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1.
Psicol. ciênc. prof ; 43: e254081, 2023. graf
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1440799

ABSTRACT

Este artigo pretende conhecer como a rede de cuidados em saúde tem se operacionalizado a partir da percepção de familiares de crianças com demanda de cuidado em saúde mental (SM). Foram realizados dois grupos focais, um com familiares da Atenção Básica (AB) e outro com familiares do Centro de Atenção Psicossocial Infantojuvenil (CAPSij), totalizando 15 participantes. Seguiu-se com a análise lexical do tipo classificação hierárquica descendente, com o auxílio do software R Interface, a fim de análises multidimensionais de textos e questionários (IRaMuTeQ), resultando em cinco classes: A Pílula Mágica; Forças e Fraquezas dos serviços; Procurando por ajuda; Aceitando o diagnóstico da criança e Onde procurei ajuda. Os resultados apontam para dificuldades presentes na AB em identificar e manejar situações de Saúde Mental Infantojuvenil (SMIJ), por meio de uma lógica ainda medicalizante. Ressalta-se que a escola é apresentada como lugar de destaque na produção da demanda por cuidado e a família ainda é pouco convocada à construção das ações. Conclui-se, então, que avanços ainda são necessários para operacionalização de um cuidado pautado nas diretrizes da política de SMIJ.(AU)


This article aims to know how the healthcare network has been operationalized from the perception of family members of children with demand for mental health care (MH). Two focus groups were held, one with family members from Primary Care (PC) and the other with family members from the Child Psychosocial Care Center (CAPSij), totaling 15 participants. A lexical analysis of the descending hierarchical classification type was performed with the help of the software R Interface for multidimensional analyzes of texts and questionnaires (IRAMUTEQ), resulting in five classes: The Magic Pill; Strengths and Weaknesses of services; Looking for help; Accepting the child's diagnosis; and Where did I look for help. The results point to difficulties present in PC in identifying and managing situations of mental health in children and adolescents (MHCA), with a medicalization logic. Note that the school is presented as a prominent place in producing the demand for care, and the family is still not very much involved in the actions. It is, thus, concluded that advances are still needed for operationalization of care guided by MHCA policy guidelines.(AU)


Este artículo tuvo por objetivo conocer cómo opera una red asistencial a partir de la percepción de familiares de niños con demanda de atención en salud mental (SM). Se realizaron dos grupos focales, uno con familiares de Atención Primaria (AP) y otro con familiares del Centro de Atención Psicosocial Infantojuvenil (CAPSij), totalizando 15 participantes. Se realizó análisis léxico del tipo clasificación jerárquica descendente con la ayuda del software Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires (IRAMUTEQ), lo que resultó en cinco clases: "La píldora mágica"; "Fortalezas y debilidades de los servicios"; "En busca de ayuda"; "Aceptar el diagnóstico del niño" y "¿Dónde busqué ayuda?". Los resultados apuntan las dificultades presentes en AP para identificar y manejar situaciones de salud mental infantojuvenil (SMIJ) mediante una lógica aún medicalizante. La escuela tiene un lugar destacado en la producción de la demanda de cuidados y la familia aún no está muy involucrada en la construcción de acciones. Se concluye que se necesitan avances para ofertar una atención guiada por lineamientos de la política del SMIJ.(AU)


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adult , Middle Aged , Young Adult , Child , Adolescent , Intersectoral Collaboration , Mental Health Assistance , Health Policy , Anxiety Disorders , Parents , Patient Escort Service , Pediatrics , Play and Playthings , Play Therapy , Prejudice , Professional-Family Relations , Professional-Patient Relations , Proprioception , Psychoanalysis , Psychology , Psychomotor Disorders , Psychotherapy , Psychotic Disorders , Referral and Consultation , Attention Deficit Disorder with Hyperactivity , Self Care , Autistic Disorder , Social Alienation , Social Environment , Social Isolation , Social Support , Socialization , Pathological Conditions, Signs and Symptoms , Therapeutics , Violence , Mainstreaming, Education , Shyness , Neurosciences , Adaptation, Psychological , Patient Acceptance of Health Care , Health Centers , Cognitive Behavioral Therapy , Comorbidity , Child Advocacy , Child Behavior Disorders , Child Care , Child Development , Developmental Disabilities , Child Language , Occupational Therapy , Cognition , Communication Disorders , Neurobehavioral Manifestations , Stereotypic Movement Disorder , Behavioral Disciplines and Activities , Disabled Children , Affect , Crying , Aggression , Dermatitis, Contact , Diagnosis , Dissociative Disorders , Dyslexia , Echolalia , Education , Education of Intellectually Disabled , Education, Special , Emotions , Family Conflict , Speech, Language and Hearing Sciences , Medication Adherence , Apathy , Acceptance and Commitment Therapy , Emotional Adjustment , Literacy , Neurodevelopmental Disorders , Autism Spectrum Disorder , Orientation, Spatial , Applied Behavior Analysis , Cognitive Remediation , Emotion-Focused Therapy , Pediatricians , Data Analysis , Sadness , Psychological Distress , Social Interaction , Health Services Accessibility , Human Rights , Hyperkinesis , Intelligence , Interpersonal Relations , Anger , Language Disorders , Learning , Learning Disabilities , Loneliness , Malpractice , Mental Disorders , Intellectual Disability , Nervous System Diseases , Obsessive-Compulsive Disorder
2.
Psicol. ciênc. prof ; 42: e236353, 2022.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1406396

