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1.
Braz. j. biol ; 84: e253508, 2024. tab, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1360218

ABSTRACT

Present research work represents antiviral and antibacterial value of body fat of Saara hardwickii commonly called as spiny tailed lizard. Oil was extracted from body fats located in the ventral region of this animal using hydrocarbons e.g., n-hexane, methanol, butanol and ethyl acetate as a solvent. The antibacterial activity of lizard oil was tested against standard as well as multi-resistant lines ofEscherichia coli, Styphalococcus aureus, Pseudomonas aeruginosa and Proteus vulgaris alone and with antibiotic ampicillin. For antibacterial potential, Ethyl acetate and Butanol solvent extract showed best zone of inhibition (7mm) with P. aeruginosa and S. aureus respectively. For antiviral potential, Butanol and Methanol extract showed best HA (Hemagglutination) titer of 04 with NDV and IBV viral strain respectively. It is concluded that lizard oil has antimicrobial potential against different pathogens strains (virus, bacteria).


O presente trabalho de pesquisa apresenta a importância antiviral e antibacteriana da gordura corporal de Saara hardwickii, comumente chamado de lagarto de cauda espinhosa. O óleo foi extraído de gorduras corporais localizadas na região ventral desse animal usando hidrocarbonetos, por exemplo, n-hexano, metanol, butanol e acetato de etila, como solvente. A atividade antibacteriana do óleo do lagarto foi testada em linhagens padrão e multirresistentes de Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa e Proteus vulgaris, de forma isolada e com antibiótico ampicilina. Para o potencial antibacteriano, acetato de etila e extrato de butanol apresentaram melhor zona de inibição (7 mm) com P. aeruginosa e S. aureus, respectivamente. Para o potencial antiviral, o extrato de butanol e o extrato de metanol apresentaram melhor título de hemaglutinação de 4 com as cepas virais NDV e IBV, respectivamente. Conclui-se que o óleo do lagarto possui potencial antimicrobiano contra diferentes cepas de patógenos (vírus e bactérias).


Subject(s)
Animals , Antiviral Agents , Adipose Tissue , Lizards , Anti-Bacterial Agents
2.
Rev. bras. med. esporte ; 29(spe1): e2022_0190, 2023. tab
Article in English | LILACS | ID: biblio-1394851

ABSTRACT

ABSTRACT Introduction A healthy body depends on several factors, and physical exercise is one of the main factors. Research results on the physical health of female university students show that although the general health status of Chinese female students is good, the quality of physical performance at university continues to show a slow downward trend. Objective To explore the effects of different exercises on the fat mass and lean weight indices of female university students. Methods 60 female students who participated in aerobics and ball games training in the Physical Education Department of a university were randomly divided into a control group and a training group, with 30 volunteers in each group. The experimental group performed intensive aerobics training and ball training. In contrast, no intervention was performed in the control group, and indicators were collected and analyzed according to current literature. Results After eight weeks of the intervention protocol, the body weight, body fat weight, lean weight, body surface area, and body fat ratio of the control group had no significant changes from the period before the experiment (P > 0.05). In the training group, fat weight decreased significantly (p<0.01), lean mass weight increased significantly (p<0.01), body fat ratio decreased (p<0.01), and body weight and body surface area had no significant changes (p>0.05). PTH and FSH in the training group were significantly higher than in the control group (P < 0.05). As the aerobic exercise level improved in the experimental group, the weight and abdominal skinfold thickness in the exercise group showed a downward trend. Conclusion There is a general correlation between BMI and body fat content and its body distribution in college women. Compared to men, BMI is better suited to describe the fat metabolism of college women. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


RESUMO Introdução Um corpo saudável depende de vários fatores e o exercício físico é um dos principais. Os resultados de pesquisa na saúde física das estudantes universitárias mostram que apesar do estado de saúde geral das estudantes chinesas serem bons, a qualidade no desempenho físico na universidade continua a mostrar uma lenta tendência de queda. Objetivo Explorar os efeitos de distintos exercícios sobre os índices de gordura e massa magra de universitárias. Métodos 60 alunas que participaram de treinamento de aeróbica e jogos de bola no Departamento de Educação Física de uma universidade foram divididas aleatoriamente em grupo de controle e grupo de treinamento, com 30 voluntárias em cada grupo. O grupo experimental realizou treinamento intensivo de aeróbica e treinamento com bola, enquanto nenhuma intervenção foi executada no grupo controle, a coleta e análise dos indicadores foi executada segundo a literatura corrente. Resultados Após 8 semanas do protocolo de intervenção, o peso corporal, peso da gordura corporal, peso magro, área de superfície corporal e relação de gordura corporal do grupo controle não tiveram alterações significativas em relação ao período anterior ao experimento (P > 0,05). No grupo de treinamento, o peso da gordura diminuiu significativamente (p<0,01), o peso da massa magra aumentou significativamente (p<0,01), a relação de gordura corporal diminuiu (p<0,01), o peso corporal e a superfície corporal não sofreram alterações significativas (p>0,05). O PTH e FSH no grupo de treinamento foram significativamente maiores do que os do grupo controle (P < 0,05). Com a melhora do nível de exercício aeróbico no grupo experimental, o peso e a espessura da dobra cutânea abdominal no grupo de exercício apresentaram uma tendência de queda. Conclusão Há uma correlação geral entre o IMC e o teor de gordura corporal e a sua distribuição corporal em universitárias. Em comparação com os homens, o IMC é mais adequado para descrever o metabolismo de gordura de universitárias. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción Un cuerpo sano depende de varios factores y el ejercicio físico es uno de los principales. Los resultados de la investigación sobre la salud física de las estudiantes universitarias muestran que, aunque el estado de salud general de las estudiantes chinas es bueno, la calidad del rendimiento físico en la universidad sigue mostrando una lenta tendencia a la baja. Objetivo Explorar los efectos de diferentes ejercicios sobre los índices de grasa y peso magro de estudiantes universitarias. Métodos 60 alumnas que participaban en el entrenamiento de aeróbic y juegos de pelota en el Departamento de Educación Física de una universidad fueron divididas aleatoriamente en un grupo de control y un grupo de entrenamiento, con 30 voluntarias en cada grupo. El grupo experimental realizó un entrenamiento aeróbico intensivo y un entrenamiento con balón, mientras que en el grupo de control no se llevó a cabo ninguna intervención; la recogida y el análisis de los indicadores se realizaron de acuerdo con la literatura actual. Resultados Tras 8 semanas del protocolo de intervención, el peso corporal, el peso de la grasa corporal, el peso magro, la superficie corporal y la proporción de grasa corporal del grupo de control no presentaron cambios significativos en comparación con el periodo anterior al experimento (P > 0,05). En el grupo de entrenamiento, el peso de la grasa disminuyó significativamente (p<0,01), el peso de la masa magra aumentó significativamente (p<0,01), la proporción de grasa corporal disminuyó (p<0,01), el peso corporal y la superficie corporal no tuvieron cambios significativos (p>0,05). La PTH y la FSH en el grupo de entrenamiento fueron significativamente mayores que las del grupo de control (P < 0,05). Con la mejora del nivel de ejercicio aeróbico en el grupo experimental, el peso y el grosor del pliegue cutáneo abdominal en el grupo de ejercicio mostraron una tendencia a la baja. Conclusión Existe una correlación general entre el IMC y el contenido de grasa corporal y su distribución en las estudiantes universitarias. En comparación con los hombres, el IMC es más adecuado para describir el metabolismo de las grasas de las estudiantes universitarias. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.


