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1.
Braz. j. med. biol. res ; 54(10): e11035, 2021. tab, graf
Article in English | LILACS | ID: biblio-1285659

ABSTRACT

In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Climatic variables were obtained at the Center for Meteorological and Climatic Research Applied to Agriculture (University of Campinas - Unicamp, Brazil). The plasma lipid databases surveyed were from 27,543 individuals who had their lipid profiles assessed at the state university referral hospital in Campinas (Unicamp). The frequency of hospitalizations was obtained from the Brazilian Public Health database (DATASUS). Temporal statistical analyses were performed using the methods Cosinor or Friedman (ARIMA) and the temporal series were compared by cross-correlation functions. In normolipidemic cases (n=11,892), significantly different rhythmicity was observed in low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (C) both higher in winter and lower in summer. Dyslipidemia (n=15,651) increased the number and amplitude of lipid rhythms: LDL-C and HDL-C were higher in winter and lower in summer, and the opposite occurred with triglycerides. The number of hospitalizations showed maximum and minimum frequencies in winter and in summer, respectively. A coincident rhythmicity was observed of lower temperature and humidity rates with higher plasma LDL-C, and their temporal series were inversely cross-correlated. This study shows for the first time that variations of temperature, humidity, and daylight length were strongly associated with LDL-C and HDL-C seasonality, but moderately to lowly associated with rhythmicity of atherosclerotic outcomes. It also indicates unfavorable cardiovascular-related changes during wintertime.


Subject(s)
Humans , Cardiovascular Diseases/epidemiology , Climate , Lipids/blood , Lipoproteins/blood , Periodicity , Seasons , Triglycerides/blood , Brazil/epidemiology , Retrospective Studies , Cholesterol, HDL/blood
2.
Article in English | WPRIM | ID: wpr-880652

ABSTRACT

OBJECTIVES@#To analyze the effect of hyperlipoproteinemia (α) on immediate expansion after coronary stent implantation guided by intravascular ultrasound (IVUS).@*METHODS@#A total of 160 patients (175 lesions) with coronary heart disease diagnosed by coronary artery angiography, who were performed percutaneous intervention guided by IVUS in the Department of Cardiology, Third Xiangya Hospital, Central South University, were enrolled retrospectively.According to the concentration of lipoproteina, the patients were divided into 2 groups: a hyperlipoproteinemia (α) group and a control group. Cardiac ejection fraction was measured with echocardiography. Logistic regression was used to analyze the influential factors for hyperlipoproteinemia (α). The target vessel was examined by IVUS to analyze the immediate expansion effect of hyperlipoproteinemia (α) after stent implantation.@*RESULTS@#The mean stent expansion index, lesion length, stent number, stent symmetry index and posterior balloon diameter were (94.73±18.9)%, (52.92±29.1) mm, (2.11±0.85), (83.62±13.07)%, and (9.46±2.00) mm in the hyperlipoproteinemia (α) group, respectively. Compared with the control group, there were significantly difference (all @*CONCLUSIONS@#Hyperlipoproteinemia (α) appears to be a predictor of stent underexpansion, and the decreased creatinine clearance rate is an independent risk factor for hyperlipoproteinemia (α).


Subject(s)
Coronary Angiography , Coronary Artery Disease/surgery , Humans , Lipoproteins , Percutaneous Coronary Intervention/adverse effects , Retrospective Studies , Risk Factors , Stents/adverse effects , Treatment Outcome , Ultrasonography, Interventional
3.
São Paulo; s.n; 2020. 187 p.
Thesis in Portuguese | LILACS | ID: biblio-1147573

