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Introducción. La fuga anastomótica es una complicación que en las últimas tres décadas ha mantenido sus tasas de incidencia entre 1 % y 19 % y ha alcanzado una mortalidad que varía entre 6 % y 22 %. Tiene una alta morbilidad, siendo responsable del 56 % de los estomas definitivos en pacientes sometidos a cirugía colorrectal. El objetivo de este estudio fue identificar los factores asociados con un mayor riesgo de incidencia de fuga anastomótica, para lograr impactar en la morbilidad y mortalidad de los pacientes llevados a cirugía colorrectal. Métodos. Estudio de casos y controles multicéntrico enfocado en los factores de riesgo preoperatorios e intraoperatorios asociados con la fuga anastomótica después de la resección de colon. Resultados. Se incluyeron 480 pacientes llevados a cirugía colorrectal entre enero de 2014 y diciembre de 2019. Se estimó que existe mayor riesgo de presentar dehiscencia de anastomosis con nivel de hemoglobina menor de 9 g/dl (p=0,001; OR=3,2; IC95%: 1,64-6,25), clasificación ASA > 3 (p=0,001; OR=9,96; IC95%: 4,75-20,9), duración prolongada de la cirugía (p=0,005) y necesidad de transfusión intraoperatoria (p=0,001; OR=4,57; IC95%: 2,32-9,01). El reforzamiento de la anastomosis se relacionó a un menor número de fugas anastomóticas (p=0,001; OR=0,14; IC95%: 0,04-0,46). Conclusión. La anemia y la transfusión de glóbulos rojos se relacionaron con un aumento de fuga anastomótica. Por otro lado, el refuerzo de la anastomosis se presenta como una medida potencialmente beneficiosa para mitigar la incidencia de esta complicación. La identificación precisa de estos factores de riesgo ofrece la oportunidad de transformar la fuga anastomótica en una complicación prevenible.

Introduction. Anastomotic leak is a complication that in the last three decades has maintained its incidence rates between 1% and 19% and has reached a mortality rate that varies between 6% and 22%. It has a high morbidity rate, being responsible for 56% of definitive stomas in patients undergoing colorectal surgery. The objective of this study was to identify factors associated with a higher risk of anastomotic leak incidence, in order to impact the morbidity and mortality of patients undergoing colorectal surgery. Methods. Multicentric case-control study focused on preoperative and intraoperative risk factors associated with anastomotic leak after colon resection. Results. 480 patients who underwent colorectal surgery between January 2014 and December 2019 were included. It was estimated that there is a higher risk of anastomotic dehiscence with hemoglobin levels <9 mg/dl (p=0.001; OR=3.2; 95% CI: 1.64-6.25), ASA classification >3 (p=0.001; OR=9.96; 95% CI: 4.75-20.9), prolonged surgery duration (p=0.005), and the need for intraoperative transfusion (p=0.001; OR=4.57; 95% CI: 2.32-9.01). Anastomosis reinforcement was related to fewer anastomotic leaks (p=0.001; OR=0.14; 95% CI: 0.04-0.46). Conclusion. Anemia and red blood cell transfusion were associated with an increased anastomotic leak. On the other hand, anastomosis reinforcement is presented as a potentially beneficial measure to mitigate the incidence of this complication. Accurate identification of these risk factors offers the opportunity to transform anastomotic leak into a preventable complication.

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El manual del registro y codificación de la prevención y control de la anemia por deficiencia de hierro en el niño y niña, adolescente, mujeres en edad fértil, gestantes y puérperas, está elaborado bajo la Norma Técnica Nro. 213-MINSA/DGIESP-2024 "Norma Técnica de Salud: Prevención y control de la anemia por deficiencia de hierro en el niño y la niña, adolescentes, mujeres en edad fértil, gestantes y puérperas" aprobado el 08 de abril del 2024 y su modificatoria con Resolución Ministerial N° 429-2024/MINSA aprobada el 18 de junio del 2024; lo cual se elaboró la estructura del presente manual para poder aplicar en los diversos grupos etarios que están relacionados con la prevención y tratamiento de la anemia. Una de las características previo a la administración de hierro es la medición de hemoglobina, en función de los resultados obtenidos se determinará iniciar una suplementación preventiva o tratamiento de anemia. Por otra parte, es necesario monitorear la cantidad de producto de hierro que se brinda a los pacientes, para evitar el uso innecesario de frascos de hierro. Así mismo, el correcto registro de las prestaciones en HIS MINSA asegura la calidad de la información y así poder hacer seguimiento de los diversos indicadores que se generan desde el MINSA, así como mejorar las coberturas sanitarias

