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1.
Braz. j. oral sci ; 22: e239246, Jan.-Dec. 2023. tab
Article in English | LILACS, BBO | ID: biblio-1399767

ABSTRACT

Aim: To assess the prevalence of cleft lip and/or cleft palate (CL/P) and associated variables in neonates admitted to neonatal intensive care units (ICU). Methods: Medical charts for neonates born and admitted to the ICU between 2012 and 2018 were reviewed. Obstetric and neonatal variables were collected by a trained researcher. In the case group, all neonates with CL/P were included. The control group was formed by matching sex, prematurity and month of birth using random number generation. Neonates with congenital malformations were excluded from the control group. Adjusted logistic regression was used (p<0.05). Results: The prevalence of CL/P was 0.43% (n=15). Five cases were excluded, as pairing was not possible. Twenty neonates were included in the control group. In the final multivariate model, CL/P was only associated with increased maternal age. For each year of increase in maternal age, neonates had a 35.2% higher chance of presenting CL/P (95% confidence interval: 1.021­1.792). Conclusions: Higher maternal age was associated with higher occurrence of CL/P in neonates admitted to the ICU. No other neonatal or maternal independent variables were associated with CL/P. Due to missing data, interpretation of study results must be approached with caution


Subject(s)
Congenital Abnormalities/epidemiology , Infant, Newborn , Intensive Care Units, Neonatal , Medical Records , Cleft Lip/epidemiology , Cleft Palate/epidemiology , Maternal Age
2.
Braz. j. oral sci ; 21: e226343, jan.-dez. 2022. ilus
Article in English | LILACS, BBO | ID: biblio-1393030

ABSTRACT

Aim: to evaluate the surgical effects of two rehabilitation protocols on dental arch occlusion of 5-year-old children with or without cleft lip and palate. Methods: this is a retrospective longitudinal study the sample comprised 45 digitized dental casts divided into followed groups: Group 1 (G1) ­ children who underwent to cheiloplasty (Millard technique) at 3 months and to one-stage palatoplasty (von Langenbeck technique) at 12 months; Group 2 (G2) ­ children who underwent to cheiloplasty (Millard technique) and two-stage palatoplasty (Hans Pichler technique for hard palate closure) at 3 months and at 12 months to soft palate closure (Sommerlad technique); and Group 3 (G3) ­ children without craniofacial anomalies. Linear measurements, area, and occlusion were evaluated by stereophotogrammetry software. Shapiro-Wilk test was used to verify normality. ANOVA followed by posthoc Tukey test and Kruskal-Wallis followed by posthoc Dunn tests were used to compared groups. Results: For the measures intercanine distance (C-C'), anterior length of dental arch (I-CC'), and total length of the dental arch (I­MM'), there were statistical differences between G1x G3 and G2xG3, the mean was smaller for G1 and G2. No statistically significant differences occurred in the intermolar distance and in the dental arch area among groups. The occlusion analysis revealed significant difference in the comparison of the three groups (p=0.0004). Conclusion: The surgical effects of two rehabilitation protocols affected the occlusion and the development of the anterior region of the maxilla of children with oral clefts when compared to children without oral clefts.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Surgery, Oral , Clinical Protocols , Cleft Lip , Cleft Palate , Dental Arch , Dental Occlusion
3.
J. Health Biol. Sci. (Online) ; 10(1): 1-4, 01/jan./2022. ilus
Article in English | LILACS | ID: biblio-1370925

ABSTRACT

Introduction: orofacial clefts are common congenital malformations with an important social, psychological, and economic impact. The treatment of this condition may include different surgical procedures that previously require an adequate oral condition. Case report: we report a case of dental treatment before palatoplasty in a male patient of 17 years-old with bilateral cleft lip and palate and lesion in the jugal mucosa. Final considerations: the adequacy of the oral environment is a fundamental step in the treatment of patients with orofacial clefts and aims to restore oral health regardless of the degree of complexity of the dental treatment through the reduction of the pathogenic microbiota, elimination of retentive niches, instructions on diet and adequate oral hygiene and constant patient motivation.


Objetivos: as fissuras orofaciais são malformações congênitas comuns, com importante impacto social, psicológico e econômico. O tratamento dessa condição pode incluir vários procedimentos cirúrgicos que requerem previamente uma adequada condição bucal. Relato de caso: Relatamos o caso de tratamento odontológico prévio a palatoplastia em um paciente do gênero masculino de 17 anos de idade, com fissura transforame incisivo bilateral e lesão em mucosa jugal. Considerações finais: A adequação do meio bucal é uma etapa fundamental no tratamento de pacientes com fissuras orofaciais e visa restabelecer a saúde bucal independente do grau de complexidade do tratamento odontológico por meio da redução da microbiota patogênica, eliminação de nichos retentivos, orientações sobre dieta e higiene bucal adequada e motivação constante do paciente.


Subject(s)
Cleft Palate , Oral Hygiene , Palate , Cleft Lip , Cissus , Dental Caries , Craving , Mouth Rehabilitation
4.
Braz. j. otorhinolaryngol. (Impr.) ; 88(4): 594-601, July-Aug. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1394164

ABSTRACT

Abstract Introduction: One of the main goals of the team approach in management of oro-facial clefts is to help the children with cleft palate have adequate speech development. Objective: The present study aimed to investigate the prevalence of articulation and resonance disorders following palate closure in children who were visited for routine examination by the Isfahan Cleft Care Team between 2011 and 2015, and to study the impact of cleft type and age at the time of palatoplasty on speech outcomes. Methods: Clinical records of 180 preschool children with repaired cleft palate were reviewed. The percentage of children demonstrating hypernasality, nasal emission, nasal turbulence, and compensatory misarticulations was calculated. The relationship between cleft type and age at the time of palatal surgery, as independent variables, and speech outcomes were examined. Results: 67.7 and 64.5 percent of the children demonstrated respectively moderate/severe hypernasality and nasal emission, and 71.1 percent produced compensatory misarticulations. Age at the time of palatal repair was significantly associated with compensatory misarticulations and also with moderate/severe hypernasality. The prevalence of compensatory misarticulations, significant hypernasality, nasal emission and also nasal turbulence was not significantly different in various types of cleft. Conclusions: We observed a high prevalence of different speech disorders in preschool children with repaired cleft palate compared to other studies. This can be partly due to late palatal repair in the studied population. Despite many advances in cleft palate management programs in Iran, there are still many children who do not access the interdisciplinary team cares in their early childhood. We should, therefore, try to increase accessibility of appropriate and timely management services to all Iranian children with cleft lip/palate.


