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1.
Ciudad de Buenos Aires; GCBA. Gerencia Operativa de Epidemiología; 15 jul. 2022. f:12 l:25 p. tab, graf.(Boletín Epidemiológico Semanal: Ciudad Autónoma de Buenos Aires, 7, 308).
Monography in Spanish | LILACS, InstitutionalDB, BINACIS, UNISALUD | ID: biblio-1391810

ABSTRACT

Se presenta brevemente la situación mundial y regional de hepatitis virales y de hepatitis de etiología desconocida, con su correspondiente análisis de los casos residentes en la Ciudad de Buenos Aires durante el período 2020-2021. Describe la cobertura de vacunación en los años 2018-2021.


Subject(s)
Hepatitis/diagnosis , Hepatitis/epidemiology , Hepatitis, Viral, Human/diagnosis , Hepatitis, Viral, Human/transmission , Hepatitis, Viral, Human/epidemiology , Disease Notification , Epidemiological Monitoring
6.
Rev. Ciênc. Plur ; 8(2): e24290, mar. 2022. ilus, tab
Article in Portuguese | LILACS, BBO | ID: biblio-1367904

ABSTRACT

Introdução:O Serviço de Assistência Especializada é um serviço responsável pela assistência ambulatorial às pessoas vivendo com HIV/AIDSe Hepatites Virais. Em meio à importância desses serviços, é primordial instituir estratégias de avaliação do seu desempenho.Objetivo:Assim, objetivou-se construir e validar um modelo lógico para o Serviço de Atenção Especializada do município de Natal.Metodologia:Para tanto, desenvolveu-se um estudo metodológico para validação de um modelo lógicoconstruído com técnicas de abordagem qualitativa. Os profissionais participaram da fase de construção e validação do modelo. Para construção do modelo lógico foram realizadas duas técnicas; revisão de literatura para uma construção prévia ao grupo focal eo grupo focal para viabilizar a construção participativa do modelo e posterior validação de conteúdo. Os dados colhidos foram analisados de forma qualitativa, buscando identificar nos discursos, a pertinência dos elementos do modelo, bem como a possível inserção de outros elementos. Resultados:O modelo construído com base na Revisão de literatura foi aprovado por consenso dos participantes, não sendo sugeridas modificações. No caso, a missão, recursos, processos, resultados, contexto foram considerados adequados e o modelo ilustrativo do funcionamento esperado. Conclusões:O modelo lógico pretende viabilizar uma auto avaliação do serviço, auxiliando a administração e os profissionais a identificarem problemas, buscando estratégias de melhoria. Espera-se que a reflexão propiciada no grupo focal possa sensibilizar os profissionais para buscar estratégias de enfrentamento das dificuldades elencadas e aprimoramento dos pontos positivos (AU).


Introduction:The Specialized Care Service is a service responsible for outpatient care for people living with HIV/AIDSand Viral Hepatitis. In the midst of the importance of these services, it is essential to institute performance evaluation strategies.Objective:Thus, the objective was to build and validate a logical model for the Specialized Care Service of the municipality of Natal.Methodology:Therefore, a methodological study was developed to validate a logical model built with qualitative approach techniques. Theprofessionals participated in the model construction and validation phase. To build the logical model, two techniques were performed; literature review for prior construction of the focus group and focus group to enable participatory model construction and subsequent content validation. The collected data were analyzed qualitatively, seeking to identify in the speeches, the pertinence of the model elements, as well as the possible insertion of other elements.Results:The model constructed based on the literature review was approved by consensus of the participants, and no modifications were suggested. In this case, the mission, resources, processes, results, context were considered adequate and the illustrative model of the expected functioning. Conclusions:The logical model aims to enable a self-assessment of the service, helping management and professionals to identify problems, seeking improvement strategies. It is hoped that the reflection provided in the focus group can sensitize professionals to seek strategies to cope with the difficulties listed and improvement of positive points (AU).