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Introducción: La anemia es una enfermedad de prevalencia mundial caracterizada por ineficacia de los eritrocitos para distribuir oxígeno, cuya principal etiología es ferropénica. Existen métodos mundialmente conocidos para combatirla; sin embargo, Latinoamérica dispone de escasa evidencia sobre el impacto de estas en la reducción de prevalencia de anemia. Objetivo: El presente estudio revisó las intervenciones del sector salud y multisectoriales para la reducción de anemia en niños de 6 meses a 5 años en Latinoamérica. Materiales y métodos: Se realizó una revisión exhaustiva de la literatura con las palabras clave: child, anemia, Latin America, prevention and control en las bases de datos de Embase, Pubmed, La Biblioteca Virtual en Salud (BVS) y Google Scholar, los artículos fueron filtrados en 4 etapas (identificación, selección, elegibilidad e inclusión) individualmente por los autores quedando 9 ensayos clínicos aleatorizados elegibles. Resultados: De los ensayos se encontraron intervenciones como micronutrientes en polvo (MNP), suplemento alimenticio Nutrisano, bebida láctea Nutrisano, jarabes, ollas de hierro y galletas fortificadas con plantas. Se halló que los MNP, jarabes y galletas con caupí reducen la anemia significativamente; sin embargo, por factores como adherencia y eficiencia los MNP y las galletas son las más recomendadas. El uso de la bebida láctea Nutrisano + MNP y el uso de ollas de hierro no redujeron la anemia significativamente. Conclusiones: En Latinoamérica se recomiendan los MNP según Neufeld para reducir la anemia, y las galletas fortificadas con caupí según Landim para incrementar la hemoglobina(AU)

Introduction: Anemia is a worldwide prevalence disease characterized by inefficiency of erythrocytes to distribute oxygen, whose main etiology is iron deficiency. There are worldwide known methods to combat it; however, Latin America has little evidence on the impact of these methods in reducing the prevalence of anemia. Objective: The present study reviewed health sector and multisectoral interventions for the reduction of anemia in children aged 6 months to 5 years in Latin America. Materials and methods: An exhaustive review of the literature was carried out with the keywords: child, anemia, Latin America, prevention and control in the Embase, Pubmed, La Biblioteca Virtual en Salud (BVS) and Google scholar databases, the articles were filtered in 4 stages (identification, selection, eligibility and inclusion) individually by the authors, leaving 9 eligible randomized clinical trials. Results: From the trials, interventions such as micronutrient powder (MNP), Nutrisano food supplement, Nutrisano milk drink, syrups, iron pots and plant-fortified cookies were found. MNP, syrups and cookies with cowpea were found to reduce anemia significantly; however, for factors such as adherence and efficiency MNP and cookies are the most recommended. The use of Nutrisano milk drink + MNP and the use of iron pots did not significantly reduce anemia. Conclusions: In Latin America, MNP according to Neufeld are recommended to reduce anemia, and cookies fortified with cowpea according to Landim to increase hemoglobin(AU)

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Introducción: La anemia es frecuentemente subdiagnosticada dada su vaga sintomatología. Estudios con evaluación subjetiva-visual por expertos describen signos tomográficos sugerentes de anemia, tales como el septo denso. Proponemos que lectores con entrenamiento básico realicen mediciones objetivas de alto poder estadístico para la detección de anemia. Material y Métodos: Se cruzaron datos de tomografía computarizada (TC) de tórax no contrastada (2021) con medición de hemoglobina plasmática (Hb) realizada 24 horas antes o después del estudio tomográfico. Dos estudiantes de Medicina, previamente entrenados, realizaron mediciones de Unidades Hounsfield (UH) en el septo interventri-cular (SIV) y cavidades ventriculares derecho (VD) e izquierdo (VI). Las relaciones SIV/VI y SIV/VD se correlacionaron con los valores de Hb. Se analizó la variabilidad interob-servador y se determinó el punto de corte óptimo para detectar anemia. Resultados: En una muestra de 112 casos, hubo alta concordancia interobservador con r de 0,85 (VD), 0,67 (SIV) y 0,87 (VI). La relación SIV/VI obtuvo el mayor AUC con 0,86 (IC 95%: 0,72 a 0,91), con una sensibilidad de 80% y especificidad de 88% utilizando un punto de corte de 1,15. Conclusiones: La razón SIV/VI con punto de corte de 1,15 es un parámetro confiable para detectar anemia mediante TC de tórax no contrastada, en observadores con entrenamiento básico.

Introduction: Anemia is frequently underdiagnosed given its vague symptomatology. Studies with subjective-visual evaluation by experts describe tomographic signs suggestive of anemia, such as a dense septum. This study aims to evaluate if readers with basic training can perform high statistical value measurements for anemia detection. Material and Methods: Data of non-contrast thoracic computed tomography (CT) (2021) with a measurement of plasma hemoglobin (Hb) performed 24 hours before or after the CT were identified. Two previously trained medical students performed measurements of Hounsfield Units (HU) on the interventricular septum (IVS) and right (RV) and left (LV) ventricular cavities. The SIV/VI and SIV/VD ratios were correlated with Hb values. Interobserver variability was analyzed and the optimal cut-off point to detect anemia was determined. Results: In a sample of 112 cases, there was a high interobserver correlation with r of 0.85 (VD), 0.67 (SIV), and 0.87 (VI). SIV/VI ratio obtained the highest AUC with 0.86 (95% CI: 0.72 to 0.91), with a sensitivity of 80% and specificity of 88% using a cut-off point of 1.15. Conclusions: The SIV/VI ratio with a cut-off point of 1.15 is a reliable parameter to detect anemia using non-contrast chest CT in observers with basic training.

