Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 1.320
Filter
1.
Rev. cir. traumatol. buco-maxilo-fac ; 24(2): 39-44, abr.-jun. 2024. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1572579

ABSTRACT

Sialolitos são formações calcificadas, podendo se desenvolver tanto nas glândulas salivares quanto nos seus ductos, devido à retenção de materiais orgânicos e inorgânicos que constituem a saliva. Sua presença é mais frequente nas glândulas salivares maiores, sendo as salivares menores dificilmente acometidas, com prevalência em pacientes do sexo masculino, entre a terceira e quarta década de vida. O objetivo desse trabalho é relatar um caso clínico de Sialolitíase no assoalho bucal na região de carúncula sublingual tratado cirurgicamente. Paciente do sexo masculino, 26 anos, leucoderma, encaminhado à Clínica de Estomatologia da UFPB para avaliação estomatológica. Na inspeção intraoral, foi detectada uma lesão nodular de consistência endurecida e coloração branco-amarelada, localizada no assoalho bucal na região de carúncula sublingual, com crescimento endofítico, base pediculada e superfície lisa, confirmando posteriormente o diagnóstico de Sialolitíase pela análise anatomopatológica. Optou-se pela excisão cirúrgica da lesão sob anestesia local, a qual foi realizada sem intercorrências. Após 6 meses de pós-operatório, não há sinais de recidiva da lesão. A sialolitíase, embora seja a patologia mais comum das glândulas salivares, apresenta excelente prognóstico. O exame clínico, associado ao exame radiológico convencional, podem ser suficientes no diagnóstico. Quanto mais precoce for o diagnóstico, menos invasivo será o procedimento... (AU)


Sialoliths are calcified formations, which can develop both in the salivary glands and in their ducts, due to the retention of organic and inorganic materials that constitute saliva. Its presence is more frequent in the major salivary glands, the minor salivary glands being rarely affected, with a prevalence in male patients between the third and fourth decade of life. The objective of this work is to report a clinical case of sialolithiasis on the floor of the mouth in the region of the sublingual caruncle, which was surgically treated. Male patient, 26 years old, Caucasian, referred to the UFPB Stomatology Clinic for stomatological evaluation. On intraoral inspection, a nodular lesion of hardened consistency and yellowish-white color was detected, located on the buccal floor in the sublingual caruncle region, with endophytic growth, pedicled base and smooth surface, later confirming the diagnosis of sialolithiasis by anatomopathological analysis. We opted for surgical excision of the lesion under local anesthesia, which was performed uneventfully. Six months after the operation, there are no signs of recurrence of the lesion. Sialolithiasis, although it is the most common pathology of the salivary glands, has an excellent prognosis. Clinical examination, associated with conventional radiological examination, may be sufficient for the diagnosis. The earlier the diagnosis, the less invasive the procedure... (AU)


Los sialolitos son formaciones calcificadas, que pueden desarrollarse tanto en las glándulas salivales como en sus conductos, debido a la retención de materiales orgánicos e inorgánicos que constituyen la saliva. Su presencia es más frecuente en las glándulas salivales mayores, siendo raramente afectadas las glándulas salivales menores, con un pre dominio en pacientes masculinos entre la tercera y cuarta década de la vida. El objetivo de este trabajo es reportar un caso clínico de sialolitiasis en el piso de la boca en la región de la carúncula sublingual, la cual fue tratada quirúrgicamente. Paciente masculino, 26 años, caucásico, remitido a la Clínica de Estomatología de la UFPB para evaluación estomatológica. A la inspección intraoral se detectó una lesión nodular de consistencia endurecida y color blanco amarillento, ubicada en el piso de la boca en la región de la carúncula sublingual, con crecimiento endófito, base pediculada y superficie lisa, confirmándose posteriormente el diagnóstico de sialolitiasis por análisis anatomopatológico. Se optó por la exéresis quirúrgica de la lesión bajo anestesia local, que se realizó sin incidencias. Seis meses después de la operación, no hay signos de recurrencia de la lesión. La sialolitiasis, aunque es la patología más común de las glándulas salivales, tiene un excelente pronóstico. El examen clínico, asociado al examen radiológico convencional, puede ser suficiente para el diagnóstico. Cuanto más temprano sea el diagnóstico, menos invasivo será el procedimiento... (AU)


Subject(s)
Humans , Male , Adult , Salivary Glands/pathology , Salivary Gland Calculi , Mouth Floor , Mouth Mucosa/pathology
2.
J. Oral Diagn ; 9Jul. 2024. tab, ilus
Article in English | LILACS, BBO | ID: biblio-1571113

ABSTRACT

Objectives: The aim of this study was to characterize the main characteristics of this disease in relation to diagnosis, clinical aspects, progression and treatment as well as correlating them with remission time. Material and Methods: A systematic search was performed following the guidelines given by PRISMA and the Joanna Briggs Institute. PubMed, Web of Science and Scopus were the databases used. Results: The final analysis resulted in 108 articles with 173 clinical cases. The longest remission time for signs and symptoms (>7 weeks) was registered among male patients (p = 0.02) and outside the oral cavity; however no significant correlation was observed (p>0.05). A high risk of bias was the most common rating among the articles analyzed (55%); followed by moderate (27%) and low (18%). The lack of standardization in clinical case report descriptions made it difficult to gain a thorough knowledge of the essential characteristics of the NS patho-logical processes. Conclusion: It is recommended that publications follow the standards recommended by the literature; in addition, studies using advanced technologies to better understand NS's pathological path are recommended so as to propose effective treatments for this disease. (AU)


Subject(s)
Humans , Salivary Glands , Sialometaplasia, Necrotizing , Evidence-Based Dentistry , Pathology, Oral , Diagnosis
3.
J. Oral Diagn ; 9: e259, Jul. 2024. tab, ilus
Article in English | LILACS, BBO | ID: biblio-1584913