ABSTRACT

O consumo de medicamentos estimulantes cresceu nos últimos anos, no Brasil e no mundo. Pessoas de diferentes idades, especialmente crianças e adolescentes, passaram a consumir estimulantes como a principal terapêutica utilizada para tratar o transtorno do déficit de atenção e hiperatividade (TDAH). Nesse contexto, estimulantes como as anfetaminas e o metilfenidato, mais conhecidos pelos nomes comerciais de Adderall e Ritalina, ganharam visibilidade social em razão da associação desses psicofármacos ao aperfeiçoamento de funções psíquicas como a atenção e o aumento na qualidade e no tempo de rendimento dos sujeitos nas mais variadas atividades. Com isso, aumentou também a procura desses estimulantes por pessoas que não estão em tratamento médico, mas que buscam aprimorar seu desempenho nas atividades que realizam. Diante desse cenário, o objetivo deste artigo foi demonstrar como o crescimento no consumo de estimulantes, seja por sujeitos em tratamento médico ou não, está relacionado aos processos de socialização hegemônicos nas sociedades capitalistas atualmente. Articulando o contexto apresentado com os conceitos da psicanálise lacaniana, foi possível concluir que o consumo massivo de estimulantes está relacionado aos processos de patologização e medicalização da existência, colocados em movimento por uma articulação entre o discurso médico-científico e o discurso do capitalista na contemporaneidade.(AU)


The consumption of stimulating drugs has grown in recent years in Brazil and worldwide. People of all ages, especially children and adolescents, started to use stimulants as the main therapy used to treat attention deficit hyperactivity disorder (ADHD). In this context, stimulants such as amphetamines and methylphenidate, better known by the trade names Adderall and Ritalin, have gained social visibility due to the association of these psychoactive drugs with the improvement of psychic functions such as attention and the increase in quality and performance time of subjects in the most varied activities. As a result, the demand for these stimulants has also increased by people who are not undergoing medical treatment, but who seek to improve their performance in the activities they perform. Given this scenario, this article aimed to demonstrate how the growth in the consumption of stimulants, whether by subjects undergoing medical treatment or not, is related to the hegemonic socialization processes in capitalist societies today. Articulating the context presented with the concepts of Lacanian psychoanalysis, it was possible to conclude that the massive consumption of stimulants is related to the processes of pathologization and medicalization of existence, set in motion by an articulation between the medical-scientific discourse and the capitalist discourse in contemporary times.(AU)


El consumo de drogas estimulantes ha crecido en los últimos años, en Brasil y en otros países. Diversas personas, especialmente niños y adolescentes, comenzaron a usar estimulantes como la terapia principal utilizada para tratar el trastorno por déficit de atención con hiperactividad (TDAH). En este contexto, los estimulantes como las anfetaminas y el metilfenidato, mejor conocidos por los nombres comerciales Adderall y Ritalina, han ganado visibilidad social debido a la asociación de estas drogas psicoactivas a la mejora de las funciones psíquicas, como la atención y el aumento de la calidad y el tiempo de rendimiento de los pacientes en diversas actividades. Como resultado, la demanda de estos estimulantes también ha aumentado por las personas que no reciben tratamiento médico, pero que buscan mejorar su desempeño en las actividades que realizan. Dado este escenario, el objetivo de este artículo era demostrar cómo el crecimiento en el consumo de estimulantes, ya sea por sujetos que reciben tratamiento médico o no, está relacionado con los procesos de socialización hegemónica en la sociedad capitalista actual. De la articulación del contexto presentado con los conceptos del psicoanálisis lacaniano se concluye que el consumo masivo de estimulantes está relacionado con los procesos de patologización y medicalización de la existencia, puestos en marcha por una articulación entre el discurso médico-científico y el discurso capitalista en los tiempos contemporáneos.(AU)


Subject(s)
Humans , Male , Female , Child , Adolescent , Pathology , Psychoanalysis , Psychotropic Drugs , Attention Deficit Disorder with Hyperactivity , Medicalization , Central Nervous System Stimulants , Psychology , Socialization , Therapeutics , Mainstreaming, Education , Pharmaceutical Preparations , Child , Adolescent , Panic Disorder , Adolescent Psychiatry , Substance-Related Disorders , Capitalism , Depression , Growth and Development , Diagnosis , Education, Special , Brazilian Health Surveillance Agency , Psychological Distress , Amphetamines , Hyperkinesis , Memory , Mental Disorders , Methylphenidate , Neuropsychological Tests
3.
Neuroscience Bulletin ; (6): 1658-1670, 2021.
Article in English | WPRIM | ID: wpr-922653

