Famotidina en el tratamiento de pacientes hospitalizados con COVID-19. Revisión sistemática y metaanálisis / Famotidine in the treatment of hospitalized patients with COVID-19. Systematic review and meta-analysis

Introducción: El síndrome respiratorio agudo severo coronavirus 2 (SARS-CoV-2), de alta morbimortalidad, carece a la fecha de preparar esta revisión, de una terapia específica altamente eficaz. Famotidina se ha postulado como una opción terapéutica viable, basado en trabajos de cohorte retrospectiva y modelos computacionales guiados por inteligencia artificial. Objetivo: Recopilar la mejor evidencia científica disponible para determinar la efectividad y eficacia de famotidina en el tratamiento de pacientes hospitalizados con COVID-19, para reducir el riesgo de progresión de la enfermedad, intubación, muerte y tiempo de estancia hospitalaria. Material y Métodos: Se realizó una búsqueda en PubMed, EBSCO, Scopus, Web of Science y Cochrane Central, de artículos originales que reporten las variables de interés asociadas al uso de famotidina en pacientes hospitalizados con COVID- 19. Los investigadores independientemente evaluaron y seleccionaron los estudios, se extrajeron los datos expuestos para las asociaciones de interés y se procesaron con el software Revman 5.3. Resultados: En la búsqueda se obtuvo un total de 126 artículos potenciales para la revisión, de los cuales 14 fueron seleccionados para el análisis. En el metaanálisis se incluyeron un total de 47.044 pacientes, de los cuales 6.647 fueron los usuarios de famotidina. El riesgo de intubación se vio reducido en el grupo no expuesto a famotidina, aunque sin significancia estadística, (RR 1,43 IC95% 0,42-4,83), en cuanto a la mortalidad no se evidenció reducción significativa en el grupo de famotidina (RR 0,95 IC 95% 0,70-1,29). Se observó reducción en el tiempo de estancia hospitalaria (DM -1,60 -2,89, -0,31) y finalmente se mostró que no hay presencia de asociación entre el uso de famotidina y el desenlace compuesto de reducción del riesgo de ingreso a UCI, intubación y muerte (RR 1,03 IC 95% 0,46-2,34). Conclusión: Famotidina no presenta efectividad ni eficacia en la reducción de riesgo de intubación o ingreso a UCI ni de mortalidad en pacientes hospitalizados por COVID-19. La eficacia en la reducción de la estancia hospitalaria no es consistente y se necesitan más ensayos clínicos con buena calidad metodológica para definirla.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with high morbidity and mortality, lacks, at the time of preparing this review, a highly effective specific therapy. Famotidine has been postulated as a viable therapeutic option, based on retrospective cohort investigations and computational models guided by artificial intelligence. Aim: The objective of this study was to compile the best scientific evidence available to determine the effectiveness and efficacy of famotidine in the treatment of hospitalized patients with COVID-19, to reduce the risk of disease progression, intubation, death, and time to hospital stay. Methods: A search was carried out in PubMed, EBSCO, Scopus, Web of Science, and Central Cochrane, for original articles that report the variables of interest associated with the use of famotidine in hospitalized patients with COVID-19. The investigators independently evaluated and selected the studies, the exposed data for the associations of interest were extracted and processed with Revman 5.3 software. Results: The search yielded a total of 126 potential articles for the review, of which 14 were selected for analysis. A total of 47,044 patients were included in the meta-analysis of which 6,647 were famotidine users. The risk of intubation was reduced in the group not exposed to famotidine, although without statistical significance (RR 1.43 IC95% 0.42 - 4.83), regarding mortality there was no significant reduction in the famotidine group (RR 0.95 IC 95 % 0.70-1.29). A reduction in the length of hospital stay was observed (MD -1.60 -2.89, -0.31) and finally it was shown that there is no association between the use of famotidine and the composite outcome of reduced risk of ICU admission, intubation and death. (RR 1.03 95% CI 0.46-2.34). Conclusion: Famotidine does not show effectiveness or efficacy in reducing the risk of intubation or ICU admission or mortality in patients hospitalized for COVID-19. The efficacy in reducing hospital stay is not consistent and more clinical trials with good methodological quality are needed to define it.

Analysis of the incidence and mortality of thyroid cancer in Shandong Province from 2012 to 2022 based on the age-period-cohort model / 中华预防医学杂志

Objective: To analyze the trend of incidence and mortality of thyroid cancer and estimate its age-period-cohort effect in Shandong Province from 2012 to 2022. Methods: The Joinpoint regression was used to analyze the trend of incidence and mortality of thyroid cancer and calculate the average annual percentage change (AAPC) based on the data on thyroid cancer from 2012 to 2022. The age-period-cohort model was used to analyze the age-effect, time-effect and cohort-effect of thyroid cancer risk in the population aged over 20 years. Results: From 2012 to 2022, the incidence of thyroid cancer in Shandong province showed a significant upward trend, with an AAPC of 21.68% (95%CI: 19.14%-24.27%, P<0.001). The incidence of females was higher than that of males, and the incidence of urban areas was higher than that of rural areas. The trend of thyroid cancer mortality was relatively stable with an AAPC of -3.04% (95%CI:-8.81%-3.09%, P=0.323). The age effect of incidence increased with age before 60 years old and decreased with age after 60 years old. The incidence peaked in the age group of 55-59. The period effect increased with time. The cohort effect showed that the cohort born before 1957 had a downward trend over time, while the cohort born after 1957 had an upward trend. Conclusion: The incidence of thyroid cancer in Shandong shows a rising trend from 2012 to 2022. Age is an important factor affecting the risk of thyroid cancer. The mortality of thyroid cancer remains stable.

