ABSTRACT
SUMMARY: A great deal of attention of air pollution on respiratory health is increasing, particularly in relation to haze days. It is that exposure to cigarette smoke augments the toxicity of common air contaminants, thereby increasing the complexity of respiratory diseases. Although there are various mechanisms involved to respiratory diseases caused or worsen by cigarette smoking, in which the role of AQPs in the lung with regard to fluid homeostasis still remains elusive. In this paper, we copied the rat models based on smoke generator, and investigated the morphological changes of mucosa and related functions depending on the balance of lining liquid of alveoli via AQPs expression. Compared with normal group, weak labelling of AQP1 and AQP5 protein abundance were clearly detected in the corresponding part of smoke exposure groups compared with normal group. Hence, it is suggested that the contribution of AQPs in the lung is diminished, thereby causing perturbed balancing between resorptive and secretory fluid homeostasis under cigarette smoking.
Cada vez se presta más atención a la contaminación del aire en la salud respiratoria, particularmente, en relación con los días de neblina. En consecuencia la exposición al humo del cigarrillo aumenta la toxicidad de los contaminantes comunes del aire, lo que además aumenta la complejidad de las enfermedades respiratorias. Aunque existen varios mecanismos involucrados en las enfermedades respiratorias causadas o empeoradas por el tabaquismo, en las que el papel de las AQP en el pulmón respecto a la homeostasis de líquidos sigue siendo difícil de alcanzar. En este artículo, copiamos los modelos de rata basados en el generador de humo e investigamos los cambios morfológicos de la mucosa y las funciones relacionadas según el equilibrio del líquido de revestimiento de los alvéolos a través de la expresión de AQP. En comparación con el grupo normal, se detectó claramente un etiquetado débil de la abundancia de proteínas AQP1 y AQP5 en la parte correspondiente de los grupos de exposición al humo en comparación con el grupo control. Por lo tanto, se sugiere que la contribución de las AQP en el pulmón está disminuida, provocando así un equilibrio perturbado entre la homeostasis del líquido secretor y de reabsorción bajo el hábito de fumar cigarrillos.
Subject(s)
Animals , Rats , Respiratory System/pathology , Cigarette Smoking/adverse effects , Respiratory System/drug effects , Body Fluids/metabolism , Immunohistochemistry , Microscopy, Electron , Rats, Sprague-Dawley , Aquaporins/metabolism , Homeostasis , Lung/drug effects , Lung/pathologyABSTRACT
Psoríase é uma dermatose de caráter inflamatório ligado a diversas composições do ser, sendo estas a genética, o sistema imune, o ambiente e o estado mental do paciente, apresentando evidências de ser um quadro clínico multifacetado. A composição da medicina psicossomática empenha-se na relação mental e emocional e do corpo, sendo importante mostrar a relação desta com a psoríase. Por isso, busca-se avaliar as evidências disponíveis na literatura sobre a relação entre a psoríase e os aspectos psicossomáticos. Foi realizado uma a revisão de literatura, por meio de seleção de artigos das base de dados Medical Literature Analysis and Retrieval System Online (PubMed/Medline), biblioteca virtual em saúde Scientific Electronic Library Online (SciElo), UpToDate e Google acadêmico. A busca por artigos científicos resultou em 20 artigos selecionados. Foi possível concluir, que há estudos fundamentados correlacionando a medicina psicossomática e a psoríase, além de que diversos fatores que afetam a homeostase corporal, provocam alterações nervosas, e consequentemente afetam as células da pele. Além disso, foi encontrado evidências que a estigmatização que os pacientes sofrem influenciam no aumento da gravidade da doença, sendo necessário a realização de um tratamento psico cognitivo-comportamental juntamente com o tratamento dos sinais e sintomas gerais da doença. Desta forma, o presente trabalho pôde olhar para a patologia com um olhar ampliado relacionado ao aspecto mental e emocional o que promove melhor compreensão e as consequências disto são a maior capacidade de intervenção sobre a psoríase.
Psoriasis is an inflammatory dermatosis linked to several compositions of the being, which are genetics, the immune system, the environment and the patient's mental state, that is, it shows evidence of being a multifaceted clinical picture. Since the composition of psychosomatic medicine is committed to the relationship between the mental, emotional, and body, it is important to show its relationship with psoriasis. Therefore, we sought to evaluate the available evidence in the literature on the relationship between psoriasis and psychosomatic aspects. A literature review was conducted by selecting articles from the Medical Literature Analysis and Retrieval System Online (PubMed/Medline), Scientific Electronic Library Online (SciElo), UpToDate and Google Scholar databases. The search for scientific articles resulted in 20 selected articles. It was possible to conclude that there are well-founded studies correlating psychosomatic medicine and psoriasis, and that several factors that affect the body's homeostasis cause nervous alterations, and consequently affect the skin cells. Moreover, it was found evidence that the stigmatization that patients suffer influences the increase of the severity of the disease, being necessary the realization of a psycho cognitive-behavioral treatment along with the treatment of the general signs and symptoms of the disease. Thus, the present work could look at the pathology with a broader view related to the mental and emotional aspect, which promotes better understanding and the consequences of this are a greater ability to intervene on psoriasis.
La psoriasis es una dermatosis inflamatoria vinculada a varias composiciones del ser, que son la genética, el sistema inmunitario, el medio ambiente y el estado mental del paciente, es decir, muestra evidencias de ser un cuadro clínico multifacético. Dado que la composición de la medicina psicosomática está comprometida con la relación entre lo mental, lo emocional y el cuerpo, es importante mostrar su relación con la psoriasis. Por lo tanto, se buscó evaluar la evidencia disponible en la literatura sobre la relación entre la psoriasis y los aspectos psicosomáticos. Se realizó una revisión bibliográfica seleccionando artículos de las bases de datos Medical Literature Analysis and Retrieval System Online (PubMed/Medline), Scientific Electronic Library Online (SciElo), UpToDate y Google Scholar. La búsqueda de artículos científicos dio como resultado 20 artículos seleccionados. Se pudo concluir que existen estudios bien fundamentados que correlacionan la medicina psicosomática y la psoriasis, y que diversos factores que afectan a la homeostasis del organismo provocan alteraciones nerviosas y, en consecuencia, afectan a las células de la piel. Además, se encontraron evidencias de que la estigmatización que sufren los pacientes influye en el aumento de la gravedad de la enfermedad, siendo necesaria la realización de un tratamiento psico cognitivo- conductual junto con el tratamiento de los signos y síntomas generales de la enfermedad. Así, el presente trabajo pudo contemplar la patología con una visión más amplia relacionada con el aspecto mental y emocional, lo que favorece una mejor comprensión y las consecuencias de ello son una mayor capacidad de intervención sobre la psoriasis.
