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1.
Espaç. saúde (Online) ; 23: 1-12, junho de 2022. ilus.
Article in Portuguese | LILACS | ID: biblio-1373165

ABSTRACT

As tecnologias de cuidado abordadas durante os cuidados paliativos devem ser direcionadas à promoção da qualidade de vida de crianças e adolescentes. Descrever as aplicações de tecnologias assistenciais disponíveis no cuidado à criança e ao adolescente no contexto neuropaliativo. Estudo de abordagem mista, com coleta de dados on-line com profissionais de enfermagem. As tecnologias analisadas foram: musicoterapia, massagem, utilização de animais, brinquedos terapêuticos, auriculoterapia, exercícios físicos, aparelhos de mídias e a participação da família. Foi realizada uma análise descritiva para detectar quais técnicas eram utilizadas no contexto terminal de crianças e adolescentes, consequentemente o efeito gerado no paciente. Após esse mapeamento, obteve-se como resultado a utilização da família (24; 80,0%), seguido do brinquedo terapêutico (17; 56,7%), como as principais tecnologias utilizadas. Por fim, ficou explícito que instrumentos de distração anexados à infância, e ao sentimento de lar são os mais utilizados e com resultados positivos no paciente pediátrico


Care technologies addressed during palliative care should be aimed at promoting the quality of life of children and adolescents. To describe the applications of assistive technologies available in the care of children and adolescents in the neuropalliative context. A mixed study was carried out, with online data collection with nursing professionals. The technologies analyzed were: Music therapy, massage, use of animals, therapeutic toys, auriculotherapy, physical exercises, media devices and family participation. A descriptive analysis was carried out to detect which techniques were used in the terminal context of children and teenagers, consequently the effect generated on the patient. After this mapping, the result was the use of the family (24; 80.0%), followed by the therapeutic toy (17; 56.7%), as the main technologies used. Finally, it became clear that distraction instruments attached to childhood and the feeling of home are the most used and with positive results in pediatric patients.


Las tecnologías de cuidado abordadas durante los cuidados paliativos deben estar dirigidas a promover la calidad de vida de los niños y adolescentes. Describir las aplicaciones de las tecnologías de asistencia disponibles en el contexto neuropaliativo. Estudio de enfoque mixto, con recolección de datos en línea con profesionales de enfermería. Las tecnologías analizadas fueron: musicoterapia, masaje, uso de animales, juguetes terapéuticos, auriculoterapia, ejercicios físicos, dispositivos multimedia y participación familiar. Se realizó un análisis descriptivo para detectar qué técnicas se utilizaban en el contexto terminal de niños y adolescentes, consecuentemente el efecto que generaban en el paciente. Después de este mapeo, el resultado fue el uso de la familia (24; 80,0%), seguido del juguete terapéutico (17; 56,7%), como las principales tecnologías utilizadas. Finalmente, quedó claro que los instrumentos de distracción apegados a la infancia y al sentimiento de hogar son los más utilizados y con resultados positivos en pacientes pediátricos.


Subject(s)
Palliative Care , Pediatric Nursing , Quality of Life , Technology , Nurse Practitioners
2.
Rev. bioét. (Impr.) ; 30(1): 82-93, jan.-mar. 2022.
Article in Portuguese | LILACS | ID: biblio-1376482

ABSTRACT

Resumo Este artigo explora vantagens e possíveis desafios bioéticos do uso da inteligência artificial em hospitais. A partir da identificação de desafios no desenvolvimento de sistemas dotados de inteligência artificial (fase pré-hospitalar) e na implementação e capacitação de equipes de saúde (fase hospitalar), analisa-se o papel da abordagem bioética no enfrentamento dessa situação, sobretudo dos comitês de bioética hospitalar. Desse modo, mediante a identificação de desafios de ordem individual - referentes à autonomia, consentimento e privacidade dos pacientes - e coletiva - como a sociedade em geral deve se portar diante das novas tecnologias -, observa-se o papel do Estado na proteção da privacidade do paciente no contexto de utilização da inteligência artificial. Em conclusão, considerando a vulnerabilidade humana perante a tecnologia, entende-se que a regulamentação é um instrumento que, junto com os princípios bioéticos, tenta minimizar os desafios do uso da inteligência artificial em hospitais.