ABSTRACT

Introdução: Há necessidade de métodos para avaliar a qualidade de alimentos à base de cereais a fim de promover a conscientização dos consumidores, a reformulação de alimentos e esforços políticos como diretrizes, rotulagem e alegações de saúde. Nesse sentido, a presença de 1 g de fibra em 10 g de carboidrato (razão ≤10:1) tem sido proposta na identificação de alimentos à base de cereais com melhor qualidade nutricional. Objetivo: O objetivo do presente estudo foi investigar a aplicação da razão ≤10:1 na identificação de alimentos à base de cereais saudáveis, sua associação com fatores de risco cardiometabólico, avaliar o panorama do consumo desses alimentos e seus determinantes, assim como o potencial impacto nutricional de estratégias para aumentar o seu consumo na população do município de São Paulo. Métodos: Foram utilizados dados provenientes do Inquérito de Saúde de São Paulo de 2003, 2008 e 2015. Trata-se de um estudo transversal de base populacional com amostra representativa de indivíduos de 12 anos ou mais residentes na área urbana do município. Participantes responderam a um questionário semiestruturado, a pelo menos um recordatório alimentar de 24 horas, e tiveram coletadas amostras de sangue, antropometria e medidas de pressão arterial. Alimentos do grupo dos cereais que atenderam à razão ≤10:1 tiveram o valor nutricional comparado aos alimentos que não se enquadraram nesse critério por meio de regressão linear com variância robusta. Investigamos a associação entre o consumo de alimentos ≤10:1 e fatores de risco cardiometabólico por meio de regressão linear múltipla (primeiro manuscrito). O consumo desses alimentos nos anos 2003, 2008 e 2015 foi comparado por meio de testes de tendência e sua associação com características sociodemográficas foi investigada por meio de regressão logística, assim como a predição de consumo para os próximos anos (segundo manuscrito). O impacto nutricional da substituição do arroz branco e do pão branco por seus correspondentes integrais foi avaliado por meio de mudanças na média de ingestão de alimentos que atenderam à razão ≤10:1, energia e nutrientes (terceiro manuscrito). Resultados: Alimentos que atenderam à razão ≤10:1 apresentaram menor carboidrato disponível (-3,0 g/porção), açúcar total (-7,4 g/porção), açúcar de adição (-7,2 g/porção) e gordura saturada (-0,7 g/porção); e maior fibra alimentar (+3,5 g/porção), proteína (+2,1 g/porção), potássio (+100,1 mg/porção), ferro (+0,9 mg/porção), selênio (+4,2 µg/porção), magnésio (+38,7 mg/porção) e zinco (+1,1 mg/porção). Cada aumento de 1% de energia (E) desses alimentos foi associado a níveis sanguíneos mais baixos de triacilglicerol (-10,7%), razão triacilglicerol/HDL-c (-14,9%), insulinemia de jejum (-13,6%) e HOMA-IR (-14,0%). De 2003 a 2015, houve aumento no consumo cereais que atenderam à razão ≤10:1 (de 0,9%E para 1,5%E) e na proporção da população consumindo esses alimentos (de 8,7% para 15,8%). Estima-se que 19,9% da população consumirá algum tipo de cereal atendendo ao critério ≤10:1 em 2030. Maior chance de consumo desses alimentos foi observada entre indivíduos mais velhos (+78%), mulheres (+28%), pessoas com ensino superior (+137%) e níveis mais altos de renda familiar (+135%), enquanto participantes que relataram etnia negra, parda ou indígena apresentaram menor chance (-30%). A substituição do arroz branco e do pão branco por arroz integral e pão integral, respectivamente, resultaria em aumento da ingestão de zinco (9,1%), cálcio (9,3%), vitamina E (18,8%), fibra alimentar (27,0%) e magnésio (52,9%), e na diminuição de carboidratos totais (-6,1%), folato (-6.6%), carboidratos disponíveis (-8,5%), vitamina B6 (-12,5%), vitamina B2 (-17,4%), e vitamina B1 (-20,7%). A ingestão de alimentos que atenderam à razão ≤10:1 pré e pós-modelagem foi de 4,0% e 69,4% da ingestão de cereais totais, respectivamente, um aumento de 220 g/d. Conclusões: A razão ≤10:1 identificou alimentos à base cereais com maior qualidade nutricional e a maior ingestão desses alimentos foi associada à redução de fatores de risco cardiometabólico relacionados à dislipidemia aterogênica e resistência à insulina. De 2003 a 2015, houve aumento no consumo de cereais que atenderam à razão ≤10:1, mas esse consumo permanece abaixo dos níveis recomendados. Menor probabilidade de ingestão de alimentos que atenderam à razão ≤10:1 foi observada entre mais jovens, sexo masculino, com menor escolaridade e renda familiar e de etnia negra, parda e indígena, nesse período. A substituição de alimentos à base de cereais por opções equivalentes que atenderam à razão ≤10:1 pode levar a mudanças favoráveis no conteúdo nutricional da dieta, além de notável aumento na proporção de cereais que atenderam à razão ≤10:1 em relação aos cereais totais.


Introduction: There is a pressing need for methods to assess the healthfulness of grain foods to promote consumer awareness, evidence-informed industry reformulations, and policy efforts such as guidelines, labeling, and health claims. In this sense, the presence per 10 g of carbohydrate of at least 1 g of fiber (≤10:1-ratio) has been proposed as a pragmatic metric to identify healthier grain products. Objective: To investigate the application of the ≤10:1-ratio to identify healthful grain foods, and its association with cardiometabolic risk factors, to evaluate trends and determinants of this intake, as well as to estimate the potential nutritional impact of strategies to increase the consumption of these foods in São Paulo population. Methods: Data came from the population-based study Health Survey of São Paulo (2003, 2008 and 2015). This is a cross-sectional, population-based study including a probabilistic sample of urban residents in São Paulo. Participants aged 12+ years answered a structured questionnaire, at least one 24-h dietary recall, had blood sample, anthropometric and blood pressure measurements collected. The nutritional value of grain foods meeting the ≤10:1-ratio was compared to grain foods not meeting this criterion using univariate linear regressions with robust variance. The association between the intake of grain foods meeting the ≤10:1-ratio and cardiometabolic risk factors was assessed by multivariable linear regression models (First manuscript). The consumption of grain foods meeting the ≤10:1-ratio from 2003 to 2015 was investigated using linear regression models. Determinants of these intakes and prediction of the prevalence of intake for the next years were estimated using multivariable logistic regression models (Second manuscript). We estimated the potential nutritional impact of replacing white rice and white bread with healthful equivalent options in mean change of healthful grain foods, energy and nutrients intake (Third manuscript). Results: Foods meeting the ≤10:1-ratio had lower available carbohydrate (-3.0 g/serving), total sugar (-7.4 g/serving), added sugar (-7.2 g/serving) and saturated fatty acids (-0.7 g/serving), as well as more dietary fiber (+3.5 g/serving), protein (+2.1 g/serving), potassium (+100.1 mg/serving), iron (+0.9 mg/serving), selenium (+4.2 µg/serving), magnesium (+38.7 mg/serving) and zinc (+1.1 mg/serving). Each increase in 1% of energy (E) of these foods was associated with lower levels of blood triacylglycerol (-10.7%), the triacylglycerol/HDL-c ratio (-14.9%), fasting insulin (-13.6%), and HOMA-IR (-14.0%). From 2003 to 2015, a growing trend in the intake of grain foods meeting the ≤10:1-ratio (from 0.9 %E to 1.5%E) was observed. Also, the proportion of the population consuming at least one-grain food meeting the ≤10:1-ratio increased from 8,7% in 2003 to 15,8% in 2015, and 19,9% of the population would be consuming some kind of healthful gain food by 2030. Older individuals (+78%), females (+28%), those with higher education (+137%), and higher family income (+135%) were more likely to consume grain foods meeting the ratio, whereas participants who self-reported black, brown or indigenous ethnicity were less likely to consume these foods (-30%). The substitution of white rice and white bread for brown rice and whole wheat bread, respectively, would result in increased intake of zinc (9.1%), calcium (9.3%), vitamin E (18.8%), dietary fiber (27.0%) and magnesium (52,9%), while decreased intake of total carbohydrate (-6.1%), available carbohydrate (-8.5%), vitamin B6 (-12,5%), vitamin B2 (-17,4%), and vitamin B1 (-20,7%) would be seen. Pre- and post-modeled healthful grain foods intake were 4,0% and 69,4% of total grain intake, respectively, an increase of 220 g/d. Conclusion: The ≤10:1-ratio identified grain foods with higher nutritional quality, and higher intakes of these foods were associated with cardiometabolic risk factors related to atherogenic dyslipidemia and insulin resistance. There was a growing trend to consume grain foods meeting the ≤10:1-ratio from 2003 to 2015, but this consumption continues to be far from recommended levels. Overall, younger individuals, males, those with lower education levels, lower family income, and who self-reported black, brown or indigenous ethnicity were less likely to consume grain foods meeting the ≤10:1-ratio from 2003 to 2015. Shifting consumption from usually eaten grain foods to healthful equivalent options may lead to favorable changes in nutrient content of the diet, in addition to a remarkable increase in healthful grain foods intake.