Resumo Introdução: Um dos principais objetivos da abordagem em equipe no tratamento das fendas orofaciais é contribuir para que as crianças com fenda palatina tenham um desenvolvimento adequado da fala. Objetivo: Investigar a prevalência de distúrbios de articulação e ressonância após o reparo da fenda palatina em crianças acompanhadas no Isfahan Cleft Care Team entre 2011 e 2015; e avaliar o impacto do tipo de fenda e da idade na época da palatoplastia nos resultados da fala. Método: Os prontuários de 180 pré-escolares com fenda palatina reparada foram revisados para determinação da porcentagem de crianças com hipernasalidade, emissão nasal, turbulência nasal e distúrbios articulatórios compensatórios. A relação entre o tipo de fenda e a idade no momento da cirurgia de palato, como variáveis independentes, e os resultados de fala também foram avaliados. Resultados: Das crianças, 67,7% e 64,5% apresentavam hipernasalidade moderada/grave e emissão nasal, respectivamente, e 71,1% tinham distúrbios articulatórios compensatórios. A idade no momento do reparo do palato foi significantemente associada aos distúrbios articulatórios compensatórios e também à hipernasalidade moderada/grave. A prevalência de distúrbios articulatórios compensatórios, hipernasalidade significativa, emissão nasal, assim como da turbulência nasal, não foi significantemente diferente nos vários tipos de fenda. Conclusão: Observou-se maior prevalência de diferentes alterações de fala em pré-escolares com fenda palatina reparada em comparação a outros estudos. Isso pode ser parcialmente decorrente do reparo palatino tardio na população estudada. Apesar dos muitos avanços nos programas de tratamento de fenda palatina no Irã, ainda existem muitas crianças que não têm acesso aos cuidados de uma equipe interdisciplinar na primeira infância. Devemos, portanto, tentar aumentar a acessibilidade de serviços de tratamento apropriados e oportunos para todas as crianças iranianas com fenda labiopalatina.

5.
Braz. j. otorhinolaryngol. (Impr.) ; 88(2): 187-193, Mar.-Apr. 2022. graf
Article in English | LILACS | ID: biblio-1374725

ABSTRACT

Abstract Introduction: Individuals with cleft palate can present with velopharyngeal dysfunction after primary palatoplasty and require a secondary treatment due to insufficiency. In these cases, the pharyngeal bulb prosthesis can be used temporarily while awaiting secondary surgery. Objective: This study aimed to investigate the outcome of treatment of hypernasality with pharyngeal bulb prosthesis in patients with history of cleft palate presenting with velopharyngeal insufficiency after primary palatal surgery. We hypothesized that the use of the pharyngeal bulb prosthesis is an effective approach to eliminate hypernasality related to velopharyngeal insufficiency in patients with cleft palate. Methods: Thirty speakers of Brazilian Portuguese (15 males and 15 females) with operated cleft palate, ages ranging from 6 to 14 years (mean: 9 years; SD = 1.87 years), participated in the study. All patients were fitted with a pharyngeal bulb prosthesis to manage velopharyngeal insufficiency while they were awaiting corrective surgery to be scheduled. Auditory-perceptual analysis of speech recorded in the conditions with and without pharyngeal bulb prosthesis were obtained from three listeners who rated the presence or absence of hypernasality for this study. Results: Seventy percent of the patients eliminated hypernasality while employing the pharyngeal bulb prosthesis, while 30% still presented with hypernasality. The comparison was statistically significant (p < 0.001). Conclusion: The use of the pharyngeal bulb prosthesis is an effective approach to eliminate hypernasality related to velopharyngeal insufficiency.


Resumo Introdução: Indivíduos com fissura palatina podem apresentar disfunção velofaríngea após a palatoplastia primária e necessitam de um secundário devido à insuficiência velofaríngea. Nesses casos, o obturador faríngeo pode ser usado temporariamente enquanto se aguarda uma cirurgia secundária. Objetivo: Investigar o resultado do tratamento da hipernasalidade com o uso de obturador faríngeo em pacientes com histórico de fissura palatina que apresentam insuficiência velofaríngea após a palatoplastia primária. Nossa hipótese é que o uso do obturador faríngeo seja uma abordagem eficaz para eliminar a hipernasalidade relacionada à insuficiência velofaríngea em pacientes com fissura palatina Método: Participaram do estudo 30 indivíduos falantes do Português Brasileiro (15 homens e 15 mulheres) com fissura palatina operada, de 6 a 14 anos de idade (média: 9 anos; DP = 1,87 anos). Todos os pacientes receberam obturador faríngeo para o tratamento da insuficiência velofaríngea, enquanto aguardavam vaga para a cirurgia secundária. A análise perceptivo-auditiva da fala, realizada nas condições com e sem obturador faríngeo, foi realizada por três ouvintes, quanto à presença e ausência da hipernasalidade. Resultados: 70% dos pacientes eliminaram a hipernasalidade de fala com o uso do obturador faríngeo, enquanto 30% não eliminaram. A comparação foi estatisticamente significante (p < 0,001). Conclusão: O uso temporário do obturador faríngeo é uma abordagem efetiva para eliminar a hipernasalidade decorrente da insuficiência velofaríngea.


Subject(s)
Velopharyngeal Insufficiency/surgery , Velopharyngeal Insufficiency/etiology , Voice Disorders , Nose Diseases , Cleft Palate/surgery , Cleft Palate/complications , Prostheses and Implants , Speech , Treatment Outcome
6.
Braz. j. otorhinolaryngol. (Impr.) ; 88(1): 22-27, Jan.-Feb. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1364567

ABSTRACT

Abstract Introduction The cleft palate is one of the most common congenital anomalies treated by plastic surgeons. The cleft width increases the tension of repair and necessitates excessive dissection that might affect maxillary growth. Decreasing the width of cleft minimize tension, dissection and may limit the impact on maxillary growth. Objectives The purpose of the study was to evaluate the effect of nasal layer closure of the hard palate at the time of cleft lip repair in patients with complete cleft lip and palate, to demonstrate the efficacy of narrowing the gap and to reduce the incidence of fistulae or other complications. Methods Thirty patients less than 1 year of age were included in this prospective observational study. A superiorly based vomer flap was used to repair the nasal layer of the cleft hard palate at the time of primary cleft lip repair. 12-14 weeks after the vomer flap, the cleft soft and hard palate was definitively repaired. Alveolar and palatal gaps were recorded during the 1st and 2nd operations to demonstrate the reduction of the gap defect. Results The mean reduction of the alveolar cleft width in patients who had a vomer flap in the first stage was 4.067 mm and the mean reduction of the palatal gap was 4.517 mm. Only 3 patients developed small fistula on the repaired nasal layer that was discovered and corrected during definitive palatoplasty. Conclusion Nasal layer closure is a simple surgical technique that can be used to close the hard palate at the time of cleft lip repair. It is a valuable addition to cleft lip and palate repair that may prevent some cleft palate surgical complications.


