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Rev. méd. Chile ; 147(3): 384-389, mar. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1004361


Fibrodysplasia ossificans progressiva (FOP) or myositis ossificans, is a genetic disease, with a prevalence of 1 in 2.000.000. It is caused by pathogenic variants in ACVR1 gene and characterized by soft tissue heterotopic ossification, starting in the second decade of life. It is associated to early mortality caused by respiratory complications. It evolves in flare-ups, triggered by soft tissue injuries; therapy is symptomatic, using analgesia, steroids and diphosphonates. We report a 12-year-old female with left renal agenesis, hallux valgus and intellectual disability, presenting with a six months history of thoracic kyphosis, tender nodules in the thorax, and rigidity of right elbow and left knee. Clinical examination revealed dysmorphic facial features. A magnetic resonance showed heterotopic ossification nodules, which was confirmed with spinal radiography. These findings prompted the diagnosis of FOP. Pain treatment was started, and prednisone was used during flare-ups. The ACVR1 gene was analyzed and a pathogenic variant, p. Arg206His, was found, confirming the diagnosis of FOP.

Humans , Female , Child , Myositis Ossificans/diagnostic imaging , Prednisone/therapeutic use , Magnetic Resonance Imaging , Chile , Ossification, Heterotopic/genetics , Ossification, Heterotopic/drug therapy , Ossification, Heterotopic/diagnostic imaging , Anti-Inflammatory Agents/therapeutic use , Myositis Ossificans/genetics , Myositis Ossificans/drug therapy
Rev. cuba. ortop. traumatol ; 28(1): 109-115, ene.-jun. 2014. ilus
Article in Spanish | LILACS, CUMED | ID: lil-731998


Se presenta un paciente masculino de 49 años con antecedentes de Neoplasia de pulmón el cual acude por dolor y aumento de volumen en el miembro inferior izquierdo. Los estudios imaginológicos (radiografías, tomografía computarizada, gammagrafía) sugerían una miositis osificante del tercio medio de la diáfisis femoral izquierda, debido al compromiso de partes blandas, ya que es poco frecuente visualizarlo como una metástasis, pero el diagnóstico histopatológico fue el de una lesión metastásica(AU)

Here is the case of a 49 years-old male patient with a history of lung neoplasia that went to the doctor's because of pain and inflammation of his left leg. Imaging studies including X-rays, CT and scintigraphy indicated ossifying myositis in the medial third of the left femoral diaphysis due to compromised soft tissues, but the histopathological diagnosis showed a metastatic injure(AU)

Un patient âgé de 49 ans, avec des antécédents de néoplasie de poumon, est vu en consultation due à une douleur et à un grossissement du membre inférieur gauche. L'imagerie (radiographie, tomographie axiale informatisée, scintigraphie) a suggéré une myosite ossifiante au niveau du tiers moyen de la diaphyse fémorale gauche due à une lésion des parties molles. Puisque la métastase est difficile à distinguer, un test histologique a confirmé la lésion métastatique(AU)

Humans , Male , Middle Aged , Lung Neoplasms , Myositis Ossificans/diagnostic imaging , Neoplasm Metastasis
Maghreb Medical. 2007; 27 (386): 502-505
in French | IMEMR | ID: emr-134699


Myositis Ossificaris Circumscripta [MOC] is a rare benign disorder characterized by heterotopic ossification of soft tissues. The limbs are electively affected Spontaneons regression can occur without treatment in most patients. We report two cases of MOC. The first in a 22 yen-old male, was localised in the knee, after a period of intensive physical training with functional disorder and surgical treatment. In the second, occurring spontaneously in a 38-year-old female and interesting the triceps brachii, imaging findings were specific and we did not need histopathologic confirmation. The outcome was favourable in both patients. We report the clinical features imaging findings and therapeutic control of this pathology

Humans , Male , Female , Diffusion Magnetic Resonance Imaging , Knee , Myositis Ossificans/diagnostic imaging
JPMA-Journal of Pakistan Medical Association. 1999; 49 (9): 223-225
in English | IMEMR | ID: emr-51353
Article in English | IMSEAR | ID: sea-87385


Myositis ossificans developing as a complication of tetanus is very rare. There are only nine cases reported so far. We report here a case of a young female who developed myositis ossificans in both the elbow joints as a complication of severe tetanus.

Adult , Elbow Joint/diagnostic imaging , Female , Foot Injuries , Humans , Myositis Ossificans/diagnostic imaging , Tetanus/complications