ABSTRACT

Objective: To evaluate the clinicopathological and immunohistochemical features of an original series of canalicular adenoma. Methods: Cases diagnosed as canalicular adenoma from a single center were retrospectively retrieved and clinical data collected from patients' charts. The histopathological features of all cases were reviewed and a large immunohistochemical panel carried out. Results: Eleven cases were collected, and no gender predilection was seen. A painless upper lip nodule was the most frequent clinical presentation. All cases presented the single-layer epithelial arrangement of tumor cells in a loose stroma. It was found an increased expression of low-weight cytokeratins, absence of myogenic markers, variable positivity for vimentin, S100 and GFAP, cytoplasmic and membrane reactivity for ß-catenin and a strong CD34 positivity, whereas no lymphatic vessel was identified using D2-40 antibody. Conclusion: Canalicular adenoma is composed of luminal epithelium with strong expression of low-weight cytokeratins, and peripheral expression of ß-catenin may be involved in the architectural maintenance of the tumor. (AU)


Subject(s)
Humans , Pathology, Clinical , Immunohistochemistry , Adenoma , Salivary Glands , Neoplasms
4.
Braz. j. oral sci ; 23: e243908, 2024. ilus
Article in English | LILACS, BBO | ID: biblio-1553393

ABSTRACT

Aim: To carry out a retrospective analysis of the frequency and severity of clinical signs of radioiodine (131I)-induced damage to the salivary glands in the early and long-term post-radiation periods, and identify risk factors for their occurrence in patients with differentiated thyroid carcinomas. Methods: A total of 330 patients underwent thyroidectomy with dissection of lymphatic nodes. One month after surgery, all the patients received radioiodine therapy. The dose and number of courses varied depending on the stage and morphological type of the tumor. In the late post-radiation period, the patients were surveyed with the use of a standard questionnaire, which allowed retrospective assessment of the nature and severity of symptoms of radiationinduced damage, as well as the time of their onset/subsidence. Results: Radiation-induced sialoadenitis of the salivary glands was observed in 51.2% of patients treated with 131I. The main symptoms included pain and discomfort in the salivary glands (51.2% of patients), swelling (48.8%), transient or permanent dry mouth (38%), and distortion of taste (38%). There were statistically significant correlations between the presence and severity of the main clinical symptoms of salivary gland irradiation. A significant relationship (r = 0.91, p < 0.001) was found between swelling of the salivary glands and the feeling of pain or discomfort, which was indicative of inflammation and retention of saliva. Conclusion: The main factors influencing the formation of chronic radiation-induced sialoadenitis and the severity of the inflammatory process included the tumor stage, the total dose of radiopharmaceuticals, and the duration following radioiodine therapy


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Radiotherapy , Salivary Glands , Xerostomia , Thyroid Neoplasms , Thyroidectomy , Lymph Nodes
5.
Rev. Cient. CRO-RJ (Online) ; 8(3): 94-98, 2024.
Article in Portuguese | LILACS, BBO | ID: biblio-1581377

ABSTRACT

Introdução: o adenoma pleomórfico (AP) é uma neoplasia benigna que afeta as glândulas salivares e que apresenta notável variedade histopatológica. Objetivo: Relatar o caso de um AP com apresentação clínica atípica em lábio superior. Relato do caso: uma mulher de 88 anos buscou atendimento estomatológico queixando-se de aumento de volume em lábio superior, assintomático, com tempo de evolução de 2 anos. O exame físico mostrou aumento de volume de limites mal definidos, base séssil, com áreas normocrômicas e avermelhadas, telangiectasias, superfície ulcerada, em mucosa labial superior e fundo de vestíbulo do lado esquerdo, além de notável assimetria facial. Com hipótese diagnóstica de neoplasia maligna de glândula salivar, uma biópsia incisional foi realizada. Microscopicamente, observou-se neoplasia glandular composta por células epitelial ductais e células mioepiteliais com múltiplas formações ductais, presente em um estroma frouxo e cartilagíneo. A tomografia computadorizada evidenciou uma lesão ampla e extensa com densidade compatível com tecidos moles, sem focos de calcificação ou comprometimento de estruturas ósseas. Com base nos critérios clínicos, imagenológicos e histopatológicos, o diagnóstico final foi de AP. A paciente foi submetida à exérese total da lesão em ambiente hospitalar. O pós-operatório de 06 meses revelou ausência de recidiva da lesão e melhora significativa no aspecto facial. Conclusão: o AP deve ser considerado como hipótese diagnóstica para aumentos de volume de crescimento lento em lábio superior, ainda que apresentem áreas ulceradas e telangiectásicas.


Introduction: pleomorphic adenoma (PA) is a benign neoplasm that affects the salivary glands and presents remarkable histopathological variety. Objective: to report the case of a PA with atypical clinical presentation in the upper lip. Case report: an 88-year-old woman sought dental care complaining of an asymptomatic swelling in her upper lip, which had been evolving for 2 years. The physical examination showed a swelling of ill-defined limits, sessile, with normochromic and reddish areas, telangiectasias, an ulcerated surface, in the upper labial mucosa and the vestibule on the left side, in addition to notable facial asymmetry. With diagnostic hypothesis of salivary gland malignancy, an incisional biopsy was performed. Microscopically, a glandular neoplasm composed of ductal epithelial cells and myoepithelial cells with multiple ductal formations was observed, present in a loose and cartilaginous stroma. Computed tomography showed a large and extensive lesion with a density compatible with soft tissues, without foci of calcification or involvement of bone structures. Based on clinical, imaging and histopathological criteria, the final diagnosis was PA. The patient underwent total excision of the lesion in a hospital setting. The 6-month postoperative evaluation showed no recurrence of the lesion and significant improvement in facial appearance. Conclusion: PA should be considered as a diagnostic hypothesis for slowly growing swellings in the upper lip, even if they present ulcerated and telangiectatic areas.


