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Article in Chinese | WPRIM | ID: wpr-907062


Objective @#To examine the effect of moderate aerobic exercise on the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) in patients with hypercholesterolemia, so as to provide insights into ASCVD prevention.@*Methods @#The patients with hypercholesterolemia admitted to the Affiliated Hospital of Hebei University from September 2019 to September 2020 were recruited and randomly assigned into the intervention group and the control group using a random number table. Participants in both groups received routine lipid-lowering therapy and health education, and participants in the intervention group were given additional interventions of moderate aerobic exercise. Serum lipid levels were measured before and after 12 weeks of interventions. The 10-year risk of developing ASCVD was evaluated in both groups following interventions.@*Results @#There were 50 participants with hypercholesterolemia in each of the intervention and control groups. The mean age was ( 38.80±1.42 ) years in the intervention group and ( 37.14±1.23 ) years in the control group, and males were accounted for 46.00% and 40.00%, respectively. The increase in high-density lipoprotein cholesterol ( HDL-C ), the reduction in total cholesterol ( TC ), triglyceride ( TG ), low-density lipoprotein cholesterol ( LDL-C ) and the 10-year risk of ASCVD were all significantly greater in the intervention group than those in the control group before and after the interventions ( P<0.05 ).@*Conclusion @#Moderate aerobic exercise may reduce the 10-year risk of ASCVD through regulating blood lipid levels.

Fisioter. Mov. (Online) ; 35: e35109, 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1364856


Abstract Introduction: Cardiovascular diseases (CVD) figure among the most significant causes of morbidity and mortality in the world and, among genetic factors, the literature has demonstrated the crucial role of miRNAs and the relationship of physical activity with this pathology. Objective: To investigate the relationship between the functional capacity of exercise, the level of physical activity, and the polymorphism in the miRNA-146a gene in elderly individuals with and without CVD. Methods: This study, developed in a city in the southern region of Brazil, is characterized as cross-sectional. The sample for this study comprised 342 participants, aged 60 or over. The following aspects were analyzed: anthropometric characteristics, genetic profiles, diagnosis of CVD, functional capacity, and the level of physical activity. Results: A statistically significant association was observed between CVD and body mass index (BMI) (א² = 14.278; p = 0.0003), and 40.6% of elderly individuals with CVD were obese, while 31.5% of the normally developed elderly participants presented normal BMI. However, the genotype frequencies (p = 0.546; א² = 1.211) and 6MWT (p = 0.311; א² = 1.025) did not show a statistically signifi-cant association with CVD. Conclusion: Our results suggest that the polymorphism in the miRNA-146A (rs2910164) and functional capacity are not associated with CVD in the elderly. However, the BMI did demonstrate an association with this disease.

Resumo Introdução: As doenças cardiovasculares (DCV) figuram entre as causas mais significativas de morbimortalidade no mundo e, dentre os fatores genéticos, a literatura tem demonstrado o papel crucial dos miRNAs e a relação da atividade física com essa patologia. Objetivo: Investigar a relação entre a capacidade funcional do exercício, o nível de atividade física e o polimorfismo no gene miRNA-146a em idosos com e sem DCV. Métodos: Este estudo, desenvolvido em um município da região sul do Brasil, caracteriza-se como transversal. A amostra deste estudo foi composta por 342 participantes, com idade igual ou superior a 60 anos. Foram analisados ​​os seguintes aspectos: características antropométricas, perfis genéticos, diagnóstico de DCV, capacidade funcional e nível de atividade física. Resultados: Observou-se associação estatisticamente significativa entre DCV e índice de massa corporal (IMC) (א² = 14,278; p = 0,0003), sendo que 40,6% dos idosos com DCV eram obesos, enquanto 31,5% dos idosos normalmente desenvolvidos apresentaram IMC normal. No entanto, as frequências genotípicas (p = 0,546; א² = 1,211) e TC6 (p = 0,311; א² = 1,025) não mostraram associação estatisticamente significante com DCV. Conclusão: Os resultados do presente estudo sugerem que o polimorfismo no miRNA-146A (rs2910164) e a capacidade funcional não estão associados à DCV em idosos; no entanto, o IMC demonstrou associação com essa doença.

Rev. Soc. Bras. Med. Trop ; 55(supl.1): e0263, 2022. graf
Article in English | LILACS-Express | LILACS | ID: biblio-1356784


Abstract INTRODUCTION: To better understand trends in the main cause of death in Brazil, we sought to analyze the burden of cardiovascular risk factors (RF) and cardiovascular diseases (CVD) attributable to specific RFs in Brazil from 1990 to 2019, using the estimates from the GBD 2019 study. METHODS: To estimate RF exposure, the Summary Exposure Value (SEV) was used, whereas for disease burden attributed to RF, mortality and disability-adjusted life-years (DALY) due to CVD were used. For comparisons over time and between states, we compared age-standardized rates. The sociodemographic index (SDI) was used as a marker of socioeconomic conditions. RESULTS: In 2019, 83% of CVD mortality in Brazil was attributable to RF. For SEV, there was a reduction in smoking and environmental RF, but an increase in metabolic RF. High systolic blood pressure and dietary risks continue to be the main RF for CVD mortality and DALY. While there was a decline in age-standardized mortality rates attributable to the evaluated RF, there was also a stability or increase in crude mortality rates, with the exception of smoking. It is important to highlight the increase in the risk of death attributable to a high body mass index. Regarding the analysis per state, SEVs and mortality attributable to RF were higher in those states with lower SDIs. CONCLUSIONS: Despite the reduction in CVD mortality and DALY rates attributable to RF, the stability or increase in crude rates attributable to metabolic RFs is worrisome, requiring investments and a renewal of health policies.