Subject(s)
Humans , Female , Sports , Students , Body Mass Index , Adipose Tissue , Women's Health , Case-Control Studies
4.
MHSalud ; 19(2)dic. 2022.
Article in Spanish | LILACS-Express | LILACS, SaludCR | ID: biblio-1405530

ABSTRACT

Resumen Objetivo: Comparar la composición corporal por antropometría clásica e impedancia bioeléctrica en estudiantado universitario de una universidad peruana. Método: Estudio correlacional, transversal, conformado por 152 estudiantes (77 varones y 75 mujeres) matriculados en el ciclo 2018-II con edad promedio de 20.45 ± 3.63 años. Se calculó para el método de antropometría el índice de masa corporal, mediciones antropométricas y se utilizó la ecuación de Yuhasz (1974) para determinar el porcentaje de grasa corporal, y para el de bioimpedancia eléctrica se utilizó el analizador tetrapolar multifrecuencia de medición segmental directa Inbody 120. Para establecer la correlación se utilizó el coeficiente de Pearson y para la concordancia se utilizó el método gráfico de Bland Altman e índice de estabilidad. Los datos fueron analizados con el programa estadístico IBM SPSS Statistics, versión 27.0. Para todos los análisis se utilizó un nivel de significancia (p<0.05). Resultados: Existe una fuerte correlación estadísticamente significativa (p<0.01y r=0.95) entre los métodos de antropometría y bioimpedancia eléctrica para la determinación del porcentaje de grasa corporal; además, una buena concordancia según el método gráfico de Bland Altman, reforzada con el índice de estabilidad para complemento de la interpretación (IE= 95 %). Conclusiones: Ambos métodos son intercambiables entre sí, por lo que pueden ser usados indistintamente en este tipo de población para determinar el porcentaje de grasa corporal expresado en porcentaje.


Abstract Objective: The aim was to compare the body composition using classical anthropometry and bioelectric impedance in university students of a Peruvian university. Method: a correlational, cross-sectional study with a research sample of 152 students (77 men and 75 women) enrolled in the 2018-II period with an average age of 20.45 ± 3.63 years. The body mass index and anthropometric measurements were calculated for the anthropometric method. The Yuhasz (1974) equation was used to determine the body fat percentage. The electrical bioimpedance method implemented the tetrapolar multi-frequency direct segmental measurement analyzer Inbody 120. Pearson coefficient was used to establish the correlation, and the Bland Altman graphical method and stability index were used for concordance. The data were analyzed using the statistical software application IBM SPSS Statistics, version 27.0. A level of significance (p <0.05) was used for all analyzes. Results: there is a strong statistically significant correlation (p<0.01 and r = 0.95) between the anthropometric and electrical bioimpedance methods to determine body fat percentage. In addition, there is a good agreement according to the Bland Altman graphical method, reinforced by the stability index to complement the interpretation (IE = 95%). Conclusions: Both methods are interchangeable with each other, so they can be used indistinctly in this type of population to determine body fat percentage.


Resumo Objetivo: comparar a composição corporal por antropometria clássica e impedância bioelétrica em estudantes universitários de uma universidade peruana. Método: estudo correlacional, transversal, compreendendo 152 estudantes (77 homens e 75 mulheres) matriculados no ciclo 2018-II, com idade média de 20,45 ± 3,63 anos. Para o método antropométrico, o índice de massa corporal, as medidas antropométricas e a equação de Yuhasz (1974) foram calculados para determinar a porcentagem de gordura corporal; e para o método de bioimpedância elétrica foi usado o analisador tetrapolar multifrequencial com medida segmentar direta Inbody 120. O coeficiente de Pearson foi usado para estabelecer a correlação; o método gráfico Bland Altman e o índice de estabilidade foram usados para a concordância. Os dados foram analisados com o IBM SPSS Statistics, versão 27.0. Um nível de significância (p<0,05) foi usado para todas as análises. Resultados: há uma forte correlação estatística significativa (p<0,01 e r=0,95) entre os métodos de antropometria e bioimpedância elétrica para a determinação da porcentagem de gordura corporal; além disso, uma boa concordância de acordo com o método gráfico Bland Altman, reforçado com o índice de estabilidade para complementar a interpretação (IE= 95%). Conclusões: Ambos os métodos são intercambiáveis entre si, portanto, podem ser utilizados indistintamente nesse tipo de população para determinar a porcentagem de gordura corporal expressa como porcentagem.


Subject(s)
Humans , Male , Female , Adult , Anthropometry/instrumentation , Adipose Tissue , Electric Impedance/therapeutic use
5.
Int. j. cardiovasc. sci. (Impr.) ; 35(4): 530-536, July-Aug. 2022. tab, graf
Article in English | LILACS | ID: biblio-1385261

ABSTRACT

Abstract Background: Although electrical and structural remodeling has been recognized to be important in the pathophysiology of atrial fibrillation, the mechanisms underlying remodeling process are unknown. There has been increasing interest in the involvement of inflammatory molecules and adipokines released from the epicardial fat tissue in the pathophysiology of atrial fibrillation. Objectives: In our study, we aimed to investigate the relationship of atrial fibrillation with increased epicardial adipose tissue, inflammatory molecules released from this tissue and omentin. Methods: Thirty-six patients who were followed up with a diagnosis of permanent AF at the cardiology outpatient clinic 33 individuals without atrial fibrillation (controls) were included in the study. Epicardial adipose tissue thickness of patients was measured by echocardiography. Serum omentin, IL 6, IL 1 beta, TNF alpha and CRP levels were measured. Man-Whitney U test was performed for comparisons and significance was established at 5% (p<0.05). Results: Epicardial adipose tissue thickness was significantly greater in the patient group (6mm [4-5.5]) than controls (4mm [3-5.5]) (p <0.001). No significant difference was found in the concentrations of omentin or inflammatory molecules between the groups. Conclusion: No relationship was found between atrial fibrillation and serum levels or omentin or inflammatory markers. A relationship between epicardial adipose tissue thickness measured by echocardiography and atrial fibrillation was determined.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Pericardium/anatomy & histology , Atrial Fibrillation/physiopathology , Adipose Tissue , Echocardiography , Biomarkers , Adipokines/physiology
6.
Säo Paulo med. j ; 140(3): 384-389, May-June 2022. tab, graf
Article in English | LILACS | ID: biblio-1377397

