Etiopatogenia e tratamento da osteonecrose dos maxilares induzida por medicamentos: aspectos essenciais ao dentista / Etiopathogenesis and treatment of medication-related osteonecrosis of the jaw: essential aspects for the dentist

A osteonecrose dos maxilares induzida por medicamentos (MRONJ) caracteriza-se por exposição óssea ou osso que pode ser sondado através de fístula intra ou extraoral, em região maxilofacial, e que não cicatriza dentro de oito semanas. A MRONJ é uma condição rara e debilitante que pode causar dor, disfagia e odor desagradável na cavidade oral, afetando pacientes com histórico ou sob uso contínuo de terapia antirreabsortiva, isolada ou associada a imunomoduladores ou drogas antiangiogênicas, mas sem histórico de radioterapia nos maxilares. O objetivo desta revisão narrativa de literatura é compilar os principais aspectos sobre a etiopatogenia da MRONJ e as opções terapêuticas disponíveis. A etiologia da MRONJ é multifatorial, complexa, e não está totalmente compreendida, não havendo um tratamento definitivo, mas diversas modalidades terapêuticas que visam o controle da dor e da progressão da osteonecrose. Conclui-se com essa revisão que o entendimento da etiopatogenia da MRONJ pelo cirurgião-dentista lhe permite adotar medidas preventivas, bem como o conhecimento das modalidades terapêuticas disponíveis lhe possibilita oferecer o manejo adequado para seu paciente, conforme o estágio da doença.

Medication-related osteonecrosis of the jaw (MRONJ) is characterized by exposed bone or bone that can be probed through an intra or extraoral fistula, in the maxillofacial region, which does not heal within eight weeks. MRONJ is a rare and debilitating condition that can cause pain, dysphagia and unpleasant odor in the oral cavity, affecting patients with a history or continuous use of antiresorptive therapy, alone or associated with immunomodulators or antiangiogenic drugs, but without a history of radiotherapy to the jaws. The aim of this narrative literature review is to compile the main aspects about the etiopathogenesis of MRONJ and the available therapeutic options. The etiology of MRONJ is multifactorial, complex, and is not fully understood, with no definitive treatment, but several therapeutic modalities that aim to control pain and the progression of osteonecrosis. It is concluded from this review that the understanding of the etiopathogenesis of MRONJ by the dental surgeon allows him to adopt preventive measures, as well as the knowledge of the therapeutic modalities available allows him to offer the appropriate management for his patient, depending on the stage of the disease.

Angina bolhosa hemorrágica: uma revisão de literatura / Hemorrhagic angina bullosa: a review of the literature

Introdução: A angina bolhosa hemorrágica (ABH) é uma condição rara caracterizada pelo surgimento súbito de bolhas de sangue nas mucosas orais e orofaringe. Objetivo: Este trabalho tem como propósito fornecer uma análise abrangente das características clínicas, etiológicas e histopatológicas da angina bolhosa hemorrágica, além de abordar métodos de diagnóstico e opções de tratamento. Materiais e métodos: Foi realizada uma busca por artigos científicos publicados de 2010 a 2023, nas bases de dados Scientific Electronic Library Online (SciELO), US National Library of Medicine (PubMed) e ScienceDirect. Foram coletados artigos em inglês e português utilizando as palavras-chave "angina bolhosa hemorrágica", "estomatite bolhosa hemorrágica benigna", "hemorrhagic bullous angina" e "benign hemorrhagic bullous stomatitis". Conclusão: A ABH é escassamente documentada na literatura, com muitos dados ausentes ou subnotificados. Embora seja uma condição benigna com rápida evolução espontânea, o procedimento diagnóstico deve ser rigoroso para descartar outras possíveis lesões.