Abstract This paper explores advantages and possible bioethical challenges of using artificial intelligence in hospitals. By identifying challenges both in the development of artificial intelligence systems (pre-hospital phase), its adoption, and training of healthcare teams (hospital phase), it analyzes the role of the bioethical approach in addressing this situation, especially in hospital bioethics committees. Hence, by identifying individual - related to autonomy, consent and patient privacy -, and collective challenges - how society at large should behave before new technologies -, the paper examines the role of the state in protecting patient privacy in contexts where artificial intelligence is used. In conclusion, considering the human vulnerability before technology, regulation is a tool that, anchored in bioethical principles, aims to minimize the challenges concerning artificial intelligence in hospitals.


Resumen Este artículo explora las ventajas y los posibles desafíos bioéticos que plantea el uso de la inteligencia artificial en los hospitales. Con base en la identificación de los desafíos en el desarrollo de sistemas dotados de inteligencia artificial (etapa prehospitalaria) y en la implementación y capacitación de los equipos de salud (etapa hospitalaria), se analiza el papel del enfoque bioético en el enfrentamiento de esta situación, especialmente de los comités de bioética hospitalaria. Por lo tanto, mediante la identificación de los desafíos individuales -relativos a la autonomía, al consentimiento y a la privacidad de los pacientes- y colectivos -cómo debe actuar la sociedad en general ante las nuevas tecnologías-, se observa el papel del Estado en la protección de la privacidad del paciente en el contexto del uso de la inteligencia artificial. En conclusión, teniendo en cuenta la vulnerabilidad humana ante la tecnología, se entiende que la regulación es un instrumento que, junto con los principios bioéticos, trata de minimizar los desafíos del uso de la inteligencia artificial en los hospitales.


Subject(s)
Social Control, Formal , Technology , Bioethics , Artificial Intelligence , State , Hospitals , Human Rights
3.
Rev. SOBECC (Online) ; 27: 1-7, 01-01-2022.
Article in Portuguese | LILACS, BDENF | ID: biblio-1381468

ABSTRACT

Objetivo: Relatar o desenvolvimento e a implementação de um painel de mapa cirúrgico com automação para visualização de informações da cirurgia, equipe, status, riscos e preparo pré-operatório. Método: Relato de experiência sobre o desenvolvimento e a implementação de um painel de visualização do mapa cirúrgico, status, riscos e preparo do paciente que visa melhorar a comunicação multiprofissional e o acompanhamento do workflow de preparo do paciente, em um hospital de grande porte e filantrópico, no município de São Paulo, de agosto de 2021 a fevereiro de 2022. Resultados: Foram quatro fases no processo. Primeira, o entendimento das regras de negócio. Segunda, a identificação dos iconogramas que vão compor o painel. Terceira, o desenvolvimento do produto e o teste de funcionalidades. Quarta, a implementação em ambiente produtivo, com apresentação da tecnologia para equipe médica e enfermagem. Conclusão: O novo painel cirúrgico é colorido, os iconogramas são rapidamente identificados e auxiliam o processo de comunicação, a segurança e a assistência da equipe multiprofissional, facilitando processos de trabalho e intervindo com antecedência em potenciais riscos.


Objective: To report the development and implementation of a surgical map panel with automated view of information about the surgery, team, status, risks and preoperative preparation. Method: Experience report on the development and implementation of a visual panel for surgical map, status, risks and patient preparation that aims to improve multiprofessional communication and follow-up of patient preparation workflow, in a large charity hospital in the city of São Paulo, from August 2021 to February 2022. Results: The process took place in four stages: understanding the business rules; identifying iconograms that would compose the panel; product development and feature testing; implementation in a productive environment, presenting the technology to the medical and nursing staff. Conclusion: The new surgical panel is colored, where iconograms are quickly identified and help in the communication, safety and assistance by the multidisciplinary team, facilitating workflows and allowing early intervention to potential risks.


Objetivo: informar el desarrollo e implementación de un panel de mapa quirúrgico de automatización para ver información sobre la cirugía, el equipo, el estado, los riesgos y la preparación preoperatoria. Método: Informe de experiencia sobre el desarrollo e implementación de un panel de visualización de mapa quirúrgico, estado, riesgos y preparación del paciente destinado a mejorar la comunicación multiprofesional y el monitoreo del flujo de trabajo de preparación del paciente, y su implementación en el área en un grande hospital, filantrópico en el municipio del municipio de São Paulo desde agosto de 2021 hasta febrero de 2022. Resultados: Hubo cuatro fases en el proceso, primero la comprensión de las reglas comerciales, la segunda identificación de los iconogramas que compondrán el panel, el tercer el desarrollo de productos y las pruebas de funcionalidad y la última implementación en el entorno productivo, la presentación de la tecnología al equipo médico y enfermería. Conclusión: El nuevo panel quirúrgico está coloreado, los iconogramas se identifican rápidamente, ayudan al proceso de comunicación, seguridad y asistencia del equipo multiprofesional, facilitando los procesos de trabajo e interviniendo de antemano con riesgos potenciales.


