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Introducción: Pos-pandemia COVID-19 los centros de salud vieron incrementados el número de consultas en salud mental (SM). Objetivos: -Evidenciar el aumento de la demanda en SM pos-pandemia. Pre y pos-pandemia: -Comparar las características de demanda en SM -Relevar las demandas del área judicial (DAJ) -Evaluar la dispensa de psicofármacos (PF) Material y Métodos: Trabajo descriptivo, retrospectivo, poblacional. Pacientes atendidos en SM del Área Programática del Hospital Penna. Se obtuvieron consultas de psicología (PSI) psiquiatría y psicopedagogía, motivo de consulta, edad, sexo, dispensa de psicofármacos (PF) desde el 1/01 al 31/12/2019 y mismo período 2022. Los datos se analizaron en frecuencia, porcentaje. Resultados: Las consultas pos-pandemia aumentaron un 8%, los pacientes atendidos aumentaron 37.91%. Las consultas PSI pediatría/adolescencia descendieron 6.5% en 2022 predominando niños en 2019 y niñas en 2022. En adultos aumentó 20.10%, predominando mujeres ambos períodos. Si bien consumo, violencia y angustia fueron nombrados en ambos periodos, pobreza apareció en 2022. Las DAJ aumentaron más del 1000%. La dispensa PF aumentó más del 100%. Conclusiones: En pos-pandemia aumentaron las consultas de PSI y los DAJ. El aumento en dispensa PF evidencia el deterioro y la complejidad de la SM pos-pandemia. Estos datos, plantea la necesidad de incorporar nuevos profesionales

Introduction: Post- COVID-19 pandemic, health care centers increased the number of mental health (MH) consultations. Objectives: - Evidence the increase in demand for SM post-pandemic. Pre and post-pandemic: -Compare the characteristics of demand in SM -Review the demands of the judicial area (DAJ) -Evaluate the dispensation of psychotropic drugs (PF) Material and Methods: Descriptive, retrospective, population-based study. Patients treated in SM at the Programmatic Area of the Penna Hospital. Consultations from psychology (PSI), psychiatry and psychopedagogy, reason for consultation, age, sex, dispensation of psychotropic drugs (PF) were obtained from 01/01 to 12/31/2019 and the same period 2022. The data was analized in frequency and percentage. Results: Post-pandemic consultations increased by 8%, patients treated increased by 37.91%. Pediatric/adolescent PSI consultations decreased 6.5% in 2022, with boys predominating in 2019 and girls in 2022. In adults it increased 20.10%, with women predominating in both periods. Although consumption, violence and distress were mentioned in both periods, poverty appeared in 2022. The DAJ increased more than 1000%. The PF dispensation increased more than 100%. Conclusions: In the post-pandemic, PSI and DAJ consultations increased. The increase in FP dispensation shows the deterioration and complexity of post-pandemic SM. These data raise the need to incorporate new professionals

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OBJECTIVE: To describe the use of telemedicine by health professionals for diagnosis or treatment of patients during the Covid-19 pandemic. METHOD: This is a systematic literature review of observational studies. Five databases were used. The assessment of the studies methodological quality occurred individually among the revisors and the Joanna Briggs Institute (JBI) tool was used. RESULTS: The reviewers selected 22 articles from 6,180 works. The services provided through telemedicine were consultation/screening, consultation/follow-up or monitoring, test reports, medication prescriptions and case discussions. The technological resources used were platforms using video and telephone (audio and video). The use of telemedicine made it possible to reduce their exposure to Covid-19, reduce social panic and anxiety, quickly medical specialties access and the possibility of access to diagnosis and treatment of patients with chronic and acute diseases. CONCLUSION: Telemedicine can be an important tool in healthcare, keeping patients and healthcare professionals safe during the Covid-19 pandemic.

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Abstract The concept of pharmakon encapsulates the paradoxical ambivalence of any therapeutic intervention's harmful as well as beneficial effects; within the context of immunological practices related to covid-19, this ambivalence has been successfully exploited by anti-vaccination movements and is also evident in widespread vaccine hesitancy in wealthy countries where vaccines for this virus are widely available. Here we engage with the theoretical apparatus of the pharmakon to examine how care, harm, risk, and prevention are enacted in covid-19 prevention measures and mobilize the transdisciplinary methodologies of science and technology studies to investigate how anticipatory imaginaries drive cutting-edge research on covid-19 vaccines and the clinical and social practices they have elicited.

Resumo O conceito de pharmakon abrange a ambivalência paradoxal dos efeitos nocivos e benéficos de qualquer intervenção terapêutica. No contexto das práticas imunológicas relacionadas à covid-19, essa ambivalência tem sido explorada com sucesso pelo movimento antivacina e também é evidente na hesitação vacinal generalizada em países ricos, onde vacinas contra essa doença estão amplamente disponíveis. Aqui, examinamos o aparato teórico do pharmakon para verificar como o cuidado, o dano, o risco e a prevenção são implementados nas medidas de prevenção da covid-19 e mobilizamos metodologias transdisciplinares dos estudos de ciência e tecnologia para investigar como imaginários antecipatórios impulsionam a pesquisa de ponta sobre as vacinas contra a covid-19 e as práticas clínicas e sociais que elas suscitaram.