Analysis of the incidence and mortality of thyroid cancer in Shandong Province from 2012 to 2022 based on the age-period-cohort model / 中华预防医学杂志

Objective: To analyze the trend of incidence and mortality of thyroid cancer and estimate its age-period-cohort effect in Shandong Province from 2012 to 2022. Methods: The Joinpoint regression was used to analyze the trend of incidence and mortality of thyroid cancer and calculate the average annual percentage change (AAPC) based on the data on thyroid cancer from 2012 to 2022. The age-period-cohort model was used to analyze the age-effect, time-effect and cohort-effect of thyroid cancer risk in the population aged over 20 years. Results: From 2012 to 2022, the incidence of thyroid cancer in Shandong province showed a significant upward trend, with an AAPC of 21.68% (95%CI: 19.14%-24.27%, P<0.001). The incidence of females was higher than that of males, and the incidence of urban areas was higher than that of rural areas. The trend of thyroid cancer mortality was relatively stable with an AAPC of -3.04% (95%CI:-8.81%-3.09%, P=0.323). The age effect of incidence increased with age before 60 years old and decreased with age after 60 years old. The incidence peaked in the age group of 55-59. The period effect increased with time. The cohort effect showed that the cohort born before 1957 had a downward trend over time, while the cohort born after 1957 had an upward trend. Conclusion: The incidence of thyroid cancer in Shandong shows a rising trend from 2012 to 2022. Age is an important factor affecting the risk of thyroid cancer. The mortality of thyroid cancer remains stable.

Dimensões socioculturais da saúde: contribuições para os estudos sobre risco, sociologia digital e desinformação / Sociocultural dimensions of health: contributions to studies on risk, digital sociology, and disinformation / Dimensiones socioculturales de la salud: contribuciones a los estudios sobre riesgo, sociología digital y desinformación

Deborah Lupton é uma renomada acadêmica, cuja trajetória trouxe grandes contribuições para os estudos da sociologia digital e das dimensões socioculturais da medicina e da saúde pública. Em entrevista à Reciis, Lupton comenta sobre um dos principais desafios da contemporaneidade -a desinformação e as fake news- por meio da sociologia digital e aborda as perspectivas socioculturais do risco a partir do lançamento da terceira edição de seu livro Risk, em que traz um capítulo inédito sobre as problemáticas envolvendo o risco e a disseminação de desinformação durante a pandemia de covid-19. Com comentários sobre os cenários australiano e brasileiro, Lupton discorre sobre a questão do anticientificismo, do negacionismo e do papel ocasionado por governos populistas no combate à doença. Por fim, ela discorre sobre as potencialidades dos métodos criativos para os estudos qualitativos, especialmente naqueles que buscam entender as racionalidades, as lógicas e os sentimentos das pessoas

Deborah Lupton is a renowned academic whose research has made significant contributions to the field of digital sociology and the sociocultural dimensions of medicine and public health. In an interview with Reciis, Lupton discusses one of the main contemporary challenges - misinformation and fake news - through the lens of digital sociology and addresses the sociocultural perspectives of risk based on the release of the third edition of her book Risk. In this edition, she includes a new chapter on the issues related to risk and the spread of misinformation during the COVID-19 pandemic. With comments on the Australian and Brazilian scenarios, Lupton delves into the issues of anti-science, denialism, and the role played by populist governments in combating the disease. Finally, she explores the potential of creative methods in qualitative studies, especially those that seek to understand people's rationalities, logics, and feelings

Deborah Lupton es una académica de renombre, cuya trayectoria ha aportado grandes contribuciones a los estudios de sociología digital y a las dimensiones socioculturales de la medicina y la salud pública. En una entrevista con Reciis, Lupton comenta uno de los principales desafíos contemporáneos - la desinformación y las noticias falsas -, a través de la sociología digital, y aborda las perspectivas socioculturales del riesgo a partir del lanzamiento de la tercera edición de su libro Risk, en el que incluye un capítulo inédito sobre los problemas relacionados con el riesgo y la difusión de desinformación durante la pandemia de covid-19. Con comentarios sobre las situaciones en Australia y Brasil, Lupton habla sobre la cuestión del anticientificismo, el negacionismo y el papel desempeñado por los gobiernos populistas en la lucha contra la enfermedad. Finalmente, ella reflexiona sobre las posibilidades de los métodos creativos en los estudios cualitativos, especialmente en aquellos que buscan comprender las racionalidades, lógicas y sentimientos de las personas.

Conocimientos sobre los riesgos de la fiebre y manejo de la misma por madres de niños menores de 5 años que asisten al Centro de Salud CRIN de Vinto, 2023 / Knowledge about the risks of fever and its management by mothers of children under 5 years of age who attend the Health Center CRIN de Vinto, 2023

La fiebre en niños menores de 5 años es considerada a nivel mundial como un signo de alarma ante las múltiples enfermedades, en especial de infecciones respiratorias agudas (IRAS) y enfermedades diarreicas agudas (EDAS). El Foro de las Sociedades Respiratorias Internacionales (2017), afirmó que "las IRAS como primera causa de morbimortalidad con 4 millones de defunciones ocurridos anualmente" y EDAS la segunda causa de muerte con una mortalidad de 525.000 en niños menores de 5 años en cada año y 1700 millones de casos de enfermedades diarreicas infantiles cada año. Según la OMS (2018), "América Latina y el Caribe son de las regiones más diversas del mundo, al mismo tiempo son regiones donde se evidencian mayores disparidades socioeconómicas, es por ello que la OPS indica la necesidad de crear políticas de salud para estas poblaciones. En Bolivia existen 36 diferentes naciones o pueblos indígenas originarios y campesinos, reconocidos por la Constitución Política del Estado" el acceso a la salud de estas poblaciones es limitado y las condiciones en las que viven afecta particularmente la salud de los niños, quienes con frecuencia padecen enfermedades infecciosas que cursan con fiebre, misma que si no es manejada de forma adecuada oportuna puede desencadenar complicaciones que pone en peligro su vida, es por eso que en muchas regiones rurales las madres recurren a diversas prácticas naturales o culturales para el manejo de la fiebre, lo que no siempre es recomendable ya que se debe indagar la causa de la misma y realizar un tratamiento etiológico

COVID-19 en las embarazadas. Riesgo de las complicaciones durante el embarazo y en el neonato / COVID-19 in pregnant women. Risk of complications during pregnancy and in the newborn

Sobre el tema COVID-19 se han publicado múltiples estudios que reflejan su elevada incidencia, transmisibilidad, morbilidad y mortalidad, con gran repercusión y severidad en los grupos poblacionales de riesgo. El embarazo no escapa a ello, y la inmunosupresión fisiológica que se presenta en esta condición, hace a la gestante y al neonato, ser más susceptibles a las enfermedades infecciosas. El objetivo de esta comunicación es profundizar en la fisiopatología y la repercusión de la enfermedad COVID-19 en las gestantes y el neonato, para mejorar el conocimiento relacionado con el tema, el cual repercutirá en un mejor manejo de estos pacientes. Para ello, se realizó una revisión de investigaciones publicadas en el período comprendido entre enero y diciembre de 2021, en las bases de datos: SciELO, SCOPUS, Medline, Dialnet, Cumed y Lilacs. De los 44 artículos obtenidos inicialmente, 33 cumplieron los criterios de inclusión.

