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Article in Chinese | WPRIM | ID: wpr-953949


Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease with complex and diverse pathogenesis, and there is no effective treatment or specific drugs for its clinical treatment. In recent years, its incidence has been on the rise, and it has become the earnest expectation of medical researchers in China and abroad that related patients could be treated. AMP-activated protein kinase (AMPK) functions to regulate cellular energy homeostasis and mitochondrial homeostasis. When activated, it has a good intervention effect on NAFLD progression with lipid metabolism disorders and mitochondrial homeostasis disorders. For NAFLD, the activation of AMPK can inhibit the production of new lipogenesis in the liver, promote the oxidation of fatty acids in the liver, and enhance the mitochondrial function of adipose tissues. As a key target of metabolic diseases, AMPK can also improve apoptosis, liver fibrosis, autophagy, and inflammation. Traditional Chinese medicine (TCM) is good at treating diseases from multiple targets and multiple pathways and is also commonly used in the treatment of chronic liver disease in clinical practice. A large number of in vitro and in vivo experimental studies on NAFLD have shown that TCM monomers have good prospects for the treatment of NAFLD through the AMPK signaling pathway, including glycosides, phenols, alkaloids, flavonoids, quinones, terpenoids, and lignans, which are natural activators of AMPK. This study reviewed the research progress on TCM monomers in regulating the AMPK pathway to prevent and treat NAFLD, providing a broader perspective for TCM treatment of NAFLD.

Article in Chinese | WPRIM | ID: wpr-906194


Ovarian cancer is a kind of malignant tumor in female reproductive system with a high incidence. This disease is insidious at its early stage and the symptoms are not typical. Most of the patients have reached advanced stage by the time of diagnosis, seriously threating women's life and health. Many signaling pathways are involved in the formation and development of ovarian cancer, among which the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt) signaling pathway is one of the key regulatory pathways. In recent years, traditional Chinese medicine (TCM) has obtained wide attention in treatment of tumors due to its advantages of high safety and less adverse reactions, and more and more attention has been paid to the study of TCM monomers. Molecular biology studies have shown that TCM monomers can play a role against tumor by regulating multiple targets. By reviewing the literature and searching several databases, we found that TCM monomer can play an important role in the growth, proliferation, invasion and migration, apoptosis, autophagy and reversal of drug resistance of ovarian cancer cells by regulating PI3K/Akt signaling pathway. According to the existing studies, TCM monomers have a certain effect on ovarian cancer, but there are still many problems. Although the mechanisms of some TCM monomers have been clarified in the treatment of ovarian cancer, such TCM monomers are only limited to the tumor-bearing nude mice in vivo and experimental studies on in vitro cells, and further studies are needed in the future. In addition, in the future researches, ovarian cancer syndrome differentiation and targeted therapy can be linked to the TCM flavors, efficacy and indications to further develop the advantages of TCM. Based on the current research situation at home and abroad, this paper summarized the research progress of targeted intervention of TCM monomers in ovarian cancer by regulating PI3K/Akt signaling pathway, in order to provide reference for further research of TCM monomers, and provide important ideas for the development of targeted treatment of ovarian cancer with TCM.