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1.
Braz. j. oral sci ; 20: e211512, jan.-dez. 2021. ilus
Article in English | LILACS, BBO | ID: biblio-1254424

ABSTRACT

Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated the potential of host defense peptides clavanins A, MO, and LL-37 in in vitro osteoclastogenesis. Methods: RAW 264.7 cultures were stimulated with recombinant of receptor activator of nuclear factor kappa B ligand in the presence of different tested concentrations of host defense peptides, besides calcium hydroxide and doxycycline. Cellular viability, nitric oxide production, and a number of differentiated osteoclast-like cells were also evaluated. Results: Results showed that none of the substances were cytotoxic, except for 128 µg.mL-1 of doxycycline after 3 days. Host defense peptides, calcium hydroxide, and doxycycline did not interfere in nitric oxide production or downregulated it. An exception was observed in the presence of 2 µg.mL-1 of doxycycline, in which nitric oxide production was up-regulated. All host defense peptides were capable of reducing osteoclast-like cell differentiation. Conclusion: Host defense peptides clavanins A and MO demonstrated to be potential suppressors of osteoclastogenesis in vitro without interfering in cellular viability and nitric oxide production. These promising results need to be further analyzed in in vivo models of bone resorption


Subject(s)
Osteogenesis , Bone Resorption , Antimicrobial Cationic Peptides , Nitric Oxide
2.
Rev. cuba. estomatol ; 58(3): e3073, 2021. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1347440

ABSTRACT

Introducción: El posicionamiento de implantes dentales simultáneos a la elevación de seno maxilar en rebordes con reabsorción severa < 4mm es una técnica quirúrgica sensible que disminuye los tiempos operatorios. Sin embargo, es considerada cirujano-dependiente y en caso de no darse el manejo adecuado puede generar complicaciones. Objetivo: Evaluar, luego de 24 meses de carga funcional, la estabilidad de los tejidos periimplantares del implante dental que se posicionó simultáneo a la elevación de seno maxilar en un reborde alveolar con reabsorción ósea severa < 4mm. Presentación de caso: Paciente masculino de 62 años con reabsorción ósea severa en zona de primer molar superior derecho. Luego de analizar los medios diagnósticos y la evidencia científica; se logró posicionar un implante dental simultáneo a la elevación de seno maxilar técnica de ventana lateral; cuatro meses después se realizó la segunda fase quirúrgica y finalmente fue rehabilitado con una corona en zirconio. Tuvo un periodo de seguimiento de 24 meses. Conclusiones: Un buen diagnóstico, manejo quirúrgico adecuado, la colaboración del paciente y los controles periódicos, resultan en una técnica segura, que proporciona estabilidad de los tejidos periimplantares(AU)


Introduction: Dental implant placement simultaneous with maxillary sinus lifting on ridges with severe resorption < 4 mm is a sensitive surgical technique that shortens the duration of interventions. However, it is considered to be operator dependent, and may cause complications if not appropriately managed. Objective: After 24 months of functional load, evaluate the stability of the peri-implant tissue of a dental implant placed simultaneously with maxillary sinus lifting on an alveolar ridge with severe bone resorption. Case presentation: A case is presented of a male 62-year-old patient with severe bone resorption in the area of the first upper right molar. Analysis of the diagnostic means and scientific evidence involved led to placement of a dental implant simultaneous with maxillary sinus lifting (lateral window technique). The second surgical stage was performed four months later. A zirconium crown was finally placed, and a 24-month follow-up period was started. Conclusions: With a good diagnosis, appropriate surgical management, patient cooperation and periodic controls, it is a safe technique that ensures the stability of peri-implant tissue(AU)


Subject(s)
Humans , Male , Middle Aged , Bone Resorption/diagnosis , Dental Implants/adverse effects , Maxillary Sinus/surgery , Aftercare
3.
Article in English | WPRIM | ID: wpr-879968

ABSTRACT

To investigate the effects of interleukin (IL)-17-mediated autophagy on the TNF receptor associated factor (TRAF6)/extracellular signal-regulated kinase (ERK)/p38 pathway and osteoclast differentiation. Mouse bone marrow-derived macrophages (BMM) were cultured with a medium containing 30 ng/mL macrophage colony stimulating factor and 50 ng/mL receptor activator of nuclear factor-kappa B ligard (RANKL), and IL-17 (0.01, 0.1, 1.0, 10 ng/mL) was added for intervention (IL-17 group). Tartrate-resistant acid phosphatase (TRAP) staining was used to observe TRAP positive multinucleated cells; phalloidin fluorescent staining was used to detect actin ring circumference; toluidine blue staining was used to analyze bone resorption lacuna formation. To further examine the mechanism of the effect of IL-17-mediated autophagy on the differentiation of osteoclasts, the control group used RANKL medium to culture mouse macrophage RAW264.7 cells, while the IL-17 group was treated with IL-17 (0.01, 0.1, 1.0, /mL). Western blot was used to detect the expression of autophagy-related proteins Beclin-1, microtubule-associated protein 1 light chain 3 (LC3) and osteoclast-related proteins c-fos and nuclear factor of activated T cell 1 (NFATc1) after treatment with different concentrations of IL-17. The expression of LC3, NFATc1, TRAF6/ERK/p38 signaling pathway related proteins were detected in IL-17 and autophagy inhibitor 3-MA group. The number of TRAP positive multinucleated cells, the circumference of the actin ring and the area of bone resorption lacuna in IL-17 group treated with IL-17 (0.01, 0.1, were significantly higher than those in the control group. In IL-17 treated RAW264.7 cells, the expression of c-fos, NFATc1, Beclin-1, LC3, TRAF6, p-ERK, and p-p38 was all significantly up-regulated (all 0.05). After treatment with the autophagy inhibitor 3-MA, the expression levels of LC3, NFATc1, TRAF6, p-ERK, and p-p38 all decreased significantly (all 0.05). IL-17 can promote the expression of autophagy proteins and enhance the differentiation ability of osteoclast precursor cells, and the TRAF6/ERK/p38 signaling pathway may be involved in this process.


