Physicochemical, proximate and sensory evaluation of pearl millet and pigeon pea based nutrient dense mix

Severe acute malnutrition serves a high risk of mortality among children aged 6-59 months. At a community level anganwadi centers play a vital role in identifying malnutrition among children and enabling resources for growth and development. The aim of this study was to develop a nutrient dense mix using pearl millet and pigeon pea and evaluate its sensory, physicochemical and proximate properties. The nutrient dense mix was formulated using pearl millet and pigeon pea in several variations and the best accepted variation was selected through sensory evaluation and analyzed for its physiochemical and proximate composition. Variation 3 of the nutrient dense mix prepared by balancing pearl millet with rice had the highest acceptability in all sensory parameters. It had favorable physicochemical properties including water solubility index (20.1%), swelling power (3.7%) and low moisture content (3.7%). The proximate analysis revealed high energy (347.10±0.85 kcals), protein (14.28±0.04 g), fat (19.53±0.03) and calcium content (154.63±2.2 mg). The percentage adequacy of the nutrients from the nutrient dense mix showed that 31.27% of energy as per the estimated average requirements was met for 1-3 year olds and 25.5% for 4-6 year olds. The high sensory acceptability, low cost and good micro and macronutrient profile encourages further exploration for the product in curbing malnutrition.

Assessment of lead augmented vector left (aVL on surface electrocardiogram) for confirming atrioventricular nodal reentrant tachycardia

Background: Atrioventricular nodal reentrant tachycardia (AVNRT) stands as one of the most common forms of paroxysmal supraventricular tachycardia (PSVT), encompassing a wide spectrum of clinical presentations and diagnostic challenges. The aim of this study was to evaluate the assessment of lead aVL (surface ECG) for confirming AVNRT. Methods: This was a prospective observational study and was conducted at the Department of Cardiology and Electrophysiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh during the period from February 2019 to January 2020. Results: In our study 41 patients (66.1%) had AVNRT and 21 patients (33.9%) had AVRT on the final evaluation. Total 33.9% of patients had aVL notch on ECG. Among patients who had AVNRT, 46.3% had an aVL notch and among patients who had AVRT, 9.5% had an aVL notch on ECG. The difference was statistically significant (p=0.004). Among 21 patients who had aVL notch on ECG, 6 (31.6%) male patients had AVNRT, 13 (64.8%) female patients had AVNRT, 1 (50%) male patients had AVRT and 1 (50%) female patient had AVRT. Conclusions: In conclusion, the interpretation of electrocardiographic criteria, including the aVL notch, plays a pivotal role in confirming the diagnosis of AVNRT and guiding therapeutic interventions.

Hepatitis B virus total core antibody status in unvaccinated general population in a community of Bangladesh

Background: Hepatitis B virus (HBV) infection poses a significant health challenge in Bangladesh, with the hepatitis B core antibody (anti-HBc) being a crucial marker due to its lifelong presence in the bloodstream. This study aimed to evaluate the prevalence of anti-HBc (total) positivity among unvaccinated adults in Northeastern Bangladesh. Methods: This cross-sectional observational study was conducted in the Sobhanighat area of Sylhet, Bangladesh, in collaboration with the department of gastroenterology, Sylhet MAG Osmani Medical College, from November 2022 to August 2023. A total of 216 participants were selected using consecutive sampling. HBsAg, anti-HBs, and anti-HBc (total) were tested for all subjects, and data were collected using a pre-formed questionnaire and analyzed using statistical package for the social sciences (SPSS) version 24. Results: Among the participants, 16 (7.4%) tested positive for anti-HBc (total), while HBsAg was positive in 6 (2.77%) individuals. Anti-HBs was detectable in 23 (10.6%) participants, with 3 (1.38%) showing isolated anti-HBc positivity. Notably, 20% of HBsAg-positive cases exhibited heterotypic anti-HBs. Moreover, 56.25% of respondents with anti-HBc (total) positivity had detectable anti-HBs (p<0.001). Gender did not show significant associations with HBsAg, anti-HBc (total), anti-HBs, or isolated anti-HBc (p>0.05). Conclusions: The study underscores a notable prevalence of anti-HBc (total) positivity among unvaccinated individuals in Bangladesh, indicative of past HBV exposure. It underscores the necessity for enhanced vaccination coverage and robust infection control measures to mitigate HBV transmission in this demographic.