Subject(s)
Socioeconomic Factors , Insulin Resistance , Carbohydrates , Dietary Fiber , Whole Foods , Nutritional Sciences , Lipoproteins
4.
NAJFNR ; 4(7): 268-279, 2020.
Article in English | AIM | ID: biblio-1266919

ABSTRACT

Aim : The main objective of our work was to assess the relationship between type 2 diabetes, hyperuricemia and dyslipidemia in the population of Tizi-Ouzou. By evaluating the relationship between hyperuricemia and some blood lipid parameters, we thus establish, in type 2 diabetes, the correlation between uremia and these lipid parameters. Subjects and methods: The survey was carried out by means of an individual questionnaire. We excluded from our study pregnant women, patients with cancer, patients with end-stage renal disease and subjects who did not respond to the questionnaire. Results: Serum uric acid level increased with age (p = 0.025). Hyperuricemia was associated with heart disease (p = 0.0007). All patients with gout presented an elevated serum uric acid (p = 0.000001). Dyslipidemia was more common in patients with elevated serum uric acid levels (p = 0.0008). Triglyceridemia was significantly associated with hyperuricemia (p = 0.025). The relationship between type 2 diabetes and glomerular filtration rate was not significant, while the latter was decreased in patients with elevated serum uric acid levels (p = 0.0001). In, stratified analysis, age was effect modifier, the age-dependent results make us understand that resistance to insulin constitutes a significant factor of hyperuricemia. Conclusion: The association between hyperuricemia and dyslipidemia in type 2 diabetes emphasizes that insulin resistance acts on both lipid parameters and uricemia. A diet correcting dyslipidemia may also correct the uricemia


Subject(s)
Algeria , Dyslipidemias , Hyperuricemia , Lipoproteins
5.
Article in Korean | WPRIM | ID: wpr-811453

ABSTRACT

Research on physical activity and health is actively being conducted. In the Korea National Health and Nutrition Examination Survey (KNHANES), the Global Physical Activity Questionnaire (GPAQ) was newly introduced in 2014. The purpose of this study was to investigate the levels of physical activity and related factors in Koreans who were assessed through the GPAQ by dividing the physical activity by occupation, leisure, and transport domain. This study used data from the KNHANES (2014–2016), the study population of which included 17,357 participants aged 12 to 80 years. We compared the differences in physical activity by sociodemographic factors, health-related factors, and psychological health-related factors. Moreover, we also compared the mean metabolic equivalent of task and daily sitting time according to physical activity domain by sex and age group. Finally, we investigated the sociodemographic factors, health-related factors, and psychological health-related factors that significantly affect the average physical activity per week. The various factors were found to differ in the frequency of physical activity levels. In addition, there was a difference in the amount of physical activity per occupation, leisure, and transport domain in each age group. Finally, age, sex, high-density lipoprotein cholesterol levels, arthritis, allergic rhinitis and sinusitis, sleeping time, and perceived health status significantly affected physical activity. The levels of physical activity significantly differed by sociodemographic factors, health-related factors, and psychological health-related factors. There was also a difference in the physical activity levels according to the age and sex per each domain of physical activity.