Subject(s)
Female , Aged, 80 and over , Adenoma, Pleomorphic/diagnosis , Salivary Glands , Mouth Neoplasms , Lip
6.
Belo Horizonte; s.n; 2024. 98 p. ilus.
Thesis in Portuguese | LILACS, BBO | ID: biblio-1566609

ABSTRACT

Os subtipos de linfomas não Hodgkin representam 2,8% de todos os novos casos de câncer no mundo, sendo o terceiro grupo mais comum de neoplasias malignas da região de cabeça e pescoço. As glândulas salivares maiores representam o terceiro sítio extranodal mais acometido pelo linfoma na região da cabeça e pescoço; entretanto, nas glândulas salivares maiores é muito raro, representando aproximadamente 1,7­3,1% de todas as neoplasias das glândulas salivares, acometendo a maioria dos casos as glândulas parótidas (79%), seguidas pelas glândulas submandibulares (18%) e sublinguais (1%). Os subtipos mais comuns são linfoma do tecido linfoide associado à mucosa (MALT), o linfoma folicular (FL) e o linfoma difuso de grandes células B (DLBCL), e a frequência destas neoplasias está associado com a ocorrência simultânea de condições sistêmicas que predispõem ao desenvolvimento de neoplasias linfoides como a Síndrome de Sjögren (SS). Entretanto, a literatura sobre linfomas em glândulas maiores permanece muito escassa e impede que conheçamos de forma apropriada as características destes pacientes. Assim, o objetivo deste estudo é avaliar as manifestações clínicas e microscópicas dos linfomas em glândulas salivares maiores. Para isto, foram recuperados de forma retrospectiva dos arquivos de patologia de algumas instituições todos os casos diagnosticados como linfomas acometendo estes sítios anatômicos. Foram coletados os dados clínicos referentes ao sexo, idade, localização, apresentação clínica, tempo de evolução, status, estadiamento e ocorrência da SS, e as informações histopalógicas foram coletadas de blocos de parafina e lâminas em hematoxilina e eosina e imuno-histoquímicas acessíveis. Os resultados obtidos foram avaliados de forma descritiva. As séries compreenderam de 7 casos de linfomas em glândula sublingual, 16 casos em glândula submandibular e 12 casos em glândula parótida. Clinicamente, os linfomas apresentam-se como aumento de volume assintomático, sendo os subtipos mais frequentes os de células B maduras de baixo grau (MALT, FL, MCL), mas subtipos de alto grau também foram observados (LDGCB, SOE). Dois pacientes, um de linfoma de células do manto (LCM) e outro de LDGCB,SOE em glândula sublingual apresentaram como doença disseminada, e apenas três casos de linfoma MALT em glândula parótida apresentam a SS. O tratamento dependeu do microscópico e estágio do tumor, variando de cirurgia, regimes quimioterápicos com R-CHOP e radioterapia. O prognóstico foi favorável principalmente para os casos de baixo grau (MALT,FL), e apenas dois pacientes de sublingual (LDGCB,SOE, MCL) e três de submandibular (LDGCB,SOE, linfoma plasmablastico e MALT) faleceram após o diagnóstico. Neste estudo concluímos que os linfomas em glândulas salivares maiores são afetados principalmente por neoplasias de células B maduras de baixo grau (MALT, FL, MCL) e esses pacientes devem passar por uma avaliação sistêmica criteriosa para determinar se a doença se trata de uma neoplasia primária ou disseminada.


Non-Hodgkin's lymphomas account for 2.8% of all new cancer cases worldwide and are the third most common group of malignant neoplasms in the head and neck region. The major salivary glands represent the third most common extranodal site affected by lymphoma in the head and neck region; however, in the major salivary glands it is very rare, representing approximately 1.7-3.1% of all salivary gland neoplasms, affecting most cases in the parotid glands (79%), followed by the submandibular glands (18%) and sublingual glands (1%). The most common subtypes are mucosa- associated lymphoid tissue lymphoma (MALT), follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL), and the frequency of these neoplasms is associated with the simultaneous occurrence of systemic conditions that predispose to the development of lymphoid neoplasms such as Sjögren's Syndrome(SS). However, the literature on lymphomas in major glands remains very scarce and prevents us from properly understanding the characteristics of these patients. Therefore, the aim of this study was to evaluate the clinical and microscopic manifestations of lymphomas in the major salivary glands. To this end, all cases diagnosed as lymphomas affecting these anatomical sites were retrospectively retrieved from the pathology archives of a number of institutions. Clinical data was collected on gender, age, location, clinical presentation, time of evolution, status, staging and occurrence of SS, and histopathological information was collected from paraffin blocks and slides in hematoxylin and eosin and accessible immunohistochemistry. The results obtained were evaluated descriptively. The series comprised 7 cases of lymphomas in the sublingual gland, 16 cases in the submandibular gland and 12 cases in the parotid gland. Clinically, the lymphomas presented as asymptomatic enlargement, with the most frequent subtypes being low-grade mature B-cells (MALT, FL, MCL), but high- grade subtypes were also observed (LDGCB, SOE). Two patients, one with mantle cell lymphoma (MCL) and the other with LDGCB,SOE in the sublingual gland presented with disseminated disease, and only three cases of MALT lymphoma in the parotid gland presented with SS. Treatment depended on the microscopic subtype and stage of the tumor, ranging from surgery to chemotherapy regimens with R-CHOP and radiotherapy. Prognosis was mainly favorable for low-grade cases (MALT,FL), and only two sublingual patients (LDGCB,SOE, MCL) and three submandibular patients (LDGCB,SOE, plasmablastic lymphoma and MALT) died after diagnosis. In this study we conclude that lymphomas in the major salivary glands are mainly affected by low- grade mature B-cell neoplasms (MALT, FL, MCL) and these patients should undergo a careful systemic evaluation to determine whether the disease is a primary or disseminated neoplasm.


