Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 1.908
J. Health NPEPS ; 7(1): 1-18, Jan-Jun, 2022.
Article in English | LILACS, BDENF, ColecionaSUS | ID: biblio-1396893


Objective:to present a spatial analysis of hospitalizations for schistosomiasis in Minas Gerais (2007-2017). Method:ecological study, with spatio-temporal distribution. Data collection was carried out in 2019, at DataSUS, for the period between 01/01/2007 and 12/31/2017. The average rates, Moran Local Bivariate rates and thematic maps were performed using the QGis program. Results:higher hospitalization rates were observed in the North, East and Northeast parts of the state. Lower rates were observed in the Southeastern portion. The variables MHDI and percentage of households without garbage collection had higher values of Local Moran Index. Municipalities in the eastern and southeastern portions of the state were classified under the "high-high" stratum. Conclusion:hospitalizations were associated with lack of basic sanitation, conditions of poverty and inequality and strong presence of water collections. There are still regions where schistosomiasis remains endemic, having a focused character.

Objetivo: presentar un análisis espacial de las hospitalizaciones por esquistosomiasis en Minas Gerais (2007-2017). Método: estudio ecológico, con distribución espacio-temporal. La recolección de datos se realizó en 2019, en DataSUS, para el período comprendido entre el 01/01/2007 y el 31/12/2017. Las tasas promedio, las tasas Bivariadas Locales de Moran y los mapas temáticos se realizaron mediante el programa QGis. Resultados: se observaron mayores tasas de hospitalización en las zonas Norte, Este y Noreste del Estado. Se observaron tasas más bajas en la parte Sureste. Las variables IDHM y porcentaje de viviendas sin recolección de basura presentaron valores más altos de Índice Moran Local. Los municipios de las partes este y sureste del estado se clasificaron en el estrato "alto-alto". Conclusión: las hospitalizaciones se asociaron a la falta de saneamiento básico, condiciones de pobreza y desigualdad y fuerte presencia de captaciones de agua. Todavía hay regiones donde la esquistosomiasis sigue siendo endémica, teniendo un carácter focalizado.

Objetivo:apresentar análise espacial das internações por esquistossomose em Minas Gerais (2007-2017). Método:estudo ecológico, com distribuição espaço-temporal. A coleta de dados foi realizada em 2019, no DataSUS, referente ao período entre 01/01/2007 e 31/12/2017. As taxas médias, as taxas de Moran Local Bivariado e os mapas temáticos foram realizados com uso do programa QGis. Resultados:foram observadas maiores taxas deinternação nas partes Norte, Leste e Nordeste do Estado. Menores taxas foram observadas na porção Sudeste. As variáveis IDHM e porcentagem de residências sem coleta de lixo tiveram maiores valores de índice de Moran Local. Municípios das porções Leste e Sudeste do Estado foram classificados sob estrato "alto-alto". Conclusão:as internações estiveram associadas à falta de saneamento básico, condições de pobreza e desigualdade,e forte presença de coletas de água. Ainda há regiões onde a esquistossomose permanece endêmica, tendo caráter focalizado.

Schistosomiasis , Brazil , Basic Sanitation
J. venom. anim. toxins incl. trop. dis ; 28: e20210108, 2022. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1386131


Background Eugenol shows both antibacterial and antiparasitic activities, suggesting that it might be evaluated as an option for the treatment of praziquantel-resistant schistosome. Methods The in vitro activities of three eugenol derivatives (FB1, FB4 and FB9) on adult worms from Schistosoma mansoni were examined by fluorescence and scanning electron microscopy to analyze effects on the excretory system and integument damage, respectively. Biochemical tests with verapamil (a calcium channel antagonist) and ouabain (a Na+/K+-ATPase pump inhibitor) were used to characterize eugenol derivative interactions with calcium channels and the Na+/K+-ATPase, while in silico analysis identified potential Na+/K+-ATPase binding sites. Results The compounds showed effective doses (ED50) of 0.324 mM (FB1), 0.167 mM (FB4), and 0.340 mM (FB9). In addition, FB4 (0.322 mM), which showed the lowest ED50, ED90 and ED100 (p < 0.05), caused the most damage to the excretory system and integument, according to both fluorescence and scanning electron microscopy analysis. The death of adult worms was delayed by ouabain treatment plus FB1 (192 versus 72 hours) and FB9 (192 versus 168 hours), but the response to FB4 was the same in the presence or absence of ouabain. Besides, no changes were noted when all of the eugenol derivatives were combined with verapamil. Moreover, FB1 and FB9 inhibited Na+/K+-ATPase activity according to in silico analysis but FB4 did not show a time-dependent relationship and may act on targets other than the parasite Na+/K+-ATPase. Conclusion Eugenol derivatives, mainly FB4 when compared to FB1 and FB9, seem to act more effectively on the integument of adult S. mansoni worms.(AU)

Schistosoma/drug effects , Schistosomiasis/drug therapy , Schistosomicides/analysis , In Vitro Techniques , Computer Simulation , Eugenol/analogs & derivatives , Neglected Diseases/drug therapy
Article in Chinese | WPRIM | ID: wpr-940951