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Objetivo: verificar asociaciones entre variables sociodemográficas y factores que facilitan y dificultan la transición de la atención psicológica presencial a la modalidad remota en el primer año de la pandemia de COVID-19. Método: se trata de un estudio analítico, cuantitativo y de corte transversal. Después de la aprobación del Comité de Ética en Investigación, la recolección de datos se realizó mediante la aplicación de un formulario en línea que consta de 55 preguntas. Los datos fueron analizados utilizando técnicas de estadística descriptiva e inferencial. Resultados: la muestra de conveniencia estuvo compuesta por 385 psicólogos brasileños, en su mayoría mujeres (67,01%), jóvenes profesionales con hasta cinco años de actuación después de la graduación (44,16%) y predominio de actividades en la clínica privada. Se encontró que el tiempo de formación entre cinco y 10 años se asoció con una mayor percepción de dificultades y que la experiencia previa con la atención a distancia facilitó la adaptación en la transición de una modalidad a otra. Conclusión: considerando que la teleasistencia puede ser una poderosa herramienta en el escenario de la salud, se sugiere que los temas de la teleasistencia sean incluidos en la agenda de investigación y los contenidos programáticos en los currículos de los cursos de formación en salud.

Objective: to verify associations between sociodemographic variables and factors that facilitate and hinder the transition from face-to-face psychological care to remote mode in the first year of the COVID-19 pandemic. Method: this is an analytical, quantitative, cross-sectional study. After approval by the Research Ethics Committee, data collection was performed by applying an online form consisting of 55 questions. Data were analyzed using descriptive and inferential statistics techniques. Results: the intentional sampling consisted of a total of 385 Brazilian psychologists, mostly women (67.01%), young professionals with up to five years of graduation (44.16%) most of activities in the private clinic. It was found that training time between five and 10 years was associated with a greater perception of difficulties and that previous experience with remote care facilitated adaptation in the transition from one modality to another. Conclusion: considering that call center can be a powerful tool in the health scenario, it is suggested the inclusion of remote care issues in the research agenda and syllabus in the curricula of health training courses.

Objetivo: verificar associações entre variáveis sociodemográficas e fatores facilitadores e dificultadores da transição do atendimento psicológico presencial para a modalidade remota no primeiro ano da pandemia de COVID-19. Método: trata-se de um estudo analítico, quantitativo, de corte transversal. Após aprovação do Comitê de Ética em Pesquisa, a coleta foi realizada mediante aplicação de um formulário online composto por 55 questões. Os dados foram analisados por meio de técnicas de estatística descritiva e inferencial. Resultados: a amostra de conveniência foi composta por 385 psicólogos brasileiros, majoritariamente mulheres (67,01%), jovens profissionais com até cinco anos de ofício após a graduação (44,16%) e com predomínio de atividades na clínica privada. Constatou-se que o tempo de formação entre cinco e 10 anos foi associado com uma maior percepção de dificuldades e que a experiência prévia com atendimento remoto foi facilitadora da adaptação na transição de uma modalidade à outra. Conclusão: considerando que o teleatendimento pode ser uma ferramenta potente no cenário da saúde, sugere-se a inclusão das questões do atendimento remoto na agenda de pesquisa e conteúdos programáticos das grades curriculares dos cursos de formação em saúde.

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El propósito del estudio fue cuantificar el tamaño de efecto (TE) del ejercicio aeróbico sobre la capacidad cardiorrespiratoria en sobrevivientes de la enfermedad COVID-19, producida por el virus SARS-CoV 2. Se revisaron dos bases de datos (EBSCO host y PubMed) entre los meses de agosto a noviembre del año 2021. Se encontraron 142 656 posibles artículos y, luego de varios filtros, se incluyeron 9 estudios que cumplían los requisitos de inclusión. Se usó el modelo de efectos aleatorios. Se obtuvieron 12 TE en un primer meta-análisis que tuvo sesgo (según prueba de Egger). Tras identificar y eliminar grupos con TE extremo, se obtuvo un modelo corregido y sin sesgo con 7 estudios y 9 TE, donde se encontró que el ejercicio aeróbico tiene un efecto significativo, positivo y de magnitud grande sobre la condición cardiorrespiratoria en sobrevivientes a la enfermedad de COVID-19 (TE = 0.849; IC95%: 0.715 - 0.982; . = 7.13; . = 0.522; I. = 0.87%; Egger . = 0.205). Las intervenciones con ejercicio aeróbico favorecen la mejora de la capacidad cardiorrespiratoria en pacientes sobrevivientes de COVID-19. Dos estudios aplicaron solo ejercicio aeróbico, mientras que los otros siete combinaban aeróbico con ejercicio de fuerza y otras modalidades. En todos los casos se tuvo TE significativo. Finalmente, estos resultados fueron relativamente homogéneos, sin evidenciar la influencia de posibles variables moderadoras.