ABSTRACT

Mechanistic target of rapamycin (mTOR) signaling governs important physiological and pathological processes key to cellular life. Loss of mTOR negative regulators and subsequent over-activation of mTOR signaling are major causes underlying epileptic encephalopathy. Our previous studies showed that UBTOR/KIAA1024/MINAR1 acts as a negative regulator of mTOR signaling, but whether UBTOR plays a role in neurological diseases remains largely unknown. We therefore examined a zebrafish model and found that ubtor disruption caused increased spontaneous embryonic movement and neuronal activity in spinal interneurons, as well as the expected hyperactivation of mTOR signaling in early zebrafish embryos. In addition, mutant ubtor larvae showed increased sensitivity to the convulsant pentylenetetrazol, and both the motor activity and the neuronal activity were up-regulated. These phenotypic abnormalities in zebrafish embryos and larvae were rescued by treatment with the mTORC1 inhibitor rapamycin. Taken together, our findings show that ubtor regulates motor hyperactivity and epilepsy-like behaviors by elevating neuronal activity and activating mTOR signaling.


Subject(s)
Animals , Hyperkinesis/genetics , Mutation/genetics , Signal Transduction , TOR Serine-Threonine Kinases/metabolism , Zebrafish/metabolism
4.
Article in English | WPRIM | ID: wpr-765843

ABSTRACT

Abnormal eye movements are commonly observed in movement disorders. Ocular motility examination should include bedside evaluation and laboratory recording of ocular misalignment, involuntary eye movements, including nystagmus and saccadic intrusions/oscillations, triggered nystagmus, saccades, smooth pursuit (SP), and the vestibulo-ocular reflex. Patients with Parkinson's disease (PD) mostly show hypometric saccades, especially for the self-paced saccades, and impaired SP. Early vertical saccadic palsy is characteristic of progressive supranuclear palsy-Richardson's syndrome. Patients with cortico-basal syndrome typically show a delayed onset of saccades. Downbeat and gaze-evoked nystagmus and hypermetric saccades are characteristic ocular motor findings in ataxic disorders due to cerebellar dysfunction. In this review, we discuss various ocular motor findings in movement disorders, including PD and related disorders, ataxic syndromes, and hyperkinetic movement disorders. Systemic evaluation of the ocular motor functions may provide valuable information for early detection and monitoring of movement disorders, despite an overlap in the abnormal eye movements among different movement disorders.


Subject(s)
Humans , Ataxia , Cerebellar Diseases , Eye Movements , Hyperkinesis , Movement Disorders , Paralysis , Parkinson Disease , Parkinsonian Disorders , Pursuit, Smooth , Reflex, Vestibulo-Ocular , Saccades
5.
Article in English | WPRIM | ID: wpr-764168

ABSTRACT

Hyperglycemia-induced hemichorea (HGHC) is a rare but characteristic hyperkinetic movement disorder involving limbs on one side of the body. In a 75-year-old woman with a left-sided HGHC, conventional brain MR imaging showed very subtle T1-hyperintensity and unique gadolinium enhancement in the basal ganglia contralateral to movements. Multi-parametric MRI was acquired using pulse sequence with quantification of relaxation times and proton density by multi-echo acquisition. Myelin map was reconstructed based on new tissue classification modeling. In this case report of multi-parametric MRI, quantitative measurement of myelin change related to HGHC in brain structures and its possible explanations are presented. This is the first study to demonstrate myelin loss related to hyperglycemic insult in multi-parametric quantitative MR imaging.


Subject(s)
Aged , Female , Humans , Basal Ganglia , Brain , Classification , Extremities , Gadolinium , Hyperglycemia , Hyperkinesis , Magnetic Resonance Imaging , Movement Disorders , Myelin Sheath , Protons , Relaxation
6.
Psicol. teor. prát ; 19(1): 44-54, abr. 2017.
Article in Portuguese | LILACS | ID: biblio-895880

ABSTRACT

Este escrito discute os efeitos da escuta de pais nas Entrevistas Preliminares da criança para o início do tratamento. Foram analisadas as entrevistas realizadas com uma mãe que pede atendimento psicológico para seu filho por queixa de hiperatividade. Parte-se do pressuposto de que, algumas vezes, o sintoma apresentado pela criança revela aspectos mal elaborados do processo de recalcamento da história infantil dos pais. Pensamos que o trabalho com quem demanda atendimento para a criança permite recompor o que de seu infantil ficou fraturado, e, a partir de uma operação de elaboração permitida pela rememoração, este possibilita que os pais autorizem a criança a demandar tratamento em nome próprio. Consideramos as Entrevistas Preliminares realizadas com os pais um dispositivo potente que permite o reposicionamento das funções parentais frente à demanda de atendimento para o filho.


This writing discusses the effects of parents listening to the Preliminary Interviews of a child at the start of treatment. Interviews with a mother who asked psychological care for her child because of complaints about hyperactivity were analyzed. We start from the hypothesis that sometimes symptoms presented by the child reveal badly elaborated aspects of the repression process of the parents' childhood. We think that working with those who ask for care for the child lets us recover what was fractured in the child's childhood and, from a development operation permitted by the child's memories, enables parents to allow the child to require treatment on their own. We consider the Preliminary Interviews with parents a powerful device that allows repositioning of parental roles in order to fulfill the demand of care for the child.