OBJECTIVE@#To evaluate the diagnostic efficacy of indirect haemagglutination assay (IHA) for detection of Schistosoma japonicum infections among boatmen and fishermen in Dongting Lake region, so as to provide insights into improving the schistosomiasis surveillance program among boatmen and fishermen.@*METHODS@#The boatmen and fishermen were detected for S. japonicum infections using IHA and Kato-Katz technique or miracidium hatching test nylon gauze simultaneously at schistosomiasis testing sites in the anchor sites for boatmen and fishermen in the Dongting Lake region during the period from 2014 to 2016, and using IHA for serological screening followed by parasitological testing of seropositives during the period from 2017 to 2019. The sensitivity and specificity of IHA were evaluated for detection of S. japonicum infections among boatmen and fishermen, with the 2014-2016 parasitological testing results as a gold standard. In addition, the seroprevalence of S. japonicum infections was compared among boatmen and fishermen with different characteristics and among years.@*RESULTS@#A total of 306 schistosomiasis testing sites were assigned for boatmen and fishermen, and a total of 143 360 person-time boatmen and fishermen were tested for S. japonicum infections in the Dongting Lake region from 2014 to 2019. The sensitivity and specificity of IHA were 69.9%, 97.3% and 96.1% (χ2 = 74.6, P < 0.05), and 70.9%, 74.5% and 71.9% for detection of S. japonicum infections from 2014 to 2016 (χ2 = 29.4, P < 0.05), respectively. The seroprevalence of S. japonicum infections reduced from 30.3% in 2014 to 1.8% in 2019 among boatmen and fishermen, appearing an overall tendency towards a decline (Z = 1 552.4, P < 0.05). In addition, male, individuals at ages of 45 to 60 years, full-time boatmen and fishermen were more likely to be seropositive for S. japonicum infections (all P values < 0.05).@*CONCLUSIONS@#The seroprevalence of S. japonicum infections appeared a tendency towards a decline among boatmen and fishermen in the Dongting Lake region year by year from 2014 to 2019. IHA presented a high efficacy for screening of S. japonicum infections among boatmen and fishermen in the Dongting Lake region.

Animals , China/epidemiology , Hemagglutination , Humans , Lakes , Male , Middle Aged , Prevalence , Schistosoma japonicum , Schistosomiasis/epidemiology , Schistosomiasis japonica/prevention & control , Seroepidemiologic Studies
Article in Chinese | WPRIM | ID: wpr-940943


Currently, the national schistosomiasis control program of China is moving from transmission interruption to elimination, and there are multiple challenges during the stage moving towards the progression of schistosomiasis elimination, including a high difficulty in shrinking snail-infested areas, unstable achievements for infectious source control, imperfect surveillance system and a reduction in schistosomiasis control and administration. Based on the core suggestions proposed in the 2022 WHO guideline on control and elimination of human schistosomiasis, recommendations on schistosomiasis surveillance system building, development of novel diagnostics, adjustment of the schistosomiasis control strategy and maintaining and improvements of the schistosomiasis control capability are proposed for the national schistosomiasis control program of China in the new era according to the actual status of schistosomiasis control in China. Formulation of the national schistosomiasis control strategy and goal from One Health perspective, verification of transmission interruption and elimination of schistosomiasis, precision implementation of schistosomiasis control interventions with adaptations to local circumstances, development and application of highly sensitive and specific diagnostics are recommended for elimination of schistosomiasis in China. In addition, the implementation of the 2022 WHO guideline on control and elimination of human schistosomiasis may guide the elimination of schistosomiasis in China.

Animals , China/epidemiology , Goals , Humans , Schistosomiasis/prevention & control , Snails , World Health Organization
Article in Chinese | WPRIM | ID: wpr-940942


Schistosomiasis is a parasitic disease that seriously hinders socioeconomic developments and threatens public health security. To achieve the global elimination of schistosomiasis as a public health problem by 2030, WHO released the guideline on control and elimination of human schistosomiasis on February, 2022, with aims to provide evidence-based recommendations for schistosomiasis morbidity control, elimination of schistosomiasis as a public health problem, and ultimate interruption of schistosomiasis transmission in disease-endemic countries. Following concerted efforts for decades, great achievements have been obtained for schistosomiasis control in China where the disease was historically highly prevalent, and the country is moving towards schistosomiasis elimination. This article reviews the successful experiences from the national schistosmiasis control program in China, and summarizes their contributions to the formulation and implementation of the WHO guideline on control and elimination of human schistosomiasis. With the progress of the "Belt and Road" initiative, the world is looking forward to more China's solutions on schistosomiasis control.

China/epidemiology , Disease Eradication , Humans , Public Health , Schistosomiasis/prevention & control , World Health Organization
Article in Chinese | WPRIM | ID: wpr-940941


Preventive chemotherapy is one of the pivotal interventions for the control and elimination of schistosomiasis, which is effective to reduce the morbidity and prevalence of schistosomiasis. In order to promote the United Nations' sustainable development goals and the targets set for schistosomiasis control in the Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021-2030, WHO released the guideline on control and elimination of human schistosomiasis in 2022, with major evidence-based updates of the current preventive chemotherapy strategy for schistosomiasis. In China where great success has been achieved in schistosomiasis control, the preventive chemotherapy strategy for schistosomiasis has been updated several times during the past seven decades. This article reviews the evolution of the WHO guidelines on preventive chemotherapy and Chinese national preventive chemotherapy schemes, compares the current Chinese national preventive chemotherapy scheme and the recommendations for preventive chemotherapy proposed in the 2022 WHO guideline on control and elimination of human schistosomiasis, and proposes recommendations for preventive chemotherapy during the future implementation of the 2022 WHO guideline, so as to provide insights into schistosomiasis control among public health professionals engaging in healthcare foreign aid.

China/epidemiology , Humans , Prevalence , Public Health , Schistosomiasis/prevention & control , World Health Organization
Article in Chinese | WPRIM | ID: wpr-940940


On February 2022, WHO released the evidence-based guideline on control and elimination of human schistosomiasis, with aims to guide the elimination of schistosomiasis as a public health problem in disease-endemic countries by 2030 and promote the interruption of schistosomiasis transmission across the world. Based on the One Health concept, six evidence-based recommendations were proposed in this guideline. This article aims to analyze the feasibility of key aspects of this guideline in Chinese national schistosomiasis control program and illustrate the significance to guide the future actions for Chinese national schistosomiasis control program. Currently, the One Health concept has been embodied in the Chinese national schistosomiasis control program. Based on this new WHO guideline, the following recommendations are proposed for the national schistosomiasis control program of China: (1) improving the systematic framework building, facilitating the agreement of the cross-sectoral consensus, and building a high-level leadership group; (2) optimizing the current human and livestock treatments in the national schistosomiasis control program of China; (3) developing highly sensitive and specific diagnostics and the framework for verifying elimination of schistosomiasis; (4) accelerating the progress towards elimination of schistosomiasis and other parasitic diseases through integrating the national control programs for other parasitic diseases.