Introduction: Bullous hemorrhagic angina (ABH) is a rare condition characterized by the sudden appearance of blood blisters on the oral mucosa and oropharynx. Objective: This work aims to provide a comprehensive analysis of the clinical, etiological and histopathological characteristics of hemorrhagic bullous angina, in addition to addressing diagnostic methods and treatment options. Materials and methods: A search was carried out for scientific articles published between 2010 and 2023, in the Scientific Electronic Library Online (SciELO), US National Library of Medicine (PubMed) and ScienceDirect databases. Articles were found in English and Portuguese using the keywords "hemorrhagic bullous angina", "benign herrhagic bullous stomatitis", "hemorrhagic bullous angina" and "benign herrhagic bullous stomatitis". Conclusion: ABH is scarcely documented in the literature, with many data missing or underreported. Although it is a benign condition with rapid spontaneous evolution, the diagnostic procedure must be rigorous to rule out other possible lesions.

Necrotizing sialometaplasia: systematic review and meta analyses over the past 46 years

Objectives: The aim of this study was to characterize the main characteristics of this disease in relation to diagnosis, clinical aspects, progression and treatment as well as correlating them with remission time. Material and Methods: A systematic search was performed following the guidelines given by PRISMA and the Joanna Briggs Institute. PubMed, Web of Science and Scopus were the databases used. Results: The final analysis resulted in 108 articles with 173 clinical cases. The longest remission time for signs and symptoms (>7 weeks) was registered among male patients (p = 0.02) and outside the oral cavity; however no significant correlation was observed (p>0.05). A high risk of bias was the most common rating among the articles analyzed (55%); followed by moderate (27%) and low (18%). The lack of standardization in clinical case report descriptions made it difficult to gain a thorough knowledge of the essential characteristics of the NS patho-logical processes. Conclusion: It is recommended that publications follow the standards recommended by the literature; in addition, studies using advanced technologies to better understand NS's pathological path are recommended so as to propose effective treatments for this disease. (AU)

Recurring basal cell carcinoma involvingexclusively intra-oral mucosa: a case report

Basal cell carcinoma (BCC) is the most common skin cancer, but oral involvement is extremely rare. Here, we showed a case of a 71-year-old Caucasian male patient presenting an asymptomatic submucosal nodule in the left buccal mucosa on the same side of a previous BCC skin lesion. Intraoral examination revealed a circumscribed sessile and fibrous mass covered by normal mucosa. An incisional biopsy was performed. Microscopically, the lesion showed uniform, ovoid, dark-staining basaloid cells with medium-sized nuclei and little cytoplasm arranged in islands and strands, invading the underlying connective tissue. These islands demonstrated palisading of the peripheral cells and occasionally central areas with epidermoid differentiation. The final diagnosis was nodular basal cell carcinoma. Although uncommon, recurrent BCC may occur in the oral cavity. (AU)

Stomatological profile of elderly patients who received dental care at a reference Hospital of Belo Horizonte, Minas Gerais - Brazil: a cross-sectional study

Aim: The aim of this study was to draw a stomatological profile of elderly patients treated at the Stomatology Service of a referral hospital in the city of Belo Horizonte, Minas Gerais ­ Brazil.Methods: Information was collected on the diagnostic hypotheses and definitive diagnoses of the elderly (aged 60 to 98 years) treated at the service, from September 2014 to December 2017. Results: Medical records of 1388 patients were evaluated, and 281 different diagnostic hypotheses were found. For males, there was a higher prevalence in both diagnostic and definitive diagnoses for benign and malignant epithelial neoplasms; In females, there was a higher prevalence, also in the hypotheses and diagnostic definitions, of inflammatory fibrous hyperplasia, related to the use of removable prostheses. Conclusion: Thus, this study evidenced the importance of knowledge about the main alterations that affect the oral cavity of elderly patients, which allows better attention to this population, besides being a pioneering stomatological study in hospital units.