Rev. colomb. reumatol ; 28(supl.1): 21-30, Dec. 2021. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1360998


ABSTRACT Cardiovascular disease (CVD), particularly coronary heart disease and stroke, is one of the most important causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). The increased prevalence of CVD and subclinical atherosclerosis, even after adjustment for traditional risk factors, are well established. Several associations with disease-related clinical, genetic and immunological features have been identified. The SLE-specific stratification algorithms with emphasis on composite risk-assessment scores including both traditional risk factors and novel biomarkers is recommended. The clinical complexity of accelerated atherosclerosis will most likely require an integrated approach for the identification, treatment, and intensive study into this aspect of SLE that will ultimately lead to improved cardiovascular outcomes for these patients.

RESUMEN La enfermedad cardiovascular (ECV), en particular la enfermedad coronaria y el ictus, es una de las causas más importantes de morbimortalidad en pacientes con lupus eritematoso sistémico (LES). El aumento en la prevalencia de la ECV y de la aterosclerosis subclínica, aun después del ajuste de los factores de riesgo tradicionales, está claramente establecida. Se han identificado diversas asociaciones con características clínicas, genéticas e inmunológicas relacionadas con la enfermedad. Se recomienda el uso de los algoritmos de estratificación específicos para el LES, con énfasis en los puntajes compuestos de evaluación de riesgo, incluyendo tanto los factores de riesgo tradicionales como los nuevos biomarcadores. La complejidad clínica de la aterosclerosis acelerada muy probablemente requerirá un abordaje integral para la identificación, el tratamiento y el estudio intensivo de este aspecto del LES, que en última instancia permita obtener mejores desenlaces cardiovasculares en estos pacientes.

Rev Bras Hipertens ; 28(4): 283-287, 20211210.
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1367465


A doença cardiovascular (DCV) representa um fardo individual e social em pacientes com diabetes mellitus tipo 2 (DM2). A diabetes é uma doença crônica onerosa do ponto de vista social e econômico. O seu tratamento inclui medidas não farmacológicas, como dieta e exercício físico, bem como a adição de medicamentos em pacientes que não atingem controle glicêmico satisfatório através de medidas comportamentais. Medicamentos da classe inibidores de SGLT2 (iSGLT2), objeto deste manuscrito, têm sido associados com a redução de eventos cardiovasculares e mortalidade, além de redução da pressão arterial e peso, sem conferir aumento de risco de hipoglicemia

Cardiovascular disease (CVD) represents an individual and social burden in patients with type 2 diabetes mellitus (T2DM). Diabetes is a chronic, socially and economically costly disease. Its treatment includes non-pharmacological measures, such as diet and exercise, as well as the addition of medication in patients who do not achieve satisfactory glycemic control through behavioral approach. Drugs as SGLT2 inhibitor (SGLT2i), object of this manuscript, have been associated with a reduction in cardiovascular events and mortality, in addition to a reduction in blood pressure and weight, without increasing the risk of hypoglycemia.

Arq. bras. cardiol ; 117(4): 701-712, Oct. 2021. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1345245


Resumo Fundamento: Indicadores antropométricos são utilizados na prática clínica e em estudos epidemiológicos para rastreamento de fatores de risco à saúde. Objetivo: Avaliar o poder discriminatório individual do Índice de Adiposidade Corporal (IAC), do Índice de Massa Corporal (IMC), da Circunferência da Cintura (CC) e da Razão Cintura-Quadril (RCQ) para identificar risco coronariano e investigar se a combinação de indicadores antropométricos de obesidade geral e central melhora a capacidade preditiva em adultos. Métodos: Avaliou-se 15 092 participantes (54,4% mulheres) com idades entre 35-74 anos na linha de base do ELSA-Brasil. Indivíduos em risco coronariano foram identificados pelo Escore de Risco de Framingham, e divididos em risco muito alto (RMA20%) e risco alto (RA10%). Medidas de acurácia diagnóstica e áreas sob curvas ROC (AUC) foram analisadas. Associações foram testadas por regressão de poisson com variância robusta, conforme sexo e idade. Foi adotada significância estatística de 5%. Resultados: A RCQ apresentou melhor poder discriminatório para RMA20% em todos os grupos, com maior capacidade preditiva nas mulheres (AUC: 0,802; IC95%: 0,748-0,856 vs 0,657; IC95%: 0,630-0,683 nas faixas etárias 35-59 anos e AUC: 0,668; IC95%: 0,621-0,715 vs 0,611; IC95%: 0,587-0,635 nas faixas etárias 60-74 anos). As combinações IAC+RCQ e IMC+RCQ apresentaram melhor poder preditivo em homens e mulheres, respectivamente. Combinações entre indicadores de obesidade geral e central estiveram mais fortemente associadas com RMA20% e RCA10% em todos os estratos. Conclusões: Indicadores combinados tiveram melhor capacidade preditiva do que um indicador isoladamente, sendo IAC+RCQ e IMC+RCQ melhores estimadores de risco coronariano em homens e mulheres, respectivamente. RCQ teve melhor desempenho individual.