Subject(s)
Humans , Automation , Equipment and Supplies , Patient Safety , Safety , Technology , Nursing
4.
Alerta (San Salvador) ; 5(1): 50-56, ene. 28, 2022.
Article in Spanish | LILACS, BISSAL | ID: biblio-1354461

ABSTRACT

Las tecnologías de información y comunicación suponen un avance para la sociedad. Hoy en día, los dispositivos móviles proveen servicios convenientes para la cotidianidad, facilitando la comunicación, el ocio y las relaciones interpersonales, sin embargo, se describe que su uso excesivo influye en la aparición de síntomas como ansiedad, comportamientos adictivos y alteraciones del sueño. De todos los usuarios de estas tecnologías, los adolescentes son un grupo especialmente afectado, debido al fácil acceso a estas desde edades muy tempranas y la consecuente integración a su vida diaria. Por lo que se pretende determinar el papel del uso de dispositivos móviles en el desarrollo de trastornos del sueño en adolescentes. Pese a sus efectos deletéreos, se ha observado que el uso de estas tecnologías puede ocasionar sensación de bienestar y apoyo social en algunos usuarios, particularmente cuando promueve la interacción con sus pares. El uso excesivo de las tecnologías, en especial horas antes de dormir, se relaciona con un patrón de sueño anómalo, se ha identificado que los trastornos del sueño más prevalentes en los usuarios son el insomnio y la somnolencia diurna excesiva


Information and communication technologies represent an advance for society. Nowadays, mobile devices provide convenient services for everyday life, facilitating communication, leisure and interpersonal relationships, however, it is described that their excessive use influences the appearance of symptoms such as anxiety, addictive behaviors and sleep disturbances. Of all the users of these technologies, adolescents are a particularly affected group, due to the easy access to them from a very early age and the consequent integration into their daily lives. Therefore, it is intended to determine the role of the use of mobile devices in the development of sleep disorders in adolescents. Despite their deleterious effects, it has been observed that the use of these technologies can cause a feeling of well-being and social support in some users, particularly when it promotes interaction with their peers. The excessive use of technologies, especially hours before bed, is related to an abnormal sleep pattern, it has been identified that the most prevalent sleep disorders in users are insomnia and excessive daytime sleepiness


Subject(s)
Sleep Wake Disorders , Technology , Adolescent , Behavior, Addictive , Disorders of Excessive Somnolence , Sleep Initiation and Maintenance Disorders , Anxiety , Sleep , Computers, Handheld
5.
Int. braz. j. urol ; 48(1): 200-201, Jan.-Feb. 2022.
Article in English | LILACS | ID: biblio-1356299

ABSTRACT

ABSTRACT Purpose: The expansion of technology is leading to a paradigm shift in several urological fields (1, 2). In particular, the adoption of lasers within the surgical treatment of patients with benign prostatic hyperplasia (BPH) is considered one of the most relevant innovations (3-5). In this video, we aimed to report our experience with holmium laser for the ablation of the prostate (HoLAP) in patients with obstructive lower urinary tract symptoms (LUTS) due to BPH. Materials and Methods: From 2018 to 2020, 10 patients with obstructive LUTS secondary to BPH were treated at our Institution with HoLAP (120W Holmium laser Lumenis® with Moses® technology). Main inclusion criteria were: 1) International Prostate Symptom Score ≥12; 2) prostate volume ≤65mL, 3) maximal flow rate (Qmax) ≤15ml/s at preoperative non-invasive uroflowmetry. Results: Mean patient age was 65 (range: 59-72) years. Preoperative mean prostate volume was 50 (range: 35-65) mL. Mean operative time was 66 (range: 45-85) minutes with a mean laser time/operative time ratio of 0.51 (range: 0.44-0.60). Voiding symptoms, Qmax and post voiding residual were significantly improved after 3 and 12 months (all p <0.05). No postoperative urinary incontinence was detected. Conclusions: The present findings suggest that HoLAP is a slightly time-spending procedure, thus its use should be limited to prostate volume <70-80mL. However, no postoperative complications were recorded at all. This technique showed to be a safe option in patients with low-intermediate prostate volume, also in patients whose antiaggregant/anticoagulant therapy is maintained.