ABSTRACT

ABSTRACT BACKGROUND: Acute ischemic stroke (AIS) is the most common type of stroke. Inflammation is the primary factor in the pathogenesis of atherosclerosis. Use of immature granulocytes (IGs) has been recommended as a new indicator of systemic inflammation. However, data on the association between echocardiographic epicardial fat tissue thickness (EFT) and IGs in patients with AIS are limited. OBJECTIVE: To evaluate the association between the presences of IGs, epicardial fat tissue and AIS. DESIGN AND SETTING: Prospective study in a tertiary-care university hospital in Antalya, Turkey. METHODS: Our study included 53 AIS patients and 41 healthy controls with age and gender compatibility. Blood samples and transthoracic echocardiography of all participants were compared. RESULTS: IG levels were significantly higher in patients with AIS than in controls (0.62 ± 0.36 versus 0.28 ± 0.02, P < 0.001). The mean EFT was 3.74 ± 0.61 mm in the control group and 6.33 ± 1.47 mm in the AIS patient group. EFT was significantly greater in AIS patients than in controls (P < 0.001). For the optimum cut-off value for IG (0.95), the area under the curve (AUC) was determined to be 0.840; sensitivity was determined to be 81.1% and specificity, 92.5%. For the optimum cut-off value for EFT (4.95 mm), the AUC was determined to be 0.953; sensitivity was determined to be 90.6% and specificity, 90%. CONCLUSIONS: IG and echocardiographic EFT are clinical markers that can be used to predict AIS risk.


Subject(s)
Humans , Ischemic Stroke , Echocardiography , Adipose Tissue/pathology , Adipose Tissue/diagnostic imaging , Prospective Studies , Risk Factors , Granulocytes , Inflammation
7.
Arch. latinoam. nutr ; 72(2): 100-108, jun. 2022. ilus
Article in Spanish | LILACS, LIVECS | ID: biblio-1381416

ABSTRACT

Las investigaciones realizadas durante el último siglo relacionadas con la descripción de la Microbiota Intestinal (MI) sugieren una relación concreta entre su composición y la salud del huésped. Su desregulación denominada disbiosis intestinal ha sido asociada a distintos tipos de enfermedades gastrointestinales, metabólicas, oncológicas e incluso psiquiátricas. Destacan numerosos reportes que han informado la condición de disbiosis en la obesidad, tanto en modelos animales como humanos de distintos grupos etarios y regiones del mundo. A su vez, la composición del microbioma también ha logrado asociarse a las diferentes comorbilidades de la obesidad, postulando que la MI posee influencia en la disfunción del tejido adiposo (TA), entendiendo que corresponde al principal modulador de la patogénesis de la obesidad. Sin embargo, aún no es posible establecer una explicación mecanicista plausible. Actualmente, la utilización de tecnologías multiómicas, junto con la evaluación de variables fisiológicas, nos podrían proporcionar una mejor comprensión a la incógnita planteada. Frente a esto, el presente trabajo tiene como objetivo revisar los últimos avances en la comprensión de la influencia de la microbiota intestinal en el TA y su contribución a los mecanismos relacionados con la patogénesis de la obesidad. Entre los principales mecanismos identificados, la evidencia reporta nexos fisiológicos entre la composición de la MI y la modulación de inflamación, permeabilidad intestinal y adipogénesis. Las vías implicadas derivan de la influencia de la disbiosis intestinal en el accionar de ácidos grasos de cadena corta, claudinas, macrófagos, oligosacáridos, entre otros. Los mecanismos implicados, principalmente estudiados en modelos animales, deberían ser considerados para su evaluación en próximos estudios longitudinales y experimentales en humanos con el fin de obtener una mayor comprensión sobre la implicancia de cada mecanismo en la patogenia global de la obesidad(AU)


The investigations carried out during the last century related to the description of the Gut Microbiota (GM) suggest a concrete relationship between its composition and the health of the host. Its deregulation called intestinal dysbiosis has been associated with different types of gastrointestinal, metabolic, oncological and even psychiatric diseases. Numerous reports that have described the condition of dysbiosis in obesity stand out, both in animal and human models of different age groups and regions of the world. In turn, the composition of the microbiome has also been associated with the different comorbidities of obesity, postulating that MI has an influence on adipose tissue (AT) dysfunction, understanding that it corresponds to the main modulator of the pathogenesis of obesity. However, it is not yet possible to establish a plausible mechanistic explanation. Currently, the use of multi-omics technologies, together with the evaluation of physiological variables, could provide us with a better understanding of the question raised. In view of this, this review aims to review the latest advances in understanding the influence of the intestinal microbiota on AT and its contribution to the mechanisms related to the pathogenesis of obesity. Among the main mechanisms identified, the evidence reports physiological links between the composition of GM and the modulation of inflammation, intestinal permeability and adipogenesis. The pathways involved derive from the influence of intestinal dysbiosis on the action of short-chain fatty acids, claudins, macrophages, oligosaccharides, among others. The mechanisms involved, mainly studied in animal models, should be considered for evaluation in future longitudinal and experimental studies in humans in order to obtain a better understanding of the implication of each mechanism in the global pathogenesis of obesity(AU)


Subject(s)
Adipose Tissue , Gastrointestinal Microbiome , Obesity/pathology , Energy Metabolism , Adipogenesis , Dysbiosis , Gastrointestinal Diseases
8.
Arq. ciências saúde UNIPAR ; 26(1): 33-45, Jan-Abr. 2022.
Article in Portuguese | LILACS | ID: biblio-1362669

