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Article | IMSEAR | ID: sea-225691


Aims: To validate the monocyte monolayer assay (MMA) technique concerning its suitability for blood donor screening and its cost per test performed. The MMA is an in vitro simulation of the behavior of the antibodies, demonstrating the reactions that would occur in the endothelial reticulum system after a transfusion of incompatible red blood cells, indicating the risk of a hemolytic transfusion reaction and therefore of the clinical significance of the antibodies. Study Design: Blood samples of alloimmunized patients, selected at random from a blood donation bank, were submitted to validation tests recommended by the Brazilian National Health Surveillance Agency for the approval of new testing procedures. Place and Duration of Study: The following Brazilian institutions were involved between June 2009 and July 2010: Immunohematology laboratory of the Hematology and Hemotherapy Center of Santa Catarina state in Florianópolis, Department of Medicine (Medical Unit IV) and Department of Radiology of the Institute of Medical Sciences, Hospital Lahore in São Paulo. Methodology: Ninety samples of alloimmunized patients treated by the Santa Catarina blood donors were used. The validation tests evaluated the selectivity, linearity, precision, and accuracy of the MMA method and determined the limits of detection and quantification. External validation of the method was performed by comparing these results with those of an independent laboratory in São Paulo, while making sure that the latter was blind to the results of the former. The coefficient of variation was used to express the MMA testing precision of 5 replicates across 5 different concentration levels. Type I error for evaluating statistical significance was set at 5%. Results: Selectivity assessment of the impact of multiple alloantibodies on the MMA test result showed no statistically significant difference (P>0.05) across the titers of 64, 256, and 2048, each with three replications, thus confirming the test specificity. Homoscedasticity of the monocyte index (MI) data was not refuted by Levine's test with the F-value of 0.746, much below the value of 3.056 needed to achieve a statistical significance level of P<0.05. MI linearity against the logarithm of the alloantibody concentration was shown in a simple linear regression where the latter predicted 83% of the variation in the former, and the regression slope of 0.4 (95% confidence interval 0.32, 0.48). The limits of detection and quantification on the logarithm scale were 0.28 and 0.84, respectively. External validation found no statistically significant difference between the MMA test results from the two independent laboratories. The coefficient of variation of <15% indicated good MMA testing precision under routine laboratory conditions. Conclusion: The assay met all validation criteria and was therefore effective in assessing the clinical significance of alloantibodies.

Indian J Ophthalmol ; 2023 Jul; 71(7): 2803-2807
Article | IMSEAR | ID: sea-225132


Purpose: The objective of this study was to identify the association between fetal hemoglobin (HbF) concentration, blood transfusion, and retinopathy of prematurity (ROP) in preterm infants. Methods: This was an observational, prospective study. A total of 410 preterm infants born with <36 weeks gestational age and <2.0 kg birth weight in a tertiary care center of central India for a period of 1 year were included in this study. Clinical data were obtained from case notes. HbF of infants was measured in the blood sample using high?performance liquid chromatography at the first visit and after 1 month follow?up and was analyzed statistically. Dilated fundus examination was done as per ROP screening guidelines, and ROP was classified as per the International Classification of Retinopathy of Prematurity (ICROP), 2021. The study subjects were divided into two groups based on the status of ROP. The relationship among HbF, blood transfusion, and ROP was evaluated in both the groups. The relationship between other clinical characteristics and various neonatal risk factors was also studied between the groups. Results: A total of 410 preterm infants were included in this study, of which 110 infants had ROP (26.8%). Blood transfusion was found to be significantly associated with the development of ROP. Higher fraction of HbF (%) was associated with a lower prevalence of ROP. HbF was also inversely related with the severity of ROP. Conclusion: Replacing HbF by adult hemoglobin during blood transfusion may promote the development of ROP. Conversely, maintaining a higher percentage of HbF may be a protective factor against ROP.

Educ. med. super ; 37(1)mar. 2023. tab
Article in Spanish | LILACS-Express | LILACS, CUMED | ID: biblio-1440011


Introducción: Para una práctica transfusional segura se requiere una formación en medicina transfusional. Objetivo: Determinar la manera en que se integran los contenidos y las habilidades de medicina transfusional en la formación y la especialización médica en Cuba. Métodos: Se hizo un estudio educacional, analítico, de corte transversal en la Universidad de Ciencias Médicas de Camagüey, desde marzo de 2020 hasta julio de 2021. Se realizó un análisis documental para precisar cómo se integraban los contenidos y las habilidades de medicina transfusional al currículo para la formación de médicos, a los programas de estudio del internado vertical en 26 especialidades médicas, y a 29 planes de estudio y programas de especialización en Cuba. Resultados: El currículo para la formación de médicos en Cuba no incluye medicina transfusional. La asignatura que más contribuye a la formación en esta área del saber es Sangre y Sistema inmune. Los contenidos y las habilidades de medicina transfusional solo se incluyen expresamente en nueve programas de estudio del internado vertical y en 12 planes de estudio y programas de especialización. Conclusiones: Existe una insuficiente integración de los contenidos y las habilidades de medicina transfusional en el currículo de la carrera de medicina en Cuba, situación que se manifiesta también en los programas de estudios de los internados verticales y en la mayoría de los programas de las especialidades médicas.

Introduction: Safe transfusion practice requires training in transfusion medicine. Objective: To determine the way in which transfusion medicine contents and skills are integrated into medical training and specialization in Cuba. Methods: An educational, analytical and cross-sectional study was carried out at Universidad de Ciencias Médicas de Camagüey, from March 2020 to July 2021. A documentary analysis was conducted to determine how transfusion medicine contents and skills were integrated into the curriculum for the training of physicians, into the study programs of the vertical internship in 26 medical specialties, as well as into 29 study plans and specialization programs in Cuba. Results: The curriculum for the training of physicians in Cuba does not include transfusion medicine. The subject that most contributes to training in this area of knowledge is Blood and Immune System. Transfusion medicine contents and skills are only expressly included in nine vertical internship study programs and in twelve study plans and specialization programs. Conclusions: There is insufficient integration of transfusion medicine contents and skills in the Cuban medical major curriculum, a situation that is also manifested in the study programs of vertical internships and in most of the medical specialties programs.