Abstract Background: Anthropometric indicators have been used in clinical practice and epidemiological studies for screening of health risk factors. Objectives: To evaluate the individual discriminatory power of body adiposity index (BAI), body mass index (BMI), waist circumference (WC) and waist-hip-ratio (WHR) to identify individuals at risk for coronary heart disease and to evaluate whether combinations of anthropometric indicators of overall obesity with indicators of central obesity improve predictive ability in adults. Methods: A total of 15,092 participants (54.4% women) aged 35-74years were assessed at baseline of the ELSA-Brasil study. Individuals at risk for coronary heart disease were identified using the Framingham risk score and divided into very-high risk (VHR 20%) and high risk (HR10%). Measures of diagnostic accuracy and area under the ROC curves (AUC) were analyzed. Associations were tested using Poisson regression analysis with robust variance, according to age and sex. Statistical significance was set at 5%. Results: WHR showed the highest discriminatory power for VHR20% in all groups, with higher predictive ability in women (AUC: 0.802; 95%CI: 0.748-0.856 vs 0.657; 95%CI: 0.630-0.683 in the age range of 35-59 years, and AUC: 0.668; 95%CI: 0.621-0.715 vs 0.611; 95%CI: 0.587-0.635 in the age range of 60-74 years). BAI + WHR and BMI + WHR had the highest predictive power in men and women, respectively. Combinations of indicators of overall obesity with indicators of central obesity were more strongly associated with VHR20% and HR10% in all subgroups. Conclusion: Combined indicators had greater predictive ability than indicators taken individually. BAI+ WHR and BMI + WHR were the best estimators of coronary risk in men and women, respectively, and WHR had the best individual performance.

Humans , Male , Female , Adult , Obesity, Abdominal/complications , Obesity, Abdominal/epidemiology , Body Mass Index , Risk Factors , Waist-Hip Ratio , Waist Circumference , Middle Aged , Obesity/complications , Obesity/epidemiology
Revista brasileira de ciência e movimento ; 29(1): [1-28], nov. 2021. tab, ilus
Article in Portuguese | LILACS | ID: biblio-1348230


: O exercício físico, em especial a corrida de rua tem sido recomendada para prevenção e tratamento de doenças crônicas não transmissíveis. O objetivo desta revisão sistemática foi verificar os efeitos de diferentes métodos de treinamento sobre os indicadores cardiometabólicos de corredores recreacionais. As bases de dados eletrônicas utilizadas na presente pesquisa foram: PUBMED, SCIENCE DIRECT, LILACS e COCHRANE LIBRARY, usando os descritores agrupados segundo o método PICO; População ("adults" OR "young adult" OR "middle aged") AND Intervenção ("endurance training" OR "aerobic training" OR "running") OR Comparação ("recreational runners" OR "jogging") AND Outcome/Desfecho ("cardiovascular risk factors" OR "cardiometabolic risk factors" OR "metabolic syndrome"). Na seleção os artigos foram excluídos por título, resumo e texto. Obteve-se um total de 813 artigos encontrados, no qual nove (9) preencheram os critérios de inclusão e baixo risco de viés de acordo com a Escala Testex. Foram encontrados três métodos de treinamento: Combinado (Contínuo +Intervalado); Contínuo e Intervalado. Considerando a somatória das amostras dos nove estudos, um total de 604 indivíduos (466 homens e 138 mulheres) participaram dos ensaios. Os diferentes métodos de treinamentos resultaram na redução dos níveis de triglicerídeos, insulina e glicose e na redução do colesterol total e LDL, e consequentemente o aumento do HDL. Na composição corporal houve diminuição significativa do peso e da gordura corporal, do IMC, na medida da circunferência da cintura, e no aumento da capacidade aeróbia (VO2). Concluiu-se que os treinamentos combinado, contínuo e intervalado podem ser aplicados para melhora dos indicadores cardiometabólicos, cada um dentro da sua especificidade de frequência, volume e intensidade.(AU)

Physical exercise, especially running, has been recommended for the prevention and treatment of chronic non-communicable diseases. The objective of this systematic review was to verify the effects of different training methods on the cardiometabolic indicators of recreational runners. The electronic databases used in the present research were: PUBMED, SCIENCE DIRECT, LILACS and COCHRANE LIBRARY, using the descriptors grouped according to the PICO method; Population ("adults" OR "young adult" OR "middle aged") AND Intervention ("endurance training" OR "aerobic training" OR "running") OR Comparison ("recreational runners" OR "jogging") AND Outcome / Outcome ("Cardiovascular risk factors" OR "cardiometabolic risk factors" OR "metabolic syndrome"). In the selection, articles were excluded by title, abstract and text. A total of 813 articles were obtained, in which nine (9) met the inclusion criteria and low risk of bias according to the Testex Scale. Three training methods were found: Combined (Continuous + Interval); Continuous and Interval. Considering the sum of the samples from the nine studies, a total of 604 individuals (466 men and 138 women) participated in the trials. The different training methods resulted in a reduction in the levels of triglycerides, insulin and glucose and in the reduction of total cholesterol and LDL, and consequently an increase in HDL. In body composition, there was a significant decrease in weight and body fat, in BMI, as measured by waist circumference, and in increased aerobic capacity (VO2). It is concluded that combined, continuous and interval training can be applied to improve cardiometabolic indicators, each within its specific frequency, volume and intensity.(AU)