China/epidemiology , Disease Eradication , Humans , Public Health , Schistosomiasis/prevention & control , World Health Organization
Chinese Journal of Hepatology ; (12): 45-51, 2022.
Article in Chinese | WPRIM | ID: wpr-935901


Objective: To compare the effects of artesunate (Art) and fuzheng huayu decoction on mitochondrial autophagy in the treatment of schistosomiasis liver fibrosis. Methods: Eighty C57BL/6 female mice were randomly divided into healthy control group, infection group, Art treatment group and Fuzheng Huayu Decoction treatment group, with 20 mice in each group. Mice in the infection group and treatment group were infected with 16 Schistosoma japonicum cercariae. After 6 weeks, praziquantel (300 mg/kg) was used for 2 days to kill the worms. The Art treatment group was treated with intraperitoneal injection of 100 mg/kg/day, while the Fuzheng Huayu Decoction treatment group was fed 16g of fuzheng huayu decoction per 1kg per day. After 6 weeks, fresh liver tissues of the four groups were collected. Masson staining and Western blot were used to observe the succinate dehydrogenase subunit A (SDHA) and malate dehydrogenase (MDH2), citrate synthase (CS), ketoglutarate dehydrogenase (OGDH), and target of rapamycin 1 (mTORC1) pathway involved in mitochondrial tricarboxylic acid cycle in liver tissues. The relative expression levels of adenylate activated protein kinase (AMPK) and mitochondrial autophagy pathway kinase (PINK1) were detected. Liver tissue samples were extracted from each group to detect the mitochondrial oxygen consumption rate. Two-way ANOVA was used to compare the significance and difference between two sets of samples. Results: Masson staining showed that the infection group mice had significantly higher liver fibrosis area than the healthy control group, while the Art treatment group and Fuzheng Huayu Decoction treatment group mice had lower liver fibrosis area than the infection group. Western blot analysis showed that the infection group (0.82 ± 0.05) had significantly lower relative expression of SDHA protein than the healthy control group (1.00 ± 0.05) (t = 11.23, P = 0.0035), while the Art treatment group (0.73 ± 0.05) had significantly higher relative expression of SDHA protein than the infection group (t = 10.79, P = 0.0073). However, there was no significant change in Fuzheng Huayu Decoction treatment group (0.98±0.05) (t = 1.925, P = 0.1266). The relative expression of p-AMPK protein was significantly higher in the infection group (1.15 ±0.05) than in the healthy control group (0.98 ± 0.07, t = 12.18, P = 0.0029), and the expression of p-AMPK in the Art treatment group (0.50 ± 0.05) was significantly lower than the infection group (t = 11.78, P = 0.0032). The relative protein expression of AMPK was significantly lower in the infection group (0.80 ± 0.05) than in the healthy control group (1.00 ± 0.05, t = 10.53, P = 0.0046). The expression of AMPK was significantly lower in the Art treatment group (0.54 ± 0.05) than in the infection group (T = 13.98, P = 0.0036). The relative expression of p-mTORC1 protein (0.93 ± 0.08) was not significantly different in the infection group than in the healthy control group (t = 2.28, P = 0.065), while the Art treatment group (0.63 ± 0.05) had significantly lower relative expression of p-mTORC1 protein than the infection group (t = 10.58, P = 0.029). The expression of p-mTORC1/ m-TORC1 was not significantly different in the infection group (0.98 ± 0.03) than in the healthy control group (0.97 ± 0.03, t = 0.98, P = 0.085), while the Art treatment group (0.63 ± 0.05) had significantly lower relative expression of p-mTORC1/ m-TORC1 than the infection group (t = 14.58, P = 0. 009). The relative protein expression of PINK1 was significantly lower in the infection group (0.55 ± 0.05) than in the healthy control group (1.00 ± 0.03, t = 13.49, P = 0.0011), while the Art treatment group (1.21 ± 0.05, t = 9.98, P = 0.0046) and Fuzheng Huayu Decoction treatment group (1.31 ±0.35, t = 6.98, P = 0.027) had significantly higher relative protein expression of PINK1 than the infection group. Mitochondrial function tests showed that after adding substrate complex II, the oxygen consumption of the infection group was lower than the healthy control group, while the Art treatment group and the Fuzheng Huayu Decoction treatment group had higher oxygen consumption than the infection group. The oxygen consumption was significantly lower after adding the substrate complex III in the infection group than the healthy control group, while the Art treatment group and Fuzheng Huayu Decoction treatment group had higher oxygen consumption than the infection group. Conclusion: Art can alleviate schistosomiasis liver fibrosis by inhibiting AMPK/mTORC1 signaling pathway activity and enhancing mitochondrial oxygen consumption, autophagy and SDHA expression.

Animals , Artesunate , Drugs, Chinese Herbal/therapeutic use , Female , Liver Cirrhosis/drug therapy , Mice , Mice, Inbred C57BL , Mitochondria , Schistosomiasis
RECIIS (Online) ; 15(1): 201-210, jan.-mar. 2021. ilus
Article in Portuguese | LILACS | ID: biblio-1177407


O trabalho dos educadores pode ser enriquecido com o uso de recursos pedagógicos importantes no processo de ensino e aprendizagem. Considerando este aspecto, uma animação baseada no livro O feitiço da lagoa, de Virginia Schall, que trata do tema esquistossomose foi construída para estimular o conhecimento sobre a doença entre escolares e exibida para alunos do ensino básico em quatro municípios endêmicos: Jaboticatubas, Malacacheta e Santa Luzia, em Minas Gerais; e João Pessoa, na Paraíba. Após sua exibição, um questionário foi aplicado com a finalidade de verificar a aceitação e o entendimento do material. De acordo com as respostas, o desenho animado apresentou boa aceitação. Todos identificaram a esquistossomose como a doença retratada e o caramujo como o transmissor do esquistossomo. Os resultados apontaram que o desenho pode ser um importante recurso pedagógico no processo educativo, auxiliando os programas de controle da endemia, especialmente quando desenvolvidos no espaço escolar.