Humans , Curriculum , Professional Training , Cross-Sectional Studies , Education, Medical , Education, Medical, Graduate , Health Postgraduate Programs , Medicine
Indian Heart J ; 2023 Feb; 75(1): 59-67
Article | IMSEAR | ID: sea-220960


Objective: A recently published randomized control trial showed different results with suture-based vascular closure device (VCD) than plug-based VCD in patients undergoing transfemoral transcatheter aortic valve replacement (TAVR). The learning curve for MANTA device is steep, while the learning curve for suture based VCD is shallow as the devices are quite different. In this meta-analysis, we have compared suture-based (ProGlide and Prostar XL) vs plug-based VCDs (MANTA). Methods: We performed a meta-analysis of all published studies (using PubMed/Medline and Cochrane databases) reporting the clinical outcome of plug-based vs suture-based VCDs in transfemoral TAVR patients. Results: We included nine studies with a total of 2865 patients (plug-based n ¼ 1631, suture-based n ¼ 1234). There was no significant difference in primary outcome of all bleeding when using plugbased as opposed to suture-based VCDs (RR 1.14 [0.62e2.06] I2 ¼ 72%). There was no significant difference in the incidence of secondary outcomes between two groups including major life threatening bleeding (RR 1.16 [0.38e3.58] I2 ¼ 65%), major vascular complications (RR 0.84 [0.35e2.00] I2 ¼ 55%), minor vascular complications (RR 1.05 [0.56e1.95] I2 ¼ 42%), pseudo aneurysm (RR 1.84 [0.11e29.98] I 2 ¼ 44%), stenosis-dissection (RR 0.98 [0.66e1.47] I2 ¼ 0%), VCD failure (RR 1.71 [0.96e3.04] I2 ¼ 0%), and blood transfusion (RR 1.01 [0.38e2.71], I2 ¼ 61%). Conclusion: Large bore arteriotomy closure with plug-based VCD was not superior to suture-based VCDs in this transfemoral TAVR population. There was very frequent use of secondary VCDs in suture-based VCD group which is not practical when using MANTA. Additional high-powered studies are required to determine the safety and efficacy of MANTA device.

Bol. méd. Hosp. Infant. Méx ; 80(1): 46-52, Jan.-Feb. 2023. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1429939


Abstract Background: The efficiency of blood products (BP) requisition in elective non-cardiac surgeries is inherently complex. Moreover, it is aggravated in the pediatric population. This study aimed to identify the factors associated with using less than the requested BP during the transoperative period in pediatric patients undergoing elective non-cardiac surgery. Methods: We conducted a cross-sectional comparative study including 320 patients undergoing elective non-cardiac surgery for whom BPs were requested. Low requirements were considered when less than 50% of the requested amount or no BPs were used, and high requirements when more than the requested amount was used. The Mann-Whitney's U test was applied for comparative analysis, and multiple logistic regression was used to adjust for factors associated with lower requirements. Results: The median age of the patients was 3 years. From 320 patients, 68.1% (n = 218) received less than the requested amount of BP, while only 1.25% (n = 4) received more than the requested amount of BP. Factors associated with transfusion of less than the requested BPs were prolonged clotting time (odds ratio (OR) = 2.66) and anemia (OR = 0.43). Conclusions: Factors associated with lower than requested BP transfusion were prolonged clotting time and anemia.

Resumen Introducción: La eficiencia de la solicitud de productos sanguíneos (PS) en las cirugías electivas no cardiacas es, de por sí, compleja. No obstante, se agrava para la población pediátrica. El objetivo de este estudio fue identificar los factores asociados con la utilización de una cantidad de PS menor a la solicitada durante el transoperatorio en pacientes pediátricos sometidos a cirugía electiva no cardiaca. Métodos: Se realizó un estudio transversal comparativo donde se incluyeron 320 pacientes sometidos a cirugía electiva no cardiaca para quienes se solicitaron PS. Los requerimientos de hemoderivados se consideraron como menores cuando no se utilizaron o se utilizó menos del 50% de lo solicitado y como mayores cuando se utilizó una cantidad mayor a la solicitada. Se aplicó la prueba U de Mann-Whitney para el análisis comparativo y regresión logística múltiple para ajustar los factores asociados a la presencia de menores requerimientos. Resultados: La mediana para la edad de los pacientes fue de 3 años. Se transfundió una cantidad de PS menor a la solicitada en el 68.1% (n = 218) de los pacientes, mientras que se transfundió una cantidad mayor a la solicitada solo en el 1.25% de los pacientes (n = 4). Los factores asociados con la transfusión de una cantidad de PS menor a la solicitada fueron tiempos de coagulación alargados (TCA) (razón de momios (RM) = 2.66) y anemia (RM = 0.43). Conclusiones: Los factores asociados a una transfusión de PS inferior a la solicitada fueron el tiempo de coagulación prolongado y la anemia.

Article | IMSEAR | ID: sea-217095


Introduction: Turnaround time (TAT) is one of the most crucial performance indicators for blood transfusion and laboratory services. It is especially crucial in transfusion services due to its seminal role as a determining factor in patient care outcomes. We examined our institution’s TAT for issuing blood units. Materials and Methods: The Department of Immunohematology and Blood Transfusion, MGM Medical College and Hospital in Navi Mumbai, Maharashtra, India, undertook this retrospective noninterventional study over 12 months from January 01, 2020 to December 31, 2020. TAT was determined using a random audit of 10% of all monthly requests at the blood center. All requests for packed red cells (PRCs) received in the blood center during the study period were included in the evaluation. All requests for other blood components such as fresh-frozen plasma, random donor platelets, and cryoprecipitates were excluded along with all reservations for PRCs. A team of investigators tracked 369 requests for packed red cells over the year, noting the turnaround time. The standard TAT was set depending on the nature of the clinical case. Any significant deviation from institutionally established TAT was investigated, and root cause analysis was done. Results: The majority of transfusion requests were routine (72%) followed by emergency (23%) and lifesaving (5%). For routine cases, the average TAT was observed at 104 minutes. For emergency cases, the average TAT was observed at 39 minutes. For lifesaving cases, the average TAT was observed at 12 minutes. The highest number of cases were categorized under routine, followed by emergency cases and lifesaving categories. Conclusion: It was observed that there were no significant variations in turnaround time in routine, emergency, or lifesaving cases. Overall, as per our blood center standards, TAT for the issue of packed red cells was observed to fall under the normal range for routine, emergency, and lifesaving. Any outliers observed during the duration of the study were mainly due to inadequate samples or patient details received at the blood center or the presence of irregular antibodies encountered during the crossmatch.