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Objetivos: La ganglioneuromatosis intestinal (GNMI) es una enfermad neoplásica benigna poco frecuente. Se describe en general en los niños, en asociación con neoplasia endocrina múltiple (NEM) tipo 2b (asociado a cáncer medular de tiroides y neurofibromatosis tipo 1). La Ganglioneuromatosis es rara en adultos, siendo particularmente en forma esporádica y aislada. Caso Clínico: Presentamos un paciente con ganglioneuromatosis intestinal, en que los hallazgos clínicos y radiográficos simulaban una enfermedad de Crohn. Se realizó una resección de intestino delgado, debido a una oclusión de la Capsula Endoscópica, que permitió estudiar el segmento resecado, cuyo estudio de la Inmunohistoquímica sugirió un ganglio neuroma del intestino delgado. Conclusiones: La presentación clínica de esta patología es variable. El paciente puede ser oligo-sintomático, o tener una presentación atípica. Este diagnóstico debe considerarse cuando se han excluido las causas más frecuentes de anemia por deficiencia de hierro. El diagnóstico definitivo es posible después de la resección y el análisis patológico del segmento involucrado

Objective: Intestinal ganglioneuromatosis (IGNM) is a rare benign neoplastic disease. It is generally described in children in association with multiple endocrine neoplasms (MEN) type 2b (associated with medullary thyroid cancer and neurofibromatosis type 1). The intestinal ganglioneuromatosis is a rare condition in adults, particularly in sporadic and isolated form. Case Report: We introduced a patient with intestinal ganglioneuromatosis (GNMI) in which clinical and radiographic findings mimicked those of Crohn's disease. A small bowel intestinal resection was performed due to occlusion of the Endoscopic Capsule, which allowed the dry segment to be studied, whose immunohistochemistry study suggested small bowel ganglioneuroma. Conclusion: The clinical presentation of this pathology is variable. The patient may be asymptomatic or have an atypical presentation. This diagnosis should be considered when the most common causes of iron deficiency anemia have been excluded. Definitive diagnosis is possible after resection and pathologic analysis of the segment involved.

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Objetivo: Comparar el diagnóstico y manejo de la anemia durante el embarazo en mujeres de zonas urbanas y rurales. Métodos: Estudio descriptivo transversal, basado en un análisis de una encuesta nacional de salud del 2022. Se incluyeron registros de 18 889 mujeres con un embarazo en los últimos 5 años. Se estimaron frecuencias y porcentajes ponderados; además se aplicó la prueba chi cuadrado a un nivel de significancia del 0,05. Resultados: Al 94 % de mujeres se les realizó el descarte de anemia, este procedimiento fue más frecuente en zonas urbanas (94,9 %), comparado a las rurales (91,1 %). La mayor parte de las mujeres no recibió el diagnóstico de anemia, pero no hubo diferencias entre las zonas rurales (29,8 %) y urbanas (28,3 %). Respecto a la indicación y cumplimiento del tratamiento para la anemia, esto fue significativamente mayor en las parejas urbanas, con un porcentaje de 96,7 % y 65,5 %, respectivamente. Conclusión: En las zonas urbanas, fue mayor el porcentaje de mujeres en quienes se realizó descarte de anemia, así como la indicación del tratamiento y su cumplimiento. El diagnóstico de anemia no mostró diferencias entre ambas zonas(AU)

Objective: To compare the diagnosis and management of anemia during pregnancy in urban and rural women. Methods: Cross-sectional descriptive study, based on an analysis of a national health survey from 2022. Records of 18889 women with a pregnancy in the last 5 years were included. Frequencies and weighted percentages were estimated; in addition, the chi-square test was applied at a significance level of 0.05. Results: 94% of women were screened for anemia; this procedure was more frequent in urban areas (94.9%) compared to rural areas (91.1%). Most women were not diagnosed with anemia, but there was no difference between rural (29.8%) and urban (28.3%) areas. Regarding indication and adherence to treatment for anemia, this was significantly higher in urban couples, at 96.7% and 65.5%, respectively. Conclusion: In urban areas, the percentage of women of anemia ruling out, as well as treatment indication and compliance was higher. The diagnosis of anemia showed no differences between the two areas(AU)

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Anemia is frequent in preterm infants. Red blood cell transfusion practices vary between different centers. The objective of this study was to review red blood cell transfusion practices in preterm infants between 2020 and 2021. This was a narrative review that included studies published on PubMed (Medline) and Web of Science between October 2020 and October 2021. Ten studies were included finally. Red blood cell transfusion frequency was variable. Some neonatal units did not report transfusion protocols. Most studies reported volumes of 10-15 ml/kg per transfusion. The implementation of an anemia care bundle and adoption of restrictive transfusion resulted in a reduction in the number of transfusions, the volume transfused, and a reduction in the rate of multiple transfusions. We suggest that neonatal units that care for preterm infants should have a transfusion protocol based on the best evidence available and this issue may improve.

A anemia é frequente nos bebês prematuros. As práticas de transfusão de glóbulos vermelhos variam entre os diferentes hospitais. O objetivo deste estudo foi revisar as práticas de transfusão de glóbulos vermelhos em bebês prematuros entre 2020 e 2021. Esta foi uma revisão narrativa que incluiu estudos publicados no PubMed (Medline) e Web of Science entre outubro de 2020 e outubro de 2021. Dez estudos foram definitivamente incluídos. A frequência de transfusão de glóbulos vermelhos foi variável. Algumas unidades neonatais não relataram protocolos de transfusão. A maioria dos estudos relatou volumes de 10-15 ml/kg por transfusão. A implantação de um conjunto de cuidados para anemia e a adoção de transfusão restritiva resultaram em uma redução do número de transfusões, do volume transfundido e uma redução na taxa de transfusões múltiplas. Sugerimos que as unidades neonatais que prestam cuidados a bebês prematuros devem ter um protocolo de transfusão baseado em evidências para que todo esse problema melhore.

