Résumé
Objective:To characterize the histopathological subtypes and their clinicopathological parameters of gender and onset age by common, rare and sparse primary esophageal malignant tumors (PEMT).Methods:A total of 272 437 patients with PEMT were enrolled in this study, and all of the patients were received radical surgery. The clinicopathological information of the patients was obtained from the database established by the State Key Laboratory of Esophageal Cancer Prevention & Treatment from September 1973 to December 2020, which included the clinical treatment, pathological diagnosis and follow-up information of esophagus and gastric cardia cancers. All patients were diagnosed and classified by the criteria of esophageal tumor histopathological diagnosis and classification (2019) of the World Health Organization (WHO). The esophageal tumors, which were not included in the WHO classification, were analyzed separately according to the postoperative pathological diagnosis. The χ 2 test was performed by the SPSS 25.0 software on count data, and the test standard α=0.05. Results:A total of 32 histopathological types were identified in the enrolled PEMT patients, of which 10 subtypes were not included in the WHO classification. According to the frequency, PEMT were divided into common (esophageal squamous cell carcinoma, ESCC, accounting for 97.1%), rare (esophageal adenocarcinoma, EAC, accounting for 2.3%) and sparse (mainly esophageal small cell carcinoma, malignant melanoma, etc., accounting for 0.6%). All the common, rare, and sparse types occurred predominantly in male patients, and the gender difference of rare type was most significant (EAC, male∶ female, 2.67∶1), followed with common type (ESCC, male∶ female, 1.78∶1) and sparse type (male∶ female, 1.71∶1). The common type (ESCC) mainly occurred in the middle thoracic segment (65.2%), while the rare type (EAC) mainly occurred in the lower thoracic segment (56.8%). Among the sparse type, malignant melanoma and malignant fibrous histiocytoma were both predominantly located in the lower thoracic segment (51.7%, 66.7%), and the others were mainly in the middle thoracic segment.Conclusion:ESCC is the most common type among the 32 histopathological types of PEMT, followed by EAC as the rare type, and esophageal small cell carcinoma and malignant melanoma as the major sparse type, and all of which are mainly occur in male patients. The common type of ESCC mainly occur in the middle thoracic segment, while the rare type of EAC mainly in the lower thoracic segment. The mainly sparse type of malignant melanoma and malignant fibrous histiocytoma predominately occur in the lower thoracic segment, and the remaining sparse types mainly occur in the middle thoracic segment.
Résumé
Objective MMP-9 and CD44 together position in the cell surface,and this kind of together positions to help the CD44 vto settle anchor roans MMP-9s to also decline a solution to the gum original IV at the cell surface and promote tumor cell gradually. Stopping the empress of the function of CD44 with the dissolubility CD44 can immediately make it lose the function that the anchor man series MMP-9. But is settle by the CD44 anchor manses superficial at the cell of the MMP-9 can also make TGF-β1 of have no activity-TGF-β1 ex- bodies activate and activate of TGF-β1 new-born blood vessel growth is the essential growth factor. This text passes the MMP-9 and TGF-β1 which settles to the CD44 anchor manses-TGF-β1 the expression circumstance carries on analysis in the brain star polygon ceil lump,as to it's express meaning to carry on a research,to the CD44,MMP-9,TGF-β1 gradually transfer amedium function to carry on a first step study in the brain star polygon cell lump,in the meantime to the CD44,MMP-9,TGF-β1 relativities carry on an analytical research. Methods Totally collect 2006 subsidiary hospital of Zheng4 Zhou's university first and Xu3 Chang hospital surgical operation in the city center excision of the brain star polygon coil lump the specimen be 98 and apply an immunity set to turn the SP method examination tumor the CD44,MMP-9,TGF-β1 in the organization-TGF-β1 expression,analytical CD44, MMP-9,TGF-β1 with and CD44, MMP-9,TGF-β1 of the brain star polygon cell lump ratings-TGF- 131. The relation of one its. Results (1)CD44 the expression rote is 77.55%(76/98) in the star polygon cell lump organization and show Zhao Gao to organize 0 at the normal brain (P<0.05). Pass the related examination of the Spearman grade,different Class CD44 expression r=0.95,P=0.046, have covariance to learn meaning,the of the star polygon ceil lump Class and the CD44 male degree-present just related. Use the Fishers precision examination method to carry on an examination to the different Claas,P=0.00027,the composing ratio which explains an of different Class CD44 expressions contains difference. (2)MMP-9 the expression rate is 69.38%(68/98) in the star polygon cell lump organization and show Zhan Gan to organize at the normal brain (P< 0.05). Pass the related examination of the Spearman grade, different Class MMP-9 expression r=0.89,P=0.038,have eovariance to learn meaning.The of the star polygon ceil lump Class and the MMP-9 male degree present just related,the composing circumstance which uses the Fishers precision examination method 4 observation result of the Class MMP-9s to the tumor carries on an examination,P=1.12×10-7. (3)TGF-β1 the expression rate is 74.481%(73/98) in the star polygon ceil lump organization and show Zhao Gao to organize at the normal brain (P<0.05). Pass the related examination of the Spearman grade,different Class TGF-β1 expression r=0.91,P=0.046,have covariance to learn intoning. The star polygon cell lump Class and TGF-β1 of male degrees present just related.Use the Fishers precision examination method 4 Class TGF-β1 to the tumor-TGF-β1 composing circumstance of observation result carry on an examination,P=0.0001. (4)Star polygon cell CD44,MMP-9,TGF in lump-TGF-β1 expression of relativity analysis CD44 expression masculine gender of in the case,the male expression rate of MMP-9 is 94.12%,CD44 expression feminine gender of in the case,the feminine gender expression of the MMP-9 rate is 60.00%, of the expression and the expressions MMP-9s of CD44 presents a just related relation (the row contact few rp=0. 496016, P=1.559 × 10-8). The CD44 expresses a male case In,TGF-β1 male expression rates is 82.89%,in the ease of the CD44 expression feminine gender,TGF-β1 feminine gender expression rates is 54.55%, the expression and TGF-β1 of CD44-TGF-β1 expressions present a just related relation (the row contact few rp=0.3136, P = 0.001076). The MMP-9 expresses a male case in, TGF-β1 male expression rates is 91.17%,in the ease of the MMP-9 expression feminine gender,TGF-β1 feminine gender expression rates is 63.33%,Be learned analysis the enunciation MMP-9 to express by covariance and TGF-β1 expressions present a just related relation (the row contact few rp=0.4825,P=4.93 × 10-8). Conclusion The deteedion of MMP-9,CD44 and TGF-β1 is significance for prognosis of the brain star polygon cell lump.