Subject(s)
Parotid Gland , Salivary Glands , Sublingual Gland , Submandibular Gland , Lymphoma
7.
Rev. Fac. Odontol. (B.Aires) ; 39(91): 67-85, 2024. ilus
Article in Spanish | LILACS | ID: biblio-1555113

ABSTRACT

Muchas investigaciones se han ocupado de evaluar la vinculación entre las afecciones bucales y otras funciones o afecciones del organismo. Algunos de esos estudios han sentado precedentes acerca de la influencia mutua que puede existir entre la fun-cionalidad de las glándulas salivales y la enfermedad periodontal, y cómo la presencia de una condición puede modificar la evolución o inducir la aparición de la otra. El objetivo del presente trabajo es hacer una revisión bibliográfica de las publicaciones cientí-ficas que evalúan los efectos de inducción recíproca que existe entre la enfermedad periodontal y la hi-posalivación. Trabajos de nuestro grupo y de otros autores demuestran que la hiposalivación reduce la capacidad del organismo para defenderse contra las bacterias patógenas, mantener un ambiente sa-ludable y facilitar la cicatrización en la cavidad bu-cal, promoviendo los procesos de inflamación y daño tisular gingivoperiodontal. A su vez, varios estudios reportan que la enfermedad periodontal induce cam-bios en las glándulas salivales y altera el volumen de secreción salival. Por su parte, el sistema endo-cannabinoide (SEC) muestra estar involucrado tanto en el proceso de secreción salival como en la infla-mación y la reabsorción ósea presentes en la enfer-medad periodontal, en tanto que la activación de los mecanismos del SEC emerge como una de las vías a través de las cuales se desarrollaría el fenómeno de inducción recíproca (AU)


Many investigations have focused on evaluating the link between oral conditions and other functions or conditions of the body. Some of these studies have set precedents about the mutual influence that may exist between the functionality of the salivary glands and periodontal disease, and how the presence of one condition can modify the evolution or induce the appearance of the other. The objective of this work is to carry out a bibliographic review of scientific publications that evaluate the reciprocal induction effects that exist between periodontal disease and hyposalivation. Studies by our group and other authors show that hyposalivation reduces the capacity of the organism to defend itself against pathogenic bacteria, maintain a healthy environment and facilitate healing in the oral cavity, promoting inflammation and gingivoperiodontal tissue damage. In turn, several studies report that periodontal disease induces changes in the salivary glands and alters the volume of salivary secretion. In turn, the endocannabinoid system (ECS) is shown to be involved in the salivary secretion process as well as in the inflammation and bone resorption present in periodontal disease, while the activation of ECS mechanisms emerges as one of the pathways through which the reciprocal induction phenomenon would develop (AU)


Subject(s)
Humans , Periodontitis/etiology , Xerostomia/etiology , Endocannabinoids , Salivary Glands/physiopathology , Oxidative Stress/physiology , Neuroinflammatory Diseases/physiopathology , Inflammation/physiopathology
8.
Acta cir. bras ; Acta Cir. Bras. (Online);39: e390824, 2024. tab, graf, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1533356

ABSTRACT

Purpose: This systematic review analyzed the clinical behavior and odds of malignancy of the palatal recurrent pleomorphic adenomas. Methods: Systematic review of patients with recurrent pleomorphic adenoma arising in the palate. Database search: MEDLINE, Scopus, Web of Science, Cochrane, EMBASE, Virtual Health Library, Google Scholar, and OpenGrey. A binomial logistic regression was performed to assess the odds of detecting recurrence five, 10 and 20 years after the treatment of primary tumor. Results: Thirteen studies (n = 18 patients) out of 336 were included. The recurrent pleomorphic adenoma in palate was more common in females (61.6%), average age was 49 years old (range 9-73 years old). Four patients progressed to malignant transformation. The odds ratio (OR) of detecting a recurrence at 10 (OR = 5.57; 95% confidence interval - 95%CI 1.13-27.52), and 20 years (OR = 18.78; 95%CI 3.18-110.84) after treatment of primary pleomorphic adenoma was significantly higher than at one-year follow-up. Conclusions: The recurrence of pleomorphic adenoma in palate remains a rare event of late occurrence. It mainly affects middle-aged female and carries a risk of malignant transformation. Although uncommon, patients with palatal pleomorphic adenoma should be warned about the possibility of recurrence or malignant transformation of tumor at advanced ages.


Subject(s)
Palate , Salivary Glands , Adenoma, Pleomorphic , Neoplasms
9.
Int. j. morphol ; 41(5): 1364-1371, oct. 2023. ilus
Article in English | LILACS | ID: biblio-1521035

ABSTRACT

SUMMARY: The salivary glands in pathological conditions produce countless different clinical presentations, and due to their complex neuroanatomy, their pain symptoms vary widely. However, in the literature to date, few studies characterize salivary gland pain. The aim of this study was to conduct a literature review concerning the clinical characteristics of pain in various salivary gland pathologies. A literature review was done through a systematic search of scientific articles in the Web of Science (WoS), MEDLINE, Scopus, and Elton B. Stephens Company (EBSCO) databases. The free terms "salivary gland", "parotid gland", "submaxillary gland", "sublingual gland", and "pain" were used along with the Boolean operators OR and AND. The search yielded a total of 1896 articles, of which 60 fulfilled the inclusion criteria and were ultimately included in this review. It is described that pain is a nonspecific symptom of a glandular pathology and is characterized mainly by the location of the pain, which is correlated with the anatomical location of the affected salivary gland. Among the painful salivary gland pathologies, we found inflammatory disorders, including infections, obstructions, disorders secondary to hyposalivation; systemic autoimmune diseases; neoplasms, and neuropathic pain disorders. The diagnosis and management of salivary gland pain require knowledge of the causes and mechanisms of the pain, and it is to recognize the signs and symptoms of salivary gland disorders to be able to diagnose and treat them.