Subject(s)
Arthritis , Cholesterol , Humans , Korea , Leisure Activities , Lipoproteins , Metabolic Equivalent , Motor Activity , Nutrition Surveys , Occupations , Physical Fitness , Public Health , Rhinitis, Allergic , Risk Factors , Sinusitis , Social Determinants of Health , Surveys and Questionnaires
6.
Korean Circulation Journal ; : 236-247, 2020.
Article in English | WPRIM | ID: wpr-811355

ABSTRACT

BACKGROUND AND OBJECTIVES: Recent studies have examined the structure-function relationship of high-density lipoprotein (HDL). This study aimed to identify and rank HDL-associated proteins involved in several biological function of HDL.METHODS: HDLs isolated from 48 participants were analyzed. Cholesterol efflux capacity, effect of HDL on nitric oxide production, and vascular cell adhesion molecule-1 expression were assessed. The relative abundance of identified proteins in the highest vs. lowest quartile was expressed using the normalized spectral abundance factor ratio.RESULTS: After adjustment by multiple testing, six proteins, thyroxine-binding globulin, alpha-1B-glycoprotein, plasma serine protease inhibitor, vitronectin, angiotensinogen, and serum amyloid A-4, were more abundant (relative abundance ratio ≥2) in HDLs with the highest cholesterol efflux capacity. In contrast, three proteins, complement C4-A, alpha-2-macroglobulin, and immunoglobulin mu chain C region, were less abundant (relative abundance ratio <0.5). In terms of nitric oxide production and vascular cell adhesion molecule-1 expression, no proteins showed abundance ratios ≥2 or <0.5 after adjustment. Proteins correlated with the functional parameters of HDL belonged to diverse biological categories.CONCLUSIONS: In summary, this study ranked proteins showing higher or lower abundance in HDLs with high functional capacities and newly identified multiple proteins linked to cholesterol efflux capacity.


Subject(s)
Amyloid , Angiotensinogen , Atherosclerosis , Cardiovascular Diseases , Cholesterol , Complement System Proteins , Immunoglobulin mu-Chains , Lipoproteins , Nitric Oxide , Plasma , Proteomics , Serine Proteases , Thyroxine-Binding Globulin , Vascular Cell Adhesion Molecule-1 , Vitronectin
7.
Korean Circulation Journal ; : 248-249, 2020.
Article in English | WPRIM | ID: wpr-811354

ABSTRACT

No abstract available.


Subject(s)
Lipoproteins , Wind
8.
Article in English | WPRIM | ID: wpr-811204

ABSTRACT

Homozygous familial hypercholesterolemia (HoFH) is a rare inherited disorder that presents as abnormally elevated levels of low-density lipoprotein cholesterol and premature heart disease, requiring frequent intervention through lipid apheresis for management. The risk of perioperative cardiac events is higher in patients with HoFH because of its pathophysiological manifestations in the vascular system. Careful cardiac precautions and anesthetic assessments are necessary to ensure patient safety. In the following case report, we discuss the clinical course and anesthetic considerations for a 14-year-old girl with HoFH undergoing sedation for dental extractions and mandibular molar uprighting in an outpatient oral surgery clinic. Considerations included the use of heparin in the patient's weekly plasma lipid apheresis treatment. In order to reduce the risks of peri- and postoperative bleeding and perioperative cardiac events, the operation was scheduled for 4 days after apheresis. This allowed for adequate heparin clearance, while also reducing the likelihood of possible cardiac events. A literature review revealed no results for the outpatient management of patients with HoFH undergoing sedation for noncardiac procedures. Our reported case serves as a clinical example for physicians to be utilized in the future.


Subject(s)
Adolescent , Anesthesia, Dental , Blood Component Removal , Cholesterol , Female , Heart Diseases , Hemorrhage , Heparin , Humans , Hyperlipoproteinemia Type II , Lipoproteins , Molar , Outpatients , Patient Safety , Plasma , Surgery, Oral
9.
Article in English | WPRIM | ID: wpr-811146

ABSTRACT

BACKGROUND: Cardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for preventing cardiovascular events. The aim of this study was to assess the efficacy and tolerability of omega-3 fatty acids (OM3-FAs) in combination with atorvastatin compared to atorvastatin alone in patients with mixed dyslipidemia.METHODS: This randomized, double-blind, placebo-controlled, parallel-group, and phase III multicenter study included adults with fasting triglyceride (TG) levels ≥200 and <500 mg/dL and LDL-C levels <110 mg/dL. Eligible subjects were randomized to ATOMEGA (OM3-FAs 4,000 mg plus atorvastatin calcium 20 mg) or atorvastatin 20 mg plus placebo groups. The primary efficacy endpoints were the percent changes in TG and non-HDL-C levels from baseline at the end of treatment.RESULTS: After 8 weeks of treatment, the percent changes from baseline in TG (−29.8% vs. 3.6%, P<0.001) and non-HDL-C (−10.1% vs. 4.9%, P<0.001) levels were significantly greater in the ATOMEGA group (n=97) than in the atorvastatin group (n=103). Moreover, the proportion of total subjects reaching TG target of <200 mg/dL in the ATOMEGA group was significantly higher than that in the atorvastatin group (62.9% vs. 22.3%, P<0.001). The incidence of adverse events did not differ between the two groups.CONCLUSION: The addition of OM3-FAs to atorvastatin improved TG and non-HDL-C levels to a significant extent compared to atorvastatin alone in subjects with residual hypertriglyceridemia.