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Objetivo: Relacionar las complicaciones y el riesgo de muerte en pacientes neurocríticos admitidos en la unidad de cuidados intensivos (UCI) del Hospital Universitario de Caracas durante un período de 5 meses. Métodos: investigación observacional, prospectiva, descriptiva. La muestra estuvo conformada por 65 pacientes neurocríticos, ≥ 18 años, con patologías médicas o quirúrgicas, ingresados en la UCI. El análisis estadístico incluyó la determinación de frecuencias, promedios, porcentajes y medias para descripción de variables y el T de Student. Resultados: La edad promedio fue 50,98 ± 16,66 años; la población masculinarepresentó el 50,76%. Entre las complicaciones, la mayor incidencia correspondió a las no infecciosas (70,77 %) y los trastornos ácido-básicos de tipo metabólico, la anemia y las alteraciones electrolíticas fueron las más frecuentes; el 29,23% de los pacientes presentaron complicaciones infecciosas, y la neumonía asociada a ventilación mecánica fue la más frecuente (73,91 %). La comorbilidad con mayor incidencia fue hipertensión arterial sistémica (53,84%). El 90.70% requirió ventilación mecánica y el tiempo en VM fue 4.29 ± 6.43 días. La estancia en UCI fue 5.96 ± 7.72 días. El 29,23% presentó un puntaje en la escala APACHE II entre 5-9; el SAPS II presentó mayor incidencia entre los 6-21 y 22-37 puntos con (66,70%); el SOFA al ingreso se reportó < 15 puntos en 98,46% y > 15 en 1,53%. La mortalidad del grupo fue 23,08 % (n=15). Conclusiones: Las complicaciones no infecciosas predominaron sobre las infecciosas las primeras íntimamente relacionadas con la mortalida(AU)

Objective: To relate complications and the risk of death in neurocritical patients admitted to the intensive care unit (ICU) of the University Hospital of Caracas during a period of 5 months. Methods: observational, prospective, descriptive research. The sample was made up of 65 neurocritical patients, ≥ 18 years old, with medical or surgical pathologies, admitted to the ICU.The statistical analysis included the determination of frequencies, averages, percentages and meansfor description of variables and Student's T.Results: The average age was 50.98 ± 16.66 years; the male population represented 50.76%. Among the complications, the highest incidence corresponded to non-infectious complications (70.77%) and metabolic acid-base disorders, anemia and electrolyte alterations were the most frequent; 29.23% of patients presented infectious complications, and pneumonia associated with mechanical ventilation was the most frequent (73.91%). The comorbidity with the highest incidence was systemic arterial hypertension (53.84%), 90.70% required mechanical ventilation and the time on MV was 4.29 ± 6.43 days. The ICU stay was 5.96 ± 7.72 days. 29.23% had a score on the APACHE II scale between 5-9; SAPS II presented the highest incidence between 6-21 and 22-37 points with (66.70%); The SOFA upon admission was reported to be < 15 points in 98.46% and > 15 in 1.53%. The mortality of the group was 23.08% (n=15). Conclusions: Non-infectious complications predominated over infectious complications, the former being closely related to mortalit(AU)

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La desnutrición ocurre cuando hay una ingesta o asimilación deficiente de la energía y los nutrientes. Si esta se produce dentro de los primeros años de vida, las consecuencias para la salud son devastadoras. El tratamiento temprano de la desnutrición es clave para reducir estas consecuencias y en este proceso la leche tiene una participación destacada. La leche es un excelente alimento debido al contenido y calidad de sus macro- y micronutrientes, lo que ha llevado a que la investigación y el uso de la leche en el tratamiento de la desnutrición hayan aumentado sostenidamente desde comienzos del siglo XX. En Chile, la desnutrición infantil fue prácticamente erradicada entre los años 1960 y 1980 debido a la aplicación exitosa de una serie de políticas públicas materno-infantiles, dentro de las cuales la Leche Purita fue fundamental. Sin embargo, la historia de la leche como parte de las políticas nutricionales en Chile comenzó mucho antes. Conmemorando los cincuenta años desde el nacimiento de Leche Purita, el objetivo de este trabajo es realizar un breve repaso acerca de la importancia histórica de la leche en las políticas nutricionales en Chile, enfatizando la contribución realizada por la Leche Purita a la erradicación de la desnutrición infantil y a la disminución de la anemia en niños.

Undernutrition occurs when there is poor intake or assimilation of energy and nutrients. If undernutrition is established within the first years of life, the health consequences are devastating. Early treatment of undernutrition is critical to reduce these consequences and milk plays an important role in this treatment. Cow's milk is an excellent food due to the content and quality of its macro- and micronutrients. This has led to a steady increase in research and the use of milk in treating undernutrition since the beginning of the 20th century. In Chile, child undernutrition was practically eradicated between the decades of 1960 and 1980 due to the successful application of maternal and child public policies, within which the product Leche Purita was fundamental. However, the history of milk as part of nutritional policies in Chile began much earlier. Commemorating fifty years since the introduction of Leche Purita, we aim to summarize the historical importance of milk in Chile's nutritional policies. We emphasize Leche Purita's role in eradicating child undernutrition and reducing anemia among children.