Calcifying odontogenic cyst with AOT-like features: a case report and literature review / Cisto odontogênico calcificante com características adenomatóides: relato de caso e revisão de literatura

Odontogenic lesions are a heterogeneous group of diseases that presents differences in their biological behavior and the occurrence of variable inductive interactions. Calcifying odontogenic cyst (COC), or Gorlin's cyst, is a well-recognized example of these lesions. We describe a case of COC with AOT-like areas and highlights its morphological diversity. A 60-year-old pheoderma man presented with a large swelling in the anterior buccal region of the mandible. Panoramic radiography revealed a well-defined, unilocular, radiolucent lesion associated with important root resorption. Complete enucleation of the lesion was performed and the histopathological findings met the criteria for the diagnosis of COC, although the cyst exhibited unusual AOT-like features. The patient has been recurrence free for 6 months after surgery. COCs with AOT-like features are rare, and reflect the multipotentiality and complexity of the inductive effects of the odontogenic epithelium with the ectomesenchyme. Enucleation seems to be the most indicated treatment, similar to classical COC (AU)

As lesões odontogênicas são um grupo heterogêneo de patologias que apresentam diferenças no seu comportamento biológico, e ocorrência de interações indutivas variáveis. O cisto odontogênico calcificante (COC), ou cisto de Gorlin, é um exemplo bem conhecido destas lesões. Descrevemos um caso de COC com áreas adenomatóides e destacamos a sua diversidade morfológica. Paciente do sexo masculino, 60 anos de idade, apresentou um aumento de volume na região anterior da mandíbula. A radiografia panorâmica revelou uma lesão bem definida, unilocular e radiolúcida associada a uma reabsorção radicular importante. A enucleação completa da lesão foi realizada e os achados histopatológicos preencheram os critérios para o diagnóstico de COC, embora o cisto exibisse características adenomatóides pouco usuais. O paciente permanece livre de recidivas durante 6 meses após a cirurgia. Os COCs com características adenomatóides são raros, e refletem a multipotencialidade e complexidade dos efeitos indutivos do epitélio odontogênico com o ectomesênquima. A enucleação parece ser o tratamento mais indicado, semelhante ao COC clássico. (AU)

Inteligência artificial no processo de diagnóstico: utilização de software para comparação de imagens e perspectivas futuras / Artificial intelligence in the diagnostic process: using software for image comparation and future perspective

Nas últimas décadas a sociedade como um todo foi impactada das mais diversas maneiras pelo uso da tecnologia. Inteligência Artificial é o termo usado para se referir a algoritmos que permitem com que computadores realizem tarefas que exigem a percepção humana para serem feitas. O presente estudo tem o objetivo de relatar o que há de mais recente na literatura sobre o tema de Inteligência Artificial na Odontologia, mais propriamente na área de Patologia Oral e Maxilofacial, e realizar um piloto para diferenciação de lesões utilizando software gratuito. Para realizar o estudo, foram selecionados casos específicos dos últimos 20 anos do Serviço de Patologia Oral e Maxilofacial da Universidade de São Paulo, sendo estes casos de lesões benignas e malignas para comparação e poder elucidar como a patologia através da IA pode ser realizada.). Ao finalizar este processo, o modelo de ML identificou as imagens que foram pedidas para que o software analisasse e uma taxa de acurácia foi obtida, que neste caso foi de 98% de assertividade de que a imagem colocada era referente a uma imagem histológica de uma lesão maligna e de 97% para a lesão benigna (neste caso, um carcinoma epidermoide e um fibroma respectivamente). O estudo concluiu que a IA é pouca explorada tanto no âmbito rotineiro quanto acadêmico e que novas pesquisas devem ser realizadas com incentivo a fim de produzir literatura, mostrar aos estudantes o que pode ser realizado com tecnologia apropriada e agilizar o processo diagnóstico, facilitando a vida do profissional e de todo o sistema que o envolve.

Percepção e práticas de pais/responsáveis sobre questões atuais da odontopediatria: um estudo piloto / Perceptions and practices of parents and guardians on current issues of pediatric dentistry: a pilot study