Subject(s)
Adult , Atorvastatin , Cholesterol , Cholesterol, LDL , Dyslipidemias , Fasting , Fatty Acids, Omega-3 , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Hypertriglyceridemia , Incidence , Lipoproteins , Triglycerides
12.
Article in English | WPRIM | ID: wpr-786074

ABSTRACT

OBJECTIVE: Postmenopausal women show a more atherogenic lipid profile and elevated cardiovascular risk compared to premenopausal women. The aim of this study was to investigate the efficacy and safety of high-dose atorvastatin on the improvement of the blood lipid profile of postmenopausal women in Korea.METHODS: This study is a prospective, open-label, single-arm clinical trial that was conducted in 3 teaching hospitals. Postmenopausal women with a moderate-to-high cardiovascular risk, according to guidelines from the Korean Society of Lipid & Atherosclerosis, were enrolled. Participants were administered 20 mg of atorvastatin daily for the first 8 weeks, and if the targeted low-density lipoprotein cholesterol (LDL-C) level was not achieved, the dose was increased to 40 mg for the second 8 weeks. The primary endpoint was percentage change of LDL-C from baseline after 16 weeks of drug administration.RESULTS: Forty-four women were enrolled, 28 of whom (75.6%) had diabetes mellitus. By the end of treatment period (16 weeks) all patients had achieved LDL-C target levels, with 33 (94.2%) of the participants achieving it after only 8 weeks of administration. After 16 weeks, LDL-C decreased by 45.8±16.7% (p<0.001) from the baseline, and total cholesterol (33.2±10.9%; p<0.001), triglyceride (24.2±37.5%; p=0.001), and apolipoprotein B (34.9±15.6%; p<0.001) also significantly decreased. Blood glucose and liver enzyme levels slightly increased, but none of the participants developed serious adverse events that would cause them to prematurely withdraw from the clinical trial.CONCLUSION: 20 and 40 mg atorvastatin was effective and safe for treating dyslipidemia in postmenopausal Korean women with moderate-to-high cardiovascular risk.


Subject(s)
Apolipoproteins , Asian Continental Ancestry Group , Atherosclerosis , Atorvastatin , Blood Glucose , Cholesterol , Diabetes Mellitus , Dyslipidemias , Female , Hospitals, Teaching , Humans , Korea , Lipoproteins , Liver , Postmenopause , Prospective Studies , Triglycerides
13.
Article in English | WPRIM | ID: wpr-786071

ABSTRACT

OBJECTIVE: This study investigated whether serum bilirubin levels can predict the progression of carotid atherosclerosis in individuals with type 2 diabetes mellitus (T2DM).METHODS: This observational study included 1,381 subjects with T2DM in whom serial measurements of carotid intima-media thickness (CIMT) were made at 1- to 2-year intervals for 6–8 years. The progression of carotid atherosclerosis was defined as newly detected plaque lesions on repeat ultrasonography. After dividing total serum bilirubin levels into tertiles, the association between total serum bilirubin at baseline and plaque progression status was analyzed.RESULTS: Among 1,381 T2DM patients, 599 (43.4%) were categorized as having plaque progression in their carotid arteries. Those with plaque progression were significantly older; showed a higher prevalence of hypertension, abdominal obesity, and chronic kidney disease; and had a longer duration of T2DM, higher levels of total cholesterol (TC), triglycerides, and insulin resistance, and lower total bilirubin concentrations than those with no plaque progression. When total serum bilirubin levels were divided into tertiles, the highest tertile group was younger than the lowest tertile group, with higher levels of TC and high-density lipoprotein cholesterol. Multiple logistic regression analysis demonstrated that higher serum bilirubin levels were associated with a significantly lower risk of CIMT progression (odds ratio, 0.584; 95% confidence interval, 0.392–0.870; p=0.008). Age (p<0.001), body mass index (p=0.023), and TC (p=0.019) were also associated with the progression of carotid atherosclerosis in T2DM patients.CONCLUSION: Total serum bilirubin is independently associated with progression of atherosclerosis in the carotid arteries in T2DM patients.


Subject(s)
Atherosclerosis , Bilirubin , Body Mass Index , Carotid Arteries , Carotid Artery Diseases , Carotid Intima-Media Thickness , Cholesterol , Diabetes Mellitus, Type 2 , Humans , Hypertension , Insulin Resistance , Lipoproteins , Logistic Models , Obesity, Abdominal , Observational Study , Prevalence , Renal Insufficiency, Chronic , Triglycerides , Ultrasonography
14.
Article in English | WPRIM | ID: wpr-786070

ABSTRACT

OBJECTIVE: Previous studies have separately reported the contributions of dietary factors to the risk of cardiovascular disease (CVD) and its markers, including blood pressure (BP) and lipid profile. This study systematically reviewed the current evidence on this issue in the Korean population.METHODS: Sixty-two studies from PubMed and Embase were included in this meta-analysis. We performed a random-effects model to analyze pooled odds ratios (ORs) and hazard ratios (HRs) and their 95% confidence intervals (CIs) for the consumption of 14 food items, three macro- and eight micro-nutrients, two dietary patterns, and three dietary indices.RESULTS: An analysis of pooled effect sizes from at least four individual study populations showed significant associations between coffee consumption and CVD (OR/HR, 0.71; 95% CI, 0.52–0.97) and elevated/high triglycerides (TG) (OR, 0.84; 95% CI, 0.78–0.90), sugar-sweetened beverage intake and elevated BP (OR/HR, 1.20; 95% CI, 1.09–1.33), and milk and dairy intake and elevated/high TG and elevated high-density lipoprotein cholesterol (HDL-C) (OR/HR, 0.82; 95% CI, 0.76–0.89 for both). Carbohydrate consumption and the low-carbohydrate-diet score were consistently related to an approximately 25% risk reduction for elevated TG and HDL-C. A lower risk of elevated total cholesterol, but not low-density lipoprotein, was additionally observed for those with a higher low-carbohydrate-diet score. A healthy dietary pattern was only associated with a reduced risk of elevated TG in the Korea National Cancer Screenee Cohort (OR, 0.81; 95% CI, 0.67–0.98).CONCLUSION: This study showed that milk and dairy and coffee had protective effects for CVD and its risk factors, such as BP and lipid profile, while sugar-sweetened beverages exerted harmful effects.


