1.
Indian J Exp Biol
; 1995 Jan; 33(1): 38-40
Article
in English
| IMSEAR
| ID: sea-61471
ABSTRACT
Compound 88-765 (4-amino-6-methylthio-1-(2', 2'-diethoxyethyl)-1 H-pyrazolo[3, 4-d]pyrimidine) has shown potent antiallergic activity in experimental models. The compound inhibited the passive cutaneous anaphylaxis (PCA) reaction in rats in dose-dependent manner (5-100 mg/kg, po) by 47 to 87%. In mice it inhibited PCA by 78% at 50 mg/kg, po. It also inhibited mast cell degranulation of normal and passively sensitised rats induced by compound 48/80 and egg albumin, respectively. These effects of Compound 88-765 were comparable with that of disodium cromoglycate (DSCG). The results suggest that compound 88-765 possesses potent antiallergic activity.
Subject(s)
Animals , Anti-Allergic Agents/pharmacology , Cromolyn Sodium/pharmacology , Male , Mast Cells/drug effects , Mice , Passive Cutaneous Anaphylaxis/drug effects , Pyrazoles/pharmacology , Pyrimidines/pharmacology , Rats
2.
Article
in English
| IMSEAR
| ID: sea-20644