Este trabajo pretende discutir los efectos de la escucha de padres en Entrevistas Preliminares del niño para el inicio de su tratamiento. Para esto se analizaron las entrevistas que fueron realizadas con una madre que pidió atención psicológica para su hijo por una queja de hiperactividad. Partimos de la presuposición que muchas veces el síntoma presentado por el niño manifiesta aspectos mal elaborados del proceso de represión de la historia infantil de los padres. Pensamos que el trabajo con quien demanda atención psicológica para el niño permite recomponer, por una elaboración permitida por la rememoración, lo que quedó fracturado de su propio infantil. Esto permitiría que los padres autoricen que el niño demande tratamiento por su propio nombre. Consideramos las Entrevistas Preliminares con los padres un dispositivo potente pues permite un cambio de la posición ocupada por ellos en relación a la demanda del niño.


Subject(s)
Humans , Child , Child , Hyperkinesis , Interview, Psychological
7.
Hist. ciênc. saúde-Manguinhos ; 22(3): 761-779, jul.-set. 2015.
Article in Spanish | LILACS | ID: lil-756446

ABSTRACT

El artículo describe y analiza las facetas conductual y neurológica que congregan los debates sobre el trastorno por déficit de atención e hiperactividad y marca algunos antecedentes conceptuales históricos. En la dimensión conductual predominan enunciados descriptivos, centrados en las conductas de aquellos diagnosticados. En la dimensión neurológica se incluyen explicaciones etiológicas, mayormente sobre el funcionamiento cerebral. El análisis se fundamentó en materiales documentales como estudios históricos; entrevistas a profesionales de la salud de Ciudad de Buenos Aires, realizadas entre 2008 y 2011; publicaciones especializadas; instrumentos psicométricos; y manuales psiquiátricos.


The article describes and analyzes the behavioral and neurological aspects that bring together discussions on attention deficit disorder and hyperactivity and outlines some historical conceptual antecedents. Descriptive statements focusing on the behavior of those diagnosed predominate in the behavioral dimension. Etiological explanations, principally on brain function in the neurological dimension are included. The analysis was based on documentary materials such as historical studies, interviews with health professionals in Buenos Aires between 2008 and 2011, specialized publications, psychometric instruments and psychiatric manuals.


Subject(s)
Humans , Child , History, 18th Century , History, 20th Century , History, 21st Century , Attention Deficit Disorder with Hyperactivity/history , Argentina , Diagnostic and Statistical Manual of Mental Disorders , Hyperkinesis/history
8.
Braz. j. med. biol. res ; 48(2): 96-107, 02/2015. tab, graf
Article in English | LILACS | ID: lil-735857

ABSTRACT

Crohn's disease (CD) and ulcerative colitis (UC) are intestinal disorders that comprise the inflammatory bowel diseases (IBD). These disorders have a significant effect on the quality of life of affected patients and the increasing number of IBD cases worldwide is a growing concern. Because of the overall burden of IBD and its multifactorial etiology, efforts have been made to improve the medical management of these inflammatory conditions. The classical therapeutic strategies aim to control the exacerbated host immune response with aminosalicylates, antibiotics, corticosteroids, thiopurines, methotrexate and anti-tumor necrosis factor (TNF) biological agents. Although successful in the treatment of several CD or UC conditions, these drugs have limited effectiveness, and variable responses may culminate in unpredictable outcomes. The ideal therapy should reduce inflammation without inducing immunosuppression, and remains a challenge to health care personnel. Recently, a number of additional approaches to IBD therapy, such as new target molecules for biological agents and cellular therapy, have shown promising results. A deeper understanding of IBD pathogenesis and the availability of novel therapies are needed to improve therapeutic success. This review describes the overall key features of therapies currently employed in clinical practice as well as novel and future alternative IBD treatment methods.


Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Attention Deficit Disorder with Hyperactivity/diagnosis , Psychiatric Status Rating Scales , Attention Deficit Disorder with Hyperactivity/psychology , Cross-Cultural Comparison , Factor Analysis, Statistical , Hyperkinesis/psychology , Impulsive Behavior/physiology , Psychometrics , Reproducibility of Results , Self Report , Spain
9.
Article in Korean | WPRIM | ID: wpr-88234

ABSTRACT

Takotsubo cardiomyopathy (TC) is a transient form of acute heart failure that most often occurs in postmenopausal women, typically triggered by a preceding emotional or physical stressor. A 74-year-old woman who suffered from chronic psychiatric stress visited National Medical Center for dyspnea. Acute emotional or physical stress could not be identified despite careful history taking. An electrocardiogram showed diffuse T-wave inversions with prolonged QT interval, and the echocardiogram showed akinesia of mid and apical segments of the left ventricle with hyperkinesia at the base. There was no significant stenosis on coronary angiography. Differing from the typical case of TC, which follows acute stress triggers, our case indicates that underlying chronic psychiatric illness exacerbation can lead to TC. We suggest that cardiologists and psychiatrists be aware of this predisposition to TC, especially in the circumstances of acute heart failure.