Las glándulas salivales en condiciones patológicas producen un sinfín de presentaciones clínicas diferentes, y debido a su compleja neuroanatomía generan variaciones en su sintomatología dolorosa. Sin embargo, en la literatura hasta ahora son escasos los estudios que caracterizan el dolor de glándulas salivales. El objetivo de este estudio fue realizar una revisión de la literatura respecto a las características clínicas del dolor en diversas patologías de glándulas salivales. Se realizó una revisión de la literatura, a través de la búsqueda sistemática de artículos científicos en las bases de datos Web of Science (WoS), MEDLINE, Scopus y Elton B. Stephens Company (EBSCO). A través de los términos libres: "salivary gland", "parotid gland", "submaxillary gland", "sublingual gland", "pain", junto con los operadores booleanos OR y AND. La búsqueda arrojó un total de 1896 artículos, de los cuales 60 cumplieron los criterios de inclusión y fueron finalmente incluidos en esta revisión. Se describe que el dolor es un síntoma poco específico para la patología glandular y está caracterizado principalmente por la localización del dolor, el cual se correlaciona con la ubicación anatómica de la glándula salival afectada. Dentro de las patologías dolorosas de glándulas salivales encontramos los trastornos inflamatorios, incluidas infecciones, obstrucciones, trastornos secundarios a hiposalivación; enfermedades sistémicas autoinmunes; neoplasias y trastornos de dolor neuropático. El diagnóstico y manejo del dolor de glándulas salivales requiere del conocimiento de las causas y mecanismos del dolor, siendo necesario reconocer los signos y síntomas de los trastornos de glándulas salivales para ser capaces de diagnosticarlos y tratarlos.


Subject(s)
Humans , Salivary Gland Diseases/pathology , Salivary Glands/pathology , Facial Pain
10.
Rev. otorrinolaringol. cir. cabeza cuello ; 83(2): 141-149, jun. 2023. tab, ilus
Article in Spanish | LILACS | ID: biblio-1515472

ABSTRACT

Introducción: La sialorrea es la pérdida involuntaria de saliva de la boca, ya sea debido a la producción excesiva de saliva o disminución de la frecuencia de deglución. Se habla de sialorrea patológica cuando persiste más allá de los 4 años de edad. Además de las implicaciones sociales, cambios de ropa frecuentes, puede provocar neumonías por aspiración y deshidratación. El manejo de la sialorrea requiere una evaluación completa con un enfoque de equipo multidisciplinario para el tratamiento, que incluye terapias no farmacológicas, farmacológicas y quirúrgicas. Objetivo: Presentar resultados quirúrgicos y farmacológicos en el tratamiento de sialorrea masiva. Material y Método: Se realizó revisión de historias clínicas de 7 pacientes portadores de sialorrea masiva. Todos los pacientes incluidos fueron refractarios a tratamiento médico. El diagnóstico fue obtenido por un equipo multidisciplinario. Se les realizó desfuncionalización quirúrgica y farmacológica de glándulas salivales. Se les aplicó Escala de Severidad (DSS) y escala de frecuencia (DFS), previo a cirugía y posterior a procedimiento hasta el año. Resultados: Mejoría clínica subjetiva posterior a desfuncionalización quirúrgica con disminución de DSS y DFS. Disminución promedio de baberos a 10/día. Conclusión: Los resultados obtenidos son buenos, si se consideran las escalas DSS, DFS y el número de baberos al día, que son mediciones tanto subjetivas y objetivas respectivamente.


Introduction: Massive Sialorrhea is the involuntary loss of saliva from the mouth, either due to excessive saliva production or decreased swallowing frequency. We speak of pathological sialorrhea when it persists beyond 4 years old. In addition to the social implications and frequent clothing changes. It can cause aspiration pneumonia and dehydration. Treatment for sialorrhea requires a comprehensive evaluation with a multidisciplinary team approach. Including non-pharmacological, pharmacological, and surgical therapies. Aim: Presentation of the results of surgical defunctionalization of the salivary glands plus injection of Botulinum Toxin in the treatment of massive sialorrhea. Material and Method: A review of the clinical records of 7 patients with massive sialorrhea was carried out. All included patients were refractory to medical treatment. The diagnosis was obtained by a multidisciplinary team. Surgical and pharmacological dysfunctionalization of salivary glands was performed. Severity Scale (DSS) and Frequency Scale (DFS) were applied before surgery and after the procedure up to a year. Results: Subjective clinical improvement after surgical defunctionalization with decreased SHD and DFS. Average decrease in bibs to 10/day. Conclusion: The evaluated strategy presented similar benefits with respect to the literature. The SHD and DFS scales and the number of bibs per day are both subjective and objective measurements, respectively, and allow the clinical improvement and quality of life of patients undergoing surgery to be evaluated individually.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Salivary Glands/surgery , Sialorrhea/surgery , Sialorrhea/drug therapy , Severity of Illness Index , Epidemiology, Descriptive , Treatment Outcome , Botulinum Toxins, Type A/therapeutic use
12.
J. Oral Diagn ; 8: e20230219, 01 out. 2023. ilus
Article in English | LILACS | ID: biblio-1572197