Subject(s)
Asian Continental Ancestry Group , Beverages , Blood Pressure , Cardiovascular Diseases , Cholesterol , Coffee , Cohort Studies , Dyslipidemias , Humans , Hypertension , Korea , Lipoproteins , Milk , Odds Ratio , Risk Factors , Risk Reduction Behavior , Triglycerides
15.
Acta bioquím. clín. latinoam ; 53(4): 469-476, dic. 2019. graf, tab
Article in Spanish | LILACS | ID: biblio-1124024

ABSTRACT

El propósito de este estudio fue analizar los cambios post prandiales en el perfil lipídico en respuesta a una comida típica argentina. Se extrajo sangre a 33 mujeres voluntarias después de 12 h de ayuno (T0), 1 h después de un desayuno estandarizado (T1) y 1 h después de un almuerzo estandarizado (T2). Se midieron los niveles de: colesterol total, colesterol de lipoproteínas de alta densidad (C-HDL), colesterol de lipoproteínas de baja densidad (C-LDL) y triglicéridos. Los datos se analizaron utilizando la prueba t de Student pareada. Para cada analito se calculó la diferencia porcentual media (DM%) en T1 y T2 respecto de T0 y se comparó con el valor de referencia del cambio (VRC). Las DM% mayores al VRC se consideraron clínicamente significativas. En T1 y T2, los valores de C-HDL fueron más bajos que en T0, mientras que los valores de C-LDL en T1 fueron más bajos que en T0. Los niveles de triglicéridos fueron significativamente más altos en T1 que en T0. En todos los casos, la variabilidad fue estadísticamente significativa, aunque no clínicamente. En este estudio puede observarse que el perfil de lípidos en T1 y T2 no mostró diferencias clínicamente significativas con respecto a los valores basales.


The purpose of the present study was to analyze postprandial lipid profile changes in response to a typical Argentine meal. Blood was collected from 33 female volunteers after a 12 h fasting period (T0), 1 h after a standardized breakfast (T1) and 1 h after a standardized lunch (T2). The levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides were measured. Data were analyzed using paired Student's t-test. Mean difference % (MD %) was calculated for each analyte at T1 and T2 and was further compared with reference change value (RCV). MDs % higher than RCV were considered clinically significant. At T1 and T2, HDL-C values were lower than at T0, whereas LDL-C values at T1 were lower than at T0. Triglycerides levels were significantly higher at T1 than baseline values. In all cases, variability was statistically, though not clinically, significant. This study demonstrates that at T1 and T2 lipid profile showed no clinically significant differences with respect to basal values.


O objetivo do presente estudo foi analisar as alterações do perfil lipídico pós-prandial em resposta a uma refeição típica argentina. O sangue foi coletado de 33 mulheres voluntárias após um período de jejum de 12 horas (T0),1 h após um café da manhã padronizado (T1) e 1 h após um almoço padronizado (T2). Foram medidos os níveis de: colesterol total (CT), colesterol HDL (C-HDL), colesterol LDL (C-LDL) e triglicérides. Os dados foram analisados utilizando o teste t de Student pareado. A diferença média% (DM%) foi calculada para cada analito em T1 e T2 e foi comparada com o valor de mudança de referência (VRC). Os MDs% maiores que o VRC foram considerados clinicamente significativos. Em T1 e T2, os valores de C-HDL foram menores que em T0, enquanto os valores de C-LDL em T1 foram menores que em T0. Os níveis de triglicérides foram significativamente maiores em T1 do que os valores basais. Em todos os casos, a variabilidade foi estatisticamente, embora não clinicamente, significativa. Este estudo demonstra que no perfil lipídico em T1 e T2 não houve diferenças clinicamente significativas em relação aos valores basais.


Subject(s)
Humans , Triglycerides , Blood , Cholesterol , Fasting , Fasting/blood , Determination , Meals , Breakfast , Pre-Analytical Phase/statistics & numerical data , Lipids , Lipids/analysis , Lipoproteins , Cholesterol, HDL , Cholesterol, LDL , Powders , Referral and Consultation , Coffee , Lunch , Lipoproteins, LDL
16.
Acta méd. colomb ; 44(3): 8-15, July-Sept. 2019. tab
Article in English | LILACS, COLNAL | ID: biblio-1098019