Objetivo: Investigar as percepções e atitudes de pais/responsáveis sobre cuidados relacionados à saúde bucal das crianças por meio de um estudo descritivo. Métodos: Foi aplicado um questionário semiestruturado aos pais/responsáveis de crianças atendidas nas clinicas de Odontopediatria da Pontifícia Universidade Católica de Minas Gerais (PUC-MG) em 78 pais/responsáveis. O questionário apresentava questões sociodemográficas, assim como questões específicas relacionadas aos cuidados e atitudes para a saúde bucal de seus filhos/crianças. Análise descritiva e exploratória, por meio de médias, frequências e porcentagens foram realizadas e ilustradas por meio de figuras. Resultados: Embora a maioria dos entrevistados tenha alegado já terem recebido informações a respeito dos cuidados bucais infantis, pais/responsáveis consideraram o momento propício para a primeira visita ao dentista somente após o 1º ano de vida, período inadequado para o aleitamento materno, além da utilização inadequada de chupeta e mamadeira por longos períodos e do período para a inserção do hábito da escovação. Além disso, temáticas relacionadas à erosão dentária, teste da linguinha e a importância do íon fluoreto para a saúde bucal foram os assuntos classificados com mais dúvidas. Conclusão: Em geral, as atitudes dos pais e responsáveis não se mostraram adequadas, apesar de possuírem informações prévias no que tange a saúde bucal das crianças. Com isso, verifica-se a necessidade de enfatizar mais a fundo questões referentes a esta temática e diferentes meios para a difusão deste tipo de informação.

Aim: To investigate the perceptions and attitudes of parents/guardians about oral health care for children through a descriptive/cross-sectional study. Methods: A semi-structured questionnaire was applied to 78 parents/guardians of children seen at the Pediatric Dentistry Clinics of the Pontific Catholic University of Minas Gerais (PUC-MG). The questionnaire presented sociodemographic questions, as well as specific questions related to the care and attitudes towards the oral health of their children. Exploratory and descriptive analyses by means of means, frequencies,and percentages were performed and illustrated in figures. Results: Although most of the interviewees claimed to have already received information regarding children's oral care, they considered the proper time for the first visit to the dentist only after the 1st year of life, an inadequate period for breastfeeding, as well as the inappropriate use of pacifiers and bottles for long periods and an improper period for the insertion of the habit of tooth brushing. Furthermore, issues related to dental erosion, the tongue test, and the importance of fluoride ions for oral health were the subjects classified with the most doubts. Conclusion: In general, the attitudes of parents and guardians proved to be inappropriate, although they have previous information regarding the oral health of children. Thus, there is a need to offer a more in-depth emphasis on issues related to this theme and different means through which to disseminate this type of information.

Prevalence of tumours of the maxillomandibular complex diagnosed in a reference center in Brazil

Tumors of the maxillomandibular complex are a heterogeneous group of lesions with a wide spectrum of clinical and histopathological characteristics. Aim: To evaluate the prevalence of odontogenic and non-odontogenic tumors associated with maxillary bones in a Reference Center for Oral Lesions. Methods: A cross-sectional study based on the medical records of a Reference Center for Oral Lesions at the State University of Feira de Santana, from 2006 to 2018. The data was initially analyzed in a descriptive manner. For bivariate analysis, Pearson's chi-square test was applied. The level of significance was set at 5%, where p≤ 0.05 is considered significant. Results: The prevalence of tumors was 2.27%. The average age of the individuals was 22.2 (± 15.1) years, the majority being up to 39 years (79.59%) and female (69.40%). A statistically significant difference was observed in relation to age (p = 0.00), as well as regarding the location of tumors in the anterior or posterior region (p = 0.02). Odontogenic tumors were benign, with odontoma being most frequent (46.90%), followed by ameloblastoma (16.30%). As for the non-odontogenic, neurofibroma (4.10%) and osteoma (4.10%) were the most common across the benign, while osteosarcoma accounted for 6.10% of cases. Conclusion: Odontogenic tumors were the most frequent in women, with age up to 39 years, odontoma being most common in the posterior region of the mandible. Among nonodontogenic tumors, central neurofibroma and osteoma were the most common. Osteosarcoma was more frequent in men over 40 years old and in the mandible region

Evaluation of a telemedicine program in oral pathology and preventive oral examination in Hualqui Municipality, Chile