Subject(s)
Animals , Autophagy , Bone Resorption , Cell Differentiation , Extracellular Signal-Regulated MAP Kinases , Interleukin-17 , Mice , NFATC Transcription Factors/metabolism , Osteoclasts/metabolism , RANK Ligand/metabolism , TNF Receptor-Associated Factor 6
4.
Article in Chinese | WPRIM | ID: wpr-888319

ABSTRACT

Parathyroid hormone is one kind of osteoanabolic agents widely used in clinic for osteoporosis. However, parathyroid hormone needs to be further optimized in the treatment of osteoporosis due to its two way regulatory effect of bone formation with low-dose intermittent treatmentand bone resorption with high-dosecontinuous treatment. Hence, based on the molecular mechanism of parathyroid hormone regulating bone metabolism, we conclude that parathyroid hormone regulates bone metabolism mainly through the following signaling pathways: (1) Gs/cAMP/PKA signaling pathway, whichis the main mechanism of parathyroid hormone regulating bone metabolism to lead to bone formation or bone resorption. (2) G


Subject(s)
Bone Resorption , Humans , Osteogenesis , Osteoporosis , Parathyroid Hormone , Signal Transduction
5.
Article in English | WPRIM | ID: wpr-922463

ABSTRACT

Guided bone regeneration (GBR) uses resorbable and non-resorbable membranes as biological barriers. This study compared the differences in hard tissue stability between GBR using evidence-based digital titanium mesh and resorbable collagen membranes during implant placement. A total of 40 patients (65 implant sites) were enrolled and divided into two groups: resorbable membrane and digital titanium mesh groups. The alveolar bone was analyzed at two- and three-dimensional levels using cone-beam computed tomography and by reconstructing and superimposing the hard tissues at four time points: preoperatively, postoperatively, before second-stage surgery, and 1 year after loading. The use of digital titanium mesh showed less alveolar bone resorption in vertical and horizontal directions two-dimensionally before the second-stage surgery and 1 year after loading. Regarding volumetric stability, the percentage of resorption after 6 months of healing with resorbable membrane coverage reached 37.5%. However, it was only 23.4% with titanium mesh. Although postoperative bone volume was greater at all labial sites with resorbable membrane than with digital titanium mesh, after substantial bone resorption within 1 year of loading, the labial bone thickness at the upper part of implants was thinner with resorbable membrane than with digital titanium mesh. Furthermore, digital titanium meshes made according to ideal bone arch contour reduced soft tissue irritation, and the exposure rate was only 10%. Therefore, although both resorbable membrane and digital titanium mesh in GBR were able to successfully reconstruct the bone defect, digital titanium meshes were better at maintaining the hard tissue volume in the osteogenic space.


Subject(s)
Bone Regeneration , Bone Resorption , Humans , Osteogenesis , Surgical Mesh , Titanium
6.
Article in Chinese | WPRIM | ID: wpr-878434

ABSTRACT

Bone invasion by oral cancer is a common clinical problem, which affects the choice of treatment and predicts a poor prognosis. Unfortunately, the molecular mechanism of this phenomenon has not been fully elucidated. Current studies have revealed that oral cancer cells modulate the formation and function of osteoclasts through the expression of a series of signal molecules. Many signal pathways are involved in this process, of which receptor activator of nuclear factor-κB ligand/receptor activator of nuclear factor-κB/osteoprotegerin signaling pathway attracted much attention. In this review, we introduce recent progress in molecular mechanisms of bone invasion by oral cancer.


Subject(s)
Bone Resorption , Bone and Bones , Humans , Mouth Neoplasms , Osteoclasts , Osteoprotegerin , RANK Ligand , Receptor Activator of Nuclear Factor-kappa B
7.
Article in Chinese | WPRIM | ID: wpr-878423

ABSTRACT

OBJECTIVES@#This study aimed to explore the changes in the expression of the characteristic transcription factor retinoid related orphan receptor γt (RORγt) and the cytokine interleukin-17 (IL-17) of T helper cell 17 (Th17) in the pressure side of the periodontal tissue of rats under different orthodontic forces. Their effects on the expression of osteoprotegerin (OPG) and the quantity of osteoclast (OC) were also explored. The role of Th17 cell in alveolar bone remodeling under different forces was preliminarily investigated.@*METHODS@#A total of 108 rats were chosen and randomly divided into three groups. Mesial forces of 0, 50, and 100 g were loaded on the maxillary first molar in the three groups. The rats were executed at 0, 1, 3, 5, 7, and 14 days. The expression of RORγt mRNA was quantified by real-time quantitative polymerase chain reaction. The expression of IL-17 protein was quantified by enzyme linked immunosorbent assay. The expression levels of RORγt and OPG proteins were quantified, and the quantity of OC was counted via immunohistochemistry.@*RESULTS@#The expression levels of RORγt and IL-17 and the quantity of OC increased first and then decreased in the 50 and 100 g groups, and the peak values of the two groups were on days 5 and 7, respectively. The expression levels in the 50 g group basically recovered to normal level on day 14, while that in the 100 g group remained at a high level. The expression levels in the 50 g group were higher than those in the 0 g group and lower than those in the 100 g group. The expression of OPG in the 50 g group decreased first, then increased, and finally decreased. It basically recovered to normal level on day 14. The expression of OPG in the 100 g group decreased first and then increased. It remained at a high level on day 14. The expression in the 50 g group was significantly higher than that in the 0 g group on day 7, while the expression in the 100 g group was significantly higher than that in the 0 g group on day 14.@*CONCLUSIONS@#RORγt, IL-17, and OPG were expressed regularly over time under different orthodontic forces, indicating that Th17 participated in the process of bone resorption on the pressure side of periodontal tissue by secreting IL-17.


Subject(s)
Animals , Bone Resorption , Cytokines , Interleukin-17 , Molar , Nuclear Receptor Subfamily 1, Group F, Member 3 , Osteoclasts , Osteoprotegerin , Rats , Th17 Cells , Tooth Movement Techniques
8.
São José dos Campos; s.n; 2021. 107 p. ilus, graf, tab.
Thesis in Portuguese | LILACS, BBO | ID: biblio-1362411