Resumo Introdução A fenda palatina é uma das anomalias congênitas mais comumente tratadas por cirurgiões plásticos. A largura da fenda aumenta a tensão do reparo e requer dissecção extensa que pode afetar o crescimento maxilar. Diminuir a largura da fenda minimiza a tensão, a dissecção e pode limitar o impacto no crescimento maxilar. Objetivos Avaliar o efeito do fechamento da camada nasal do palato duro no momento do reparo da fenda labial em pacientes com fenda labiopalatina completa, demonstrar a eficácia do estreitamento do gap (abertura) e reduzir a incidência de fístulas ou outras complicações. Método Trinta pacientes com menos de um ano foram incluídos neste estudo observacional prospectivo. Um retalho do vômer de base superior foi usado para reparar a camada nasal da fenda do palato duro no momento do reparo primário da fenda labial. Doze a 14 semanas após o retalho do vômer, a fenda no palato mole e duro foi submetida a reparo. Os gaps alveolares e palatais foram registradas durante a 1ª e a 2ª cirurgias para demonstrar a redução do defeito. Resultados A redução média da largura da fenda alveolar nos pacientes que apresentaram retalho do vômer no primeiro estágio foi de 4,067 mm e a redução média do gap palatino foi de 4,517 mm. Apenas três pacientes desenvolveram uma pequena fístula na camada nasal submetida a reparo, que foi identificada e corrigida durante a palatoplastia definitiva. Conclusão O fechamento da camada nasal é uma técnica cirúrgica simples que pode ser usada para fechar o palato duro no momento do reparo da fenda labial. É uma adição valiosa ao reparo de fenda labial e palatina que pode prevenir algumas complicações cirúrgicas da fenda palatina.

7.
Odontol. sanmarquina (Impr.) ; 25(1): e20573, ene.-mar. 2022.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1358535

ABSTRACT

Objetivo. Reportar el perfil epidemiológico y presencia de polimorfismos de IFR6 (rs2235371) y TGFA (rs3771494) en individuos con labio y paladar hendido (LPH) no sindrómico. Métodos. Serie de casos, centrado en individuos con hendiduras orofaciales (HO), remitidos a la Facultad de Odontología de Durango, México, para su revisión y valoración dentro del periodo comprendido de enero-2018 a diciembre-2019. Se obtuvo información de interés para el estudio sobre las características del embarazo y anteceden- tes familiares, de las madres de los individuos. Para el análisis y descripción de los datos se utilizó el paquete estadístico R Studio. Resultados. El total de casos estudiados fue de 24. Se presentó una mayor frecuencia de hombres (67%), la mayoría de los individuos tuvieron el diagnóstico de LPH al nacer (75%), extensión de afección completa (75%), el lado izquierdo afectado (63%), y cirugías correctivas (62%). Solo el 4% estuvo ex- puesto al tabaquismo materno (activo y pasivo), el 96% tuvo adecuada ingesta de ácido fólico y hierro; el genotipo de riesgo para TGFA (rs3771494) se presentó en el 15% de labio hendido y en el 8% del LPH, y para IFR6 (rs2235371) solo en el 10% del LPH. Conclusiones. La presencia de factores ambientales, genéticos, y el estilo de vida ma- terno mostrado en otras poblaciones, podrían no ser los mismos que intervengan en la aparición y desarrollo de HO no sindromicas de nuestra localidad, además, la presencia de los genotipos homocigotos polimórficos de los genes de interés podría no condicionar el desarrollo de HO.


Objective. To report the epidemiological profile and the presence of polymorphisms of the IFR6 (rs2235371) and TGFA (rs3771494) genes, in individuals with non-syndromic cleft lip and palate. Methods. Case series study, focused on individuals with orofacial clefts, referred to the School of Dentistry of Durango, Mexico, for review and assessment within the period from January 2018 to December 2019. Information of interest for the study was obtained on the characteristics of pregnancy and family history of the mothers of the individuals. For the analysis and description of the data, the statistical software R Studio was used. Results. There was a higher frequency of men (67%), most of the individuals had the diagnosis of cleft lip and palate at birth (75%), the extension of the complete affection (75%), the left side affected (63%), and corrective surgeries (62%). Only 4% were exposed to maternal smoking (active and passive), 96% had adequate folic acid and iron intake; the risk genotype for TGFA (rs3771494 [G/G]) was present in 15% of cleft lip and 8% of cleft lip and palate, and for IFR6 (rs2235371 [T/T]) only in 10% of cleft lip and palate. Conclusions. The presence of environmental and genetic factors, as well as the maternal lifestyle shown in other populations, may not be the same as those involved in the appearance and development of non-syndromic orofacial clefts in our locality, in addition, the presence of homozygous polymorphic genotypes of the genes of interest could not condition the development of orofacial clefts.

8.
Acta méd. peru ; 39(1): 40-44, ene.-mar. 2022. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1383384

ABSTRACT

RESUMEN Introducción y objetivos : Determinar si el tipo de fisura labio palatina está asociada a mayor riesgo de alteración de la trompa de Eustaquio. Materiales y métodos : Se realizó un estudio descriptivo serie de casos con análisis inferencial de niños operados de fisura labiopalatina en el Hospital San Bartolomé durante el 2018 y 2019. Resultados : Se evaluó a un total de 48 pacientes a quienes se les realizó timpanometría, encontrándose 62,5 % varones (n=30) y 37,5 % mujeres (n=18) y la media de edad fue de 1,3 años, para determinar el tipo de fisura labiopalatina se usó la clasificación de Veau, el tipo más frecuente hallado fue Veau tipo III, con 62,5 % (n=30), siendo la menos frecuente Veau tipo I con 4,2 % (n=2). La evaluación de la función de la trompa de Eustaquio se realizó mediante timpanometría definiéndose como patológica la curva tipo B, en el grupo de estudio se encontró una prevalencia global de curvas tipo B de 66,7 % (n= 32), mientras que las curvas A y C, tuvieron 33,3 % (n=16). La probabilidad que el diagnóstico Veau IV tenga curvas tipo B de forma más frecuentes que los otros tipos, mediante la prueba Binomial fue significativo. (p=0,000038<0,05). Conclusiones : El tipo de fisura palatina mayormente asociado con alteración de la función del oído medio, expresado mediante curvas de timpanometría tipo B, es la fisura tipo IV según clasificación de Veau, esta relación es estadísticamente significativa.