Humans , Male , Female , Adult , Middle Aged , Aged , Running , Physical Fitness , Endurance Training , Triglycerides , Body Composition , Exercise , Cholesterol , Metabolic Syndrome , Diabetes Mellitus , Fats , Arterial Pressure , High-Intensity Interval Training , Noncommunicable Diseases , Heart Disease Risk Factors , Cardiometabolic Risk Factors , Glucose , Insulin , Jogging
Rev. colomb. cardiol ; 28(5): 404-409, sep.-oct. 2021.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1357206


Resumen Introducción: La enfermedad cardiovascular en mujeres ha sido un apartado con diversas investigaciones que han intentado llegar a los factores de riesgo más determinantes o las vías moleculares más específicas para explicar el riesgo aumentado que poseen las mujeres respecto a los hombres. Objetivo: Dar una visión global de esta situación al lector, involucrando especialmente aquella población de mujeres que padece diabetes mellitus tipo 2, cuya condición es un factor de riesgo independiente para el desarrollo de enfermedad cardiovascular, de gran costo y morbimortalidad mundiales. Métodos: Se realizó una búsqueda en PubMed y Google Scholar con términos MeSH y términos comunes y se obtuvieron algunas referencias cruzadas a criterio de los autores. Conclusiones: Es necesario implementar en la práctica médica diaria un contexto específico de prevención de riesgo cardiovascular mediante programas de educación continuada o por medio de las entidades prestadoras de servicios de salud para evitar la progresión de enfermedad cardiovascular en las mujeres diabéticas antes de llegar a desenlaces mayores y potencialmente fatales.

Abstract Introduction: Cardiovascular disease in woman has been an issue with plenty of investigations towards the finding of the most determinant risk factors o the specific molecular paths to explain the increased risk in women compared to men. Objective: To give to the reader a global vision of this situation, involving specially the type 2 diabetes mellitus woman population, whose condition is an independent risk factor to the development of the cardiovascular disease with great cost and morbidity and mortality worldwide. Methods: A PUBMED and Google Scholar search was performed with MeSH and common terms and were obtained some cross-references at the discretion of the authors. Conclusions: It is necessary to implement a specific context of cardiovascular risk prevention in daily medical practice through continuing education programs or through health service providers to prevent the progression of cardiovascular disease in diabetic women before reaching major outcomes and potentially fatal.

Rev. colomb. cardiol ; 28(5): 431-437, sep.-oct. 2021. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1357209


Resumen Introducción: Los estudios bibliométricos permiten realizar un análisis cuantitativo y cualitativo de la producción científica en un campo determinado. En el área de la cardiología, la producción científica ha crecido sustancialmente durante las últimas décadas; sin embargo, existe poca información acerca del manejo integral de la insuficiencia cardiaca con fracción de eyección preservada (ICFEp). Objetivo: Realizar un análisis bibliométrico que proporcione una evaluación detallada del nivel de producción científica de la ICFEp. Método: Estudio bibliométrico descriptivo en el que se realizó una búsqueda en la literatura científica en los últimos 30 años respecto a la ICFEp, para lo cual se utilizó la estrategia de búsqueda "heart failure" AND "preserved ejection fraction" entre 1988 y 2018 en las bases de datos Web of Science, Scopus y Medline a partir de FABUMED y PubReMiner. Resultados: Se encontraron 2830, 4136 y 7943 publicaciones en las bases de datos Medline, Scopus y Web of Science, respectivamente. Los países destacados por su volumen de publicación fueron los Estados Unidos, el Reino Unido y Alemania. En Latinoamérica, los países más productivos fueron Brasil, Argentina y Chile, mientras que Colombia solo tuvo una publicación. Conclusiones: Este análisis bibliométrico es pionero en señalar la evolución de la investigación científica de la ICFEp en los últimos 30 años. Los resultados obtenidos representan un incentivo a la comunidad científica para priorizar la investigación sobre la ICFEp con el fin de mejorar el abordaje integral de los pacientes y, con ello, su calidad de vida.

Abstract Introduction: Bibliometric studies are defined as the quantitative and qualitative analysis of scientific production in each field. The scientific production in the area of cardiology has had a substantial growth during the last decades. Despite this, there is currently little information about heart failure with preserved ejection fraction (HFpEF). Objective: To provide a detailed assessment of the current status and level of scientific production of HFpEF over the past 30 years. Method: Bibliometric study based in scientific literature concerning HFpEF for the period of 1988 - 2018 using the terms "heart failure" AND "preserved ejection fraction" in the databases of the Web of Science, Scopus and Medline using FABUMED and PubReMiner. Results: We found 2830, 4136 and 7943 publications in Medline, Scopus and Web of Science databases, respectively. The countries with higher scientific production in general were: United States, United Kingdom and Germany. In Latin America, the most productive countries were Brazil, Argentina and Chile. Colombia only had one publication. Conclusions: This is the first bibliometric analysis to highlight the production, evolution and current situation of scientific research about the HFpEF in the last 30 years, a call is made to the scientific community worldwide and especially in our country, Colombia, to focus in the scientific production on this subject. The above mentioned, in order to clarify the pathophysiology, reduce morbidity, mortality and improve the quality of life of patients suffering from HFpEF.

