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Objective To understand the relationship between green tea drinking and/or garlic consumption and lung cancer.Methods A population-based case-control study was conducted in Ganyu county,Jiangsu province.Epidemiological data including demography,lifestyle,environmental exposures and dietary habits were collected by face-to-face interviews using a standardized questionnaire.Unconditional logistic regression was used to estimate adjusted odds ratios (OR) and their 95% confidence intervals (CI) in both univariate and multivariate analyses.Results Both green tea drinking and garlic consumption were inversely associated with lung cancer and the adjusted ORs were:0.78 (95%CI:0.65-0.95) for green tea,0.79 (95% CI:0.66-0.95) for garlic intake,and 0.69 (95%CI:0.53-0.89) for both,respectively.They also modified the associations of smoking,fried food intake and cooking oil under high-temperature with lung cancer as risk factors.Potential interactions were found between garlic or green tea and the risk factors of lung cancer.Conclusion Both green tea drinking and garlic consumption might serve as protective factors on lung cancer.
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<p><b>OBJECTIVE</b>To estimate the association between overweight, obesity and the risk of breast cancer in Chinese female population.</p><p><b>METHODS</b>Literatures published in China and abroad about overweight, obesity and breast cancer risk among Chinese females were searched. We used "breast cancer", "overweight", "obesity", "weight", "body mass index" and "risk factors" as keywords, to retrieve papers in Chinese literature databases including CNKI, Wanfang and Weipu database. The same strategy was used to retrieve English papers in English literature database including Embase database, PubMed, Science Direct, Elsevier and Cochrane database, supplemented by literature tracing method. Time range was from the founding of each database to April 2012. A total of 124 research papers were collected. Using Stata11.2 software, meta-analysis was conducted, combined odds ratio (OR) and 95% confidence interval (CI) were calculated to estimate the associations between overweight, obesity and the risk of breast cancer in Chinese female population.</p><p><b>RESULTS</b>Eighteen studies were included in meta-analysis, among them 12 studies were in Chinese and 6 were in English, with a number of 7217 cases and 81 605 controls. Results showed a 7.7% increased risk of breast cancer among overweight or obesity women (OR = 1.08, 95%CI: 1.04 - 1.12). Compared with normal BMI women, the OR (95%CI) of overweight or obesity women were 1.07 (1.03 - 1.11) and 1.56 (1.29 - 1.84) before and after the adjustment of menopausal status.</p><p><b>CONCLUSION</b>Overweight, obesity may be important risk factors of breast cancer in Chinese female population. The intervention and control activities may reduce the risk of breast cancer at population level.</p>
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Femenino , Humanos , Pueblo Asiatico , Neoplasias de la Mama , Epidemiología , China , Epidemiología , Obesidad , Epidemiología , Sobrepeso , Epidemiología , Factores de RiesgoRESUMEN
Objective To examine the association between tea drinking and the risk of lung cancer in Chinese population.Methods All relevant published articles in Chinese and English literature database were identified.Meta-analysis was conducted.Combined odds ratio (OR) and 95% confidence interval (CI) were calculated to estimate the associations and dose-response relationship between tea drinking and the risk of lung cancer.Results Twelve studies were included.An inverse association with lung cancer was observed on tea drinkers when compared to non-tea drinkers (OR=0.66,95%CI:0.49-0.89).Conclusion Tea drinking might serve as a protective factor on lung cancer in the Chinese population.
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Objective To examine the relationship between hyperthyroidism and excessive iodine intake from drinking water through epidemiological studies in the iodine excess and the iodine normal villages. Methods Mengzhuang village of Pei county and Xingji village of Pizhou city in Jiangsu province, with median water iodine concentration of 1284.1 μg/L and 77.9 μ/L, respectively,were selected in 2006. Thyroid diseases of all local residents in the two villages were assessed clinically to compare the prevalence and the distribution of hyperthyroidism. Results A total of 17 471 residents were recruited from the iodine excess village, 26 of them were diagnosed with hyperthyroidism. The prevalence of hyperthyroidism was 1.49‰, 0.75‰ (7/9264) in male,2.32‰( 19/8207) in female, and the age-standardized prevalence was 1.48‰. A total of 12 765 residents were recruited from the iodine normal village, among them 27 residents were diagnosed with hyperthyroidism. The prevalence of hyperthyroidism was 2.12‰, 0.96‰(7/6823) in male, 3.26‰(20/5942) in female, and the agestandardized prevalence was 2.02‰. The prevalence and age-standardized prevalence was significantly lower in the iodine excess village than those in the iodine normal village (u = 2.88, 2.89; all P < 0.01). The prevalence of hyperthyroidism was lower among females in the iodine excess village (2.32‰) than that in the iodine normal one (3.37‰, u = 2.89, P < 0.01). Residents aged 20 - 50 years had higher prevalence of hyperthyroidism[(19.36 -38.96 )/10 000]in the two villages. The proportion of Graves diseases was 50.00% (13/26) in the iodine excessvillage, higher than that in the iodine normal village[29.41%(5/17) , χ2 = 5.853, P < 0.01]. Conclusions Chronic excessive iodine intake does not increase the chance of suffering from hyperthyroidism. On the contrary, the prevalence of hyperthyroidism in the iodine excess village decreases significantly compared with that of the iodine normal village. The prevalence is higher among females.