The educators' work can be enriched with the use of pedagogical resources which are important in the teaching and learning process. With this aspect in mind, a cartoon with the theme schistosomiasis was created, so as to promote knowledge about the disease among middle school students, and exhibited in four endemic municipalities - Jaboticatubas, Malacacheta and Santa Luzia in the state of Minas Gerais; and João Pessoa in the state of Paraíba. The animation was based on the book O feitiço da lagoa by Virginia Schall and it was shown to students in those four towns. A questionnaire was answered by them after the respective exhibitions in order to verify the acceptance and understanding of the material that was shown. According to the responses, the cartoon presented good acceptance. Everyone identified schistosomiasis as the disease displayed, and the snail that transmits the schistosome. The results showed that the cartoon can be an important pedagogical resource in the educational process, helping endemic control programs, especially when these programs are developed in the school environment.

El trabajo de los educadores puede ser enriquecido con el uso de recursos pedagógicos importantes en el proceso de enseñanza y aprendizaje. Considerando este aspecto, un dibujo animado sobre el tema esquistosomiasis fue realizado para estimular el conocimiento, entre estudiantes del ciclo básico, acerca de la enfermedad y exhibido en cuatro municipios endémicos: Jaboticatubas, Malacacheta y Santa Luzia en Minas Gerais; y João Pessoa en Paraíba. La animación fue basada en el libro O feitiço da lagoa de Virginia Schall y fue mostrada a alumnos en las cuatro localidades. Un cuestionario fue aplicado, después de cada proyección, con la finalidad de verificar la aceptación y el entendimiento del material exhibido. De acuerdo con las respuestas, el dibujo tuvo buena aceptación. Todos identificaron la esquistosomiasis como la enfermedad retratada y el caracol como el transmisor del esquistosoma. Los resultados indicaran que el dibujo animado puede ser un importante recurso pedagógico en el proceso educativo, auxiliando a los programas de control de la endemia, especialmente cuando desarrollados en el espacio escolar.

Humans , Schistosomiasis , Health Education , Education, Primary and Secondary , Educational and Promotional Materials , Health Communication , Brazil , Surveys and Questionnaires , Drawing
ABCD arq. bras. cir. dig ; 34(4): e1638, 2021. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1360019


RESUMO - RACIONAL: O tratamento endoscópico das varizes esofágicas tem sido utilizado como principal intervenção em pacientes com hipertensão portal secundária à esquistossomose, mas com taxas significativas de recorrência de varizes esofágicas e ressangramento. Os resultados em longo prazo do tratamento endoscópico exclusivo são pouco estudados quanto à relação das dimensões esplênicas neste contexto. OBJETIVO: Avaliar, por meio da ultrassonografia, o índice esplênico e a dimensão longitudinal (craniocaudal) do baço como preditores de ressangramento e recorrência de varizes no seguimento tardio de pacientes esquistossomóticos não operados, após erradicação endoscópica das varizes esofágicas. MÉTODOS: Estudo observacional retrospectivo por meio da análise de prontuários de pacientes com diagnóstico de esquistossomose hepatoesplênica. A curva ROC foi usada para determinar o melhor ponto de corte para o índice esplênico médio como preditor de recorrência e sangramento. RESULTADOS: Foram analisados 54 pacientes, durante o período de 2002 a 2018. O tempo médio de seguimento foi de 8 anos. O índice esplênico provou ser um teste sensível em valores acima de 144 como preditor de ressangramento. Na análise da dimensão longitudinal, o valor acima de 20 cm apresentou teste estatisticamente significativo para recorrência de varizes e valor acima de 19 cm apresentou-se como teste muito sensível e estatisticamente significativo para ressangramento. CONCLUSÃO: A análise do índice esplênico e da dimensão craniocaudal, obtidos por ultrassonografia, podem predizer recorrência de varizes e ressangramento após erradicação endoscópica exclusiva.

ABSTRACT - BACKGROUND: Endoscopic treatment for esophageal variceal has been used as the main intervention in patients with portal hypertension secondary to schistosomiasis, but with significant rates of recurrence of esophageal variceal and rebleeding. The long-term results of exclusive endoscopic treatment are poorly studied as the relationship of the splenic dimensions in this context. AIM: The aim of this study was to identify, through ultrasonography, whether the splenic index and the longitudinal (craniocaudal) dimension of the spleen are the predictors of rebleeding and variceal recurrence in late follow-up of patients with nonoperated schistosomiasis, after endoscopic eradication of esophageal variceal. METHODS: This is a retrospective and observational study analyzing the medical records of patients diagnosed with hepatosplenic schistosomiasis. The receiver operating characteristic curve was used to determine the best cutoff point for the mean splenic index as a predictor of recurrence and bleeding. Results: A follow-up of 54 patients were analyzed during the period from 2002 to 2018. The mean follow-up time was 8 years. The splenic index with value >144 was proved to be a sensitive test for rebleeding. In the analysis of the longitudinal dimension, the spleen length of >20 cm showed a statistically significant test for recurrence of variceal and a length >19 cm presented as a very sensitive and statistically significant test for rebleeding. CONCLUSION: Splenic index and craniocaudal dimension analysis, obtained by ultrasonography, can predict recurrence of varicose veins and rebleeding after exclusive endoscopic treatment.