ABSTRACT

Abstract Introduction: Free thyroxine (T4), free triiodothyronine thyroid (T3) and thyroid stimulating hormone (TSH) are recognized as regulators of lipid synthesis, mobilization and degradation. Objective: To find a relationship between dyslipidemia and thyroid disease in an adult population. Methods: This was a cross-sectional study of 819 individuals. TSH, free T4, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were measured. Results: The general population showed normal TC, normal LDL-C, low HDL-C, and elevated TG. The prevalence of dyslipidemia was as follows: elevated TC 31.9%, HDL-C <40 mg/dL 57.9%, elevated LDL-C 24.3% and TG ≥200 mg/dL 26%. The prevalence of TSH ≥4.6 mIU/L was 8.1%. The prevalence of overt hypothyroidism was 1.2%, and that of subclinical hypothyroidism was 6.7%. The prevalences of elevated TC in individuals with overt hypothyroidism and normal thyroid levels were 50.0% and 31.6%, respectively. However, in those with subclinical hypothyroidism, the prevalences were 43.6% and 31.0% (p=0.04) for elevated TC and 40.0% and 23.2% (p=0.006) for elevated LDL-C. A significant relationship was found between TSH ≥4.6 mIU/L and elevated TC (OR=1.9, p=0.01) and elevated LDL-C (OR=2.5, p=0.001); the frequency of elevated LDL-C was 2.2 times greater in people with subclinical hypothyroidism than in people with normal TSH levels. Conclusion: Given agricultural workers' particular socioeconomic conditions and access to the health system, it is important to design screening programs for biomarkers that allow early detection of changes in thyroid hormones, TSH and lipid profiles to provide this population with preventive interventions to reduce morbimortality due to cardiovascular events (Acta Med Colomb 2019; 44. DOI:https://doi.org/10.36104/amc.2019.1094).


Resumen Introducción: tiroxina libre (T4L), triyodo tironina libre (T3L) y hormona estimulante del tiroides (TSH), se reconocen como reguladoras de síntesis, movilización y degradación de lípidos. Objetivo: encontrar una relación entre dislipidemias y enfermedad tiroidea en una población adulta. Métodos: este fue un estudio de corte transversal, en 819 individuos. Se midieron TSH, T4L, colesterol total (CT), colesterol en lipoproteínas de baja densidad (C-LDL), colesterol en lipopro-teínas de alta densidad (C-HDL) y triglicéridos (TG). Resultados: la población general mostró CT, C-LDL normales, C-HDL bajo y TG elevados. La prevalencia de dislipidemia fue: CT elevado 31.9%, C-HDL < 40 mg/dL 57.9%. C-LDL alto 24.3% y TG ≥200 mg/dL, 26%. La frecuencia de TSH ≥ 4.6 mIU/L fue 8.1%. La prevalencia de hipotiroidismo manifiesto fue de 1.2% y la de hipotiroidismo subclínico de 6.7%. La prevalencia de CT elevado en individuos con hipotiroidismo manifiesto y en normales fue de 50.0% y 31.6% respectivamente. Mientras en hipotiroidismo subclínico fue de 43.6% y 31.0% p: 0.04 para CT (elevado); 40.0% y 23.2% p: 0.006 para C-LDL elevado. Se encontró relación significativa entre TSH ≥4.6 mIU/L con CT elevado (OR 1.9 p 0.01) y C-LDL elevada (OR 2.5 p: 0.001); la frecuencia de C-LDL elevado fue de 2.2 veces en personas con hipotiroidismo subclínico con relación a personas con niveles normales de TSH. Conclusión: en los trabajadores del agro, por sus particulares condiciones socioeconómicas y de acceso al sistema de salud, es importante diseñar programas de tamizaje de biomarcadores que permitan avizorar de manera precoz cambios en las hormonas tiroideas, TSH y perfil lipídico, para realizar intervenciones de prevención secundaria que contribuyan a la disminución de la morbimortalidad por eventos cardiovasculares. (Acta Med Colomb 2019; 44. DOI: https://doi.org/10.36104/amc.2019.1094).


Subject(s)
Humans , Male , Female , Middle Aged , Dyslipidemias , Hypothyroidism , Thyroid Hormones , Unified Health System , Farmers , Lipoproteins
18.
Arq. bras. cardiol ; 113(2): 197-204, Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1019399

ABSTRACT

Abstract Background: Elevated plasma levels of Lipoprotein(a) [Lp(a)] are recognized as a significant risk factor for atherosclerotic vascular disease. However, there are limited data regarding association between Lp(a) and recurrent heart failure (HF) in patients with chronic HF caused by coronary heart disease (CHD). Objective: Elevated levels of Lp(a) might have a prognostic impact on recurrent HF in patients with chronic HF caused by CHD. Methods: A total of 309 patients with chronic HF caused by CHD were consecutively enrolled in this study. The patients were divided into 2 groups according to whether Lp(a) levels were above or below the median level for the entire cohort (20.6 mg/dL): the high Lp(a) group (n = 155) and the low Lp(a) group (n = 154). A 2-sided p < 0.05 was statistically considered significant. Results: During the median follow-up period of 186 days, 31 cases out of a total of 309 patients (10.03%) could not be reached during follow-up. A Kaplan-Meier analysis demonstrated that patients with higher Lp(a) levels had a higher incidence of recurrent HF than those with lower Lp(a) levels (log-rank < 0.0001). A multivariate Cox regression analysis revealed that Lp(a) levels were independently correlated with the incidence of recurrent HF after adjustment of potential confounders (hazard ratio: 2.720, 95 % confidence interval: 1.730-4.277, p < 0.0001). Conclusions: In Chinese patients with chronic HF caused by CHD, elevated levels of Lp(a) are independently associated with recurrent HF.