Subject(s)
Humans , Male , Prostatic Hyperplasia/surgery , Transurethral Resection of Prostate , Laser Therapy , Lasers, Solid-State/therapeutic use , Prostate/surgery , Prostatectomy , Technology , Holmium
6.
Article in Chinese | WPRIM | ID: wpr-928884

ABSTRACT

As an important auxiliary tool for amputees to gain abled limb functions, prosthetic limbs with decoration or feedforward control channel could not meet the needs. In order to enable the prosthesis to deliver the information, includes temperature, pressure, position, shape and so on, a variety of sensory feedback methods have been integrated into the prosthesis. According to the position of the feedback terminal on the human body, the perceptual feedback systems include invasive and noninvasive sensory feedback. This review presents the research progress of these perceptual feedback techniques, and summarizes the problems in the application in artificial limbs. Finally, the development trend of sensory feedback technology in prostheses is prospected.


Subject(s)
Amputees , Artificial Limbs , Feedback, Sensory , Humans , Prosthesis Design , Technology
7.
Article in Chinese | WPRIM | ID: wpr-928875

ABSTRACT

By using Doppler sensor and pressure sensor, the cerebrovascular stroke detector can be used to measure the blood flow velocity and blood pressure of the carotid artery. In this study, a variety of signal conversion and isolation processing techniques are proposed for processing and feature extraction of the output signals from the sensors. Finally, effective signal output waveforms that can be used to evaluate the cerebrovascular hemodynamics index (CVHI) are obtained, and the sound signal outputs that can reflect the change characteristics of blood flow velocity and blood pressure signals are generated, which realizes the application functional requirements of the detector.


Subject(s)
Blood Flow Velocity/physiology , Cerebrovascular Circulation/physiology , Hemodynamics/physiology , Humans , Stroke , Technology
8.
Article in Chinese | WPRIM | ID: wpr-928861

ABSTRACT

Advances in digital pathology technology have enabled pathologists and laboratory physicians to perform quick, easy, accurate and reproducible analysis of digital images of tissues and cells with the aid of electronic screens and software tools, rather than relying solely on traditional optical microscopy observations. The conventional clinical cytology testing practice is to be replaced by a digital workflow, which includes both digital imaging and image analysis. This article provides an overview of the basic principles of digital pathology techniques, the advances of development of device in cytology digital pathology, and their clinical applications in bone marrow morphology, and existing problems and prospects of digital pathology application in hematology.


Subject(s)
Bone Marrow , Image Processing, Computer-Assisted , Microscopy , Software , Technology
9.
Article in Chinese | WPRIM | ID: wpr-928860

ABSTRACT

Physiological parameter monitoring is essential to medical staff to evaluate, diagnose and treat patients in neonatal intensive care unit (NICU). Monitoring in NICU includes basic vital signal monitoring and functional monitoring. Basic vital signal monitoring (including ECG, respiration, SpO2, blood pressure, temperature) is advanced and focus on study of usability, continuity and anti-interference. Functional monitoring (including respiratory function, circulatory function, cerebral function) still focus on study of monitoring precision and reliability. Meanwhile, video monitoring and artifact intelligence have presented well performance on improving monitoring precision and anti-interference. In this article, the main parameters and relevant measurement technology for monitoring critical neonates were described.


Subject(s)
Humans , Infant, Newborn , Intensive Care Units, Neonatal , Monitoring, Physiologic , Reproducibility of Results , Respiration , Technology , Vital Signs
10.
Article in Chinese | WPRIM | ID: wpr-928859

ABSTRACT

The detection and dynamic monitoring of intraocular pressure have important clinical significance for the diagnosis and treatment of glaucoma. The current status of clinical intraocular pressure detection and dynamic intraocular pressure monitoring are reviewed. The technical challenges encountered, and the shortcomings of the existing technology are analyzed, in order to expect better intraocular pressure monitoring technology to be applied to patients.


Subject(s)
Glaucoma/diagnosis , Humans , Intraocular Pressure , Technology , Tonometry, Ocular
11.
Article in Chinese | WPRIM | ID: wpr-928764

ABSTRACT

The ABO blood group system is the most important blood group system in clinical transfusion. Serological technology is a routine method for the identification of ABO blood groups, however, which have some limitations in the identification of complicated ABO samples with weakened antigens or antibodies, abnormal plasma proteins, polyagglutination, or cold agglutinin, etc. With the development of molecular biology technology, ABO blood group gene was cloned, and ABO blood group genotyping technology based on DNA was established. The genotyping technologies with different throughputs such as PCR-SSP, Droplet-AS-PCR, PCR-RFLP, PCR-SBT, SNaPshot, MALDI-TOF MS and NGS have emerged. Genotyping has overcome the limitations of serology, and has become an indispensable method to solve difficult blood type, providing strong support for the correct identification of ABO blood group, and providing guarantee for precision blood transfusion. This review summarizes the progress and application of ABO blood group genotyping methods.