Humans , Schistosomiasis , Esophageal and Gastric Varices/surgery , Esophageal and Gastric Varices/diagnostic imaging , Spleen/surgery , Spleen/diagnostic imaging , Retrospective Studies , Follow-Up Studies , Gastrointestinal Hemorrhage/surgery , Gastrointestinal Hemorrhage/etiology , Gastrointestinal Hemorrhage/diagnostic imaging , Neoplasm Recurrence, Local
ABCD arq. bras. cir. dig ; 34(2): e1581, 2021. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1345002


ABSTRACT Background: The treatment of choice for patients with schistosomiasis with previous episode of varices is bleeding esophagogastric devascularization and splenectomy (EGDS) in association with postoperative endoscopic therapy. However, studies have shown varices recurrence especially after long-term follow-up. Aim: To assess the impact on behavior of esophageal varices and bleeding recurrence after post-operative endoscopic treatment of patients submitted to EGDS. Methods: Thirty-six patients submitted to EGDS were followed for more than five years. They were divided into two groups, according to the portal pressure drop, more or less than 30%, and compared with the behavior of esophageal varices and the rate of bleeding recurrence. Results: A significant reduction on the early and late post-operative varices caliber when compared the pre-operative data was observed despite an increase in diameter during follow-up that was controlled by endoscopic therapy. Conclusion: The drop in portal pressure did not significantly influence the variation of variceal calibers when comparing pre-operative and early or late post-operative diameters. The comparison between the portal pressure drop and the rebleeding rates was also not significant.

RESUMO Racional: O tratamento de escolha para pacientes com hipertensão portal esquistossomótica com sangramento de varizes é a desconexão ázigo-portal mais esplenectomia (DAPE) associada à terapia endoscópica. Porém, estudos mostram aumento do calibre das varizes em alguns pacientes durante o seguimento em longo prazo. Objetivo: Avaliar o impacto da DAPE e tratamento endoscópico pós-operatório no comportamento das varizes esofágicas e recidiva hemorrágica, de pacientes esquistossomóticos. Métodos: Foram estudados 36 pacientes com seguimento superior a cinco anos, distribuídos em dois grupos: queda da pressão portal abaixo de 30% e acima de 30% comparados com o calibre das varizes esofágicas no pós-operatório precoce e tardio além do índice de recidiva hemorrágica. Resultados: Após a DAPE houve diminuição significativa no calibre das varizes esofágicas que, durante o seguimento aumentaram de calibre e foram controladas com tratamento endoscópico. A queda da pressão portal não influenciou significativamente o comportamento do calibre das varizes no pós-operatório precoce nem tardio nem os índices de recidiva hemorrágica. Conclusão: A queda na pressão portal não influenciou significativamente a variação dos calibres das varizes ao comparar os diâmetros pré e pós-operatórios precoces ou tardios. A comparação entre a queda de pressão do portal e as taxas de ressangramento também não foi significativa.

Humans , Schistosomiasis , Esophageal and Gastric Varices/surgery , Hypertension, Portal/surgery , Recurrence , Splenectomy , Follow-Up Studies , Portal Pressure , Gastrointestinal Hemorrhage/surgery , Gastrointestinal Hemorrhage/etiology
Rev. patol. trop ; 50(4)2021. ilus, tab
Article in English | LILACS | ID: biblio-1353272


Schistosomiasis is still a serious public health concern in Brazil and Sergipe State presents the highest prevalence rate of the disease. Brazil implemented the Schistosomiasis Control Program (PCE) with several strategies to control the disease, including health education actions in endemic areas. Herein, we assessed the impact of an educational intervention on knowledge concerning schistosomiasis in students from a riverside village of Sergipe, Northeastern Brazil. The study was carried out in 3 phases. 1) A questionnaire was applied to assess the students' knowledge about the biological, clinical, and epidemiological aspects of schistosomiasis mansoni (pre-test). 2) Next, an educational intervention was conducted. Pamphlets about schistosomiasis were distributed to the entire school community, who were then invited to a lecture. 3) A post-test was performed using the questionnaire to assess acquired knowledge. 151 elementary school students were interviewed. 2.6% of the pre-test students and 4.3% of the post-test group had already been diagnosed with schistosomiasis. In the pre-test, only 24.5% knew the cause of the disease and 48.3% the transmission sites. In the post-test, 74.3% (OR= 8.9; p-value<0.0001) knew the etiology and 77.1% the possible transmission sites (OR= 3.6; p-value<0.0001). There was also significant improvement in knowledge regarding signs, symptoms and prophylactic measures. Most students were unaware of the risk of reinfection by Schistosoma mansoni after treatment. The educational intervention proved quite effective in increasing information on schistosomiasis. These results reinforce the importance of health education as an auxiliary tool in the control of schistosomiasis.

Schistosoma mansoni , Schistosomiasis , Public Health , Health Education
Article in English | WPRIM | ID: wpr-922256


To investigate the relationship between salt-inducible kinase 2 (SIK2) and lymph node metastasis in colorectal cancer patients complicated with chronic schistosomiasis. Tissue specimens were collected from 363 patients who were diagnosed as colorectal cancer by clinical and pathological examination in Wuhu Second People's Hospital from June 2015 to June 2020. Fifty-six patients were colorectal cancer complicated with schistosomiasis (CRC-S) and 307 patients were colorectal cancer not complicated with schistosomiasis (CRC-NS). The clinical and pathological data of the patients were analyzed to explore the relationship between chronic schistosomiasis and colorectal cancer. Immunohistochemistry and Western blotting were used to detect the distribution and expression of SIK2 in colorectal cancer specimens. The relationship between SIK2 and lymph node metastasis of CRC-S was analyzed. The rate of lymph node metastasis in CRC-S group was significantly higher than that in CRC-NS group (62.5% vs. 47.2%, <0.05). In CRC-S patients with lymph node metastasis, schistosome eggs were distributed mainly in tumor tissues (25/35, 71.4%), while in patients with CRC-S without lymph node metastasis, schistosome eggs were distributed mainly in paracancerous tissues (17/21, 81.0%) (14.243, <0.01). The SIK2 was mainly located in cytosol, and its expression in tumor tissues was higher than that in paracancerous tissues. Compared with CRC-NS patients, the expression of SIK2 in CRC-S patients was significantly increased; the expression of SIK2 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis; and the expression of SIK2 in patients with schistosome eggs in cancer tissues was higher than that in patients with schistosome eggs in paracancerous tissues (all <0.01). Lymph node metastasis is more likely to be occurred in colorectal cancer patients with schistosomiasis, especially in those with schistosome eggs in tumor tissues. The expression of SIK2 may be correlated with chronic schistosomiasis, egg distribution and lymphatic metastasis.

