later hematopoietic depression recurred, and this combined treatment was performed again with favorable response.