Several studies on COVID-19 have been published reflecting its high incidence, transmissibility, morbidity and mortality, with great repercussions and severity in population groups at risk. Pregnancy does not escape from this, and the physiological immunosuppression that occurs in this condition makes the pregnant woman and the newborn more susceptible to infectious diseases. The objective of this communication is to deepen the pathophysiology and the repercussion of the COVID-19 disease in pregnant women and the newborn in order to improve knowledge related to the subject, which will have an impact on better management of these patients. For this, a review of research published between January and December 2021 was carried out in the databases such as SciELO, SCOPUS, Medline, Dialnet, Cumed and Lilacs. A number of 33 articles met the inclusion criteria from 44 initially obtained.

A Exposição de Adolescentes ao Facebook: Uma Revisão Sistemática / The Exposition of Adolescents to Facebook: A Systematic Review / La Exposición de Adolescentes al Facebook: Una Revisión Sistemática

Com a adesão crescente às redes sociais virtuais, a comunicação presencial tem cedido lugar para a comunicação virtual e seu principal local é o Facebook, a rede social mais popular do mundo. O objetivo deste artigo foi analisar a exposição de adolescentes ao Facebooke as implicações dessa exposição para a formação do Self. Foi realizada uma busca nas bases de dados Scientific Eletronic Library Online (SciELO), Periódicos Eletrônicos em Psicologia (PePSIC), Biblioteca Virtual em Saúde Psicologia Brasil (BVS Psi), seguida por duas análises: a primeira, sobre os dados bibliométricos dos 13 artigos selecionados e a segunda, referente a análise feita pelo software iramuteq do corpus textual composto pelos resultados encontrados nos artigos desta revisão. Os resultados foram apresentados em 3 dimensões: 1) formação do Self entre usuários adolescentes no Facebook; 2) exposição ao Facebook e 3) adolescentes no campo do ciberespaço. A conclusão sugere que as possíveis implicações da exposição do adolescente aoFacebook são processos circulados por variáveis de impacto no Self, a partir de elementos como: economia do investimento interpessoal, tempo prolongado no ciberespaço, novas possibilidades de interação e excesso de informações.

As a result of the increase of social networks, face-to-face communication has lost ground in cyberspace, with Facebook being the most popular social network in the world. This article aimed to analyze the exposure of adolescents to Facebook and the implications of the exposure for the formation of the Self. A search was conducted in the Scientific Electronic Library Online (SciELO), Periódicos Eletrônicos em Psicologia (PePSIC), and Biblioteca Virtual em Saúde Psicologia Brasil (BVS Psi), databases, followed by two analyses: the first on the bibliometric data of the 13 selected articles and the second on the analysis by the Iramuteq software of the text corpus formed by the results of the articles of this review. The results were presented in 3 dimensions: 1) Self formation among adolescent Facebook users; 2) Exposure to Facebook and 3) adolescents in the cyberspace field. The conclusion suggests that the possible implications of adolescent exposure to Facebook are processes circulated by variables that impact the Self, such as economy of interpersonal investment, prolonged time in cyberspace, new possibilities of interaction and excess of information.

Con la creciente adhesión a las redes sociales virtuales, la comunicación cara a cara ha dado paso a la comunicación virtual, y su ubicación principal es Facebook, la red social más popular del mundo. El objetivo de este artículo es analizar la exposición de los adolescentes al Facebook y las implicaciones de dicha exposición para la formación del Self. Se realizó una búsqueda en las bases de datos Scientific Electronic Library Online (SciELO), Revistas Electrónicas en Psicología (PePSIC), Biblioteca Virtual en Salud en Psicología Brasil (BVS Psi), seguida de dos análisis: el primero, sobre datos bibliométricos de 13 artículos seleccionados y el segundo se refiere al análisis realizado por el software Iramuteq del corpus textual compuesto por los resultados encontrados en los artículos de esta revisión. Los resultados se presentaron en 3 dimensiones: 1) formación del Self entre los usuarios adolescentes en Facebook; 2) exposición a Facebook y 3) adolescentes en el ámbito del ciberespacio. La conclusión sugiere que las posibles implicaciones de la exposición adolescente en Facebook son procesos que circulan por variables que impactan al Self con base en elementos como: economía de inversión interpersonal, tiempo prolongado en el ciberespacio, nuevas posibilidades de interacción, exceso de información.

Cánula nasal de alto flujo en pacientes críticos: una revisión narrativa / High Flow Nasal Cannula in Critically Ill Patients: a Narrative Review

La cánula nasal de alto flujo se ha convertido en una de las principales estrategias de soporte ventilatorio no invasivo en la insuficiencia respiratoria aguda hipoxémica, principalmente después de la pandemia de COVID-19. Sin embargo, su uso se extiende más allá de este escenario y abarca diferentes condiciones clínicas como el período postextubación, período postquirúrgico, insuficiencia respiratoria hipercápnica y soporte vital en pacientes inmunodeprimidos, trasplantados u oncológicos. Los manuscritos que avalan su aplicación han sido ampliamente difundidos y el grado de evidencia es lo suficientemente alto como para recomendar su uso. Por tanto, es necesario destacar sus efectos fisiológicos como el confort, una fracción inspirada de oxígeno precisa, el lavado de CO2 o la optimización del volumen pulmonar de fin de espiración para comprender su mecanismo de acción y mejorar los resultados de los pacientes. El objetivo de esta revisión narrativa es ofrecer un resumen breve y conciso de los efectos y beneficios de aplicar esta terapia en diferentes escenarios clínicos sin la estructura rígida de una revisión sistemática. Con base en estas líneas, el lector curioso puede ampliar la evidencia científica que avala el empleo de la cánula nasal de alto flujo en cada escenario particular. (AU);