Arq. gastroenterol ; 60(1): 137-143, Jan.-Mar. 2023.
Article in English | LILACS-Express | LILACS | ID: biblio-1439395


ABSTRACT Background: The use of autologous blood transfusion in digestive tract surgeries, whether after preoperative blood collection or intraoperative blood salvage, is an alternative to allogeneic blood, which brings with it certain risks and shortage, due to the lack of donors. Studies have shown lower mortality and longer survival associated with autologous blood, however the theoretical possibility of spreading metastatic disease is still one of the limiting factors of its use. Objective: To evaluate the application of autologous transfusion in digestive tract surgeries, noting the benefits, damages and effects on the spread of metastatic disease. Methods: This is an integrative review of the literature available in the PubMed, Virtual Health Library and SciELO databases, by searching for "Autologous Blood Transfusion AND Gastrointestinal Surgical Procedures". Observational and experimental studies and guidelines published in the last five years in Portuguese, English or Spanish were included. Results: Not all patients benefit from blood collection before elective procedures, with the time of surgery and hemoglobin levels some of the factors that may indicate the need for preoperative storage. Regarding the intraoperative salvaged blood, it was observed that there is no increased risk of tumor recurrence, but the importance of using leukocyte filters and blood irradiation is highlighted. There was no consensus among the studies whether there is a maintenance or reduction of complication rates compared to allogeneic blood. The cost related to the use of autologous blood may be higher, and the less stringent selection criteria prevent it from being added to the general donation pool. Conclusion: There were no objective and concordant answers among the studies, but the strong evidence of less recurrence of digestive tumors, the possibility of changes in morbidity and mortality, and the reduction of costs with patients suggest that the practice of autologous blood transfusion should be encouraged in digestive tract surgeries. It is necessary to note if the deleterious effects would stand out amidst the possible benefits to the patient and to health care systems.

RESUMO Contexto: O emprego da transfusão sanguínea autóloga nas cirurgias do aparelho digestivo, seja através da coleta de sangue no pré-operatório ou da recuperação de sangue no intraoperatório, é uma alternativa ao sangue alogênico, que traz consigo determinados riscos e a escassez, pela falta de doadores. Estudos têm demonstrado menor mortalidade e maior sobrevida associadas ao sangue autólogo, no entanto a possibilidade teórica de propagação de doença metastática ainda é um dos fatores limitantes do seu uso. Objetivo: Avaliar a aplicação da transfusão autóloga em cirurgias do aparelho digestivo, observando os benefícios, prejuízos e efeitos sobre a propagação de doenças metastáticas. Métodos: Trata-se de uma revisão integrativa da literatura disponível nas bases de dados PubMed, Biblioteca Virtual em Saúde e SciELO, através da busca por "Autologous Blood Transfusion AND Gastrointestinal Surgical Procedures". Foram incluídos estudos observacionais e experimentais e guidelines publicados nos últimos 5 anos, nos idiomas português, inglês ou espanhol. Resultados: Nem todos os pacientes beneficiam-se da coleta de sangue antes de procedimentos eletivos, sendo o tempo de cirurgia e os níveis de hemoglobina alguns dos fatores que podem indicar a necessidade do armazenamento pré-operatório. Em relação ao sangue recuperado no intraoperatório, observou-se que não há maior risco de recorrência de tumores, mas destaca-se a importância do uso de filtros leucocitários e irradiação sanguínea. Não houve consenso entre os estudos se há uma manutenção ou redução das taxas de complicação, em comparação com o sangue alogênico. O custo relacionado ao uso de sangue autólogo pode ser maior, além de os critérios de seleção menos rigorosos impedirem que seja adicionado ao pool geral de doações. Conclusão: Não houve respostas objetivas e concordantes entre os estudos, mas os fortes indícios da menor recorrência de tumores digestivos, a possibilidade de alterações na morbimortalidade e a redução dos custos com os pacientes sugerem que a prática da transfusão sanguínea autóloga seja fomentada nas cirurgias do aparelho digestivo. É necessário observar se os efeitos deletérios se destacariam em meio aos possíveis benefícios ao paciente e aos sistemas de saúde.

Rev. enferm. UFSM ; 13: 17, 2023.
Article in English, Spanish, Portuguese | LILACS, BDENF | ID: biblio-1428832


Objetivo: identificar os indicadores relacionados ao processo transfusional. Método: revisão integrativa de literatura realizada entre março e maio de 2022, em nove fontes de informação no período de 2001 a 2021. Como estratégia de busca, utilizaram-se os descritores "Indicadores de Qualidade em Assistência à Saúde", "Indicadores de Serviços", "Indicadores Básicos de Saúde", "Serviço de Hemoterapia", "Transfusão de Sangue", "Segurança do Sangue", com os operadores boleanos "AND" e "OR" em três idiomas, sendo analisados 49 artigos. Resultados: foram identificados 53 indicadores, os quais se agruparam para: gestão do estoque de hemocomponentes, de produção do processo transfusional, para avaliação do processo transfusional e de suporte do processo transfusional. Conclusão: os indicadores identificados possibilitam avaliação do processo transfusional, apesar de atividades, como a avaliação do cuidado, apresentarem poucos indicadores, evidenciando a necessidade de estudos sobre a temática e construção de novos indicadores para dar sustentação à avaliação mais aprimorada do processo transfusional.