Rev. colomb. cardiol ; 28(5): 464-472, sep.-oct. 2021. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1357214


Resumen Las enfermedades periodontales son infecciones que involucran al tejido de soporte dental, inducen inflamación y pueden provocar la pérdida dental si no son controladas. La enfermedad cardiovascular se presenta por trastornos cardiacos y de vasos sanguíneos, y es la principal causa de muerte en todo el mundo. La periodontitis clínica se asocia con un mayor riesgo de enfermedad cardiovascular debido a la inflamación sistémica como vínculo etiopatogénico; por infestación metastásica, puede llegar a diferentes órganos anatómicos y ocasionar cambios patológicos. El consultorio odontológico es un lugar adecuado para tomar medidas de prevención en los pacientes, tanto en el ámbito oral como en la salud cardiovascular. Se realizó una búsqueda bibliográfica en PubMed, Cochrane, Google Scholar y SciELO, y en este artículo se hace una revisión de la literatura sobre la periodontitis y su relación con las enfermedades cardiovasculares y la promoción de la salud cardiovascular.

Abstract Periodontal diseases are infections that involve the dental support tissue that induce inflammation and can cause tooth loss if it is not controlled. Cardiovascular disease occurs due to heart and blood vessel disorders, it is the leading cause of death worldwide. Clinical periodontitis is associated with an increased risk of cardiovascular diseases through systemic inflammation as an etiopathogenic link; due to metastatic infestation, they can reach different anatomical organs and cause pathological changes. The dental office is an appropriate place to take preventive measures for patients in both the oral and cardiovascular health fields. A current bibliographic search was carried out with the key words in PubMed, Cochrane, Google Scholar and SciELO, and this article reviews the literature on periodontitis, its relationship with cardiovascular diseases and the promotion of cardiovascular health.

Arq. bras. cardiol ; 117(3): 476-483, Sept. 2021. graf
Article in English, Portuguese | LILACS | ID: biblio-1339188


Resumo Fundamento: A doença cardiovascular é a principal causa de morte em todo o mundo. A apoptose mediada por hipóxia em cardiomiócitos é uma das principais causas de distúrbios cardiovasculares. O tratamento com a proteína do fator de crescimento endotelial vascular (VEGF, do inglês vascular endothelial growth factor) foi testado, mas as dificuldades operacionais limitaram seu uso. Entretanto, com os avanços da terapia gênica, aumentou o interesse na terapia gênica baseada no VEGF em doenças cardiovasculares. No entanto, o mecanismo preciso pelo qual a reposição de VEGF resgata os danos pós-hipóxia em cardiomiócitos não é conhecido. Objetivos: Investigar o efeito da expressão de VEGF121 pós-hipóxia utilizando cardiomiócitos de ratos neonatos. Métodos: Cardiomiócitos isolados de ratos neonatos foram utilizados para estabelecer um modelo in vitro de lesão cardíaca induzida por hipóxia. O efeito da superexpressão de VEGF, isolado ou em conjunto com inibidores de moléculas pequenas que têm como alvo os canais de cálcio, receptores sensíveis ao cálcio (CaSR, do inglês calcium-sensitive receptors) e calpaína, no crescimento e proliferação celular em lesão de cardiomiócitos induzidos por hipóxia, foram determinados com ensaio de MTT, coloração TUNEL, coloração com Anexina V/PI, lactato desidrogenase e atividade da caspase. Para análise estatística, um valor de p<0,05 foi considerado significativo. Resultados: Verificou-se que o efeito do VEGF121 foi mediado por CaSR e calpaína, mas não foi dependente dos canais de cálcio. Conclusões: Nossos resultados, mesmo em um ambiente in vitro, estabelecem as bases para uma validação futura e testes pré-clínicos da terapia gênica baseada em VEGF em doenças cardiovasculares.

Abstract Background: Cardiovascular disease is the major cause of death worldwide. Hypoxia-mediated apoptosis in cardiomyocytes is a major cause of cardiovascular disorders. Treatment with vascular endothelial growth factor (VEGF) protein has been tested but operational difficulties have limited its use. However, with the advancements of gene therapy, interest has risen in VEGF-based gene therapy in cardiovascular disorders. However, the precise mechanism by which VEGF replenishment rescues post-hypoxia damage in cardiomyocytes is not known. Objectives: To investigate the effect of post-hypoxia VEGF121 expression using neonatal rat cardiomyocytes. Methods: Cardiomyocytes isolated from neonatal rats were used to establish an in vitro model of hypoxia-induced cardiac injury. The effect of VEGF overexpression, alone or in combination with small-molecule inhibitors targeting calcium channel, calcium sensitive receptors (CaSR), and calpain on cell growth and proliferation on hypoxia-induced cardiomyocyte injury were determined using an MTT assay, TUNEL staining, Annexin V/PI staining, lactate dehydrogenase and caspase activity. For statistical analysis, a value of P<0.05 was considered to be significant. Results: The effect of VEGF121 was found to be mediated by CaSR and calpain but was not dependent on calcium channels. Conclusions: Our findings, even though using an in vitro setting, lay the foundation for future validation and pre-clinical testing of VEGF-based gene therapy in cardiovascular diseases.