ABSTRACT Introduction and objectives : The objective of this study is to determine if the type of cleft lip and palate is associated with a higher risk of alteration of the Eustachian tube. Materials and methods : A descriptive case series study was carried out with an inferential analysis of children operated on for cleft lip and palate at the San Bartolomé hospital during the years 2018 and 2019. Results : 48 patients with tympanometry were evaluated, 62.5% male (n = 30) and 37.5% female (n = 18), the mean age was 1.3 years. The type of cleft lip and palate was determined using the Veau classification, the most frequent type found was Veau type III: 62.5% (n = 30), the least frequent type was Veau I with 4.2% (n = 2). The evaluation of the function of the Eustachian tube was performed with tympanometry, defining the type B curve as pathological. In the study group, there was an overall prevalence of type B curves of 66.7% (n = 32), while type A and C curves were 33.3% (n = 16). The probability that the Veau IV crack type has an association with type B curves more frequently than the other types, using the Binomial test, was significant. (p = 0.000038 <0.05). Conclusions : The type of cleft palate that is most associated with impaired middle ear function, expressed by type B tympanometry curves, is type IV cleft according to Veau's classification, this relationship is statistically significant.

9.
J. appl. oral sci ; 30: e20220120, 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1386012

ABSTRACT

Abstract Oral cleft surgical repairs are performed using different techniques worldwide. Objective To evaluate and compare the development of the dental arches of children with unilateral cleft lip and palate before and after the primary surgeries performed with different techniques at the first months and six years of life. Methodology This is a retrospective longitudinal study. The sample comprised 56 dental casts divided int the following groups: Group 1 (G1) - cheiloplasty (Millard technique) at three months and one-step palatoplasty (von Langenbeck technique) at 12 months; and Group 2 (G2) - cheiloplasty (Millard technique) and two-step palatoplasty: anterior hard palate closure (Hans Pichler technique) at three months and posterior soft palate closure (Sommerlad technique) at 12 months. The digitized dental casts were evaluated at three months - pre-surgical (T1) and six years of life- post-surgical (T2). The following linear measurements were analyzed: intercanine (C-C'), intertuberosity (T-T') distances; anterior dental arch (I-CC'), anterior intersegment (I-C'), and total arch (I-TT') lengths. The palate area was also measured. Parametric and non-parametric tests were applied (p<0.05). Results In G1, the intragroup comparison showed statistically significant smaller I-CC' and I-C' at T2 (p=0.001 and p<0.001, respectively), while T-T', I-TT', and area comparisons were significantly greater (p<0.001, p=0.002, and p<0.001, respectively). In G2, the intragroup comparison exhibited statistically significant smaller C-C' and I-C' at T2 (p=0.004, for both), whereas T-T', I-TT' and area comparisons were significantly greater (p<0.001, p=0.004, and p<0.001, respectively). At T2, the intergroup analysis revealed that G1 had a statistically significant smaller I-CC' (p=0.014). The analysis of the intergroup differences (∆=T2-T1) showed that G1 had a statistically smaller I-CC' (p=0.043). Conclusion The two-step palatoplasty showed a more favorable prognosis for the maxillary growth than one-step palatoplasty in children with oral clefts.

10.
CoDAS ; 34(6): e20210152, 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1364753

ABSTRACT

ABSTRACT Purpose The present study is aimed towards determining and comparing normative nasalance scores in Chilean Spanish-speaking adult men and women. Methods 40 women (age range 18 to 35, X = 25.79, SD = 5.83) and 36 men (age range 18 to 35, X = 26.45, SD = 4.08) were invited to participate, all of them without any previous speech therapy, neurological pathologies, intellectual deficits, hearing loss, syndromes, or other diagnosed pathologies that could impact speech production. A study of proper velopharyngeal function was performed, using a perceptual resonance evaluation. Nasalance was determined using a model 6450 Nasometer, during the reading of three standardized speech samples in Spanish: a nasal passage (NP), an oronasal passage (ONP), and an oral passage (OP). Also, the nasalance distance was calculated. Genders were compared using Wilcoxon tests for independent samples. Results The NP presented the highest percentage of nasalance, with 52.13% (± 4.73), followed by the ONP with 25.38% (± 3.7), and finally the OP, which presented the lowest value of 14.15% (± 5.03). Meanwhile, nasalance distance was 37.98% (± 5.32). Finally, no significant differences were observed when comparing the nasalance between genders (p >0.05). Conclusion The nasalance values obtained were similar to those observed for other Spanish speakers. Also, male and women showed similar scores. The results of this study are a contribution to the indirect assessment of velopharyngeal function in Chilean adults.


RESUMEN Objetivo El presente estudio tiene como objetivo determinar y comparar puntajes normativos de nasalancia en hombres y mujeres chilenos de habla hispana. Método Participaron 40 mujeres (rango de edad de 18 a 35, X = 25.79, DE = 5.83) y 36 hombres (rango de edad de 18 a 35, X = 26.45, DE = 4.08), todos sin ningún antecedente de tratamiento fonoaudiológico, patologías neurológicas, déficit intelectual, hipoacusia, síndromes u otras patologías diagnosticadas que podrían afectar la producción del habla. La adecuada función velofaríngea fue determinada en vivo a través de una evaluación perceptual de la resonancia. La nasalancia se determinó utilizando un Nasometer modelo 6450, durante la lectura de tres muestras de habla estandarizadas en español: un párrafo nasal (PN), un párrafo oronasal (PON) y un párrafo oral (PO). Además, se calculó la distancia de nasalancia. La comparación entre ambos sexos fue realizada con el test de Wilcoxon para muestras independientes. Resultados El PN presentó el mayor porcentaje de nasalancia con 52.13% (± 4.73), seguido del PON con 25.38% (± 3.7), y finalmente el PO, que presentó el valor más bajo de 14.15% (± 5.03). En tanto, la distancia de nasalancia fue del 37.98% (± 5.32). Por último, no se observaron diferencias significativas al comparar entre ambos sexos (p> 0.05). Conclusión Los valores de nasalancia obtenidos fueron similares a los observados para otros hispanohablantes. Además, hombres y mujeres mostraron puntuaciones similares. Los resultados de este estudio son una contribución a la evaluación indirecta de la función velofaríngea en adultos chilenos.