High-flow nasal cannula has become one of the main strategies for non-invasive ventilatory support in hypoxemic acute respiratory failure, mainly after the COVID-19 pandemic. However, its use extends beyond this scenario and covers different clinical conditions such as the post-extubation period, post-surgical period, hypercapnic respiratory failure and life support in immunosuppressed, trasplant or cancer patients. Manuscripts that support its application have been widely disseminated and the degree of evidence is high enough to recommend its use. Therefore, it is necessary to highlight its physiological effects such as comfort, precise fraction of inspiratory oxygen, CO2 lavage or optimize end-expiratory lung volume to understand its mechanism of action and improve patients' outcomes. The objective of this narrative review is to offer a brief and concise summary of the benefits of applying this therapy in different clinical scenarios without the rigid structure of a systematic review. Based on these lines, the curious reader can expand the scientific evidence that supports the use of the high-flow nasal cannula in each particular scenario. (AU);

Uso de plantas medicinais por idosos: Conhecimento dos riscos e benefícios / Medical plants use for elderly: Knowledge of risks and benefits

Objetivo: Avaliar a produção científica acerca da utilização de plantas medicinais por idosos e seus conhecimentos sobre riscos e benefícios. Método: estudo descritivo, exploratório com abordagem qualitativa do tipo revisão integrativa da literatura. Os dados foram coletados em julho de 2015, através das bases de dados eletrônicas Scientific Eletronic Library Online (SCIELO) e Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS). Totalizando 36 artigos que após leitura exaustiva restaram apenas 8 para demonstrar o estudo. Resultados: As principais plantas citadas foram: Matricaria sp.,Lippia Alba, Cymbopogon citratus, Punica , Pimpinella anisum, Menta sp., Plantago sp., Aroeira, Amburana Cearensis, Anacardium occidentale. Observou-se também que esse mesmo grupo vulnerável fez a suspensão do alopático pelo fitoterápico, com riscos de não sucesso terapêutico. Conclusão: é muito importante uma atenção especializada quanto o uso de plantas medicinais por idosos, tendo em vista sua grande vulnerabilidade e os possíveis riscosadvindos desta prática(AU)

Objective:. To evaluate the scientific production about the use of medicinal plants by the elderly and their knowledge about risks and benefits. Method: descriptive, exploratory study with a qualitative approach of the integrative literature review type. Collected in July 2015 through the Scientific Electronic Library Online (SCIELO) and Latin American and Caribbean Literature in Health Sciences (LILACS) electronic databases. Totaling 36 articles that after exhaustive reading, only 8 remained to demonstrate the study. Results: The main plants mentioned were: Matricaria sp., Lippia Alba, Cymbopogon citratus, Punica granatum, Pimpinella anisum, Menta sp., Plantago sp., Aroeira, Amburana Cearensis, Anacardium occidentale. It was also observed that this same vulnerable group discontinued allopathic treatment with herbal medicine, with risks of therapeutic failure. Conclusion: Specialized attention is very important regarding the use of medicinal plants by the elderly, in view of their great vulnerability and the possible risks arising from this practice(AU)

Objetivo: Evaluar la producción científica en la literatura sobre el uso de plantas medicinales por parte de los ancianos y su conocimiento sobre riesgos y beneficios. Método: estudio descriptivo, exploratorio con abordaje cualitativo del tipo revisión integrativa de la literatura. Los datos fueron recolectados en julio de 2015 a través de las bases de datos electrónicas Scientific Electronic Library Online (SCIELO) y Latin American and Caribbean Literature in Health Sciences (LILACS). Totalizando 36 artículos que luego de una lectura exhaustiva, solo quedaron 8 para demostrar el estudio. Resultados: Las principales plantas mencionadas fueron: Matricaria sp., Lippia Alba, Cymbopogon citratus, Punica granatum, Pimpinella anisum, Menta sp., Plantago sp., Aroeira, Amburana Cearensis, Anacardium occidentale. También se observó que este mismo grupo vulnerable suspendió el tratamiento alopático con fitoterapia, con riesgos de fracaso terapéutico. Conclusión: la atención especializada en cuanto al uso de plantas medicinales por parte de los ancianos es muy importante, dada su gran vulnerabilidad y los posibles riesgos derivados de esta práctica.(AU)

Privación de libertad, riesgo suicida y depresión en mujeres de una penitenciaria / Deprivation of freedom and suicide risk in women of a penitentiary

Introducción.El suicidio es un problema clave de salud pública. La situación de privación de libertad es un riesgo aumentado para el suicidio. Hay un aumento de la prevalencia de depresión dentro de las prisiones y su identificación y tratamiento disminuye el riesgo. Objetivo. Determinar el riesgo de suicidio y depresión en mujeres privadas de libertad en una correccional. Metodología.Estudio descriptivo de corte transversal de una muestra por conveniencia de mujeres de una correccional de mujeres en Paraguay. Se utilizó un cuestionario socio-demográfico, la Escala de Suicidio de Plutchik, y el Inventario de Depresión de Beck,previa firma de consentimiento informado que explicó los objetivos del estudio y la participación voluntaria y anónima. Se analizó los datos conel paquete estadístico SPSS versión 15.0. Resultados.Participaron del estudio 108 mujeres entre 20 a 70 años de edad (media: 38 ± 12), 25,9% (n=28) alcanzó escolaridad secundaria completa u universitaria (12%). El 76,8% tenía entre 1 a 5 años de privación de libertad. El 38 % (41) del grupo tenía depresión; 36,1% (n=39) presentó riesgo suicida, 25,9% (n=28) riesgo leve, 7,4% (n=8) riesgo moderado y 2,8% (n=3) riesgo grave. Se encontró asociación altamente significativa entre la presencia de depresión y riesgo suicida (OR: 4,89 IC95% 2,1-11,4). El porcentaje de riesgo suicida fue mayor al de la población general y a cifras arrojadas por otros estudios similares en centros penitenciarios en américa latina. Palabras clave: riesgo; suicida; mujeres; privación; libertad.