Introducción: El Servicio de Asistencia Especializada es un servicio responsable de la atención ambulatoria para personas que viven con VIH / SIDA y Hepatitis Virales. En medio de la importancia de estos servicios, es fundamental establecer estrategias para evaluar su desempeño. Objetivo: Así, el objetivo fue construir y validar un modelo lógico para el Servicio de AtenciónEspecializada del municipio de Natal. Metodología: Para ello se desarrolló un estudio metodológico para validar un modelo lógico construido con técnicas de enfoque cualitativo. Profesionales participaron en la fase de construcción y validación del modelo. Se utilizaron dos técnicas para construir el modelo lógico; revisión de la literatura para una construcción previa al focus group y al focus group que posibilite la construcción participativa del modelo y posterior validación de contenido. Los datos recolectados fueron analizados de manera cualitativa, buscando identificar en los discursos, la pertinencia de los elementos del modelo, así como la posible inserción de otros elementos.Resultados: El modelo construido a partir de la revisión de la literatura fue aprobado por consenso de los participantes, sin que se sugirieran modificaciones. En este caso se consideró adecuado la misión, recursos, procesos, resultados, contexto y el modelo ilustrando el funcionamiento esperado. Conclusiones: El modelo lógico pretende posibilitar una autoevaluación del servicio, ayudando a la dirección y profesionales a identificar problemas, buscando estrategias de mejora. Se espera que la reflexión brindada en el grupo focal pueda sensibilizar a los profesionales para buscar estrategias para enfrentar las dificultades enumeradas y mejorar los puntos positivos (AU).


Subject(s)
Humans , Male , Female , Health Evaluation , HIV , Health Strategies , Basic Health Services , Hepatitis , Organization and Administration , Brazil , Focus Groups , Qualitative Research , Ambulatory Care , Persons
7.
Rev. baiana enferm ; 36: e38071, 2022. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1376461

ABSTRACT

Objetivo: conhecer a produção científica sobre as Infecções Sexualmente Transmissíveis e o acometimento aos homens no sistema prisional. Método: revisão integrativa realizada nas bases de dados SciELO, LILACS, Web of Science e MEDLINE mediante o emprego de seis etapas sistematizadas metodologicamente. Resultados: o cenário das Infecções Sexualmente Transmissíveis entre homens no sistema prisional caracterizou-se pela continuidade da elevação de fatores de risco, vulnerabilização masculina, fragilidade na educação sexual e fez interface com o comportamento, as práticas e as identidades sexuais e os padrões de masculinidade. Apresentou limitação das ações de promoção da saúde e prevenção de agravos, problemas de governança e institucionalização de medidas de enfrentamento, cronicidade das negligências e iniquidades em saúde. Conclusão: a produção científica sobre as Infecções Sexualmente Transmissíveis apontou fragilidades na atenção à saúde e nos níveis de literacia em saúde masculina, que se somam à manutenção da masculinidade hegemônica e ao grave comprometimento dos direitos humanos. Considerações finais: condições precárias da Atenção Primária à Saúde implicam em desestruturação de resposta adequada em momentos de emergências sanitárias.


Objective: to know the scientific production on Sexually Transmitted Infections and the involvement of men in the prison system. Method: integrative review performed in the SciELO, LILACS, Web of Science and MEDLINE databases using six methodologically systematized steps. Results: the scenario of Sexually Transmitted Infections among men in the prison system was characterized by the continuity of the elevation of risk factors, male vulnerability, fragility in sex education and interfaced with behavior, sexual practices and identities and patterns of masculinity. It presented limitation of health promotion actions and disease prevention, governance problems and institutionalization of coping measures, chronicity of health neglects and inequities. Conclusion: the scientific production on Sexually Transmitted Infections pointed out weaknesses in health care and in the levels of literacy in men's health, which are added to the maintenance of hegemonic masculinity and the severe commitment of human rights.