11.
Braz. dent. sci ; 25(3): 1-7, 2022. tab, ilus
Article in English | LILACS, BBO | ID: biblio-1391021

ABSTRACT

Objective: Compare the palatal volume in children with unilateral cleft lip and palate before and after two surgical protocols. Material and Methods: Retrospective data collection was performed in a specialized hospital. The sample comprised 120 digitized dental models divided into, Group 1 (G1) ­ participants submitted to cheiloplasty at 3 months (Millard technique) and one-step palatoplasty at 12 months (von Langenbeck technique); Group 2 (G2) ­ participants submitted to cheiloplasty (Millard technique) and hard palate closure (Hans Pichler technique) at 3 months and soft palate closure at 12 months (Sommerlad technique). The dental models were evaluated at Time 1 (T1): before primary plastic surgeries, Time 2 (T2): 1st post-surgical phase, and Time 3 (T3): 2nd post-surgical phase. The volume was measured through stereophotogrammetry system software. Parametric and non-parametric statistical tests were applied (α=5%). Results: The intragroup analysis revealed that G1 had a statistically significant increase in volume at T2 followed by a reduction at T3 (p=0.003); G2 showed a statistically significant increase of dental arch volume between T1 and T2 (p=0.001). There was no statistically significant difference in the intergroup and gender analyses (p>0.05). Conclusion: The surgical protocol influenced the palatal volume of children with unilateral cleft lip and palate. This study suggested that two-step palatoplasty protocol has a tendency to be more appropriate.(AU)


Objetivo: Comparar o volume palatino em crianças com fissura unilateral de lábio e palato antes e após dois protocolos cirúrgicos. Material e Métodos: A coleta de dados retrospectiva foi efetuada em um hospital especializado. A amostra foi composta por 120 modelos dentários digitalizados divididos em, Grupo 1 (G1) ­ participantes submetidos a queiloplastia aos 3 meses de vida (técnida de Millard) e a palatoplastia em única etapa aos 12 meses (técnica de von Langenbeck); Grupo 2 (G2) ­ participantes submetidos a queiloplastia (técnica de Millard) e fechamento do palato duro (técnica de Hans Pichler) aos 3 meses de vida e fechamento do palate mole aos 12 meses (técnica de Sommerlad). Os modelos dentários foram avaliados em Tempo 1 (T1): antes das cirurgias plásticas primárias, Tempo 2 (T2):1ª fase pós-cirúrgica e Tempo 3 (T3): 2ª fase pós-cirúrgico. O volume foi mensurado por meio do software do sistema de estereofotogrametria. Testes estatísticos paramétricos e não-paramétricos foram utilizados (α=5%). Resultados: As análises intragrupos indicaram que G1 apresentou aumento estatisticamente significante em T2 seguido de redução em T3 (p=0.003). G2 apresentou crescimento estatisticamente significativo do volume palatino entre T1 e T2 (p=0.001). Não houve diferença estatisticamente significante nas análises intergrupos e entre gêneros (p>0.05). Conclusão: O protocolo cirúrgico influenciou o volume palatino das crianças com fissura unilateral de lábio e palato. Este estudo sugeriu que o protocolo da palatoplastia em duas etapas possui uma tendência de ser mais apropriado.(AU)


Subject(s)
Cleft Lip , Cleft Palate , Oral Surgical Procedures , Imaging, Three-Dimensional , Dental Arch
12.
Pesqui. bras. odontopediatria clín. integr ; 22: e210085, 2022. tab, graf
Article in English | LILACS, BBO | ID: biblio-1386809

ABSTRACT

Abstract Objective: To assess the effect of the three types of unilateral cleft lip (UCL) [cleft lip only, cleft lip and alveolus, and cleft lip alveolus and palate] on the outcome of the repair. Material and Methods: This study was a case series of effect of types of UCL on the outcome of the repair. Fifteen subjects each were in three UCL phenotypes groups. Evaluation of the scar, lip, and nose was done qualitatively by both parents/guardians and professionals using a modified form of the criteria described by Christofides et al. (2006). Results: In the assessment of the surgical scar, the parents found a difference between the three types of cleft in terms of texture, shape, and width of the scar and presence of columella deviation. The professional assessors, however, only found the three types of cleft to be different in the presence of alar flattening. Conclusion: Differences truly exist in the outcome of surgical repair of the three types of unilateral cleft lip, especially in the aesthetics of the nose and in the width and shape of the residual lip scar. Thus, it is important to consider this in the assessment of UCL repair because putting the subtypes together might have a negative impact on the assessment.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Surgical Procedures, Operative , Congenital Abnormalities/pathology , Cleft Lip/surgery , Cleft Palate/surgery , Chi-Square Distribution , Prospective Studies , Cleft Lip/pathology
13.
CoDAS ; 34(3): e20210069, 2022. tab
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1356161

ABSTRACT

RESUMO Objetivo Investigar a efetividade de proposta de classificação da mímica facial (MF), e sua correlação com avaliação objetiva do fechamento velofaríngeo (FVF). Método Vinte indivíduos com fissura labiopalatina reparada foram submetidos à medida da área velofaríngea por meio da rinomanometria e à gravação de amostra de fala. A MF foi classificada em dois momentos, por três fonoaudiólogas. Inicialmente as avaliadoras classificaram a MF, utilizando critérios próprios, em: 1=MF ausente; 2=leve; 3=moderada; 4=grave. Posteriormente, foram submetidas a um treinamento com o estabelecimento dos seguintes critérios de classificação: 1=MF normal; 2=movimento somente de nariz ou terço superior da face; 3=movimento acentuado de nariz ou terço superior da face; 4=movimento de nariz e terço superior da face e, classificaram a MF utilizando os critérios estabelecidos. Concordância intra e interavaliadores foram calculadas pelo coeficiente Kappa ponderado. A correlação entre os resultados das etapas com o FVF foi feita pelo coeficiente de correlação de Spearman. Resultados Na primeira etapa, a concordância interavaliadores variou de regular a substancial e na segunda, de substancial a quase perfeita. A concordância intra-avaliadores variou de moderada a quase perfeita na primeira etapa, e de moderada a substancial, na segunda etapa. A correlação entre a MF e área velofaríngea na primeira e na segunda etapa foi positiva e significativa. Conclusão A proposta de julgamento da MF mostrou-se efetiva na determinação do sintoma e confiável no diagnóstico da gravidade da disfunção velofaríngea. A correlação significativa entre os métodos perceptivo e instrumental sugere que a MF pode ser utilizada na previsão do FVF.


