ABSTRACT
The trajectory of healthcare has evolved from ancient holistic practices to the present biomedical model, reflecting the dynamic interplay between scientific progress, technological advancements, and the integration of humanistic values. While biomedical advancements have revolutionized medical treatments, there is an emerging recognition of the importance of integrating neuroscience and humanities to foster holistic patient care and understanding. This paper aims to explore the historical development of medicine, emphasizing the convergence of neuroscience, psychiatry, and neurology within the biomedical framework. Additionally, it investigates the resurgence of humanities in healthcare and its role in promoting patientcentered care. Through a comprehensive review of literature, this study traces the historical roots of medicine and examines the interdisciplinary intersections of neuroscience, psychiatry, neurology, and medical humanities. The exploration reveals the significant contributions of interdisciplinary approaches in enhancing patient-centered care, fostering a comprehensive understanding of health and well-being, and shaping modern healthcare practices. The integration of neuroscience and humanities offers valuable insights into the complexities of human health, bridging legacy practices with innovative approaches. Embracing this interdisciplinary perspective is crucial for promoting holistic healthcare, emphasizing patient-centered care, and enriching the understanding of health and well-being in contemporary healthcare settings.
A trajetória dos cuidados de saúde evoluiu das antigas práticas holísticas para o atual modelo biomédico, reflectindo a interação dinâmica entre o progresso científico, os avanços tecnológicos e a integração de valores humanísticos. Embora os avanços biomédicos tenham revolucionado os tratamentos médicos, há um reconhecimento emergente da importância de integrar as neurociências e as humanidades para promover a compreensão e os cuidados holísticos dos doentes. Este artigo tem como objetivo explorar o desenvolvimento histórico da medicina, salientando a convergência da neurociência, da psiquiatria e da neurologia no quadro biomédico. Além disso, investiga o ressurgimento das humanidades nos cuidados de saúde e o seu papel na promoção de cuidados centrados no doente. Através de uma revisão exaustiva da literatura, este estudo traça as raízes históricas da medicina e examina as intersecções interdisciplinares da neurociência, psiquiatria, neurologia e humanidades médicas. A exploração revela os contributos significativos das abordagens interdisciplinares para melhorar os cuidados centrados no doente, promover uma compreensão abrangente da saúde e do bem-estar e moldar as práticas modernas de cuidados de saúde. A integração das neurociências e das humanidades oferece conhecimentos valiosos sobre as complexidades da saúde humana, fazendo a ponte entre práticas antigas e abordagens inovadoras. A adoção desta perspetiva interdisciplinar é crucial para promover cuidados de saúde holísticos, enfatizando os cuidados centrados no doente e enriquecendo a compreensão da saúde e do bem-estar nos contextos de cuidados de saúde contemporâneos.
ABSTRACT
Functional near infrared spectroscopy (fNIRS) is an emerging neuroimaging tool that reflects the activity and function of brain neurons by monitoring changes in brain oxygen metabolism based on the neurovascular coupling mechanism. It is non-invasive and convenient, especially suitable for monitoring neonatal brain function. This article provides a comprehensive review of research related to the developmental patterns of brain networks concerning language, music, and emotions in neonates using fNIRS. It also covers brain network imaging in neonatal care, resting-state brain network connectivity patterns, and characteristics of brain functional imaging in disease states of neonates using fNIRS.
Subject(s)
Infant, Newborn , Humans , Spectroscopy, Near-Infrared , Brain/diagnostic imaging , Emotions , Language , TechnologyABSTRACT
Non-human primates(NHP)are becoming increasingly important laboratory animals,especially in the field of neuroscience,where many significant breakthroughs have been made,including research on brain development,neurodegenerative diseases,and psychiatric disorders.However,as their breeding and use grows,biosafety and animal ethics issues should be considered.This review summarizes the application and challenges of NHP laboratory animals in the neuroscience field from the aspects of an NHP overview,feeding and operation,biosafety,and animal ethics.