Objective: to know the scientific production on Sexually Transmitted Infections and the involvement of men in the prison system. Method: integrative review performed in the SciELO, LILACS, Web of Science and MEDLINE databases using six methodologically systematized steps. Results: the scenario of Sexually Transmitted Infections among men in the prison system was characterized by the continuity of the elevation of risk factors, male vulnerability, fragility in sex education and interfaced with behavior, sexual practices and identities and patterns of masculinity. It presented limitation of health promotion actions and disease prevention, governance problems and institutionalization of coping measures, chronicity of health neglects and inequities. Conclusion: the scientific production on Sexually Transmitted Infections pointed out weaknesses in health care and in the levels of literacy in men's health, which are added to the maintenance of hegemonic masculinity and the severe commitment of human rights.


Subject(s)
Humans , Male , Prisoners , Sex Education , Sexually Transmitted Diseases , Men's Health , Sexual Health , HIV , Hepatitis/epidemiology
10.
Article in Chinese | WPRIM | ID: wpr-880827

ABSTRACT

OBJECTIVE@#To investigate the role of NDUFA13 inactivation in the pathogenesis of spontaneous hepatitis in mice and explore the possible mechanisms.@*METHODS@#Hepatocyte-specific NDUFA13 knockout (NDUFA13@*RESULTS@#Liver-specific NDUFA13 heterozygous knockout mice were successfully constructed as verified by PCR results. HE staining revealed severe liver damage in both 4- week-old and 2-year-old NDUFA13@*CONCLUSIONS@#Hepatocytes-specific NDUFA13 ablation can trigger spontaneous hepatitis in mice possibly mediated by the activation of ROS/NF-κB/NLRP3 signaling.


Subject(s)
Animals , Hepatitis , Inflammasomes , Mice , NF-kappa B/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein/genetics , Signal Transduction
11.
Rev. baiana saúde pública ; 44(4): 76-92, 20201212.
Article in Portuguese | LILACS | ID: biblio-1379411

ABSTRACT

As infecções virais que acometem o fígado são denominadas hepatites e, geralmente, podem ter cinco etiologias, desde o vírus A ao vírus E. As manifestações clínicas dependem do tipo viral, assim como variam de acordo com a etiologia das doenças, sendo assim, conhecer esses dados é necessário para compreender as variáveis das áreas afetadas. Este artigo visa comparar os dados disponíveis nos sistemas de informações on-line do governo brasileiro. Foi constatada a necessidade de atualização do banco de dados, tendo em vista sua importância para produção científica e elaboração de ações. Este é um estudo transversal, baseado no Departamento de Informática do Sistema Único de Saúde (Datasus) e em documentos oficiais do governo brasileiro, como os boletins epidemiológicos. Foram incluídos aqueles que citaram informações de incidência e/ou prevalência e/ou continham suas relações com características sociais, econômicas ou culturais, com retrospecto de até cinco anos. Entre os resultados, a transmissão das hepatites por via sexual é a predominante no Brasil, assim como foi predominante em todos os estados. O segundo lugar foi variável, sendo no Sul e Sudeste o uso de drogas injetáveis, enquanto no Norte, Nordeste e Centro-Oeste predominou a contaminação por água e alimentos. Contraditoriamente, a hepatite C predomina nas regiões Sul e Sudeste, enquanto nas demais predomina a hepatite B. Compreender os fatores individuais de cada região pode provir o estudo da base de dados, inclusive sendo importante ação de prevenção e promoção da saúde.


Hepatitis refers to viral infections that affect the liver and can usually present five etiologies, from virus A to virus E. The clinical manifestations depend on the viral type, which varies according to the disease etiology. Know these data is therefore necessary to understand the variables of the affected areas. Hence, this article compares the data available in the Brazilian government's online information systems. The database requires updating given its importance for scientific production and policy development. This is a cross-sectional study based on the SUS Informatics Department (DATASUS) and on official documents, such as the epidemiological bulletins. Documents which cited incidence and/or prevalence information and/or contained their relation to social, economic, or cultural characteristics, with a retrospective of up to 5 years, were included. Results show that sexually transmitted Hepatitis predominates in Brazil, as is prevalent in all states. The second place varied: while injecting drug use are prevalent in the South and Southeast, water and food contamination predominate in the North, Northeast, and Midwest. Contradictorily, hepatitis C predominates in the South and Southeast regions, while hepatitis B is prevalent in the remaining ones. Understanding the individual factors of each region can derive from studying the database, including being an important action for prevention and health promotion.