Subject(s)
Aged , Female , Humans , Cardiomyopathies , Constriction, Pathologic , Coronary Angiography , Depressive Disorder, Major , Dyspnea , Electrocardiography , Heart Failure , Heart Ventricles , Hyperkinesis , Psychiatry , Takotsubo Cardiomyopathy
10.
Univ. psychol ; 13(4): 1267-1277, oct.-dic. 2014. ilus, tab
Article in English | LILACS | ID: lil-751231

ABSTRACT

The Executive Function is a set of cognitive processes that are developed from the earliest ages. Recent studies in children with disruptive behaviour disorders suggest the presence of effects on the executive functioning. The aim of this study is to know the association among symptoms of Attention Deficit with Hyperactivity Disorder, Oppositional Defiant Disorder, and Conduct Disorder, and Executive Function in children from 3 to 6 years old. Method: A descriptive cross-sectional study was conducted. An assessment was performed on a sample of 444 subjects from Spain; it was made through an inventory for parents and teachers to estimate the capacity of Executive Function. Results: a relation between the symptoms of Attention Deficit with Hyperactivity Disorder, Oppositional Defiant Disorder, Conduct Disorder, and the Executive Function deficit was found. The presence of symptoms of Attention Deficit with Hyperactivity Disorder inattentive type is associated with deficiencies in all areas of Executive Function, which does not occur with other symptoms. Conclusion: It is important to know the specific characteristics of each symptomatology by taking into account their executive functioning, in order to achieve accurate diagnoses in the clinical setting, as well as appropriate therapy according to the deficiencies presented by children.


Las funciones ejecutivas son un conjunto de procesos cognitivos que se desarrollan desde los estadios iniciales. Recientes estudios en niños con trastorno de comportamiento adaptativo sugieren la presencia de efectos sobre el funcionamiento ejecutivo. El objetivo del presente trabajo es conocer la asociación entre síntomas del síndrome por déficit de atención con hiperactividad, síndrome opositivo desafiante y trastorno de conducta y función ejecutiva en niños de 3 a 6 años. La investigación de tipo descriptivo transversal se llevó a cabo sobre una muestra de 444 niños españoles. Para estimar la capacidad de funciones ejecutivas, se estructuró un inventario para padres y educadores. Se encontró una relación entre los síntomas del síndrome de défict de atención con hiperactividad, síndrome opositivo desafiante y trastorno de conducta, y déficit en funciones ejecutivas. La presencia de los síntomas del síndrome de défict de atención con hiperactividad de tipo inatento se asoció con deficiencias en todas las áreas de funciones ejecutivas, lo que no ocurre con otros síntomas. Por lo tanto, es importante conocer las características específicas de cada sintomatología, tomando en cuenta su funcionamiento ejecutivo, con el ánimo de lograr diagnósticos adecuados en el ámbito clínico y la terapia apropiada acorde a las deficiencias presentadas en niños.


Subject(s)
Child , Conduct Disorder , Hyperkinesis
11.
Article in English | WPRIM | ID: wpr-162339

ABSTRACT

Stress cardiomyopathy (SCMP) is characterized by a transient left ventricular dysfunction associated with apical ballooning and compensatory hyperkinesias of the basal segments after emotional or physical stress, but inverted or mid-ventricular variants of SCMP have also been described. Although catecholamine excess has been suggested as a possible pathophysiologic mechanism of SCMP, the etiology of SCMP is still unknown. Here, we report a case of inverted type of SCMP with clinical presentation mimicking acute coronary syndromes. The cause or precipitating stressor was unclear initially, but pheochromocytoma has been demonstrated as a cause of SCMP during clinical follow-up at out-patient clinic in the present case. Catecholamine-producing tumors should be included in the evaluation or management of SCMP, even though initial clinical manifestations are not suggestive for pheochromocytoma.


Subject(s)
Humans , Acute Coronary Syndrome , Cardiomyopathies , Follow-Up Studies , Hyperkinesis , Outpatients , Pheochromocytoma , Takotsubo Cardiomyopathy , Ventricular Dysfunction, Left
12.
Article in Chinese | WPRIM | ID: wpr-315774