Objective: to identify transfusion-related indicators. Method: an integrative literature review carried out between March and May 2022, in nine sources of information from 2001 to 2021. As a search strategy, the descriptors "Quality Indicators in Health Care", "Service Indicators", "Basic Health Indicators", "Hemotherapy Service", "Blood Transfusion", "Blood Safety" were used, with Boolean operators "AND" and "OR" in three languages, with 49 articles being analyzed. Results: a total of 53 indicators were identified, which were grouped for: blood component stock management, transfusion process production, transfusion process assessment and transfusion process support. Conclusion: the identified indicators make it possible to assess the transfusion process, although activities, such as care assessment, present few indicators, highlighting the need for studies on the subject and the construction of new indicators to support a more improved transfusion process assessment.

Objetivo: identificar indicadores relacionados con el proceso de transfusión. Método: revisión integrativa de la literatura, realizada entre marzo y mayo de 2022, en nueve fuentes de información de 2001 a 2021. Como estrategia de busca, se utilizaron los descriptores "Indicadores de Calidad en la Atención de Salud", "Indicadores de Servicio", "Indicadores Básicos de Salud", "Servicio de Hemoterapia", "Transfusión de Sangre", "Seguridad de la Sangre", con operadores booleanos "AND" y "OR" en tres idiomas, analizando 49 artículos. Resultados: se identificaron 53 indicadores, los cuales fueron agrupados en: gestión del stock de hemocomponentes, producción del proceso transfusional, evaluación del proceso transfusional y apoyo al proceso transfusional. Conclusión: los indicadores identificados posibilitan la evaluación del proceso transfusional, aunque actividades, como la evaluación del cuidado, presenten pocos indicadores, destacando la necesidad de estudios sobre el tema y la construcción de nuevos indicadores que apoyen una evaluación más perfeccionada del proceso de transfusión.

Humans , Blood Transfusion , Indicators of Health Services , Quality Indicators, Health Care , Hemotherapy Service , Blood Safety
Rev. bras. cir. cardiovasc ; 38(3): 389-397, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1441202


ABSTRACT Introduction: Postoperative thrombocytopenia is common in cardiac surgery with cardiopulmonary bypass, and its risk factors are unclear. Methods: This retrospective study enrolled 3,175 adult patients undergoing valve surgeries with cardiopulmonary bypass from January 1, 2017 to December 30, 2018 in our institute. Postoperative thrombocytopenia was defined as the first postoperative platelet count below the 10th quantile in all the enrolled patients. Outcomes between patients with and without postoperative thrombocytopenia were compared. The primary outcome was in-hospital mortality. Risk factors of postoperative thrombocytopenia were assessed by logistic regression analysis. Results: The 10th quantile of all enrolled patients (75×109/L) was defined as the threshold for postoperative thrombocytopenia. In-hospital mortality was comparable between thrombocytopenia and non-thrombocytopenia groups (0.9% vs. 0.6%, P=0.434). Patients in the thrombocytopenia group had higher rate of postoperative blood transfusion (5.9% vs. 3.2%, P=0.014), more chest drainage volume (735 [550-1080] vs. 560 [430-730] ml, P<0.001), and higher incidence of acute kidney injury (12.3% vs. 4.2%, P<0.001). Age > 60 years (odds ratio [OR] 2.25, 95% confidence interval [CI] 1.345-3.765, P=0.002], preoperative thrombocytopenia (OR 18.671, 95% CI 13.649-25.542, P<0.001), and cardiopulmonary bypass time (OR 1.088, 95% CI 1.059-1.117, P<0.001) were positively independently associated with postoperative thrombocytopenia. Body surface area (BSA) (OR 0.247, 95% CI 0.114-0.538, P<0.001) and isolated mitral valve surgery (OR 0.475, 95% CI 0.294-0.77) were negatively independently associated with postoperative thrombocytopenia. Conclusion: Positive predictors for thrombocytopenia after valve surgery included age > 60 years, small BSA, preoperative thrombocytopenia, and cardiopulmonary bypass time. BSA and isolated mitral valve surgery were negative predictors.

Rev. bras. cir. cardiovasc ; 38(2): 227-234, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1431500


ABSTRACT Introduction: Transfusion of red blood cells is recurrent in cardiac surgery despite the well-established deleterious effects. Identifying patients with higher chances of requiring blood transfusion is essential to apply strategic preventive measures to reduce such chances, considering the restricted availability of this product. The most used risk scores to predict blood transfusion are the Transfusion Risk and Clinical Knowledge (TRACK) and Transfusion Risk Understanding Scoring Tool (TRUST). However, these scores were not validated for the Brazilian population. The objective of this study was to assess the accuracy of TRACK and TRUST scores in estimating the need for postoperative transfusion of red blood cell concentrates (TRBCC) after cardiac surgery. Methods: A clinical retrospective study was conducted using the database of a Brazilian reference service composed of patients operated between November 2019 and September 2021. Scores were compared using Mann-Whitney U test. Hosmer-Lemeshow goodness of fit test assessed calibration of the scores. Accuracy was assessed using the area under the receiver operating characteristic curve (AUC). All analyses considered a level of significance of 5%. The study was approved by the research ethics committee (CAAE 55577421.4.0000.5201). Results: This study assessed 498 patients. Only the TRACK score presented good calibration (P=0.238; TRUST P=0.034). AUC of TRACK was 0.678 (95% confidence interval 0.63 to 0.73; P<0.001), showing a significant accuracy. Conclusion: Between the scores analyzed, only the TRACK score showed a good calibration, but low accuracy, to predict postoperative TRBCC after cardiac surgery.