ABSTRACT
O presente artigo pretende apresentar a relação entre afetividade e cognição nas perspectivas teóricas de Jean Piaget, da neurociência e de Lev Vygotsky. Na perspectiva teórica de Piaget, confere ênfase aos conceitos de interesse e assimilação. Já na perspectiva teórica da neurociência, a ênfase é colocada nas bases biológicas da aprendizagem. Ademais, problematiza o lugar da perspectiva histórico-cultural de Vygotsky, enfatizando os conceitos de significado e sentido no contexto conceitual da relação entre afeto e cognição. A partir do recorte feito, apresenta algumas possíveis contribuições de tais leituras dentro do tema trabalhado concernentes à relação entre afeto e cognição. Argumenta ainda que embora comportem diferenças, as três perspectivas explicitam a importância do afeto para a cognição. Nessa direção, conclui pela relevância das contribuições dadas pelas leituras de Piaget, Vygotsky e da neurociência. As fontes utilizadas são da literatura disponível sobre o tema.
En el presente artículo se pretende presentar la relación entre afectividad y cognición en las perspectivas teóricas de Jean Piaget, de la neurociencia y de Lev Vygotsky. En la perspectiva teórica de Piaget, confiere énfasis a los conceptos de interés y asimilación. En la perspectiva teórica de la neurociencia, el énfasis está colocado en las bases biológicas del aprendizaje. Además, problematiza el lugar de la perspectiva histórico-cultural de Vygotsky, enfatizando los conceptos de significado y sentido en el contexto conceptual de la relación entre afecto y cognición. A partir del recorte, presenta algunas posibles contribuciones de tales lecturas dentro del tema estudiado concernientes a la relación entre afecto y cognición. Argumenta que, aunque comporten diferencias, las tres perspectivas explicitan la importancia del afecto para la cognición. En esa dirección, se concluye por la relevancia de las contribuciones dadas por las lecturas de Piaget, Vygotsky y de la neurociencia. Las fuentes utilizadas son de la literatura disponible sobre el tema.
This article aims to present the relation between affection and cognition from the Jean Piaget, neuroscience and Lev Vygotsky's theoretical perspectives. From Piaget's theoretical perspective, it emphasizes the concepts of interest and assimilation. From the neuroscience theoretical perspective, emphasis is placed on the biological bases of learning. Furthermore, it problematizes the place of Vygotsky's historical-cultural perspective, emphasizing the concepts of meaning and sense in the conceptual context of the relation between affection and cognition. Based on the selection made, it presents some possible contributions of such readings within the theme discussed regarding the relation between affect and cognition. It also argues that although they have differences, the three perspectives explain the importance of affect for cognition. In this direction, it concludes that the contributions made by reading Piaget, Vygotsky and neuroscience are relevant. The sources used are from the available literature about the topic.
Subject(s)
Neurosciences , Cognition , AffectABSTRACT
This narrative review addresses the intersection between neuroculture and aesthetics, exploring the intricate relationship between neuroscience and the perception of beauty. The presentation begins by mentioning the philosophical foundations of aesthetics and moves on to the neural basis behind the sensory and emotional processing of beauty. Progressing further, it presents the intricate networks involved in interactions and responses to art, elucidating the brain's mechanisms for appreciating artistic stimuli. Finally, it investigates the neural networks associated with deriving personal and symbolic meaning from art forms, shedding light on how our brains deduce meaning and value from aesthetic experiences. Thus, there is an integration of studies based on the connectome with neuroaesthetics, on how the complete network of neural connections in the brain influences and shapes the way we perceive, interpret, and appreciate beauty. Furthermore, the article addresses the impact of virtual reality and artificial intelligence on traditional concepts of creativity, challenging existing paradigms. Concluding, it explores the potential educational and therapeutic applications of 'Visual Thinking Strategies' in promoting artistic engagement with potential educational and therapeutic applications.