ABSTRACT

Objetivo: Investigar a relação entre o perfil de adesão e barreiras percebidas por estudantes universitários para permanência no Programa de Extensão "Yoga: Awaken ONE". Métodos: Foram realizados dois cortes transversais com universitários da Universidade Federal do Recôncavo da Bahia. O primeiro foi composto por 16 indivíduos e investigou o perfil demográfico, socioeconômico, antropométrico, da aptidão física e da qualidade de vida dos universitários que ingressaram no Programa de Extensão. O segundo visou identificar as barreiras para permanência de 13 estudantes (dentre os 16 iniciais) que haviam se afastado do Programa após quatro meses do início. Resultados: Houve predominância de indivíduos do sexo feminino, dos cursos de graduação em Educação Física e Pedagogia e da classe socioeconômica C. A maioria dos participantes estava com indicadores adequados de gordura corporal. Observou-se grande proporção de indivíduos com indicadores baixos de flexibilidade e força muscular. Para a qualidade de vida, a menor mediana foi observada para o domínio meio ambiente e a maior para o domínio relações sociais. As principais barreiras percebidas para a prática de yoga pelos universitários foram "jornada de estudos extensa" e "jornada de trabalho extensa". Observou-se correlação do perfil sociodemográfico, indicadores de obesidade, variáveis hemodinâmicas, flexibilidade, força muscular e qualidade de vida com barreiras percebidas para permanência no Programa de Extensão universitária "Yoga: Awaken ONE". Conclusões: Estes achados sugerem que o perfil do público universitário pode ser determinante para a permanência ou evasão de programas de promoção de exercícios físicos e precisa ser considerado em propostas de programas de extensão universitária.


Objective: Investigate the relationship between the member adherence profile and barriers perceived by university students to remain in the "Yoga: Awaken ONE" Extension Program. Methods: Two cross-sections were carried out with university students from the Federal University of Recôncavo da Bahia. The first was composed of 16 individuals and investigated the demographic, socioeconomic, anthropometric, physical fitness, and quality of life profile of university students joining the Extension Program. The second aimed at identifying the barriers to remain in the program faced by 13 students (out of the initial 16) who had withdrawn from the Program four months after the beginning. Results: There was a predominance of female individuals, from undergraduate courses in Physical Education and Pedagogy, and from the C socioeconomic class. Most participants had adequate body fat indexes. There was a large proportion of individuals with low flexibility and muscle strength. For quality of life, the lowest median was observed for the environment domain, while the highest could be noted for the social relationship domain. The main barriers perceived for the practice of yoga by university students were "long study hours" and "long work hours". There was a correlation between sociodemographic profile, obesity indicators, hemodynamic variables, flexibility, muscle strength, and QOL with the perceived barriers to stay in the "Yoga: Awaken ONE" university extension program. Conclusions: These findings suggest that the profile of the university audience can be a determinant for the permanence or dropout of programs that promote physical exercise and therefore, it should be taken into consideration in proposals for university extension programs.


Subject(s)
Humans , Male , Female , Adult , Students , Universities/organization & administration , Yoga , Program Evaluation , Quality of Life/psychology , Work Hours , Exercise , Body Mass Index , Adipose Tissue , Student Health , Health Status Indicators , Range of Motion, Articular , Abdominal Fat , Adiposity , Muscle Strength , Arterial Pressure , Obesity/prevention & control
9.
Arch. latinoam. nutr ; 72(1): 23-30, mar. 2022. tab, graf
Article in Spanish | LILACS, LIVECS | ID: biblio-1368353

ABSTRACT

La obesidad se define por un exceso de masa grasa, sin embargo, hay otros indicadores antropométricos que pueden ser útiles para el diagnóstico de sobrepeso u obesidad; Objetivo. Determinar la exactitud diagnóstica del índice de masa corporal (IMC), circunferencia de la cintura (CC) e índice de forma corporal (ABSI) para el diagnóstico de sobrepeso u obesidad en una población adulta del Ecuador. Materiales y métodos. Se desarrolló un estudio observacional de corte transversal en el que participaron 253 sujetos con edades entre 20 y 60 años. Se midió peso, estatura, circunferencia de la cintura y porcentaje de grasa corporal (PGC). Se correlacionó el PGC con IMC, CC y ABSI y se estableció la sensibilidad y especificidad de estos indicadores para el diagnóstico de sobrepeso u obesidad con curvas ROC. Resultados. El PGC fue menor en hombres que en mujeres (30,9 vs 41,87), ABSI y CC fue mayor en hombres que en mujeres (0,079 vs 0,075) y (99,76 vs 91,25) respectivamente. Se encontró una correlación positiva fuerte (≥0,75) entre el PGC e IMC y CC. En la curva ROC, el área bajo la curva más alta se observa para el IMC (0,949), mientras que el área más baja se observa para ABSI (0,395). Conclusión. El IMC es el indicador con mayor precisión diagnóstica de sobrepeso u obesidad. ABSI no sería un indicador útil en el diagnóstico de sobrepeso u obesidad(AU)


Obesity is defined by an excess of fat mass, however, there are other anthropometric indicators that can be useful for the diagnosis of overweight or obesity; Objetive. To determine the diagnostic accuracy of the body mass index (BMI), waist circumference (WC) and body shape index (ABSI) for the diagnosis of overweight or obesity in an adult population of Ecuador. Materials and methods. An observational cross-sectional study was carried out in which 253 subjects aged between 20 and 60 years participated. Weight, height, waist circumference and percentage body fat (PBF) were measured. The PBF was correlated with BMI, WC and ABSI and the sensitivity and specificity of these indicators were established for the diagnosis of overweight or obesity with ROC curves. Results. The PBF was lower in men than in women (30.09 vs 41.87), ABSI and CC were higher in men than in women (0.079 vs 0.075) and (99.76 vs 91.25) respectively. A strong positive correlation (≥0.75) was found between % body fat and BMI and WC. On the ROC curve, the area under the highest curve is observed for BMI (0.949), while the lowest area is observed for ABSI (0.395). Conclusion. The BMI is the indicator with the highest diagnostic precision of overweight or obesity. ABSI would not be a useful indicator in the diagnosis of overweight or obesity(AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Body Mass Index , Adipose Tissue , Overweight , Body Fat Distribution , Obesity , Anthropometry , Cross-Sectional Studies , Diagnosis , Ecuador , Waist Circumference
10.
Arq. bras. cardiol ; 118(3): 625-633, mar. 2022. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1364342