Subject(s)
Psoriasis/diagnosis , Psoriasis/pathology , Psoriasis/therapy , Psychosomatic Medicine , Psychological Distress , Skin/pathology , Skin Diseases/pathology , Review , Database , HomeostasisABSTRACT
Esta é uma pesquisa qualitativa, em formato de ensaio, que realiza o estudo comparado de duas obras literárias, de A. Von Chamisso e E. T. A. Hoffmann, e de uma anotação do diário deste último para problematizar a repercussão de algumas formas de desestabilizações do Eu na dinâmica psíquica da neurose. O foco dos textos referidos está no fenômeno do duplo na sua forma negativizada, isto é, como o desaparecimento da imagem exterior que dá suporte ao Eu. As ausências da sombra e do reflexo são entendidas como representações metafóricas de uma alteração do Eu que engendra repercussões importantes na homeostase psíquica, sobretudo nas relações sociais de troca. Explora-se daí a menção no diário de Hoffmann de instrumentos ópticos para interrogar o uso desses aparelhos como modelos metapsicológicos na psicanálise. Salienta-se, ainda, a participação de processos de natureza estética na dinâmica psíquica do infamiliar, tomando como referência a ligação entre o conto de Hoffmann e o relato de Stendhal sobre a sua estadia em Florença.(AU)
This is a qualitative research, in essay format, which performs the comparative study of two literary works, by A. Von Chamisso and E. T. A. Hoffmann, and an annotation in the latter's diary to problematize the repercussion of some forms of destabilization of the Ego's in the psychic dynamics of neurosis. The focus of the referred texts is on the phenomenon of the double in its negative form, that is, as the disappearance of the outer image that supports the Ego. The absences of the shadow and the reflection are understood as metaphorical representations of an alteration of the Ego that generates important repercussions on psychic homeostasis, above all in social relationships of exchange. Thus, we analyze the mention of optical instruments in Hoffmann's diary to question the use of these devices as metapsychological models in psychoanalysis. Note, also, the participation of processes of aesthetic nature in the psychic dynamics of the uncanny, taking as reference the connection between Hoffmann's short story and Stendhal's account of his stay in Florence.(AU)
Este ensayo cualitativo realiza un estudio comparativo de dos obras literarias de A. Von Chamisso y de E. T. A. Hoffmann, junto con una anotación en el diario de este último para problematizar la repercusión de algunas formas de desestabilizaciones de la función del Yo en la dinámica psíquica de la neurosis. Los textos se centran en el fenómeno del doble en su forma negativa, como la desaparición de la imagen exterior que sostiene el Yo. Se entienden las ausencias de la penumbra y el reflejo como una representación metafórica de una alteración de la función del Yo que genera importantes repercusiones en la regulación psíquica, sobre todo en las relaciones de intercambio social. Se analiza la presencia en el diario de Hoffmann de instrumentos ópticos para discutir el uso de estos dispositivos como modelos metapsicológicos en psicoanálisis. Se destaca la reverberación de procesos de naturaleza estética en la dinámica psíquica de lo ominoso, tomando como referencia la conexión entre el cuento de Hoffmann y el relato de Stendhal sobre su estancia en Florencia.(AU)
Subject(s)
Humans , Psychoanalysis , Family , Literature , Narcissism , Personal Satisfaction , Personality Development , Psychology , Psychosexual Development , Psychosomatic Medicine , Regression, Psychology , Self Concept , Social Alienation , Stress, Psychological , Sublimation, Psychological , Awareness , Superego , Unconscious, Psychology , Behavioral Sciences , Behavioral Symptoms , Body Image , Letter , Consciousness , Intuition , Metaphor , Diary , Essay , Affect , Death , Narration , Comprehension , Dependency, Psychological , Depersonalization , Ego , Extraversion, Psychological , Fantasy , Problem Behavior , Metacognition , Romanticism , Graphic Novel , Folklore , Frailty , Freudian Theory , Germany , Homeostasis , Identification, Psychological , Imagination , Individuation , Inhibition, Psychological , Linguistics , Loneliness , Mental Processes , Oedipus ComplexABSTRACT
Envelhecer compreende um fenômeno complexo, natural e irreversível, que submete o organismo a inúmeras alterações nos processos biológicos, fisiológicos, ambientais, psicológicos, comportamentais e sociais. Esse processo é caracterizado por um declínio gradual dos mecanismos homeostáticos do organismo, intimamente relacionados com o estado senescente. A senescência, quando diz respeito ao sistema imunológico, é denominada de imunossenescência, que pode ser definida como uma parada estável do ciclo celular associada a mudanças, com uma resposta que limita a proliferação de células envelhecidas ou danificadas. A autofagia está diretamente relacionada com a manutenção do fenótipo senescente, em que a atividade autofágica exerce um papel essencial e ativo na influência da biossíntese de proteínas e organelas. Essa via é regulada naturalmente pela proteína mTOR e quimicamente pelo fármaco rapamicina. Assim, pretendemos investigar: (1) as alterações no perfil corporal e hematimêtrico dos animais ao longo do tratamento com rapamicina; (2) avaliar o perfil de citocinas; (3) observar as modificações histológicas em órgãos linfoides primários e secundário; (4) analisar as populações de células linfoides e mieloides; e (5) avaliar a capacidade proliferativa de linfócitos in vitro. Camundongos SAMP-8 e SAMR-1 foram tratados com rapamicina durante dois meses. A mensuração da massa corporal e análises hematológicas foram realizadas antes e durante o tratamento. Amostras de soro, medula óssea, timo e baço foram analisados em ensaios de ELISA, histologia, população e subpopulações de células. Alterações na massa corporal, parâmetros hematológicos e celularidade de células foram nítidas entre os dois modelos utilizados. Diferenças também foram percebidas na detecção de citocinas IL-1ß. IL-6 e TNF-α, com resultados significantes nas amostras de baço, timo e medula óssea. As citocinas IL-7 e IL-15 apresentaram diferenças de secreção entre os grupos, sendo a primeira maior detectada em camundongos com senescência acelerada tratados com rapamicina. Em nossa análise histológica observamos que os camundongos SAM-P8 apresentaram involução tímica. E nas subpopulações de linfócitos T do baço, células TCD4+ e TCD8+ estavam, respectivamente, em maior e menor quantidade nos camundongos SAM-P8 tratados com rapamicina. Dessa forma, o camundongo da linhagem SAM-P8 é um excelente modelo para se estudar as alterações da senescência, em que o mesmo apresenta características fisiológicas distintas dos camundongos utilizados como controle (SAM-R1). Além disso, verificamos que a dose de rapamicina empregada não desencadeou alterações que pudessem comprometer a resposta imunológica desses camundongos, bem como na possibilidade de atuar na resposta contra os efeitos complexos do envelhecimento
