RESUMEN
Objective To observe the safety and feasibility of gelatin sponge-prothrombin-iohexol for blocking needle path of CT-guided percutaneous liver biopsy.Methods Totally 101 patients who underwent CT-guided needle biopsy of liver due to unexplained liver diseases,cirrhosis or space-occupying lesions of liver with coagulation dysfunction were retrospectively analyzed.After biopsy,the puncture needle path was blocked with gelatin sponge-prothrombin-iohexol.The effect and complications of puncture,also patients'coagulation and liver function indicators before and after puncture were observed.Results Successful puncture and sampling were performed in all 101 cases,with both technical success rate and adequacy of histological specimens of 100%.Accurate pathological diagnose was acquired in all 101 cases.Complications including mild pain at the puncture site,penetration of the blocking agent into the liver capsule or subcutaneous tissue were observed in a total of 18 cases(18/101,17.82%),while no severe complication such as bleeding,pneumothorax or bile duct injury occurred.No significant difference of coagulation nor liver function indicators was found before and after CT-guided needle biopsy(all P＞0.05).Conclusion Gelatin sponge-prothrombin-iohexol were safe and reliable for blocking needle path of percutaneous liver biopsy,which could reduce complications such as bleeding.