ABSTRACT

O objetivo deste estudo foi analisar os efeitos do estresse crônico sobre a periodontite apical (PA) induzida em ratos, e avaliar os efeitos do uso da Fluoxetina (antidepressivo da classe dos inibidores da recaptação de serotonina) e do Propranolol (bloqueador beta-adrenérgico), associados ou não, na modulação inflamatória e na reabsorção óssea periapical de ratos estressados. Foram utilizados 40 ratos divididos em cinco grupos: Grupo controle não-estressado (NS); Grupo controle estressado com administração de solução fisiológica (SS); Grupo estressado com administração de Fluoxetina (SF); Grupo estressado com administração de Propranolol (SP); Grupo estressado com administração de Fluoxetina e Propranolol (SFP). Os animais dos grupos estressados foram submetidos ao protocolo de estresse crônico imprevisível durante 6 semanas e as respectivas medicações foram administradas diariamente, via gavagem, ao longo de todo o período experimental. A PA foi induzida em todos os grupos após 21 dias do início do protocolo de estresse e ao final da 6ª semana, os animais foram eutanasiados e as hemimandíbulas e hemimaxilas removidas. Posteriormente foram realizadas as seguintes análises: a) da massa corporal; b) dos níveis séricos de corticosterona por radioimunoensaio; c) dos níveis séricos hormonais e inflamatórios por ensaio Multiplex; e) histomorfométrica por coloração com hematoxilina e eosina; f) da estrutura óssea periapical através de microtomografia computadorizada (micro-CT); g) da expressão gênica de biomarcadores relacionados à atividade osteoclástica, citocinas inflamatórias e metaloproteinases na região periapical por RT-PCR. Ao final do experimento os animais estressados apresentaram menor ganho de massa corporal, níveis séricos de ACTH significativamente mais altos, atividade inflamatória mais intensa e maiores volumes de lesão periapical quando comparados aos animais do grupo controle NS. Os grupos tratados SF, SP e SFP apresentaram menores volumes de lesão periapical quando comparados ao grupo controle SS, e o grupo SP apresentou menor intensidade do infiltrado inflamatório. O teste de RT-PCR mostrou maior expressão de RANKL e TRAP no grupo controle SS, bem como maior expressão de IL-6, IL-10 e IL-17 e MMP-8 quando comparado ao grupo controle NS. Na comparação em relação ao grupo controle SS, o grupo SF apresentou maior expressão de OPG, e menor expressão de IL-6 e IL-17; o grupo SP apresentou maior expressão de OPG e menor expressão de IL-6, IL-10, IL-17, MMP-8 e MMP-13, e o grupo SFP apresentou menor expressão de RANKL, TRAP, IL-6, IL-10, IL-17, MMP-8 e MMP-13. Foi concluído que o estresse crônico influenciou negativamente a patogênese da PA e ambos os medicamentos avaliados, bem como sua associação, tiveram efeitos positivos na prevenção da perda óssea e modulação inflamatória.


The aim of this study was to analyze the effects of chronic stress on induced apical periodontitis (AP) in rats, and to evaluate the effects of the use of fluoxetine (antidepressant known as selective serotonin reuptake inhibitor), and of Propranolol (beta-adrenergic blocker), associated or not, in inflammatory modulation and periapical bone resorption in stressed rats. Forty rats were divided into five groups: Unstressed control group (NS); Stressed control group with saline solution administration (SS); Stressed group with administration of Fluoxetine (SF); Stressed group with administration of Propranolol (SP); Stressed group with administration of Fluoxetine and Propranolol (SFP). The animals in the stressed groups were submitted to the unpredictable chronic stress paradigm for 6 weeks and the respective medications were administered daily, via gavage, throughout the entire experimental period. AP was induced in all groups, 21 days after the beginning of the stress paradigm, and at the end of the 6th week, the animals were euthanized and the hemi-mandibles removed for the following analyses: a) body weight b) serum corticosterone levels by radioimmunoassay; c) hormone and inflammatory serum levels by Multiplex assay; e) histomorphometric staining with hematoxylin and eosin; f) the periapical bone structure through computerized microtomography; g) gene expression related to osteoclastic activity, inflammatory cytokines and metalloproteinases in the periapical region by RT-PCR. At the end of the experiment, the stressed animals showed lower body weight gain, significantly higher levels of ACTH, more intense inflammatory infiltrate and higher volumes of periapical lesion when compared to animals in the NS control group. The treated groups SF, SP and SFP had smaller volumes of periapical lesion when compared to the SS control group and the SP group had lower intensity of inflammatory infiltrate. The RT-PCR test showed higher expression of RANKL and TRAP in the stressed control group, as well as higher expression of IL-6, IL-10, IL-17 and MMP-8 when compared to the NS control group. In comparison with the SS control group, the SF group showed higher expression of OPG, and lower expression of IL-6 and IL-17; the SP group showed higher expression of OPG and lower expression of IL-6, IL-10, IL-17, MMP-8 and MMP-13 and the SFP group showed lower expression of RANKL, TRAP, IL-6, IL-10, IL-17, MMP-8 and MMP-13. It was concluded that chronic stress negatively influenced the pathogenesis of apical periodontitis and both medications evaluated, as well as its association, had positive effects in preventing bone loss and inflammatory modulation.


Subject(s)
Animals , Rats , Periapical Periodontitis , Stress, Physiological , Serotonin Uptake Inhibitors , Adrenergic beta-Antagonists , Propranolol , Bone Resorption , Fluoxetine , Analysis of Variance , Statistics, Nonparametric , Euthanasia, Animal
9.
Braz. dent. sci ; 24(4, suppl 1): 1-8, 2021. tab, ilus
Article in English | LILACS, BBO | ID: biblio-1352634

ABSTRACT

Objective: Investigating osteopontin (OPN) level in gingival crevicular fluid (GCF) of patients affected by periodontitis with or without Type-2 diabetes mellitus (T2DM). The aim of this study is to explore the possibility of OPN to differentiate between periodontal health and disease. Material and Methods: A total number of 36 participants seeking periodontal treatment were recruited in this pilot study and divided into three study groups. Periodontitis [systemically healthy participants with periodontitis (probing pocket depth) PPD (probing pocket depth) ≥ 4mm], periodontitis and poorly controlled type 2 diabetes mellitus (), and control (systemically and periodontally healthy periodontium) groups. Plaque index (PI), gingival index (GI) and PPD were examined. OPN level was measured in the GCF and analysed, using Enzyme-Linked Immunosorbent assay. Results: PI and GI were significantly higher in T2DM with periodontitis compared to periodontitis and control groups. Both periodontitis and P-T2DM groups showed significant increase in the OPN levels compared to control group (p<0.001). PPD showed the only significant positive association with OPN (p<0.001) compared to other clinical parameters. The receiver operating characteristics curve analysis demonstrated that OPN had higher area under the curve value (AUC: 0.95) in periodontitis compared to P-T2DM patients (AUC: 0.86). Conclusion: In periodontitis groups, clinical parameters were equally deteriorated together with significant increase in the expression of OPN compared to control. Furthermore, GCF levels of OPN were sensitive and specific enough to discriminate between health and periodontitis even with T2DM. This could introduce OPN to be as a candidate diagnostic biomarker of periodontal disease. (AU)