ABSTRACT

Resumo Fundamento O tecido adiposo epicárdico (TAE) é aumentado em comorbidades comuns na insuficiência cardíaca (IC). Dessa forma, o TAE teria o potencial de mediar efeitos que levam à deterioração da função cardíaca. Objetivos Esta metanálise tem o objetivo de investigar se a quantidade de TAE em todos os tipos de IC e cada tipo de IC são significativamente diferentes dos pacientes de controle. Métodos Esta metanálise seguiu as diretrizes da Meta-analysis of Observational Studies in Epidemiology (Metanálise de estudos observacionais em epidemiologia). A pesquisa foi realizada nos bancos de dados MEDLINE, Embase e Lilacs até novembro de 2020. Dois autores realizaram a triagem, a extração de dados e a avaliação de qualidade. Um p-valor <0,05 foi definido como estatisticamente significativo. Resultados Foram incluídos oito estudos observacionais, compreendendo 1248 pacientes no total, dos quais 574 eram de controle, 415 tinham IC com fração de ejeção reduzida (ICFER) e 259 tinham IC com fração de ejeção de faixa média ou preservada (ICFEfm ou ICFEP). A quantidade de TAE não era diferente entre todos os tipos de IC e o grupo de controle (DMP = -0,66, IC 95%: -1,54 a 0,23, p =0,14) . Analisando cada fenótipo de IC separadamente, pacientes com ICFER tinham TAE reduzido em comparação aos pacientes de controle (DMP = 1,27, IC 95%: - 1,87 a -0,67, p <0,0001), enquanto os pacientes com ICFEfm ou ICFEP tiveram TAE aumentado em comparação aos pacientes de controle (DMP = 1,24, IC 95%: 0,99 a 1,50, p <0,0001). Conclusão A quantidade de TAE não era significativamente diferente entre todos os tipos de IC e o grupo de controle. Em pacientes com ICFER o volume de TAE era reduzido, enquanto em pacientes com ICFEP e ICFEfm, a quantidade de TAE era significativamente aumentada. Número de registro PROSPERO: CRD42019134441.


Abstract Background Epicardial adipose tissue (EAT) is increased in comorbidities common in heart failure (HF). In this sense, EAT could potentially mediate effects that lead to an impaired cardiac function. Objectives This meta-analysis aims to investigate if the amount of EAT in all-types of HF and each HF phenotype is significantly different from control patients. Methods This meta-analysis followed the Meta-analysis Of Observational Studies in Epidemiology guidelines. The search was performed in the MEDLINE, Embase, and Lilacs databases until November 2020. Two authors performed screening, data extraction, and quality assessment. A p-value <0.05 was defined as statistically significant. Results Eight observational studies were included, comprehending 1,248 patients in total, from which 574 were controls, 415 had HF with reduced ejection fraction (HFrEF) and 259 had HF with mid-range or preserved ejection fraction (HFmrEF or HFpEF). The amount of EAT was not different between all types of HF and the control group (SMD = -0.66, 95% CI: -1.54 to 0.23, p =0.14). Analyzing each HF phenotype separately, patients with HFrEF had a reduced EAT when compared to the controls (SMD= -1.27, 95% CI: - 1.87 to -0.67, p <0.0001), while patients with HFmrEF or HFpEF showed an increased EAT when compared to controls (SMD= 1.24, 95% CI: 0.99 to 1.50, p <0.0001). Conclusion The amount of EAT was not significantly different between all types of HF and the control group. In patients with HFrEF, the EAT volume was reduced, whereas in HFpEF and HFmrEF, the amount of EAT was significantly increased. PROSPERO registration number: CRD42019134441.


Subject(s)
Humans , Heart Failure , Phenotype , Prognosis , Stroke Volume , Adipose Tissue , Observational Studies as Topic
11.
Rev. bras. ciênc. mov ; 29(2): [1-14], mar. 2022. Ilus, Tab
Article in Portuguese | LILACS | ID: biblio-1363708

ABSTRACT

A prescrição de exercícios físicos em intensidades moderada e alta, para indivíduos obesos, pode induzir maiores percepções de desconforto/desprazer e, consequentemente, desencorajá-los a aderir a uma rotina de exercícios físicos. O objetivo deste trabalho foi investigar os efeitos de um programa de treinamento de força com intensidade autosselecionada, na composição corporal, hipertrofia e qualidade do sono de uma voluntária recémsubmetida a cirurgia bariátrica (idade: 28 anos; altura: 158cm; peso: 69 kg; índice de massa corporal: 27,64). A voluntária realizou um programa de treinamento de força com intensidade autosselecionada, pelo período de oito semanas (2 sessões semanais). Foi avaliada a qualidade de sono, por meio do questionário Pittsburgh sleep quality index; a composição corporal, por absorciometria de feixe duplo; e, a espessura muscular e do tecido adiposo, por ultrassonografia; antes e após a intervenção. Antes e após as sessões de treinamento, a percepção de prazer/desprazer foi mensurada com o auxílio de uma escala de valência afetiva. O programa de exercícios com intensidade autosselecionada resultou em uma diminuição de 2% no percentual de gordura, e de 7% na massa corporal total; sem modificação para a massa livre de gordura. Houve redução de 22% na espessura do tecido adiposo, e de 11% na espessura muscular do bíceps braquial; de 28% na espessura do tecido adiposo, e de 4% na espessura muscular do vasto lateral. A voluntária reportou percepção de prazer/desprazer positiva na maioria das sessões. No entanto, não houve diferença significativa entre os resultados para qualidade de sono. O treinamento com intensidade autosselecionada promoveu respostas positivas, relacionadas à percepção de prazer/desprazer, além de favorecer uma tendência à perda significativa de massa corporal total, sem prejuízos para a massa magra.(AU)


The prescription of physical exercise in moderate and high intensities for obese individuals may induce greater perceptions of discomfort/displeasure, consequently, decline adherence to a physical exercise routine. The objective of this study was investigate the effects of a strength training program with self-selected intensity, body composition, hypertrophy and sleep quality of a participant recently bariatric surgery (age: 28 years; height: 158cm; weight: 69 kg; body mass index: 27.64). The participant performed a strength training program with self-selection intensity, for a period of eight weeks (2 weekly sessions). Sleep quality was evaluated using the Pittsburgh sleep quality index questionnaire; body composition, by dual-energy x-ray absorptiometry, muscle and adipose tissue thickness by ultrasound. Each measure was before and after the intervention. Before and after the training sessions, the perception of pleasure/displeasure was measured with the affective valence scale. The exercise program with self-selected intensity resulted in a 2% decrease in fat percentage, and 7% in total body mass; without modification to the fat-free mass. Yet, there was a reduction of 22% in the thickness of adipose tissue, and 11% in the muscle thickness of the brachial biceps; 28% in the thickness of adipose tissue, and 4% in the muscle thickness of the vastus lateralis. The participant reported a perception of positive pleasure in most sessions. However, there was no significant difference between the results for sleep quality. The training with self-selected intensity promoted positive responses, related to the perception of pleasure/displeasure, besides promote a tendency to significant loss of total body mass, without damage to lean mass. (AU)