Animals , Rats , Vascular Endothelial Growth Factor A/metabolism , Receptors, Calcium-Sensing/metabolism , Peptide Hydrolases/metabolism , Myocytes, Cardiac/metabolism , Hypoxia , Mitochondria
J. Hum. Growth Dev. (Impr.) ; 31(2): 291-301, May-Aug. 2021.
Article in English | LILACS, INDEXPSI | ID: biblio-1340088


INTRODUCTION: metabolic syndrome (SM) is a set of metabolic imbalances that are associated with the development of cardiovascular diseases, type 2 diabetes mellitus, in addition to other chronic non-communicable diseases. SM has been gaining prominence in the scientific community mainly due to link with the increase of the obesity epidemic in the worldOBJECTIVE: To analyze the factors associated with metabolic syndrome and its prevalence in a vulnerable population in the Northern Region of BrazilMETHODS: This is a cross-sectional study with artisanal fishers from the state of Tocantins, and data collected between 2016 and 2017 were used. The outcome variable for MS was defined according to the criteria of the International Diabetes Federation. The following variables were assessed: socioeconomic and demographic information, fish consumption, and smoking. For statistical and data analysis, the Shapiro-Wilk test, Poisson regression, Student's t-test, and interquartile regression were evaluatedRESULTS: The general prevalence rate (PR) of MS was 31.9% higher in women than in men. The factors associated with MS were economic class and smoking, and there was an association between socioeconomic class and smoking (p=0.015). The most prevalent component was abdominal obesity with a rate of 62.5% (95% confidence interval [CI]: 54.5, 70.5). The prevalence of MS in terms of sex (PR=2.27, 95% 1.04 CI, 4.92, p=0.037), smoking (PR=2.40, 95% CI, 30, p=0.003) and years of professional experience (>10 PR=2.07, 95% CI 1.06, 4.05, p=0.033) was also assessedCONCLUSION: In the present study, the prevalence of SM was associated with smoking and socioeconomic status, which is considered high when compared to the worldwide prevalence. These findings highlight the importance of looking at public policies so that health services can develop actions that generate greater adherence to good health practices by the population

INTRODUÇÃO: A síndrome metabólica (SM) é um conjunto de desequilíbrios metabólicos que estão associados ao desenvolvimento de doenças cardiovasculares, diabetes mellitus tipo 2 além de outras doenças crônicas não transmissíveis. A SM vem ganhando destaque na comunidade científica principalmente por sua ligação com o aumento da epidemia de obesidade no mundoOBJETIVO: Analisar os fatores associados à síndrome metabólica e sua prevalência em população vulnerável da Região Norte do BrasilMÉTODO: Trata-se de um estudo transversal com pescadores artesanais do estado do Tocantins, e foram utilizados dados coletados entre 2016 e 2017. A variável desfecho para SM foi definida de acordo com os critérios da International Diabetes Federation. As seguintes variáveis foram avaliadas: informações socioeconômicas e demográficas, consumo de peixe e tabagismo. Para análise estatística e de dados, foram avaliados o teste de Shapiro - Wilk, regressão de Poisson, teste t de Student e regressão interquartilRESULTADOS: A taxa geral de prevalência (RP) da SM foi 31,9% maior em mulheres do que em homens. Os fatores associados à SM foram classe econômica e tabagismo e houve associação entre classe socioeconômica e tabagismo (p = 0,015). O componente mais prevalente foi obesidade abdominal com uma taxa de 62,5% (intervalo de confiança de 95% [IC]: 54,5, 70,5). A prevalência de SM em termos de sexo (RP = 2,27, IC 95% 1,04, 4,92, p = 0,037), tabagismo (RP = 2,40, IC 95%, 30, p = 0,003) e anos de experiência profissional (> 10 RP = 2,07, IC 95% 1,06, 4,05, p = 0,033) também foi avaliadoCONCLUSÃO: No presente estudo, a prevalência de SM esteve associada ao tabagismo e ao nível socioeconômico, sendo considerada elevada quando comparada a prevalência mundial. Esses achados assinalam a importância de um olhar das políticas públicas para que os serviços de saúde possam desenvolver ações que geram maior adesão as boas práticas de saúde pela população

Humans , Male , Female , Cardiovascular Diseases , Cross-Sectional Studies , Metabolic Syndrome , Vulnerable Populations , Life Style , Obesity
Revista Pesquisa em Fisioterapia ; 11(4): 730-737, 20210802. tab
Article in English, Portuguese | LILACS-Express | LILACS | ID: biblio-1349049