ABSTRACT: Introduction: A telemedicine program in oral pathology (TOP) and a preventive oral examination (POE) to identify oral lesions was implemented in Hualqui, Chile. The objective of this study is to describe the results of the TOP plus POE strategy at CESFAM Hualqui, Chile, during the period of 2016 to 2019. Materials and methods: A prospective cohort study was conducted with 152 Hualqui patients between 2016 and 2019. The following variables were recorded: diagnosis; injury diagnosis dates; date of teleconsultation; date and response of the specialist and subsequent control; waiting time for response (WTR) and waiting time for attention (WTA). Results: The WTR was 19.7 ± 12.8 days and WTA presented a median of 20 days (1−125) days. A total of 45 different oral pathologies were identified, the most frequent being stomatitis 8.6% (13), fibroma 8.6% (13) and mucocele 7.9% (12), and among the least frequent highlights three cases of oral cancer. Conclusions: The waiting periods until a response from the specialist and then until the face-to-face control were around 3 weeks each, most of the cases were identified through POE and correspond mostly to benign pathologies.

Granuloma piogênico em assoalho bucal: relato de caso / Pyogenic granuloma in mouth floor: case report

O Granuloma Piogênico (GP) é uma lesão de caráter inflamatório originado da membrana mucosa ou do tecido conjuntivo, que possui predileção por pacientes leucodermas, do sexo feminino, entre 11 e 40 anos, especialmente durante a gravidez. Clinicamente apresentase preferencialmente na maxila, com forma irregular, consistente, pediculado, de crescimento lento e sem sintomatologia dolorosa. As principais causas do GP são os traumas ou irritantes locais associados à má higiene oral. Histologicamente apresenta-se bastante vascularizado, organizado em agregados lobulares. O tratamento cirúrgico de escolha é a exérese total da lesão. O objetivo deste trabalho é relatar um caso de granuloma piogênico com características clínicas incomuns, tratado cirurgicamente... (AU)

Piogenic Granuloma (GP) is an inflammatory lesion originating from the mucous membrane or connective tissue, which is predilected by female patients, between 11 and 40 years old, especially during pregnancy. Clinically it presents preferably in the maxilla, with irregular shape, consistent, pediculated, slow-growing and without painful symptomatology. The main causes of GP are the traumas or local irritants associated with poor oral hygiene. Histologically, it is quite vascularized, organized in lobular aggregates. The surgical treatment of choice is the total exeresis of the lesion. The objective of this study is to report a case of pyogenic granuloma with unusual clinical features, treated surgically... (AU)

Clinical and Research Activities of the Brazilian Productivity Fellows in Oral Medicine and Oral Pathology during the COVID-19 Era

ABSTRACT Objective To evaluate the effect of the COVID-19 impacts on the activities of researchers in the field of Oral Medicine (OM) and Oral Pathology (OP). To assess the research activities and training of human resources by Brazilian productivity fellows in research (BPFR) in OM and OP in the COVID-19 Era. Material and Methods Thirty-six BPFR in OM and OP areas, funded by National Council for Scientific and Technological Development (CNPq), received a virtual structured questionnaire by e-mail, on the Google Forms (Google®) platform, with questions regarding research activities and training of human resources (supervision of undergraduate and postgraduate students), during the COVID-19 pandemic. From the thirty-six BPFR in OM and OP, twenty-seven (75.0%) answered the questionnaire. Results Most of them were males (n=20; 74.1%) and were distributed in four Brazilian regions and ten states of the federation, including the Federal District. Twenty-four (88.9%) BPFR reported having suspended clinical activities, while sixteen (59.3%) answered that histopathology practices are suspended. Twenty-five (92.6%) BPFR mentioned difficulties in conducting research projects and 55.5% stated having no difficulties in the supervision of undergraduates, master's and PhD students. Conclusion The current scenario may significantly impact the diagnosis of oral diseases in Brazil. Moreover, a decrease in the scientific production of BPFR in OM and OP in the coming years is also considered.

