Résumé
No abstract available.
Sujets)
Adulte , Humains , Mâle , Autoantigènes/génétique , Protéines du cycle cellulaire/génétique , Chromosomes humains de la paire 8 , Chromosomes humains de la paire 9 , Kinase Janus-2/génétique , Syndromes myéloprolifératifs/complications , Sarcome myéloïde/complications , Translocation génétiqueRésumé
Recent advances in chemotherapy have led to increased survival rates for patients with hematologic malignancies. However, standard chemotherapies, including alkylating agents for non-Hodgkin lymphoma, could induce therapy-related myeloid neoplasms (t-MNs), a group of disorders categorized by the World Health Organization in 2008. Here, we report a case of coexistence of bone marrow (BM)-involved refractory marginal zone B-cell lymphoma (MZL) and therapy-related myelodysplastic syndrome (t-MDS). Simultaneous presence of refractory lymphoma and t-MN in the BM is rare, and this is the first report in Korea. The patient received allogeneic hematopoietic stem cell transplantation (HSCT) to cure both the MZL and t-MDS. Since the HSCT, he has been stable for 21 months without any evidence of recurrence.