RÉSUMÉ
5-bromo-6-methoxy-5,6-dihydrouridine and its 2-thioanalogue were allowed to react with some substituted guanidine tautomers and alpha- mercapto-beta-phenylacrylic acid. The products are 5,6-cyclized derivatives of both of uridine and 2-thiouridine
Sujet(s)
4-Thiouridine/composition chimique , Guanidines/composition chimique , Thiols/composition chimique , Guanidines/analogues et dérivés , Thiols/analogues et dérivésRÉSUMÉ
Uridine and 4-thiouridine were converted into the corresponding 2,3-o-isopropylidene-5-thiocyanato derivatives. Then, each resulted derivative was reacted individually with both of ethyl alpha- chloroacetoacetate, ethyl alpha-bromobenzoylacetate and ethyl bromo pyruvate. Furthermore, these 5-thiocyanato products were transformed into the corresponding 5-mercapto analogues. The produced analogues were undergo ring formation to give the corresponding 4,5-cyclized pyrimidine derivatives
Sujet(s)
4-Thiouridine/composition chimique , Esters/composition chimique , Uridine/analogues et dérivés , 4-Thiouridine/analogues et dérivésRÉSUMÉ
Synthesis of some cytidine derivatives involving 4,5 cyclisation are performed by the individual reactions of both of 5-hydroxy, 5-mercapto and 5-amino cytidines with chloroethyl formate, thionyl chloride and thiophosgene successively. On the other hand, reactions of cytidine with chloroacetone or chloropropionaldehyde give 3,4-cyclized cytidine products