Aging comprises a complex, natural, and irreversible phenomenon, which subjects the organism to countless alterations in biological, physiological, environmental, psychological, behavioral, and social processes. This process is characterized by a gradual decline in the organism's homeostatic mechanisms, closely related to senescence effects. Senescence, when it concerns the immune system, is called immunosenescence, which can be defined as a stable cell cycle arrest associated with changes and is a response that limits the proliferation of aged or damaged cells. Autophagy is a genetically regulated, conserved cellular process and a metabolic pathway essential for maintaining cellular homeostasis, which plays a constitutive and active role in controlling the biosynthesis of proteins and organelles. This pathway is regulated naturally by mTOR or chemically by the drug rapamycin, having a direct relationship with cellular homeostasis and maintenance of the senescent phenotype. Thus, we intend to investigate: (1) the changes in the body and hematimetic profile of the animals throughout the rapamycin treatment; (2) evaluate the cytokine profile; (3) observe histological changes in primary and secondary lymphoid organs; (4) analyze lymphoid and myeloid cell populations; and (5) evaluate the proliferative capacity of lymphocytes in vitro. SAMP-8 and SAMR-1 mice were treated with rapamycin for two months. Body mass measurement and hematological analyses were performed before and during treatment. Serum, bone marrow, thymus and spleen samples were analyzed in ELISA assays, histology, cell population and subpopulations. Changes in body mass, hematological parameters, and cellularity were clear between the two models used. Differences were also noticed in the detection of cytokines IL-1ß. IL-6 and TNF-α, with significant results in the spleen, thymus and bone marrow samples. The cytokines IL-7 and IL-15 showed differences in secretion between groups, the former being higher detected in mice with accelerated senescence treated with rapamycin. In our histological analysis we observed that SAM-P8 mice showed thymic involution. And in the spleen T-lymphocyte subpopulations, TCD4+ and TCD8+ cells were, respectively, in higher and lower quantities in SAM-P8 mice treated with rapamycin. Thus, the SAM-P8 mouse is an excellent model to study the changes of senescence, since it presents physiological characteristics different from the control mice (SAM-R1). Furthermore, we verified that the dose of rapamycin used did not trigger changes that could compromise the immune response of these mice, as well as the possibility of acting in the modulatory response against the complex effects of aging
Subject(s)
Animals , Male , Mice , Aging , Sirolimus/adverse effects , Immunosenescence , Autophagy/immunology , In Vitro Techniques/methods , Enzyme-Linked Immunosorbent Assay/instrumentation , Pharmaceutical Preparations/administration & dosage , T-Lymphocyte Subsets/classification , HomeostasisABSTRACT
Abstract Diabetes mellitus (DM) is a non-communicable disease throughout the world in which there is persistently high blood glucose level from the normal range. The diabetes and insulin resistance are mainly responsible for the morbidities and mortalities of humans in the world. This disease is mainly regulated by various enzymes and hormones among which Glycogen synthase kinase-3 (GSK-3) is a principle enzyme and insulin is the key hormone regulating it. The GSK-3, that is the key enzyme is normally showing its actions by various mechanisms that include its phosphorylation, formation of protein complexes, and other cellular distribution and thus it control and directly affects cellular morphology, its growth, mobility and apoptosis of the cell. Disturbances in the action of GSK-3 enzyme may leads to various disease conditions that include insulin resistance leading to diabetes, neurological disease like Alzheimer's disease and cancer. Fluoroquinolones are the most common class of drugs that shows dysglycemic effects via interacting with GSK-3 enzyme. Therefore, it is the need of the day to properly understand functions and mechanisms of GSK-3, especially its role in glucose homeostasis via effects on glycogen synthase.
Resumo O diabetes mellitus (DM) é uma doença não transmissível em todo o mundo, na qual existe nível glicêmico persistentemente alto em relação à normalidade. O diabetes e a resistência à insulina são os principais responsáveis pelas morbidades e mortalidades de humanos no mundo. Essa doença é regulada principalmente por várias enzimas e hormônios, entre os quais a glicogênio sintase quinase-3 (GSK-3) é uma enzima principal e a insulina é o principal hormônio que a regula. A GSK-3, que é a enzima-chave, normalmente mostra suas ações por vários mecanismos que incluem sua fosforilação, formação de complexos de proteínas e outras distribuições celulares e, portanto, controla e afeta diretamente a morfologia celular, seu crescimento, mobilidade e apoptose do célula. Perturbações na ação da enzima GSK-3 podem levar a várias condições de doença que incluem resistência à insulina que leva ao diabetes, doenças neurológicas como a doença de Alzheimer e câncer. As fluoroquinolonas são a classe mais comum de drogas que apresentam efeitos disglicêmicos por meio da interação com a enzima GSK-3. Portanto, é necessário hoje em dia compreender adequadamente as funções e mecanismos da GSK-3, principalmente seu papel na homeostase da glicose via efeitos na glicogênio sintase.