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Introducción: la terapia transfusional es un procedimiento terapéutico que ha contribuido a disminuir la mortalidad, y mejorar la calidad de vida de pacientes con diversas patologías. La utilización de guías en la práctica transfusional, contribuye a la utilización racional de las mismas. Objetivo: describir las características de los niños de 1 mes a 14 años 11 meses hospitalizados en el Centro Hospitalario Pereira Rossell durante el 2019 que recibieron transfusión de sangre desplasmatizada. Metodología: estudio descriptivo retrospectivo. Se incluyeron los niños entre 1 mes y 14 años 11 meses asistidos en emergencia, unidad de reanimación, cuidados moderados, intermedios e intensivos del Centro Hospitalario Pereira Rossell. Variables: edad, sexo, área de asistencia, motivo de ingreso, indicación de transfusión, cifras de Hb pre y post-transfusión, clasificación de la anemia, dosis. Resultados: se incluyeron 160 transfusiones correspondientes a 97 pacientes, 56% eran de sexo masculino. Media de edad 3 años, 52% < 1 año. El motivo de ingreso más frecuente fue patología respiratoria infecciosa 37%. El 79% fueron transfundidos en unidad de cuidados intermedios e intensivos. Media Hb pre-transfusión 7,45 g/dL y post-transfusión de 10,1 g/dL. Predominó la anemia moderada, normocítica-normocrómica, pura. La dosis media de sangre desplasmatizada transfundida fue 12 cc/kg. Conclusiones: en esta serie predominaron los pacientes de sexo masculino y menores a un año que ingresaron principalmente por patología respiratoria infecciosa. La mayoría de los pacientes transfundidos estaban en cuidados intensivos. Futuros estudios, de diseño prospectivo, que incluyan pacientes de todos los escenarios asistenciales y de otros prestadores de salud, contribuirán a continuar el estudio de los pacientes transfundidos y a la elaboración de recomendaciones o protocolos locales.

Introduction: Transfusion therapy is a therapeutic procedure that has contributed to reducing mortality and improving the quality of life of patients with various pathologies. The use of guides in transfusion practice contributes to their rational use. Objective: To describe the characteristics of children from 1 month to 14 years 11 months who were hospitalized in the Centro Hospitalario Pereira Rossell during 2019 who received a red blood cell transfusion. Methodology: Retrospective descriptive study. Children aged 1 month to 14 years and 11 months assisted in the emergency, moderate, intermediate and intensive care of the Centro Hospitalario Pereira Rossell were included in the study. Variables: age, sex, area of care, reason for admission, indication for transfusion, Hb figures before and after transfusion, classification of anaemia, dose. The study protocol was approved by the Institutional Ethics Committee. Results:160 transfusions corresponding to 97 patients were included, 56% were male. Mean age 3 years, 52% <1 year. The most frequent reason for admission was infectious respiratory disease 37%. 79% were transfused in the intermediate and intensive care unit. Mean Hb pre-transfusion 7.45 g/dL and post- transfusion of 10.1 g/dL. Moderate, normocytic-normochromic, pure anaemia predominated. The mean dose of deplasmatized blood transfused was 12 cc/kg. Conclusions: In this series, male patients less than one year of age predominated, admitted mainly for infectious respiratory disease. Most of the transfused patients were in intensive care. Future studies of prospective design that include patients from all healthcare settings and from other healthcare providers, will contribute to continuing the study of transfused patients and to the development of local recommendations or protocols.

Introdução: a terapia transfusional é um procedimento terapêutico que tem contribuído para reduzir a mortalidade e melhorar a qualidade de vida de pacientes com diversas patologias. A utilização de diretrizes na prática transfusional contribui para o seu uso racional. Objetivo: descrever as características das crianças de 1 mês a 14 anos e 11 meses internadas no Centro Hospitalario Pereira Rossell durante o ano de 2019 que receberam transfusão de sangue desplasmatizado. Metodologia: estudo descritivo retrospectivo. Foram incluídas crianças com idade entre 1 mês e 14 anos e 11 meses atendidas na emergência, unidade de reanimação, cuidados moderados, intermediários e intensivos do Centro Hospitalario Pereira Rossell. Variáveis: idade, sexo, área de atendimento, motivo da admissão, indicação de transfusão, valores de Hb pré e pós-transfusão, classificação da anemia, dose. Resultados: foram incluídas 160 transfusões correspondentes a 97 pacientes, 56% eram do sexo masculino. A idade média foi de 3 anos, 52% < 1 ano. O motivo mais frequente de admissão foi pato- logia respiratória infecciosa (37%). 79% foram transfundidos na unidade de tratamento intermediário e intensivo. Hb média pré-transfusional de 7,45 g/dL e Hb pós-transfusional de 10,1 g/dL. Predominou a anemia moderada, normocítica-normocrômica e pura. A dose média de sangue desplasmatizado transfundida foi de 12 cc/kg. Conclusões: nesta série, houve uma predominância de pacientes do sexo masculino com menos de um ano de idade que foram admitidos principalmente por patologia respiratória infecciosa. A maioria dos pacientes transfundidos estava em tratamento intensivo. Estudos prospectivos futuros incluindo pacientes de todos os ambientes de atendimento e outros presta- dores de serviços de saúde, contribuirão para um estudo mais aprofundado dos pacientes transfundidos e para o desenvolvimento de recomendações ou protocolos locais.