An ambispective observational study on antibiotics in pulmonology department in a tertiary care hospital

Background: Respiratory tract infections (RTIs) caused by various viruses and bacteria are a major cause of morbidity and mortality worldwide. Although they are usually more severe in children, the elderly and people with weakened immune systems, people of all ages and backgrounds are susceptible to these infections. Antibiotics are commonly prescribed for RTIs in primary care in adults and children. The main purpose of this study is to monitor the use of different antibiotics for respiratory infections. Methods: It is an ambispective observational study, during which data are collected on specially designed data collection forms. The study lasted 6 months (from December 2022 to May 2023). Results: The source of data is a total of 100 patients who were prescribed at least one dose of antibiotics. Out of 100 people, 53% were men and 47% were women. LRTI and URTI are the most common conditions for which antibiotics are prescribed, and we found that the most commonly prescribed antibiotics are a higher percentage of patients using cephalosporins. Of the various cephalosporins, the most commonly prescribed is ceftriaxone, a third-generation cephalosporin. Conclusions: From this particular observational study, we concluded that the most frequently prescribed antibiotics for respiratory infections were cephalosporins, ceftriaxone, third-generation cephalosporins were most frequently prescribed, followed by macrolides, penicillin, tetracyclines, lincomycin, fluoroquinolones, oxazolidinones. The use of antibiotics helps to improve patient care by reducing side effects such as antibiotic resistance, hypersensitivity reactions, respiratory difficulties and risks associated with respiratory infections.

Fear and depression among health care professionals: a cross-sectional study during COVID-19 pandemic in Bangladesh

Background: COVID-19 pandemic is a public health emergency of international concern that can result in severe mental health conditions like depression and fear in health-care professionals (HCPs). Methods: A cross-sectional study was conducted, where 834 HCPs were self-recruited via social media. Multiple linear regression analyses were performed to identify predicting factors. Results: Approximately one-third of the total participants were depressed (27.3%) and those with depressive symptoms had significant fear of COVID-19. Significant risk factors for depressive symptoms were being female, being married, having no children, having high risk elderly persons at home, being afraid of death due to COVID-19 and having comorbid diseases. Fear of death due to COVID-19 was the most common significant contributing factor the scales for depression model, ?=0.397, for fear of COVID-19 model and ?=0.478 respectively. Quality of PPE played a vital role for depression as majority of HCPs. About 65.3% of HCPs who were restless while examining a patient with flu symptoms and majority of HCPs who felt insecure about their family members. Conclusions: Most of the HCPs faced several challenges during COVID-19 and psychological impacts of frontline HCPs were associated with interventions and rehabilitations to improve the mental health.

Effects of Se nanoparticles supplementation on growth performance, hematological parameters and nutrient digestibility of Labeo rohita fingerling fed sunflower meal based diet / Efeitos da suplementação de nanopartículas de Se no desempenho de crescimento, parâmetros hematológicos e digestibilidade de nutrientes da dieta baseada em farinha de girassol alimentada com alevinos de Labeo rohita

Abstract The aim of the present study is to assess the effects of selenium nanoparticles on the growth, hematology and nutrients digestibility of Labeorohita fingerlings. Fingerlings were fed with seven isocaloric sunflower meal-based diet supplemented with different concentrations of nanoparticles naming T1 to T7 (0, 0.5, 1, 1.5, 2, 2.5, and 3 mg/kg), with 5% wet body weight while chromic oxide was used as an indigestible marker. After experimentation for 90 days T3 treated group (1mg/kg -1Se-nano level) showed the best result in hematological parameters (WBC's 7.97 ×103mm-3, RBC's 2.98 ×106 mm-3 and Platelet count 67), nutrient digestibility (crude protein: 74%, ether extract: 76%, gross energy: 70%) and growth performance (weight gain 13.24 g, weight gain% 198, feed conversion ratio 1.5, survival rate 100%) as compared to the other treatment groups. Specific growth rates were found significantly higher in T5 than in other groups. The present study indicated positive effect of 1 mg/kg Se-nanoparticles on growth advancement, hematological parameters, and nutrients digestibility of L. rohita fingerlings.