ABSTRACT Purpose To investigate the effectiveness of a proposal for classification of facial grimace (FG) and its correlation with objective evaluation of velopharyngeal closure (VPC). Methods Twenty individuals with repaired cleft lip and palate underwent velopharyngeal area measurement by means of rhinomanometry and speech sample recording. The FG was rated in two steps, by three speech-language pathologists. First the evaluators rated the FG using their own criteria as: 1= absent FG; 2=mild; 3=moderate; 4=severe. Subsequently, they were submitted to a training session that established the following FG rating criteria: 1=absent FG; 2=movement only of the nose or upper third of the face; 3=strong movement of the nose or upper third of the face; 4=movement of the nose and upper third of the face. The evaluators rated the FG using the established criteria. Intra- and inter-rater agreement were calculated using weighted Kappa coefficient. Correlation between the two stage ratings with the VPC was calculated by Spearman's correlation coefficient. Results In the first stage inter-rater agreement ranged from fair to substantial; in the second stage, from substantial to almost perfect. Intra-rater agreement ranged from moderate to almost perfect in the first stage, and from moderate to substantial in the second stage. The correlation between FG and velopharyngeal area was positive and significant in both stages. Conclusion The proposed FG judgement proved to be effective in determining the symptom and reliable in diagnosing the severity of velopharyngeal dysfunction. The significant correlation between perceptual and instrumental methods suggests that FG can be used in predicting VPC.

14.
Dental press j. orthod. (Impr.) ; 27(3): e2220233, 2022. tab, graf
Article in English | LILACS-Express | LILACS, BBO | ID: biblio-1384692

ABSTRACT

ABSTRACT Objective: The aim of this study was to compare the occlusal changes of rapid maxillary expansion (RME) and slow maxillary expansion (SME) in patients with unilateral complete cleft lip and palate (UCLP), by means of digital dental models. Methods: Group RME was composed by 22 patients (13 males and 9 females), with mean age of 9.9 years, treated with rapid maxillary expansion with Hyrax appliance in Center 1. Group SME was composed by 29 patients (14 females and 15 males), with mean age of 10.7 years, treated with slow maxillary expansion with quad-helix appliance in Center 2. Digital dental models of the maxillary dental arch were obtained immediately pre-expansion (T1) and 6-month post-expansion (T2). Transversal distances, arch perimeter, arch length, palatal depth, palatal volume and posterior tooth inclination were digitally measured. Interphase and intergroup comparisons were performed with paired t-test and independent t-test, respectively. Results: Intercanine expansion was 4 to 5mm in both groups, and increase in the intercanine distance was similar for both groups. RME group showed a greater increase in arch distances at the region of permanent premolar and molars, compared to SME group. Arch perimeter increase was greater for RME group, compared to SME. No differences were found for arch length, palatal depth, palatal volume and posterior tooth buccal tipping. Conclusion: RME and SME produced similar dentoalveolar outcomes, with greater amount of expansion on RME group.


RESUMO Objetivo: O objetivo do presente estudo foi comparar, por meio de modelos digitais, as alterações oclusais após a expansão rápida da maxila (ERM) e após a expansão lenta da maxila (ELM) em pacientes com fissura labiopalatina completa unilateral (FLPU). Métodos: O grupo ERM foi composto por 22 pacientes (13 homens e 9 mulheres), com idade média de 9,9 anos, tratados com expansão rápida da maxila com aparelho Hyrax no Centro 1. O grupo ELM foi composto por 29 pacientes (14 mulheres e 15 homens), com idade média de 10,7 anos, tratados com expansão lenta da maxila com aparelho quadri-hélice no Centro 2. Modelos digitais da arcada dentária superior foram obtidos imediatamente pré-expansão (T1) e seis meses pós-expansão (T2). Distâncias transversais, perímetro da arcada, comprimento da arcada, profundidade do palato, volume do palato e inclinação dos dentes posteriores foram medidos digitalmente. As comparações interfases e intergrupos foram realizadas com teste t pareado e teste t independente, respectivamente. Resultados: A expansão da arcada na região dos caninos foi de 4 a 5 mm em ambos os grupos, e o aumento na distância intercaninos foi semelhante nos dois grupos. O grupo ERM apresentou maior aumento nas distâncias entre pré-molares e molares permanentes, em comparação ao grupo ELM. O aumento do perímetro da arcada foi maior para o grupo ERM, em relação ao ELM. Não foram encontradas diferenças para comprimento da arcada, profundidade do palato, volume do palato e inclinação vestibular dos dentes posteriores. Conclusão: ERM e ELM produziram resultados dentoalveolares semelhantes, com maior quantidade de expansão no grupo ERM.

15.
Rev. Esc. Enferm. USP ; 56: e20210252, 2022. tab, graf
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1356742

ABSTRACT

Abstract Objective: To identify the main nursing diagnoses and interventions in children in the immediate postoperative period of palatoplasty. Method: Documentary and retrospective study, developed in a Brazilian public and tertiary hospital, between August and September 2020. Children who underwent only palatoplasty, between January and December 2019, aged between 10 and 24 months, were included. Those with medical syndromes and/or comorbidities were excluded. The Theoretical Framework of Basic Human Needs and the NANDA International and Nursing Interventions Classification Taxonomies were used. Data underwent descriptive statistical analysis. Results: The sample consisted of 126 children. Psychobiological needs such as oxygenation, hydration, nutrition, elimination, cutaneous-mucosal and physical integrity, pain and environmental perception predominated. Based on them, nine nursing diagnoses, with four focusing on the problem and five on risk, as well as 17 interventions, were identified. Conclusion: The use of standardized languages to identify affected human needs and, based on them, diagnoses and interventions, favored clinical reasoning for the construction and organization of clinical nursing practice.