Subject(s)
ABO Blood-Group System/genetics , Blood Grouping and Crossmatching , Genotype , Humans , Polymerase Chain Reaction/methods , Technology
12.
Article in Chinese | WPRIM | ID: wpr-928690

ABSTRACT

OBJECTIVE@#To explore the clinical significance of magnetic resonance imaging water-fat separation (Dixon) technique in patients with multiple myeloma.@*METHODS@#A total of 41 newly diagnosed patients with multiple myeloma who underwent Dixon in The Affiliated Hospital of Qingdao University from April 2019 to April 2021 were included in this study. Patients were divided into observation group and control group according to whether Dixon performance was normal or not. The differences of clinical data and fat fraction (FF) between the two groups were compared. The correlation between FF and clinical data, disease stages and differences before and after treatment were also compared. The receiver operator characteristic curve of patients was drawn to analyze the diagnostic value of FF combined with serum alkaline phosphatase for bone destruction in patients with multiple myeloma.@*RESULTS@#Among the 41 patients, there were 12 cases in the control group and 29 cases in the observation group. There was no significant difference in age and sex between the two groups. In the observation group, β2-microglobulin concentration and M protein were significantly higher than those in the control group, while serum alkaline phosphatase and FF were lower (P<0.05). In all 41 patients included in the study, there was a significant negative correlation between FF value and β2-microglobulin concentration (r=-0.57), and a significant positive correlation between FF value and serum alkaline phosphatase (r=0.31). After treatment, FF value increased, while myeloma cell percentage, β2-microglobulin concentration and M protein decreased in 11 patients who completed 4 cycles of chemotherapy, and the differences before and after treatment were statistically significant (P<0.05). The value of serum alkaline phosphatase combined with FF value in predicting bone destruction is higher than that of FF value or serum alkaline phosphatase alone.@*CONCLUSION@#Dixon's different imaging manifestations can reflect the severity of the disease. FF value is correlated with clinical examination results and R-ISS staging, and there is a significant difference before and after treatment. Serum alkaline phosphatase combined with FF value is better than two indicators alone in predicting bone destruction.


Subject(s)
Humans , Magnetic Resonance Imaging , Multiple Myeloma/diagnostic imaging , Technology , Water
13.
Article in Chinese | WPRIM | ID: wpr-928439

ABSTRACT

OBJECTIVE@#To analyze the genomic variation characteristics of fetal with abnormal serological screening, and to further explore the value of copy number variation (CNV) detection technology in prenatal diagnosis of fetal with abnormal serological screening.@*METHODS@#7617 singleton pregnant women who underwent amniocentesis for prenatal diagnosis solely due to abnormal Down's serological screening were selected. According to the results of serological screening, the patients were divided into high risk group, borderline risk group and single abnormal multiple of median (MOM) group. CMA and CNV-Seq were used to detect the copy number variation of amniotic fluid cell genomic DNA and combined with amniotic fluid cell karyotype analysis for prenatal diagnosis. Outpatient revisit combined with telephone inquiry was used for postnatal follow-up.@*RESULTS@#Among 7617 amniotic fluid samples, aneuploidy was detected in 138cases (1.81%) by CMA and CNV-Seq, 9 cases of aneuploid chimerism were detected by amniotic fluid cell karyotype analysis, and 203 cases of fetus carrying pathogenic and likely pathogenic CNV (P/LP CNV) were detected, the variant of uncertain significance (VUS) was detected in 437 cases (5.7%), the overall abnormal detection rate was 10.33%. The detection rate of aneuploidy by CMA and CNV-Seq in three group were 123 cases (2.9%), 13 cases (1.3%) and 2 cases (0.4%), respectively,and showing no significant difference (χ 2=7.469, P=0.024). The detection rate of pathogenic and likely pathogenic CNV in three group were 163cases (2.6%); 24 cases (2.6%) and 16 cases (3.3%), respectively, and showing no significant difference (χ 2=0.764, P=0.682). The CMA reported 2.9% (108/3729)P/LP CNV, and CNV-seq reported 2.4% (95/3888)P/LP CNV, both tests showed similar detective capabilities (χ 2=1.504, P=0.22).The most popular P/LP CNV in this cohort were Xp22.31 microdeletion, 16p13.11 microduplication /microdeletion, 22q11.21 microduplication /microdeletion. In fetuses with P/LP CNV CNV, 59 fetuses were terminated pregnancy, and 32 of 112 fetuses born had abnormal clinical manifestations. Non-medically necessary termination of pregnancy occurred in 11 fetuses carrying VUS CNV, 322 fetuses carrying VUS CNV were born, 4 of them presented abnormal clinical manifestations.@*CONCLUSION@#Compared with the traditional chromosome karyotype, CMA and CNV-Seq can improve the detection rate of pathogenic and likely pathogenic CNV. CMA and CNV-seq can be used for first tier diagnosis of pregnant women in the general population with abnormal Down's serological screening.


