Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Acta Pharmaceutica Sinica ; (12): 395-399, 2011.
Article Dans Chinois | WPRIM | ID: wpr-348942

Résumé

This study is to investigate the protective effects of the SB203580 against radiation induced mortality and intestinal injury of mice. A total of 67 male C57BL/6 mice (20.0-22.0 g) were matched according to body weight and randomly assigned to one of three groups: control, total body irradiation exposure (IR, 7.2 Gy) only, and IR (7.2 Gy) + SB203580 (15 mg x kg(-1)). 30 days survival rate was observed in the experiment. In intestinal injury experiment, the expression levels of caspase-3, Ki67, p53 and p-p38 were assayed in the mice intestine crypts. The results showed that the 30 days survival rate was 100% (control), 0 (IR) and 40% (IR+ SB203580), separately. Compared to the IR groups, the positive cells of caspase-3, p53 and p-p38 in crypt cells decreased 33.00%, 21.78% and 34.63%, respectively. The rate of positive cells of Ki67 increased 37.96%. Significant difference was found between all of them (P < 0.01). SB203580 potently protected against radiation-induced lethal and intestinal injury in mice, and it may be a potential radio protector.


Sujets)
Animaux , Mâle , Souris , Apoptose , Effets des rayonnements , Caspase-3 , Métabolisme , Antienzymes , Pharmacologie , Imidazoles , Pharmacologie , Intestins , Métabolisme , Anatomopathologie , Antigène KI-67 , Métabolisme , Souris de lignée C57BL , Pyridines , Pharmacologie , Lésions radiques expérimentales , Métabolisme , Mortalité , Anatomopathologie , Radioprotecteurs , Pharmacologie , Répartition aléatoire , Protéine p53 suppresseur de tumeur , Métabolisme , Irradiation corporelle totale , p38 Mitogen-Activated Protein Kinases , Métabolisme
SÉLECTION CITATIONS
Détails de la recherche