Arq. ciências saúde UNIPAR ; 27(6): 2718-2731, 2023.
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1436669


A transfusão de sangue é considerada uma tecnologia de grande importância na terapia moderna. Quando usada corretamente, pode salvar vidas e melhorar o quadro clínico dos pacientes. Todavia, esse procedimento pode apresentar riscos tanto aguda quanto tardia. Para tanto, o conhecimento da enfermagem é de grande relevância a fim de evitar complicações e fornecer um procedimento assertivo ao paciente. Objetivo: Demonstrar, a partir de uma revisão integrativa dos últimos quatro anos, a atribuição do enfermeiro no processo de hemotransfusão, descrevendo seu papel desde o acolhimento até a infusão dos hemoderivados. Métodos: Trata-se de uma revisão integrativa da literatura. Resultados e discussão: Para a seleção, 10 artigos científicos foram inclusos na revisão. As análises em nível de grupo mostraram que é de suma importância do conhecimento técnico e científico para a segurança do paciente. Considerações finais: O processo de hemotransfusão é de responsabilidade da enfermagem, incluindo cuidados minuciosos e atenção clínica por parte do enfermeiro, devendo ser amplamente divulgado e discutido para garantir atualização de conhecimento entre os profissionais que atuam em hemoterapia, para que possam realizar as práticas com segurança e prevenir a ocorrência de eventos adversos.

Blood transfusion is considered a technology of great importance in modern therapy. When used correctly, it can save lives and improve the condition of patients. However, this procedure may present both acute and late requirements. Therefore, nursing knowledge is of great encouragement in order to avoid complications and provide an assertive procedure to the patient. Objective: To demonstrate, based on an integrative review of the last four years, the attribution of nurses in the blood transfusion process, describing their role from reception to the infusion of blood products. Methods: This is an integrative literature review. Results and discussion: For the selection, 10 scientific articles were included in the review. The group-level analyzes appreciated that technical and scientific knowledge is of paramount importance for patient safety. Final considerations: The blood transfusion process is the responsibility of nursing, including meticulous care and clinical attention by the nurse, and should be widely publicized and discussed to ensure updating of knowledge among professionals who perform hemotherapy, so that they can carry out the practices safely and preventing the occurrence of adverse events.

La transfusión de sangre se considera una tecnología de gran importancia en la terapia moderna. Cuando se utiliza correctamente, puede salvar vidas y mejorar el estado de los pacientes. Sin embargo, este procedimiento puede presentar requisitos agudos y tardíos. Por lo tanto, los conocimientos de enfermería son de gran estímulo para evitar complicaciones y proporcionar un procedimiento asertivo al paciente. Objetivo: Demostrar, a partir de una revisión integradora de los últimos cuatro años, la atribución de enfermería en el proceso de transfusión sanguínea, describiendo su papel desde la recepción hasta la infusión de hemoderivados. Métodos: Se trata de una revisión bibliográfica integradora. Resultados y discusión: Para la selección se incluyeron en la revisión 10 artículos científicos. Los análisis a nivel de grupo apreciaron que el conocimiento técnico y científico es de suma importancia para la seguridad del paciente. Consideraciones finales: El proceso de transfusión sanguínea es responsabilidad de enfermería, incluyendo el cuidado meticuloso y la atención clínica por parte de la enfermera, y debe ser ampliamente divulgado y discutido para garantizar la actualización de conocimientos entre los profesionales que realizan hemoterapia, para que puedan llevar a cabo las prácticas con seguridad y previniendo la ocurrencia de eventos adversos. PALABRAS CLAVE: Hemoterapia; Transfusión Sanguínea; Infusión de Hemoderivados; Cuidados de Enfermería; Asignación de Enfermería.

Hematol., Transfus. Cell Ther. (Impr.) ; 45(2): 165-169, Apr.-June 2023. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1448338


Abstract Introduction In the current scenario, in which evidence-based medicine is almost obligatory, therapeutic approaches are increasingly being restricted to measures that are proven to bring benefits to the patient. Transfusion therapy follows the same concept. Even though it can be an essential support procedure in some situations, it must be carefully used, exclusively in situations in which the literature assures scientific support for its usage. Transfusion exposes patients to risks and complications, so it is necessary that we, as doctors, continue working to reduce possible mistakes involving the practice of this type of therapy. Objective To analyze if the red blood cell requests are properly made, analyzing the indication written on them (by the doctor, comparing them to the references in the actual literature. Method In this research, we have analyzed and reviewed the requests for red blood cell concentrates between August and September of 2018 received at the Hematology and Hemotherapy Center studied to find the most common mistakes made by requesters/doctors. Results A total of 397 of the 754 analyzed requests were evaluated as inadequate. Therefore, 1 out of every 2 transfusions performed did not have their requests properly completed in the city of Cascavel, Paraná. Conclusions The number of inappropriate requests was high during the studied period, especially when compared to studies available in the literature. The number of inadequacies suggests that the blood component requests and the subsequent evaluation by the transfusion agency needs to be better addressed in clinical practice.

Texto & contexto enferm ; 32: e20220234, 2023. tab
Article in English | LILACS-Express | LILACS, BDENF | ID: biblio-1450582


ABSTRACT Objective: to analyze pediatric patient safety in the administration of blood components. Method: a documentary and retrospective study, developed at a hospital in the Brazilian Midwest region. Data collection took place through medical records and 234 transfusions were identified, performed in 90 patients aged from zero to twelve years old, hospitalized between July and December 2020. An instrument based on good practice guidelines about blood components was used. Descriptive and inferential statistics were used for data analysis. Results: the transfusions were predominantly performed in breastfeeding infants (71.1%). Blood transfusions in critical sectors stood out (86.3%), as well as with indication of a clinical order (87.2%) and prescription of packed red blood cells (75.3%). The Nursing reports identified adverse events (n=05) and incidents (n=13) that were associated with inadequacies between the prescribed and infused volumes and the request and administration time (p<0.001), although no notification was formalized in the institution during the period. Conclusion: the administration of blood components presented nonconformities, which results in risk situations for pediatric patients.

RESUMEN Objetivo: analizar la seguridad de pacientes pediátricos al administrar hemocomponentes. Método: estudio documental y retrospectivo, desarrollado en un hospital de la región Centro-Oeste de Brasil. Los datos se recolectaron a través de historias clínicas y se identificaron 234 transfusiones, realizadas en 90 pacientes de cero a doce años de edad, internados entre los meses de julio y diciembre de 2020. Se empleó un instrumento basado en directrices de buenas prácticas de hemocomponentes. Para el análisis se utilizó estadística descriptiva e inferencial. Resultados: las transfusiones se realizaron predominantemente en lactantes (71,1%). Hubo predominio de transfusiones sanguíneas en sectores críticos (86,3%), con indicación de orden clínico (87,2%) y prescripción de concentrado de glóbulos rojos (75,3%). En los informes de Enfermería se identificaron eventos adversos (n=05) e incidentes (n=13) que estuvieron asociados a inconsistencias entre los volúmenes prescripto e infundido y al tiempo de solicitud y administración (p<0,001), aunque no se formalizó ninguna notificación en la institución durante el período investigado. Conclusión: la administración de hemocomponentes presentó inconformidades, lo que deriva en situaciones de riesgo para los pacientes pediátricos.