Biomarkers, Tumor , Colorectal Neoplasms/complications , Humans , Immunohistochemistry , Lymphatic Metastasis , Neoplasm Staging , Prognosis , Schistosomiasis/complications
Rev. Soc. Bras. Med. Trop ; 54: e01452020, 2021. tab, graf
Article in English | LILACS, ColecionaSUS, SES-SP | ID: biblio-1143891


Abstract INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.

Humans , Animals , Schistosomiasis/genetics , Mannose-Binding Lectin/genetics , Polymorphism, Genetic , Brazil , Exons/genetics , Retrospective Studies , Genetic Predisposition to Disease , Polymorphism, Single Nucleotide , Genotype , Liver Cirrhosis/genetics
Rev. Soc. Bras. Med. Trop ; 54: e08512020, 2021. tab, graf
Article in English | LILACS | ID: biblio-1288085


Abstract INTRODUCTION: Ourinhos is a municipality located between the Pardo and Paranapanema rivers, and it has been characterized by the endemic transmission of schistosomiasis since 1952. We used geospatial analysis to identify areas prone to human schistosomiasis infections in Ourinhos. We studied the association between the sewage network, co-occurrence of Biomphalaria snails (identified as intermediate hosts [IHs] of Schistosoma mansoni), and autochthonous cases. METHODS: Gi spatial statistics, Ripley's K12-function, and kernel density estimation were used to evaluate the association between schistosomiasis data reported during 2007-2016 and the occurrence of IHs during 2015-2017. These data were superimposed on the municipality sewage network data. RESULTS: We used 20 points with reported IH; they were colonized predominantly by Biomphalaria glabrata, followed by B. tenagophila and B. straminea. Based on Gi statistics, a significant cluster of autochthonous cases was superimposed on the Christoni and Água da Veada water bodies, with distances of approximately 300 m and 2200 m from the points where B. glabrata and B. straminea were present, respectively. CONCLUSIONS: The residence geographical location of autochthonous cases allied with the spatial analysis of IHs and the coverage of the sewage network provide important information for the detection of human-infection areas. Our results demonstrated that the tools used for direct surveillance, control, and elimination of schistosomiasis are appropriate.

Humans , Animals , Schistosomiasis/epidemiology , Biomphalaria , Schistosomiasis mansoni/epidemiology , Schistosoma mansoni , Sewage , Brazil/epidemiology , Geographic Information Systems , Disease Vectors
Rev. bras. anal. clin ; 52(3): 224-227, 20200930.
Article in Portuguese | LILACS | ID: biblio-1255086


A esquistossomose mansônica é uma enfermidade parasitária causada por um trematódeo digenético da família Schistosomatidae, gênero Schistosoma, que vive na corrente sanguínea do hospedeiro definitivo, o homem. As suas formas variam quanto à evolução clínica de maneira assintomática até agudamente grave, podendo levar ao óbito. É um parasita que tem afinidade por regiões tropicais, como o Brasil, onde a temperatura é elevada, principalmente no Norte e Nordeste do país. Junto com a clínica do paciente e exames laboratoriais é possível ter-se um diagnóstico fidedigno dessa enfermidade. As formas de tratamento para essa patologia segue o farmacológico e depende da fase em que se encontra a infecção, havendo necessidade de implantação de medidas preventivas para o controle dessa doença. Com base no exposto, este estudo, por meio da revisão de literatura, tem como objetivo explorar os aspectos clínicos e laboratoriais da esquistossomose mansônica, agente etiológico, tratamento e medida de profilaxia e controle. Portanto, a revisão literária foi feito a partir das bases de dados Scielo, Pubmed assim como livros, guias, textos sobre o assunto, visando conceber um apurado de publicações no sentido de sintetizar um objeto de consulta para uma melhor conscientização da comunidade médico-científica.

Schistosomiasis mansoni is a parasitic disease caused by a digenético trematódeo of the family Schistosomatidae, genus Schistosoma that lives in the sanguineous blood of the definitive host, the man. Its forms vary in clinical evolution from asymptomatic to acutely severe, leading to death. It is a parasite that has affinity for tropical regions, such as Brazil, where the temperature is high, mainly in the North and Northeas of the country. Together with the patient's clinic and laboratory tests, it is possible to have a reliable diagnosis of this disease. The forms of treatment for this pathology follow the pharmacological and depends on the stage of the infection and there is a need to implement preventive measures for the control of this disease. Based on the foregoing, this study, through the literature review, aims to explore the clinical and laboratory aspects of schistosomiasis mansoni, etiologic agent, treatment and measurement of prophylaxis and control. Therefore, the literary review was done from the Scielo, Pubmed databases as well as books, guides, texts on the subject, aiming at conceiving a publication search to synthesize an object of consultation for a better awareness of the scientific medical community.