Subject(s)
Humans , Female , Adult , Body Composition , Absorptiometry, Photon , Body Mass Index , Adipose Tissue , Bariatric Surgery , Resistance Training , Fats , Hypertrophy , Perception , Sleep , Weights and Measures , Exercise , Surveys and Questionnaires , Pleasure , Muscles
12.
Rev. Assoc. Med. Bras. (1992) ; 68(2): 250-255, Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1365337

ABSTRACT

SUMMARY OBJECTIVE: The metabolic syndrome involves both metabolic and cardiovascular risk factors and is associated with cardiovascular mortality. Epicardial fat tissue plays a crucial role in deleterious effects of metabolic syndrome on the heart, including myocardial fibrosis. The fragmented QRS reflects heterogeneous depolarization of the myocardium and occurs as a result of fibrosis. Thus, we aimed to investigate whether there is an association between fragmented QRS and epicardial fat tissue in patients with metabolic syndrome. METHODS: This study enrolled 140 metabolic syndrome patients, of whom 35 patients with fragmented QRS (+) and 105 patients with fragmented QRS (−). The two groups were compared with respect to clinical, laboratory, electrocardiographic, and echocardiographic indexes. RESULTS: Fragmented QRS (+) patients had higher waist circumference, red cell distribution width, creatinine, left ventricular end-systolic diameter, left atrium diameter, septal a velocity, QRS duration, and epicardial fat tissue compared with fragmented QRS (−) patients. Waist circumference, red cell distribution width, QRS duration, left ventricular end-systolic diameter, left atrium diameter, septal a velocity, and epicardial fat tissue were significantly associated with the presence of fragmented QRS. The QRS duration and epicardial fat tissue were independently associated with the presence of fragmented QRS on surface electrocardiographic in metabolic syndrome patients. CONCLUSIONS: Epicardial fat tissue and QRS duration were independently associated with the presence of fragmented QRS. Basic echocardiographic and electrocardiographic parameters might be used for the risk stratification in metabolic syndrome patients.


Subject(s)
Humans , Metabolic Syndrome/complications , Echocardiography , Adipose Tissue/diagnostic imaging , Electrocardiography/methods , Waist Circumference
13.
Braz. dent. sci ; 25(2): 1-6, 2022. ilus, tab
Article in English | LILACS, BBO | ID: biblio-1363723

ABSTRACT

Objective: The aim this research was assess the level of satisfaction of patients undergoing bichectomy and its repercussions. Material and Methods: A cross-sectional and qualitative study, under protocol number 20707519.5.0000.5207, was carried out by applying a questionnaire to patients undergoing bichectomy, which made it possible to assess complaints, degree of postoperative satisfaction, satisfaction of family members, time required to perceive results, complications and adverse effects, intensity of postoperative pain, and possibility of being submitted to a new intervention. Results: The sample consisted of 30 patients, among them, 82% sought surgery for aesthetic reasons. Regarding the degree of satisfaction, the majority (70%) were very satisfied, followed by 13.3% who were satisfied, 10% considered normal, 3.3% were dissatisfied and 3.3% very dissatisfied. Regarding the opinion of friends and family, the majority were very satisfied with the result. The adverse effects found were mild, no permanent injury happened, and the pain was mild in the most majority of the sample. Conclusion: Thus, the most majority of patients were satisfied with the results, as well as their family and friends. The results were more evident between the second and third months. No major or permanent damage was observed, suggesting that it is a safe technique when performed well.(AU)


Objetivo: Avaliar o nível de satisfação dos pacientes submetidos à bichectomia, bem como correlacionar os resultados com algumas características clínicas. Material e Métodos: Foi realizado um estudo transversal e qualitativo, sob protocolo número 20707519.5.0000.5207, através da aplicação de um questionário a pacientes submetidos à bichectomia, o qual foi possível avaliar as queixas, o grau de satisfação pós-operatório, a satisfação dos familiares, o tempo para percepção dos resultados, as complicações e efeitos adversos, intensidade da dor pós operatória, e a possibilidade de ser submetido a nova intervenção. Além disso, as características demográficas da amostra (como sexo e idade) também foi registrada na ficha de avaliação. Resultados: A amostra foi composta por 30 pacientes, e desses, 82% buscaram a cirurgia por motivos estéticos. Sobre o grau de satisfação, a maioria (70%) ficou muito satisfeitos, seguidos por 13,3% que ficaram satisfeitos, 10% consideraram normal, 3,3% insatisfeitos e 3,3% muito insatisfeitos. Sobre a opinião dos amigos e familiares, a maioria ficou muito satisfeitos com o resultado. Os efeitos adversos encontrados foram leves, nenhuma lesão permanente foi encontrada, e a dor foi discreta na grande maioria da amostra. Com base na possibilidade de submeter-se a uma nova cirurgia, 70% ficaram satisfeitos e não fariam novamente. Conclusão: A grande maioria dos pacientes demonstrou-se satisfeitos com os resultados, bem como seus familiares e amigos. Os resultados foram mais evidentes entre o segundo e terceiro mês. Não foi observado qualquer dano importante ou permanente, sugerindo ser uma técnica segura quando bem executada. (AU)


Subject(s)
Humans , Adipose Tissue , Patient Satisfaction , Esthetics, Dental , Mastication
14.
Article in Chinese | WPRIM | ID: wpr-936192

ABSTRACT

Objective: To investigate the effects of adipose-derived mesenchymal stem cells (ADMSCs) on proliferation and hormone secretion of parathyroid cells in votro. Methods: The parathyroid cells and ADMSCs were obtained from 10 SD rats by cell separation and culture. The phenotype of P3 generation for ADMSCs was detected by flow cytometry. The co-culture of parathyroid cells and ADMSCs was conducted in the ratios of 2∶1, 1∶1, 1∶2 and 1∶5, respectively. The level of parathyroid hormone in cell supernatant was determined. The results were compared with the parathyroid hormone in the supernatant of parathyroid cells cultured separately in the corresponding number. The effects of ADMSCs on the hormone secretion of parathyroid cells were evaluated. SPSS 11.0 software was used for statistical analysis. Results: The primary culture of either parathyroid cells or ADMSCs and the co-culture of these cells in vitro were performed successfully, and the in vitro culture of different proportions of the two cells showed different effects on parathyroid hormone secretion. The co-culture of parathyroid cells and ADMSCs, especially in the ratio of 1∶5, facilitated the secretion of parathyroid hormone ((1.3±0.0) vs. (0.8±0.1), (1.3±0.0) vs. (0.9±0.0), (1.7±0.5) vs. (0.9±0.0), (1.7±0.0) vs. (1.2±0.2))ng/L with t value of 25.46, 64.30, 3.32, 7.16, P<0.05 on the 2nd, 4th, 6th and 8th days respectively. Secondly, when the ratio was 1∶2, the PTH level showed an upward trend. Conclusion: Parathyroid cells and ADMSCs can be co-cultured in vitro, facilitating the secretion of parathyroid hormone under the appropriate cell proportion such as the ratio of by parathyroid cells to ADMSCs at 1∶5.