Esta revisão narrativa aborda a intersecção entre neurocultura e estética, explorando a intrincada relação entre neurociência e a percepção da beleza. A apresentação começa mencionando os fundamentos filosóficos da estética e avança para a base neural por trás do processamento sensorial e emocional da beleza. Progredindo ainda mais, apresenta as intrincadas redes envolvidas nas interações e respostas à arte, elucidando os mecanismos do cérebro para apreciar estímulos artísticos. Por fim, investiga as redes neurais associadas à obtenção de significado pessoal e simbólico das formas de arte, esclarecendo como nossos cérebros deduzem significado e valor de experiências estéticas. Assim, há uma integração de estudos baseados no conectoma com a neuroestética, sobre como a rede completa de conexões neurais cerebrais influencia e molda a maneira como percebemos, interpretamos e apreciamos a beleza. Além disso, o artigo aborda o impacto da realidade virtual e da inteligência artificial nos conceitos tradicionais de criatividade, desafiando os paradigmas existentes. Concluindo, explora as potenciais aplicações educativas e terapêuticas das 'Estratégias de Pensamento Visual' na promoção do envolvimento artístico com potenciais aplicações educativas e terapêuticas.
ABSTRACT
Introducción: La neurociencia desempeña un papel crucial en el desarrollo educativo, abarcando desde la etapa preescolar hasta la universitaria, al proporcionar conocimientos que enriquecen la cultura y los valores humanos. Objetivo: El grupo GME-CZH desarrolló un proyecto de proyección social centrado en la niñez y adolescencia y la enseñanza de neurociencias. El objetivo principal fue estimular el desarrollo cognitivo de niños y adolescentes a través de métodos innovadores, como juegos, charlas, Rally cerebral, etc., con el fin de reactivar sus mentes y enseñarles sobre el funcionamiento del cerebro. Materiales y Métodos: El proyecto se dividió en dos fases. La primera, "Semana del Cerebro 2018", se enfocó en niños y adolescentes de educación primaria y preuniversitaria, implementando actividades para estimular su interés en temas cerebrales. La segunda fase consistió en la colaboración de 150 niños y adolescentes (7-17 años) y expertos en neurociencias para la creación del libro "100 Preguntas que hacen los niños sobre el Cerebro". Resultados: La colaboración entre niños y expertos culminó en la creación exitosa del libro, abordando las inquietudes y preguntas planteadas por los niños sobre el cerebro y su funcionamiento. Conclusión: El proyecto demostró que la integración de métodos lúdicos y educativos puede ser efectiva para estimular el interés y desarrollo cognitivo en niños y adolescentes, destacando la importancia de la enseñanza de neurociencias en estas etapas educativas. Este proyecto innovador no solo contribuye al avance educativo, sino que también promueve el entendimiento del cerebro desde edades tempranas, fomentando el desarrollo integral de los estudiantes.
Introduction: Neuroscience plays a crucial role in educational development, spanning from preschool to university, providing knowledge that enriches culture and human values. Objective: The GME-CZH group developed a social outreach project focused on childhood and adolescence, specifically in the teaching of neuroscience. The main objective was to stimulate the cognitive development of children and adolescents through innovative methods such as games, talks, Brain Rally, etc., aiming to reinvigorate their minds and educate them about the functioning of the brain. Materials and Methods: The project was divided into two phases. The first, "Brain Week 2018," focused on primary and pre-university children and adolescents, implementing activities to stimulate their interest in brain-related topics. The second phase involved the collaboration of 150 children and adolescents (7-17 years old) and neuroscience experts for the creation of the book "100 Questions Children Ask About the Brain." Results: The collaboration between children and experts culminated in the successful creation of the book, addressing the concerns and questions posed by children about the brain and its functioning. Conclusion: The project demonstrated that the integration of playful and educational methods can be effective in stimulating interest and cognitive development in children and adolescents, emphasizing the importance of teaching neuroscience in these educational stages. This innovative project not only contributes to educational advancement but also promotes understanding of the brain from an early age, fostering the comprehensive development of students.