ABSTRACT

<p><b>OBJECTIVE</b>To study the impact in response control, attention and hyperactivity behavior on children with obstructive sleep apnea hypopnea syndrome (OSAHS) by the integrated visual and auditory continuous performance test (IVA-CPT).</p><p><b>METHODS</b>Fifty-one children aged between 5 and 12 years were diagnosed as OSAHS by polysomnography (PSG), and received adenotonsillectomy and adenoidectomy or only adenoidectomy. Then received IVA-CPT and PSG before surgery, 3 months after surgery and 6 months after surgery (named as first, second and third time point). These children were divided into two groups according to the disease course (group A: course of disease < 5 years; group B: course of disease ≥ 5 years). The SPSS 19.0 was used for statistical analysis.</p><p><b>RESULTS</b>By balanced test, there were no differences in gender, body mass index (BMI) and disease severity among the two groups before surgery (P > 0.05). The numbers of children with abnormal psychological behavior at three time points were 32 (62.7%), 25 (49.0%) and 8 (15.7%). The abnormal rate did not show statistical difference between the first and second time point (χ(2) = 1.49, P = 0.163), but did show statistical difference between the second and third time point (χ(2) = 12.95, P < 0.001). Repetitive measurement and analysis of variance showed that there were statistical differences in means of FRCQ, FAQ and HYP between three time points in two groups (F were 342.15, 263.12, 380.57, P < 0.001), and all the means improved with time. It also showed that there were statistical differences in means of FRCQ, FAQ and HYP between two groups at every time point (F were 167.05, 126.47, 117.683, P < 0.001). FRCQ and HYP all showed interation effect between two groups (P < 0.001). Means of apnea hypopnea index (AHI) and lowest arterial (LaSO2) were compared between three time points in two groups and all showed statistical differences (F were 99.057, 70.742, P < 0.001). Means of AHI and LaSO2 were compared between two groups at every time point. AHI and LaSO2 did not show statistical difference (P > 0.05). AHI and LaSO2 did not exist interation effect of disease course and time.</p><p><b>CONCLUSIONS</b>OSAHS obviously affect the children's response control, attention and hyperactivity behavior, but can recover gradually after adenotonsillectomy and adenoidectomy or only adenoidectomy. Therefore, Children with OSAHS should receive treatment as early as possible so as to reduce the influence on psychology.</p>


Subject(s)
Child , Child, Preschool , Female , Humans , Male , Adenoidectomy , Attention , Hyperkinesis , Impulsive Behavior , Neuropsychological Tests , Sleep Apnea, Obstructive , General Surgery , Tonsillectomy
13.
Article in Chinese | WPRIM | ID: wpr-235364

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the method and mechanism for exercise-related immunosuppression via the inhibitor of NADPH oxidase diphenyleneiodonium(DPI) and glutamine supplementation and on the function of neutrophils after overtraining.</p><p><b>METHODS</b>Fifty male Wistar rats were randomly divided into five groups: a negative control group (C), an overtraining group (E), an overtraining + DPI intervention group (D), an overtraining+ glutamine supplementation group(G) and combined glutamine + DPI intervention group(DG). After 36 - 40 h from the last training, eight rats were randomly selected from each group, and blood was sampled from the orbital vein. ELISAs were used to measure serum cytokine levels and lipid peroxidation in blood plasma. Flow cytometry was used to measure neutrophil respiratory burst and phagocytosis. The activity of NADPH oxidase was assessed by chemiluminescence and the gene expression of gp91(phox) and p47(phox) of the NADPH-oxidase subunit was checked by Western blot.</p><p><b>RESULTS</b>Compared with group C, the plasma concentrations of NO increased in group G, and the NO, cytokine-induced neutrophil chemoattractant (CINC) concentrations in group DG increased significantly. The respiratory burst and phagocytosis function of neutrophils were decreased in group E, but in group DG were increased when compared with those of group E. After overtraining the expression of gp91(phox) and p47(phox) was up regulated in group E. There were no significant changes in other groups except group DG, in which the expression of gp91(phox) was down regulated. Compared with group E, the expression of gp91(phox) and p47(phox) was up regulated in group D, group G and group DG.</p><p><b>CONCLUSION</b>The activation of NADPH oxidase is responsible for the production of superoxide anions, which may be related to the decrease in neutrophil function after over training and is the mechanism of exercise-related immunosuppression. The DPI treatment combined glutamine supplementation can reverse the decrease neutrophils function after overtraining in vitro.</p>


Subject(s)
Animals , Male , Rats , Dietary Supplements , Glutamine , Pharmacology , Hyperkinesis , Membrane Glycoproteins , Metabolism , NADPH Oxidase 2 , NADPH Oxidases , Metabolism , Neutrophils , Metabolism , Physiology , Onium Compounds , Pharmacology , Oxidation-Reduction , Rats, Wistar , Respiratory Burst , Physiology
14.
Psychiatry Investigation ; : 417-420, 2013.
Article in English | WPRIM | ID: wpr-126137

ABSTRACT

Fluvoxamine is a selective serotonin reuptake inhibitor that is approved for psychiatric disorders such as major depressive episodes and obsessive-compulsive disorder. Beside inhibition of serotonin reuptake, fluvoxamine is also a potent agonist of endoplasmic reticulum (ER) protein sigma-1 receptors, which play a role in the pathophysiology of a number of psychiatric and neurodegenerative disorders. This report presents beneficial effects of sigma-1 agonist fluvoxamine on hyperkinetic movement disorders such as tardive dyskinesia and tardive akathisia. Fluvoxamine might be a novel treatmet approach in the treatment of hyperkinetic movement disorders.