Agreement Between Clinical-Radiographic and Histopathological Diagnoses in Maxillofacial Fibro-Osseous Lesions

ABSTRACT Objective: To compare the agreement of clinical and radiographic diagnosis with the histopathological diagnosis in fibro-osseous lesions of the jaws. Material and Methods: An analytical and exploratory study was made based on systematic collected data, carried out in the laboratory of surgical pathology of a public Dental School. There were evaluated cases of fibrous dysplasia (FD), cemento-osseous dysplasia (COD) and ossifyng fibroma (OF), diagnosed by clinical, radiographic (panoramic and periapical radiography), and histopathological analysis, in a period of 12 years (from March 2001 to June 2013). Descriptive and inferential statistics (Fisher's exact test) were obtained. Results: Ninety-six cases of FOLs were evaluated. The radiographic aspects of the FOLs studied did not differ significantly (p=0.09). Radiolucent lesions were the least frequent, corresponding to approximately 13.5% of radiographic findings. Mixed lesions and radiopaques were more present, how they were COD and FD, respectively. The more aggressive variation of OF (Juvenile Ossifying Fibroma - JOF) was less frequent among the pathologies evaluated. In approximately 61.46% of the cases clinical and radiographic diagnosis were confirmed by histopathological diagnosis of FOLs. The highest agreement and the highest disagreement were observed in COD cases (40.7% and 62.2%, respectively). Conclusion: FOLs of the maxillaries represent a group of lesions in which the establishment of the clinical and radiographic diagnosis supported by the histopathological confirmation is critical and challenging.

Correlation Between Clinical and Histopathologic Diagnosis of Oral Potentially Malignant Disorder and Oral Squamous Cell Carcinoma

ABSTRACT Objective: To determine the frequency of oral potentially malignant disorders and Oral Squamous Cell Carcinoma (OSCC) and evaluate the consistency between their clinical and pathological features. Material and Methods: This retrospective study was conducted on records with a diagnosis of oral leukoplakia, oral erythroplakia, erythroleukoplakia, actinic cheilitis, lichen planus, and OSCC in the Pathology Department of Kerman dental school from September 1997 to September 2017. Data were analyzed in SPSS 21 at the significance level of ≤5%. Results: There were 378 cases of oral potentially malignant disorders and 70 cases of OSCC with a mean age of 46.82 ± 15.24 years. Buccal mucosa was the most frequent site, and lichen planus the most common lesion. Females were significantly older than males in leukoplakia and carcinoma in situ lesions. Clinical diagnosis and histopathology were consistent in 69.03% of cases. Conclusion: Clinical and histopathological diagnoses were consistent in 69.03% of records. The highest degree of clinical compliance with histopathology was observed in OSCC. Dentists should pay attention to oral potentially malignant disorders for early diagnosis to prevent their transformation to malignancy.

Reliability of Linear and Curvilinear Measurements on Cone-Beam Computed Tomography Images for the Evaluation of Implant Sites and Jaw Pathologies

ABSTRACT Objective: To evaluate the intra-examiner and inter-examiner reliability of linear and curvilinear measurements for the complete assessment of implant sites and jaw pathologies using Cone-Beam Computed Tomography (CBCT). Material and Methods: Fifty cone-beam computed tomographic images of patients were retrieved from the archives of Dentomaxillofacial Radiology. CBCT images taken for implant planning and evaluation of intrabony jaw pathologies (benign cyst/tumor) were included. Two expert oral and maxillofacial radiologists analyzed the images independently and made the measurements. The images for implant planning were analyzed for width, the height of the edentulous site, and the qualitative analysis of bone in the region. Jaw pathologies were assessed for linear dimensions and curvilinear measurements. Results: The inter-observer measurement error for implant site analysis ranged from 0.12 to 0.42 mm with almost perfect agreement (ICC: 0.94 to 1). The inter-observer measurement error for jaw pathology was 0.09 to 0.25 mm (ICC: 0.98-1). Curvilinear measurements showed perfect agreement between the observers. The intraobserver reliability for the various parameters used for the assessment of the implant site and jaw pathologies indicated almost perfect agreement. Conclusion: Reliability between the radiologists is high for various measurements on CBCT images taken for implant planning and jaw pathologies.