Subject(s)
Adolescent , Cerebrum , Neurosciences , Child , AdolescentABSTRACT
Abstract The breakdown of German psychiatry with the coming to power of the National Socialist regime in 1933 resulted in a revival after the war of bioethical issues, the immediate effect of which was the enactment of the Nuremberg Code. In many ways, this breakdown was the result of the historical evolution of psychomedical knowledge and the mass dissemination of reductionist discourses and ideas that created a breeding ground for tragedy. The cyclical discourse of psychic materialism, which has been repeated for centuries in the history of science in different formulations, can, if not properly interpreted, lead to far-reaching appropriations and risks, to which due attention must be paid. The latest manifestation of this issue, the view of mental life as basically cerebral, neurological, biochemical, and determinist, a view that has not been managed or presented adequately to the public, could become the basis for perverse new perspectives and applications in the current context of research and academic activity.
Resumen La llamada "quiebra" de la psiquiatría alemana en 1933, tras la llegada al poder del régimen nacionalsocialista, tuvo como resultado una reactivación de la cuestión bioética, cuyo efecto inmediato fue la promulgación del famoso Código de Nuremberg. En más de un sentido, tal ruptura fue el resultado del devenir histórico del conocimiento psicomédico, así como de la difusión masiva de discursos e ideas reduccionistas que terminaron por generar un caldo de cultivo propicio para la tragedia. El discurso cíclico del materialismo psíquico, que se reedita en la historia de la ciencia, en diferentes formatos y formulaciones, desde hace siglos, no bien interpretado, puede inducir apropiaciones y riesgos de largo alcance a los que se debe prestar la debida atención. Así, el último episodio de este asunto, la visión de la vida mental como vida básicamente cerebral, neurológica, bioquímica y determinista, no bien gestionado y presentado a la opinión pública, aunado a las condiciones actuales de la actividad investigadora y académica, podría convertirse en piedra angular de nuevas perspectivas y aplicaciones perversas de este asunto.
ABSTRACT
El presente artículo es una reseña biográfica de la vida del Dr. Christofredo Jakob, desde su formación en Alemania, las personalidades que acompañaron su desarrollo y las publicaciones científicas en suelo germano. Luego llegarían los inicios de su trabajo en la Argentina y los principales alcances de sus investigaciones. A través de esta reseña recorremos los comienzos del estudio sistemático del sistema nervioso en el país y recordamos el Día del Neurocientífico argentino. (AU)
This article is a biographical review of the life of Dr. Christofredo Jakob, from his training in Germany, the personalities who accompanied his development and the scientific publications on German soil. Then came the beginnings of his work in Argentina and the main achievements of his research. Through this review, we retrace the beginnings of the systematic study of the nervous system in the country and we remember the Day of the Argentine Neuroscientist. (AU)
Subject(s)
History, 19th Century , History, 20th Century , Physicians/history , Neurobiology , Neurosciences , Argentina , Biomedical Research , GermanyABSTRACT
@#At present, implant surgery robots have basically achieved "surgical intelligence", but "brain-inspired intelligence" of robots is still in the stage of theory and exploration. The formulation of a clinical implantation plan depends on the timing of implantation, implantation area, bone condition, surgical procedure, patient factors, etc., which need to evaluate the corresponding clinical decision indicators and clinical pathways. Inspired by evidence-based medicine and the potential of big data and deep learning, combined with the data characteristics of clinical decision indicators and clinical pathways that can be quantitatively or qualitatively analyzed, this review simulates the cognitive behavior and neural mechanisms of the human brain and proposes a feasible brain-inspired intelligence scheme by predicting the decision indices and executing clinical pathways intelligently, that is, "select clinical indicators and clarify clinical pathways -- construct database -- use deep learning to intelligently predict decision indicators -- intelligent execution of clinical pathways -- brain-inspired intelligence of implant decision-making". Combined with the previous research results of our team, this review also describes the process of realization of brain-inspired intelligence for immediate implant timing decisions, providing an example of the comprehensive realization of brain-inspired intelligence of implant surgery robots in the future. In the future, how to excavate and summarize other clinical decision factors and select the best way to realize the automatic prediction of evidence-based clinical indicators and pathways and finally realize the complete intellectualization of clinical diagnosis and treatment processes will be one of the directions that dental clinicians need to strive for.