Subject(s)
Humans , Akathisia, Drug-Induced , Dyskinesias , Endoplasmic Reticulum , Fluvoxamine , Hyperkinesis , Movement Disorders , Neurodegenerative Diseases , Obsessive-Compulsive Disorder , Psychomotor Agitation , Receptors, sigma , Schizophrenia , Serotonin
15.
Article in English | WPRIM | ID: wpr-633176

ABSTRACT

OBJECTIVES: To present a case of anti NMDA receptor encephalitis in an adolescent male; to report a case of anti-NMDA receptor encephalitis who showed a rapid response to methylprednisone. INTRODUCTION: Anti NMDA receptor encephalitis is an inflammatory encephalopathic autoimmune disease frequently affecting young women with teratomas of the ovary. It is also observed in men, children, and females without tumors. THE CASE: A case of a 14 year adolescent right handed male adolescent presented with fever, hypertension , psychiatric symptom ,aphasia and orofacial dyskinesia. On admission he was highly febrile with dysautonomia, rigidity, catatonia and prominent orofacial dyskinesia. Upper motor signs include hyperreflexia and bilateral clonus. He latter developed Ileus, bladder and bowel incontinence, seizures, chorea, dystonia and dIe orofacial dyskinesia worsened. EEG showed continuous background slowing, Cranial MRI was normal and CSF analysis showed pleocytosis with lymphatic predominance with a normal protein and sugar. Work up for Herpes and Japanese B encephalitis was negative. Work up for tumor was negative. After 5 days of methylprednisone a rapid improvement was noted with resolution catatonia, rigidity hypereflexia and clonus. Results of the anti NMDA receptor antibodies showed positive for anti NMDA receptor encephalitis. DISCUSSION: Anti NMDA receptor encephalitis presents with fever, headache,or malaise, followed mood and behavioral changes, psychiatric symptoms, decline of level of consciousness, hypoventilation and hyperkinesias. Immunotherapy is the current treatment. In patients with underlying tumor, immunotherapy, enhanced the effectiveness and speed of recovery. In patients without a tumour an additional treatment with second-line immunotherapy is needed but was not noted in this case. The patient showed a rapid recovery after methylprednisone and after 4 months post immunotherapy there was no recurrence of symptoms. CONCLUSION: Anti NMDA receptor encephalitis is an inflammatory encephalopathic autoimmune disease and can be seen in children without tumors. Behavioral and hyperkinesias are prominent symptoms. Treatment with methylprednisone showed a good response.


Subject(s)
Humans , Male , Adolescent , Anti-N-Methyl-D-Aspartate Receptor Encephalitis , Catatonia , Chorea , Dyskinesias , Dystonia , Electroencephalography , Encephalitis, Japanese , Hashimoto Disease , Hyperkinesis , Leukocytosis , Primary Dysautonomias , Receptors, N-Methyl-D-Aspartate
16.
Psychiatry Investigation ; : 191-194, 2012.
Article in English | WPRIM | ID: wpr-120911

ABSTRACT

Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Three single nucleotide polymorphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. There were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.


Subject(s)
Humans , Antipsychotic Agents , Apoptosis , Gene Frequency , Genotype , Haplotypes , Hyperkinesis , Movement Disorders , Polymorphism, Single Nucleotide , Prostate , Receptors, Dopamine D2 , Schizophrenia
17.
Article in English | WPRIM | ID: wpr-56886

ABSTRACT

Mixed autonomic hyperactivity disorder (MAHD) among patients with acquired brain injury can be rare. A delayed diagnosis of MAHD might exacerbate the clinical outcome and increase healthcare expenses with unnecessary testing. However, MAHD is still an underrecognized and evolving disease entity. A 25-yr-old woman was admitted the clinic due to craniopharyngioma. After an extensive tumor resection, she complained of sustained fever, papillary contraction, hiccup, lacrimation, and sighing. An extensive evaluation of the sustained fever was conducted. Finally, the cause for MAHD was suspected, and the patient was successfully treated with bromocriptine for a month.


Subject(s)
Adult , Female , Humans , Brain/diagnostic imaging , Bromocriptine/therapeutic use , Craniopharyngioma/complications , Fever/complications , Hormone Antagonists/therapeutic use , Hyperkinesis/complications , Magnetic Resonance Imaging , Neurosurgical Procedures/adverse effects , Pituitary Neoplasms/complications , Tomography, X-Ray Computed
18.
Rev. chil. nutr ; 38(1): 70-75, mar. 2011. ilus, tab
Article in Spanish | LILACS | ID: lil-592077

ABSTRACT

Introduction: An increased basal metabolism rate and hyperphagia associated with weight loss are among the main clinical manifestations of hyperthyroidism. However, few literature reports are available regarding the adequacy of calorie consumption based on the energy expenditure of the patient. Case Report: A 24-year-old male patient (weight 61.5 kg, height 1.78 m) with a diagnosis of hyperthyroidism due to Graves' disease and initial hormone values consistent with this disease (free T3=17,6 pg/ml; free T4>6,0 ng/dl; TSH<0,004 IU/ml). Indirect calorimetry was performed in order to estimate real energy expenditure and adequacy of the nutritional conducts adopted during hospitalization. The patient had a resting energy expenditure of2574 kcal. Conclusion: The present study suggests that the measurement of energy expenditure by indirect calorimetry is an important tool for the evaluation of the energy requirements and diet adequacy of a patient with thyrotoxicosis due to Graves' disease.