Subject(s)
Adipose Tissue , Animals , Coculture Techniques , Mesenchymal Stem Cells , Rats , Rats, Sprague-Dawley
15.
Article in English | WPRIM | ID: wpr-939849

ABSTRACT

Human adipose-derived stem cells (hASCs) are a promising cell type for bone tissue regeneration. Circular RNAs (circRNAs) have been shown to play a critical role in regulating various cell differentiation and involve in mesenchymal stem cell osteogenesis. However, how circRNAs regulate hASCs in osteogenesis is still unclear. Herein, we found circ_0003204 was significantly downregulated during osteogenic differentiation of hASCs. Knockdown of circ_0003204 by siRNA or overexpression by lentivirus confirmed circ_0003204 could negatively regulate the osteogenic differentiation of hASCs. We performed dual-luciferase reporting assay and rescue experiments to verify circ_0003204 regulated osteogenic differentiation via sponging miR-370-3p. We predicted and confirmed that miR-370-3p had targets in the 3'-UTR of HDAC4 mRNA. The following rescue experiments indicated that circ_0003204 regulated the osteogenic differentiation of hASCs via miR-370-3p/HDAC4 axis. Subsequent in vivo experiments showed the silencing of circ_0003204 increased the bone formation and promoted the expression of osteogenic-related proteins in a mouse bone defect model, while overexpression of circ_0003204 inhibited bone defect repair. Our findings indicated that circ_0003204 might be a promising target to promote the efficacy of hASCs in repairing bone defects.


Subject(s)
Adipose Tissue/metabolism , Animals , Cell Differentiation/genetics , Cells, Cultured , Histone Deacetylases/metabolism , Humans , Mice , MicroRNAs/metabolism , Osteogenesis/genetics , RNA, Circular/metabolism , Repressor Proteins/metabolism , Signal Transduction , Stem Cells/metabolism
16.
Article in Chinese | WPRIM | ID: wpr-928094

ABSTRACT

This study investigated the effects and mechanisms of 6-gingerol on adipose tissue insulin resistance in naturally aging rats with glycolipid metabolism disorders. Twenty-seven aging male SD rats were randomly divided into a model group(aged, n=9) and two groups treated with 6-gingerol at 0.05 mg·kg~(-1)(G-L, n=9) and 0.2 mg·kg~(-1)(G-H, n=9). Six young rats were randomly assigned to a normal control group(NC). Rats were treated for seven weeks by gavage. Non-esterified fatty acid(NEFA) and insulin content was determined by enzyme-linked immunosorbent assay(ELISA), and adipose tissue insulin resistance index(Adipo-IR) was calculated. HE staining was used to observe the size of adipocytes in epididymal white adipose tissue(eWAT). The gene and protein expression levels of adiponectin receptor 1(AdipoR1), AMP-activated protein kinase α(AMPKα), phosphorylated AMPK(p-AMPKα~(Thr172)), peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α), phosphatidylinositol 3-kinase(PI3 K), protein kinase B(Akt), phosphorylated Akt(p-Akt~(Ser473)), tumor necrosis factor-α(TNF-α), c-Jun N-terminal kinase 1/2(JNK1/2), phosphorylated JNK1/2(p-JNK~(Thr183/Tyr185)), interleukin-1β(IL-1β), and interleukin-6(IL-6) in adiponectin(APN), insulin, and inflammatory factor signaling pathways were detected by Western blot and real-time RCR, respectively. The results showed that 6-gingerol at a high dose could significantly decrease the fasting plasma content of NEFA and insulin and reduce Adipo-IR. Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1α, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-α, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2. This study reveals that 6-gingerol can improve insulin sensitivity of adipose tissues in aging rats with glycolipid metabolism disorders, and this effect is presumedly achieved by enhancing the PI3 K/Akt signaling pathway, inhibiting adipose tissue inflammation, increasing APN synthesis, enhancing AdipoR1 expression, and activating its downstream AMPK/PGC-1α signaling pathway.


Subject(s)
Adipose Tissue , Aging , Animals , Catechols , Fatty Alcohols , Insulin Resistance , Male , Rats , Rats, Sprague-Dawley
17.
Article in English | WPRIM | ID: wpr-927628

ABSTRACT

OBJECTIVE@#This study aims to investigate the association of metabolic phenotypes that are jointly determined by body mass index (BMI) or fat mass percentage and metabolic health status with the ten-year risk of cardiovascular disease (CVD) among Chinese adults.@*METHODS@#Data were obtained from a cross-sectional study. BMI and body fat mass percentage (FMP) combined with the metabolic status were used to define metabolic phenotypes. Multiple linear regression and logistic regression were used to examine the effects of metabolic phenotypes on CVD risk.@*RESULTS@#A total of 13,239 adults aged 34-75 years were included in this study. Compared with the metabolically healthy non-obese (MHNO) phenotype, the metabolically unhealthy non-obese (MUNO) and metabolically unhealthy obese (MUO) phenotypes defined by BMI showed a higher CVD risk [odds ratio, OR (95% confidence interval, CI): 2.34 (1.89-2.89), 3.45 (2.50-4.75), respectively], after adjusting for the covariates. The MUNO and MUO phenotypes defined by FMP showed a higher CVD risk [ OR (95% CI): 2.31 (1.85-2.88), 2.63 (1.98-3.48), respectively] than the MHNO phenotype. The metabolically healthy obese phenotype, regardless of being defined by BMI or FMP, showed no CVD risk compared with the MHNO phenotype.@*CONCLUSION@#General obesity without central obesity does not increase CVD risk in metabolically healthy individuals. FMP might be a more meaningful factor for the evaluation of the association of obesity with CVD risk. Obesity and metabolic status have a synergistic effect on CVD risk.