RESUMO Objetivo: Analisar a segurança do paciente pediátrico na administração de hemocomponentes. Método: Estudo documental, retrospectivo, desenvolvido em um hospital da região Centro-Oeste do Brasil. A coleta de dados ocorreu através de prontuários e foram identificadas 234 transfusões, realizadas em 90 pacientes de zero a doze anos, internados entre os meses de julho a dezembro de 2020. Utilizou-se instrumento baseado em diretrizes de boas práticas de hemocomponentes. Para a análise foi utilizada estatística descritiva e inferencial. Resultados: As transfusões ocorreram predominantemente em lactentes (71,1%). Sobressaíram hemotransfusões em setores críticos (86,3%), com indicação de ordem clínica (87,2%) e a prescrição de concentrado de hemácias (75,3%). Identificou-se no relatório de enfermagem eventos adversos (n=05) e incidentes (n=13) que se associaram a inadequações entre volume prescrito e infundido e ao tempo de solicitação e administração (p<0,001), embora nenhuma notificação foi formalizada na instituição durante o período. Conclusão: A administração de hemocomponentes apresentou inconformidades, o que resulta em situações de risco ao paciente pediátrico.

Article in English, Portuguese | LILACS, BDENF | ID: biblio-1444757


Objetivo: identificar as principais complicações ocasionadas pela transfusão sanguínea à saúde do idoso hospitalizado através da análise das evidências científicas. Método: revisão integrativa realizada com estudos em inglês provenientes de bases de dados nacionais e internacionais publicados no período de 2017 a 2021. Os principais descritores foram "Blood Transfusion", "Transfusion Reaction", "Aged" e "Hospitalization", combinados por meio dos operadores booleanos "AND" e "OR". Resultados: foram incluídos 23 estudos que retratavam as principais complicações da transfusão sanguínea para a pessoa idosa hospitalizada. As doze diferentes complicações foram alocadas em duas categorias: relacionadas a cirurgias ou complicações não-cirúrgicas. Maior tempo de permanência hospitalar, mortalidade, reações transfusionais, lesão renal aguda pós-operatória e delirium pós-operatório fizeram parte dos principais achados. Conclusão: os mecanismos pelos quais as complicações se desenvolvem ainda não estão totalmente esclarecidos, evidenciando a importância do estímulo à realização de novas pesquisas que envolvam esta temática.

Objective: to identify the main complications caused by blood transfusion to the health of the hospitalized elderly through the analysis of scientific evidence. Method: integrative review conducted with studies in English from national and international databases published in the period from 2017 to 2021. The main descriptors were "BloodTransfusion", "Transfusion Reaction", "Aged" and "Hospitalization", combined by means of the Boolean operators "AND" and "OR". Results: 23 studies were included that depicted the main complications of blood transfusion for the hospitalized elderly person. The twelve different complications were allocated into two categories: surgery-related or non-surgical complications. Longer hospital stay, mortality, transfusion reactions, postoperative acute kidney injury and postoperative delirium were among the mainachievements. Conclusion: the mechanisms by which complications develop are not yet fully understood, highlighting the importance of encouraging further research on this topic.

Objetivo: identificar las principales complicaciones ocasionadas por la transfusión sanguínea a la salud del idoso hospitalizado a través del análisis de las evidencias científicas. Método: revisión integradora realizada con estudios en inglés de bases de datos nacionales e internacionales publicados en el período 2017 a 2021. Los descriptores principales fueron "BloodTransfusion", "Transfusion Reaction", "Aged" y "Hospitalization", combinados mediante los operadores booleanos "AND" y "OR". Resultados:se incluyeron 23 estudios que retrataban las principales complicaciones de la transfusión sanguínea en el anciano hospitalizado. Las doce complicaciones diferentes se asignaron a dos categorías: complicaciones relacionadas con la cirugía o complicaciones no relacionadas con la cirugía. La prolongación de la estancia hospitalaria, la mortalidad, las reacciones transfusionales, la lesión renal aguda postoperatoria y el delirio postoperatorio formaron parte de las principales. Conclusión: los mecanismos por los que se desarrollan las complicaciones aún no se comprenden del todo, lo que pone de relieve la importancia de fomentar la investigación sobre este tema.

Humans , Male , Female , Aged , Aged, 80 and over , Blood Transfusion/statistics & numerical data , Health of the Elderly
Acta Paul. Enferm. (Online) ; 36: eAPE02021, 2023. tab
Article in Portuguese | LILACS-Express | LILACS, BDENF | ID: biblio-1419835


Resumo Objetivo Analisar o perfil dos incidentes transfusionais imediatos notificados em crianças e adolescentes internados em hospital geral de alta complexidade. Métodos Estudo documental retrospectivo, com análise de 287 Fichas de Notificação, reportando reações transfusionais em crianças e adolescentes de zero a 18 anos de idade, ocorridas no período de janeiro de 2007 e maio de 2021, em um serviço de hemovigilância de um Hospital Universitário, de caráter filantrópico, de alta complexidade, localizado na cidade de São Paulo. Resultados Das 287 fichas avaliadas, 42,5% das reações foram observadas em adolescentes (entre 12 e 18 anos), 83,6% ocorreram na primeira transfusão. Manifestações clínicas mais comuns foram lesões de pele e hipertermia. Cerca de 50% das reações ocorreram em pacientes com leucemia ou anemias e o hemocomponente associado foi o concentrado de hemácias. Incidentes mais comuns foram: reação febril não hemolítica e reações alérgicas, em sua maioria leves e moderadas. Outras reações foram 9,8% moderadas/graves. Conclusão O estudo favoreceu maior conhecimento sobre os incidentes transfusionais ocorridos em crianças e adolescentes e traz contribuições para reforçar a segurança do paciente e dos serviços de hemoterapia pediátrica.