Subject(s)
Amniotic Fluid , Aneuploidy , Chromosome Aberrations , DNA Copy Number Variations , Female , Genomics , Humans , Pregnancy , Pregnancy Trimester, Second , Pregnant Women , Prenatal Diagnosis/methods , Technology
14.
Article in Chinese | WPRIM | ID: wpr-928306

ABSTRACT

OBJECTIVE@#To explore the clinical effect of the modified Topping-off technique in the treatment of multiple lumbar degenerative diseases.@*METHODS@#From October 2019 to May 2020, 42 patients who underwent modified Topping-off operation (modified Topping-off group) and 42 patients who underwent multilevel total laminectomy and interbody fusion with screw rod system internal fixation (whole laminectomy group) were observed and analyzed. There were 15 males and 27 females in the modified Topping-off group, aged from 28 to 80 years old, with an average of (59.57±11.85)years old. There were 14 males and 28 females in the whole laminectomy group, aged from 45 to 82 years old, with an average of (64.26±9.19) years old. Visual analogue scale (VAS) and Oswestry Disability Index (ODI) were evaluated before operation, 1 week, 6 weeks and 12 weeks after operation. The intraoperative blood loss, incision length, operation time, postoperative drainage, weight-bearing time, hospitalization time, intervertebral space height, intervertebral foramen height and lumbar mobility were statistically analyzed.@*RESULTS@#All patients were followed up for 12 weeks. The intraoperative blood loss and postoperative drainage in the modified Topping-off group were significantly less than those in the whole lamina group (P<0.05). The incision length, operation time, weight-bearing time and hospital stay in the modified Topping-off group were shorter than those in the whole lamina group(P<0.05). There were significant differences in intervertebral space height, intervertebral foramen height and lumbar mobility between the two groups at 12 weeks after operation(P<0.05). The modified Topping-off group had significantly lower VAS 1, 6, 12 weeks after operation and ODI 12 weeks after operation compared with rhose before operation. The VAS at 1, 6, 12 weeks in the whole lamina group were significantly lower those that before operation(P<0.05). The ODI at 12 weeks in the whole lamina group were significantly lower than those before operation(P<0.01). There were significant differences in VAS scores between the two groups at 1 week, 6 weeks and 12 weeks after operation(P<0.01). There was significant difference in ODI between the two groups 12 weeks after operation(P<0.01).@*CONCLUSION@#The application of modified Topping-off technique in the treatment of multi segmental lumbar degenerative diseases can reduce the total length of fusion segments, avoid or slow down the degeneration of adjacent segments, and has a positive effect on maintaining the normal movement of the spine.


Subject(s)
Adult , Aged , Aged, 80 and over , Bone Screws , Female , Humans , Lumbar Vertebrae/surgery , Lumbosacral Region , Male , Middle Aged , Spinal Fusion/methods , Technology
15.
Article in Chinese | WPRIM | ID: wpr-928264