Subject(s)
Humans , Insulin Resistance , Diabetes Mellitus , Glycogen Synthase Kinase 3 , Glucose , HomeostasisABSTRACT
El retículo endoplásmico es un organelo abundante, dinámico y sensor de energía. Sus abundantes membranas, rugosa y lisa, se encuentran distribuidas en diferentes proporciones dependiendo del linaje y requerimiento celular. Su función es llevar a cabo la síntesis de proteínas y lípidos, y es el almacén principal de Ca2+ intracelular. La sobrecarga calórica y la glucolipotoxicidad generada por dietas hipercalóricas provoca la alteración del retículo endoplásmico, activando la respuesta a proteínas mal plegadas (UPR, Unfolded Protein Response, por sus siglas en inglés) como reacción al estrés celular relacionado con el retículo endoplásmico y cuyo objetivo es restablecer la homeostasis del organelo al disminuir el estrés oxidante, la síntesis de proteínas y la fuga de Ca2+. Sin embargo, durante un estrés crónico, la UPR induce formación de especies reactivas de oxígeno, inflamación y apoptosis, exacerbando el estado del retículo endoplásmico y propagando un efecto nocivo para los demás organelos. Es por ello que el estrés del retículo endoplásmico se ha considerado un inductor del inicio y desarrollo de enfermedades metabólicas, incluido el agravamiento de COVID-19. Hasta el momento, existen pocas estrategias para reestablecer la homeostasis del retículo endoplásmico, las cuales son dirigidas a los sensores que desencadenan la UPR. Por tanto, se justifica con urgencia la identificación de nuevos mecanismos y terapias novedosas relacionadas con mitigar el impacto del estrés del retículo endoplásmico y las complicaciones asociadas.
The endoplasmic reticulum is an abundant, dynamic and energy-sensing organelle. Its abundant membranes, rough and smooth, are distributed in different proportions depending on the cell lineage and requirement. Its function is to carry out protein and lipid synthesis, and it is the main intracellular Ca2+ store. Caloric overload and glycolipotoxicity generated by hypercaloric diets cause alteration of the endoplasmic reticulum, activating the Unfolded Protein Response (UPR) as a reaction to cellular stress related to the endoplasmic reticulum and whose objective is to restore the homeostasis of the organelle by decreasing oxidative stress, protein synthesis and Ca2+ leakage. However, during chronic stress, the UPR induces reactive oxygen species formation, inflammation and apoptosis, exacerbating the state of the endoplasmic reticulum and propagating a deleterious effect on the other organelles. This is why endoplasmic reticulum stress has been considered an inducer of the onset and development of metabolic diseases, including the aggravation of COVID-19. So far, few strategies exist to reestablish endoplasmic reticulum homeostasis, which are targeted to sensors that trigger UPR. Therefore, the identif ication of new mechanisms and novel therapies related to mitigating the impact of endoplasmic reticulum stress and associated complications is urgently warranted.
Subject(s)
Humans , Dietary Carbohydrates/adverse effects , Dietary Fats/adverse effects , Endoplasmic Reticulum/metabolism , Endoplasmic Reticulum Stress/physiology , COVID-19/complications , Metabolic Diseases/etiology , COVID-19/therapy , HomeostasisABSTRACT
El riñón es un órgano clave para mantener el balance "homeostasis" del medio interno (agua, electrolitos, equilibrio ácido básico y el equilibrio osmótico), depura la sangre de productos de desechos metabólicos endógenos y exógenos, regula el volumen circulante efectivo y la presión arterial, y sintetiza la eritropoyetina y la vitamina D. Todas estas funciones se ejecutan en el nefrón que constituye la unidad funcional renal
Subject(s)
Epidemiologic Studies , Epidemiologic Measurements , Epidemiological Monitoring , Arterial Pressure , Homeostasis , KidneyABSTRACT
Objetivo: Avaliar os benefícios da técnica Homeostase Quântica Informacional (HQI) sobre a saúde física e emocional de pessoas adultas. Métodos: Estudo experimentalrandomizado quali-quantitativo com grupo controle, com pré-teste e pós-teste, realizado na cidade de Campinas, São Paulo, Brasil. Obtiveram-se os dados entre julho e setembro de 2018 com 50 adultos na faixa etária de 45 a 60 anos, e os instrumentos utilizados avaliaram variáveis de natureza sociodemográfica, de saúde física e emocional. Para análise dos dados utilizou-se o teste qui-quadrado ou o teste exato de Fisher. Para comparação das variáveis numéricas entre os dois grupos utilizou-se o teste de Mann-Whitney e para comparação das variáveis categóricas utilizou-se o teste de Cochran seguido do teste de McNemar. O nível de significância adotado para os testes estatísticos ficou ajustado em p<0,05 e para os dados qualitativos utilizou-se a análise de conteúdo. Resultados: Os resultados mostraram ganhos estatisticamente significantes nos indivíduos do Grupo 1, que receberam o tratamento de HQI, nas avaliações para atividade física (p=0,046), escore de ansiedade (p=0,013), de sofrimento emocional (p=0,008 e p=0,019) e de tontura (p=0,021), quando comparados com o Grupo 2, controle. Conclusão: Os dados obtidos permitem afirmar que a HQI proporciona benefícios para a saúde física e emocional de pessoas adultas. Bem como o seu emprego poderia tornar melhor o dia a dia das pessoas, diminuindo o custo de tratamentos prolongados e onerosos.
Objective: To assess the benefits of the Quantum Information Homeostasis (QIH) technique for the physical and emotional health of adults. Methods: A qualitative and quantitative randomized experimental study with a control group, pre-test and posttest was carried out in the city of Campinas, São Paulo. Data were collected between July and September 2018 from 50 adults aged 45 to 60 years, and the instruments used assessed sociodemographic and physical and emotional health variables. For data analysis, we used either the chi-square test or the Fisher's exact test. To compare the numerical variables between the two groups, the Mann-Whitney test was used, and to compare thecategoricalvariables, the Cochran test followed by the McNemar est was used. The level of significance adopted for the statistical tests was adjusted to p<0.05 and content analysis was used for qualitative data. Results: The results showed statistically significant gains in individuals in group 1, who received the QIH treatment, in the assessments for physical activity (p=0.046), anxiety score (p=0.013), emotional distress (p=0.008 and p= 0.019) and dizziness (p=0.021), when compared to group 2, controls. Conclusion: The data obtained allow us to state that QIH provides benefits for the physical and emotional health of adults. Also, its use could make people's daily lives better, reducing the cost of long and expensive treatments
Objetivo: Evaluar los beneficios de la técnica Homeostasis Quántica Informacional (HQI) sobre la salud física y emocional de personas adultas. Métodos: Estudio experimental randomizado cuali-cuantitativo con grupo control, pre y postest realizado en la ciudad de Campinas, São Paulo, Brasil. Se ha recogido los datos entre julio y septiembre de 2018 con 50 adultos en la franja de edad entre 45 y 60 años. Los instrumentos utilizados evaluaron las variables de naturaleza sociodemográfica, salud física y emocional. Se utilizó la prueba chi-cuadrado o exacto de Fisher para el análisis de los datos. Para la comparación de las variables numéricas entre los grupos se utilizó la prueba de Mann-Whitney y para la comparación de las variables categóricas se utilizó la prueba de Cochran seguida de la prueba de McNemar. El nivel de significancia adoptado para las pruebas estadísticas fue de p<0,05 y para los datos cualitativos se utilizó el análisis de contenido. Resultados: Los resultados mostraron ganancias estadísticamente significantes para los individuos del Grupo 1, que han sido tratados con la HQI, en las evaluaciones de actividad física (p=0,046), la puntuación de ansiedad (p=0,013), el sufrimiento emocional (p=0,008 e p=0,019) y de vértigo (p=0,021) comparados con el Grupo 2, el control. Conclusión: Los datos permiten afirmar que la HQI proporciona beneficios para la salud física y emocional de personas adultas, así como su utilización podría mejorar el día a día de las personas disminuyendo el coste de los tratamientos a largo plazo y costosos.