Introducción: El aumento del metabolismo basal, hiperfagia asociada con pérdida de peso son algunas de las principales manifestaciones clínicas que ocurren en el hipertiroidismo. Sin embargo, hay pocos estudios disponibles acerca de la necessidad y del gasto energético del paciente. Caso clínico: Varón de 24 años de edad con 61,5 kg de peso y estatura de 1,78 m, con el diagnóstico de hipertiroidismo por enfermedad de Graves (T3 libre = 17,6 pg/ml; T4 livre >6,0 ng/dl; TSH <0,004 IU/ml) y con los siguientes síntomas: pérdida de peso, aumento de apetito y hiperactividad. La calorimetría indirecta se realizó para estimar el consumo energético real para definir la conduta nutricional durante la hospitalización. El gasto energético basal fue de 2574 kcal. Conclusión: El presente estudio sugiere que la medición del gasto energético por calorimetría indirecta es una herramienta importante para la evaluación de las necesidades de energía y la adecuación de la dieta de un paciente con tirotoxicosis por enfermedad de Graves. Se necesitan más estudios para determinar el impacto de esta conducta en la evaluación de la respuesta al tratamiento del hipertiroidismo.


Subject(s)
Humans , Male , Adult , Calorimetry/methods , Graves Disease , Hyperphagia , Hyperkinesis/diagnosis , Basal Metabolism/physiology , Nutritional Physiological Phenomena
19.
Psychol. av. discip ; 5(1): 95-105, Jan.-June 2011. ilus, tab
Article in Spanish | LILACS | ID: lil-659459

ABSTRACT

El propósito de esta investigación de tipo tecnológica psicométrica, fue construir y validar un instrumento que hiciera parte del proceso exploratorio del trastorno por déficit de atención con hiperactividad (TDAH) llamada Escala del Trastorno por Déficit de Atención con Hiperactividad (ETDAH). La muestra estuvo conformada por padres y maestros de 315 niños de 7 a 10 años de seis colegios de Tunja. El instrumento comprendió una escala para padres con una confiabilidad de 0,93, una validez de constructo de 0,96 y en la escala para maestros de .97 y .97 respectivamente. El análisis factorial sugirió tres factores en la escala de padres y dos factores en la escala de docentes. Las comparaciones por grupos demostraron la pertinencia de realizar baremos de interpretación según edad y género.


The purpose of this investigation of psychometric technology type, was to construct and validate an instrument that is part of the exploratory process of attention deficit hyperactivity disorder (ADHD) called Scale of t Attention Deficit Hyperactivity Disorder (ETDAH). The sample consisted of parents and teachers of 315 children from 7 to 10 years in six schools in Tunja. The instrument included a parent scale with a reliability of 0.93, construct validity of 0.96 and teacher scale of .97 and .97 respectively.Factor analysis suggested three factors in the scale of parents and two factors in the scale of teachers. The group comparisons showed the relevance of performing scales of interpretation according to age and gender.


Subject(s)
Psychometrics , Attention Deficit Disorder with Hyperactivity , Reproducibility of Results , Factor Analysis, Statistical , Integrated Management of Childhood Illness , Child , Hyperkinesis
20.
Article in English | WPRIM | ID: wpr-90275

ABSTRACT

PURPOSE: Takotsubo cardiomyopathy is a relatively uncommon type of stress-induced cardiomyopathy characterized by transient left ventricular regional wall motion abnormalities. Emotional and physical stresses play a key role in this type of cardiomyopathy in postmenopausal women. The current hypothesis is that the syndrome represents a form of catecholamine surge due to stress or epinephrine-mediated acute myocardial stunning. METHODS: A 44-year-old woman had suffered premature ventricular contraction following a cardiogenic shock during a breast augmentation surgery under enflurane anesthesia and tumescent solution infiltration. She was treated with cardiopulmonary resuscitation at a local clinic. Then she was brought to the Emergency Department of the authors' hospital. RESULTS: The woman's echocardiogram showed an ejection fraction of 20~25% with associated basal hyperkinesis and left ventricular apical ballooning. The patient was admitted to the ICU and required inotropic support for two weeks. The patient's condition dramatically improved, and her ejection fraction returned to 70%. CONCLUSION: It is believed that there were multiple triggering factors of the onset of Takotsubo cardiomyopathy in the woman's social and family history, including infiltration of a large volume of the tumescent solution and VPCs induced by enflurane anesthesia without premedication. The importance of careful history-taking, careful pre-operative consultation on psychological suffering especially for breast surgery, premedication before surgery, patient reassurance, and post-operative psychosocial and emotional assistance was again seen in this case.


Subject(s)
Adult , Female , Humans , Anesthesia , Breast , Cardiomyopathies , Cardiopulmonary Resuscitation , Emergencies , Enflurane , Hyperkinesis , Premedication , Shock, Cardiogenic , Stress, Psychological , Takotsubo Cardiomyopathy , Ventricular Premature Complexes
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