ABSTRACT
Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed neuroinformatics.Data mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative diseases.Importantly,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain profile.In this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple sclerosis.We then discuss multi-omics integration approaches,including independent biological integration and unsupervised integra-tion methods,for more intuitive and informative interpretation of the biological data obtained across different omics layers.We further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain networks.Finally,we recommend a combination of high dimensional bio-informatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease mechanisms.We conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personalized medicine.
ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy, characterized by late diagnosis, aggressive growth, and therapy resistance, leading to a poor overall prognosis. Emerging evidence shows that the peripheral nerve is an important non-tumor component in the tumor microenvironment that regulates tumor growth and immune escape. The crosstalk between the neuronal system and PDAC has become a hot research topic that may provide novel mechanisms underlying tumor progression and further uncover promising therapeutic targets. In this review, we highlight the mechanisms of perineural invasion and the role of various types of tumor innervation in the progression of PDAC, summarize the potential signaling pathways modulating the neuronal-cancer interaction, and discuss the current and future therapeutic possibilities for this condition.
Subject(s)
Humans , Carcinoma, Pancreatic Ductal/pathology , Pancreatic Neoplasms/therapy , Signal Transduction , Peripheral Nerves/metabolism , Tumor MicroenvironmentABSTRACT
Objective: Changes in the kynurenine pathway are recognized in psychiatric disorders, but their role in Alzheimer's disease (AD) is less clear. We aimed to conduct a systematic review and meta-analysis to determine whether tryptophan and kynurenine pathway metabolites are altered in AD. Methods: We performed a systematic review and random-effects meta-analyses. Inclusion criteria were studies that compared AD and cognitively normal (CN) groups and assessed tryptophan or kynurenine pathway metabolites in cerebrospinal fluid or peripheral blood. Results: Twenty-two studies with a total of 1,356 participants (664 with AD and 692 CN individuals) were included. Tryptophan was decreased only in peripheral blood. The kynurenine-to-tryptophan ratio was only increased in peripheral blood of the AD group. 3-Hydroxykynurenine was decreased only in cerebrospinal fluid and showed higher variability in the CN group than the AD group. Kynurenic acid was increased in cerebrospinal fluid and decreased in peripheral blood. Finally, there were no changes in kynurenine and quinolinic acid between the groups. Conclusions: Our results suggested a shift toward the kynurenine pathway in both the brain and in the periphery, as well as a shift towards increased kynurenic acid production in the brain but decreased production in peripheral blood. In addition, our analysis indicated dissociation between the central and peripheral levels, as well as between plasma and serum for some of these metabolites. Finally, changes in the kynurenine pathway are suggested to be a core component of AD. More studies are warranted to verify and consolidate our results.
ABSTRACT
Chemotherapy is one of the most widely used treatments for breast cancer (BC). However, there is evidence of side effects like cognitive changes related to the chemotherapy treatment. The aim of the study was not only to summarize the existing evidence on the relationship between chemotherapy and cognitive performance in women with BC but also to identify additional consequences and aspects associated with these impairments. We conducted a systematic review with meta-analysis and meta-regression to present updated information on the matter. We retrieved data from the databases PubMed, Web of Science, PsycINFO, CINAHL, and Scopus. Twenty studies comprising over 2,500 women were examined and the results indicated that chemotherapy can compromise cognition in women with BC (-1.10 OR [95%CI: -1.81 to -0.74], P<0.01), with working memory (-0.49 OR [95%CI: -0.85 to -0.13], P=0.03) being the most affected among the domains. Furthermore, additional data indicated that cognitive impairment is most likely amid women with BC having a lower education level (Q=4.85, P=0.02). Our results suggested that chemotherapy affects cognitive functions in women with BC, and certain characteristics can worsen the deterioration. A comprehensive study of women with breast cancer and existing predictors contributes to optimized personal journeys, elevated life prospects, and advanced care that can also aid prognosis and therapeutic approaches.
ABSTRACT
Resumo A percepção do papel do trauma psicológico na origem de problemas psiquiátricos aumentou e diminuiu ao longo da história da psiquiatria. Com a concepção do transtorno de estresse pós-traumático (TEPT), entretanto, as sociedades ocidentais presenciaram uma profunda expansão do discurso do traumatismo na interpretação de experiências humanas devastadoras, como catástrofes, genocídios, desastres e epidemias. A partir de revisão bibliográfica integrativa, este artigo analisa alguns dos determinantes históricos e epistemológicos que fundamentam o surgimento da memória traumática e o estabelecimento do trauma como campo semântico que orienta respostas clínicas e estratégias políticas no campo das ciências humanas e da saúde.