Objetivo: Investigar o nível de osteopontina (OPN) no fluido gengival crevicular (GCF) de pacientes com periodontite com ou sem diabetes mellitus tipo 2 (T2DM). O objetivo deste estudo foi explorar a possibilidade da OPN diferenciar entre saúde e doença periodontal. Material e Métodos: No total, para este estudo piloto foram recrutados 36 participantes que estavam em busca de tratamento periodontal e divididos em três grupos de estudo: grupos periodontite [participantes sistemicamente saudáveis com periodontite (profundidade de sondagem) PPD ≥ 4 mm], grupo periodontite e Diabetes Mellitus tipo 2 mal controlada (P-T2DM) e grupo controle (saudáveis sistemicamente e periodontalmente). Índice de placa (PI), índice gengival (GI) e PPD foram examinados. O nível de OPN foi medido no GCF e analisado usando o ensaio ELISA (Enzyme-Linked Immuno Sorbent Assay). Resultados: PI e GI foram significativamente maiores no T2DM com periodontite em comparação aos grupos com periodontite e controle. Os grupos com periodontite e P-T2DM apresentaram aumento significativo nos níveis de OPN em comparação ao grupo controle (p <0,001). PPD mostrou a única associação positiva significativa com OPN (p <0,001) em comparação com outros parâmetros clínicos. A análise da curva de características operacionais do receptor demonstrou que OPN teve maior área sob o valor da curva (AUC: 0,95) na periodontite em comparação com pacientes com P-T2DM (AUC: 0,86). Conclusão: Nos grupos com periodontite, os parâmetros clínicos foram igualmente deteriorados juntamente com aumento significativo na expressão de OPN em comparação com o grupo controle. Além disso, os níveis de OPN no GCF foram sensíveis e específicos o suficiente para discernir entre saúde e periodontite, mesmo com T2DM. Isso poderia apresentar a OPN como um candidato a biomarcador diagnóstico de doença periodontal.(AU)


Subject(s)
Humans , Periodontitis , Bone Resorption , Diabetes Mellitus, Type 2 , Osteopontin
10.
Braz. oral res. (Online) ; 35: e27, 2021. tab, graf
Article in English | LILACS, BBO | ID: biblio-1153614

ABSTRACT

Abstract The aim of the present overview was to evaluate the outcomes of systematic reviews to determine the incidence of condylar resorption in patients submitted to orthognathic surgery and analyze whether the risk of developing this condition is related to a specific type of surgery. Searches were conducted in the PubMed/MEDLINE, Embase, and Cochrane electronic databases for systematic reviews with quantitative data on condylar resorption due to any type of orthognathic surgery for dentoskeletal deformities published up to May 25, 2019. The AMSTAR 2 and Glenny tools were applied for the quality appraisal. Five systematic reviews were included for analysis. Only one article was considered to have high quality. Among a total of 5128 patients, 12.32% developed condylar resorption. From those patients, 70.1% had double jaw surgery, 23.4% had mandibular surgery alone, and in 6.5% a Lefort I technique was used. Based on these findings, bimaxillary surgery could be considered a risk factor for condylar resorption. However, these results should be interpreted with caution, since other factors, such as pre-operative skeletal deformities, type of movement, and type of fixation, can contribute to the development of this condition. Further studies should consider reporting main cephalometric data, temporomandibular diagnosis, hormonal levels, and tomographic measures before and after the surgery at least every 6 months during the firsts two years to identify accurately risk factors for condylar resorption.


Subject(s)
Humans , Bone Resorption/etiology , Bone Resorption/epidemiology , Orthognathic Surgical Procedures , Cephalometry , Incidence , Systematic Reviews as Topic , Mandibular Condyle/surgery
11.
São José dos Campos; s.n; 2021. 81 p. il., tab., graf..
Thesis in Portuguese | LILACS, BBO | ID: biblio-1255006

ABSTRACT

Embora existe um alto índice de sucesso implantes dentários, podem ocorrer perda da osseintegração após instalação das próteses sobre implante e as causas são as periimplantites e sobre cargas oclusais. Diferentes conexõessurgiram para o melhor desempenho estético, biomecânico e para evitar perdas ósseas perimplantares. Para analisar às deformações geradas ao redor dos implantes e suas conexões, as duas metodologias utilizadas neste estudo e que apresentam resultados numéricos,foram a análise de elementos finitos e a extensometria linear.Para o teste do FEA, foi utilizado o software Rhinoceros 4.0 para obter os desenhos em 3D dos dois modelos de implantes,com o mesmo comprimento e largura, um hexágono externo HE (Titaoss® TM cortical Intraoss®, SP, Brasil) com diâmetro de 3,75 mm e comprimento de 13 mm e o segundo sendo um implante conexão interna (CM) (Titaoss® Max Cone Morse, Intraoss®, SP, Brasil). Sobre os implantes foram modelados seus abutments respectivamente, Ucla anti- rotacional com plataforma de 4.1 mm e um Pilar Cone Morse CMN com transmucoso de 0,8 mm. Ambos abutments para próteses parafusadas e foram exportados para o software de análise (ANSYS 17.0, ANSYS Inc., Houston, TX, USA) em formato STEP.Para o teste de extensometria, foram obtidos blocos de poliuretano (Poliuretano F160 ISO Axson, Cercy, França) de forma retangular com dimensões internas de 95 x 45 x 30 mm e intalados implantes Titaoss® Max Cone Morse 3,75 X 13 mm e os implantes Titaoss® TM 3,75 X 13 mm (Intraoss- SP - Brasil), e os abutments e coroas metálicas de cromo-cobalto. Formado 4 grupos: a) CM no; b) HE no, c) CM po e d) He po; em cada grupo foram instalados 4 extensômetros tangenciando cada um dos implantes, segundo mapas colorimétricos da região de maior microdeformação óssea. Na aplicação de carga, foi utilizado o dispositivo de aplicação de carga-DAC(Nishioka - Proc. 08/53071-4), com carga axial de 30 kg aplicadas por um período de 10 segundos (Mericske-Stern et al.) na fosseta central (carga axial).Resultados:1) FEA- a) Tensão de von-Mises gerada no conjunto implante/parafuso mostrou maior concentraçao de tensao no parafuso protético de ambos os grupos independente da perda óssea; b) Tensão de von-Mises gerada na região mais estressada que mostrou a possível falha na região da cabeça do parafuso de ambos os grupos independente da perda óssea; c) Tensão de von-Mises gerada no implante em secçao longitudinal foi maior concentraçao de tensao na plataforma do hexagono externo, mas, com pouca diferença no restante do corpo do implante, e d) microdeformaçao gerada no interior do bloco de poliuretano .Não foi possível notar diferenças significativas entre as diferentes conexões. Para os implantes com perda óssea é possível notar maior deformaçao ápica. 2) Na extensometria foi realizada a média da deformação gerada de cada os quatro grupos, no qual não apresentou diferenças numéricas entre os grupos. Neste estudo podemos concluir que não há diferenças significativas na microdeformação entre o grupo dos implantes CM no e HE no, com uma maior deformação CM e HE quando há presença de perda óssea(AU)