Resumen Objetivo Analizar el perfil de las reacciones transfusionales inmediatas notificadas en niños y adolescentes internados en un hospital de alta complejidad. Métodos Estudio documental retrospectivo, con análisis de 287 Fichas de Notificación, donde se reportaron reacciones transfusionales en niños y adolescentes de cero a 18 años, ocurridas en el período de enero de 2007 a mayo de 2021, en un servicio de hemovigilancia de un hospital universitario de carácter filantrópico, de alta complejidad, ubicado en la ciudad de São Paulo. Resultados De las 287 fichas analizadas, el 42,5 % de las reacciones fue observada en adolescentes (entre 12 y 18 años) y el 83,6 % sucedió en la primera transfusión. Las manifestaciones clínicas más comunes fueron lesiones en la piel e hipertermia. Cerca del 50 % de las reacciones ocurrió en pacientes con leucemia o anemia, y el componente sanguíneo asociado fue el concentrado de eritrocitos. Los incidentes más comunes fueron: reacción febril no hemolítica y reacciones alérgicas, en su mayoría leves y moderadas. Otras reacciones fueron 9,8 % moderadas/graves. Conclusión El estudio ayudó a tener mayores conocimientos sobre los incidentes transfusionales ocurridos en niños y adolescentes y contribuye para reforzar la seguridad del paciente y de los servicios de hemoterapia pediátrica.

Abstract Objective To analyze the profile of immediate transfusion incidents reported in children and adolescents hospitalized in a high complexity general hospital. Methods This is a documentary and retrospective study that analyzed 287 notification records, reporting transfusion reactions in children and adolescents from zero to 18 years of age, occurred from January 2007 to May 2021, in a hemovigilance service of a high-complexity philanthropic university hospital in the city of São Paulo. Results Of the 287 records assessed, 42.5% of reactions were observed in adolescents (between 12 and 18 years), and 83.6% occurred in the first transfusion. Most common clinical manifestations were skin lesions and hyperthermia. About 50% of reactions occurred in patients with leukemia or anemia and the associated blood component was red blood cell concentrate. Most common incidents were nonhemolytic febrile reaction and mostly mild and moderate allergic reactions. Other reactions were 9.8% moderate/severe. Conclusion The study favored greater knowledge about transfusion incidents in children and adolescents and brings contributions to enhance patient safety and pediatric hemotherapy services.

Rev. bras. ginecol. obstet ; 44(12): 1090-1093, Dec. 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1431608


Abstract Objective To describe the clinical results of patients admitted and managed as cases of placenta accreta spectrum (PAS) at a Central American public hospital and the influence of the prenatal diagnosis on the condition. Materials and Methods A retrospective analysis of PAS patients treated at Hospital Bertha Calderón Roque, in Managua, Nicaragua, between June 2017 and September 2021. The diagnostic criteria used were those of the International Federation of Gynecology and Obstetrics (Fédération Internationale de Gynécologie et d'Obstétrique, FIGO, in French). The population was divided into patients with a prenatal ultrasonographic diagnosis of PAS (group 1) and those whose the diagnosis of PAS was established at the time of the caesarean section (group 2). Results During the search, we found 103 cases with a histological and/or clinical diagnosis of PAS; groups 1 and 2 were composed of 51 and 52 patients respectively. Regarding the clinical results of both groups, the patients in group 1 presented a lower frequency of transfusions (56.9% versus 96.1% in group 2), use of a lower number of red blood cell units (RBCUs) among those undergoing transfusions (median: 1; interquartile range: [IQR]: 0-4 versus median: 3; [IQR]: 2-4] in group 2), and lower frequency of 4 or more RBCU transfusions (29.4% versus 46.1% in group 2). Group 1 also exhibited a non-significant trend toward a lower volume of blood loss (1,000 mL [IQR]: 750-2,000 mL versus 1,500 mL [IQR]: 1,200-1,800 mL in group 2), and lower requirement of pelvic packing (1.9% versus 7.7% in group 2). Conclusion Establishing a prenatal diagnosis of PAS is related to a lower frequency of transfusions. We observed a high frequency of prenatal diagnostic failures of PAS. It is a priority to improve prenatal detection of this disease.

Rev. enferm. UERJ ; 30: e65063, jan. -dez. 2022.
Article in English, Portuguese | LILACS-Express | LILACS | ID: biblio-1392591


Objetivo: mapear os estudos que abordam a não transfusão de sangue e hemocomponentes ao paciente Testemunha de Jeová. Método: revisão de escopo, seguindo o método proposto pelo Instituto Joanna Briggs. Foram realizadas buscas em doze bases de dados nacionais e internacionais, em outubro de 2020. Não foi utilizado recorte temporal. Resultados: dos 1435 artigos encontrados nas bases de dados pesquisadas, 21 foram incluídos neste estudo, seus conteúdos foram sintetizados em três categorias: 1) Estratégias alternativas ao uso de hemocomponentes; 2) Abordagem jurídica na recusa do paciente Testemunha de Jeová; 3) Abordagem bioética na recusa do paciente Testemunha de Jeová. Conclusão: a presente revisão de escopo permitiu mapear a literatura e conhecer as inquietações e as estratégias usadas na assistência ao paciente TJ que por questões religiosas recusa transfusão de sangue e hemocomponentes. A compreensão dessas alternativas será fundamental para a garantia de uma assistência segura e na preservação da autonomia do indivíduo.

Objective: to map studies that address non-transfusion of blood and blood components to Jehovah's Witness patients. Method: this scoping review used the method proposed by the Joanna Briggs Institute. Twelve Brazilian and international databases were searched in October 2020. No time frame was used. Results: of the 1435 articles found in the databases searched, 21 were included in this study. Their contents were summarized into three categories: 1) strategies alternative to the use of blood components; 2) legal approaches to refusal by Jehovah's Witness patients; and 3) bioethical approaches to refusal by Jehovah's Witness patients. Conclusion: this scoping review mapped the literature and identified the concerns and strategies used in care for Jehovah's Witness patients who refuse transfusions of blood and blood products for religious reasons. Understanding these alternatives will be fundamental to guaranteeing safe care and preserving patient autonomy.