Resumo O objetivo do presente estudo é avaliar os efeitos das nanopartículas de selênio no crescimento, hematologia e digestibilidade dos nutrientes de alevinos de Labeo rohita. Os alevinos foram alimentados com sete dietas isocalóricas à base de farinha de girassol suplementada com diferentes concentrações de nanopartículas, nomeando T1 a T7 (0, 0,5, 1, 1,5, 2, 2,5 e 3 mg / kg), com 5% do peso corporal úmido enquanto o óxido crômico foi usado como um marcador indigesto. Após a experimentação por 90 dias, o grupo tratado com T3 (nível 1mg / kg -1Se-nano) mostrou o melhor resultado em parâmetros hematológicos (WBC's 7,97 × 103mm-3, RBC's 2,98 × 106mm-3 e contagem de plaquetas 67), digestibilidade dos nutrientes (proteína bruta: 74%, extrato de éter: 76%, energia bruta: 70%) e desempenho de crescimento (ganho de peso 13,24 g, ganho de peso % 198, taxa de conversão alimentar 1,5, taxa de sobrevivência 100%) em comparação com os outros grupos de tratamento. As taxas de crescimento específicas foram encontradas significativamente mais altas em T5 do que em outros grupos. O presente estudo indicou efeito positivo de 1 mg / kg de nanopartículas de Se no avanço do crescimento, parâmetros hematológicos e digestibilidade de nutrientes de alevinos de L. rohita.

Effects of Se nanoparticles supplementation on growth performance, hematological parameters and nutrient digestibility of Labeo rohita fingerling fed sunflower meal based diet

Abstract The aim of the present study is to assess the effects of selenium nanoparticles on the growth, hematology and nutrients digestibility of Labeorohita fingerlings. Fingerlings were fed with seven isocaloric sunflower meal-based diet supplemented with different concentrations of nanoparticles naming T1 to T7 (0, 0.5, 1, 1.5, 2, 2.5, and 3 mg/kg), with 5% wet body weight while chromic oxide was used as an indigestible marker. After experimentation for 90 days T3 treated group (1mg/kg -1Se-nano level) showed the best result in hematological parameters (WBCs 7.97 ×103mm-3, RBCs 2.98 ×106 mm-3 and Platelet count 67), nutrient digestibility (crude protein: 74%, ether extract: 76%, gross energy: 70%) and growth performance (weight gain 13.24 g, weight gain% 198, feed conversion ratio 1.5, survival rate 100%) as compared to the other treatment groups. Specific growth rates were found significantly higher in T5 than in other groups. The present study indicated positive effect of 1 mg/kg Se-nanoparticles on growth advancement, hematological parameters, and nutrients digestibility of L. rohita fingerlings.

Resumo O objetivo do presente estudo é avaliar os efeitos das nanopartículas de selênio no crescimento, hematologia e digestibilidade dos nutrientes de alevinos de Labeo rohita. Os alevinos foram alimentados com sete dietas isocalóricas à base de farinha de girassol suplementada com diferentes concentrações de nanopartículas, nomeando T1 a T7 (0, 0,5, 1, 1,5, 2, 2,5 e 3 mg / kg), com 5% do peso corporal úmido enquanto o óxido crômico foi usado como um marcador indigesto. Após a experimentação por 90 dias, o grupo tratado com T3 (nível 1mg / kg -1Se-nano) mostrou o melhor resultado em parâmetros hematológicos (WBCs 7,97 × 103mm-3, RBCs 2,98 × 106mm-3 e contagem de plaquetas 67), digestibilidade dos nutrientes (proteína bruta: 74%, extrato de éter: 76%, energia bruta: 70%) e desempenho de crescimento (ganho de peso 13,24 g, ganho de peso % 198, taxa de conversão alimentar 1,5, taxa de sobrevivência 100%) em comparação com os outros grupos de tratamento. As taxas de crescimento específicas foram encontradas significativamente mais altas em T5 do que em outros grupos. O presente estudo indicou efeito positivo de 1 mg / kg de nanopartículas de Se no avanço do crescimento, parâmetros hematológicos e digestibilidade de nutrientes de alevinos de L. rohita.