Introduction.Suicide is a key public health problem. The situation of deprivation of liberty is an increased risk for suicide. There is an increased prevalence of depression within prisons and its identification and treatment decreases the risk. Objective. To determine the risk of suicide and depression in women deprived of liberty in a correctional facility. Methodology. Descriptive cross-sectional study of a convenience sample of women from a women's correctional facility in Paraguay. A socio-demographic questionnaire, the Plutchik Suicide Scale, and the Beck Depression Inventory were used, after signing an informed consent that explained the objectives of the study and voluntary and anonymous participation. The data was analyzed withthe statistical package SPSS version 15.0. Results.A total of 108 women between 20 and 70 years of age (mean: 38 ± 12) participated in the study, 25.9% (n=28) completed secondary or university education (12%). 76.8% had between 1 and 5 years of deprivation of liberty. 38% (41) of the group had depression; 36.1% (n=39) presented suicidal risk, 25.9% (n=28) mild risk, 7.4% (n=8) moderate risk, and 2.8% (n=3) severe risk. A highly significant association was found between the presence of depression and suicidal risk (OR: 4.89 CI95% 2.1-11.4). The percentage of suicidal risk was higher than that of the general population and figures reported by other similar studies in penitentiary centers in Latin America.Key words:risk; suicide; women; deprivation; liberty.

Percepción de los estudiantes sobre el consumo de drogas psicoactivas en su universidad / Perception of Students Regarding Psychoactive Drug Use at Their University / Percepção de estudantes sobre o consumo de drogas psicoativas na universidade

entre los jóvenes universitarios se ha observado una tolerancia creciente hacia el consumo de drogas, debido ­entre otros factores­ a una reducción en la percepción de riesgo, que puede con-tribuir a la normalización del consumo. El objetivo fue analizar la percepción de los estudiantes de unauniversidad pública mexicana sobre la situación y la gravedad del consumo de drogas en su institución mediante diversos indicadores. Materiales y métodos: se analizó la base de datos derivada de la aplica-ción del Cuestionario sobre Consumo de Drogas en Estudiantes Universitarios (codeu-3), en el que partici-paron 19 815 estudiantes; se realizaron comparaciones según sexo y área académica utilizando pruebas de chi-cuadrado y el análisis post hoc de Bonferroni. Resultados: las mujeres indicaron tener una menor percepción de riesgo que los hombres sobre las variables analizadas (percepción de los participantes sobre el consumo de drogas en su facultad, venta y gravedad del consumo de drogas, según sexo y área académica y conductas de docentes y estudiantes que facilitan el consumo de alcohol y la postura de las autoridades universitarias ante estudiantes consumidores, según sexo y área académica). Conclusión: los resultados muestran diferencias en la percepción de hombres y mujeres, así como las diferencias asociadas con la adscripción de los estudiantes en las distintas áreas académicas, por lo que se sugiere profundizar el estudio de estos aspectos.

There is a growing tolerance toward drug use among university students due to a reduction in the perception of risk, which is considered as those judgments or intuitions held regarding the danger of a situation that can contribute to the normalization of consumption. This study aimed to analyze the perception of the students at a Mexican public university toward the situation and seriousness of drug use in the university using various indicators. Materials and methods: The database derived from the application of the Questionnaire on Drug Use in University Students (codeu-2 by its name in Spanish), in which 19,815 students from a Mexican public university participated, was analyzed, and comparisons were made according to gender and academic area using chi-squared tests and Bonferroni's post hocanalysis. Results: Women were reported to have a lower perception of risk than men on the variables analyzed (participants' perception of drug use in their faculty, sale and severity of drug use, according to gender and academic area, and behaviors of teachers and students that facilitate alcohol use and the position of university authorities towards student consumers, according to gender and academic area). Conclusion: The results indicated the importance of studying in greater depth the differences in the perception of men and women, as well as their affiliation in the different academic areas.

tem-se observado entre os jovens universitários uma crescente tolerância ao uso de dro-gas, devido à redução da percepção de risco, que é considerada como aqueles julgamentos ou intuições que se fazem sobre o perigo de uma situação, o que pode contribuir para a normalização do consumo. O objetivo do estudo foi analisar a percepção dos estudantes de uma universidade pública mexicana sobre a situação e a gravidade do uso de drogas em sua instituição por meio de vários indicadores. Materiais e métodos: analisou-se a base de dados derivada da aplicação do Questionário de Uso de Drogas em Estudantes Universitários (codeu-2), do qual participaram 19,815 estudantes; as comparações foram feitas de acordo com o gênero e a área acadêmica por meio de testes de qui-quadrado e análise post hoc de Bonferroni. Resultados: as mulheres relataram menor percepção de risco do que os homens nas variáveis analisadas (percepção dos participantes sobre o uso de drogas na faculdade, venda e gravidade do uso de drogas, por gênero e área acadêmica, e comportamentos de professores e alunos que facilitam o consumo de álcool e a atitude das autoridades universitárias perante estudantes consumidores, de acordo com o gênero e área acadêmica). Conclusão: os resultados mostram diferenças na percepção de homens e mulheres, bem como as diferenças associadas à inserção dos alunos nas diferentes áreas acadêmicas, para o que se sugere aprofundar o estudo desses aspectos.

Estilos parentais e vinculação aos pares fazem a diferença nos motivos do consumo de álcool em jovens universitários? / ¿Los estilos parentales y el apego a los compañeros marcan la diferencia en los motivos de consumo de alcohol en jóvenes universitarios? / Do Parenting Styles and Peer Attachment Make a Difference in the Reasons for Alcohol Consumption in University Students?