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Objective To examine HIV prevalence and related risk factors among men who have sex with men(MSM) in Chongqing, and to explore the feasibility of using respondent-driven sampling (RDS) in the survey. Methods Based on results from formative research, a RDS survey was designed and conducted to collect demographic, behavioral and serologic data. RDSAT was used to calculate point estimation and confidence intervals. SPSS was used for bi-variate analysis using RDSAT exported weighed data. NETDRAW was used to draw network diagram. Results Among 617 subjects recruited, the adjusted HIV and syphilis prevalence rates were 16.8% and 10.9%, respectively. 73.0% of the subjects were 20 to 29 years old and 72.9% were officially registered residents of Chongqing. 83.4% were single, with the proportion of students the highest, accounting for 24.6%. During the last six months, 83.4% of them reported ever having anal sex, and 54.0% reported having unprotected anal sex. Conclusion This survey confirmed that Chongqing had a higher reported HIV prevalence among MSM than from other Chinese cities. Comprehensive intervention services were required to address this alarmingly high prevalence, with focus on intervention through internet and those having syphilis infection. RDS seemed one of the effective ways of recruiting hidden MSM populations in Chongqing which had a large population of active MSM who did not frequently visit MSM venues as compared with snowball method.
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<p><b>OBJECTIVE</b>To understand the cognition of methadone maintenance treatment (MMT) and to explore the factors associated with the coverage of MMT, among the community-based drug users in Dongguan, Guangdong province.</p><p><b>METHODS</b>In 2008, respondent-driven sampling was applied to recruit community-based drug users in Dongguan. A structured questionnaire was used for a face to face interview. RDSAT was applied to adjust the estimates and the results from bivariate analysis. SPSS was used for multivariate analysis.</p><p><b>RESULTS</b>A total of 303 drug users were recruited within a 15-week period. The coverage of MMT program was 8.4% (95%CI: 3.4 - 16.5). 62.9% of the drug users had heard of MMT, of which 80.8% had not been enrolled at MMT mainly for the following reasons: fear of being arrested (25%), being not familiar with the application process (18.9%), no certification of domiciliary register and or ever being in detoxification center (18.7%) and thinking poorly of MMT (18.3%). Multiple logistic regression model indicated that those who were local residents (OR = 22.5, 95%CI: 6.6 - 75.7) and whose effect of MMT being evaluated as positive (OR = 24.1, 95%CI: 6.3 - 91.6) were more likely to be enrolled at the MMT program.</p><p><b>CONCLUSION</b>Community-based drug users had some irrational cognition on MMT program. Dissemination and sharing of information on MMT should be strengthened through media and existing social network among drug users. More concern should be paid to the people who were on migration when making policy to improve the coverage of MMT.</p>
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Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven , Cognición , Consumidores de Drogas , Psicología , Conocimientos, Actitudes y Práctica en Salud , Metadona , Usos Terapéuticos , Tratamiento de Sustitución de Opiáceos , Aceptación de la Atención de Salud , Centros de Tratamiento de Abuso de Sustancias , Encuestas y CuestionariosRESUMEN
<p><b>OBJECTIVE</b>To understand the HIV epidemic and its correlation among the community-based drug users in Dongguan, Guangdong province.</p><p><b>METHODS</b>In 2008, 13 drug users were identified as seeds in Dongguan. Respondent driven sampling was applied to recruit community-based drug users. A structured questionnaire was used for a face to face interview. Intravenous blood samples were collected for the measurement of HIV, HCV and syphilis antibodies. RDS analysis tool (RDSAT) was applied for adjusting the estimates and bivariate analysis.