Prediction of promiscuous multiepitope-based peptide vaccine against RdRp of rotavirus using immunoinformatics studies

ABSTRACT Rotavirus, a dsRNA virus in the Reoviridae family, shows a segmented genome. The VP1 gene encodes the RNA-dependent RNA polymerase (RdRp). This study aims to develop a multiepitope-based vaccine targeting RdRp using immunoinformatic approaches. In this study, 100 available nucleotide sequences of VP1-Rotavirus belonging to different strains across the world were retrieved from NCBI database. The selected sequences were aligned, and a global consensus sequence was developed by using CLC work bench. The study involved immunoinformatic approaches and molecular docking studies to reveal the promiscuous epitopes that can be eventually used as active vaccine candidates for Rotavirus. In total, 27 highly immunogenic, antigenic, and non-allergenic T-cell and B-cell epitopes were predicted for the Multiepitope vaccine (MEV) against rotavirus. It was also observed that MEV can prove to be effective worldwide due to its high population coverage, demonstrating the consistency of this vaccine. Moreover, there is a high docking interaction and immunological response with a binding score of −50.2 kcal/mol, suggesting the vaccine's efficacy. Toll-like receptors (TLRs) also suggest that the vaccine is physiologically and immunologically effective. Collectively, our data point to an effective MEV against rotavirus that can effectively reduce viral infections and improve the health status worldwide.

Surgical and functional outcome of laparoscopic vaginal suspension combined with suture rectopexy for management of pelvic organ prolapse

Purpose: Laparoscopic techniques to treat pelvic organ prolapse are gaining popularity around the globe due to their low recurrence rates and better functional results compared to perineal techniques. However, the optimum surgical procedures are not yet determined. In the current research, we suggest a novel surgical approach, laparoscopic vaginal suspension with suture rectopexy, to treat multiorgan pelvic prolapse. Methods: This prospective cohort trial was conducted from March 2018 to March 2022 and comprised 35 females with multiorgan pelvic organ prolapse with obstructed defecation symptoms. A residual rectal prolapse was still present despite the manual reduction of uterine prolapse. Patients' conditions before and after the operation were monitored regarding the obstructed defecation score, sexual function, need for laxatives, anorectal manometry pressures, anorectal sensations, and recurrence. The mean follow-up duration was one year. Results: Modified Longo score for obstructed defecation significantly decreased at six and twelve months after surgery. Additionally, a significant reduction was reported in the number of patients who needed laxatives at six and twelve months after surgery. Anorectal manometry pre- and post-surgery showed a significant elevation in the mean squeeze pressure and a decline in all rectal sensations. All parameters of the female sexual function scoring system increased postoperatively. No recurrence was reported during follow-up. Conclusion: For multiorgan pelvic prolapse, laparoscopic vaginal suspension combined with suture rectopexy has excellent functional outcomes, minimal morbidity, and low cost. (AU)

Marginal Zone B-cell Lymphoma of the Gasserian Ganglion: Case Report and Review of the Literature / Linfoma de células B da zona marginal do gânglio de Gasser: Relato de caso e revisão da literatura

Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal non-Hodgkin's lymphoma that accounts for 4% of newly diagnosed central nervous system (CNS) tumors. Most primary lymphomas of the central nervous system are of the subtype of diffuse large B-cell lymphomas, which have highly aggressive behavior and may involve the brain, leptomeninges, eyes or spinal cord without evidence of systemic disease. Primary CNS lymphomas are very rare in immunocompetent patients, but their rates are increasing. So far, only 11 primary Gasser ganglion lymphomas have been reported, with an incidence of 2.5 cases per 30,000,000 inhabitants. However, B cell lymphomas of the marginal zone of the Gasserian ganglion have been very rarely reported. We report here a clinical presentation characteristic of B cell lymphoma of the marginal zone of the Gasser ganglion in an immunocompetent patient who was treated with surgery and radiotherapy, evolving with improvement of symptoms and without recurrence in 3 months of follow-up.