Las infecciones virales que afectan al hígado se denominan hepatitis y, generalmente, pueden tener cinco etiologías desde el virus A hasta el virus E. Teniendo en cuenta que las manifestaciones clínicas van a depender del tipo viral, así como también varían de acuerdo con la etiología de las enfermedades, conocer estos datos son necesarios para comprender las variables de las áreas afectadas. Este artículo pretende comparar los datos disponibles en los sistemas de información online del gobierno brasileño. Se percibió la necesidad de actualizar esa base de datos para demostrar su importancia para la producción científica y elaboración de acciones. Este es un estudio transversal, basado en el Departamento de Informática del Sistema Único de Salud (DATASUS) y los documentos oficiales del gobierno brasileño, como los boletines epidemiológicos. Se incluyeron aquellos que citaron informaciones de incidencia y/o prevalencia y/o contenían sus relaciones con características sociales, económicas o culturales con retrospección de hasta cinco años. Entre las hepatitis, la transmisión por vía sexual es la predominante en Brasil, en todos los estados. El segundo lugar fue variable siendo en el Sur y Sudeste el uso de drogas inyectables, mientras que en el Norte, Nordeste y Centro-Oeste predominaron la contaminación a través de agua y alimentos. En contraste, la hepatitis C predomina en las regiones Sur y Sudeste, mientras que en las demás regiones es predominante la hepatitis B. Comprender los factores individuales de cada región puede ayudar el estudio de la base de datos, inclusive es una importante acción de prevención y promoción de la salud.


Subject(s)
Virus Diseases , Information Systems , Food Contamination , Hepatitis C , Hepatitis/epidemiology , Hepatitis B
12.
Rev. chil. infectol ; 37(5): 531-540, nov. 2020. tab, graf
Article in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1144247

ABSTRACT

Resumen Introducción: Para los pacientes receptores de trasplante hepático (TH) la hepatitis por citomegalovirus (CMV) constituye una entidad de difícil diagnóstico. Nuestro objetivo fue determinar la real incidencia de hepatitis por CMV aplicando técnicas diagnósticas más específicas. Material y Métodos: Estudio retrospectivo/ prospectivo, en un centro de trasplante hepático. Período de estudio: años 2009 al 2019. Se incluyeron los TH que presentaron elementos sugestivos y/o específicos de CMV en la histopatología de la punción biopsia hepática (PBH), a los que se les realizó inmunohistoquimica (IHQ) en la PBH. Población control n = 17. Resultados: 41 casos cumplieron los criterios de inclusión. La IHQ fue positiva en n = 6 (14,6%). En la población control, la IHQ fue negativa en el 100% de los casos. Esto traduce un valor predictor negativo de 100% para la histopatología en el diagnóstico de hepatitis por CMV, con un valor predictor positivo de 14,6%. En 85% de los pacientes con IHQ negativa, hubo diagnósticos alternativos. La terapia antiviral en la fase retrospectiva se indicó en 48% y en la prospectiva en 21%. Conclusiones: Combinar la histopatología con la IHQ optimiza el diagnóstico de hepatitis por CMV; lo que permite la racionalización del uso de antivirales de alto costo y la búsqueda de etiologías diferenciales.


Abstract Background: Cytomegalovirus (CMV) hepatitis constitutes a challenging diagnostic entity in liver transplant (LT) recipients. Aim: To determine the real incidence of CMV hepatitis using more specific diagnostic tools as those currently used before. Methods: Retrospective/prospective study conducted in a hepatic transplant unit from 2009 to 2019. LT recipients with CMV specific or suggestive elements in histopathology of hepatic biopsies were included. Immunohistochemistry (IHQ) was performed in tissue samples of the studied cohort as well as in a control one. Results: 41 patients met the inclusion criteria. IHQ was diagnostic in 6 (14.6%), and was negative in 100% of the control population. The negative predictive value of the histopathology for CMV hepatitis diagnosis was 100% and the positive predictive value was 14.6%. 85% of patients in whom the IHQ was negative had alternative diagnosis Antiviral therapy in the retrospective analysis was indicated in 48% of patients and in 21% of the prospectively analyzed cohort. Conclusions: Histopathology and IHQ combination improves the diagnostic accuracy of CMV hepatitis which translates into a rational us of expensive antiviral therapy and to search for differential diagnosis