Although there is a high success rate, dental implants may lose osseintegration after implantation of prostheses on implants and the causes are peri-implantitis and occlusal loads.Different connections have emerged for better aesthetic and biomechanical performance to prevent perimplant bone loss.To analyze the deformations generated around the implants and their connections, the two methodologies used in this study and which present numerical results were the analysis of finite elements and linear extensometry.The Rhinoceros 4.0 software was used to obtain the 3D drawings of the two implant models with the same length and width, an external hexagon HE (Titaoss® TM cortical Intraoss®, SP, Brazil) with a diameter of 3.75 mm and a length of 13 mm and the second being an internal connection (CM) implant (Titaoss® Max Cone Morse, Intraoss®, SP, Brazil). The abutments were modeled on the implants, respectively, Ucla anti-rotational with 4.1 mm platform and a Morse Cone Abutment CMN with 0.8 mm transmucous. Both abutments for screwed prostheses and were exported to the analysis software (ANSYS 17.0, ANSYS Inc., Houston, TX, USA) in STEP format.For the extensometry test, rectangular polyurethane blocks (Polyurethane F160 ISO Axson, Cercy, France) with internal dimensions of 95 x 45 x 30 mm and Titaoss® Max Cone Morse 3.75 X 13 mm implants and implants were obtained Titaoss® TM 3.75 X 13 mm (Intraoss-SP - Brazil), and the abutments and metallic crowns of chromium-cobalt. Forming 4 groups: a) CM no; b) HE no; c) CM po and d) He po, each group installed 4 strain gauges tangent to each of the implants, according to colorimetric maps of the region with the greatest bone microdeformation. In the load application, the DAC load application device (Nishioka- Proc. 08 / 53071-4) was used, with an axial load of 30 kg applied for a period of 10 seconds (Mericske-Stern et al.) In the pit central (axial load).Results: 1) FEA- a) von-Mises tension generated in the implant / screw set showed a higher concentration of tension in the prosthetic screw of both groups regardless of bone loss; b) von-Mises tension generated in the most stressed region, showing possible failure in the screw head region of both groups regardless of bone loss; c) VonMises stress generated in the implant in longitudinal section was higher stress concentration in the external hexagon platform but with little difference in the rest of the implant body, and d) microdeformation generated inside the polyurethane block, it was not possible to notice significant differences between the different connections. For implants with bone loss, it is possible to notice greater apical deformation. 2) In the extensometry, the average strain generated for each of the four groups was performed, in which there were no numerical differences between the groups. In this study we can conclude that there was no difference in microdeformation between the group of CM implants and HE no, with a greater CM and HE deformation when there is bone loss(AU)


Subject(s)
Bone Resorption/diagnostic imaging , Dental Implants/trends , Alveolar Bone Loss/complications
12.
Rev. Asoc. Argent. Ortop. Traumatol ; 86(4) (Nro Esp - ACARO Asociación Argentina para el Estudio de la Cadera y Rodilla): 483-492, 2021.
Article in Spanish | LILACS, BINACIS | ID: biblio-1353949

ABSTRACT

Introducción: Las alternativas reconstructivas para defectos óseos severos en la cirugía de revisión de prótesis son las camisas metafisarias, los conos de metal trabecular y el injerto óseo impactado o estructural. El objetivo del estudio fue analizar la tasa de osteointegración de los conos de metal trabecular en pacientes con cirugía de revisión de prótesis total de rodilla. El objetivo secundario fue analizar los resultados funcionales, las tasas de complicaciones y reoperaciones. Materiales y Métodos: Cohorte retrospectiva de pacientes con conos de metal trabecular colocados en la cirugía de revisión de prótesis y un seguimiento mínimo de 2 años. Se evaluaron las causas de la revisión, cirugías previas, tipo de defecto óseo, cantidad y tipo de conos utilizados, y los diseños de las prótesis. Se realizó una evaluación clínico-radiográfica, se registraron las complicaciones y las revisiones ulteriores. Resultados: Se evaluó a 35 pacientes (49 conos de metal trabecular) en forma retrospectiva, con un seguimiento promedio de 32.1 meses. La mayoría de los defectos eran tibiales AORI 3, seguidos de los femorales tipo 3. La tasa de osteointegración de los conos fue del 94%; la de complicaciones, del 20% y la de reoperaciones, del 8,5%. El KSS objetivo promedio aumentó de 39 en el preoperatorio a 71 en el último control y el puntaje de la EAV promedio fue 8 y 2,5, respectivamente. Conclusión: La excelente tasa de osteointegración (94%) y los buenos resultados clínicos posicionan a los conos de metal trabecular como una alternativa para los defectos óseos severos. Nivel de Evidencia: IV


Introduction: Major bone defects represent a challenge during revision total knee arthroplasty (TKA) and there is still considerable debate about the best therapeutic option. The purpose of this study was to retrospectively assess the osseointegration rate of trabecular metal cones in revision TKA with severe bone defects. The secondary purpose was to evaluate the functional outcomes and complication and reoperation rates. Materials and Methods: A single-center, retrospective cohort including all consecutive cases of revision TKA using trabecular metal cones. All patients with a minimum 2-year follow-up were included in the study. Reasons for revision, number of previous surgeries, type of bone defect, and number and type of trabecular cones used were evaluated. Clinical and radiological outcomes were also analyzed as well as complications rates. Results: 35 patients (49 cones) were evaluated with a mean follow-up of 32.1 months (24-62). Most defects were localized in the tibia and were classified as AORI type 3. The rate of osseointegration of the cones was 94%; the complication rate, 20%; and the reoperation rate, 8.5%. The mean KSS increased from 39 preoperatively to 71 at the last follow-up, and the mean VAS from 8 to 2.5. Conclusion: The excellent osseointegration rate (94%), added to the good clinical outcomes, position the trabecular metal cones as an alternative to treat severe bone defects. Level of Evidence: IV


Subject(s)
Reoperation , Tantalum , Bone Resorption , Follow-Up Studies , Osseointegration , Treatment Outcome , Arthroplasty, Replacement, Knee
13.
Rev. Odontol. Araçatuba (Impr.) ; 41(3): 9-14, set./dez. 2020. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1121722

ABSTRACT

Cistos Periapicais são proliferações dos restos epiteliais de Malassez em decorrência do processo desenvolvimento ou inflamatório devido necrose pulpar. Apresenta-se no início de forma assintomática, e dependendo da sua evolução pode levar a expansão da corticais e reabsorção óssea. Ao exame de imagem se apresentam como uma área radiotransparente bem delimitada, circunscrita por halo radiopaco geralmente associado a região apical de uma ou mais unidades dentárias. O objetivo desse trabalho é relatar abordagem cirúrgica de enucleação e curetagem de um cisto periapical em região maxilar(AU)