The purpose of this study was to quantify the effect size (TE) of aerobic exercise on cardiorespiratory capacity in survivors of the COVID-19 disease caused by the SARS-CoV 2 virus. Two data bases (EBNSCO host and PubMed) were reviewed over the months of August through November, 2021. A total 142 656 potential articles were reviewed and, after applying several filters, 9 studies that met the requirements for inclusion were included. The random effect model was used. A first meta-analysis that was biased (according to Egger test) obtained 12 TE. After identifying and eliminating groups with an extreme TE, a corrected, unbiased model was obtained with 7 studies and 9 TE was obtained, where it was found that aerobic exercise has a significant, positive and large-magnitude effect on the cardiorespiratory condition on survivors of the COVID-19 disease (TE = 0.849; IC95%: 0.715 - 0.9 82; Q = 7.13; p = 0.522; I2 = 0.87%; Egger p = 0.205). Interventions with aerobic exercise foster an improvement in cardiorespiratory capacity in patients who survived COVID-19. Two studies applied aerobic exercise only, whereas the other seven combined aerobic exercise with strength exercise and other modes. In all cases, a significant TE was obtained. Finally, these results were relatively homogeneous, with no evidence for the influence of possible moderating variables.

O objetivo do estudo foi quantificar o tamanho do efeito (TDE) do exercício aeróbico na aptidão cardiorrespiratória em sobreviventes da doença COVID-19, produzida pelo vírus SARS-CoV 2. Foram revisadas duas bases de dados (EBSCO host e PubMed) entre agosto e novembro de 2021. Foi encontrado um total de 142.656 artigos em potencial e, após vários filtros, foram incluídos 9 estudos que atendiam aos requisitos de inclusão. Foi usado o modelo de efeitos aleatórios. Foram obtidos 12 TDE em uma primeira metanálise que era tendenciosa (de acordo com o teste de Egger). Depois de identificar e eliminar os grupos com TDE extremo, foi obtido um modelo corrigido e imparcial com 7 estudos e 9 TDE, no qual se constatou que o exercício aeróbico tem um efeito significativo, positivo e de grande magnitude sobre a aptidão cardiorrespiratória em sobreviventes da doença COVID-19 (TDE = 0,849; IC95%: 0,715 - 0,982; . = 7,13; . = 0,522; I. = 0,87%; Egger . = 0,205). As intervenções com exercícios aeróbicos melhoram o condicionamento cardiorrespiratório em sobreviventes da COVID-19. Dois estudos usaram apenas exercícios aeróbicos, enquanto os outros sete combinaram exercícios aeróbicos com exercícios de força e outras modalidades. Em todos os casos, houve um TDE significativo. Por fim, esses resultados foram relativamente homogêneos, sem evidências da influência de possíveis variáveis moderadoras.

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INTRODUCCIÓN: La pandemia por COVID-19 es un problema de salud mundial. Habitualmente cursa con sintomatología leve y 5% de los afectados evoluciona a cuadros graves que requieren de cuidados intensivos. OBJETIVO: Determinar el perfil clínico, la mortalidad y factores asociados a la misma en pacientes con COVID-19 ingresados al Departamento de Cuidados Intensivos de Adultos, del Hospital de Clínicas de la Facultad de Ciencias Médicas, Universidad Nacional de Asunción, Paraguay, entre agosto de 2020 a agosto de 2021. PACIENTES Y MÉTODO: Se realizó un estudio observacional analítico de corte transverso. Los datos se obtuvieron a partir de las historias clínicas de los pacientes. RESULTADOS: Se incluyeron 214 pacientes críticos entre 21 y 85 años de edad (mediana 54 años), 57,9% del sexo masculino, 85% provenientes del Departamento Central y Asunción. La mortalidad global fue de 38,3%. Se asociaron significativamente con la mortalidad una edad ≥ 60 años, las comorbilidades (diabetes mellitus, cardiopatía, enfermedad renal crónica), los índices de gravedad (APACHE II, SOFA, inicial), procalcitonina elevada, utilización de vasopresor, asistencia respiratoria mecánica y utilización del decúbito prono; así como la presencia de SDRA y el requerimiento de depuración extrarenal. En el análisis multivariado (por regresión logística) los factores de riesgo de mortalidad independientes fueron: la edad mayor de 60 años, la utilización de noradrenalina y depuración extra-renal durante la hospitalización. CONCLUSIÓN: Nuestra mortalidad es similar a la reportada internacionalmente. Los factores de riesgo de mortalidad identificados muestran una población con mayores posibilidades de un desenlace desfavorable.

BACKGROUND: The COVID-19 pandemic is a world health issue. Generally, it is with mild and around 5% evolves to a severe disease that requires intensive care. AIM: To determine the clinical profile, mortality and associated factors in COVID-19 patients admitted at the Adult Intensive Care Department at the Hospital de Clinicas, between August 2020 and August 2021. METHODS: Cross-section observational analytic study. Data was obtained from clinical charts. RESULTS: 214 patients were included, with an average age of 54 years, 57.9% male. Overall mortality was 38.3%. Factors associated significantly with mortality were: ≥60 years of age, comorbidity (diabetes mellitus, heart disease, chronic renal disease), severity index (APACHE II, initial SOFA), high procalcitonin, use of vasopressor, mechanical respiratory assistance and prone decubitus; as well as the presence of acute respiratory distress syndrome and hemodialysis. Multi varied analysis identified as mortality risk factors: ≥60 years of age, noradrenaline use and hemodialysis. CONCLUSION: Mortality rate is similar to that reported worldwide. Mortality risk factors identified show a population with higher possibilities for unfavorable outcome.