Subject(s)
Humans , Liver Transplantation , Cytomegalovirus Infections/diagnosis , Antiviral Agents/therapeutic use , Prospective Studies , Retrospective Studies , Cytomegalovirus , Hepatitis/drug therapy
13.
Article in Chinese | WPRIM | ID: wpr-828882

ABSTRACT

OBJECTIVE@#Abnormalities of liver-related indices are common in ICU patients, but the effects of cholestasis and hypoxic hepatitis in critically ill patients remains unclarified. The purpose of this study was to investigate the effects of cholestasis and hypoxic liver dysfunction on the prognosis of ICU patients.@*METHODS@#A retrospective study was conducted based on the data of patients admitted to the ICU for the first time between 2001 and 2011 archived in the MIMIC-Ⅲ database. The patients were divided into cholestasis, hypoxic hepatitis and control groups, and their 28-day case fatality rate as the primary outcome was compared among the groups.@*RESULTS@#A total of 5852 ICU patients were included in the analysis. The incidence of cholestasis and hypoxic liver dysfunction was 31.9% (1869/5852) and 17.9% (1046/5852), respectively. There was no significant difference in 28-day case fatality rate between cholestasis group and the control group. Compared with the control group, the patients with hypoxic hepatitis had a significantly higher 28-day case fatality rate (46% 35%, < 0.01), a higher hospital case fatality rate (40% 31%, < 0.01), and a higher ICU case fatality rate (35.7% 22.2%, < 0.01). Logistic regression analysis showed that lactic acid (LAC), aspartate transaminase (AST), and international standard ratio (INR) were independent risk factors for 28-day case fatality rate.@*CONCLUSIONS@#The incidence of cholestatic liver dysfunction is higher than that of hypoxic hepatitis, but it does not increase the 28-day case fatality rate of the ICU patients, suggesting that cholestatic liver dysfunction may be the early adaptation of the liver to critical diseases.


Subject(s)
Cholestasis , Hepatitis , Humans , Intensive Care Units , Prognosis , Retrospective Studies
15.
Article in English | WPRIM | ID: wpr-811418

ABSTRACT

PURPOSE: To evaluate the effect of gluten-free diet (GFD) on hepatitis B surface antibody (HBsAb) concentrations among previously immunized pediatric celiac disease (CD) subjects.METHODS: We retrospectively evaluated pediatric CD subjects in serological remission who were previously immunized for hepatitis B virus as infants. The temporal relationship between HBsAb concentration, the amount of time on a GFD, and age were evaluated.RESULTS: Overall, 373 CD subjects were analyzed: 156 with HBsAb sampled prior to GFD initiation and 217 after initiation of a GFD and in serological remission. Median age at HBsAb concentration measurement for those before and after GFD initiation was 5.3 years (interquartile range [IQR], 3.1–9.2 years) and 7.6 years (IQR, 5.4–10.9 years), respectively (p<0.001). There was no sex difference between the groups. The median time of HBsAb measurement was 2 months (IQR, 0–5.7 months) before and 12.8 months (IQR, 5.3–30.3 months) after initiation of GFD. The HBsAb concentration was low in 79 (50.6%) and 121 (55.7%) subjects before and after GFD initiation, respectively (p=0.350). Age was inversely associated with low HBsAb concentrations. Neither being on a GFD nor sex was associated with low HBsAb concentrations.CONCLUSION: Adherence to a GFD does not affect HBsAb concentration in children with CD. Age is inversely associated with HBsAb concentration.