Periapical cysts are proliferations of the epithelial remains of Malassez due to the development or inflammatory process due to pulp necrosis. It presents at the beginning asymptomatic, and depending on its evolution may lead to cortical expansion and bone resorption. Imaging studies present as a well-defined radiotransparent area, circumscribed by a radiopaque halo generally associated with the apical region of one or more dental units. The objective of this study is to report a surgical approach of enucleation and curettage of a periapical cyst in the maxillary region(AU)


Subject(s)
Radicular Cyst , Radicular Cyst/surgery , Bone Resorption , Odontogenic Cysts , Radicular Cyst/diagnosis , Dental Pulp Necrosis , Cysts
14.
Rev. Ateneo Argent. Odontol ; 63(2): 13-17, nov. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1150415

ABSTRACT

La acción terapéutica favorable que los antirresortivos (bifosfonatos BPs, denosumab DS) y drogas antiangiogénicas ocasionan en el tejido óseo en aquellos pacientes que presentan como causa etiológica cáncer o discrasias óseas incluyen hipercalcemias malignas o ­si requieren el consumo de dicha droga a baja concentración­ como ser: osteoporosis, osteopenia, enfermedad de Paget, displasia fibrosa, Osteogénesis Imperfecta. (1) La presente actualización pretende relacionar el tratamiento odontológico con prescripción crónica y drogas antirresortivas, para lo cual American Association of Oral and Maxillofacial Surgeons AAOMS: define el concepto de Osteonecrosis Maxilar Asociada a drogas Antirresortivas (MRONJ) como: «Área ósea necrótica expuesta al medio bucal con más de ocho semanas de permanencia, en presencia de tratamiento crónico con bifosfonatos en ausencia de radioterapia en cabeza y cuello¼. La AAOMS estableció los siguientes grupos de acuerdo con sus características clínicas en 4 estadios (0, 1 ,2 y 3) de acuerdo con el aspecto clínico y radiológico de la lesión osteonecrótica. Estadío 0: lesión osteonecrótica sin evidencia de hueso necrótico en pacientes bajo consumo de drogas antirresortivas. Estadío 1: lesión osteonecrótica con signos clínicos y ausencia de sintomatología clínica. Estadío 2: lesión osteonecrótica con signo y sintomatología clínica evidente. Estadío 3: lesión osteonecrótica con signo y sintomatología evidente que compromete a estructuras nobles: fracturas patológicas, anestesia del nervio dentario inferior, comunicación buco-nasal, comunicación buco-sinusal, fístulas cutáneas (2) (AU)


It is known the favourable action which antiresorptive (Bisphosphonates BPs, Denosumab: DS) and Antiangiogenic drugs produce in bone tissue. High concentrations are primarily used as an effective treatment in the management of cancer-related disorders, including hypercalcemia of malignant. Besides, low concentrations are used for other metabolic bone diseases including Osteoporosis, Osteopenia, Paget's Disease, Fibrous Dysplasia, Imperfect Osteogenesis. (1) The update relate relationship between dentistry and chronic treatment with antiresorptive drugs. According to the American Association of Oral and Maxillofacial Surgeons (AAOMS), MRONJ is defined as exposed or necrotic bone in the maxillofacial region that has persisted for more than 8 weeks in association with current or previous BPs or DS therapy and with a lack of head and neck radiotherapy. AAOMS divided the MRONJ into 4 stages (0,1, 2 and 3) according to the clinical and radiological aspect of the osteonecrotic lesion: Stage 0: osteonecrotic lesion without sign-pathognomonic evidence of osteonecrosis. Stage 1: osteonecrotic lesion with clinical signs and absence of clinical symptoms. Stage 2: osteonecrotic lesion with sign and evident clinical symptoms. Stage 3: osteonecrotic lesion with signs and evident symptoms that involve noble structures: pathological fractures, anaesthesia of the lower dental nerve, oral-nasal communication, oral-sinus communication, skin fistulas (2) (AU)


Subject(s)
Humans , Female , Aged , Bone Resorption , Diphosphonates/adverse effects , Bone Density Conservation Agents , Bisphosphonate-Associated Osteonecrosis of the Jaw , Bone Diseases , Dental Care for Chronically Ill , Angiogenesis Inhibitors , Denosumab , Mouthwashes/therapeutic use
15.
Rev. Ateneo Argent. Odontol ; 63(2): 39-54, nov. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1150748

ABSTRACT

La búsqueda por encontrar métodos para acortar la duración de los tratamientos de ortodoncia tiene un pasado reciente, un presente y un futuro. Las fuerzas ortodóncicas que se ejercen sobre la membrana periodontal producen movimientos dentarios por modificaciones histológicas y biomoleculares. El conocimiento de los procesos biológicos da lugar a implementar cambios para favorecer la aceleración de los procesos resortivos y neoformativos. El objetivo de esta publicación es hacer una breve síntesis de lo acontecido con este tema y exponer el procedimiento de las micro-osteoperforaciones (MOPs) como una opción complementaria al tratamiento de ortodoncia convencional. Aún no existe suficiente apoyo de ensayos clínicos en humanos para aseverar su éxito. Más aún, distintos autores publican conclusiones contradictorias. Es de esperar que, en breve, nuevas investigaciones contribuyan a respaldarlo o desestimarlo (AU)


The quest to find methods to shorten the duration of orthodontic treatments has a recent past, a present, and a future. Orthodontic forces exerted on the periodontal membrane produce tooth movements by histological and biomolecular modifications. Knowledge of biological processes results in changes to promote the acceleration of spring and neoformative processes. The objective of this publication is to make a brief synthesis of what happened with this topic and expose the micro-osteoperforations (MOPs) procedure as a complementary option to conventional orthodontic treatment. There is not yet enough support from human clinical trials to assert its success. Moreover, different authors publish conflicting conclusions. It is to be expected that, shortly, further investigations will help to support or dismiss it (AU)


Subject(s)
Humans , Tooth Movement Techniques/methods , Biological Phenomena , Oral Surgical Procedures , Microsurgery , Osteotomy/methods , Bone Resorption/physiopathology , Low-Level Light Therapy , RANK Ligand , Duration of Therapy
16.
Rev. bras. ortop ; 55(5): 585-590, Sept.-Oct. 2020. tab, graf
Article in English | LILACS | ID: biblio-1144216