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INTRODUCCIÓN: COVID-19 cobró millones de vidas especialmente en la era pre-vacunas. Estudios preliminares mostraban eficacia promisoria del plasma de personas convalecientes anti SARS-CoV-2 (PPC). Objetivo: evaluar la eficacia del PPC en hospitalizados por COVID-19 de moderada gravedad. MATERIAL Y MÉTODOS: Estudio retrospectivo, bicéntrico, en adultos hospitalizados por COVID-19 moderado (no crítico) que requirieron oxigenoterapia. Al plasma donado por sobrevivientes de cuadros leves (600 cc) se les realizó búsqueda de IgG anti SARS-CoV-2. Se evaluó su impacto en mortalidad, estadía hospitalaria (días) y necesidad de ventilación mecánica (VMI). RESULTADOS: De los 119 pacientes incluidos, 58% eran hombres (edad mediana 60 años), 88% poseía comorbilidad y 43% tenía "CALL score" de alto riesgo. 43 pacientes (36%) recibieron PPC, sólo 15 (12,6%) precozmente (< 7 días). 22 pacientes debieron trasladarse a unidad intensiva, 18 recibieron VMI y 15 fallecieron (12,6%). El uso de PPC no se asoció a cambios en la mortalidad (p = 0,16), necesidad de VMI (p = 0,79) ni en la estadía hospitalaria (p = 0,24). Su administración en forma precoz (< 7 días de síntomas) tampoco demostró asociación significativa. La presencia de cardiopatía y el requerir posteriormente VMI fueron factores independientes asociados a mortalidad. CONCLUSIONES: El uso de PPC en pacientes hospitalizados por COVID-19 de moderada gravedad no se asoció a menor mortalidad, estadía hospitalaria ni necesidad de VMI.

INTRODUCTION: COVID-19 claimed millions of lives, mainly in the pre-vaccine era. Preliminary studies showed promising efficacy of convalescent plasma against SARS-CoV-2 (CP). Objective: To evaluate the efficacy of CP in patients hospitalized for COVID-19 with moderate severity. METHODS: Retrospective, bicentric study including adults hospitalized for moderate (non-critical) COVID-19 who required oxygen therapy. CP donated by survivors of mild cases (600 cc) were searched for IgG anti-SARS-CoV-2. Its impact on mortality, hospital stay (days), and need for mechanical ventilation (IMV) was evaluated. RESULTS: Of the 119 patients included, 58% were men (median age 60 years), 88% had comorbidity, and 43% had a high-risk CALL score. Forty-three patients (36%) received CP, only 15 (12.6%) early (< 7 days). Twenty-two patients had to be transferred to the intensive care unit; 18 received IMV, and 15 died (12.6%). The use of CP was not associated with changes in mortality (p = 0.16), need for IMV (p = 0.79), or hospital stay (p = 0.24). Its early administration (< 7 days of symptoms) did not show a significant association either. The presence of heart disease and subsequently requiring IMV were independent factors of mortality. CONCLUSIONS: The use of CP in patients hospitalized for moderately severe COVID-19 was not associated with lower mortality, hospital stay, or the need for IMV.

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INTRODUCTION: The poor health of prisoners in penitentiaries demonstrates a very favorable condition for the spread of the virus. OBJECTIVEbjective: To revise in the scientific literature the actions carried out by health professionals in prison units to face COVID-19. METHOD: Scoping review, guided by the recommendations of the Joanna Briggs Institute and structured from the acronym Population, Concept, and Context. The searches were carried out in 11 databases, with the inclusion criteria being studies in English, Portuguese, and Spanish; publications in 2019/2020 and available in full. For the selection of studies, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews flowchart was used. A total of 1,624 studies were found, of which 13 were eligible for the review. RESULTS: From the analysis of the studies, two categories emerged: the first, diagnosis/control, which presented as proposed strategies isolation, screening, improvement of basic sanitation, education, social distancing, use of personal protective equipment, reinforcement of ventilation measures and the use of remote connection; and, the second, treatment that encompassed screening, support, and medicalization of the relevant symptoms of the pathology linked to emotional assistance. CONCLUSIONonclusion: the analyses carried out indicate the need to develop a standard operating procedure that systematizes assistance, including prevention, diagnosis/control, and treatment of SARS-CoV-2 within the penitentiary system, briefly presenting priority actions to be carried out, emergencies needed and the flow in the services of the care network of the health systems.