Abstract Perceptions of the importance of the role of psychological trauma in the origins of psychiatric problems have oscillated throughout the history of psychiatry. However, since the conception of post-traumatic stress disorder (PTSD), western societies have witnessed a marked expansion of the discourse of trauma in the interpretation of devastating human experiences like catastrophes, genocides, disasters, and epidemics. Through an integrative literature review, this article analyzes some of the historical and epistemological determinants behind the emergence of traumatic memory and the establishment of trauma as a semantic field that orients clinical responses and political strategies in the field of the humanities and the health sciences.
Subject(s)
Stress Disorders, Post-Traumatic , Stress, Psychological , Wounds and Injuries/history , NeurosciencesABSTRACT
Metacognition, or 'knowledge and cognition about cognitive phenomena’ is our human ability to think about the way we think and learn. By engaging in metacognition, human beings can actively manage and regulate what we do before, during and after the process or action. Although metacognitive awareness is a hidden psychological construct, it manifests itself in three ways, i.e. (i) metacognitive knowledge, (ii) metacognitive experience, and (iii) strategy use. Metacognitive knowledge includes person's knowledge, task knowledge as well as strategy knowledge. Strategy use includes language learning and language use. Metacognitive knowledge is an indicative knowledge about how one is thinking and learning can be positively or negatively influenced by internal factors such as personality traits, background strategic processes, as well as external factors such as the nature and demand of learning and communication tasks. This article focusses on how neuroscientific developments can inform teaching practice
ABSTRACT
La actividad cerebral tiene múltiples atributos, entre ellos los eléctricos, metabólicos, hemodinámicos y hormonales. Los métodos modernos para estudiar las funciones cerebrales como el PET (Tomografía por Emisión de Positrones), fMRI (Imagen de Resonancia Magnética Funcional) y MEG (Magnetoencefalograma) son ampliamente utilizados por los científicos. Sin embargo, el EEG es una herramienta utilizada para la investigación y diagnóstico debido a su bajo costo, simplicidad de uso, movilidad y la posibilidad de monitoreo a largo tiempo de adquisición. Para detectar e interpretar las características relevantes de estas señales, se describe cada proceso por su escala temporal (EEG) y espacial (fMRI). La presente investigación se enfoca en realizar una revisión bibliográfica sobre la integración de datos multimodales EEG-fMRI que propicie valorar su importancia para el desarrollo de algoritmos de fusión y su uso en el contexto cubano. Para ello se analizaron documentos con altos índices de citas en la literatura, donde se destacan autores precursores de los temas en análisis. Los estudios multimodales EEG-fMRI generan múltiples datos temporales y espaciales con alto valor para la medicina basada en evidencia. La integración de los mismos provee un valor agregado en la búsqueda de nuevos métodos diagnósticos, aplicando minería de datos, Deep learning y algoritmos de fusión. En este trabajo se pone de relieve la existencia de baja resolución temporal de fMRI y por otro lado la baja resolución espacial de EEG, por lo que la integración de ambos estudios aumentaría la calidad de su información(AU)
Brain activity has multiple attributes, including electrical, metabolic, hemodynamic, and hormonal. Modern methods for studying brain functions such as PET (Positron Emission Tomography), fMRI (Functional Magnetic Resonance Imaging), and MEG (Magnetoencephalogram) are widely used by scientists. However, the EEG is a tool used for research and diagnosis due to its low cost, simplicity of use, mobility and the possibility of long-term monitoring of acquisition. To detect and interpret the relevant characteristics of these signals, each process is described by its temporal (EEG) and spatial (fMRI) scale. The present research focuses on conducting a bibliographic review on the integration of multimodal EEG-fMRI data that favors assessing its importance for the development of fusion algorithms and their use in the Cuban context. For this, documents with high rates of citations in the literature were analyzed, where precursor authors of the topics under analysis stand out. Multimodal EEG-fMRI studies generate multiple temporal and spatial data with high value for evidence-based medicine. Their integration provides added value in the search for new diagnostic methods, applying data mining, Deep learning and fusion algorithms. This work highlights the existence of low temporal resolution of fMRI and, on the other hand, the low spatial resolution of EEG, so the integration of both studies would increase the quality of their information(AU)