Humans , Schistosomiasis/diagnosis , Schistosomiasis/drug therapy , Endemic Diseases
Rev. baiana saúde pública ; 44(3): 143-159, 20200813.
Article in Portuguese | LILACS | ID: biblio-1371025


As doenças tropicais negligenciadas são associadas às populações desfavorecidas socioeconomicamente e muitas delas apresentam alta prevalência no Nordeste brasileiro. Diante disso, o objetivo desta revisão de literatura foi descrever o perfil epidemiológico da leishmaniose, da esquistossomose e da doença de Chagas nessa região, bem como os determinantes sociais envolvidos na manutenção dessas doenças. Trata-se de uma revisão narrativa da literatura do tipo descritiva. Foram detectados cem artigos publicados entre 2012 e 2017 nas bases bibliográficas. Desses, 72 foram selecionados para leitura completa. Após leitura integral e aplicação dos critérios de seleção, restaram 39 artigos. Os resultados convergentes para as três doenças estudadas relacionaram-se às condições inadequadas de vida em sociedade, à baixa escolaridade e à organização falha da estrutura habitacional. A partir da descrição do perfil epidemiológico dessas enfermidades, foi possível ratificar que as variáveis sociais são determinantes para a manutenção dessas condições de saúde. Por fim, os fatores identificados neste estudo foram válidos visando a construção do mapeamento de áreas de risco, além de serem importantes para estudantes da área da saúde, uma vez que compõem o acervo de estudos disponíveis e necessários na capacitação de futuros profissionais no enfrentamento de tais problemas sociais.

Neglected Tropical Diseases are associated with socioeconomically disadvantaged populations, and many of them show high prevalence in Northeast Brazil. Hence, this descriptive narrative literature review describes the epidemiological profile of Leishmaniasis, Schistosomiasis and Chagas disease in the region, as well as the social determinants involved in their proliferation. The database search returned 100 articles published between 2012 and 2017, of which 72 were selected for full reading. After applying the selection criteria, 39 articles remained. The converging results for the three studied diseases were related to inadequate living conditions, low schooling levels, and poor housing infrastructure. From this epidemiological profile, the study confirmed that social variables are determinants for the proliferation of these diseases. Finally, the factors identified here were valid and useful for mapping risk areas, and proved important for healthcare students, since they make up the set of studies available for future professionals and necessary for addressing such social issues.

Las enfermedades tropicales desatendidas están asociadas a las poblaciones desfavorecidas socioeconómicamente y presentan, en la mayoría de los casos, alta prevalencia en el Nordeste brasileño. Con ello, el objetivo de esta revisión de literatura fue describir el perfil epidemiológico de la leishmaniasis, esquistosomiasis y enfermedad de Chagas en esa región, así como los determinantes sociales involucrados en su mantenimiento. Esta es una revisión narrativa de la literatura, de carácter descriptivo. En las bases bibliográficas se detectaron cien artículos publicados entre 2012 y 2017. De estos, setenta y dos fueron seleccionados para una lectura completa. Tras la lectura completa y aplicación de los criterios de selección, quedaron 39 artículos. Los resultados convergentes para las tres enfermedades estudiadas se relacionaron con las condiciones inadecuadas de vida en sociedad, a la baja escolaridad y a una inadecuada organización de la estructura habitacional. A partir de la descripción del perfil epidemiológico de esas enfermedades, fue posible ratificar que las variables sociales son determinantes para el mantenimiento de estas condiciones de salud. Los factores identificados en este estudio fueron válidos para elaborar un mapeo de áreas de riesgo, pero también son importantes para los estudiantes del área de la salud debido a que esta cuestión compone la temática disponible y necesaria a la formación de los futuros profesionales para enfrentar este tipo de problema social.

Humans , Schistosomiasis , Health Profile , Leishmaniasis , Chagas Disease , Delivery of Health Care , Neglected Diseases
Semina cienc. biol. saude ; 41(2): 191-202, jun./dez. 2020. Ilus
Article in Portuguese | LILACS | ID: biblio-1224294


A esquistossomose é uma doença parasitária endêmica em áreas tropicais, apresentando grande importância para a saúde pública no Brasil. Minas Gerais é um dos estados brasileiros que apresenta maior prevalência da doença. Objetivamos descrever os casos de esquistossomose nos municípios de Juatuba e Florestal, Região Metropolitana de Belo Horizonte, Minas Gerais, e identificar o perfil dos infectados. Realizamos consulta às informações contidas nas fichas de notificação da doença, referentes ao período de 2009-2012, fornecidas pelo Setor de Epidemiologia dos dois municípios. Constatamos que no ano de 2011 houve um pico de casos da doença em Juatuba. Observamos um maior número de casos da esquistossomose em indivíduos do sexo masculino e na faixa etária de 15- 49 anos, em ambos os municípios. No município de Juatuba, os casos de esquistossomose notificados foram, em sua maioria, de moradores residentes em área urbana. Finalmente, constatamos que os cursos hídricos, prováveis focos de esquistossomose, encontram-se em pontos periféricos e distintos, em ambos os municípios. Para o sucesso no controle da doença nos municípios, e em extensão para outros municípios brasileiros, sugerimos a implantação de medidas e ações de prevenção e controle ambiental e educação em saúde para a população.(AU)

Schistosomiasis is an endemic parasitic disease in tropical areas, of great importance for public health in Brazil. Minas Gerais is one of the Brazilian states with the highest prevalence of the disease. We objectived to describe the cases of schistosomiasis in the municipalities of Juatuba and Florestal, metropolitan region of Belo Horizonte, Minas Gerais, and to identify the profile of those infected. For this, we consulted the information contained in the disease notification forms provided by the epidemiology sector of the two municipalities between 2009-2012. We found that in 2011 the disease peaked in Juatuba. We observed a higher number of cases of schistosomiasis in males aged 15-49 years in both municipalities. In the municipality of Juatuba, most cases of schistosomiasis were reported to be residents of urban areas. Finally, we found that the water courses, probable foci of schistosomiasis, are in peripheral and distinct points in both municipalities. For the successful control of the disease in the municipalities, and in extension to other Brazilian municipalities, we suggest the implementation of measures and actions for prevention and environmental control and health education for the population.(AU)