A literatura suporta a importância da relação entre os jovens e as figuras parentais para um desenvolvimen-to adaptativo, nomeadamente capacidades pró-sociais e menor envolvimento em comportamentos de risco. A qualidade das relações com os pares pode também desempenhar um papel protetor no que respeita ao consumo de álcool. O objetivo deste estudo foca-se na análise do efeito dos estilos parentais e da vinculação aos pares nos motivos de consumo de álcool. Participaram 1.044 estudantes universitários de ambos os sexos com idades compreendidas entre os 18 e 25 anos (m= 19.78; dp= 1.68). De forma a recolher os dados recorreu-se a um questionário sociodemográfico, ao Parenting Styles & Dimensions Questionnaire: Short Version (psdq), ao Inventory of Peer and Parental Attachment (ippa-peer), ao Drinking Motives Questionnaire ­ Revised (dmq-r) e ao Alcohol Use Disorders Identification Test (audit). Os resultados apontam para um efeito preditor positivo dos estilos parentais autoritários e permissivos e da alienação aos pares face aos motivos de consumo de álcool e um efeito preditor negativo do estilo parental democrático e de uma vinculação aos pares pautada por comunicação e confiança. As mulheres apresentam maior qualidade relacional com os pares comparativa-mente com os jovens do sexo masculino. Os rapazes apre-sentam uma maior diversidade de motivos de consumo de álcool. Os resultados são discutidos considerando a relevância dos estilos parentais e qualidade das relações com os pares no desenvolvimento pessoal e as motivações dos jovens adultos, em contexto universitário, para a assunção de comportamentos de risco.

La literatura apoya la importancia de la relación entre los jóvenes y las figuras parentales para un desarrollo adaptativo, es decir, habilidades prosociales y menor involucramiento en conductas de riesgo. La calidad de las relaciones con los compañeros también puede desempeñar un papel protector con respecto al consumo de alcohol. El objetivo de este estudio es analizar el efecto de los estilos de crianza y el apego entre pares, sobre las razones para el consumo de alcohol. Participaron 1.044 estudiantes universitarios de ambos sexos con edades comprendidas entre 18 y 25 años (m= 19.78; ds= 1.68). Para la recolección de datos se utilizó un cuestionario sociodemográfico, el Parenting Styles & Dimensions Questionnaire: Short Version (psdq), el Inventory of Peer and Parental Attachment (ippa-peer), el Drinking Motives Questionnaire ­ Revised (dmq-r) y el Alcohol Use Disorders Identification Test (audit). Los resultados indican un efecto predictivo positivo de los estilos parentales autoritarios, permisivos y de alienación de los pares ante los motivos del consumo de alcohol, y un efecto predictivo negativo del estilo paren-tal democrático y de apego a los pares basado en la comunicación y la confianza. Las mujeres tienen más calidad relacional con sus compañeros que los hombres jóvenes. Los hombres tienen una mayor diversidad de motivos para el consumo de alcohol. Los resultados se discuten considerando la relevancia de los estilos de crianza y la calidad de las relaciones con los pares en el desarrollo personal, y las motivaciones de los jóvenes en un contexto universitario para asumir con-ductas de riesgo.

The importance of the relationship between young people and their parental figures for adaptative de-velopment has been supported by literature, namely prosocial capacities and less involvement in risk beha-viors. The quality of peer relationships may also play a protective role regarding alcohol consumption. The aim of this study was to analyze the effect of parenting styles and peer attachment on the reasons for alcohol consumption. Participants were 1.044 university stu-dents of both sexes, between 18 and 25 years of age (m = 19.78; sd = 1.68). For data collection, a socio-demographic questionnaire, the Parenting Styles & Dimensions Questionnaire: Short Version (psdq), the Inventory of Peer and Parental Attachment (ippa-peer), the Drinking Motives Questionnaire ­ Revised (dmq-r), and the Alcohol Use Disorders Identification Test (audit) were used. The results reveal a positive predictive effect of negative parenting styles (authoritarian and permissive) and alienation with peers on the reasons for alcohol consumption and a negative predictive impact on democratic parenting style and peer attachment ba-sed on communication and trust. Women have a better relational quality with their peers compared to males. Men have a greater diversity of reasons for consuming alcohol. Results are discussed considering the relevance of parenting styles, the quality of peer relationships in personal development, and the motivations of young adults, in a university context, for risk-taking behavior.

Percepção de risco e comportamentos de proteção face à covid-19 em estudantes do ensino superior: o papel mediador do medo / Percepción del riesgo y conductas protectoras frente al covid-19 en estudiantes de enseñanza superior: el papel mediador del miedo / Risk Perception and Protective Behaviors Against covid-19 in Higher Education Students: The Mediating Role of Fea

O estudo tem como objetivo descrever os comportamentos de proteção adotados por estudantes portugue-ses do ensino superior durante a pandemia e analisar a sua relação com a percepção de risco e o papel mediador do medo face à covid-19. Participaram 335 estu-dantes com idades entre os 18 e os 29 anos (m= 21.42; dp= 2.43). Os participantes preencheram um inquérito sobre os comportamentos de proteção (i.e., preventi-vos e de evitamento), a percepção de risco e o medo face à covid-19. Os resultados demonstraram que os comportamentos preventivos mais utilizados foram a lavagem/desinfecção das mãos ao longo do dia e o uso de máscara na via pública ou espaços exteriores. Os comportamentos de evitamento mais adotados foram o de evitar locais com aglomeração e os convívios presenciais com colegas/amigos. Verificouse uma as-sociação positiva entre os comportamentos de proteção, a percepção de gravidade e o medo face à covid-19. O medo face à covid-19 foi mediador da relação entre a percepção de gravidade e os comportamentos preventivos (c' = .26, ic 95% [.11; .44]) e de evitamento (c' = .28, ic 95% [.12; .50]). Os resultados são discutidos aten-dendo ao papel da percepção de risco e do medo nas respostas comportamentais dos jovens, num contexto de pandemia, sendo apresentadas implicações práticas e sugestões para estudos futuros.