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OBJECTIVE@#Anemia is a common public health concern in patients with type 2 diabetes worldwide. This study aimed to identify the prevalence of anemia among patients with diabetes.@*METHODS@#Electronic databases, including PubMed, Scopus, Web of Sciences, and Google Scholar, were searched systematically for studies published between 2010 and 2021. After removing duplicates and inappropriate reports, the remaining manuscripts were reviewed and appraised using theNewcastle-Ottawa Scale (NOS) tool. A random-effects model was used to calculate the pooled estimates of the extracted data using Stata version 17. Heterogeneity of the studies was assessed using the Q statistic.@*RESULTS@#A total of 51 articles containing information on 26,485 patients with diabetes were included in this study. The articles were mainly from Asia (58.82%) and Africa (35.29%). The overall prevalence of anemia was 35.45% (95% CI: 30.30-40.76), with no evidence of heterogeneity by sex. Among the two continents with the highest number of studies, the prevalence of anemia in patients with diabetes was significantly higher in Asia [40.02; 95% CI: 32.72-47.54] compared to Africa [28.46; 95% CI: 21.90-35.50] ( P for heterogeneity = 0.029). Moreover, there has been an increasing trend in the prevalence of anemia in patients with diabetes over time, from [15.28; 95% CI: 9.83-22.21] in 2012 to [40.70; 95% CI: 10.21-75.93] in 2022.@*CONCLUSION@#Globally, approximately 4 in 10 patients with diabetes suffer from anemia. Therefore, routine anemia screening and control programs every 3 months might be useful in improving the quality of life of these patients.

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PURPOSE@#Dabigatran is usually prescribed in recommended doses without monitoring of the blood coagulation for the prevention of venous thromboembolism after joint arthroplasty. ABCB1 is a key gene in the metabolism of dabigatran etexilate. Its allele variants are likely to play a pivotal role in the occurrence of hemorrhagic complications.@*METHODS@#The prospective study included 127 patients with primary knee osteoarthritis undergoing total knee arthroplasty. Patients with anemia and coagulation disorders, elevated transaminase and creatinine levels as well as already receiving anticoagulant and antiplatelet therapy were excluded from the study. The association of ABCB1 gene polymorphisms rs1128503, rs2032582, rs4148738 with anemia as the outcome of dabigatran therapy was evaluated by single-nucleotide polymorphism analysis with a real-time polymerase chain reaction assay and laboratory blood tests. The beta regression model was used to predict the effect of polymorphisms on the studied laboratory markers. The probability of the type 1 error (p) was less than 0.05 was considered statistically significant. BenjaminiHochberg was used to correct for significance levels in multiple hypothesis tests. All calculations were performed using Rprogramming language v3.6.3.@*RESULTS@#For all polymorphisms there was no association with the level of platelets, protein, creatinine, alanine transaminase, prothrombin, international normalized ratio, activated partial thromboplastin time and fibrinogen. Carriers of rs1128503 (TT) had a significant decrease of hematocrit (p = 0.001), red blood count and hemoglobin (p = 0.015) while receiving dabigatran therapy during the postoperative period compared to the CC, CT. Carriers of rs2032582 (TT) had a significant decrease of hematocrit (p = 0.001), red blood count and hemoglobin (p = 0.006) while receiving dabigatran therapy during the postoperative period compared to the GG, GT phenotypes. These differences were not observed in carriers of rs4148738.@*CONCLUSION@#It might be necessary to reconsider thromboprophylaxis with dabigatran in carriers of rs1128503 (TT) or rs2032582 (TT) polymorphisms in favor of other new oral anticoagulants. The long-term implication of these findings would be the reduction of bleeding complications after total joint arthroplasty.

ABSTRACT

Introducción: el hidrops fetal es grave, de mal pronóstico y alta morbimortalidad, a pesar de mejoras diagnósticas y terapéuticas desarrolladas en los últimos tiempos. El pronóstico estará determinado por la etiología y posibilidades terapéuticas asociadas a mejores resultados, a la edad gestacional, al diagnóstico y al nacimiento, si bien cabe destacar que no existen suficientes estudios de seguimiento a largo plazo. El diagnóstico ecográfico es confirmatorio, siendo la principal complejidad identificar la etiología y plantear la estrategia terapéutica adecuada. Descripción del caso: presentamos una paciente con diagnóstico de hidrops fetal de tipo no inmune y su abordaje terapéutico. La causa del hidrops correspondió a anemia fetal severa, requiriendo la realización de tres procedimientos con exanguinotransfusión parcial intrauterina mediante cordocentesis. A las 33 semanas, se decidió la finalización del embarazo, con buena evolución neonatal. Conclusión: el hidrops fetal aumenta la morbimortalidad fetal y neonatal, siendo un enorme desafío para el equipo tratante, que requiere de un equipo asistencial interdisciplinario. El conocimiento de esta patología permite realizar un abordaje completo, orientar a la etiología, realizando un diagnóstico oportuno y la selección adecuada del tratamiento. Como en este caso, al identificar la anemia severa como causa del hidrops, es mandatorio definir el manejo para los fetos candidatos a terapia intrauterina.