O linfoma primário do sistema nervoso central (PCNSL, na sigla em inglês) é um subtipo raro de linfoma não-Hodgkin extranodal que representa 4% dos tumores recém-diagnosticados do sistema nervoso central (SNC). A maioria dos linfomas primários do sistema nervoso central é do subtipo dos linfomas difusos de grandes células B, que tem comportamento altamente agressivo e pode envolver cérebro, as leptomeninges, os olhos ou a medula espinhal sem evidências de doença sistêmica. Os linfomas primários do SNC são muito raros em pacientes imunocompetentes, mas suas taxas estão aumentando. Até o momento, apenas 11 linfomas primários do gânglio de Gasser foram relatados, com uma incidência de 2,5 casos por 30.000.000 de habitantes. No entanto, linfomas de células B da zona marginal do gânglio de Gasserian foram muito raramente relatados. Relatamos aqui uma apresentação clínica característica de um linfoma de células B da zona marginal do gânglio de Gasser em um paciente imunocompetente que foi tratado com cirurgia e radioterapia, evoluindo com melhora dos sintomas e sem recorrência em três meses de acompanhamento.

Clinical outcomes of the liver-first approach in the management of synchronous colorectal liver metastases: a retrospective study

Introduction: Almost 25% of colorectal cancer (CRC) patients have synchronous colorectal liver metastasis (SCLM) coinciding with the disease diagnosis. Liver-first approach for the treatment of SCLM involves neoadjuvant chemotherapy, subsequent liver resection, and then primary tumor resection. This strategy is adopted as the prognosis of the disease depends mainly on the metastases, not the primary tumor. This study aims to evaluate the feasibility of the liver-first approach and clinical prognosis in managing SCLM. Materials and Methods: This retrospective study included 25 patients with SCLM from July 2015 to July 2020. All patients were subjected to a liver-first approach with an "intention-to-treat" approach. Follow-up was planned for at least 3 years. Data were collected from the hospital records and included survival rates and univariate analyses of the prognostic factors, such as gender, age, and number of chemotherapy cycles to evaluate their effect on the survival probability. Results: Nineteen patients completed the treatment paradigm. Long-term outcomes reported a median overall survival (OS) of 32 months. One-year and 3-year survival probabilities were 89.5% and 42.1%, respectively. The median disease-free survival was 13 months. The number of metastatic lesions, unilobar versus bilobar disease, and the frequency of administered chemotherapy cycles significantly affected survival (p < 0.05). Seven patients (36.84%) remained disease free (no recurrence) while 2 patients (10.53%) survived with recurrence. The overall mortality included 10 deaths (52.63%) due to recurrence. Conclusion: Synchronous colorectal liver metastasis treated with the liver-first approach achieved a notable overall advantage. However, the recurrence rate remained relatively high. (AU)

Status of vitamin D and disease pattern among sedentary adults 18-60 years attending a selected institution in Dhaka city

Background: Vitamin D deficiency is a global health concern affecting individuals across all the age groups in both the genders. It is an essential element that is essential for the production, regulation and absorption of calcium and phosphorus by the human body, as well as for the proper maintenance of teeth and bones and to make your immune system work. Vitamin D is not actually a vitamin; it falls under the pro-hormone category. Because the human body is perfectly capable of producing vitamin D on its own when exposed to sunlight, and vitamins are the type of nutrients that the body cannot or cannot produce automatically, that we consume through dietary supplements. Methods: It was a cross sectional study the sample size was 369. Vitamin D level of all the participants was estimated by using an ADVIA Centaur XPT stem designed to perform continuous operations immunoassay methods. The data were processed to undergo statistical analysis using SPSS 23 windows program. Microsoft Word, Microsoft Excel were used to represent the tabular, charts and graphical icon. Results: The prevalence of vitamin D deficiency exhibited a medical condition increment in both the males and females. This study had clear association was observed using bivariate analysis for any of the three chronic conditions such as hypertension, cardiovascular disease and osteomalacia where (p=0.021), (p=0.039) and (p=0.000) explored in the current study with severe deficiency status. Conclusions: Vitamin D deficiency was prevalent even in apparently healthy young individuals; this study is suggestive of a higher prevalence of vitamin D deficiency among young adults, females, Bangladeshi nationality and those with higher BMI.