ABSTRACT

OBJECTIVE@#To investigate the effect of computer navigation gap balance technology on the recovery of lower limb function after total knee arthroplasty.@*METHODS@#The clinical data of 106 patients with knee osteoarthritis (OA) who underwent total knee arthroplasty from July 2018 to June 2019 were analyzed retrospectively. They were divided into measurement osteotomy group and space balance group according to different osteotomy techniques during total knee arthroplasty. There were 61 cases in osteotomy group, 24 males and 37 females;The age ranged from 45 to 77(63.35±4.26) years;According to K-L classification, 41 cases were grade Ⅲ and 20 cases were grade Ⅳ. intraoperative measurement osteotomy was performed. There were 45 cases in the gap balance group, 17 males and 28 females;Age 45 to 78(64.03±4.31) years;According to K-L classification, 29 cases were classified as grade Ⅲ and 16 cases as grade Ⅳ. computer navigation gap balance technology was implemented. The amount of intraoperative bleeding, operation time, incision length, hospital stay and postoperative complications were compared between two groups. The clinical efficacy was evaluated by Knee Society score(KSS) before operation and 12 months after operation.@*RESULTS@#Total of 106 patients were followed up for 12 to 18(20.38±3.25) months. There were significant differences in intraoperative bleeding and operation time between two groups(P<0.05). There was no significant difference in incision length and hospital stay between the two groups(P>0.05). At 12 months after operation, the total score of KSS in the gap balance group (173.59±14.50) was better than that in the osteotomy group (164.95±12.10)(P<0.05). There were no serious complications of poor prosthesis loosening between two groups during follow-up, and there was no significant difference in the incidence of other complications between two groups(P>0.05).@*CONCLUSION@#The application of computer navigation gap balance technology in total knee arthroplasty is conducive to the recovery of lower limb function in patients with OA, and there are no serious adverse complications and high safety.


Subject(s)
Aged , Arthroplasty, Replacement, Knee , Computers , Female , Humans , Knee Joint/surgery , Knee Prosthesis , Lower Extremity , Male , Middle Aged , Osteoarthritis, Knee/surgery , Retrospective Studies , Technology , Treatment Outcome
16.
Article in Chinese | WPRIM | ID: wpr-928238

ABSTRACT

Brain-computer interface (BCI) is a revolutionary human-computer interaction technology, which includes both BCI that can output instructions directly from the brain to external devices or machines without relying on the peripheral nerve and muscle system, and BCI that bypasses the peripheral nerve and muscle system and inputs electrical, magnetic, acoustic and optical stimuli or neural feedback directly to the brain from external devices or machines. With the development of BCI technology, it has potential application not only in medical field, but also in non-medical fields, such as education, military, finance, entertainment, smart home and so on. At present, there is little literature on the relevant application of BCI technology, the current situation of BCI industrialization at home and abroad and its commercial value. Therefore, this paper expounds and discusses the above contents, which are expected to provide valuable information for the public and organizations, BCI researchers, BCI industry translators and salespeople, and improve the cognitive level of BCI technology, further promote the application and industrial transformation of BCI technology and enhance the commercial value of BCI, so as to serve mankind better.


Subject(s)
Brain/physiology , Brain-Computer Interfaces , Electroencephalography , Humans , Technology , User-Computer Interface
17.
Article in Chinese | WPRIM | ID: wpr-928215

ABSTRACT

Brain-computer interaction (BCI) is a transformative human-computer interaction, which aims to bypass the peripheral nerve and muscle system and directly convert the perception, imagery or thinking activities of cranial nerves into actions for further improving the quality of human life. Magnetoencephalogram (MEG) measures the magnetic field generated by the electrical activity of neurons. It has the unique advantages of non-contact measurement, high temporal and spatial resolution, and convenient preparation. It is a new BCI driving signal. MEG-BCI research has important brain science significance and potential application value. So far, few documents have elaborated the key technical issues involved in MEG-BCI. Therefore, this paper focuses on the key technologies of MEG-BCI, and details the signal acquisition technology involved in the practical MEG-BCI system, the design of the MEG-BCI experimental paradigm, the MEG signal analysis and decoding key technology, MEG-BCI neurofeedback technology and its intelligent method. Finally, this paper also discusses the existing problems and future development trends of MEG-BCI. It is hoped that this paper will provide more useful ideas for MEG-BCI innovation research.


Subject(s)
Brain/physiology , Brain-Computer Interfaces , Electroencephalography , Humans , Imagery, Psychotherapy , Magnetoencephalography , Technology
18.
Article in Chinese | WPRIM | ID: wpr-928085

ABSTRACT

With the rice-steamed Rehmanniae Radix unearthed from the tomb of Haihunhou in the Western Han Dynasty as the re-ference, the present study evaluated the quality of Rehmanniae Radix and investigated the processing technology of rice-steamed Rehmanniae Radix to lay the foundation for the research on rice-steamed Rehmanniae Radix products. With catalpol and rehmannioside D as the investigation indexes, the quality and grade of Rehmanniae Radix from different producing areas were evaluated with the methods in 2020 edition of Chinese Pharmacopoeia. UPLC method was established for the determination of catalpol and rehmannioside D in the rice-steamed Rehmanniae Radix. The effects of steaming time, the amount of supplementary rice, and steaming times in the rice-steamed processing on the quality of products were investigated by L_9(3~4) orthogonal test and multi-index comprehensive balance scoring method combined with the content of catalpol and rehmannioside D and appearance characteristics. At last, the stability of the processing technology was tested. The results showed that the optimal processing technology for rice-steamed Rehmanniae Radix was as follows: Rehmanniae Radix and rice(200 g∶4 g) were steamed twice at atmospheric pressure, four hours each time. The mass fractions of catalpol and rehmannioside D were 0.184% and 0.335%, respectively, and the character score was 6.5. The processing conditions are reaso-nable, stable, and feasible. It can provide a basis for the restoration of the ancient rice-steamed processing technology and references for the development of rice-steamed Rehmanniae Radix products in the future.