Introduction: fetal hydrops is a serious condition with a poor prognosis and high morbidity and mortality, despite improvements in diagnostics and therapeutics in recent years. Prognosis is determined by the etiology and therapeutic options associated with better outcomes, gestational age, diagnosis, and birth, although it should be noted that there are not enough long-term follow-up studies. Ultrasound diagnosis is confirmatory, with the main challenge being to identify the etiology and propose the appropriate therapeutic strategy. Description of the case: we present a patient diagnosed with non-immune fetal hydrops and its therapeutic approach. The cause of hydrops was severe fetal anemia, requiring 3 procedures with intrauterine partial exsanguination transfusion through Cordocentesis. At 33 weeks, the decision was made to terminate the pregnancy, with good neonatal outcomes. Conclusions: fetal hydrops increases fetal and neonatal morbidity and mortality, posing a significant challenge for the treating team and requiring an interdisciplinary healthcare team. Understanding this condition allows for a comprehensive approach, guiding the etiology, providing timely diagnosis, and selecting appropriate treatment. As in this case, identifying severe anemia as the cause of hydrops mandates defining the management for fetuses eligible for intrauterine therapy.

Introdução: a hidropisia fetal é grave, com mau prognóstico e elevada morbimortalidade, apesar das melhorias diagnósticas e terapêuticas desenvolvidas nos últimos tempos. O prognóstico será determinado pela etiologia e possibilidades terapêuticas associadas a melhores resultados, idade gestacional, diagnóstico e nascimento, embora se deva salientar que não existem estudos suficientes de seguimento a longo prazo. O diagnóstico ultrassonográfico é confirmatório, sendo a principal complexidade identificar a etiologia e propor a estratégia terapêutica adequada. Descrição do caso: apresentamos uma paciente com diagnóstico de hidropisia fetal não imune e sua abordagem terapêutica. A causa da hidropisia correspondeu a anemia fetal grave, sendo necessária a realização de 3 procedimentos com exsanguineotransfusão intrauterina parcial por meio de cordocentese. Às 33 semanas foi decidida a interrupção da gravidez, com boa evolução neonatal. Conclusão: a hidropisia fetal aumenta a morbimortalidade fetal e neonatal, sendo um enorme desafio para a equipe responsável pelo tratamento, necessitando de uma equipe de atendimento interdisciplinar. O conhecimento desta patologia permite uma abordagem completa, orientação sobre a etiologia, diagnóstico atempado e seleção do tratamento adequado. Assim como neste caso, quando se identifica anemia grave como causa da hidropisia, é obrigatória a definição do manejo para os fetos candidatos à terapia intrauterina.

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Abstract Postoperative anemia is a complex clinical issue that requires attention due to its ramifications on the patient's recovery and prognosis. Originating from multiple determinants, such as intraoperative blood loss, hemolysis, nutritional deficiencies, systemic inflammation and impact on the bone marrow, postoperative anemia has varied and often challenging presentations. Patients undergoing major surgical procedures, in particular, are susceptible to developing anemia due to the considerable associated blood loss. Accurate diagnosis plays a crucial role in the approach, requiring meticulous hematological analysis, including hemoglobin, hematocrit and reticulocyte count, as well as an in-depth investigation of the underlying causes. An additional challenge arises in the form of the excessive practice of phlebotomy during hospitalization for clinical monitoring. Although it is essential to assess the progression of anemia, frequent removal of blood may contribute to iatrogenic anemia, further delaying recovery and possibly increasing susceptibility to infection.

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Abstract Managing coagulation disorders and potential bleeding risks, especially in the context of anticoagulant medications, is of immense value both clinically and prior to surgery. Coagulation disorders can lead to bleeding complications, affecting patient safety and surgical outcomes. The use of Patient Blood Management protocols offers a comprehensive, evidence-based approach that effectively addresses these challenges. The problem is to find a delicate balance between preventing thromboembolic events (blood clots) and reducing the risk of bleeding. Anticoagulant medications, although crucial to preventing clot formation, can increase the potential for bleeding during surgical procedures. Patient blood management protocols aim to optimize patient outcomes by minimizing blood loss and unnecessary transfusions.