INTRODUÇÃO: A precariedade da saúde dos presos nas penitenciárias demonstra uma condição muito propícia para a propagação de vírus. OBJETIVO: Mapear na literatura científica, as ações realizadas por profissionais de saúde em unidades prisionais, para enfrentamento da covid-19. MÉTODO: Scoping review, guiada pelas recomendações do Joanna Briggs Institute e estruturada a partir do acrônimo População, Conceito e Contexto. As buscas foram realizadas em 11 bases de dados, tendo como critério de inclusão estudos nos idiomas inglês, português e espanhol; publicações 2019/2020 e disponíveis na íntegra. Para seleção dos estudos foi utilizado o diagrama de fluxo Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. Foram encontrados 1624 estudos, destes, 13 foram elegíves para a revisão. RESULTADOS: A partir da análise dos estudos emergiram duas categorias: a primeira, diagnóstico/controle que apresentou como estratégias propostas o isolamento, triagem, melhoria do saneamento básico, educação, distanciamento social, utilização de equipamentos de proteção individual, reforço das medidas de ventilação e o uso da conexão remota; e, a segunda, tratamento que englobou o rastreio, suporte e medicalização dos sintomas pertinentes da patologia atrelados a uma assistência emocional. CONCLUSÃO: as análises realizadas sinalizam a necessidade de elaboração de procedimento operacional padrão que sistematize a assistência, incluindo ações de prevenção, diagnóstico/controle e tratamento do SARS-CoV-2 dentro do sistema penitenciário, apresentando sumariamente ações prioritárias a serem realizadas, as urgências necessárias e o fluxo nos serviços da rede de atenção dos sistemas de saúde.

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The corona virus disease 2019(COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has created an urgent need of scientific and effective biomarkers for the purpose of prevention and control. Currently, commonly employed viral nucleic acids, antibodies, and rapid antigen test detection technologies all exhibit a range of limitations, including restricted applicability, inadequate sensitivity and specificity. Plasma SARS-CoV-2 quantitative antigen, as an emerging biomarker, has garnered significant attention due to its potential clinical value in the diagnosis and management of COVID-19. This article comprehensively analyzes the principles and clinical applications of quantitative detection technology for plasma SARS-CoV-2 antigen. Additionally, it explores the challenges encountered in this field and provides insights into future prospects.

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The corona virus disease 2019(COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has created an urgent need of scientific and effective biomarkers for the purpose of prevention and control. Currently, commonly employed viral nucleic acids, antibodies, and rapid antigen test detection technologies all exhibit a range of limitations, including restricted applicability, inadequate sensitivity and specificity. Plasma SARS-CoV-2 quantitative antigen, as an emerging biomarker, has garnered significant attention due to its potential clinical value in the diagnosis and management of COVID-19. This article comprehensively analyzes the principles and clinical applications of quantitative detection technology for plasma SARS-CoV-2 antigen. Additionally, it explores the challenges encountered in this field and provides insights into future prospects.

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OBJECTIVES@#To investigate the clinical characteristics of neonates infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).@*METHODS@#A cross-sectional survey was conducted on 542 hospitalized neonates with confirmed coronavirus disease 2019 (COVID-19) in 27 hospitals in Shenzhen from December 7, 2022, to January 12, 2023 (during the Omicron variant epidemic period). The neonates were divided into two groups: asymptomatic infection and symptomatic infection. The clinical characteristics, results of laboratory examination, chest X-ray findings, and outcome were compared between the two groups.@*RESULTS@#Among the 542 neonates, there were 285 males and 257 females. Among them, 515 (95.0%) were full-term infants, and 27 (5.0%) were preterm infants. The asymptomatic infection group had 60 cases, and the symptomatic infection group had 482 cases. Among them, 336 cases (69.7%) were mild, 125 cases (25.9%) were moderate, 15 cases (3.1%) were severe, and 6 cases (1.2%) were critical. Fever was the most common symptom (434 cases, 90.0%), followed by cough and/or spitting (183 cases, 38.0%), nasal congestion and/or runny nose (131 cases, 27.2%), shortness of breath (36 cases, 7.5%), and feeding intolerance (30 cases, 6.2%). Among the 325 cases who underwent chest X-ray examination, 136 cases (41.8%) had patchy or consolidative shadows in the lungs, 2 cases (0.6%) had pneumothorax, 2 cases (0.6%) had decreased lung transparency, and 185 cases (57.0%) showed no abnormality. Among the 396 cases (73.1%) who received treatment, 341 cases (86.1%) received symptomatic treatment, 137 cases (34.6%) received antibiotic treatment, 4 cases (1.0%) received immunoglobulin treatment, and 23 cases (5.8%) received respiratory support treatment. All 542 neonates were discharged from the hospital after their clinical symptoms were relieved, and the median hospital stay was 5 days. The white blood cell count, neutrophil count, hemoglobin, and procalcitonin were lower in the symptomatic infection group than those in the asymptomatic infection group (P<0.05), while the platelet count and blood glucose levels were higher in the symptomatic infection group than those in the asymptomatic infection group (P<0.05). The proportions of neonates with decreased neutrophil count, increased platelet count, and decreased hemoglobin concentration were higher in the symptomatic infection group than those in the asymptomatic group (P<0.05).@*CONCLUSIONS@#Most neonates with COVID-19 caused by the Omicron variant of SARS-CoV-2 are mild, with fever as the predominant symptom. Symptomatic neonates with COVID-19 are often accompanied by decreased neutrophil count, increased platelet count, and decreased hemoglobin level. Symptomatic treatment is the main treatment, and the prognosis is good.