Subject(s)
Complementary Therapies , Homeostasis , Longevity , Middle AgedABSTRACT
As relações entre problemas comportamentais e dificuldades de aprendizagem ainda não estão claras na literatura. Essas variáveis representam, entretanto, importantes fatores de risco para o fracasso escolar e profissional, bem como para o desenvolvimento e a adaptação social. O objetivo desta pesquisa foi investigar as relações entre problemas comportamentais e dificuldades de aprendizagem em alunos de uma escola pública do ciclo I do ensino fundamental. Foram realizadas, também, análises dessas variáveis em função da série e do sexo dos alunos. A pesquisa seguiu um delineamento descritivo, de caráter transversal. Participaram do estudo 310 alunos do 1º ao 5º ano. Os instrumentos utilizados na coleta de dados foram o Questionário de Capacidades e Dificuldades, respondido pelos pais, e um questionário para a identificação do desempenho escolar, respondido pelas professoras. Os resultados indicam 12% de problemas comportamentais e 15% de dificuldades de aprendizagem na amostra estudada. Correlações negativas moderadas altamente significativas foram obtidas entre o desempenho escolar, as subescalas hiperatividade; problemas de conduta; e problemas de relacionamento entre pares, e o escore total do SDQ. Foram encontrados valores marginalmente significativos para a associação entre sexo e hiperatividade, indicando maior tendência de comportamentos hiperativos nos meninos. Os sintomas emocionais foram marginalmente mais frequentes nos alunos do 1º ano. Já os alunos do 2º ano apresentaram maior frequência de dificuldades de aprendizagem. Conclui-se que os dois primeiros anos do ensino fundamental podem ser considerados uma etapa crítica do percurso escolar, demandando intervenções focadas na prevenção de problemas comportamentais e de aprendizagem.(AU)
The relationships between behavioral problems and learning difficulties are still unclear in the literature. These variables represent, however, important risk factors for school and professional failures and for the development and social adaptation. This research aimed to investigate the relationships between behavioral problems and learning difficulties in the students in a public elementary school. These variables were also analyzed in relation to the school grade and gender of the students. The research followed a descriptive cross-sectional design. The sample comprised 310 students from 1st to 5th grade. The instruments used in data collection were the Strengths and Difficulties Questionnaire, answered by the parents, and a questionnaire to identify the students school performance, answered by the teachers. The results indicated 12% of behavioral problems and 15% of learning difficulties in the studied sample. Moderate highly significative negative correlations were obtained between school performance; the subscales hyperactivity, conduct problems and peer relationship problems; and the total questionnaire score . Marginally significant values were found for the association between gender and Hyperactivity, indicating a greater tendency for hyperactive behavior in boys. Emotional symptoms were marginally more frequent in 1st grade students. On the other hand, 2nd grade students had a higher frequency of learning difficulties. We concluded that the two first years of elementary school can be considered a critical phase of the school trajectory and it needs preventive interventions focused on behavioral and learning problems.(AU)
Las relaciones entre los problemas de conducta y las dificultades de aprendizaje aún no están claras en la literatura. Estas variables representan, sin embargo, importantes factores de riesgo para el fracaso escolar y profesional, así como para el desarrollo y la adaptación social. El objetivo de este estudio fue investigar las relaciones entre los problemas de conducta y las dificultades de aprendizaje en estudiantes de una escuela primaria pública. También se realizaron análisis de estas variables en función del grado y sexo de los alumnos. La investigación siguió un diseño descriptivo y transversal. Participaron del estudio 310 estudiantes de 1º a 5º grado. Los instrumentos utilizados fueron el Cuestionario de Habilidades y Dificultades, respondido por los padres, y un cuestionario para identificar el desempeño escolar, respondido por los docentes. Los resultados indican un 12% de problemas de conducta y un 15% de dificultades de aprendizaje en la muestra estudiada. Se obtuvieron correlaciones negativas altamente significativas entre el rendimiento escolar y la puntuación total y de las subescalas hiperactividad problemas de conducta y problemas de relación con los compañeros del cuestionario. Se encontró aún mayor tendencia a la conducta hiperactiva en los niños. Los "síntomas emocionales" fueron ligeramente más frecuentes en los estudiantes de primer año, mientras los estudiantes de segundo año tenían una mayor frecuencia de dificultades de aprendizaje. Se concluye que los dos primeros años de la escuela primaria pueden ser una fase crítica de la trayectoria escolar, lo que requiere intervenciones enfocadas en la prevención de problemas de conducta y aprendizaje.(AU)
Subject(s)
Humans , Male , Female , Child , Child Behavior , Demography , Education, Primary and Secondary , Problem Behavior , Learning Disabilities , Anxiety , Parents , Psychology , Public Policy , Research , Attention , Attention Deficit Disorder with Hyperactivity , Schools , Self Concept , Signs and Symptoms , Social Adjustment , Social Isolation , Students , Teaching , Behavior , School Feeding , Bipolar Disorder , Neurosciences , Family , Child , Data Collection , Risk Factors , Biological Science Disciplines , Substance-Related Disorders , Self Efficacy , Creativity , Affective Symptoms , Agraphia , Growth and Development , Dyslexia , Educational Status , Disease Prevention , Faculty , Altruism , Dyscalculia , Medicalization , Literacy , Academic Failure , Diversity, Equity, Inclusion , Handwriting , Homeostasis , Hyperkinesis , Intelligence Tests , Interpersonal Relations , Learning , Literature , Intellectual Disability , Methylphenidate , MotivationABSTRACT
The eosinophil is a cell of the immune system, with an arsenal of substances that can alter the balance that exists in the different organs where they are found. With the advent of monoclonal antibodies, concern about their depletion has become an important turning point in their formulation. For this reason, it is of vital importance to investigate the consequences of the mechanism of action of biological agents, in the short and long term. This review tries to show the role of eosinophils in both homeostasis and disease, and their relationship and interaction with monoclonal drugs in diseases focused on the Th2 profile. It is expected that this article can be useful when making the decision to start treatment with monoclonals, specifically anti-interleukin-5 or against its receptor
Subject(s)