ABSTRACT

Abstract Objective Coracoid osteolysis has been described as a possible complication after the Latarjet procedure. The aim of the present study was to investigate the incidence and risk factors associated to coracoid graft osteolysis and to correlate them with clinical results. Methods A retrospective review of 38 Latarjet procedures was conducted. Computed tomography (CT) scans were obtained from all of the patients before and at least 1 year after the surgery. Coracoid osteolysis was evaluated and correlated to preoperative factors, namely: age, smoking status, and preoperative glenoid bone loss. The patients were divided into 2 groups: A (no or minor bone resorption) and B (major or total bone resorption). The functional outcome was determined by the Rowe score. Results Coracoid graft osteolysis occurred in 22 cases (57.8%). The mean preoperative glenoid defect was 22.8% in group A, and 13.4% in group B (p= 0.0075). The mean ages of the subjects in both groups were not significantly different. Smoking did not seem to affect the main outcome either, and no correlation was found between graft osteolysis and postoperative range of motion, pain, or Rowe score. There were no cases of recurrent dislocations in our sample, although four patients presented with a positive anterior apprehension sign. Conclusion Bone resorption of the coracoid graft is present in at least 50% of the patients submitted to the Latarjet procedure, and the absence of significant preoperative glenoid bone loss showed to be the only risk factor associated with severe graft osteolysis, even though this did not influence significantly the clinical outcome.


Resumo Objetivo Osteólise do processo coracoide é descrita como uma possível complicação da cirurgia de Latarjet. O objetivo do presente estudo foi avaliar a incidência e fatores de risco associados à osteólise do enxerto do coracoide e correlacioná-los com resultados clínicos. Métodos Foi realizada uma revisão retrospectiva incluindo 38 casos submetidos ao procedimento de Latarjet. Em todos os casos, foi realizada uma tomografia computadorizada antes e pelo menos 1 ano após a cirurgia. A presença de osteólise do coracoide foi avaliada e correlacionada com os seguintes fatores de risco: idade, tabagismo, e perda óssea pré-operatória da glenóide. Os pacientes foram divididos em dois grupos: A (ausência ou menor reabsorção óssea) e B (maior reabsorção óssea ou total). A avaliação funcional foi determinada através do escore de Rowe. Resultado Osteólise do processo coracoide ocorreu em 22 casos (57,8%). O defeito ósseo médio pré-operatório da glenóide foi de 22,8% no grupo A e de 13,4% no grupo B (p= 0.0075). A média de idade dos casos em ambos os grupos não apresentou diferença estatística. Tabagismo também não esteve relacionado com diferenças no resultado. Não houve correlação entre a presença de osteólise e o arco de movimento, dor ou ao escore de Rowe. Não houve casos de reluxação; entretanto, quatro pacientes apresentaram apreensão anterior no exame físico. Conclusão A reabsorção do processo coracoide ocorreu em pelo menos 50% dos pacientes submetidos à cirurgia de Latarjet, e a ausência pré-operatória de perda óssea significativa da glenóide foi o único fator de risco associado a osteólise mais severa do enxerto, porém sem influência no resultado clínico.


Subject(s)
Humans , Male , Adult , Osteolysis , Pain , Shoulder Dislocation , Shoulder Joint , Tobacco Use Disorder , Bone and Bones , Bone Resorption , Smoking , Tomography, X-Ray Computed , Range of Motion, Articular , Coracoid Process , Joint Instability
17.
Arq. bras. med. vet. zootec. (Online) ; 72(2): 317-322, Mar./Apr. 2020. ilus
Article in English | LILACS, VETINDEX | ID: biblio-1128169

ABSTRACT

A 10-year-old male mixed-breed dog was admitted for recurrent signs of urinary tract infection (UTI). Urinary bladder ultrasonography revealed decreased thickness of its wall with floating hyperopic particles within its lumen. Ultrasonography revealed a structure invading the dorsal wall of the penile urethral lumen, located in a segment distal to the bladder. Radiographies showed bone resorption with proliferation at the caudal aspect of the penile bone, stricture of the final aspect of the penile urethra, and no radiopaque images compatible with a urethrolith. Computed tomography showed bone proliferation causing stricture of the urethral lumen at two different sites. Presumptive diagnosis of penile neoplasia was considered more likely and the dog underwent penectomy along with orchiectomy and scrotal urethrostomy. Enterobacter spp. was cultured from the urine sample and antibiotic sensitivity tests revealed that the bacterium was susceptible to amikacin, imipenem, and meropenem. Histopathology revealed severe suppurative urethritis, bone resorption, and hyperostosis, suggestive of osteomyelitis of the penile bone. Neoplastic cells were not observed at any part of the examined tissue. The findings in the present case suggest that osteomyelitis of the penile bone should be included in differential diagnosis for partial and complete urethral obstruction in dogs with recurrent UTI.(AU)


Um cão mestiço, com 10 anos, foi admitido por sinais recorrentes de infecção do trato urinário (ITU). A ultrassonografia da bexiga urinária revelou diminuição da espessura de sua parede com partículas flutuantes dentro de seu lúmen. A ultrassonografia demonstrou estrutura invadindo a parede dorsal do lúmen da uretra peniana, localizada em segmento distal à bexiga. Radiografias evidenciaram reabsorção óssea com proliferação no aspecto caudal do osso peniano, estenose do aspecto final da uretra peniana e ausência de imagens radiopacas compatíveis com uretrólito. Pela tomografia computadorizada, observou-se proliferação óssea causando estreitamento da luz uretral em dois locais diferentes. Diagnóstico presuntivo de neoplasia peniana foi considerado mais provável e o cão foi submetido à penectomia, juntamente com orquiectomia e uretrostomia escrotal. Enterobacter spp. foi cultivada da amostra de urina e testes de sensibilidade revelaram susceptibilidade ao amicacina, imipenem e ao meropenem. A histopatologia revelou uretrite supurativa grave, reabsorção óssea e hiperostose compatível com osteomielite do osso peniano. Células neoplásicas não foram observadas em nenhuma parte do tecido examinado. Os achados do presente caso sugerem que a osteomielite do osso peniano deve ser incluída no diagnóstico diferencial de obstrução uretral parcial e completa em cães com ITU recorrente.(AU)


Subject(s)
Animals , Male , Dogs , Osteomyelitis/veterinary , Penis , Urethritis/veterinary , Urinary Tract Infections/veterinary , Enterobacter , Bone and Bones , Bone Resorption , Tomography, X-Ray Computed
18.
Braz. dent. j ; 31(2): 122-126, Mar.-Apr. 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1132280

ABSTRACT

Abstract Although periodontitis is one of the commonest infectious inflammatory diseases in humans, the mechanisms involved with its immunopathology remain ill understood. Numerous molecules may induce inflammation and lead to bone resorption, secondary to activation of monocytes into osteoclasts. TACE (TNF-α converting enzyme) and DC-STAMP (dendritic cell-specific transmembrane protein) appear to play a role on bone resorption since TACE induces the release of sRANKL (soluble receptor activator of nuclear factor kappa-β ligand) whereas DC-STAMP is a key factor in osteoclast induction. The present study evaluated the levels of TACE and DC-STAMP in patients with and without periodontitis. Twenty individuals were selected: 10 periodontally healthy participants undergoing gingivectomy for esthetic reasons and 10 diagnosed with periodontitis. Protein levels of such molecules in gingival tissue were established using Western blotting. Protein levels of both TACE and DC-STAMP were higher in the periodontitis group than in the control group (p<0.05; Student t-test). In conclusion, TACE and DC-STAMP protein levels are elevated in patients with periodontitis, favoring progression of bone resorption.