RESUMEN Objetivo: identificar los principales diagnósticos e intervenciones de enfermería en niños en postoperatorio inmediato de palatoplastía. Método: estudio documental y retrospectivo, desarrollado en un hospital público y terciario brasileño, entre agosto y septiembre de 2020. Se incluyeron niños sometidos exclusivamente a palatoplastía, que realizaron la cirugía entre enero y diciembre de 2019, con edad entre 10 y 24 meses. Se excluyeron aquellos con síndromes y/o comorbidades clínicas. Se utilizó el Referencial Teórico de las Necesidades Humanas Básicas y las Taxonomías NANDA Internacional y la Nursing Interventions Classification. Los datos fueron sometidos al análisis estadístico descriptivo. Resultados: la muestra constó de 126 niños. Predominaron las necesidades psicobiológicas: oxigenación, hidratación, nutrición, eliminación, integridad cutáneo-mucosa y física, percepción dolorosa y ambiental. A partir de eso se identificaron 9 diagnósticos de enfermería, siendo 4 con enfoque en el problema y 5 de riesgo, además de 17 intervenciones. Conclusión: la utilización de lenguajes estandarizado en la identificación de las necesidades humanas afectadas y, a partir de ellas los diagnósticos e intervenciones, favoreció el raciocinio clínico para que se construyese y se organizase la práctica clínica de enfermería.


RESUMO Objetivo: identificar os principais diagnósticos e intervenções de enfermagem em crianças em pós-operatório imediato de palatoplastia. Método: estudo documental e retrospectivo, desenvolvido em um hospital público e terciário brasileiro, entre agosto e setembro de 2020. Foram incluídas crianças submetidas exclusivamente a palatoplastia, que realizaram a cirurgia entre janeiro e dezembro de 2019, com idade entre 10 e 24 meses. Excluíram-se aquelas com síndromes e/ou comorbidades clínicas. Utilizou-se o Referencial Teórico das Necessidades Humanas Básicas e as Taxonomias NANDA Internacional e da Nursing Interventions Classification. Os dados foram submetidos a análise estatística descritiva. Resultados: a amostra constou de 126 crianças. Predominaram as necessidades psicobiológicas: oxigenação, hidratação, nutrição, eliminação, integridade cutâneo-mucosa e física, percepção dolorosa e ambiental. A partir delas foram identificados 9 diagnósticos de enfermagem, sendo 4 com foco no problema e 5 de risco, além de 17 intervenções. Conclusão: a utilização de linguagens padronizadas na identificação das necessidades humanas afetadas e, a partir delas os diagnósticos e intervenções, favoreceu o raciocínio clínico para a construção e organização da prática clínica de enfermagem.


Subject(s)
Postoperative Period , Cleft Palate , Nursing Diagnosis , Standardized Nursing Terminology , Nursing Care , Nursing Process
16.
Article in Chinese | WPRIM | ID: wpr-933924

ABSTRACT

Objective:To explore the method of sequential sector scan with 2D ultrasound through oral fissure (SSTOF) and its utilization in the cleft palate screening.Methods:Based on features of oral anatomy and ultrasonic beam, SSTOF was designed to screen cleft palate and the accuracy had been verified using specimens of aborted fetuses. This study recruited 7 154 women with singleton pregnancy who were screened for fetal malformations during 20-28 gestational weeks in the First Affiliated Hospital of Anhui Medical University from May 2020 to October 2020. In medical addition to routine screening, these subjects also underwent SSTOF to further verify its feasibility and imaging performance. Follow-up was performed by telephone and medical record review.Results:Clear images of the upper palate were acquired in five specimens of induced fetuses using SSTOF. Except for 56 cases lost to follow-up, a total of 7 098 fetuses were finally enrolled, of which 6 885 acquired satisfactory images using SSTOF, 213 did not due to inappropriate position, with a success image rate of 97%. SSTOF found cleft palate in 31cases, which were all confirmed after birth or induction, noting an accuracy rate of 100%.Conclusion:Sequential sector scan through oral fissure has a high clinical value on cleft palate screening in the second trimester with advantages of clear image, easy operation, and access to section views.

17.
Article in Chinese | WPRIM | ID: wpr-942766

ABSTRACT

@#Fibroblast growth factor 8 (FGF8) is a kind of secretory polypeptide that has crucial roles in the development of various tissues and organs. Current studies have found that FGF8 can regulate the differentiation of cranial neural crest cells by activating the mitogen-activated protein kinase (MAPK) signaling pathway and affect the establishment of mandibular arch polarity and the development of craniofacial symmetry by regulating the expression of target genes. Cleft lip with or without cleft palate, ciliopathies, macrostomia and agnathia are four developmental malformations involving the craniofacial region that seriously affect the quality of life of patients. The abnormal FGF8 signal caused by gene mutation, abnormal protein conformation or expression is closely related to the occurrence of craniofacial malformations, but the molecular mechanism and signaling pathway underlying these malformations have not been fully elucidated. Craniofacial development is a complex process mediated by a variety of signaling molecules. In the future, the role of various signaling molecules in craniofacial development and malformations need to be explored to provide a new perspective and vision for the prevention and treatment of these craniofacial malformations.

18.
Article in Chinese | WPRIM | ID: wpr-942765

ABSTRACT

@#Dental and craniofacial bone development is a highly coordinated process that is tightly controlled by genetics and influenced by complex environments. The abnormal regulation of many development-related signaling molecules may lead to abnormal tooth development, severe craniofacial bone formation disorders, and developmental deformities. Transforming growth factor-β (TGF-β) is widely expressed in vivo and participates in many cellular biological processes, showing complex regulatory roles in mammalian craniofacial bone growth and tooth development. In tooth development, abnormal TGF-β signaling can lead to the failure of tooth germ formation, and its deletion mutation can directly affect odontoblast differentiation and enamel formation defects. However, the current research on TGF-β mainly focuses on the early stage of tooth development, and a comprehensive and systematic study of TGF-β-related tooth development is lacking. TGF-β signal transduction mainly controls the development of teeth and craniofacial bone by regulating the expression of development-related molecules via the classical Smad-dependent signaling pathway. In addition, the nonclassical mitogen-activated protein kinase (MAPK) pathway also participates in this process. Abnormal TGF-β signaling may cause jaw development disorders, temporomandibular joint dysplasia and inflammation, and cleft palate. Because the specific regulatory mechanism of TGF-β in craniofacial bone development has not been fully elucidated, its specific application in the treatment of related diseases is also greatly limited. This paper describes the new research progress of TGF-β in the development of teeth, jaws, temporomandibular joints and palate as well as related diseases.