Eosinophils , Pharmaceutical Preparations , Biological Factors , Lymphocyte Depletion , Adrenal Cortex Hormones , HomeostasisABSTRACT
La población mayor de 60 años es el grupo etario de mayor crecimiento en el mundo. Debido a que la depresión es una patología frecuente en la persona adulta mayor y anciana, los inhibidores de la recap- tación de la serotonina (ISRS) son el tratamiento de primera línea de elección. Este trabajo referencia la asociación del consumo de estos fármacos con la disminución de la densidad ósea mineral (DMO), el riesgo de fracturas y su repercusión en la atención odontológica. Además, incluye una breve descripción de la homeostasis ósea y la relación depresión-carga alostática. El trabajo interdisciplinario y una correcta anamnesis pueden detectar posibles complicaciones y riesgos vinculados con este tipo de medicamen- tos. Ello facilitaría un mejor manejo, más aún en el adulto mayor, donde una pequeña variable puede repercutir en su integridad (AU)
The population over 60 is the fastest growing age group in the world. Depression is a frequent pathology in the elderly and the elderly, with serotonin reuptake inhibitors (SSRI) being the 1st line treatment of choice. The association of the consumption of this drug with a decrease in bone mineral density (BMD), risk of fractures and its impact on dental care are referenced in this work. In addition, it includes a brief description of bone homeostasis and the depression-allostatic load relationship. Interdisciplinary work and a correct anamnesis can detect possible complications and risks linked to this type of medication, facilitating better management and even more so in the elderly, where a small variable can affect their integrity (AU)
Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Dental Care for Aged/methods , Selective Serotonin Reuptake Inhibitors/adverse effects , Depression/complications , Antidepressive Agents/adverse effects , Bone Density/drug effects , Dental Implants/adverse effects , Risk Factors , Age Factors , Bone Remodeling/physiology , Selective Serotonin Reuptake Inhibitors/therapeutic use , Dental Restoration Failure , Fractures, Bone/prevention & control , Allostasis , HomeostasisABSTRACT
Abstract Fluoride anions are indispensable trace elements required for sustaining life. To investigate the homeostasis and action of fluoride in the body, a new highly sensitive and selective fluorescence detection method was designed for fluoride in aqueous solutions. A fluorescent probe for fluoride (FP-F) was synthesized for imaging F- in living cells. The design strategy for the probe was based on the specific reaction between fluoride and silica to mediate deprotection of this probe to fluorescein. Upon treatment with F-, FP-F, a closed and weakly fluorescent lactone, was transformed into an open and strongly fluorescent product. Under the optimum conditions, the detection limit for fluoride was 0.526 nM. FP-F could detect micromolar changes in F- concentrations in living cells by confocal microscopy.
Subject(s)
Fluorescein/pharmacology , Fluorescence , Fluorine/analysis , Trace Elements/adverse effects , Cells/metabolism , Microscopy, Confocal/methods , Diagnosis , Fluorescent Dyes/pharmacology , Homeostasis , MethodsABSTRACT
RESUMO Objetivo estimular a reflexão acerca da assistência de enfermagem ao paciente com sepse a partir dos quatro princípios de conservação propostos pelo modelo conceitual de Myra Levine. Método estudo teórico-reflexivo sobre a relação existente entre os princípios de conservação de Levine e o paciente com sepse. Resultados vigilância aos princípios da conservação da energia observando oferta do oxigênio, idade dos pacientes e os parâmetros energéticos (sinais vitais); da integridade estrutural ao reconhecer precocemente às disfunções orgânicas no pacote hora-1; da integridade pessoal ao preservar a identidade do cliente com dificuldade de verbalizar ou outra condição e da integridade social ao relacionar-se com o paciente e família incluindo-os no processo de cuidado. Conclusão e implicações para a prática os princípios de conservação do modelo proposto apresentam relação com a assistência realizada pela equipe de enfermagem na manutenção do equilíbrio físico, pessoal e social do paciente com sepse. Espera-se que os enfermeiros articulem o conhecimento científico geral da assistência ao paciente com sepse ao seu conhecimento específico, por meio de um referencial teórico, para a promoção da adaptação, conservação e integridade do indivíduo.
RESUMEN Objetivo estimular la reflexión acerca de la atención de enfermería al paciente con sepsis a partir de los cuatro principios de conservación propuestos por el modelo conceptual de Myra Levine. Método estudio teórico-reflexivo sobre la relación entre los principios de conservación de Levine y el paciente con sepsis. Resultados vigilancia de los principios de conservación de la energía, observando el aporte de oxígeno, la edad de los pacientes y los parámetros energéticos (signos vitales); de la integridad estructural mediante el reconocimiento temprano de las disfunciones orgánicas en el paquete hora-1; de la integridad personal al preservar la identidad del cliente con dificultad para verbalizar u otra condición e de la integridad social al relacionarse con el paciente y su familia, incluyéndolos en el proceso de cuidado. Conclusión e implicaciones para la práctica los principios de conservación del modelo propuesto se relacionan con la atención brindada por el equipo de enfermería en el mantenimiento del equilibrio físico, personal y social del paciente con sepsis. Se espera que los enfermeros articulen el conocimiento científico general del cuidado del paciente con sepsis con sus conocimientos específicos, a través de un referencial teórico, para promover la adaptación, conservación e integridad del individuo.
ABSTRACT Objective encourage reflection on nursing care for patients with sepsis based on the four conservation principles proposed by Myra Levine's conceptual model. Method theoretical-reflective study on the relationship between Levine's conservation principles and the patient with sepsis. Results attentiveness to the principles of energy conservation, observing oxygen supply, patients' age and energy parameters (vital signs); of structural integrity by early recognition of organic dysfunctions in the hour-1 bundle; of personal integrity when preserving the identity of the client with difficulty to verbalize or another condition and social integrity when relating to the patient and family, including them in the care process. Conclusion and implications for practice the conservation principles of the proposed model are presented in relation to assistance provided by the nursing team in maintaining the physical, personal and social balance of the patients with sepsis. Nurses are expected to articulate the general scientific knowledge of sepsis patient care with their specific knowledge, through a theoretical framework, to promote the individual's adaptation, conservation and integrity.