Subject(s)
Adipose Tissue/anatomy & histology , Adult , Aged , Body Mass Index , Cardiovascular Diseases/etiology , China/epidemiology , Cross-Sectional Studies , Female , Humans , Male , Metabolic Diseases/etiology , Middle Aged , Obesity/complications , Phenotype , Regression Analysis , Risk Factors
18.
Int. j. morphol ; 40(4): 927-932, 2022. tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1405236

ABSTRACT

RESUMEN: La Bioimpedancia Eléctrica (BIA), al ser una técnica no invasiva pero de elevada precisión, se ha convertido en la actualidad en una herramienta valiosa para determinar la composición corporal en militares, facilitado el control de las distintas variables que se asocian a cada especialidad. El objetivo del presente estudio fue describir el perfil de composición corporal en militares de elite al momento de finalizar un curso de especialización. Participaron 11 militares con un rango de edad entre 22 y 29 años. Se evalúo la composición corporal a través de BIA, inmediatamente después de finalizado un curso de especialización para militares de élite. Las evaluaciones en los militares sobre las variables de la composición corporal a través de BIA mostraron: peso corporal de 84,3 ± 4,52 kg, talla 1,78 ± 0,06 m, índice de masa corporal (IMC) 26,5 ± 1,09, tejido adiposo de 13,7 ± 3,65 %, tejido muscular 49,5 ± 2,34 %, masa libre de grasa 72,7 ± 5,23 kg y 53,2 ± 3,78 l de agua corporal total. Conclusiones: Los militares de elite presentaron elevados niveles de masa libre de grasa, tejido muscular y bajos niveles de tejido adiposo lo que favorece el desarrollo de las actividades militares especializadas y disminuye el riesgo de lesiones. Los datos aquí recogidos sirven como marco de referencia para futuros estudios.


SUMMARY: Electrical bioimpedance (BIA), being a non- invasive technique but with high precision, has become a valuable tool for determining body composition in the military, facilitating the control of the different variables associated with each specialty. The aim of the present study was to describe the body composition profile of elite military personnel at the end of a specialization course. Eleven military personnel between 22 and 29 years of age participated in the study. Body composition was assessed by BIA immediately after completion of a specialization course for elite military personnel. Assessments in the military on body composition variables through BIA showed: body weight of 84.3 ± 4.52 kg, height 1.78 ± 0.06 m, body mass index (BMI) 26.5 ± 1.09, adipose tissue of 13.7 ± 3.65 %, muscle tissue 49.5 ± 2.34 %, fat free mass 72.7 ± 5.23 kg and 53.2 ± 3.78 l of total body water. Conclusions: Elite military personnel presented high levels of fat free mass, muscle tissue and low levels of adipose tissue which favors the development of specialized military activities and decreases the risk of injury. The data collected here serve as a frame of reference for future studies.


Subject(s)
Humans , Male , Adult , Young Adult , Body Composition , Military Personnel , Body Mass Index , Chile , Adipose Tissue , Electric Impedance , Organism Hydration Status
19.
Arq. bras. cardiol ; 117(4): 737-747, Oct. 2021. tab, graf
Article in Portuguese | LILACS | ID: biblio-1345234

ABSTRACT

Resumo Fundamento A síndrome metabólica é caracterizada por um conjunto de comorbidades. Durante a síndrome, observam-se alterações estruturais no sistema cardiovascular, especialmente o remodelamento vascular. Uma das causas predisponentes para essas alterações é a inflamação crônica oriunda de mudanças na estrutura e composição do tecido adiposo perivascular. Atorvastatina é eficaz no tratamento das dislipidemias. No entanto, seus efeitos pleiotrópicos não são totalmente compreendidos. Supõe-se que, durante a síndrome metabólica, ocorre remodelamento vascular e que o tratamento com atorvastatina pode ser capaz de atenuar tal condição. Objetivos Avaliar os efeitos do tratamento com atorvastatina sobre o remodelamento vascular em modelo experimental de síndrome metabólica. Métodos Camundongos Swiss receberam dieta controle ou dieta hiperglicídica por 18 semanas. Após 14 semanas de dieta, os camundongos foram tratados com veículo ou atorvastatina (20mg/kg) durante 4 semanas. Foram avaliados o perfil nutricional e metabólico por testes bioquímicos; análise estrutural da artéria aorta por histologia e dosagem de citocinas por ensaio imunoenzimático. O nível de significância aceitável para os resultados foi p <0,05. Resultados A dieta hiperglicídica promoveu o desenvolvimento de síndrome metabólica. Tal fato culminou no remodelamento hipertrófico do músculo liso vascular e tecido adiposo perivascular. Além disso, houve aumentos das citocinas TNF-α e IL-6 circulantes e no tecido adiposo perivascular. O tratamento com atorvastatina reduziu significativamente os danos metabólicos, o remodelamento vascular e os níveis de citocinas. Conclusão Atorvastatina ameniza danos metabólicos associados à síndrome metabólica induzida por dieta hiperglicídica, além de atenuar o remodelamento vascular, sendo esses efeitos associados à redução de citocinas pró-inflamatórias.


Abstract Background Metabolic syndrome is characterized by an array of comorbidities. During this syndrome, structural changes are observed in the cardiovascular system, especially vascular remodeling. One of the predisposing causes for these changes is chronic inflammation resulting from changes in the structure and composition of perivascular adipose tissue. Atorvastatin is effective in the treatment of dyslipidemias. However, its pleiotropic effects have not been completely understood. We hypothesize that metabolic syndrome may lead to vascular remodeling and that atorvastatin therapy may be able to attenuate this condition. Objectives To assess the effects of atorvastatin therapy on vascular remodeling in an experimental model of metabolic syndrome. Methods Swiss mice received a control diet or a hyperglicemic diet for 18 weeks. After 14 weeks of diet, mice were treated with vehicle or atorvastatin (20mg/kg) during for 4 weeks. Nutritional and metabolic profiles were assessed by biochemical tests; moreover, a histological assessment of aorta structure was conducted, and cytokine levels were determined by the immunoenzyme assay. The acceptable level of significance for the results was set at p<0.05. Results Hyperglicemic diet promoted the development of metabolic syndrome. It indeed culminated in hypertrophic remodeling of vascular smooth muscle and perivascular adipose tissue. Furthermore, there were increases in the levels of circulating TNF-α and IL-6 and in the perivascular adipose tissue. Atorvastatin therapy significantly reduced metabolic damages, vascular remodeling, and cytokine levels. Conclusion Atorvastatin attenuate metabolic damages associated with metabolic syndrome induced by hyperglycemic diet, in addition to attenuating vascular remodeling; both effects are associated with reduced levels of pro-inflammatory cytokines.


Subject(s)
Animals , Mice , Metabolic Syndrome/drug therapy , Adipose Tissue , Cytokines , Vascular Remodeling , Atorvastatin/pharmacology
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