ABSTRACT

Objective: To report a case of pleomorphic adenoma that was surgically removed and to describe the surgical technique available to remove this lesion. Case Report: A male patient, caucasian, 46 years old, with a 4-year history of pleomorphic adenoma. He mentioned that he went to other services for treatment, but without success. He came at our service for treatment with tumoral excision. Local anesthesia was performed with mepivacaine with a vasoconstrictor and tumoral excision was performed with the overlying mucosa and the periosteal region to avoid recurrence. The patient has been under postoperative follow-up for two years without recurrence. Conclusion: Pleomorphic adenoma is a benign tumor and presents as a submucosal mass of slow growth. The ideal treatment for the Pleomorphic Adenoma tumor is the total excision of the lesion with the removal of the mucosa covering the region to avoid recurrence. (AU)


Subject(s)
Humans , Male , Middle Aged , Adenoma, Pleomorphic , Palate, Hard , Diagnostic Techniques, Surgical , Salivary Glands , Neoplasms
13.
Article in English | WPRIM | ID: wpr-981106

ABSTRACT

OBJECTIVES@#This study aims to investigate the effects of tumor-stromal fibroblasts (TSFs) on the proliferation, invasion, and migration of salivary gland pleomorphic adenoma (SPA) cells in vitro.@*METHODS@#Salivary gland pleomorphic adenoma cells (SPACs), TSFs, and peri-tumorous normal fibroblasts (NFs) were obtained by tissue primary culture and identified by immunocytochemical staining. The conditioned medium was obtained from TSF and NF in logarithmic phase. SPACs were cultured by conditioned medium and treated by TSF (group TSF-SPAC) and NF (group NF-SPAC). SPACs were used as the control group. The proliferation, invasion, and migration of the three groups of cells were detected by MTT, transwell, and scratch assays, respectively. The expression of vascular endothelial growth factor (VEGF) in the three groups was tested by enzyme linked immunosorbent assay (ELISA).@*RESULTS@#Immunocytochemical staining showed positive vimentin expression in NF and TSF. Results also indicated the weak positive expression of α-smooth muscle actin (SMA) and fibroblast activation protein (FAP) in TSFs and the negative expression of α-SMA and FAP in NFs. MTT assay showed that cell proliferation in the TSF-SPAC group was significantly different from that in the NF-SPAC and SPAC groups (P<0.05). Cell proliferation was not different between the NF-SPAC and SPAC groups (P>0.05). Transwell and scratch assays showed no difference in cell invasion and migration among the groups (P>0.05). ELISA showed that no significant difference in VEGF expression among the three groups (P>0.05).@*CONCLUSIONS@#TSFs may be involved in SPA biological behavior by promoting the proliferation of SPACs but has no effect on the invasion and migration of SPACs in vitro. Hence, TSF may be a new therapeutic target in SPA treatment.


Subject(s)
Humans , Adenoma, Pleomorphic/metabolism , Vascular Endothelial Growth Factor A , Culture Media, Conditioned/metabolism , Fibroblasts/metabolism , Salivary Glands/metabolism
14.
Article in English | WPRIM | ID: wpr-1007918

ABSTRACT

More than 30 years of rapid development of endoscopic surgery has led to the mainstreaming of this procedure in many surgical departments in China. Since the first report on endoscopy, it has been used in salivary gland resection for more than 20 years. The overall development of endoscopic surgery indicates that its use in oral and maxillofacial surgery is still in the early exploration stage; it has not yet been maturely developed or applied. Owing to the advancement of other disciplines and corresponding widening experiences in those fields, the development of endoscopic technology in oral and maxillofacial surgery will likely achieve a leapfrogging. Learning from the general development pattern of endoscopy, this research explores the application history, current situation, and future direction of the application of endoscopy in salivary gland surgery.


Subject(s)
Endoscopy/methods , Endoscopes , Salivary Glands/surgery , China
15.
Article in English | WPRIM | ID: wpr-982474

ABSTRACT

Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical manifestation that has the potential to cause severe oral and/or systemic diseases and compromise quality of life. Currently, the standard-of-care for this condition remains palliative. A variety of approaches have been employed to restore saliva production, but they have largely failed due to damage to both secretory cells and the extracellular matrix (niche). Transplantation of allogeneic cells from healthy donors has been suggested as a potential solution, but no definitive population of SG stem cells, capable of regenerating the gland, has been identified. Alternatively, mesenchymal stem cells (MSCs) are abundant, well characterized, and during SG development/homeostasis engage in signaling crosstalk with the SG epithelium. Further, the trans-differentiation potential of these cells and their ability to regenerate SG tissues have been demonstrated. However, recent findings suggest that the "immuno-privileged" status of allogeneic adult MSCs may not reflect their status post-transplantation. In contrast, autologous MSCs can be recovered from healthy tissues and do not present a challenge to the recipient's immune system. With recent advances in our ability to expand MSCs in vitro on tissue-specific matrices, autologous MSCs may offer a new therapeutic paradigm for restoration of SG function.


Subject(s)
Mesenchymal Stem Cell Transplantation , Mesenchymal Stem Cells , Quality of Life , Regeneration , Salivary Glands , Stem Cells
16.
Mastology (Online) ; 332023. ilus
Article in English | LILACS | ID: biblio-1433878