Subject(s)
Humans , Male , Female , Medical Informatics Applications , Neurosciences , Electroencephalography/methods , Multimodal Imaging/methodsABSTRACT
Para los neurocientíficos constituye un desafío realizar un seguimiento de los datos y metadatos generados en cada investigación y extraer con precisión toda la información relevante, hecho crucial para interpretar resultados y requisito mínimo para que los investigadores construyan sus investigaciones sobre los hallazgos anteriores. Se debe mantener tanta información como sea posible desde el inicio, incluso si esta pudiera parece ser irrelevante, además de registrar y almacenar los datos con sus metadatos de forma clara y concisa. Un análisis preliminar sobre la literatura especializada arrojó ausencia de una investigación detallada sobre cómo incorporar la gestión de datos y metadatos en las investigaciones clínicas del cerebro, en términos de organizar datos y metadatos completamente en repositorios digitales, recopilar e ingresar estos teniendo en cuenta su completitud, y sacar provecho de dicha recopilación en el proceso de análisis de los datos. Esta investigación tiene como objetivo caracterizar conceptual y técnicamente los datos y metadatos de neurociencias para facilitar el desarrollo de soluciones informáticas para su gestión y procesamiento. Se consultaron diferentes fuentes bibliográficas, así como bases de datos y repositorios tales como: Pubmed, Scielo, Nature, Researchgate, entre otros. El análisis sobre la recopilación, organización, procesamiento y almacenamiento de los datos y metadatos de neurociencias para cada técnica de adquisición de datos (EEG, iEEG, MEG, PET), así como su vínculo a la estructura de datos de imágenes cerebrales (BIDS) permitió obtener una caracterización general de cómo gestionar y procesar la información contenida en los mismos(AU)
For neuroscientists, it is a challenge to keep track of the data and metadata generated in each investigation and accurately extract all the relevant information, a crucial fact to interpret results and a minimum requirement for researchers to build their investigations on previous findings. Keep as much information as possible from the start, even if it may seem irrelevant and record and store the data with its metadata clearly and concisely. A preliminary analysis of the specialized literature revealed an absence of detailed research on how to incorporate data and metadata management in clinical brain research, in terms of organizing data and metadata completely in digital repositories, collecting and inputting them taking into account their completeness. , and take advantage of such collection in the process of data analysis. This research aims to conceptually and technically characterize neuroscience data and metadata to facilitate the development of computer solutions for its management and processing. Different bibliographic sources were consulted, as well as databases and repositories such as: Pubmed, Scielo, Nature, Researchgate, among others. The analysis on the collection, organization, processing and storage of neuroscience data and metadata for each data acquisition technique (EEG, iEEG, MEG, PET), as well as its link to the brain imaging data structure (BIDS) allowed to obtain a general characterization of how to manage and process the information contained in them(AU)
Subject(s)
Humans , Male , Female , Medical Informatics , Medical Informatics Applications , Programming Languages , Information Storage and Retrieval/methods , Metadata , NeurosciencesABSTRACT
Resumen: 1] La neurociencia de la ética constituye un progreso al aplicar la ciencia empírica en la investigación del fenómeno moral. 2] Resaltar la importancia de afectos y sentimientos representa una compensación a la excesiva importancia dada a la razón en la formación de los juicios morales. 3] Existen graves dificultades metodológicas al no precisar los conceptos de "intuición", "afectos", "deber" y especialmente qué se entiende por "ética". 4] Pero la investigación científica aprehende al hombre como una "entidad" en sí (presente) y no como una "existencia" (futuro), vale decir, ser-en-el-mundo. 5] En lugar de "tener" una moral el ser humano "es" moral y, como tal, es un proyecto lanzado hacia su más auténtica posibilidad que consiste en apropiarse de su ser-para-la-muerte.