Manifestaciones orales en pacientes con Trombocitopenia inmune primaria. Reporte de caso / Oral manifestations in primary immune thrombocytopenia patients. Case report

Resumen Introducción: La trombocitopenia inmune primaria (PTI) es una enfermedad caracterizada por la destrucción acelerada de plaquetas o la producción inadecuada de estas. Se puede clasificar según su etiología en primaria y secundaria. Métodos: Se presenta el caso de un paciente sexo masculino de 30 años de edad, que acude al servicio de urgencia dental del Hospital Barros Luco, por lesiones hemorrágicas mucosa oral y pequeñas manchas rojas en manos, brazos y espalda, de veinticuatro horas de evolución, asintomáticas y sin causa atribuible. Al examen físico se corrobora la presencia de múltiples vesículas hemorrágicas en región bucal y petequias en las zonas descritas. Se realiza diagnóstico presuntivo de PTI que se confirma al obtener un recuento plaquetario (RP) de 2000 uL. Se deriva a medicina interna para evaluación y manejo. La literatura describe que para confirmar esta enfermedad se requiere una historia clínica exhaustiva, descartar una patología sistémica o infecciosa previa y pruebas de laboratorio que evidencien recuento normal de células sanguíneas con una trombocitopenia marcada. Conclusión: El odontólogo tiene un rol significativo en el manejo multidisciplinario en este tipo de cuadros donde el conocimiento de manifestaciones orales de enfermedades sistémicas es de vital importancia para el diagnóstico, derivación y posterior tratamiento de estas.

Abstract Introduction: Primary immune thrombocytopenia (ITP) is a disease characterized by accelerated destruction of platelets or inadequate production of platelets. It can be classified according to its etiology in primary and secondary. Methods: We present the case of a 30-year-old male patient, who comes to the dental emergency service of the Barros Luco Hospital, for oral mucosa hemorrhagic lesions and small red spots on the hands, arms and back, 24 hours of evolution, asymptomatic and without attributable cause. Physical examination corroborates the presence of multiple hemorrhagic vesicles in the oral region and petechiae in the areas described. A presumptive diagnosis of ITP is made and confirmed by obtaining a platelet count (RP) of 2000 uL. He is referred to internal medicine for evaluation and management. The literature describes that confirming this disease requires an exhaustive medical history, ruling out a previous infectious or systemic pathology, and laboratory tests that show normal blood cell counts with marked thrombocytopenia. Conclusions: The dentist has a significant role in multidisciplinary management in this type of condition, where knowledge of oral manifestations of systemic diseases is of vital importance for the diagnosis, referral and subsequent treatment of these. Oral manifestations in primary immune thrombocytopenia patients. Case report

¿Quiste dentigero o ameloblastoma? Importancia del análisis histológico en el diagnóstico de estas patologías / Dentigerous cyst or ameloblastoma? importance of histological analysis in the diagnosis of these pathologies

El quiste dentígero y el ameloblastoma son patologías con poca sintomatología y características clínicas, las cuales son evidentes cuando las lesiones alcanzan dimensiones mayores y esto sucede cuando llevan un tiempo considerable de evolución, por lo cual son descubiertas generalmente en exámenes radiográficos de rutina. El presente artículo describe los hallazgos histológicos y su correlación clínico-patológica y radiográfica entre el quiste dentígero y el ameloblastoma, lo que permite un diagnóstico y un plan de tratamiento. Se presentan dos casos de pacientes masculinos, de 12 y 15 años, que asisten a consulta a la Facultad de Odontología de la Universidad de Cartagena en Colombia, por presentar tumefacción en zona de sínfisis mandibular y en zona de tercer molar inferior derecho. Se especifican hallazgos clínicos, radiográficos e histológicos. Para llegar a los diagnósticos de quiste dentígero y ameloblastoma se deben tener en cuenta todos los hallazgos del examen clínico y radiográfico, pero debe primar el dictamen del examen histopatológico para determinar un tratamiento adecuado. (AU)

Dentigerous cysts and ameloblastomas present with few symptoms, and clinical characteristics present when lesions reach larger dimensions following a considerable length of evolution, and thus, these lesions are often discovered in routine radiographic examinations. This study describes the histological findings and clinical, pathological, and radiographic correlations between dentigerous cysts and ameloblastomas which aid in diagnosis and treatment planning. Two male patients, aged 12 and 15, were attended at the Faculty of Dentistry of the Cartagena University in Colombia due to swelling at the mandibular symphysis and lower right third molar area. The clinical, radiographic and histological findings are described. Clinical and radiographic findings must be taken into account to diagnose dentigerous cysts and ameloblastomas, with histopathological examination providing the definitive diagnosis and allowing adequate patient management. (AU)

Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis - A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso)

ABSTRACT Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The aim of this study was to discuss the risk factors for the development of MRONJ and prevention of this complication in patients with osteoporosis taking antiresorptive drugs and requiring invasive dental treatment. For this goal, a task force with representatives from three professional associations was appointed to review the pertinent literature and discuss systemic and local risk factors, prevention of MRONJ in patients with osteoporosis, and management of established MRONJ. Although scarce evidence links the use of antiresorptive agents in the context of osteoporosis to the development of MRONJ, these agents are considered a risk factor for this complication. Despite the rare reports of MRONJ in patients with osteoporosis, the severity of symptoms and impact of MRONJ in the patients' quality of life make it imperative for health care professionals to consider this complication when planning invasive dental procedures.

Myeloid sarcoma in the tongue

Leukemic cells are rarely present in the oral cavity, and there are very few reports regarding such cases. However, we identified some reports of leukemic cells infiltrating tissues in the oral cavity, including gingival involvement. Recurrent painful oral ulcerations and prominent generalized periodontal destruction are the most common oral features of neutrophil disorders, and they may even be the initial symptoms of the disease. The ulcers may affect any part of the oral mucosa, including the tongue and palate. The objective of this report is to describe and discuss a case of myeloid sarcoma in the oral cavity of a 48-year-old male patient.

Aplicación móvil para la enseñanza de lesiones elementales en cavidad bucal / A mobile application for teaching elementary lesions in the oral cavity

Introducción: El desarrollo de las Tecnologías de la Información y la Comunicación (TIC) y su fácil acceso, hacen de ésta una alternativa educativa que contribuye a incrementar la calidad de la educación, facilitando el proceso de enseñanza-aprendizaje con medios virtuales. Las lesiones elementales son alteraciones del tejido bucal y su conocimiento es importante para realizar un adecuado diagnóstico y manejo terapéutico. Objetivo: Diseñar, implementar y evaluar una aplicación móvil para la enseñanza de lesiones elementales en cavidad bucal. Materiales y métodos: Estudio de intervención, experimental, que evaluó una herramienta educativa sobre lesiones elementales bucales, utilizando una pre-prueba, una intervención y una prueba posterior, para el grupo control se evaluó el aprendizaje a través de la lectura de un artículo. Se compararon los resultados obtenidos mediante prueba de Chi 2 con un p≤0,05. Resultados: Ambos grupos lograron un incremento en el nivel de conocimiento sobre lesiones elementales; sin embargo, quien utilizó la aplicación móvil obtuvo resultados significativamente mejores de aprendizaje (Chi 2 p=0,014). Conclusiones: Las TIC constituyen una estrategia útil para afianzar nuevos conocimientos, se comprobó que los estudiantes que emplearon la herramienta educativa incrementaron significativamente el aprendizaje en lesiones elementales de una forma agradable y amena.

Introduction: The development and widespread access to Information and Communication Technologies (ICTs) have reinforced the view of them as didactic alternatives to improve the quality of education. These technological advances have facilitated the teaching-learning process through the use of virtual media. Knowing elementary lesions in the oral cavity tissue is important for their appropriate diagnosis and therapeutic management. Objective: To design, implement and assess the use of a mobile application in the teaching of elementary lesions of the oral cavity. Materials and methods: An intervention and experimental study that evaluated a didactic tool about oral elementary lesions, applying intervention, pre and post testing. The control group learning skills were assessed through the reading of an article. We finally compared the results via Chi2 test, with p≤0.05. Results: Although both groups showed an improvement in learning levels, the group that used the mobile application achieved significantly better results in reference to learning about elementary lesions (Chi2 p=0.014). Conclusions: ICTs have become useful strategies to strengthen new knowledge. In this study, we show that students who used the educational tool improved the learning of elementary lesions, in a significant and enjoyable way.