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In October 2021, an international collaborative study on the use of electroacupuncture (EA) to treat inflammation was published in the journal Nature by Dr. Qiufu Ma's team. Based on the results of EA on inflammation in the mouse model of lipopolysaccharide inflammatory storm, the study showed that the distal effect of acupuncture can be achieved by "driving the vagus-adrenal axis (through the adrenal medulla, by releasing catecholamines)." PROKR2Cre-marked sensory neurons, which innervate the deep hindlimb fascia but not the abdominal fascia, are crucial for driving this axis. The study suggests the existence of specificity distribution of acupoints, that different EA stimulation intensities or different needle penetration depths have different therapeutic effects, that photosensitive stimulation may be a substitute for needle acupuncture, and that massage, stretching and body movements may also activate PROKR2Cre-markable dorsal root ganglion sensory neurons and elicit anti-inflammatory effects. However, results of some other studies are contrary to the conclusions of Ma's team. For examples: low-intensity EA at GB30 point significantly reduced the inflammation in the rat model of persistent inflammation, which is more relevant to the real daily acupuncture practice, and this effect was partly related to the adrenal cortex and associated with the stimulation of corticosterone and adrenocorticotropic hormone; manual acupuncture (similar to the low-intensity EA) at KI3, Zhichuan point (an extra point), etc. was effective in a severe COVID-19 patient with sepsis; stimulating ST25 with low-intensity EA or manual acupuncture was effective against gastrointestinal inflammations; the above mentioned points are not in an area enriched with PROKR2Cre-marked sensory nerve endings. Evidence shows that the mechanism of EA against inflammation includes modulating multi-systems, multi-levels and multi-targets, which does not limit to "driving the vagus-adrenal axis." Please cite this article as: Fan AY. Anti-inflammatory mechanism of electroacupuncture involves the modulation of multiple systems, levels and targets and is not limited to "driving the vagus-adrenal axis." J Integr Med. 2023; 21(4):320-323.

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The epidemic of corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus 2 and its variants of concern (VOCs) has been ongoing for over 3 years. Antibody therapies encompassing convalescent plasma, hyperimmunoglobulin, and neutralizing monoclonal antibodies (mAbs) applied in passive immunotherapy have yielded positive outcomes and played a crucial role in the early COVID-19 treatment. In this review, the development path, action mechanism, clinical research results, challenges, and safety profile associated with the use of COVID-19 convalescent plasma, hyperimmunoglobulin, and mAbs were summarized. In addition, the prospects of applying antibody therapy against VOCs was assessed, offering insights into the coping strategies for facing new infectious disease outbreaks.

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An epidemic outbreak of the corona virus disease 2019(COVID-19) Omicron variant occurred in most regions of China. Children are susceptible to COVID-19 and the vast majority of them suffer from upper respiratory tract infection. Cough is one of the most common symptoms. COVID-19 infection related cough includes acute cough, persistent cough and chronic cough, and children with original chronic cough or chronic lung disease can also induce or aggravate symptom of cough after infection, which has a great impact on children's physical and mental health. The treatment for COVID-19 infection related cough vary with the etiology. Improper treatment would delay the patient's condition and increase adverse drug reaction. Currently, there is no guideline or consensus on the diagnosis and treatment of COVID-19 infection related cough in children in China, therefore this consensus is drafted. Referring to the latest international research and the diagnostic and therapeutic strategy for COVID-19 infection (Tenth Edition For Trial Implementation), and combining with clinical diagnosis and treatment experience,the consensus elaborates the pathogenesis and etiology of COVID-19 infection related cough, the use of cough relievers and expectorants, as well as the key points of diagnosis and treatment of different etiological factors. It is expected to provide specific and feasible guidance scheme for pediatricians, general practitioners and clinical pharmacists.

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Objective: To explore the clinical characteristics and treatment of COVID-19 infection in patients with relapsed/refractory B-cell non-Hodgkin lymphoma before and after receiving chimeric antigen receptor T-cell therapy, and study the influencing factors of severe COVID-19 infection in these patients. Methods: The data of 59 patients with relapsed/refractory B-cell non-Hodgkin lymphoma who received chimeric antigen receptor T-cell therapy at the Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology and Department of Hematology, the Second Affiliated Hospital, College of Medicine, Zhejiang University between December 2017 and February 2023, and who were infected with novel coronavirus between December 2022 and February 2023 were retrospectively studied. Patients were divided into light, medium, severe, and critical groups, and the differences between the groups were analyzed using the chi-square test. A univariate logistic regression model was used to evaluate the contribution of each variable and its relationship with severe infection. The chi-square and Fisher's exact tests were used to analyze the differences between the B-cell aplasia and B-cell recovery (BCR) groups. Results: Of the 59 pre- and post-infusion infections, 39 (66.1%) led to mild COVID-19, 9 (15.3%) resulted in moderate COVID-19, 10 (16.9%) resulted in severe COVID-19, and 1 (1.7%) led to critical COVID-19. Moroever, age greater than 55 years, having received autologous hematopoietic stem cell transplantation, progressive disease status, and B-cell aplasia at the time of diagnosis of COVID-19 infection are factors affecting severe infection. Patients with B-cell aplasia had a more severe infection with COVID-19 (P<0.001), a longer duration (P=0.015), a longer antiviral therapy course (P<0.001), and a higher hospitalization rate (P<0.001) than the BCR group. Conclusion: Active prevention and treatment of COVID-19 infection remains a crucial issue requiring urgent attention in managing patients with relapsed/refractory B-cell non-Hodgkin lymphoma treated with chimeric antigen receptor T-cell therapy.