| INTRODUÇÃO: As repercussões cardiorrespiratórias da cirurgia cardíaca podem ser avaliadas por teste submáximo. OBJETIVO: comparar as respostas cardiorrespiratórias do teste de sentar e levantar em um minuto (TSL1) nos indivíduos, entre o momento pré e pós de cirurgia cardíaca. MÉTODOS: Estudo de caráter transversal e analítico, incluiu 45 indivíduos de ambos os sexos, estáveis hemodinamicamente, com fração de ejeção maior que 45%, que foram submetidos à cirurgia de revascularização do miocárdio no Instituto do Coração de um Hospital do interior do estado do Rio Grande do Sul, entre 2018 e 2019. As variáveis de desfechos foram coletadas no repouso e ao final do teste, um dia antes da cirurgia e no pós-operatório: pressão arterial sistólica e diastólica (PAS e PAD em mmHg), frequência cardíaca (FC bpm), frequência respiratória (FR rpm), saturação periférica de oxigênio (SpO2 %), fadiga de membros inferiores (Fmm 0-10) e dispneia (Di 0-10), número de repetições e interrupções do teste. Foi utilizado o programa R para o tratamento dos dados, para avaliar a normalidade foi aplicado o teste de Shapiro Wilk, a comparação dos grupos pelo teste não paramétrico de Wilcoxon. RESULTADOS: A maioria do sexo masculino (71%) e média de idade foi de 61± 9 anos. No pré-operatório, ocorreu aumento entre o repouso e o final do teste, PAS, FC, FR, Fmm e Di (p<0,05). No pós-operatório, houve aumento entre o repouso e o final do teste, para FC, FR, Fmm e Di (P<0,05), contudo, sem elevação da PAS. Ao comparar as variáveis entre os momentos pré e pós, observamos maiores valores da FC, FR e número de interrupções na condição pós (p<0,05), bem como menores valores para a PAS, SpO2 e número de repetições (p<0,05) para essa condição. CONCLUSÃO: Os dados desta pesquisa comprovam que o TSL1 realizado no pré-operatório de cirurgia cardíaca, assim como entre o 4° ou 5° dia de pós-cirurgia cardíaca, é seguro e eficaz, representado pela ausência das repercussões cardiorrespiratórias que comprometessem ou agravassem o quadro clínico do paciente. O TSL1 foi capaz de induzir respostas cardiorrespiratórias fisiológicas no pré-operatório; contudo, na condição pós acarretou respostas cardiorrespiratórias mais elevadas no repouso e atenuada resposta em exercício em comparação ao pré-operatório.

INTRODUCTION: The cardiorespiratory repercussions of heart surgery can be assessed through submaximal testing. OBJECTIVE: Compare cardiorespiratory responses to the one-minute sit-and-stand test in individuals pre- and post-heart surgery. METHODS: An analytical, cross-sectional study was conducted involving 45 hemodynamically stable male and female patients with an ejection fraction greater than 45% submitted to coronary artery bypass surgery at a cardiology service of a hospital in the interior of the state of REDACTED between 2018 and 2019. The following variables were collected at rest and the end of the test one day before surgery and postoperatively: systolic and diastolic blood pressure (SBP and DBP, mmHg), heart rate (HR, bpm), respiratory rate (RR, rpm), peripheral saturation oxygen (SpO2, %), lower limb fatigue (LLF, 0-10), dyspnea (0-10), number of test repetitions and number of interruptions. The R program was used to process the data. The Shapiro-Wilk test was used for the determination of normality. The groups were compared using the non-parametric Wilcoxon test. RESULTS: Most participants were male (71%), and the mean age was 61±9 years. In the preoperative period, statistically significant increases (p≤0.05) were found for SBP, HR, RR, LLF, and dyspnea between resting values and the end of the test. Significant increases (p≤0.05) were found in the postoperative period for HR, RR, LLF, and dyspnea between rest and the end of the test, with no increase in SBP. Comparing the preoperative and postoperative evaluations variables, higher HR, RR, the number of interruptions and lower SBP, SpO2, and the number of repetitions were found after surgery (p≤0.05). CONCLUSION: The one-minute sit-to-stand test induced physiological cardiorespiratory responses in the preoperative evaluation. However, higher cardiorespiratory responses at rest and an attenuated response to exercise were found in the postoperative evaluation compared to the preoperative evaluation.

Rev. medica electron ; 43(4): 1045-1055, 2021.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1341534


RESUMEN La cardiopatía isquémica y los accidentes cerebrovasculares son la primera causa de muerte en el mundo. La enfermedad cardiovascular de origen ateroesclerótico es un problema internacional de salud, que constituye una carga social, sanitaria y económica. Se realizó un análisis de las principales guías internacionales sobre dislipoproteinemias y su manejo, como las de la Sociedad Europea de Cardiología y las del Colegio Americano de Cardiología/Asociación Americana del Corazón. También, de los principales artículos publicados en los últimos cinco años sobre el manejo de la hipercolesterolemia, de los cuales se tomaron 20 publicaciones en Medline, Google Académico y SciELO. Las mencionadas guías reúnen las recomendaciones de sus respectivas organizaciones y las combinan con nuevas. Ambas mantienen el uso de scores de riesgo y discrepan sobre la imagenología en la determinación del tratamiento, al igual que en el uso de drogas no estatinas. Se plantea que la mejor intervención para prevenir la enfermedad cardiovascular es la promoción de un estilo de vida saludable.

ABSTRACT Ischemic cardiomyopathy and cerebrovascular stroke are the first causes of death in the world. Cardiovascular disease of atherosclerotic origins is an international health problem that is also a social, sanitary and economic burden. The authors analyzed the main international guidelines on dyslipoproteinemia, like the ones from the European Society of Cardiology and the American College of Cardiology/American Heart Association. They also considered the main articles published in the last five years on the management of hypercholesterolemia and chose 20 of them available in Medline, Google Scholar and SciELO. The before-mentioned guidelines gather the recommendations of their own organizations, and combine them with new ones. They both keep using risk scores on and differ on medical imaging determining the treatment, and also in the use of non-statin drugs. It is stated that the better intervention to prevent cardiovascular disease is the promotion of a healthy lifestyle.