Humans , Schistosomiasis , Public Health , Epidemiology , Parasitic Diseases , Disease , Disease Notification
Article in English | AIM | ID: biblio-1257711


Background: Schistosomiasis is associated with agriculture and water development schemes, and farmworkers are particularly vulnerable to this disease because of their regular contact with water. Aim: To determine the level of knowledge, attitude and practices (KAP) of farmworkers regarding schistosomiasis. Setting: This study was conducted in Vuvha, a rural community under Makhado municipality, Vhembe district, Limpopo Province, South Africa. Methods: A quantitative, cross-sectional design was used. A self-administered questionnaire was used for data collection, and data were analysed using descriptive and inferential statistical techniques. Results: The majority were knowledgeable about the cause of schistosomiasis (84.3%), knew the mode of transmission of the disease (90.2%). However, about half of the participants knew the symptoms of schistosomiasis. Sixty-eight (33.4%) believed that schistosomiasis was not a problem in their community. The majority (77.9%) agreed that it was abnormal to pass blood in urine, while 85.8% agreed that medical consultation was the right thing to do when symptoms are observed. Fifty-five participants (27.0%) reported ever passing bloody urine. Among those who passed bloody urine, 43 (78.2%) consulted a doctor. Fifty-two (26.0%) participants reported ever being treated for schistosomiasis. Conclusion: The level of knowledge about the cause of schistosomiasis is high among the participants; similarly, there are positive attitudes and good practices shown in this study, but there are some gaps that need to be addressed. Efforts should be made to continue to educate farmworkers because they are at an increased risk for contracting schistosomiasis

Farmers , Health Knowledge, Attitudes, Practice , Schistosomiasis , Schistosomiasis/statistics & numerical data , South Africa
Epidemiol. serv. saúde ; 29(2): e2019252, 2020. tab, graf
Article in Portuguese | LILACS | ID: biblio-1101128


Resumo Objetivo: descrever as ações de controle e a situação epidemiológica da esquistossomose, em Pernambuco, Brasil, 2010-2016. Métodos: estudo descritivo, com dados do Sistema de Informação do Programa de Vigilância e Controle da Esquistossomose em 116 municípios, incluindo indicadores relacionados às ações de controle (população trabalhada, exames realizados, cobertura de tratamento) e epidemiológicas (positividade, carga parasitária, outras helmintoses). Resultados: as II, III, IV, V e XII regiões de saúde do estado, tradicionalmente endêmicas, registraram maiores percentuais médios para ações de controle (população trabalhada [6,5%, 6,0%, 2,0%, 12,0% e 13,0%], exames realizados [75,0%, 75,5%, 74,0%, 74,0% e 68,5%] e cobertura de tratamento [71,0%, 82,5%, 82,0%, 91,0% e 73,0%], respectivamente), e maiores percentuais médios para variáveis epidemiológicas (positividade [3,5%, 8,0%, 1,0%, 2,0% e 6,5%], alta carga parasitária [0,1%, 0,7%, 0,02%, 0,03% e 0,5%] e outras helmintoses [4,0%, 11,0%, 4,0%, 6,0% e 8,0%], respectivamente). Conclusão: deve-se ampliar as ações de controle nas regiões tradicionalmente endêmicas.

Resumen Objetivo: describir las acciones de control y la situación epidemiológica de la esquistosomiasis, Pernambuco, Brasil, 2010-2016. Métodos: estudio descriptivo utilizando datos del Sistema de Información del Programa de Vigilancia y Control de Esquistosomiasis en 116 municipios, incluyendo indicadores relacionados con acciones de control (población trabajada, pruebas realizadas, cobertura del tratamiento) y epidemiológicas (positividad, carga parasitaria, otros helmintos). Resultados: las regiones de salud II, III, IV, V y XII del estado, tradicionalmente endémicas, registraron porcentajes promedios más altos para las acciones de control (población trabajada [6,5%, 6,0%, 2,0%, 12,0% y 13,0%], exámenes [75,0%, 75,5%, 74,0%, 74,0% y 68,5%] y tratamiento [71,0%, 82,5%, 82,0%, 91,0% y 73,0%], respectivamente), y porcentajes promedios más altos para variables epidemiológicas (positividad [3,5%, 8,0%, 1,0%, 2,0% y 6,5%], alta carga parasitaria [0,1%, 0,7%, 0,02%, 0,03% y 0,5%] y otros helmintos [4,0%, 11,0%, 4,0%, 6,0% y 8,0%], respectivamente). Conclusión: ampliar las acciones de control en regiones tradicionalmente endémicas.

Abstract Objective: to describe schistosomiasis control actions and its epidemiological situation in Pernambuco, Brazil, 2010-2016. Methods: this was a descriptive study using data from the Schistosomiasis Surveillance and Control Program Information System for 116 municipalities, including indicators related to control actions (population surveyed, tests performed, treatment coverage) and epidemiological actions (positivity, parasite load, other helminthiases). Results: Health Regions II, III, IV, V and XII, which are traditionally endemic, registered higher average percentages for control actions (population surveyed [6.5%, 6.0%, 2.0%, 12.0%, and 13.0%], tests performed [75.0%, 75.5%, 74.0%, 74.0%, and 68.5%], and treatment coverage [71.0%, 82.5%, 82.0%, 91.0%, and 73.0%], respectively), and higher average percentages for epidemiological variables (positivity [3.5%, 8.0%, 1.0%, 2.0%, and 6.5%], high parasite load [0.1%, 0.7%, 0.02%, 0.03%, and 0.5%], and other helminthiases [4.0%, 11.0%, 4.0%, 6.0%, and 8.0%], respectively). Conclusion: control actions need to be expanded in traditionally endemic regions.

Schistosomiasis/epidemiology , Information Systems , Epidemiologic Factors , Endemic Diseases/statistics & numerical data , Neglected Diseases/epidemiology , Epidemiology, Descriptive , Public Health Surveillance