19.
Rev. ABENO ; 21(1): 1544, dez. 2021. ilus
Article in English | LILACS, BBO | ID: biblio-1370622

ABSTRACT

Almost 30% of oral cleftsare associated with other structural abnormalities.However, little is known on orofacial characteristics related tothese cases since they are not systematically reported. To close this gap, we developed a collaborative learning approach supported by an interprofessional team aiming to systematicallydescribe oral findings and impactthe training of future professionals that hopefully will incorporate these descriptionsintotheir clinical practice. The methodological proposal consisted of small group sessions focusing on a particular syndrome or group of syndromes followed by examiningpatients with those conditions. Twenty cases were examined and studied over one semester andaset of conditions to be identified in the orofacial regionwasdefined. Here, we present a guideline that we suggest that dentists and dental institutions use. We also present the advantages of using collaborative learning as a tool in the training of the clinician (AU).


Quase 30% das fissuras orais estão associadas a outras anormalidades estruturais. No entanto, pouco se sabe sobre as características orofaciais relacionadas a esses casos, uma vez que não são relatados de forma sistemática. Para fechar essa lacuna, desenvolvemos uma abordagem de aprendizagem colaborativa apoiada por uma equipe interprofissional com o objetivo de descrever sistematicamente os achados orais e impactar o treinamento de futuros profissionais que, esperançosamente, irão incorporar essas descrições em sua prática clínica. A proposta metodológica consistia em sessões de pequenos grupos enfocando uma determinada síndrome ou grupo de síndromes seguidas de exame de pacientes com essas condições. Vinte casos foram examinados e estudados ao longo de um semestre e foi definido um conjunto de condições a serem identificadas na região orofacial. Aqui, apresentamos uma diretriz que sugerimos que os dentistas e instituições odontológicas utilizem. Também apresentamos as vantagens de usar a aprendizagem colaborativa como uma ferramenta no treinamento do clínico (AU).


Subject(s)
Humans , Orofaciodigital Syndromes/pathology , Cleft Palate/diagnosis , Craniofacial Abnormalities/pathology , Dentists , Education, Dental/methods , Interdisciplinary Placement/methods , Cleft Lip/pathology , Focus Groups/methods , Qualitative Research , Learning
20.
CES odontol ; 34(2): 61-75, jul.-dic. 2021. tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1374780

ABSTRACT

Resumen Introducción y Objetivo: La saliva cumple una importante función en la homeostasis oral, aunque no es evaluada rutinariamente en pacientes con labio con/sin paladar hendido (LH±PH). Este estudio pretendió comparar las características salivares de niños con LH±PH no sindrómico vs. niños sin esta diferencia craneofacial. Materiales y métodos: Se incluyeron 17 niños con LH±PH no sindrómico y 25 niños sin LH±PH, de los cuales se colectaron muestras de saliva estimulada (SE) y no estimulada (SNE). Se realizaron pruebas fisicoquímicas, cuantificación de iones (Ca, Mg y P), proteína total y recuento de streptococcus mutans en ambos grupos para ambas muestras de saliva. Para establecer comparaciones entre grupos se realizó la prueba no paramétrica de Mann-Whitney. Resultados: Hubo diferencias estadísticamente significativas en el pH de SE y SNE, así como en proteína total y capacidad amortiguadora de SNE. El pH (p=0,002) y capacidad amortiguadora (p=0,023) de SNE de los niños con LH±PH fueron menores, mientras que la concentración de proteína total (p=0,003) fue mayor con respecto al grupo control. Se encontró mayor proporción de estreptococo mutans en SNE de niños con LH±PH (6,39x104 UFC mL-1) respecto al grupo control (2,21x104 UFC mL-1), aunque sin detectar diferencias estadísticamente significativas (p=0,243). Conclusiones: Estos hallazgos sugieren una alteración en la función y composición de la SNE en pacientes con LH±PH no sindrómico, que correspondería a una alteración en la formación y función de las glándulas salivales en estos individuos que requiere ser investigada.


Abstract Introduction and objective: Saliva plays an important role in oral homeostasis, although it is not routinely evaluated in patients with CL±P. This study aimed to compare these characteristics in children with non-syndromic CL±P vs. children without this craniofacial difference. Materials and methods: This descriptive study included 17 children with non-syndromic CL±P from Fundación Clínica Noel and 25 children without CL±P. Stimulated (SS) and non-stimulated saliva (NSS) from both groups were collected for physicochemical tests, quantification of ions (Ca, Mg and P), total protein and streptococcus mutans count. Results: There were statistically significant differences in pH of SS and NSS, as well as in total protein concentration and buffer capacity in NSS. The pH (p = 0.002) and buffering capacity (p = 0.023) of NSS of CL±P children decreased, while total protein concentration (p = 0.003) increased compared to the control group. A higher streptococcus mutans count was found in NSS of CL±P children (6.39x104 CFU UFC mL-1) compared to the control group (2.21x104 UFC mL-1), although without detecting statistically significant differences (p = 0.243). Conclusions: These findings suggest an alteration in the function and composition of NSS in patients with non-syndromic CL±P; which could possibly be explained from the genetic/biological point of view by an alteration in the salivary glands formation and function in these individuals that requires further investigation.


Resumo Introdução e objetivo: A saliva desempenha um papel fundamental na homeostase oral, não é avaliada rotineiramente em pacientes com FL/P. Portanto, este estudo objetivou indagar essas características em crianças com FL/P não sindrômico. Materiais e métodos: 17 crianças com FL/P não sindrômico da Fundación Clínica Noel, e 25 crianças sem FL/P foram incluídas neste estudo. Amostras de saliva estimulada (SE) e saliva não estimulada (SNE) foram coletadas para realização de testes físico-químicos, quantificação de íons (Ca, Mg e P), proteína total e contagem de streptococcus mutans. Resultados: Houve diferenças estatisticamente significativas no pH de SE e SNE, bem como na concentração de proteína total e capacidade tampão de SNE. O pH (p=0,002) e a capacidade tampão (p=0,023) de SNE de crianças com FL/P foram menores, enquanto a concentração de proteína total (p=0,003) foi maior, quando comparado ao grupo controle. Um contagem maior de streptococcus mutans foi encontrada na saliva não estimulada de crianças com FL/P (6,39x104 UFC mL-1) em comparação ao grupo controle (2,21x104 UFC mL-1), embora sem detectar diferenças estatisticamente significativas (p=0,243). Conclusão: Esses achados sugerem uma alteração na função e composição da SNE em pacientes com FL/P não sindrômico; isso possivelmente poderia ser explicado do ponto de vista genético/biológico por uma alteração na formação e função das glândulas salivares nesses indivíduos que requer investigação.

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