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Introducción: La anemia en niños, especialmente en menores de tres años, es un importante problema de salud pública en el mundo y en el Perú. Objetivo: Identificar los determinantes sociales que expliquen la desigualdad sociogeográfica en la distribución de la prevalencia de anemia en niños peruanos de 6 a 35 meses. Métodos: Se realizó un estudio observacional, ecológico y analítico en 26 gobiernos subnacionales del Perú. Se aplicaron pruebas de correlación, regresión lineal simple y múltiple, así como el cálculo de las brechas y gradientes de desigualdad. Resultados: La proporción de gestantes sin suplementación de hierro fue la única variable explicativa de la prevalencia de anemia en niños en la muestra evaluada. El gradiente absoluto de desigualdad reflejó un patrón de equidad (ICD = 0.02) con exceso de prevalencia de anemia en niños de 6 a 35 meses equivalente a 11.53% a lo largo del gradiente determinado por la proporción de gestantes sin suplementación de hierro y mayor impacto en los territorios ubicados en el quintil con mayor proporción de gestantes sin suplementación de hierro, en términos absolutos y relativos (18.49% y 1.46%; respectivamente). Conclusiones: La proporción de gestantes sin suplementación de hierro explicaría la brecha de desigualdad sociogeográfica en la distribución de la prevalencia de anemia en niños peruanos de 6 a 35 meses de tipo marginal. Los territorios con menor logro de este indicador estarían expuestos a mayor prevalencia de anemia, por lo que se requerirían que las intervenciones universales sean focalizadas en ellos.

Background: Anemia in children is a major public health problem in the world and Perú, especially in those under three years old. Aim: The study was designed to identify the social determinants that explain the socio-geographic inequality in the distribution of anemia prevalence in six-to-35-month Peruvian children. Methods: An observational, ecological, and analytic study was carried out in 26 subnational governments of Peru. Correlation tests, simple and multiple linear regression, and calculating inequality gaps and gradients were applied. Results: The proportion of pregnant women without iron supplementation was the only explanatory variable for the prevalence of anemia in children under 36 months. The absolute gradient of inequality reflected a pattern of equity (ICI = 0.02). Excess of anemia prevalence in six-to-35-month children was equivalent to 11.53% along the gradient determined by the proportion of pregnant women without iron supplementation. Territories in the quintile with the highest proportion of pregnant women without iron supplementation had the highest gap in absolute and relative terms (18.49% and 1.46%; respectively). Conclusions: The proportion of pregnant women without iron supplementation would explain the socio-geographic inequality gap in the prevalence of anemia in 6-to-35-month Peruvian children. In other words, territories with the lowest achievement of this indicator would be exposed to a higher prevalence of anemia, so universal interventions must be focused on them.

ABSTRACT

Introducción: La anemia posoperatoria es una complicación importante en pacientes sometidos a una artroplastia total de cadera (ATC). El objetivo principal de este estudio fue evaluar la prevalencia de anemia posoperatoria en pacientes sometidos a una ATC programada y determinar si está relacionada con el tratamiento tromboprofiláctico administrado. Materiales y Métodos: Ensayo prospectivo aleatorizado. Se incluyó a 358 pacientes sometidos a una ATC programada entre febrero de 2019 y enero de 2022, que fueron divididos en 3 grupos para recibir: rivaroxabán 10 mg, enoxaparina sódica 40 mg o aspirina 100 mg como estrategia de tromboprofilaxis diaria. Resultados: No hubo casos de enfermedad tromboembólica confirmada ni de hemorragia grave. Los niveles de hemoglobina y hematocrito fueron similares en todos los grupos de tratamiento, sin diferencias estadísticamente significativas. No se hallaron diferencias en la incidencia de complicaciones. La suplementación con hierro fue significativamente mayor en el grupo de enoxaparina (p = 0,041). La incidencia de anemia en el modelo de regresión ordinal se asoció con la edad (OR 1,02; IC95% 1,00-1,05; p 0,04), el sexo masculino (OR 0,33; IC95% 0,19-0,56; p <0,01) y la presencia de una comorbilidad (OR 0,49; IC95% 0,28-0,85; p 0,012). Conclusiones: La tromboprofilaxis utilizada no tiene impacto en el desarrollo de la anemia posoperatoria en pacientes sometidos a una ATC. El sexo masculino, la edad y la presencia de alguna comorbilidad parecen ser los factores que influyen negativamente en la anemia. No hubo diferencias significativas en el perfil de seguridad de estas tres terapias de tromboprofilaxis. Nivel de Evidencia: II

Background: Postoperative anemia is a significant complication in patients undergoing total hip arthroplasty (THA). The primary objective of this study was to evaluate the prevalence of postoperative anemia in patients undergoing elective THA and to determine whether there is a relationship with the thromboprophylactic treatment used. Materials and Methods: This was a prospective randomized trial. A total of 358 patients who underwent elective THA between February 2019 and January 2022 were included. Patients were divided into three groups receiving daily thromboprophylaxis: rivaroxaban 10 mg, enoxaparin sodium 40 mg, or aspirin 100 mg. Results: No confirmed cases of thromboembolic disease or severe bleeding were reported. Hemoglobin and hematocrit levels were consistent across all treatment groups, with no statistically significant differences. There were no differences in complication rates among the groups. However, iron supplementation was significantly higher in the enoxaparin group (p = 0.041). In the ordinal regression model, the incidence of anemia was associated with age (OR 1.02, 95% CI 1.00-1.05, p = 0.04), male sex (OR 0.33, 95% CI 0.19-0.56, p < 0.01), and the presence of any comorbidity (OR 0.49, 95% CI 0.28-0.85, p = 0.012). Conclusions: The thromboprophylaxis treatments evaluated in this study had no impact on the development of postoperative anemia in patients undergoing THA. Male sex, age, and the presence of comorbidities appear to be the factors most negatively influencing the development of anemia. No significant differences were found in the safety profiles of the three thromboprophylaxis therapies. Level of Evidence: II