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Abstract Objective We describe the development and structure of a novel mobile application in a mixed model of prenatal care, in the context of the COVID-19 pandemic. Furthermore, we assess the acceptability of this mobile app in a cohort of patients. Methods First, we introduced a mixed model of prenatal care; second, we developed a comprehensive, computer-based clinical record to support our system. Lastly, we built a novel mobile app as a tool for prenatal care. We used Flutter Software version 2.2 to build the app for Android and iOS smartphones. A cross-sectional study was carried out to assess the acceptability of the app. Results A mobile app was also built with the main attribute of being connected in real-time with the computer-based clinical records. The app screens detail information about activities programmed and developed in the prenatal care according to gestational age. A downloadable maternity book is available and some screens show warning signs and symptoms of pregnancy. The acceptability assessment was mostly rated positively regarding the characteristics of the mobile app, by 50 patients. Conclusion This novel mobile app was developed as a tool among pregnant patients to increase the information available about their pregnancies in the provision of a mixed model of prenatal care in the context of the COVID-19 pandemic. It was fully customized to the needs of our users following the local protocols. The introduction of this novel mobile app was highly accepted by the patients.

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RESUMO. A pandemia da Covid-19 levou ao isolamento social grande contingente populacional no Brasil e no mundo. Conforme as mais altas autoridades de saúde internacionais, entre elas a Organização Mundial da Saúde (OMS), os idosos fazem parte do denominado 'grupo de risco' para a doença. Portanto, foram exigidos mais rigor e cuidado entre as pessoas com idade mais avançada, incluindo o isolamento social. Apesar da indiscutível importância dessa medida, os idosos em situação de isolamento social ficaram mais vulneráveis a uma série de agravos, principalmente os de ordem psíquica. O objetivo do presente trabalho é apresentar propostas de atenção psicossocial ao idoso em situação de sofrimento ou vulnerabilidade decorrente do isolamento social. As propostas buscam estimular a memória, a cognição e a psicomotricidade por meio de narrativas, recursos artísticos, Tecnologias da Informação e Comunicação e objetos autobiográficos como, por exemplo, realizar videochamadas, ler, ouvir músicas, contar e relembrar histórias. Em geral, as atividades propostas podem ser coordenadas por profissionais e familiares e adaptadas conforme as características de cada idoso.

RESUMEN. La pandemia de COVID-19 llevó a un gran número de personas en Brasil y en todo el mundo al aislamiento social. Según las principales autoridades sanitarias internacionales, entre ellas la Organización Mundial de la Salud (OMS), las personas mayores forman parte del denominado 'grupo de riesgo' de la enfermedad. De esta forma, se requería más rigor y cuidado entre las personas mayores, incluyendo el aislamiento social. Como es sabido, a pesar de la indiscutible importancia de esta acción, las personas mayores aisladas socialmente fueron más expuestas a una serie de enfermedades, principalmente relacionadas con problemas psíquicos. El objetivo de este trabajo es presentar las propuestas de atención psicosocial para los ancianos en situación de sufrimiento o discapacidad debido al aislamiento social. Las propuestas buscan estimular la memoria, la cognición y la psicomotricidad a través de narraciones, recursos artísticos, tecnologías de la información y comunicación y objetos autobiográficos, como videoconferencias, lectura, escucha de música, narración y recordación de historias. En general, las actividades propuestas pueden ser coordinadas por profesionales y miembros de la familia y adaptadas según las características de cada persona mayor.

ABSTRACT. The COVID-19 pandemic drove a large population contingent in Brazil and worldwide into social isolation. As reported by the highest international health authorities, including the World Health Organization (WHO), the elderly people are part of the so-called 'risk group' for the disease. Thus, more rigor and care were required among elderly people, including social isolation. It is well known that, despite the undeniable importance of this action, elderly people in social isolation were more exposed to a series of illnesses, mainly related to psychic problems. The goal of this paper is to propose psychosocial care for the elderly in a situation of distress, or vulnerability due to social isolation. The ideas seek to induce memory, cognition and psychomotricity through narratives, artistic resources, Information, Communication Technologies and autobiographical objects, such as video calls, reading, listening to music, storytelling and recalling. In general, the proposed activities can be coordinated by professionals and family members and adapted according to the characteristics of each elderly person.