MTHFR C677T Polymorphism, Plasma Homocysteine, and PDGF-AA Levels and Transcranial Doppler Velocity in Children With Sickle Cell Disease

Objective: To evaluate the effect of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on plasma homocysteine (tHcy) and platelet-derived growth factor (PDGF-AA) levels in children with sickle cell disease (SCD), and ascertain their role in predicting high transcranial doppler velocity (TCD). Methods: We estimated MTHFRC677T gene polymorphism, plasma tHyc and PDGF-AA in 44 SCD patients and 44 healthy children. Results: The prevalence of mutant homozygous MTHFR (C677TT) in SCD was 13.6%. Significantly higher plasma tHcy was observed in mutant homozygous MTHFRC677TT patients. Significantly higher plasma tHcy and PDGF-AA levels were observed in SCD patients than in controls. Median (IQR) PDGF-AA levels were significantly higher in conditional and high-risk TCD patients as compared to low-riskTCD patients [325 (93.1-368) and 368 (111-480) vs 111 (56-201) pg/mL, respectively; P<0.001]. Mean (SD) tHcy levels were significantly higher in high-risk TCD children than low-risk TCD children (12.9 (2.7) vs 9.9 (2.5) µmol/L; P=0.006). The receiver operating characteristic revealed that the area under the curve (AUC) of PDGF-AA for high TCD velocity was 0.934 (95% CI 0.845-1.00; P<0.001) and tHcy had an AUC of 0.675 (95% CI 0.517-0.833; P=0.04). Conclusion: PDGF-AA and tHcy levels could be used as predictive markers for stroke in SCD children. MTHFR Polymorphism contributes to elevated tHcy levels.

Prevalence of musculoskeletal disorders in elderly population in a rural community of Bangladesh

Background: Musculoskeletal disorders are a leading source of physical impairment in elderly, and the frequency of these disorders is anticipated to increase rapidly as the population ages. In Bangladesh, musculoskeletal disorders among the elderly are on the rise, causing them immense misery. The aim of this study to find out prevalence of musculoskeletal disorder in this age group in a rural community of Bangladesh. Methods: A descriptive cross-sectional study was conducted over the period of one year from April 2017 to March 2018 in a few villages of Mokshedpur union of Dohar Upazila in Dhaka district of individuals with 60 and above. Modified COPCORD (Community Oriented Program for Control of Rheumatic Disorders) questionnaire was used to detect positive respondents. Results: The prevalence of musculoskeletal pain was 52.10%. Prevalence was higher in women, 113 (56.6%) than men, 85 (43.4%). Most of the patient belongs to age group 60-69 (79.3%). Higher prevalence rates were observed in housewife (42%), retired person (24%) and cultivators (17%). Most of the individual had no smoking habit, 145 (73.2) and 42.9% are daily smokeless tobacco users. Lower back pain (42.4%) and knee pain (37.4%) were prevalent among the study group. Non-specific low back pain (28.8%) and osteoarthritis in the knee (26.3%) were prevalent among the study group. Among all the disorder, female is prevalent than male. Conclusions: Musculoskeletal disorders are common causes of morbidity and disability in rural communities of Bangladesh. Women are affected more frequently than men. Mechanical disorders are more common than inflammatory arthropathies.