Resumo Apesar de a periodontite ser uma das doenças infecto inflamatórias humanas mais comuns, os mecanismos que conduzem à imunopatologia não estão bem definidos. Inúmeras moléculas induzem atividade inflamatória que levam à perda óssea. Para que haja a reabsorção óssea, células monocíticas são ativadas e se transformam em osteoclastos. As moléculas TACE (Enzima conversora de TNF-α) e DC-STAMP (Proteína transmembrana específica de célula dendrítica) parecem atuar no processo de reabsorção óssea uma vez que a TACE induz a liberação de sRANKL (ativador do receptor do fator nuclear kappa-β ligante solúvel), enquanto a DC-STAMP é um fator chave na indução dos osteoclastos. Diante disso, o presente estudo avaliou a expressão gênica das moléculas TACE e DC-STAMP em pacientes com e sem periodontite uma vez que o papel destas moléculas no curso do desenvolvimento da periodontite ainda é pouco explorado. Foram selecionados 20 indivíduos, sendo 10 com saúde periodontal e com indicação para remoção de tecido gengival por motivos estéticos e 10 pacientes com periodontite. As análises da expressão das moléculas no tecido gengival foram realizadas por meio de western blotting. Os níveis proteicos tanto de TACE quanto de DC-STAMP, foram maiores nos tecidos do grupo com periodontite em comparação aos do grupo controle (p<0.05; Student' t-test). Portanto, os dados demonstram que a expressão protéica das moléculas TACE e DC-STAMP estão elevados em pacientes com periodontite, favorecendo a progressão da reabsorção óssea nesta patologia.


Subject(s)
Humans , Periodontitis , Bone Resorption , Adaptor Proteins, Signal Transducing/metabolism , ADAM17 Protein/metabolism , Membrane Proteins/metabolism , Osteoclasts , Cell Differentiation
19.
Int. j. morphol ; 38(1): 129-134, Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1056410

ABSTRACT

Menopause complications such as cardiovascular and bone diseases represent a major public health concern. We sought to determine whether a high-fat diet (HFD) can augment ovariectomy-induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomarkers and dyslipidemia. Rats were either ovariectomized and fed a standard laboratory chow (model group) or were ovariectomized and fed with a HFD for 15 weeks before being sacrificed. Ovariectomy significantly (p<0.05) increased body weight, dyslipidemia, insulin resistance, pro-inflammatory cytokines tumor necrosis factor-a (TNF-α) and interleukin-6 (IL-6), and biomarker of bone resorption, nuclear factor-kB (NF-kB), which were augmented by feeding animals with a HFD. This was confirmed through immunohistochemical study, where ovariectomy induced expression of p65/NF-kB protein in tibia bone sections of the model group, which were augmented by HFD. HFD augments ovariectomy-induced bone resorption through increased inflammatory biomarkers and NF-kB in rats.


Las complicaciones de la menopausia, como las enfermedades cardiovasculares y óseas, representan un importante problema de salud pública. Intentamos determinar si una dieta alta en grasas (HFD) puede aumentar la resorción ósea inducida por ovariectomía en un modelo de menopausia en ratas, a través de la regulación positiva de los biomarcadores inflamatorios y la dislipidemia. Las ratas fueron ovariectomizadas y alimentadas con una comida estándar de laboratorio (grupo modelo) o fueron ovariectomizadas y alimentadas con un HFD durante 15 semanas antes de ser sacrificadas. La ovariectomía aumentó significativamente (p <0,05) el peso corporal, dislipidemia, resistencia a la insulina, citocinas proinflamatorias, factor de necrosis tumoral a (TNF-α) e interleucina-6 (IL-6), y el biomarcador de resorción ósea, factor nuclear-kB (NF-kB), que se aumentaron alimentando animales con un HFD. Esto se confirmó a través del estudio inmunohistoquímico, donde la ovariectomía indujo la expresión de la proteína p65 / NF-kB en secciones de hueso de tibia del grupo modelo, que fueron aumentadas por HFD. HFD aumenta la resorción ósea inducida por ovariectomía a través del aumento de biomarcadores inflamatorios y NF-kB en ratas.


Subject(s)
Animals , Female , Rats , Bone Resorption/pathology , Diet, High-Fat/adverse effects , Triglycerides/analysis , Bone Resorption/etiology , Insulin Resistance , Menopause , Ovariectomy/adverse effects , Rats, Wistar , Disease Models, Animal , Dyslipidemias/complications
20.
Article in English | WPRIM | ID: wpr-811258

ABSTRACT

PURPOSE: The purpose of this study was to utilize cone-beam computed tomography (CBCT) image analysis to obtain anatomical information related to the morphology of the incisive foramen to provide useful data regarding implant placement and clinical procedures such as anesthesia.METHODS: The study included 167 patients who underwent CBCT scans over 20 years. Three components were measured: 1) the anteroposterior and mediolateral diameter of the incisive foramen, 2) the horizontal bone thickness anterior to the incisive foramen, and 3) the vertical bone height coronal to the incisive foramen. All measurements were expressed as mean±standard deviation and were analyzed by a single examiner.RESULTS: The anteroposterior diameter of the incisive foramen was wider than the mediolateral diameter (P<0.001). The diameter of the incisive foramen in patients in whom the central incisors were present was smaller than that in those in whom at least one central incisor was absent, but no statistically significant difference between the groups was observed. The horizontal bone thickness in the patients with central incisors was statistically significantly larger than that in the patients without at least one central incisor (P<0.001). The same pattern was observed with regard to vertical height, but that difference was not statistically significant.CONCLUSIONS: The buccal bone thickness anterior to the incisive foramen was significantly decreased after central incisor loss. It is necessary to identify the morphology of the bone and the location of the incisive foramen via CBCT to avoid invasion of the incisive foramen and nasopalatine canal.


Subject(s)
Anesthesia , Bone Resorption , Cone-Beam Computed Tomography , Dental Implants , Humans , Incisor , Maxilla
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