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Article in English | WPRIM | ID: wpr-929036


With the recent upsurge of studies in the field of microbiology, we have learned more about the complexity of the gastrointestinal microecosystem. More than 30 genera and 1000 species of gastrointestinal microflora have been found. The structure of the normal microflora is relatively stable, and is in an interdependent and restricted dynamic equilibrium with the body. In recent years, studies have shown that there is a potential relationship between gastrointestinal microflora imbalance and gastric cancer (GC) and precancerous lesions. So, restoring the balance of gastrointestinal microflora is of great significance. Moreover, intervention in gastric premalignant condition (GPC), also known as precancerous lesion of gastric cancer (PLGC), has been the focus of current clinical studies. The holistic view of traditional Chinese medicine (TCM) is consistent with the microecology concept, and oral TCM can play a two-way regulatory role directly with the microflora in the digestive tract, restoring the homeostasis of gastrointestinal microflora to prevent canceration. However, large gaps in knowledge remain to be addressed. This review aims to provide new ideas and a reference for clinical practice.

Drugs, Chinese Herbal/therapeutic use , Gastrointestinal Microbiome , Humans , Medicine, Chinese Traditional , Precancerous Conditions/pathology , Stomach Neoplasms/pathology
Article in Chinese | WPRIM | ID: wpr-692610


Gastrointestinal microflora are the largest and the most complicated micro-ecosystem in hu-man′s body. It is parasitic on the human′s gastrointestinal tract,and help the host to finish many physiological and biochemical functions. The patients who are diagnosed with leukemia will have large change in their gastro-intestinal microflora. After allogeneic hematopoietic stem cell transplantation,patients can suffer from acute graft versus host disease,and studies have shown that gastrointestinal microflora play an important role in reducing the incidence of acute graft-versus-host disease. Maintaining the balance of gastrointestinal microflora and using it as the target for leukemia treatment can prolong the survival period of leukemia patients. This phenomenon mani-fests that the gastrointestinal microflora is closely associated with leukemia. It will provide new strategy to leuke-mia′s treatment by studying the correlation between gastrointestinal microflora and leukemia.

Article in Chinese | WPRIM | ID: wpr-459775


Metagenomics ( metagenome) obtained all the microorganisms genome in specific biological environment from DNA samples directly from soil, water and skin, body cavity of human and animals.The metagenomic library was constructed by cloning them into alternative host cells using the vector, which is a discipline of screening new active substances and new genes by high-throughput sequencing.Therefore,using metagenomics not only can effectively detect the composition of microbial community of specific environment,but also greatly expanded the utilize the space of the microbial resources, developed of the next sequencing, enriched the content of bioinformatics. Based on the advantages of metagenomics,we summarized the major advances of metagenomics in human and animal pathogenic microorganisms in recent years,which might be used for the investigation and analysis of microbial pathogens of laboratory animal, animal epidemic monitoring and diagnosis of biological safety.