Subject(s)
Humans , Nursing Theory , Sepsis/nursing , Nursing Care , Homeostasis , Nursing, TeamABSTRACT
Numerosos reportes demuestran la presencia de biomarcadores de estreÌs oxidativo en la saliva de fumadores y hay un creciente intereÌs en correlacionar estos procesos moleculares con la etiología de algunas enfermedades orales, como la periodontitis, una enfermedad inmunoinflamatoria croÌnica relacionada con un desequilibrio de la homeostasis redox celular. Objetivo: realizar una revisioÌn narrativa sobre la relacioÌn entre la disminucioÌn de la capacidad antioxidante salival inducida por humo de tabaco, la periodontitis y el potencial uso de farmacología redox para el tratamiento de esta patología. Métodos: se realizoÌ una buÌsqueda bibliograÌfica en bases de datos como PUBMED (NLM, NIH, NCBI) y SciELO. Resultados: existe evidencia que relaciona la baja capacidad antioxidante salival con un retraso en el restablecimiento de las condiciones normales en la cavidad oral ante el desarrollo de periodontitis. A su vez, el estado inflamatorio asociado colabora sineÌrgicamente, provocando un mayor danÌo tisular con peÌrdida de tejidos de soporte dentario, fenoÌmeno que podría ser modulado por la accioÌn de farmacología redox. Conclusiones: la intervencioÌn con farmacología redox, podría atenuar los biomarcadores de progresioÌn de la enfermedad periodontal, constituyendo una herramienta prometedora para utilizar en conjunto con las estrategias de tratamiento tradicionales.
Numerous reports demonstrate the presence of oxidative stress biomarkers in the saliva of smokers and there is a growing interest in correlating these molecular processes with the etiology of some oral diseases, such as periodontitis, a chronic immunoinlammatory disease related to an imbalance of cellular redox homeostasis. Aims: achieve a narrative review on the relationship between the decrease in salivary antioxidant capacity induced by tobacco smoke, periodontitis, and the potential use of redox pharmacology for the treatment of this pathology. Methods: a bibliographic search was carried out in databases such as PUBMED (NLM, NIH, NCBI) and SciELO. Results: there is evidence that relates the low salivary antioxidant capacity with a delay in the reestablishment of normal conditions in the oral cavity before the development of periodontitis. In turn, the associated inflammatory state collaborates synergistically, causing greater tissue damage with loss of dental support tissues, a phenomenon that could be modulated by the action of redox pharmacology. Conclusions: intervention with redox pharmacology could attenuate the biomarkers of periodontal disease progression, constituting a promising tool to be used in conjunction with traditional treatment strategies.
Muitos artigos demonstram a presença de biomarcadores de estresse oxidativo na saliva de fumantes e haÌ um interesse crescente em correlacionar esses processos moleculares com a etiologia de algumas doenças bucais, como a periodontite, uma doença imunoinlamatoÌria croÌnica relacionada a um desequiliÌbrio da redox celular homeostase. Objetivo: realizar uma revisaÌo narrativa sobre a relaçaÌ o entre a diminuiçaÌ o da capacidade antioxidante salivar induzida pela fumaça do tabaco, periodontite e o uso potencial da farmacologia redox para o tratamento desta patologia. Métodos: uma pesquisa bibliográica foi realizada usando bases de dados como PUBMED (NLM, NIH, NCBI) e SciELO. Resultados: haÌ evideÌncias que relacionam a baixa capacidade antioxidante salivar com o retardo no restabelecimento das condiçoÌes normais da cavidade oral antes do desenvolvimento da periodontite. Por sua vez, o estado inflamatório associado colabora sinergicamente, causando maior dano tecidual com perda de tecidos de suporte dentário, fenoÌmeno que poderia ser modulado pela açaÌ o da farmacologia redox. Conclusões: a intervençaÌ o com a farmacologia redox poderia atenuar os biomarcadores de progressaÌ o da doença periodontal, constituindo-se em uma ferramenta promissora para ser utilizada em conjunto com estrateÌgias tradicionais de tratamento.
Subject(s)
Humans , Periodontitis/etiology , Periodontitis/drug therapy , Saliva/metabolism , Oxidative Stress , Tobacco Smoking/adverse effects , Antioxidants/therapeutic use , Oxidation-Reduction , Biomarkers , Oxidative Stress/drug effects , HomeostasisABSTRACT
The nervous system and the immune system are relatively independent but interactional, and neuro-immune regulation is very important for the respiratory system to resist external harmful stimuli and to maintain homeostasis. Neuro-immune interaction is involved in the occurrence and development of respiratory diseases, and is essential for monitoring and modulating inflammation and tissue repair. This article summaries the neuro-immune regulation of respiratory system and discusses its role in respiratory diseases, aiming to provide a theoretical basis for further understanding the crosstalk between the nervous and immune systems, to explore the underlying mechanism in respiratory diseases, and to provide new thoughts for the prevention and treatment of respiratory diseases.
Subject(s)
Humans , Homeostasis , Immune System , Inflammation , Nervous System , Neuroimmunomodulation , Respiration DisordersABSTRACT
This research was carried out aiming at evaluating the effects of nitrate and ammonium ions on nutrient accumulation, biochemical components and yield of Italian zucchini (cv. Caserta) grown in a hydroponic system under salt stress conditions. The experiment was carried out in a greenhouse utilizing an experimental design in randomized blocks, arranged in a 2 x 5 factorial scheme, with 4 replications. The treatments consisted of two forms of nitrogen (nitrate - NO3 - and ammonium - NH4 + ) and 5 electrical conductivity levels of irrigation water (ECw) (0.5, 2.0, 3.5, 5.0 and 6.5 dS m-1). The analysis of the results indicated that supply of N exclusively in NH4 + form promotes greater damage to the leaf membrane and reduction in accumulation of macronutrients and higher Na+ /K+ , Na+ /Ca++ and Na+ /Mg++ ratios in the shoots of zucchini plants. Electrical conductivity of irrigation water above 2.0 dS m-1 reduces the accumulation of nutrients in shoot and yield of Italian zucchini plant. The toxicity of NH4 + under Italian zucchini plants overlap the toxicity of the salinity, since its fertilization exclusively with this form of nitrogen inhibits its production, being the NO3 - form the most suitable for the cultivation of the species.