Subject(s)
Antibodies , Celiac Disease , Child , Diet, Gluten-Free , Glutens , Hepatitis B virus , Hepatitis B , Hepatitis , Humans , Immunization , Infant , Retrospective Studies , Sex Characteristics
16.
Article in English | WPRIM | ID: wpr-811412

ABSTRACT

Giant cell hepatitis with autoimmune hemolytic anemia (AHA) is a rare disease of infancy characterized by the presence of both Coombs-positive hemolytic anemia and progressive liver disease with giant cell transformation of hepatocytes. Here, we report a case involving a seven-month-old male infant who presented with AHA followed by cholestatic hepatitis. The clinical features included jaundice, pallor, and red urine. Physical examination showed generalized icterus and splenomegaly. The laboratory findings suggested warm-type AHA with cholestatic hepatitis. Liver biopsy revealed giant cell transformation of hepatocytes and moderate lobular inflammation. The patient was successfully treated with four doses of rituximab. Early relapse of hemolytic anemia and hepatitis was observed, which prompted the use of an additional salvage dose of rituximab. He is currently in clinical remission.


Subject(s)
Anemia, Hemolytic , Anemia, Hemolytic, Autoimmune , Biopsy , Giant Cells , Hepatitis , Hepatocytes , Humans , Infant , Inflammation , Jaundice , Liver , Liver Diseases , Male , Pallor , Physical Examination , Rare Diseases , Recurrence , Rituximab , Splenomegaly
17.
Article in English | WPRIM | ID: wpr-811068

ABSTRACT

PURPOSE: The incidence of drug-induced liver injury (DILI) has been increasing; however, few algorithms are available to identify DILI in electronic health records (EHRs). We aimed to identify and evaluate DILI with an appropriate screening algorithm.METHODS: We collected data from 3 university hospitals between June 2015 and May 2016 using our newly developed algorithm for identifying DILI. Among patients with alanine transferase (ALT) ≤ 120 IU/L and total bilirubin (TB) ≤ 2.4 mg/dL in blood test results within 48 hours of admission, those who either had 1) ALT > 120 IU/L and TB > 2.4 mg/dL or 2) ALT > 200 IU/L at least once during hospitalization were identified. After excluding patients with liver disease-related diagnosis at discharge, medical records were retrospectively reviewed to evaluate epidemiological characteristics of DILI.RESULTS: The total number of inpatients was 256,598, of whom 1,100 (0.43%) were selected by the algorithm as suspected DILI. Subsequently, 365 cases (0.14% of total inpatients, 95% confidence interval, 0.13–0.16) were identified as DILI, yielding a positive predictive value of 33.1%. Antibiotics (n = 214, 47.2%) were the major class of causative drug followed by chemotherapeutic agents (n = 87, 19.2%). The most common causative drug was piperacillin-tazobactam (n = 38, 8.4%); the incidence of DILI by individual agent was highest for methotrexate (19.4 cases/1,000 patients administered the drug). Common reasons for excluding suspected DILI cases were ischemic hepatitis and postoperative liver dysfunction.CONCLUSIONS: Using our EHR-based algorithm, we identified that approximately 0.14% of patients developed DILI during hospitalization. Further studies are needed to modify criteria for more accurate identification of DILI.


Subject(s)
Alanine , Anti-Bacterial Agents , Bilirubin , Diagnosis , Chemical and Drug Induced Liver Injury , Drug-Related Side Effects and Adverse Reactions , Electronic Health Records , Hematologic Tests , Hepatitis , Hospitalization , Hospitals, University , Humans , Incidence , Inpatients , Liver , Liver Diseases , Mass Screening , Medical Records , Methotrexate , Pharmacoepidemiology , Retrospective Studies , Transferases
18.
Article in English | WPRIM | ID: wpr-810952