Ovarian reserve in adolescent girls with autoimmune thyroiditis

ABSTRACT Objectives: To assess serum anti-Müllerian hormone (AMH) levels as an ovarian reserve marker in adolescent girls with autoimmune thyroiditis (AIT) and explore the relationship of this marker with autoimmunity and thyroid function biomarkers. Subjects and methods: This study included 96 adolescent girls with newly diagnosed AIT and 96 healthy, age- and sex-matched controls. All participants were evaluated with detailed history taking and physical examination, thyroid ultrasound, and measurement of levels of thyroid-stimulating hormone (TSH), free thyroxin (FT4), free triiodothyronine (FT3), antithyroid peroxidase antibodies (TPOAb), antithyroglobulin antibody (TGAb), estradiol, total testosterone, and anti-Müllerian hormone (AMH) levels. The LH/FSH ratio was also calculated. Among 96 patients evaluated, 78 were overtly hypothyroid and 18 were euthyroid. AMH levels were significantly lower in participants with overt hypothyroidism and euthyroidism compared with controls. Results: Serum levels of AMH correlated negatively with age, body mass index (BMI) standard deviation score (SDS), and TPOAb, TGAb, and TSH levels but positively with FT4 levels. In multivariate analysis, AMH levels correlated significantly with age (odds ratio [OR] = 1.65, 95% confidence interval [CI] 1.18-2.32, p = 0.05), BMI SDS (OR = 2.3, 95% CI, 2.23-3.50, p = 0.01), TSH (OR = 2.43, 95% CI 1.5-2.8, p = 0.01), and TPOAb (OR = 4.1, 95% CI 3.26-8.75, p = 0.001). Conclusions: Ovarian reserve of adolescent girls with AIT, as measured by serum AMH levels, is affected by thyroid autoimmunity and hypothyroidism, indicating a possible need for ovarian reserve monitoring in these patients.

A study to assess the quality of sleep among medical students of Mysuru, Karnataka, India

Background: Every individual requires a period of rest to enhance and empower his/her work ability. Adequate quality of sleep is a prerequisite for optimal functioning of the students� mind and body. Sleep problems are common in the general population. Medical students are one subgroup who are more vulnerable to poor sleep quality owing to multiple factors in their lifestyle. To assess the quality of sleep in a population of medical students of Mysore Medical College and Research Institute, Mysuru and to study the determinants affecting it. Methods: An institution-based cross-sectional study was conducted using convenience sampling among 132 medical students of Mysore Medical College and Research Institute. A pre-designed and pre-tested structured questionnaire developed using the Pittsburgh quality of sleep index (PQSI) Score and Epworth daytime sleepiness scale (EDSS) was used. The data collected was compiled in MS- Excel and analysed using statistical package of social sciences (SPSS)Version 20.0. Results: Out of 132 medical students who were enrolled in the study, 55.3% (73/132) had an abnormal PSQI score. Males had better quality of sleep compared to females. Abnormal PSQI scores were associated with stress, alcohol and smoking. Conclusions: Sleep quality plays a major role in maintaining a medical student抯 physical, mental and working capacity.

Prevalence of Hypertension Among Tribal Population in India: A Systematic Review and Meta-Analysis

Hypertension is an important worldwide public-health challenge and it is accountable for 7% of Disability Ad-justed Life Years (DALY) loss, and by the end of 2025 about 29% of world’s population is likely to suffer from hypertension. Tribal population constitute about 8% of the total population in India. Among tribal population, study on hypertension will provide an interesting outcome because studies across the world have shown a lower prevalence. The objective of the study was to estimate the pooled prevalence of hypertension among adult tribal populations in India and also to analyse the possible sources of heterogeneity in the estimate. A systematic search was performed in PubMed, Google scholar, Scopus, Embase MEDLINE, and journals for arti-cles published between 2001 and 2020. This is a systematic review and meta-analysis done on hypertension among tribal populations of India. Three authors independently reviewed the articles, performed quality as-sessment and data was extracted. Pooled estimate of hypertension was calculated. Subgroup analyses was performed. A total of 26 articles with a total number of subjects of 75,543 were included in the study. The pooled estimate of hypertension prevalence was 25.1% (95% CI: 24.7, 25.4). There was significant heteroge-neity among the studies (I2 = 98.2 and Q = 1289.37). It is essential to conduct larger cohort studies and ran-domised controlled trials to determine the causes of the increased prevalence of hypertension among the tribal population. The prevalence of hypertension among tribal population are essential as a source of prima-ry information and for rational planning of health services and will help public-health policy-makers to assign sufficient priority and resources for its management and prevention.