Subject(s)
Drugs, Chinese Herbal/pharmacology , Oryza , Plant Extracts , Rehmannia , Technology
19.
Article in Chinese | WPRIM | ID: wpr-928060

ABSTRACT

This study aims to explore the targets of ginsenosides in brain based on drug affinity responsive target stability(DARTS) technology. Specifically, DARTS technology was combined with label-free liquid chromatography tandem mass spectrometry(LC-MS) to screen out the proteins in the brain that might interact with ginsenosides. Based on the screening results, adenylate kinase 1(AK1) was selected for further confirmation. First, the His-AK1 fusion protein was yielded successively through the construction of recombinant prokaryotic expression vector, expression of target protein, and purification of the fusion protein. Biolayer interferometry(BLI) was employed to detect the direct interaction of Rg_1, Re, Rb_1, Rd, Rh_2, F1, Rh_1, compound K(CK), 25-OH-PPD, protopanaxa-diol(PPD), and protopanaxatriol(PPT) with AK1, thereby screening the ginsenoside monomer or sapogenin that had strong direct interaction with the suspected target protein AK1. Then, the BLI was used to further determine the kinetic parameters for the binding of PPD(strongest interaction with AK1) to His-AK1 fusion protein. Finally, molecular docking technology was applied to analyze the binding properties between the two. With DARTS and LC-MS, multiple differential proteins were screened out, and AK1 was selected based on previous research for target verification. Fusion protein His-AK1 was obtained by prokaryotic expression, and the response(nm) of Re, Rg_1, Rd, Rb_1, Rh_1, Rh_2, F1, PPT, PPD, 25-OH-PPD, and CK with His-AK1 was respectively 0.003 1, 0.001 9, 0.042 8, 0.022 2, 0.013 4, 0.037 3, 0.013 9, 0.030 7, 0.140 2, 0.016 0, and 0.040 8. The K_(on), K_(off), and K_D values of PPD and His-AK1 were determined by the BLI as 1.22×10~2 mol~(-1)·L·s~(-1), 1.04×10~(-2) s~(-1), 8.52×10~(-5) mol·L~(-1). According to the molecular docking result, PPD bound to AK1 with the absolute value of the docking score of 3.438, and hydrogen bonds mainly formed between the two. Thus, AK1 is one of the protein action sites of ginsenosides in the brain. The direct interaction between ginsenoside metabolite PPD and AK1 is the strongest.


Subject(s)
Brain/metabolism , Chromatography, Liquid , Ginsenosides , Molecular Docking Simulation , Technology
20.
Article in Chinese | WPRIM | ID: wpr-928048

ABSTRACT

The present study explored the drying effect of new spiral vibration drying technology on Chinese medicinal pills with Liuwei Dihuang Pills, Zhuanggu Guanjie Pills, and Muxiang Shunqi Pills as model drugs. With the drying uniformity, drying time, energy consumption, pill split, dissolution time, and change of index components as evaluation indicators, the drying effect of spiral vibration drying technology on model drugs was evaluated and compared with traditional drying methods, such as hot air drying and vacuum drying in the oven. The dynamic changes of moisture in Liuwei Dihuang Pills with different drying time were investigated. Compared with the traditional drying methods in the oven(hot air drying and vacuum drying) at 80 ℃, the spiral vibration drying only took 80 min, shortened by 80%, with 10%-13% energy consumed. The results showed that the moisture of Liuwei Dihuang Pills was negatively related to the drying time. By virtue of multi-layer countercurrent drying and super resonant fluidization techniques, the new spiral vibration drying technology can significantly improve the drying quality of Chinese medicinal pills, improve the drying efficiency, and enhance the manufacturing capacity of Chinese medicinal pills. This study is expected to provide references for the innovation and development of new drying technology of Chinese medicinal pills.


Subject(s)
China , Desiccation , Physical Therapy Modalities , Technology , Vibration
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