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Objective To compare the clinical efficacy of CT-guided high-voltage long-duration pulsed radiofrequency(PRF)with that of pudendal nerve block(NB)in the treatment of pudendal neuralgia(PN).Methods A total of 91 patients with confirmed PN were enrolled in this study.The patients were randomly divided into PRF group and NB group.The patients of the PRF group received CT-guided high-voltage long-duration PRF of the pudendal nerve,and the patients of the NB group received CT-guided pudendal nerve block.The visual analogue scale(VAS)score of pain,the time of keeping a sitting position,and the PHQ9-score were determined separately at one day,2 weeks,one month,3 months,and 6 months after treatment,and all procedure-related complications were recorded.Results A 6-month follow-up was accomplished in 87 patients,including 45 in the PRF group and 42 in the NB group.On the first day after operation,the VAS scores became significantly lower in both groups as compared with the preoperative VAS scores(P<0.01),and the VAS score in the NB group was strikingly lower than that in the PRF group(P=0.039).The postoperative one-month,3-month and 6-month VAS scores in the PRF group were remarkably lower than those in the NB group(P<0.05).The time of keeping a sitting position and PHQ9-scores at 3 months and 6 months after treatment in the PRF group were obviously better than those in the NB group(P<0.01).No procedure-related serious adverse reactions were observed in both groups.Conclusion CT-guided high-voltage long-duration PRF is superior to NB in more effectively relieving pain,prolonging the time of keeping a sitting position,and improving the depressed status of the patients with PN.(J Intervent Radiol,2023,32:1216-1220)
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Precision medicine promotes the development of individual medicine,but also brings about problems to patients' personal privacy,especially for the protection of genetic information.The priority is to establish relative legal framework and specific regulations.America has issued Precision Medicine Initiative:Privacy and Trust Principles and Data Security Policy Principles and Framework,which have become the pioneer in the establishment of related principles and systems.In order to promote the development of Chinese laws and regulations,it is essential to use American practice as reference according to the specific national conditions,and definitely build up several principles,such as informed consent,honesty and credibility,reasonable care and benefit balance,in order to provide perfect genetic data protection system for patients.
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OBJECTIVE:To investigate therapeutic efficacy and recurrence rate of vaginal administration of lactobacillus com-bined with chlorquinaldol-promestriene for senile patients with atrophic vaginitis. METHODS:150 senile patients with atrophic vag-initis were selected and divided into group A,B,C according to random number table,with 50 cases in each group. Group A was given Lactobacillus vaginal capsules,2 capsules,qd (at bedtime);group B given Chlorquinaldol-promestriene vaginal tablets,1 tablet,qd(at bedtime);group C given Chlorquinaldol-promestriene vaginal tablets,1 tablet,qd(at bedtime),and Lactobacillus vaginal capsules,2 capsules,qd,next morning,implanting into vagina. 3 groups received treatment for 18 d. Clinical efficacy, vaginal health score,vaginal symptom score and vaginal pH value were observed in 3 groups,and the occurrence of ADR and re-currence rate during follow-up period (12 months) were recorded. RESULTS:The total effective rate of group C was 94.00%, which was significantly higher than group A(72.00%)and B(74.00%),with statistical significance(P0.05). After treatment,vaginal health score of 3 groups were increased significantly,while vaginal symptom score and vaginal pH value were decreased significantly;and the improvement of above indexes in group C were significantly better than in group A and B,with statistical significance(P<0.05). No obvious ADR was found in 3 groups during treatment. The recurrence rate of group C during follow-up period(4.00%)was significantly lower than that of group A(18.00%)and group B(20.00%),with statistical significance(P<0.05). CONCLUSIONS:Vaginal administration of lactobacillus combined with chlorquinaldol-promestriene for se-nile patients with atrophic vaginitis can effectively relieve clinical symptoms and signs,improve vaginal cleanliness,regulate the lo-cal pH value and reduce the risk of recurrence,with good safety.
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<p><b>OBJECTIVE</b>The aim of this study was to compare the safety and efficacy profiles of R-CHOP and R-fCHOP regimes in the treatment of primary gastric diffuse large B cell lymphoma (PG-DLBCL).</p><p><b>METHODS</b>Data of PG-DLBCL patients admitted in our hospital from March 2010 to March 2014 were collected retrospectively. Differences in gastrointestinal bleeding and perforation between the R-CHOP group and R-fCHOP group were compared. The influence of the gastrointestinal complication on subsequent treatment was also analyzed. Treatment outcome of the two groups was also compared.</p><p><b>RESULTS</b>A total of 50 patients were included in this retrospective study. Forty of them were in the R-CHOP group, another ten were in the R-fCHOP group. Patients in the R-fCHOP group had a higher rate of Lugano late stage disease, and a relatively high rate of a deeper/larger ulcer. Fence occult blood test (FOBT) was positive in one (10.0%) patient in the R-fCHOP group, and 11 (31.4%) patients in the R-CHOP group, among them one had hematemesis and had to give up the subsequent chemotherapy. No perforation was observed in both groups. The response rate (RR) was 92.5% in the R-CHOP group and 90.0% in the R-fCHOP group (P > 0.05). The PFS was also comparable between the two groups (P > 0.05).</p><p><b>CONCLUSIONS</b>R-fCHOP regimen has a good safety profile in patients with Lugano late stage and deep/large ulcers, who are of high risk of gastrointestinal bleeding or perforation, and also has a comparable efficacy profile when compared with the R-CHOP regimen in short-term follow-up.</p>
