RÉSUMÉ
Objective@#To investigate the effect of preoperative neoadjuvant short-term high-dose preoperative radiotherapy (RT) (5 × 5 Gy) on early postoperative complications in patients with locally advanced rectal adenocarcinoma.@*Methods@#The study period was January 2017 to June 2018. The total number of patients with locally advanced rectal adenocarcinoma who were treated in Cancer Hospital of the University of Chinese Academy of Sciences Zhejiang Cancer Hospital was 120 patients. They were divided into study group and control group according to the random number table method, 60 patients in each group; the study group received neoadjuvant radiotherapy (25 Gy, 5 divisions) before surgery, one week after surgery; the control group was treated immediately after tumor diagnosis; the surgical related indicators and postoperative complications, life function of the two groups were compared.@*Results@#In the study group, complete pathological reactions were observed in 9 patients (15.0%) (no cancer cells were found in tumor specimens), and 12 patients (20.0%) found residual cancer under the microscope; intraoperative sphincter retention study group and control group was 100.0%(60/60), 83.3%(50/60)100%, there was significant difference (P=0.002). Patients in the study group were significantly more likely to have metastasis than the control group [11.7%(7/60) vs. 5.0%(3/60)] (P=0.017). All metastasis oral cases were closed within 3-6 months after operation. There was no significant difference in the incidence of postoperative complications between the two groups, and the odds of primary anastomotic leakage was also basically the same. Life function analysis showed that the study group patients were significantly better than the control group in terms of overall health status, role function and social function.@*Conclusions@#Preoperative short-term RT in locally advanced rectal cancer does not increase the risk of postoperative complications and increase the chance of surgical preservation of the sphincter.
RÉSUMÉ
Objective To investigate the effect of preoperative neoadjuvant short-term high-dose preoperative radiotherapy (RT) (5 × 5 Gy) on early postoperative complications in patients with locally advanced rectal adenocarcinoma.Methods The study period was January 2017 to June 2018.The total number of patients with locally advanced rectal adenocarcinoma who were treated in Cancer Hospital of the University of Chinese Academy of Sciences Zhejiang Cancer Hospital was 120 patients.They were divided into study group and control group according to the random number table method,60 patients in each group;the study group received neoadjuvant radiotherapy (25 Gy,5 divisions) before surgery,one week after surgery;the control group was treated immediately after tumor diagnosis;the surgical related indicators and postoperative complications,life function of the two groups were compared.Results In the study group,complete pathological reactions were observed in 9 patients (15.0%) (no cancer cells were found in tumor specimens),and 12 patients (20.0%) found residual cancer under the microscope;intraoperative sphincter retention study group and control group was 100.0%(60/60),83.3%(50/60)100%,there was significant difference (P =0.002).Patients in the study group were significantly more likely to have metastasis than the control group [11.7%(7/60) vs.5.0%(3/60)] (P=0.017).All metastasis oral cases were closed within 3-6 months after operation.There was no significant difference in the incidence of postoperative complications between the two groups,and the odds of primary anastomotic leakage was also basically the same.Life function analysis showed that the study group patients were significantly better than the control group in terms of overall health status,role function and social function.Conclusions Preoperative short-term RT in locally advanced rectal cancer does not increase the risk of postoperative complications and increase the chance of surgical preservation of the sphincter.
RÉSUMÉ
<p><b>OBJECTIVE</b>To evaluate the therapeutic effect of Chuzhen therapy on insomnia through clinical randomized controlled trials.</p><p><b>METHODS</b>Sixty cases of insomnia were randomly divided into a Chuzhen group (n=30) and an acupuncture group (n=30). Acupoints of Bazhen (Baihui Bazhen, Fengfu Bazhen, Shendao Bazhen) and Hechelu [from Dazhui (GV 14) to Mingmen (GV 4)] in the Chuzhen group, and Baihui (GV 20), Sishencong (EX-HN 1), etc. in the acupuncture group were selected, respectively. Four weeks treatments were carried out in the two groups, once daily for 5 times on week days. Three months after treatment, they were followed up and the therapeutic effects were assessed by the effective rate of sleep improvement and Pittsburgh Sleep Quality Index (PSQI).</p><p><b>RESULTS</b>After treatment, the sleep quality in the two groups was improved, but there were no differences in the effective rate of sleep improvement and PSQI between the two groups (all P > 0.05). Three months after treatment, the total effective rate of 85.2% in the Chuzhen group was better than 78.6% in the acupuncture group (P < 0.05). The total cumulative score of PSQI, sleep effectiveness and the factors of sleep obstacle in the Chuzhen group were significantly different from those in the acupuncture group (all P < 0.05).</p><p><b>CONCLUSION</b>Chuzhen therapy can increase long-term sleep quality and living quality through improving the effective rate of sleep and reducing the score of PSQI in the patients of insomnia.</p>