Int. j. cardiovasc. sci. (Impr.) ; 34(4): 393-397, July-Aug. 2021. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1286832


Abstract Background: Cardiovascular disease (CVD) comprises a group of cardiac and circulatory diseases. Despite the high incidence in males, women after menopause have an exponential increase in the risk of CVD. Objective: To identify the leading risk factors for CVD and describe quality of life and functionality in women hospitalized for cardiac causes during the climacteric period. Materials and methods: Observational descriptive study. Quality of life was assessed through the SF-36 questionnaire, and functionality through the Functional Independence Measurement (FIM) scale. Records were used to identify the main risk factors associated with CVD in climacteric women. Results: We included 30 patients (mean age, 55 ± 6 years). The mean FIM score was 118 ± 3, and the mean SF-36 score, 20 ± 10. Hypertension and sedentary lifestyle were the most prevalent cardiovascular risk factors in these women. Conclusion: Hypertension and sedentary lifestyle were the most prevalent cardiovascular risk factors in this sample of climacteric women hospitalized for cardiac causes. Quality of life was strongly affected, with social, emotional, and mental health domains showing the most impact.

Rev. cuba. endocrinol ; 32(2): e303, 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1347398


Introducción: El sexo influye en la susceptibilidad de las personas de ambos géneros con relación a la mayoría de las enfermedades comunes, incluidas la diabetes mellitus y la aterosclerosis. Objetivo: Identificar si existen diferencias en la presentación de la enfermedad cardiovascular aterosclerótica entre hombres y mujeres de edad mediana con diabetes mellitus. Métodos: Se realizó un estudio descriptivo de corte transversal en 1449 pacientes con diabetes mellitus en edad mediana (40 a 59 años) que ingresaron en el Centro de Atención al Diabético de Bayamo, Granma, desde el año 2010 al 2019. Se empleó la prueba de Chi Cuadrado para comprobar la relación entre las variables cualitativas, y T de Student para comparar los valores promedio de las variables cuantitativas. Resultados: La proporción de enfermedad cardiovascular aterosclerótica en el sexo masculino fue similar a la del femenino (51,4 por ciento x 48,6 por ciento, p=0.2328). No hubo discrepancias importantes en el porcentaje de la enfermedad, entre ambos sexos, en los diferentes grupos etarios. El riesgo de enfermedad cardiovascular aterosclerótica en los hombres fue mayor que en las mujeres premenopausicas (OR=2,19, IC: 1,4-3,3 p=0,0002), pero inferior respecto a las posmenopáusicas. (OR=1.12, IC: 0.8-1.4, p=0.4129). El análisis multivariado mostró al tiempo de la diabetes >10 años y a la hipertensión arterial como riesgo de enfermedad cardiovascular aterosclerótica en ambos sexos. Asimismo, se evidenció en la edad mayor de 45 años en los hombres (OR=2.5, IC: 1.4-4.6) y la menopausia en las mujeres (OR=1.8, IC: 1.1-3.07). Conclusiones: La frecuencia de la enfermedad cardiovascular aterosclerótica en las personas de edad mediana con diabetes mellitus es similar en ambos sexos. El sexo masculino tiene mayor riesgo de enfermarse que las mujeres premenopausicas, pero menor que las posmenopáusicas. La hipertensión arterial y el tiempo de la diabetes son factores de riesgo comunes para uno y otro sexo(AU)

Introduction: Sex influences the susceptibility of people of both genders to most common diseases, including diabetes mellitus (DM) and atherosclerosis. Objective: Identify if there are differences in the presentation of atherosclerotic cardiovascular disease between middle-aged men and women with diabetes mellitus. Methods: A descriptive cross-sectional study was conducted in 1449 patients with DM in middle age (40 to 59 years) who were admitted to the Diabetic´s Care Center of Bayamo, Granma province, from 2010 to 2019. The Chi-Square test was used to check the relation between the qualitative variables, and the T Student test to compare the average values of the quantitative variables. Results: The proportion of atherosclerotic cardiovascular disease in males was similar to that of females (51.4 percent x 48.6 percent, p=0.2328). There were no major discrepancies in the percentage of atherosclerotic cardiovascular disease, between both sexes, in the different age groups. The risk of atherosclerotic cardiovascular disease in men was higher than in pre-menopausal women (OR=2.19, CI: 1.4-3.3 p=0.0002), but lower than in post-menopausal women. (OR=1.12, CI: 0.8-1.4, p=0.4129). Multivariate analysis showed diabetes >10 years and arterial hypertension as a risk of atherosclerotic cardiovascular disease in both sexes. It was also evidenced in ages over 45 years in men (OR=2.5, CI: 1.4-4.6) and menopause in women (OR=1.8, CI: 1.1-3.07). Conclusions: The frequency of atherosclerotic cardiovascular disease in middle-aged people with diabetes mellitus is similar in both sexes. Males have a higher risk of atherosclerotic cardiovascular disease than pre-menopausal women, but lower than post-menopausal women. High blood pressure and diabetes time are common risk factors for both sexes(AU)

Humans , Male , Female , Middle Aged , Menopause , Cardiovascular Diseases/mortality , Diabetes Mellitus/etiology , Atherosclerosis/etiology , Heart Disease Risk Factors , Chi-Square Distribution , Epidemiology, Descriptive , Cross-Sectional Studies , Multivariate Analysis