Resumo Fundamento: Níveis plasmáticos elevados de lipoproteína (a) [Lp(a)] são reconhecidos como um fator de risco significativo para doença vascular aterosclerótica. No entanto, existem dados limitados sobre a associação entre a Lp(a) e insuficiência cardíaca (IC) recorrente em pacientes com IC crônica causada por doença arterial coronariana (DAC). Objetivo: Níveis elevados de Lp(a) podem ter um impacto prognóstico na IC recorrente em pacientes com IC crônica por DAC. Métodos: Um total de 309 pacientes com IC crônica causada por DAC foram consecutivamente incluídos neste estudo. Os pacientes foram divididos em 2 grupos de acordo com os níveis de Lp(a), acima ou abaixo do nível mediano de toda a coorte (20,6 mg/dL): o grupo Lp(a) alto (n = 155) e o grupo Lp ( a) baixo (n = 154). Um p < 0,05 bicaudal foi considerado estatisticamente significativo. Resultados: Durante a mediana do período de seguimento de 186 dias, 31 casos de um total de 309 pacientes (10,03%) não puderam ser contatados durante o acompanhamento. A análise de Kaplan-Meier demonstrou que pacientes com níveis mais elevados de Lp(a) apresentavam maior incidência de IC recorrente do que aqueles com níveis mais baixos de Lp(a) (log-rank < 0,0001). Uma análise de regressão multivariada de Cox revelou que os níveis de Lp(a) foram independentemente correlacionados com a incidência de IC recorrente após ajuste de potenciais fatores de confusão (hazard ratio 2,720, intervalo de confiança de 95%: 1,730-4,277, p < 0,0001). Conclusões: Em pacientes chineses com IC crônica causada por DAC, níveis elevados de Lp(a) estão associados de forma independente à IC recorrente.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Coronary Artery Disease/blood , Heart Failure/blood , Lipoproteins/blood , Recurrence , Reference Values , Time Factors , Coronary Artery Disease/complications , Echocardiography , Chronic Disease , Regression Analysis , Retrospective Studies , Risk Factors , Statistics, Nonparametric , Risk Assessment/methods , Kaplan-Meier Estimate , Heart Failure/etiology
20.
HU rev ; 45(2): 115-121, 2019.
Article in Portuguese | LILACS | ID: biblio-1048772

ABSTRACT

Introdução: Estudos relatam uma forte ligação entre as dislipidemias e as ateroscleroses. Por esta razão, exames como o perfil lipídico são realizados rotineiramente com o intuito de prevenção e monitoramento dessas doenças. A lipoproteína de baixa densidade possui grande destaque por apresentar maior relação com fatores de risco para o desenvolvimento de doenças ateroscleróticas. Métodos diretos de obtenção dos valores dessa lipoproteína são confrontados com resultados obtidos usualmente na rotina, através de equações que fornecem valores estimados. Objetivo: Comparar os métodos de diagnósticos utilizados para a obtenção da lipoproteína de baixa densidade através das Fórmulas de Friedewald e Martin com os resultados obtidos por metodologia automatizada, em pacientes atendidos em um Hospital Universitário de Juiz de Fora - MG. Material e Métodos: Foram coletadas amostras de sangue venoso para a obtenção do soro de 208 pacientes. Quantificaram-se os níveis de colesterol total, triglicerídeos e da lipoproteína de alta densidade para a obtenção da lipoproteína de baixa densidade através das equações de Friedewald e Martin. Resultados: Há uma correlação positiva entre os resultados de lipoproteína de baixa densidade calculados pelos métodos de Martin e direto (ρ=0,916), e uma correlação positiva entre os resultados pelos métodos de Friedewald e direto (ρ=0,915). Discussão: Foi observada uma correlação positiva entre os valores de colesterol e de lipoproteína de baixa densidade pelas três metodologias. O método de Bland-Altman foi utilizado para comparação dos resultados obtidos pelas equações e pela metodologia direta. Conclusão: Ainda que as equações de Friedewald e Martin tenham apresentado boa correlação com a lipoproteína de baixa densidade medida por metodologia direta, estudos que relacionam doenças arteriais ateroscleróticas à lipoproteína de baixa densidade devem considerar a quantificação direta desta a fim de abranger os indivíduos com suas diversas especificidades.


Introduction: Studies have reported a strong link between dyslipidemia and atherosclerosis. For this reason, exams such as the lipid profile are routinely performed for the prevention and monitoring of these diseases. Among the lipid indices, low density lipoproteins should be highlighted because due to their greater relation with risk factors for the development of atherosclerotic diseases. Therefore, direct methods of obtaining low density lipoproteins values, considered more accurate, are confronted with results usually obtained in the routine, through equations that provide estimated values. Objective:We compared the diagnostic methods used to obtain low density lipoproteins through the Friedewald and Martin formulas with the results obtained by automated methodology in patients attended at a University Hospital of Juiz de Fora ­ MG. MaterialandMethods: A total of 208 patients were recruited and venous blood samples were collected to obtain serum. The levels of total cholesterol, triglycerides and high density lipoprotein were quantified to obtain low density lipoproteins through the Friedewald and Martin equations. Results:A positive correlation between low density lipoproteins results has calculated by Martin and direct methods (ρ = 0.916), and positive correlation between Friedewald results and direct (ρ = 0.915). Discussion: We observed a positive correlation between the values of cholesterol and low density lipoproteins by the three methodologies. The Bland-Altman method has been used to compare the results obtained in search and methodology. Conclusion:Although the Friedewald and Martin equations have a good correlation with low density lipoproteins as measured by direct methodology, studies that relate atherosclerotic arterial diseases to low density lipoproteins should consider the direct quantification of this lipoprotein in order to cover individuals with their different specificities.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Patients , Clinical Laboratory Techniques , Diagnosis , Atherosclerosis , Hypercholesterolemia , Lipoproteins , Cholesterol, LDL
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