</p><p><b>RESULTS</b>A total of 303 drug users were recruited within 15 weeks and 300 blood samples were collected. After RDSAT adjustment, the prevalence rates of HIV, HCV and syphilis were 14.7% (95%CI: 6.1% - 25.4%), 63.2% (95%CI: 55.7% - 71.7%), and 4.7% (95%CI: 1.8% - 8.2%) respectively. The HIV prevalence rates among those who were HCV seropositive, migration, younger than 26 years at their first drug use, and ever shared needles or syringes were 22.9% (95%CI: 10.8% - 37.0%), 26.9% (95% CI: 11.4% - 44.9%), 19.9% (95%CI: 8.3% - 35.7%), and 29.1% (95%CI: 12.3% - 45.1%) respectively. The proportions of the drug users who were enrolled at methadone maintenance treatment (MMT) of local residency, migration were 20.9% (95%CI: 4.1% - 44.6%), 2.3% (95%CI: 0.0% - 7.0%) respectively.</p><p><b>CONCLUSION</b>The HIV epidemic among the community-based drug users in Dongguan is serious. Drug users who are HCV seropositive, migration, younger than 26 years at their first drug use, and ever shared needles or syringes are more likely to be HIV seropositive.</p>
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Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven , China , Epidemiología , Consumidores de Drogas , Infecciones por VIH , Epidemiología , Homosexualidad Masculina , Prevalencia , Asunción de Riesgos , Abuso de Sustancias por Vía Intravenosa , Epidemiología , Sexo InseguroRESUMEN
<p><b>OBJECTIVE</b>To explore the current status of HIV infection and HIV-related knowledge, attitude and practice (KAP) among men who have sex with men (MSM) in 14 cities in China.</p><p><b>METHODS</b>A cluster sampling method was administrated and 14 large or medium cities were selected. The respondent-driven sampling (RDS) was also used to conduct a questionnaire survey in 6101 MSM. Blood specimens were collected for HIV and syphilis testing.</p><p><b>RESULTS</b>A total of 6101 MSM were selected and investigated, with an HIV infection rate of 6.3% (384/6101) and a syphilis infection rate of 14.0% (854/6101). The proportion of MSM knowing correct HIV/AIDS knowledge was 59.7% (3644/6101); 6.2% (378/6101) and 11.2% (683/6101) of the respondents ever had buying sex or selling sex in the last six months respectively; the proportion of consistent condom-using each time while with male partners in the last month was 39.2% (2392/6101). The proportion of condom-using while with male partners was 65.2% (3978/6101) in the last time among MSM.</p><p><b>CONCLUSION</b>A high HIV infection rate was observed among MSM with limited HIV/AIDS awareness and high risk behaviors. It is necessary to initiate a rapid response to prevent HIV spreading in MSM.</p>
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Humanos , Masculino , Síndrome de Inmunodeficiencia Adquirida , Epidemiología , China , Epidemiología , Análisis por Conglomerados , Conocimientos, Actitudes y Práctica en Salud , Homosexualidad Masculina , Psicología , Incidencia , Asunción de Riesgos , Encuestas y Cuestionarios , Sexo InseguroRESUMEN
Objective This study assessed the main factors associated with HIV infection among men having sex with men(MSM),in order to provide evidence for future intervention. Methods A case-control study was conducted among HIV cases identified at the MSM survey in Nanjing, Suzhou and Yangzhou cities from May to July in 2008. Each HIV case was matched by 4 HIV negative MSM who participated consecutively right after the HIV case was identified at the same survey, same time and in the same city. A national core MSM survey questionnaire was used with addition of variables of local interest. Fitting conditional logistic regression model was applied for univariate and multivariate analysis. Results During the survey, 62 HIV positive cases were identified and 248 controls were matched. Data from univariate analysis showed that, inconsistent condom use, syphilis infection, self reported sexually transmitted infection (STI) symptoms and/or signs, unprotected anal sex (UAI) were risk factors, with OR values of 5.56(95%CI: 1.82-16.96), 2.19(95%CI: 1.18-4.05), 2.50(95%(CI: 1.13-5.50) and 3.13 (95%CI: 1.64-5.98) respectively. Online cruising and receptive anal sex were protective factors with OR values as 0.47(95%CI: 0.22-0.998) and 0.67(95% CI: 0.23-1.97). Through multivariate analysis, it was found that syphilis, age of having experienced first insertive sexual intercourse and UAI were risk factors to HIV transmission, with OR values of 2.28 (95%CI: 1.05-4.94), 4.16 (95%CI: 1.63-10.66) and 1.11 (95% CI: 1.04-1.18) respectively. Compared with non-anal sex, bisexual (OR=0.41,95%CI: 0.18-0.97) behavior seemed a protected factor. Conclusion Syphilis infection, UAI and self reported STI symptoms and/or signs were risk factors related to HIV transmission while bisexual seemed a protective factor.