ABSTRACT

BACKGROUND: Prophylaxis for hepatitis B virus (HBV) recurrence is essential after liver transplantation (LT) in HBV-associated recipients. We conducted real-world analysis of HBV prophylaxis after LT in the Korean population.METHODS: Korean Organ Transplantation Registry (KOTRY) database and additionally collected data (n = 326) were analyzed with special reference to types of HBV prophylaxis.RESULTS: The study cohort comprised 267 cases of living-donor LT and 59 cases of deceased-donor LT. Hepatocellular carcinoma (HCC) was diagnosed in 232 (71.2%) of these subjects. Antiviral agents were used in 255 patients (78.2%) prior to LT. HBV DNA was undetectable in 69 cases (21.2%) and detectable over wide concentrations in the other 257 patients (78.8%) prior to LT. Polymerase chain reaction analysis of the store blood samples detected HBV DNA in all patients, with 159 patients (48.9%) showing concentrations > 100 IU/mL. Post-transplant HBV regimens during the first year included combination therapy in 196 (60.1%), hepatitis B immunoglobulin (HBIG) monotherapy in 121 (37.1%), and antiviral monotherapy in 9 (2.8%). In the second post-transplant year, these regimens had changed to combination therapy in 187 (57.4%), HBIG monotherapy in 112 (34.4%), and antiviral monotherapy in 27 (8.3%). Trough antibody to hepatitis B surface antigen titers > 500 IU/mL and >1,000 IU/mL were observed in 61.7% and 25.2%, respectively. The mean simulative half-life of HBIG was 21.6 ± 4.3 days with a median 17.7 days. Up to 2-year follow-up period, HCC recurrence and HBV recurrence developed in 18 (5.5%) and 6 (1.8%), respectively. HCC recurrence developed in 3 of 6 patients with HBV recurrence.CONCLUSION: Combination therapy is the mainstay of HBV prophylaxis protocols in a majority of Korean LT centers, but HBIG was often administered excessively. Individualized optimization of HBIG treatments using SHL is necessary to adjust the HBIG infusion interval.


Subject(s)
Antiviral Agents , Carcinoma, Hepatocellular , Cohort Studies , DNA , Follow-Up Studies , Half-Life , Hepatitis B Surface Antigens , Hepatitis B virus , Hepatitis B , Hepatitis , Humans , Immunoglobulins , Korea , Liver Transplantation , Liver , Organ Transplantation , Polymerase Chain Reaction , Recurrence , Transplants
20.
Article in English | WPRIM | ID: wpr-826314

ABSTRACT

BACKGROUND@#Physical activity (PA) that includes an accumulated exercise regimen that meets or exceeds a certain intensity reduces intrahepatic fat, leading to the improvement of nonalcoholic fatty liver disease (NAFLD) in afflicted patients. However, whether an increase in comprehensive PA, including activities of daily living, contributes to ameliorating the pathophysiology of NAFLD remains unclear. This study aimed to examine whether PA improves liver function in patients with NAFLD.@*METHODS@#The study included 45 patients with NAFLD who underwent follow-up examinations at least 6 months-but no later than 1 year-after their baseline examinations. The patients were interviewed about their daily activities and exercise habits to determine whether they had engaged in at least 3 metabolic equivalents (METs) per day during the previous 6 months; the quantity of PA, expressed in Ekusasaizu (Ex) units, was calculated as METs multiplied by hours. Patients who had achieved at least a 1-Ex increase in PA per week compared to baseline at the time of their follow-up interview (the PA increase group) were compared to those whose PA was the same or lower at the time of follow-up (the PA non-increase group).@*RESULTS@#There were no significant changes in all blood and biochemical parameters in the PA non-increase group at the time of follow-up when compared with baseline levels. In the PA increase group, aspartate aminotransferase, alanine aminotransferase, and γ-guanosine triphosphate levels were all significantly lower at follow-up than they were at baseline. Body weight did not change significantly from baseline to follow-up in both groups.@*CONCLUSIONS@#In the present study, hepatic inflammation improvement was accompanied by increased PA but not decreased body weight. Increasing PA may be effective for the improvement of hepatic inflammation even without body weight loss. Our results indicate the effectiveness of PA monitoring for the management of NAFLD.@*TRIAL REGISTRATION@#UMIN-CTR, UMIN000038530.


Subject(s)
Activities of Daily Living , Adult , Aged , Aged, 80 and over , Body Weight , Exercise , Female , Hepatitis , Humans , Male , Middle Aged , Non-alcoholic Fatty Liver Disease , Weight Loss , Young Adult
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