ABSTRACT

Breast cancer is a heterogeneous disease with various histological and molecular subtypes. Among them, salivary gland tumors are rare and can be divided into three groups: pure myoepithelial differentiation, pure epithelial differentiation and myoepithelial with mixed epithelial differentiation. In the last group, adenoid cystic carcinoma stands out, a rare entity with low malignant potential. It represents less than 0.1­3% of breast cancer cases and has the most frequent clinical presentation as a palpable mass. The diagnosis is confirmed by histology and immunohistochemistry. Classically, they are low-aggressive triple-negative tumors, with overall survival and specific cancer survival at five and ten years greater than 95%. However, there are rare reports of aggressive variants with a risk of distant metastasis and death. Treatment is based on surgical resection with margins. Lymphatic dissemination is rare, and there is no consensus regarding the indication of an axillary approach. Adjuvant radiotherapy is indicated in cases of conservative surgery and should be discussed in other cases. The benefit of chemotherapy remains uncertain, as most tumors are indolent. We report a case that required individualized decisions based on its peculiarities of presentation, diagnosed in an asymptomatic elderly patient during screening, in which mammography showed heterogeneous gross calcifications clustered covering 1.6 cm. Stereotacticguided vacuum-assisted biopsy was performed, and the area was marked with a clip. The anatomopathological examination led to a diagnosis of salivary gland-type carcinoma, triple-negative. The patient underwent segmental resection of the right breast and sentinel lymph node biopsy. The final anatomopathological result was similar to that of the biopsy, with an immunohistochemicalprofile of the adenoid cystic type and two sentinel lymph nodes free of neoplasia. Considering age and histological subtype, adjuvant therapy was not indicated. Follow-up for three years showed no evidence of disease


Subject(s)
Humans , Female , Aged , Salivary Glands/pathology , Carcinoma/diagnosis , Triple Negative Breast Neoplasms/diagnosis , Carcinoma/surgery , Triple Negative Breast Neoplasms/surgery
17.
Rev. int. Coll. Odonto-Stomatol. Afr. Chir. Maxillo-Fac ; 30(3): 36-40, 2023. figures, tables
Article in French | AIM | ID: biblio-1511288

ABSTRACT

Introduction : l'adénome pléomorphe est le type histologique le plus fréquemment observé des tumeurs bénignes des glandes salivaires accessoires (GSA). L'objectif de cette étude était de décrire les particularités épidémiologiques, diagnostiques et thérapeutiques des tumeurs bénignes des GSA. Matériel et méthodes : Il s'est agi d'une étude transversale à collecte rétrospective descriptive réalisée dans le service de Stomatologie et Chirurgie MaxilloFaciale du CHU de Bouaké, sur une période de 8 ans (1er Janvier 2015 au 31 Décembre 2022). Résultats : 18 dossiers de patients dont 12 femmes et 6 hommes, opérés pour une tumeur bénigne des GSA, ont été colligés. L'âge médian des patients était de 37 ans avec des extrêmes de 35 et 62 ans. Le siège de prédilection était le palais dans 12 cas, les lèvres dans 3 cas, la joue dans 2 cas et la langue dans 1 cas. La tomodensitométrie maxillo-faciale a été l'examen de choix pour l'orientation diagnostique. Le traitement a consisté en une exérèse en mono bloc sous anesthésie générale par voie endo buccale. L'examen anatomopathologique a confirmé le diagnostic d'un adénome pléomorphe dans tous les cas. Après un recul de 2 ans, aucune récidive n'a été observée. Discussion : L'adénome pléomorphe représente le type histologique le plus fréquent des tumeurs bénignes des GSA. Il atteint avec prédilection l'adulte jeune de sexe féminin et siège au palais. L'exérèse chirurgicale reste le traitement de choix.


Introduction: Pleomorphic adenoma is the most frequently observed histological type of benign tumour of the accessory salivary glands (ASG). The aim of this study was to describe the epidemiological, diagnostic and therapeutic features of ASGs. Material and methods: This was a retrospective descriptive study conducted in the Stomatology and Maxillofacial Surgery Department of the Bouaké University Hospital, over an 8-year period (January 1, 2015 to December 31, 2022). Results: A total of 18 patients (12 women and 6 men) underwent surgery for benign tumours of the GSA. The median age of the patients was 37 years, with extremes of 35 and 62 years. The preferred site was the palate in 12 cases, the lips in 3 cases, the cheek in 2 cases and the tongue in 1 case. Maxillofacial computed tomography has been the examination of choice for diagnostic orientation. Treatment consisted of single-block excision under general anaesthetic via the endo-buccal route. Pathological examination confirmed the diagnosis of a pleomorphic adenoma in all cases. After a 2-year follow-up, no recurrence was observed. Discussion: Pleomorphic adenoma is the most common histological type of benign tumour of the GSA. It prefers to affect young adult women and is located on the palate. Surgical excision remains the treatment of choice


Subject(s)
Salivary Glands , Adenoma , Epidemiology , Diagnosis
18.
Int. j. odontostomatol. (Print) ; 16(4): 475-482, dic. 2022. graf, tab
Article in Spanish | LILACS | ID: biblio-1421842

ABSTRACT

El síndrome de Sjögren es la segunda enfermedad autoinmune crónica más prevalente; factores hereditarios y medioambientales interactúan provocando una "epitelitis autoinmune" que daña el tejido glandular exocrino principalmente, pero también a otros órganos; debido a esta heterogeneidad clínica, el diagnóstico y tratamiento constituyen un desafío. Estudios demuestran que afecta al 0,1-0,6 % de la población, con predilección por el sexo femenino (9:1). En Colombia existen pocos estudios epidemiológicos descriptivos y de caracterización en este síndrome. Caracterizar los parámetros clínicos y epidemiológicos de pacientes con síndrome de Sjögren. Se realizó un estudio observacional descriptivo de corte transversal, se revisaron historias clínicas de 409 pacientes con el síndrome que asistieron al Hospital Universitario San Ignacio entre 2012 y 2019. Los datos se analizaron usando estadística descriptiva. La edad promedio de diagnóstico fue 59 años, la relación mujer: hombre 9:1, (91,7 % y 8,3 % respectivamente). Hubo mayor prevalencia en pacientes de 51 a 60 años (131) seguido por los de 61-70 años (114). La manifestación clínica más común fue la xerostomía (90 %); la biopsia de glándula salival menor fue el examen complementario más solicitado (65 %). El compromiso óseo-articular, fue la enfermedad concomitante más asociada. La etiología de la enfermedad es poco conocida, sin embargo, su caracterización, así como la identificación de medios diagnósticos y terapéuticos ayuda en la comprensión de la clínica; dicha información permitirá el desarrollo de tratamientos cada vez más efectivos y específicos.