El estudio tiene como objetivo describir las conductas protectoras adoptadas por los estudiantes portugueses de educación superior durante la pandemia, y analizar su relación con la percepción de riesgo y el papel mediador del miedo al covid-19. Participaron en el estudio 335 estudiantes de entre 18 y 29 años (m = 21.42; ds = 2.43). Los participantes completaron una encuesta sobre conductas protectoras (es decir, preventivas y de evitación), percepción de riesgo y miedo al covid-19. Los resultados mostraron que las conductas preventivas más utilizadas fueron el lavado/desinfección de manos a lo largo del día y el uso de mascarilla en la vía pública o al aire libre. Los comportamientos de evitación más adoptados fueron evadir lugares con reuniones e interacciones cara a cara con compañeros/amigos. Hubo una correlación positiva entre las conductas protectoras, la percepción de seriedad y el miedo al covid-19. También se encontró que el miedo al covid-19 medió la relación entre la percepción de severidad y las conductas preventivas (c' = .26, ic 95% [.11; .44]) y de evitación (c' = .28, ic 95% [.12; .50]). Los resultados se discuten considerando el papel de la percepción del riesgo y el miedo en las respuestas conductuales de los jóvenes en un contexto pandémico, así mismo se presentan impli-caciones prácticas y sugerencias para estudios futuros.

The study aims to describe the protective behaviors adopted by Portuguese higher education students in during the and to analyze their relationship with the perception of risk and the mediating role of fear of covid-19. A total of 335 students aged be-tween 18 and 29 participated in the study (m= 21.42; sd = 2.43). Participants completed a survey on protective (i.e., preventive and avoidance) behaviors, risk perception, and fear of covid-19. The results showed that the most used preventive behaviors were hand washing/disinfection throughout the day and using masks in public streets or outdoor spaces. The most adopted avoidance behaviors were avoiding crowded places and face-to-face interactions with colleagues/friends. There was a positive correlation between pro-tective behaviors, the perception of severity, and fear of covid-19. Fear of covid-19 mediated the relation between the perception of severity and both preventive (c' = .26, ic 95% [.11; .44]) and avoidance (c' = .28, ic95% [.12; .50]) behaviors. The results are discussed considering the role of risk perception and fear in the behavioral responses of young people in a pandemic context while presenting practical implications and suggestions for future studies.

Conhecimento dos estudantes de enfermagem sobre biossegurança no contexto hospitalar na pandemia: abordagem qualitativa / Nursing students' knowledge about biosafety in the hospital context during the pandemic: a qualitative approach

OBJETIVO: Descrever o conhecimento dos estudantes de enfermagem sobre as medidas de biossegurança no contexto hospitalar em tempos de pandemia. MÉTODO: Estudo descritivo, exploratório, qualitativo, com estudantes de enfermagem de uma universidade pública da baixada litorânea do Rio de Janeiro, Brasil, através de entrevista em ambiente virtual, entre julho e setembro de 2021. Utilizou-se o Interface de R pour Analyses Multidimensionnelles de Textes Et de Questionnaires para processamento do corpus textual e Análise de Conteúdo Temática para interpretação das falas. RESULTADOS: Participaram 29 estudantes que reconhecem a biossegurança, mas não possuem segurança ao abordá-la. Para eles, trata-se de normas para proteção do trabalhador e pacientes, associando-as aos EPIs e ao uso durante a pandemia. CONCLUSÃO: A biossegurança não é reconhecida na sua totalidade entre estudantes de enfermagem que estarão no mercado de trabalho futuramente. É necessário um olhar ampliado em perspectiva transversal, especialmente nas disciplinas do ciclo profissionalizante da enfermagem.

OBJECTIVE: To describe Nursing students' knowledge about the biosafety measures in the hospital context in pandemic times. METHOD: A descriptive, exploratory and qualitative study conducted through interviews in a virtual environment between July and September 2021 with Nursing students from a public university in the coastal lowland of Rio de Janeiro, Brazil. Interface de R pour Analyses Multidimensionnelles de Textes Et de Questionnaires was used to process the text corpus and Thematic Content Analysis was employed to interpret the testimonies. RESULTS: The participants were 29 students that recognize biosafety but are not confident enough to address it. For them, it is but a set of standards for the protection of workers and patients alike, associating it with PPE and with its use during the pandemic. CONCLUSION: Biosafety is not recognized in its entirety by the Nursing students who will enter the labor market in the near future. An expanded and cross-sectional perspective is required, especially in the academic disciplines of Nursing training cycle.

Hallazgos histopatológicos pulmonares asociados a COVID-19. Una revisión sistemática y meta-análisis / Histopathological findings in lungs of COVID-19 infected subjects. A systematic review and meta-analysis

El COVID-19 es una nueva enfermedad que requería resultados prontos provenientes de la investigación. Un abordaje para la comprensión de su fisiopatología es conocer el daño a nivel histopatológico que genera en los pulmones de los afectados. Objetivo. Proveer un resumen riguroso de la evidencia disponible sobre los hallazgos histopatológicos pulmonares en pacientes con COVID-19. Se desarrolló una revisión sistemática con metaanálisis de proporciones. Se incluyeron estudios primarios de cualquier diseño que tuvieran datos primarios de hallazgos histopatológicos de pulmones en pacientes COVID-19. Se excluyeron revisiones y guías. Las fuentes de información fueron el repositorio centralizado Living OVerview of Evidence, PubMed/Medline, LitCovid, la base de datos COVID-19 de la Organización Mundial de la Salud, y medRxiv hasta el 3 de abril 2021. La evaluación del riesgo de sesgos se realizó utilizando las herramientas del Instituto Joanna Briggs para series de casos y reportes de casos. Se extrajo cada dato de hallazgo pulmonar histopatológico. Se calcularon las frecuencias encontradas y los datos de los hallazgos más frecuentes fueron resumidas en metaanálisis usando el método de efectos aleatorios de Der Simmonian-Liard. Se midió la heterogeneidad. Los criterios de inclusión fueron cumplidos por 69 artículos sumando 594 sujetos. Presentaron bajo riesgo de sesgos 35 artículos. El metaanálisis de proporciones mostro daño alveolar difuso en 0,62 (IC 95 % 0,51-0,72), I2 59 % (p < 0,01), en su fase temprana (85,14 %). Conclusión. El daño alveolar difuso temprano fue el hallazgo histopatológico más frecuente en muestras pulmonares de pacientes con COVID-19