Abstract: 1] The Neuroscience of Ethics constitutes a progress when applying empirical science in the investigation of the moral phenomenon. 2] Emphasizing the importance of affects and feelings represents a compensation for the excessive importance given to reason in the formation of moral judgments. 3] There are serious methodological difficulties by not specifying the concepts of intuition, affections, duty and especially what is understood by ethics. 4] But scientific research apprehends man as an "entity" in himself (present) and not as an "existence" (future), that is, being-in-the-world. 5] Instead of "having" a moral, the human being "is" moral and as such is a project thrown towards its most authentic possibility that consists of appropriating its being-for-death.
Resumo: 1] A neurociência da ética constitui um progresso ao aplicar a ciência empírica na investigação do fenômeno moral. 2] Ressaltar a importância de afetos e sentimentos representa uma compensação à excessiva importância dada à razão na formação dos juízos morais. 3] Existem graves dificuldades metodológicas ao não precisar os conceitos de "intuição", "afetos", "dever" e especialmente o que se entende por "ética". 4] Porém a investigação científica apreende o homem como uma "entidade" em si (presente) e não como una "existência" (futuro), vale dizer, ser-no-mundo. 5] Em lugar de "ter" uma moral o ser humano "é" moral e, como tal, é um projeto lançado à sua mais autêntica possibilidade, que consiste em apropriar-se de seu ser-para-a-morte.
Subject(s)
Humans , Bioethics/trends , Neurosciences/trends , Neurosciences/ethics , Intuition , Empirical Research , Ethics, Research , Emotions , MoralsABSTRACT
En el último medio siglo, la neurociencia ha sabido ganarse una posición hegemónica en el marco cultural y académico contemporáneo. En este artículo discutimos dos modelos para explicar al cerebro humano. Por un lado, existe el modelo de la neurociencia clásica, que es el modo de común con que se enseña neurociencia actualmente, suele dividir al cerebro en lóbulos o áreas. Por otro lado, el modelo inspirado en la Teoría Sociobiológica Informacional que considera al cerebro como un doble sistema de integración: paleocortical y neocortical, siendo este último (la conciencia) todo lo internalizado por una persona en el curso de una vida en sociedad. El objetivo de esta revisión es presentar estos dos modelos o enfoques (el "clásico" y el "sociobiológico informacional") para explicar al cerebro humano (por demás, uno de los grandes temas que cualquier enseñanza de la neurociencia está obligada a tocar).
In the last half-century, neuroscience has managed to gain a hegemonic position in the current cultural and academic framework. In this article, we discuss two models to explain the human brain. On the one hand, there is the classical neuroscience model, which is the common way in which neuroscience is currently taught, it usually divides the brain into lobes or areas. On the other hand, there is the sociobiological informational model that treats the brain as an integrated dual system: paleocortex and neocortex, the latter being (consciousness) what a person has internalized in the course of a life in society. The objective of this review is to present these two models or approaches (the "classical" and the "sociobiological informational") to explain the human brain (one of the great issues that any teaching of neuroscience is obliged to touch).
Subject(s)
HumansABSTRACT
This paper aim is to discuss and clarify about the way we perceived the functionality of the synapse since 4th century BC up to modern times and actual status. The discussions over the way synapses work began over 2400 years ago and it all started from the simple question of how the locomotive system works and how do the muscles contract. The rst who discussed about this concept was Plato during the 4th century BC. We are discussing about René Descartes (1596-1650) depiction of a clear view in the book entitled “De Homine” (1662) over the view of the brain and the innervation of the body. In modern times, the word “synapse” was coined for the rst time in Michael Foster's 7th Edition “Textbook of Physiology” of 1897 , for which Sherrington wrote 3 chapters. He proposed his former Professor to introduce the word “synapse” which comes from Greek and means “conjunction”. For this discovery, Charles Sherrington and Edgar Douglas Adrian were awarded the Nobel Prize in Physiology or Medicine in 1932.