Sujets)
Adulte , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Anticorps monoclonaux d'origine murine , Utilisations thérapeutiques , Protocoles de polychimiothérapie antinéoplasique , Utilisations thérapeutiques , Cyclophosphamide , Doxorubicine , Lymphome B diffus à grandes cellules , Traitement médicamenteux , Lymphome malin non hodgkinien , Prednisone , Études rétrospectives , Rituximab , Tumeurs de l'estomac , Résultat thérapeutique , VincristineRésumé
Objective To investigate the relationship between cardiovascular risk factors and arterial elasticity in elderly hypertensive patients.Methods 253 subjects were divided into two groups:hypertension group (n=141) and non-hypertension group (n =112).Carotid-femoral pulse wave velocity (C-FPWV),carotid-radial PWV (C-RPWV),height and weight were determined.Fasting plasma levels of blood glucose (BG),blood lipids,insulin,endothelins (ET),nitric oxide (NO) and high sensitivity C-reactive protein (hsCRP) were assessed.Results C-FPWV and CRPWV were higher in hypertension group than in non-hypertension group [(11.7±1.9) m/s vs.(9.7±1.1)m/s,(11.7±1.7) m/s vs.(9.4±1.1)m/s,t=8.43 and-6.30,both P<0.01].Body mass index (BMI),systolic blood pressure (SBP),diastolic blood pressure (DBP),levels of triglyceride (TG),BG,ET,NO and hsCRP,HOMA-IR had significant differences between the two groups (t=-5.27,-4.18,-6.00,6.29,-4.18,-4.86,-3.41,respectively,all P<0.05).Pearson correlation analysis showed that CFPWV was correlated with SBP,age,DBP,fasting BG,NO,ET,TG,HOMA IR,cholesterol (CHO),hsCRP (r=0.534,0.374,0.340,0.338,-0.306,0.242,0.228,0.225,-0.218,0.178,respectively,all P<0.05); C-RPWV was correlated with age,DBP,SBP,NO,TG (r=0.312,0.319,0.241,-0.197,0.151,respectively,all P<0.05).Multiple regression analysis demonstrated that C-FPWV=4.640 + 0.081× HOMA IR+ 0.047× age+0.035×SBP+0.29×TG-0.017×NO+0.014×ET+0.132×hsCRP,r2=0.514; CRPWV=3.161+0.034×age+0.033×DBP+0.313×fastingBG+0.013×ET-0.013×NO,r2=0.390.Conclusions The decreases of arterial elasticity are closely related with endothelial function,insulin resistance,levels of blood lipids and hsCRP in elderly patients with hypertension.
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Background and purpose:Although there is still no standard ifrst line chemotherapy regimen for metastatic gastric cancer (MGC), the doublet and triplet regimens containing platinum and lfuorouracil were most popular worldwidely. The ECF regimen is the classical and one of the most popular treatment choices in this setting, while the marrow suppression, the renal toxicity and poor compliance inhibits its usage. In order to improve its efifcacy and tolerability, this study conducted 2 phaseⅡ trials by modified ECF regimen, the EOF5 regimen (substituting cisplatin with oxaliplatin, shortening the continuous infusion period to 120 h), to treat patients with MGC since 2004. This paper reported the comprehensive results of the 2 studies.Methods:All the patients who enrolled in our previous2 phaseⅡ trials and received EOF5 as ifrst line treatment entered this study. Each patient received the treatment of epirubicin 50 mg/m2 iv d1, oxaliplatin 130 mg/m2 iv gtt d1 and 5-FU 375-425 mg/m2·d-1 civ 120 h, and repeated every 3 weeks. Efifcacy was analyzed every 6 weeks.Results:A total number of 178 patients (all were metastatic patients but 2 advanced patients with unresectable lesions) were included into this study. One hundred and seventy patients were evaluable, and 7 patients (3.9%) achieved complete response (CR), 76 patients (42.7%) achieved partial response (PR), 46.6% patients achieved overall response rate (ORR, CR+PR), and the cases of stable disease (SD) and progressive disease (PD) were 69 (38.8%) and 18 (10.1%), respectively. The median progress free survival (PFS) and overall survival (OS) were 6.0 months (95%CI: 5.2-6.8) and 12.6 months (95%CI: 8.9-16.3), 1-year and 2-year survival rate were 50.9% and 28.0%, respectively. Grade 3, 4 toxicity including: leucopenia (23.0), neutropenia (38.8%), anemia (6.5%), thrombocytopenia (23.5%), nausea/vomiting (14.1%), and peripheral neuropathy toxicity (1.2%). Among 75 patients who received second line treatment, the median survival from second line treatment was 8.0 months (95%CI: 4.8-11.2).Conclusion:EOF5 regimen is a highly effective regimen with moderate and manageable toxicity, and it providesa suitable alternative for the ifrst-line treatment of MGC.
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Purpose:To ascertain the curative effect and side effects from three different dividing dosage of DDP. Methods:315 cases of moderate and advanced tumors mainly treated with DDP and combined with chemotherapy were divided into 3 groups: (1)DDP 100 ml once(none divided group);(2) 30 to 40 ml of DDP per day, using continuously for 2 to 3 days(middle divided group); (3) 20 ml of DDP per day, using continuously for 5 days(small divided group). And 1 to 3 kinds of other chemotherapy medicines were used at same time. After using the above medicines, the curative effect, main reaction of nausea and vomiting and kidney toxicity were analysed. Results:The curative effect is better in group 1 and 2,but not so good in groups 3. The reaction of nausea and vomiting is slight in the group 2, and the kidney toxicity is high in group 1. Conclusions:The group 2 gets a good curative effect and only slight side effects, and is easy to apply. [