COVID-19 is a new disease that required prompt results from research. An approach to understanding its pathophysiology is to know the damage at the histopathological level that it generates in the lungs of those affected. Aim. To provide a rigorous summary of the available evidence on pulmonary histopathological findings in patients with COVID-19. A systematic review with meta-analysis of proportions was developed. Primary studies of any design that had primary data on lung histopathology findings in COVID-19 patients were included. Reviews and guidelines were excluded. The sources of information were the Living OVerview of Evidence centralized repository, PubMed/Medline, LitCovid, the World Health Organization COVID-19 database, and medRxiv up to April 3, 2021. The risk of bias assessment was performed using the Joanna Briggs Institute tools for case series and case reports. Each histopathological pulmonary finding data was extracted. The frequencies found were calculated and the data of the most frequent findings were summarized in meta-analyses using the Der Simmonian-Liard random effects method. Heterogeneity was measured. The inclusion criteria were met by 69 articles totaling 594 subjects. Thirty-five articles presented low risk of bias. The meta-analysis of proportions showed diffuse alveolar damage in 0.62 (95% CI 0.51-0.72), I2 59% (p < 0.01), in its early phase (85.14%). Conclution. Early diffuse alveolar damage was the most frequent histopathological finding in lung samples from patients with COVID-19

An Investigation of the Effects of B7-H4 Gene rs10754339 and miR-125a Gene rs12976445 on Cancer Susceptibility / 生物医学与环境科学（英文）

OBJECTIVE@#To investigate the effects of the B7-H4 gene rs10754339 and miR-125a gene rs12976445 on cancer susceptibility through a case-control study and meta-analysis.@*METHODS@#A total of 1,490 cancer patients (lung/gastric/liver/: 550/460/480) and 800 controls were recruited in this case-control study. The meta-analysis was performed by pooling the data from previous related studies and the present study.@*RESULTS@#The results of this study showed that in the Hubei Han Chinese population, the rs10754339 gene was significantly associated with the risk of lung and gastric cancer but not liver cancer, and the rs12976445 gene was significantly associated with the risk of lung cancer but not liver or gastric cancer. The meta-analysis results indicated that rs10754339 and rs12976445 contributed to cancer susceptibility in the Chinese population and also revealed a significant association between rs10754339 and breast cancer risk, as well as between rs12976445 and lung cancer risk.@*CONCLUSION@#The B7-H4 gene rs10754339 and miR-125a gene rs12976445 may be the potential genetic markers for cancer susceptibility in the Chinese population, which should be validated in future studies with larger sample sizes in other ethnic populations.

Lung Cancer Risk Attributable to Active Smoking in China: A Systematic Review and Meta-Analysis / 生物医学与环境科学（英文）

OBJECTIVE@#No consensus exists on the relative risk ( RR) of lung cancer (LC) attributable to active smoking in China. This study aimed to evaluate the unified RR of LC attributable to active smoking among the Chinese population.@*METHODS@#A systematic literature search of seven databases was conducted to identify studies reporting active smoking among smokers versus nonsmokers in China. Primary articles on LC providing risk estimates with their 95% confidence intervals ( CIs) for "ever" "former" or "current" smokers from China were selected. Meta-analysis was used to estimate the pooled RR of active smoking.@*RESULTS@#Forty-four unique studies were included. Compared with that of nonsmokers, the pooled RR (95% CI) for "ever" "former" and "current" smokers were 3.26 (2.79-3.82), 2.95 (1.71-5.08), and 5.16 (2.58-10.34) among men, 3.18 (2.78-3.63), 2.70 (2.08-3.51), and 4.27 (3.61-5.06) among women, and 2.71 (2.12-3.46), 2.66 (2.45-2.88), and 4.21 (3.25-5.45) in both sexes combined, respectively.@*CONCLUSION@#The RR of LC has remained relatively stable (range, 2-6) over the past four decades in China. Early quitting of smoking could reduce the RR to some extent; however, completely refraining from smoking is the best way to avoid its adverse effects.

Comparative HPV genotype distribution among women with normal and abnormal cervical cytology in Yaoundé, Cameroon

Background: The epidemiology of human papillomavirus (HPV) infection and the pattern of HPV genotype distribution are parameters needed to assess the risk of cervical cancer. Oncogenic HPV types are well-known pathogen for lower genital tract neoplasias, representing the primary cause of cancer death in Africa and the second in Cameroon. This study was conducted to identify the various genotypes particularly the high-risk HPV types in normal and abnormal cervical cytology from women in Yaoundé, Cameroon. Methodology: This was a hospital-based, analytical cross-sectional study carried out on 226 symptomatic women wherein cervico-vaginal samples were obtained during gynaecological examination for Pap smears, HPV-DNA and genotype detection with linear array HPV strip, conducted from November 2019 to January 2021. Results: From the 226 women whose cervical samples were collected for Pap smears, 71 (31.4%) had abnormal cytology results while 155 (68.6%) had normal results. The overall HPV prevalence in the study population was 34.1% (77/226). The HPV prevalence in women with abnormal Pap smears was 100% (71/71) and are distributed in following descending order; LSIL (21.1%, 15/71), HSIL (21.1%, 15/71), ASC-US (19.7%, 14/71), ICC (19.7%, 14/71) and others (18.4%, 13/71). HPV-DNA was positive in 6 (3.9%) of the 155 women with normal cytology results, 4 (2.6%) of whom were high-risk HPV. There is statistically significant difference in the HPV prevalence between women with abnormal and normal Pap smear results (OR=3289, 95% CI=182.62-59235, p<0.0001). The frequently identified oncogenic HPV types were type 16 (31.2%, 24/77), type 45 (14.3%, 11/77) and type 18 (10.4%, 8/77). Conclusion: It is evident from our study that symptomatic women with normal Pap smear can have HR-HPV infection and should therefore be screened for HPV and followed up with periodic Pap smears to detect any abnormal change in cervical cytology results, to prevent cervical cancer development. Women should be encouraged to take up cervical screening, through Pap smears, because it is a non-invasive and cost-effective method for early detection of preinvasive lesions