Sjögren syndrome is the second most common chronic autoimmune disease, environmental and hereditary mechanisms causes an autoimmune epithelitis that affect the exocrine glandular tissue mainly, but also other organs; because this broad spectrum of clinical characteristics, the diagnostic and treatment become a challenge. Studies has shown that 0.1-0.6 % of the population is affected, with predominance of females over males (9:1). In Colombia there are few descriptive epidemiological studies and characterization of the affected population. Clinical and epidemiological characterization of Sjögren syndrome patients. A descriptive cross-sectional observational study was conducted, 409 clinical histories of patients with the syndrome at San Ignacio University Hospital from 2012 to 2019 were analized. The data collected were subjected to a descriptive statistic. The average age of diagnosis was 59 years, the ratio female: male 9:1 (91.7 % and 8.3 % respectively), the highest frequency of the syndrome was found in the 51 to 60 years old group (131) followed by the 61 to 70 years old group (114). The most common clinical manifestation was xerostomia (90 %), minor salivary gland biopsy was the most frequent test requested (65 %). The osseoarticular involvement was the most frecuent concomitant disease. Although the etiology of Sjögren syndrome is little known, its characterization, as well as the identification of the diagnostic and therapeutic means used, is of great help in understanding the disease; this information will allow the development of increasingly effective and specific treatments. More studies are required, in different locations, which will highlight the differences between populations.


Subject(s)
Humans , Male , Female , Middle Aged , Sjogren's Syndrome/diagnosis , Sjogren's Syndrome/etiology , Salivary Glands , Xerostomia , Biopsy , Sjogren's Syndrome/epidemiology , Epidemiology, Descriptive , Prevalence , Risk Factors
19.
Med. UIS ; 35(3)dic. 2022.
Article in Spanish | LILACS | ID: biblio-1534816

ABSTRACT

El síndrome de Sjögren es un trastorno crónico autoinmune que afecta a las glándulas secretoras, principalmente salivales y lagrimales; además, puede presentar manifestaciones sistémicas extraglandulares. El objetivo de esta revisión fue revisar la literatura sobre los aspectos generales del síndrome de Sjögren, para lo cual se realizó una búsqueda en bases de datos entre el 15 de enero y el 15 de marzo del 2020, en donde se obtuvieron 29 artículos sobre los cuales se hizo la revisión. El síndrome de Sjögren tiene una importante prevalencia entre las enfermedades autoinmunes más comunes, caracterizada por presentar xerostomía y xeroftalmia. Los criterios diagnósticos tienen alta sensibilidad y especificidad y su tratamiento es sintomático.


Sjögren's syndrome is a chronic autoimmune disorder that affects the secretory glands, mainly salivary and lacrimal glands; and also can present extraglandular systemic manifestations. The objective of this review was to check the literature about the general aspects of Sjorgen's syndrome, for which a search of the literature was carried out between January 15 to March 15, 2020, 29 articles were obtained on which did the review. Sjögren's syndrome is highly prevalent among the most common autoimmune diseases, characterized by xerostomia and xerophthalmia. The diagnostic criteria have high sensitivity and specificity, and their treatment is symptomatic.


Subject(s)
Humans , Salivary Glands , Sjogren's Syndrome , Autoimmunity , Lymphocytes , Keratoconjunctivitis Sicca
20.
Rev. colomb. cir ; 37(4): 574-579, 20220906. fig, tab
Article in Spanish | LILACS | ID: biblio-1396340

ABSTRACT

Introducción. La sialoendoscopia es un procedimiento cuya finalidad es visualizar los conductos salivales. Se utiliza como método diagnóstico y terapéutico de procesos inflamatorios, estenosis de los conductos y procesos obstructivos. Métodos. Describir los procedimientos realizados para el tratamiento de pacientes con patología inflamatoria y obstructiva de las glándulas salivales, de forma única con sialoendoscopia o con abordajes mixtos. Resultados. Un total de 24 pacientes fueron incluidos en el estudio, con edad promedio de 42 años, en su mayoría mujeres y compromiso submaxilar en 58,3 % y de parótida en 41,7 %. Respecto a la intervención, al 29,2 % de los sujetos se le realizó extracción de cálculos, al 29,2 % sialoplastia, al 25 % dilatación de conductos y al 37,5 % lavado de conductos en el mismo momento quirúrgico. Conclusión. La sialoendoscopia y el abordaje mixto es un procedimiento que puede garantizar el manejo de patologías obstructivas y estenosis de los conductos salivales, con buen pronóstico y resultados, preservando la glándula y evitando las complicaciones de la cirugía.


Introduction. Sialoendoscopy is a procedure which purpose is to visualise the salivary ducts. It is used as a diagnostic and therapeutic method for inflammatory and obstructive processes and duct stenosis. Methods. To describe the procedures performed for the management of patients with inflammatory and obstructive pathology of the salivary glands, only with sialoendoscopy or with mixed approaches. Results. A total of 24 patients were included in the study, with mean age of 42 years, mostly female, and 58.3% submaxillary involvement 41.7% parotid involvement. Regarding the intervention, 29.2% of the subjects underwent stone extraction, 29.2%, sialoplasty, 25% duct dilatation, and 37.5% duct lavage at the same surgical time. Conclusions. Sialoendoscopy and the mixed approach is a procedure that can guarantee the management of obstructive pathologies and stenosis of the salivary ducts with good prognosis and results, preserving the gland and avoiding the complications of surgery.


Subject(s)
Humans , Salivary Gland Diseases , Salivary Glands , Minimally Invasive Surgical Procedures , Sialadenitis , Salivary Ducts , Endoscopy
SELECTION OF CITATIONS
SEARCH DETAIL