Fetal ductus venosus Doppler as a predictor of pregnancy outcome

Background: The ductus venosus (DV) transports oxygenated blood to the developing heart and brain by avoiding the hepatic circulation. Due to the anatomical location of the DV, measurement of DV blood flow velocity waveforms indirectly disclose the cardiac functions and health of the foetus, which represents the pressure gradient between the umbilical vein and right atrium. The aim of this study was to evaluate the value of ductus venosus pulstality index of veins in early pregnancy in prediction of adverse pregnancy outcomes.Methods: 50 pregnant women with a single viable foetus between 13 and 24 weeks participated in this prospective cross-sectional study from 2021 to 2022 at Tanta University Hospital.Results: PI in normal group ranged from 0.80-1.20 with mean value 0.90±0.130 and in abnormal group ranged from 0.46-0.50 with mean value 0.522±0.069. S/a ration in normal group ranged from 1.74-3.18 with mean value 2.30±0.40 and in abnormal group ranged from 1.50-2.05 with mean value 1.833±0.212. There was statistically significant difference between outcomes of pregnancy with ultrasound findings (p<0.05).Conclusions: Numerous foetal disorders that might result in cardiovascular deterioration and other aberrant outcomes in newborns can be managed clinically and predicted perinatally using the DV Doppler examination.

Effect of bilateral uterine artery ligation in cases of postpartum hemorrhage on ovarian reserve

Background: Bilateral uterine artery ligation (BUAL) is a fertility-preserving procedure used in women experiencing postpartum hemorrhage (PPH). However, the long-term effects of this procedure on ovarian reserve remain unclear. Aim to investigate the effect of BUAL in cases of PPH on ovarian reserve,Methods: This study was carried out at department of obstetrics and gynecology Tanta university on 40 patients divided into 2 groups: (The study group); included 20 patients underwent cesarean section with successful BUAL for intractable atonic PPH, (The control group); included 20 patients underwent cesarean section without BUAL; during a period between April 2020 and December 2021,Results: There is no-significant difference between study and control group according to AMH (ng/ml), resistivity index (RI) and pulsatility index (PI) of right and left uterine artery and ovarian artery after 6 months of bilateral UAL,Conclusions: Bilateral UAL had no negative effects on ovarian reserve or ovarian blood supply, so this treatment should be used as a fertility preservation technique to avoid hysterectomy in patients experiencing PPH.

Mechanical Thrombectomy for Acute Ischemic Stroke in Metastatic Cancer Patients: A Nationwide Cross-Sectional Analysis / 대한뇌졸중학회지

Background@#and Purpose Mechanical thrombectomy (MT) is the standard treatment for large vessel occlusion (LVO) acute ischemic stroke. Patients with active malignancy have an increased risk of stroke but were excluded from MT trials. @*Methods@#We searched the National Readmission Database for LVO patients treated with MT between 2016–2018 and compared the characteristics and outcomes of cancer-free patients to those with metastatic cancer (MC). Primary outcomes were all-cause in-hospital mortality and favorable outcome, defined as a routine discharge to home (regardless of whether home services were provided or not). Multivariate regression was used to adjust for confounders. @*Results@#Of 40,537 LVO patients treated with MT, 933 (2.3%) had MC diagnosis. Compared to cancer-free patients, MC patients were similar in age and stroke severity but had greater overall disease severity. Hospital complications that occurred more frequently in MC included pneumonia, sepsis, acute coronary syndrome, deep vein thrombosis, and pulmonary embolism (P<0.001). Patients with MC had similar rates of intracerebral hemorrhage (20% vs. 21%) but were less likely to receive tissue plasminogen activator (13% vs. 23%, P<0.001). In unadjusted analysis, MC patients as compared to cancer-free patients had a higher in-hospital mortality rate and were less likely to be discharged to home (36% vs. 42%, P=0.014). On multivariate regression adjusting for confounders, mortality was the only outcome that was significantly higher in the MC group than in the cancerfree group (P<0.001). @*Conclusion@#LVO patients with MC have higher mortality and more infectious and thrombotic complications than cancer-free patients. MT nonetheless can result in survival with good outcome in slightly over one-third of patients.