Objetivo: mapear los estudios que abordan la no transfusión de sangre y hemocomponentes a pacientes Testigos de Jehová. Método: revisión del alcance, siguiendo el método propuesto por el Instituto Joanna Briggs. Se realizaron búsquedas en doce bases de datos nacionales e internacionales, en octubre de 2020. No se estipuló un recorte temporal. Resultados: de los 1435 artículos encontrados en las bases de datos investigadas, 21 fueron incluidos en este estudio, sus contenidos se resumieron en tres categorías: 1) Estrategias alternativas al uso de hemocomponentes; 2) Enfoque legal en cuanto al rechazo del paciente testigo de Jehová; 3) Enfoque bioético del rechazo de un paciente testigo de Jehová. Conclusión: esta revisión de alcance permitió mapear la literatura y conocer las preocupaciones y estrategias utilizadas en la atención de los pacientes Testigos de Jehová que, por motivos religiosos, rechazan transfusiones de sangre y hemocomponentes. Comprender estas alternativas será fundamental para garantizar una atención segura y preservar la autonomía del individuo.

Hematol., Transfus. Cell Ther. (Impr.) ; 44(4): 472-477, Oct.-dec. 2022. tab
Article in English | LILACS | ID: biblio-1421523


ABSTRACT Introduction: The Zika Virus (ZIKV) is a single-stranded RNA genome virus, belonging to the family Flaviviridae, genus Flavivirus. Outbreaks around the world have demonstrated that the presence of asymptomatic viremic blood donors provides an increase in the risk of transfusion transmission (TT) and nucleic acid test (NAT) screening has been proposed to ensure the blood safety. This study implemented an "in-house" method to detect ZIKV RNA in blood sample donations. Methods: Primary plasma tubes are submitted to nucleic acid extraction on an automated platform. After extraction, the NAT set-up is performed in the robotic pipettor, in which an amplification mixture containing primers and probes for ZIKV and Polio vaccine virus (PV) are added in duplex as an internal control. The real-time polymerase chain reaction is then performed in a thermocycler, using the protocol established by the supplier. Results: From May 2016 to May 2018, 3,369 samples were collected from 3,221 blood donors (confidence coefficient 95%), of which 31 were considered false positive (0.92%), as they did not confirm initial reactivity when repeated in duplicates and 14 (0.42%) had their results invalid due to repeat failure in the internal control, 4 (0.12%), due to insufficient sample volume and 2 (0.05%), due to automatic pipettor failures. No Zika RNA reactive sample was identified. Conclusion: The test showed feasible to be incorporated into the blood screening routine. Our data do not indicate the need to screen for ZIKV RNA in São Paulo during the evaluated period. However, a generic NAT system covering a group of flaviviruses which are circulating in the region, such as DENV and YFV, among others, could be a useful tool.

Humans , Real-Time Polymerase Chain Reaction , Zika Virus , Blood Donors , Blood Transfusion , Flavivirus
Hematol., Transfus. Cell Ther. (Impr.) ; 44(3): 374-378, July-Sept. 2022. tab, graf
Article in English | LILACS | ID: biblio-1405005


ABSTRACT Introduction: Patient blood management (PBM) programs are associated with better patient outcomes, a reduced number of transfusions and cost-savings The Clinical Decision Support (CDS) systems are valuable tools in this process, but their availability is limited in developing countries This study assesses the feasibility and effectiveness of an adapted CDS system for low-income countries. Methods: This was a prospective study of the PBM program implementation, in a 200-bed tertiary hospital, between February 2019 and May 2020. Outcome measures were red blood cell (RBC), fresh frozen plasma (FFP) and platelet unit transfusions, the transfusion of a single unit of red blood cells and an RBC adequacy index (RAI). Results: Comparing the post-PBM program era with the pre-PBM system era, there was a decrease in red blood cell transfusions (p = 0.05), with an increase in single unit red blood cell transfusions (p = 0.005) and RAI (p < 0.001). Conclusions: The PBM programs, including electronic transfusion guidelines with pre-transfusion medical auditing, was associated with improved transfusion practices and reduced product acquisition-related costs.

Blood Banks/organization & administration , Blood Transfusion , Clinical Decision-Making , Medical Audit , Patient Care Management , Transfusion Medicine , Transfusion Reaction
Article | IMSEAR | ID: sea-226374


Sickle cell anaemia is a type of haemoglobin disorder causing morbidity and mortality in many countries. The disease is incurable and therefore requires symptomatic management to improve quality of life. Because the alternative system of medicine can play a significant role in the management of quality of life in sickle cell anaemia, lot many combinations and formulations are attempted across many countries. Unfortunately, very few have reached a preclinical and clinical research level. In the current case study, T-AYU-HM Premium was evaluated as per the standard parameters, and a clinical evaluation considering its effect and safety was performed in this case report of a 24-year-old male with a history of sickle cell disease in hereditary. History was 8 times blood transfusion and 7 times hospitalization in past two year. He was infected with covid-19 and hospitalized, recovered with T-AYU-HM Premium only. Next month because of joint pain, fever, and weakness he visited the daycare clinic. On complete physical and laboratory examination he was started on T-AYU-HM Premium 300mg two tablets twice a day. During 6 months of treatment, he had complained of pain only thrice for which analgesics were prescribed, and no blood transfusion was required. During this 6 month period, there is a remarkable improvement in his haemoglobin, red blood corpuscles, white blood cells, and platelets. There were no untoward complaints from him suggesting that T-AYU-HM Premium exhibited its potential in sustaining the cellular integrity and thereby preventing the lysis of red blood corpuscles. The improvement in laboratory parameters, clinical parameters and established studies indicated that T-AYU-HM Premium is safe and exhibit an observational effect on red blood corpuscles of sickle cell anaemia patient.