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<p><b>OBJECTIVE</b>To understand the infected status of human immunodeficiency virus (HIV), sexually transmitted disease (STD) and relative risk behaviors of men who have sex with men (MSM) in Beijing.</p><p><b>METHODS</b>Respondent-driven sampling (RDS) was adopted to recruit target population and to conduct behavior and serological studies among MSM. RDSAT 5.5 was used to analyze data.</p><p><b>RESULTS</b>Among 427 MSM, the age distribution was as follows: below 30 and less than 35 were 65.4% and 81.0% respectively. 69.2% (95% CI: 63.9-75.5) of them had 12 years or less of education. 73.3% (95% CI: 66.7-79.8) of them were non-Beijing registered residents. The urban and rural registered residents almost accounted for half of all the recruits. HIV positive rate was 4.6% (95% CI: 2.2-7.6) while 56.3% (95% CI: 50.9-62.5) of them reported having had bisexual sex preference. Only 14.8% (95% CI: 10.8-19.6) of them had ever had HIV test, while 22.8% (95% CI: 18.7-27.8) reported ever having had STDs. 55.3% (95% CI: 49.3-61.9) and 55.1% (95% CI: 48.7-61.3) of them had unprotected insert and receptive anal sex over the last 6 months.</p><p><b>CONCLUSION</b>Data from the HIV positive rate showed that there was a trend of increase among MSM in Beijing which called for urgent care to them.</p>
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Adulto , Humanos , Masculino , Adulto Joven , China , Epidemiología , Estudios Epidemiológicos , Infecciones por VIH , Epidemiología , Homosexualidad Masculina , Asunción de Riesgos , Enfermedades de Transmisión Sexual , Epidemiología , Sexo Inseguro , Población UrbanaRESUMEN
<p><b>OBJECTIVE</b>To evaluate the impact of universal salt iodization using monitoring data on correctional status of iodine deficiency and hospitalized thyroid diseases.</p><p><b>METHODS</b>Retrospective survey was conducted to collect medical records of hospitalized thyroid disease cases. Routine monitoring data on population iodine nutrition status and goiter prevalence were analyzed.</p><p><b>RESULTS</b>The coverage of adequately iodized salt was consistently above 95%. Hospitalization rate of thyroid diseases rose steadily, and peaked at 54.5 per 100,000. The proportion of hospitalized thyroid disease among hospitalized diseases also rose with female and those aged above 40 years old mostly affected. The proportion of hospitalized hyperthyroidism among total hospitalized thyroid disease rose from 13.6% to 34.7%.</p><p><b>CONCLUSIONS</b>Universal salt iodization might eliminate iodine deficiency while other impact still exists. However, the benefits of universal salt iodization should be far overweight the adverse effects.</p>
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Femenino , Humanos , Masculino , China , Epidemiología , Yodo , Usos Terapéuticos , Cloruro de Sodio Dietético , Usos Terapéuticos , Enfermedades de la Tiroides , EpidemiologíaRESUMEN
<p><b>OBJECTIVE</b>To examine the significance of crossover analysis in gene-environmental interaction studies.</p><p><b>METHODS</b>Through elaboration of a case-control study on the increased risk of venous thrombosis in oral-conceptive users who were carriers of factor V Leiden mutation, core information from 2 x 4 crossover table were analyzed and compared with stratified analysis and 'case only' study.</p><p><b>RESULTS</b>Different models (additive or multiplicative) in analyzing gene-environmental interaction yielded different results. The result of interaction based on multiplicative model was 1.35 (P > 0.05), compatible with that of stratified analysis and case only study. Calculated by crossover analysis based on additive model, synergy index S(S), attributable proportion of interaction (AP) and relative excess risk of interaction (RERI) appeared to be 3.90, 72.24%, 25.08 (P > 0.05) respectively.</p><p><b>CONCLUSION</b>Crossover analysis should further be applied in gene-environmental interaction studies.</p>