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RESUMO Objetivo comparar os marcadores de alteração na deglutição de pacientes com e sem COVID-19 e estudar as variáveis preditivas de contraindicação da alimentação por via oral em pacientes com necessidade de intubação orotraqueal prolongada. Métodos estudo caso-controle, retrospectivo, com coleta de prontuário de variáveis clínicas e demográficas e da avaliação clínica da deglutição. As variáveis coletadas foram comparadas estatisticamente entre pacientes com COVID-19 (grupo estudo -GE) e sem COVID-19 (grupo-controle - GC). A análise de regressão de robusta de Poisson foi utilizada para avaliar o efeito da COVID-19 e das demais variáveis na contraindicação da alimentação por via oral. Resultados foram incluídos 351 pacientes, 269 no GE e 82 no GC. Pacientes do GE apresentaram menor idade, quando comparados ao GC (50,7 ± 12,8). O tempo total de intubação orotraqueal foi significativamente maior no GE. Os pacientes do GE apresentaram maior prevalência de tosse fraca, disfonia, piores graus de disfagia e maior ocorrência de contraindicação da alimentação por via oral. Na análise bivariada, verificou-se que os pacientes com COVID-19 apresentaram 65% maior probabilidade dessa contraindicação. Entretanto, quando a COVID-19 foi ajustada com outras variáveis clínicas e demográficas, verificou-se que as estas apresentaram maior influência sobre a contraindicação de alimentação por via oral do que a COVID-19. Conclusão a intubação orotraqueal prolongada teve pior efeito nos marcadores de alteração na deglutição e na reintrodução da via oral de pacientes com COVID-19. A idade maior que 60 anos, tempo de intubação orotraqueal maior que cinco dias, reintubação e delirium demonstraram ser preditivas de contraindicação da alimentação por via oral em pacientes intubados.

ABSTRACT Purpose To compare the swallowing alteration markers in patients with and without COVID-19 and to study the predictive variables of oral feeding contraindication in patients requiring prolonged orotracheal intubation. Methods Retrospective case-control study, with medical record data collection of clinical and demographic variables and the clinical evaluation of swallowing. The collected variables were statistically compared between patients with COVID-19 (SG) and without COVID-19 (CG). Robust Poisson regression analysis was used to evaluate the effect of COVID-19 and other variables on oral feeding contraindication. Results 351 patients were included, 269 in the SG and 82 in the CG. Patients in the SG were younger when compared to the CG (50.7 ± 12.8). The total time of orotracheal intubation was significantly longer in the SG. The patients in the SG had a higher prevalence of weak cough, dysphonia, worse degrees of dysphagia and higher occurrence of contraindication of oral feeding. In the bivariate analysis, it was found that patients with COVID-19 were 65% more likely to have oral feeding contraindication. However, when COVID-19 was adjusted with other clinical and demographic variables, it was found that these variables had a greater influence on the contraindication of the oral feeding than the COVID-19. Conclusion Prolonged orotracheal intubation had a worse effect on alteration markers in swallowing and reintroduction of the oral feeding in COVID-19 patients. Age over 60 years, orotracheal intubation time greater than 5 days, reintubation, and delirium were shown to be predictive of oral feeding contraindication in intubated patients.

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INTRODUCTION: Difficult airway is a serious medical emergency that can cause neurological injury and death. It is crucial to be trained and equipped with advanced devices to manage it, especially during the COVID-19 pandemic. OBJECTIVE: To describe the training and experience in difficult airway cases among anesthesiology residents in Colombia during the COVID-19 pandemic. METHODS: This is a descriptive, retrospective, cross-sectional study conducted through a survey using QuestionPro. Program contents, exposure to complex cases, and satisfaction with training in airway management in general patients and COVID-19 patients were explored. Convenience sampling was used, and the study protocol was approved by the Ethics Committee of the National University Hospital of Colombia. RESULTS: This study found that 54.4% of anesthesiology residents reported receiving specific training on the management of difficult airway and advanced airway devices. During the COVID-19 pandemic, most residents reported handling two cases of difficult airway and feeling inadequately prepared. Most hospitals lacked specialized equipment, with videolaryngoscopy being the most commonly used device in suspected or confirmed COVID-19 patients. CONCLUSIONS: In this study, most anesthesiology residents in Colombia have insufficient training in the management of difficult airway and the use of advanced devices.

INTRODUCCIÓN: La vía aérea difícil es una emergencia médica grave que puede causar lesiones neurológicas y la muerte. Es crucial entrenarse y contar con dispositivos avanzados para manejarla, especialmente durante la pandemia de COVID-19. OBJETIVO: Describir el entrenamiento y la experiencia en casos de vía aérea difícil en los residentes de programas de anestesiología de Colombia durante la pandemia de COVID-19. MÉTODOS: Estudio descriptivo, retrospectivo de corte transversal que se realizó mediante una encuesta aplicada a través de QuestionPro. Se exploraron contenidos programáticos, nivel de exposición a casos complejos y satisfacción con el entrenamiento en manejo de la vía aérea en pacientes generales y en pacientes COVID-19. La muestra fue seleccionada a conveniencia y el protocolo del estudio fue aprobado por el Comité de Ética del Hospital Universitario Nacional de Colombia. RESULTADOS: Este estudio encontró que el 54,4% de los residentes de anestesiología informó haber recibido capacitación específica sobre el manejo de la vía aérea difícil y dispositivos avanzados de vía aérea. Durante la pandemia de COVID-19, la mayoría de los residentes informaron haber manejado 2 casos de vía aérea difícil y sentirse inadecuadamente preparados. La mayoría de los hospitales carecían de equipos especializados siendo el videolaringoscopio el dispositivo más comúnmente usado en pacientes sospechosos o confirmados de COVID-19. CONCLUSIONES: En este estudio la mayoría de los residentes de anestesiología en Colombia tienen una capacitación insuficiente en el manejo de vía aérea difícil y en el uso de dispositivos avanzados.