Este trabalho foi desenvolvido com o objetivo de avaliar os efeitos dos íons nitrato e amônio sobre o acúmulo de nutrientes e produção da abobrinha italiana (cv. Caserta) cultivada em sistema hidropônico sob estrese salino. O experimento foi conduzido em casa de vegetação utilizando o delineamento experimental em blocos casualizados, arranjados em esquema fatorial 2 x 5, com 4 repetições. Os tratamentos foram constituídos de duas formas de nitrogênio (nitrato - NO3 - e amônio - NH4 + ) e cinco níveis de condutividade elétrica da água de irrigação (CEa ) (0,5; 2,0; 3,5; 5,0 e 6,5 dS m-1). As análises dos resultados indicaram que suprimento de N exclusivamente em forma de NH4 + promove maiores danos na membrana foliar e redução no acúmulo de macronutrientes e maiores relações Na+ /K+ , Na+ /Ca++ e Na+ /Mg++ na parte aérea das plantas de abobrinha. A irrigação com água a cima de 2,0 dS m-1 reduz o acúmulo de nutrientes na parte aérea das plantas e a produção de abobrinha. A toxicidade do NH4 + sob abobrinha italiana sobrepõe-se à toxicidade da salinidade, pois a fertilização exclusiva com esta forma de nitrogênio inibe sua produção, sendo a forma NO3 - a mais adequada para o cultivo da espécie.
Subject(s)
Ammonium Compounds , Nitrogen , Plant Roots/chemistry , Salt Stress , Homeostasis , Italy , NitratesABSTRACT
Zn2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial dynamics, apoptosis and mitophagy. However, it is not understood how the proper mitochondrial Zn2+ level is achieved to maintain mitochondrial homeostasis. Using Caenorhabditis elegans, we reveal here that a pair of mitochondrion-localized transporters controls the mitochondrial level of Zn2+. We demonstrate that SLC-30A9/ZnT9 is a mitochondrial Zn2+ exporter. Loss of SLC-30A9 leads to mitochondrial Zn2+ accumulation, which damages mitochondria, impairs animal development and shortens the life span. We further identify SLC-25A25/SCaMC-2 as an important regulator of mitochondrial Zn2+ import. Loss of SLC-25A25 suppresses the abnormal mitochondrial Zn2+ accumulation and defective mitochondrial structure and functions caused by loss of SLC-30A9. Moreover, we reveal that the endoplasmic reticulum contains the Zn2+ pool from which mitochondrial Zn2+ is imported. These findings establish the molecular basis for controlling the correct mitochondrial Zn2+ levels for normal mitochondrial structure and functions.
Subject(s)
Animals , Caenorhabditis elegans/metabolism , Cation Transport Proteins/genetics , Homeostasis , Mitochondria/metabolism , Zinc/metabolismABSTRACT
The dorsal lingual epithelium, which is composed of taste buds and keratinocytes differentiated from K14+ basal cells, discriminates taste compounds and maintains the epithelial barrier. N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotic cells. How METTL3-mediated m6A modification regulates K14+ basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear. Here we show knockout of Mettl3 in K14+ cells reduced the taste buds and enhanced keratinocytes. Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds. Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization, but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery. Mechanically, we revealed that the most frequent m6A modifications were enriched in Hippo and Wnt signaling, and specific peaks were observed near the stop codons of Lats1 and FZD7. Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.
Subject(s)
Animals , Mice , Epithelium/metabolism , Homeostasis , Methylation , Methyltransferases/metabolism , RNA , Taste Buds/metabolismABSTRACT
Head and neck squamous cell carcinoma (HNSCC) still lacks effective targeted treatment. Therefore, exploring novel and robust molecular targets is critical for improving the clinical outcome of HNSCC. Here, we reported that the expression levels of family with sequence similarity 64, member A (FAM64A) were significantly higher in HNSCC tissues and cell lines. In addition, FAM64A overexpression was found to be strongly associated with an unfavorable prognosis of HNSCC. Both in vitro and in vivo evidence showed that FAM64A depletion suppressed the malignant activities of HNSCC cells, and vice versa. Moreover, we found that the FAM64A level was progressively increased from normal to dysplastic to cancerous tissues in a carcinogenic 4-nitroquinoline-1-oxide mouse model. Mechanistically, a physical interaction was found between FAM64A and forkhead box protein M1 (FOXM1) in HNSCC cells. FAM64A promoted HNSCC tumorigenesis not only by enhancing the transcriptional activity of FOXM1, but also, more importantly, by modulating FOXM1 expression via the autoregulation loop. Furthermore, a positive correlation between FAM64A and FOXM1 was found in multiple independent cohorts. Taken together, our findings reveal a previously unknown mechanism behind the activation of FOXM1 in HNSCC, and FAM64A might be a promising molecular therapeutic target for treating HNSCC.
Subject(s)
Animals , Mice , Carcinogenesis , Cell Line, Tumor , Cell Proliferation , Cell Transformation, Neoplastic , Head and Neck Neoplasms/genetics , Homeostasis , Squamous Cell Carcinoma of Head and NeckABSTRACT
Difference of chronotypes makes influence to cognitive performance of individuals in routine duties. In this paper, 55 subjects with different chronotypes were subjected to continuous sleep deprivation for 30 h by using the constant routine protocol, during which core body temperature was measured continuously, and subjective sleepiness self-rating and the performance of selective attention were measured hourly. The results showed that the phase difference of core body temperature has no significant difference, yet the amplitude and term difference among the three chronotypes are significant. There was an advance in phase between subjective sleepiness self-rating and core body temperature, and the self-rating sleepiness of evening type came the latest, and the self-rating sleepiness of morning type dissipated the fastest. The response time of selective attention showed a 2 h phase delay with subjective sleepiness self-rating. And the analysis of core body temperature showed that the later the chronotype was, the greater the phase delay was. The correct rate of selective attention of different chronotypes were inconsistent with delay of subjective sleepiness self-rating and core body temperature. We provide reference for industry, aviation, military, medical and other fields to make a more scientific scheduling/ shifting based on cognitive performance characteristics of different chronotypes.